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https://www.readbyqxmd.com/read/28099077/disease-complexity-in-a-declining-alaskan-muskox-ovibos-moschatus-population
#1
Josephine A Afema, Kimberlee B Beckmen, Stephen M Arthur, Kathy Burek Huntington, Jonna A K Mazet
The muskox ( Ovibos moschatus ) population inhabiting the eastern North Slope (ENS) of Alaska declined dramatically during 1999-2006, whereas populations in western Alaska (WA) were stable or increasing. To understand morbidity and mortality factors contributing to the decline, Alaska Department of Fish and Game conducted pathologic investigations of carcasses from 2005 until 2008. Additionally, archived sera from both ENS and WA muskoxen collected during 1984-1992, before the documented beginning of the ENS decline; sera collected during 2000, near the beginning of the decline; and contemporary sera (from live capture-release, adult females) collected during 2006, 2007, and 2008 were analyzed to determine whether prevalence of antibody to potential pathogens differed in the two areas or changed over time...
January 18, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28055330/hepatic-lipodystrophy-in-galloway-calves
#2
M Wieland, S Mann, A Hafner-Marx, A Ignatius, M Metzner
Hepatic lipodystrophy in Galloway calves is a fatal liver disease affecting a small proportion of the Galloway breed described in different parts of Europe and North America during the past decades. The clinical findings include a diversity of neurological signs. Clinical pathology findings frequently indicate hepatobiliary disease. Postmortem examination reveals an enlarged, pale yellow, and firm liver. Histologic lesions include hepatic fibrosis, hepatic lipidosis, and bile duct hyperplasia. To date, the etiopathogenesis remains obscure...
January 1, 2017: Veterinary Pathology
https://www.readbyqxmd.com/read/28031458/normalization-of-hepatic-homeostasis-in-the-npc1nmf164-mouse-model-of-niemann-pick-type-c-disease-treated-with-the-histone-deacetylase-inhibitor-vorinostat
#3
Andrew B Munkacsi, Natalie Hammond, Remy T Schneider, Dinindu S Senanayake, Katsumi Higaki, Kirill Lagutin, Stephen J Bloor, Daniel S Ory, Robert A Maue, Fannie W Chen, Antonio Hernandez-Ono, Nicole Dahlson, Joyce J Repa, Henry N Ginsberg, Yiannis A Ioannou, Stephen L Sturley
Niemann-Pick type C (NP-C) disease is a fatal genetic lipidosis for which there is no FDA-approved therapy. Vorinostat, an FDA-approved inhibitor of histone deacetylases, ameliorates lysosomal lipid accumulation in cultured NP-C patient fibroblasts. To assess the therapeutic potential of histone deacetylase inhibition, we pursued these in vitro observations in two murine models of NP-C disease. Npc1nmf164 mice, which express a missense mutation in the NPC1 gene, were treated intraperitoneally, from weaning, with the maximum tolerated dose of Vorinostat (150 mg/kg, 5 days per week)...
December 28, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28018795/nephrotoxicity-of-methadone-a-systematic-review
#4
REVIEW
Samira Alinejad, Kazem Ghaemi, Mohammad Abdollahi, Omid Mehrpour
BACKGROUND: Methadone is commonly administered for chronic pain relief and treatment of opioid dependence. Concurrent with its increased consumption, toxicities and fatalities have increased. One of the adverse effects of opioid analgesics, including methadone, is that of nephrotoxicity. Opioids can have an effect on renal function through several different mechanisms. METHODS: We searched common bibliographical databases for the terms methadone, toxicity, poisoning, kidney, renal, and nephrotoxicity and summarize our findings in this review...
2016: SpringerPlus
https://www.readbyqxmd.com/read/28005494/glomerular-lesions-in-proteinuric-miniature-schnauzer-dogs
#5
E Furrow, G E Lees, C A Brown, R E Cianciolo
Miniature Schnauzer dogs are predisposed to idiopathic hypertriglyerceridemia, which increases risk for diseases such as pancreatitis and gallbladder mucocele. Recently, elevated triglyceride concentrations have been associated with proteinuria in this breed, although it is difficult to determine which abnormality is primary. Retrospective review of renal tissue from 27 proteinuric Miniature Schnauzers revealed that 20 dogs had ultrastructural evidence of osmophilic globules consistent with lipid in glomerular tufts...
January 1, 2016: Veterinary Pathology
https://www.readbyqxmd.com/read/27960019/-glomerular-lipidosis
#6
Sandro Feriozzi
Lipidoses occur for an abnormal storage parenchymal deposition of lipids and products of their metabolism in large amounts or sometimes, involving only some particular tissue structures. The lipid storage is usually due to an inborn error causing an enzyme absence /deficiency in the primary lipidoses and to a complex metabolism alterations in the secondary forms. However, histologically all lipid depositions look very similar, and immunohistochemical investigation, clinical pictures knowledge and genetic tests need to make a correct diagnosis...
2016: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/27793708/cholesteryl-hemiesters-alter-lysosome-structure-and-function-and-induce-proinflammatory-cytokine-production-in-macrophages
#7
Neuza Domingues, Luís M B B Estronca, João Silva, Marisa R Encarnação, Rita Mateus, Diogo Silva, Inês B Santarino, Margarida Saraiva, Maria I L Soares, Teresa M V D Pinho E Melo, António Jacinto, Winchil L C Vaz, Otília V Vieira
RATIONALE: Cholesteryl hemiesters are oxidation products of polyunsaturated fatty acid esters of cholesterol. Their oxo-ester precursors have been identified as important components of the "core aldehydes" of human atheromata and in oxidized lipoproteins (Ox-LDL). We had previously shown, for the first time, that a single compound of this family, cholesteryl hemisuccinate (ChS), is sufficient to cause irreversible lysosomal lipid accumulation (lipidosis), and is toxic to macrophages. These features, coupled to others such as inflammation, are typically seen in atherosclerosis...
February 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27760890/pathology-and-molecular-characterization-of-recent-leucocytozoon-caulleryi-cases-in-layer-flocks
#8
Hae Rim Lee, Bon-Sang Koo, Eun-Ok Jeon, Moo-Sung Han, Kyung-Cheol Min, Seung Baek Lee, Yeonji Bae, In-Pil Mo
Leucocytozoonosis was found in three layer farms in chickens with suspected fatty liver or fatty liver hemorrhagic syndrome in Korea between 2009 and 2011. These layer chicken flocks showed both mortality and decreased egg production for one or two weeks when they were between 59 and 82 weeks old. At the necropsy, the most prominent gross lesions were found in the liver, which was enlarged, had a fragile texture, exhibited yellowish discolorations, and had various hemorrhagic lesions. Tissue reactions associated with megaloschizonts specific for Leucocytozoon caulleryi were prominent upon microscopic examination of the liver without significant lipidosis...
2016: Journal of Biomedical Research
https://www.readbyqxmd.com/read/27672403/dietary-broccoli-protects-against-fatty-liver-development-but-not-against-progression-of-liver-cancer-in-mice-pretreated-with-diethylnitrosamine
#9
Yung-Ju Chen, Angela D Myracle, Matthew A Wallig, Elizabeth H Jeffery
Western-style high fat, high sugar diets are associated with non-alcoholic fatty liver disease (NAFLD) and increased liver cancer risk. Sulforaphane from broccoli may protect against these. Previously we initiated broccoli feeding to mice prior to exposure to the hepatocarcinogen diethylnitrosamine (DEN), and saw protection against NAFLD and liver cancer. Here we administered DEN to unweaned mice, initiating broccoli feeding two weeks later, to determine if broccoli protects against cancer progression. Specifically, male 15-day-old C57BL/6J mice were given DEN and placed on a Western or Western+10%Broccoli diet from the age of 4 weeks through 7 months...
June 2016: Journal of Functional Foods
https://www.readbyqxmd.com/read/27663373/texture-analysis-of-b-mode-ultrasound-images-to-stage-hepatic-lipidosis-in-the-dairy-cow-a-methodological-study
#10
Tommaso Banzato, Enrico Fiore, Massimo Morgante, Elisabetta Manuali, Alessandro Zotti
Hepatic lipidosis is the most diffused hepatic disease in the lactating cow. A new methodology to estimate the degree of fatty infiltration of the liver in lactating cows by means of texture analysis of B-mode ultrasound images is proposed. B-mode ultrasonography of the liver was performed in 48 Holstein Friesian cows using standardized ultrasound parameters. Liver biopsies to determine the triacylglycerol content of the liver (TAGqa) were obtained from each animal. A large number of texture parameters were calculated on the ultrasound images by means of a free software...
October 2016: Research in Veterinary Science
https://www.readbyqxmd.com/read/27591279/detection-of-differentially-expressed-genes-in-broiler-pectoralis-major-muscle-affected-by-white-striping-wooden-breast-myopathies
#11
Paolo Zambonelli, Martina Zappaterra, Francesca Soglia, Massimiliano Petracci, Federico Sirri, Claudio Cavani, Roberta Davoli
White Striping and Wooden Breast (WS/WB) are abnormalities increasingly occurring in the fillets of high breast yield and growth rate chicken hybrids. These defects lead to consistent economic losses for poultry meat industry, as affected broiler fillets present an impaired visual appearance that negatively affects consumers' acceptability. Previous studies have highlighted in affected fillets a severely damaged muscle, showing profound inflammation, fibrosis, and lipidosis. The present study investigated the differentially expressed genes and pathways linked to the compositional changes observed in WS/WB breast muscles, in order to outline a more complete framework of the gene networks related to the occurrence of this complex pathological picture...
December 1, 2016: Poultry Science
https://www.readbyqxmd.com/read/27468031/radiographic-and-ultrasonographic-abdominal-anatomy-in-captive-ring-tailed-lemurs-lemur-catta
#12
Modesta Makungu, Wencke M du Plessis, Michelle Barrows, Hermanus B Groenewald, Katja N Koeppel
The ring-tailed lemur (Lemur catta) is primarily distributed in south and southwestern Madagascar. It is classified as an endangered species by the International Union for Conservation of Nature. Various abdominal diseases, such as hepatic lipidosis, intestinal ulcers, cystitis, urinary tract obstruction, and neoplasia (e.g., colonic adenocarcinoma and cholangiocarcinoma), have been reported in this species. The aim of this study was to describe the normal radiographic and ultrasonographic abdominal anatomy in captive ring-tailed lemurs to provide guidance for clinical use...
June 2016: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/27450434/white-striping-and-woody-breast-myopathies-in-the-modern-poultry-industry-a-review
#13
V A Kuttappan, B M Hargis, C M Owens
Myopathies are gaining the attention of poultry meat producers globally. White Striping (WS) is a condition characterized by the occurrence of white striations parallel to muscle fibers on breast, thigh, and tender muscles of broilers, while Woody Breast (WB) imparts tougher consistency to raw breast fillets. Histologically, both conditions have been characterized with myodegeneration and necrosis, fibrosis, lipidosis, and regenerative changes. The occurrence of these modern myopathies has been associated with increased growth rate in birds...
November 1, 2016: Poultry Science
https://www.readbyqxmd.com/read/27413566/symmetric-lipomatosis-arising-in-the-tongue-presenting-as-macroglossia-and-articulatory-disorder
#14
Masanori Kudoh, Ken Omura, Arata Satsukawa, Koshi Matsumoto, Takahide Taguchi, Hiroyuki Harada, Yoshimasa Ishii
Symmetric lipomatosis is definitively characterized by symmetric, tumorous lipomatous proliferation of adipose tissue that often develops in the head and neck, shoulders, and upper trunk. However, in the oral region, symmetric lipomatosis of the tongue (SLT) is an extremely rare condition related to generalized lipidosis that is often caused by chronic alcoholism. It is characterized by multiple symmetric lipomatous nodules and diffuse bilateral swelling located within the tongue. We report an extremely rare case of SLT arising in an 80-year-old man with a long history of alcoholic liver cirrhosis...
2016: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/27412480/phthalate-metabolites-in-the-european-eel-anguilla-anguilla-from-mediterranean-coastal-lagoons
#15
C Fourgous, M Chevreuil, F Alliot, E Amilhat, E Faliex, S Paris-Palacios, M J Teil, A Goutte
The levels and fate of phthalate metabolites have been poorly evaluated in fish, despite their potential ecotoxicological impacts. The present study aims to characterize the levels of phthalate metabolites in muscle tissue of yellow eels (Anguilla anguilla) from two coastal Mediterranean lagoons, during three sampling periods. Nine phthalate metabolites were detected in >70% of the samples. Slightly higher levels of phthalate metabolites were detected in March and June compared to October, suggesting possible seasonal variations in environmental release and/or phthalate metabolization process by eels...
November 1, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27373561/in-vitro-monitoring-of-time-and-dose-dependent-cytotoxicity-of-aminated-nanoparticles-using-raman-spectroscopy
#16
Esen Efeoglu, Alan Casey, Hugh J Byrne
Investigation of possible adverse health effects of nanomaterials, in a rapid multi-parametric fashion, has become increasingly important, due to their increased production and potential uses in a wide range of application areas, from cosmetics to pharmaceutics. Although conventional in vitro cytotoxicological techniques provide valuable information about the particle toxicity, the importance of gaining high content information in a single assay with the analysis of multiple parameters in a non-invasive and label-free way is still one of the biggest challenges in nanotoxicology...
September 21, 2016: Analyst
https://www.readbyqxmd.com/read/27297495/metabolic-effects-of-obesity-and-its-interaction-with-endocrine-diseases
#17
REVIEW
Melissa Clark, Margarethe Hoenig
Obesity in pet dogs and cats is a significant problem in developed countries, and seems to be increasing in prevalence. Excess body fat has adverse metabolic consequences, including insulin resistance, altered adipokine secretion, changes in metabolic rate, abnormal lipid metabolism, and fat accumulation in visceral organs. Obese cats are predisposed to endocrine and metabolic disorders such as diabetes and hepatic lipidosis. A connection likely also exists between obesity and diabetes mellitus in dogs. No system has been developed to identify obese pets at greatest risk for development of obesity-associated metabolic diseases, and further study in this area is needed...
September 2016: Veterinary Clinics of North America. Small Animal Practice
https://www.readbyqxmd.com/read/27147282/retrospective-evaluation-of-acute-liver-failure-in-dogs-1995-2012-49-cases
#18
Carrie Lester, Johanna Cooper, Rachel M Peters, Cynthia R L Webster
OBJECTIVE: To characterize the clinical presentation and outcome of dogs with acute liver failure (ALF). DESIGN: Retrospective case series from January 1995 to December 2012. SETTING: University teaching hospital. ANIMALS: Forty-nine dogs were diagnosed with ALF defined as the acute onset of clinical signs accompanied by serum hyperbilirubinemia and coagulopathy (prothrombin time >1.5 times the upper limit of the reference interval) with or without signs of hepatic encephalopathy...
July 2016: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/27111715/lipoid-liver-disease-atherosclerosis-and-glomerular-lipidosis-in-a-gulf-flounder-paralichthys-albigutta-jordan-gilbert-1882-a-case-report
#19
J Dill, C Brown, K Heym, A Camus
No abstract text is available yet for this article.
April 25, 2016: Journal of Fish Diseases
https://www.readbyqxmd.com/read/27038534/multiple-acyl-coa-dehydrogenase-deficiency-madd-as-a-cause-of-late-onset-treatable-metabolic-disease
#20
A Béhin, C Acquaviva-Bourdain, S Souvannanorath, N Streichenberger, S Attarian, G Bassez, M Brivet, A Fouilhoux, A Labarre-Villa, A Laquerrière, L Pérard, P Kaminsky, J Pouget, O Rigal, C Vanhulle, B Eymard, C Vianey-Saban, P Laforêt
INTRODUCTION: Late-onset multiple acyl-CoA dehydrogenase deficiency (MADD) is a rare, treatable, beta-oxidation disorder responsible for neuromuscular symptoms in adults. This case series describes the clinical and biochemical features of 13 French patients with late-onset MADD. METHODS AND RESULTS: Thirteen ambulant patients (eight women, five men), with a median age at onset of 27 years, initially experienced exercise intolerance (n=9), isolated muscle weakness (n=1) and a multisystemic pattern with either central nervous system or hepatic dysfunction (n=3)...
March 2016: Revue Neurologique
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