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https://www.readbyqxmd.com/read/29475210/-comparison-of-international-guidelines-for-the-application-of-cardiotocography
#1
Phillip Schulten Sebastian, Jan Philip Suppelna, Timoleon Dagres, Günter Noè, Michael Anapolski, Joscha Reinhard, Harald Krentel, Clemens Tempfer, Sven Schiermeier
OBJECTIVE: This study examines the recommendations of international guidelines on the use of antepartum and intrapartum cardiotocography. MATERIAL AND METHODS: The guidelines of Germany, Canada, UK, USA, Sri Lanka, Australia as well as FIGO have been compared. The recommendations on the use of cardiotocography were separately evaluated for antepartum and intrapartum use. RESULTS: Antepartum: In risk-free pregnancies the use of cardiotocography is not recommended in all countries...
February 23, 2018: Zeitschrift Für Geburtshilfe und Neonatologie
https://www.readbyqxmd.com/read/29475209/perceptually-regulated-exercise-test-allows-determination-of-v%C3%AB-o2max-and-ventilatory-threshold-but-not-respiratory-compensation-point-in-trained-runners
#2
Perrine Truong, Gregoire P Millet, Boris Gojanovic
This study aimed to investigate the differences in maximal oxygen uptake (V̇O2max ) and submaximal thresholds between a standard graded exercise test (GXT) and a perceptually regulated graded exercise test (PRGXT) in trained runners. Eleven well-trained middle- to long-distance runners performed both tests in a randomized order. PRGXT used incremental "clamps" of rating of perceived exertion (RPE) over 10×1-min stages on an automated treadmill equipped with a sonar sensor allowing them to change their running speed instantly and in a natural way...
February 23, 2018: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29475206/association-between-forefoot-bone-length-and-performance-in-male-endurance-runners
#3
Hiromasa Ueno, Tadashi Suga, Kenji Takao, Takahiro Tanaka, Jun Misaki, Yuto Miyake, Akinori Nagano, Tadao Isaka
Recently, we reported that the forefoot bones were longer in sprinters than in non-sprinters, and that longer forefoot bones correlated with higher sprint performance in sprinters. To further understand the superiority of long forefoot bones in athletic performance, we examined whether forefoot bone length was associated with running performance in endurance runners. The length of the forefoot bones of the big and second toes were measured using magnetic resonance imaging in 45 male well-trained endurance runners and 45 male untrained subjects...
February 23, 2018: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29475203/venous-thromboembolism-and-route-of-delivery-review-of-the-literature
#4
Matheus Schimidt Evangelista, Karina Slompo, Jorge Rufino Ribas Timi
Venous thromboembolism events are important causes of maternal death during pregnancy and the postpartum period worldwide. A review of the literature with the objective of evaluating venous thromboembolism events in the puerperium according to the route of delivery was performed through a bibliographic survey in the Medline, LILACS and Scielo databases. We observed that patients submitted to cesarean sections present a significantly higher risk of developing venous thromboembolism when compared with those who undergo spontaneous vaginal delivery...
February 23, 2018: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/29475191/factor-structure-and-psychometric-properties-of-a-romanian-translation-of-the-drive-for-muscularity-scale-dms-in-university-men
#5
Viren Swami, Mona Vintila, Otilia Tudorel, Cosmin Goian, David Barron
We examined the psychometric properties of a Romanian translation of the 15-item Drive for Muscularity Scale (DMS). Male university students from Romania (N = 343) completed the DMS, as well as measures of self-esteem, body appreciation, and muscle discrepancy. Exploratory factor analysis indicated that DMS scores reduced to two factors that related to muscularity-oriented attitudes and behaviours, with both first-order factors loading onto a higher-order factor. However, confirmatory factor analysis indicated that a model with two first-order factors and a higher-order factor had poor fit...
February 20, 2018: Body Image
https://www.readbyqxmd.com/read/29475183/the-role-of-dimethyl-sulfoxide-dmso-in-ex-vivo-examination-of-human-skin-burn-injury-treatment
#6
Anna Pielesz, Andrzej Gawłowski, Dorota Biniaś, Rafał Bobiński, Marek Kawecki, Agnieszka Klama-Baryła, Diana Kitala, Wojciech Łabuś, Justyna Glik, Jadwiga Paluch
Dimethyl sulfoxide (DMSO) is one of the most versatile solvents in biological science, therefore it is frequently used as a solvent in biological studies and as a vehicle for drug therapy. DMSO readily penetrates, diffuses through biological membranes and ipso facto increases fluidity of liposomal membranes modelling stratum corneum. Thermal injury is associated with the appearance of lipid peroxidation products in the burned skin. The influence of DMSO on protein structure and stability is concentration and temperature dependant...
February 13, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29475179/comprehensive-characteristics-of-the-anticoagulant-activity-of-dabigatran-in-relation-to-its-plasma-concentration
#7
Willemijn J Comuth, Linda Ø Henriksen, Daan van de Kerkhof, Steen E Husted, Steen D Kristensen, Moniek P M de Maat, Anna-Marie B Münster
BACKGROUND: Issues with laboratory measurement of dabigatran include: 1. Do coagulation assays reflect dabigatran plasma concentrations? 2. Do samples from patients treated with dabigatran have the same coagulability as dabigatran-spiked samples from healthy volunteers? 3. What is the long-term stability of dabigatran after storage at -80 °C? This study aims to evaluate these questions. MATERIALS AND METHODS: Ecarin chromogenic assay (ECA), a laboratory-developed diluted thrombin time (LD-dTT), prothrombin time (PT) and activated partial thromboplastin time (APTT) and ROTEM® were used to measure dabigatran anticoagulant activity and liquid chromatography-tandem mass spectrometry (LC-MS/MS) to measure dabigatran plasma concentrations...
February 17, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29475172/brain-network-alteration-in-patients-with-temporal-lobe-epilepsy-with-cognitive-impairment
#8
Hongyu Yang, Chao Zhang, Chang Liu, Tao Yu, Guojun Zhang, Nan Chen, Kuncheng Li
The aims of this study were to investigate the brain network alternation in patients with temporal lobe epilepsy (TLE) with and without cognitive impairment (CI) using functional magnetic resonance imaging (fMRI) and to further explore the potential mechanisms of epilepsy-induced CI. Forty patients with TLE and nineteen healthy controls (HCs) were recruited for this study. All participants received the Montreal Cognitive Assessment (MoCA) test, and the patients were divided into CI (n=21) and cognitive nonimpairment (CNI) groups (n=19) according to MoCA performance...
February 20, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29475162/the-evaluation-of-arsenic-contamination-potential-speciation-and-hydrogeochemical-behaviour-in-aquifers-of-punjab-pakistan
#9
Muhammad Bilal Shakoor, Irshad Bibi, Nabeel Khan Niazi, Muhammad Shahid, Muhammad Farrakh Nawaz, Abida Farooqi, Ravi Naidu, Mohammad Mahmudur Rahman, Ghulam Murtaza, Andreas Lüttge
In this study, we tested 123 groundwater wells from five different areas of Punjab, Pakistan for arsenic (As) contamination level and species, as well as delineated hydrogeochemical behaviour of As in aquifers. Results revealed that 75% and 41% of the groundwater wells exceeded the safe As limit of World Health Organisation (WHO, 10 μg L-1 ) and Pakistan-EPA (50 μg L-1 ), respectively. Arsenite (As(III)) and arsenate (As(V)) spanned 0-80% and 20-100% of total As (1.2-206 μg L-1 ), respectively...
February 3, 2018: Chemosphere
https://www.readbyqxmd.com/read/29475156/potent-hydrazone-derivatives-targeting-esophageal-cancer-cells
#10
Ling-Yu Li, Jia-Di Peng, Wenjuan Zhou, Hui Qiao, Xin Deng, Zhou-Hua Li, Ji-Deng Li, Yun-Dong Fu, Song Li, Kai Sun, Hong-Min Liu, Wen Zhao
Hydrazone and their derivatives are a series of highly active molecules, which are widely used as lead compounds for the research and development of new anti-cancer drugs. In this study, 20 compounds were synthesized, based on this scaffold and their in vitro cytotoxicity against 6 cancer cell lines, including EC9706, SMMC-7721, MCF7, PC3, MGC-803 and EC109 was tested. Among them, compound 6p, showed strong anti-proliferative activities on esophageal carcinoma cells: EC9706 and EC109 with IC50 values of 1...
February 14, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29475147/halophilic-starch-degrading-bacteria-isolated-from-sambhar-lake-india-as-potential-anode-catalyst-in-microbial-fuel-cell-a-promising-process-for-saline-water-treatment
#11
Ankisha Vijay, Shivam Arora, Sandeep Gupta, Meenu Chhabra
In this study, Microbial Fuel Cell (MFC) capable of treating saline starch water was developed. Sodium chloride (NaCl) concentrations ranging from 500 mM to 3000 mM were tested at the anode. Nitrate was used as an electron acceptor at the biocathode. The halophilic bacteria were isolated from Sambhar Lake, India. Results indicated successful removal of starch (1.83 kg/m3 -d) and nitrate (0.13 kg/m3 -d NO3 - -N) with concomitant power output of 207.05 mW/m2 at 1000 mM NaCl concentration. An increase in power density from 71...
February 10, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29475146/the-fate-of-trace-organic-contaminants-during-anaerobic-digestion-of-primary-sludge-a-pilot-scale-study
#12
Hop V Phan, Richard Wickham, Sihuang Xie, James A McDonald, Stuart J Khan, Hao H Ngo, Wenshan Guo, Long D Nghiem
A pilot-scale study was conducted to investigate the fate of trace organic contaminants (TrOCs) during anaerobic digestion of primary sludge. Of the 44 TrOCs monitored, 24 were detected in all primary sludge samples. Phase distribution of TrOCs was correlated well with their hydrophobicity (>67% mass in the solid phase when LogD > 1.5). The pilot-scale anaerobic digester achieved a steady performance with a specific methane yield of 0.39-0.92 L/gVSremoved and methane composition of 63-65% despite considerable variation in the primary sludge...
February 10, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29475140/the-prognostic-relevance-of-sentinel-lymph-node-metastases-assessed-by-phgr1-mrna-quantification-in-stage-i-to-iii-colon-cancer
#13
Satu Oltedal, Hartwig Kørner, Ole Gunnar Aasprong, Israr Hussain, Kjersti Tjensvoll, Rune Smaaland, Jon Arne Søreide, Kjetil Søreide, Ragnhild A Lothe, Reino Heikkilä, Bjørnar Gilje, Oddmund Nordgård
BACKGROUND: Regional lymph node (LN) metastasis is a strong and well-established prognostic factor in colon cancer, and recent data suggest a prognostic value of detecting micrometastases and isolated tumor cells in regional LNs. The aim of the study was to investigate the clinical relevance of detecting sentinel lymph node (SLN) metastases in colon cancer patients by measuring the novel metastasis marker PHGR1 mRNA. METHODS: Using quantitative reverse-transcription polymerase chain reaction, we measured PHGR1 mRNA levels in SLNs and primary tumors from 206 patients surgically treated for stage I to III colon cancer and 52 normal LNs from patients undergoing surgery for benign colon diseases...
February 20, 2018: Translational Oncology
https://www.readbyqxmd.com/read/29475134/inhibition-of-phosphodiesterase-4-by-fcpr16-protects-sh-sy5y-cells-against-mpp-induced-decline-of-mitochondrial-membrane-potential-and-oxidative-stress
#14
Jiahong Zhong, Hui Yu, Chang Huang, Qiuping Zhong, Yaping Chen, Jinfeng Xie, Zhongzhen Zhou, Jiangping Xu, Haitao Wang
Phosphodiesterase 4 (PDE4) is a promising target for the treatment of Parkinson's disease (PD). However, the underlying mechanism has not yet been well elucidated. Additionally, most of current PDE4 inhibitors produce severe nausea and vomiting response in patients, which limit their clinical application. FCPR16 is a novel PDE4 inhibitor with little emetic potential. In the present study, the neuroprotective effect and underlying mechanism of FCPR16 against cellular apoptosis induced by 1-methyl-4-phenylpyridinium (MPP+ ) were examined in SH-SY5Y cells...
February 14, 2018: Redox Biology
https://www.readbyqxmd.com/read/29475132/differential-effects-of-short-chain-fatty-acids-on-endothelial-nlrp3-inflammasome-activation-and-neointima-formation-antioxidant-action-of-butyrate
#15
Xinxu Yuan, Lei Wang, Owais M Bhat, Hannah Lohner, Pin-Lan Li
Short chain fatty acids (SCFAs), a family of gut microbial metabolites, have been reported to promote preservation of endothelial function and thereby exert anti-atherosclerotic action. However, the precise mechanism mediating this protective action of SCFAs remains unknown. The present study investigated the effects of SCFAs (acetate, propionate and butyrate) on the activation of Nod-like receptor pyrin domain 3 (Nlrp3) inflammasome in endothelial cells (ECs) and associated carotid neointima formation. Using a partial ligated carotid artery (PLCA) mouse model fed with the Western diet (WD), we found that butyrate significantly decreased Nlrp3 inflammasome formation and activation in the carotid arterial wall of wild type mice (Asc+/+ ), which was comparable to the effect of gene deletion of the adaptor protein apoptosis-associated speck-like protein gene (Asc-/- )...
February 13, 2018: Redox Biology
https://www.readbyqxmd.com/read/29475129/effects-of-short-term-feeding-of-different-sources-of-fatty-acids-in-pre-mating-diets-on-reproductive-performance-and-blood-metabolites-of-fat-tailed-iranian-afshari-ewes
#16
H Mirzaei-Alamouti, Z Mohammadi, M H Shahir, M Vazirigohar, M Mansouryar
The effects of dietary omega-3 and omega-6 fatty acids (FAs) in pre-mating diets on reproductive performances and metabolic status of ewes have not been well investigated. Therefore, this study investigated the effect of supplementing different source of FAs on different aspects of reproductive performance of fat-tailed Iranian Afshari ewes. Thirty-two cycling, multiparous Afshari ewes were divided into four groups and fed one of the isocaloric and isonitrogenous diets supplemented with Sunflower oil (SFO), Fish oil (FO), calcium salt of palm oil (CaPO) and/or an equal mixture of SFO + FO (SFOFO)...
February 15, 2018: Theriogenology
https://www.readbyqxmd.com/read/29475119/the-correlation-of-morphological-and-thrombotic-villous-arterial-lesions-with-fetal-doppler-echocardiographic-measurements-in-the-placentas-of-low-risk-term-pregnancies
#17
Katsuyuki Sekii, Chizuko Yaguchi, Hiroaki Itoh
OBJECTIVE: Few studies have correlated the placental vasculature with fetal cardiac function other than umbilical artery Doppler assessment in low-risk pregnancies. We assessed the contribution of the placental vasculature to fetal echocardiographic parameters using histopathological and morphometric analyses of placental resistance arteries. STUDY DESIGN: Thirty-four low-risk singleton term pregnancies were assessed, including 24 thrombosis-negative cases (no/minimal gross and histological placental abnormalities) and 10 thrombosis-positive cases (histologically identified chorionic plate/stem vessel thrombosis)...
February 14, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29475117/effects-of-soil-depth-and-plant-soil-interaction-on-microbial-community-in-temperate-grasslands-of-northern-china
#18
Xiaodong Yao, Naili Zhang, Hui Zeng, Wei Wang
Although the patterns and drivers of soil microbial community composition are well studied, little is known about the effects of plant-soil interactions and soil depth on soil microbial distribution at a regional scale. We examined 195 soil samples from 13 sites along a climatic transect in the temperate grasslands of northern China to measure the composition of and factors influencing soil microbial communities within a 1-m soil profile. Soil microbial community composition was measured using phospholipid fatty acids (PLFA) analysis...
February 20, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29475114/experimental-and-simulation-study-of-the-restoration-of-a-thallium-i-contaminated-aquifer-by-permeable-adsorptive-barriers-pabs
#19
G F Santonastaso, A Erto, I Bortone, S Chianese, A Di Nardo, D Musmarra
Permeable Adsorptive Barriers (PABs), filled with a commercial activated carbon, are tested as a technique for the remediation of a thallium (I)-contaminated aquifer located in the south of Italy. Thallium adsorption capacity of the activated carbon is experimentally determined through dedicated laboratory tests, allowing to obtain the main modelling parameters to describe the adsorption phenomena within the barrier. A 2D numerical model, solved by using a finite element approach via COMSOL Multi-physics®, is used to simulate the contaminant transport within the aquifer and for the PAB design...
February 20, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29475112/what-s-the-point-the-contribution-of-a-sustainability-view-in-contaminated-site-remediation
#20
Robert Anderson, Jenny Norrman, Pär-Erik Back, Tore Söderqvist, Lars Rosén
Decision support tools (DST) are often used in remediation projects to aid in the complex decision on how best to remediate a contaminated site. In recent years, the sustainable remediation concept has brought increased attention to the often-overlooked contradictory effects of site remediation, with a number of sustainability assessment tools now available. The aim of the present study is twofold: (1) to demonstrate how and when different assessment views affect the decision support outcome on remediation alternatives in a DST, and (2) to demonstrate the contribution of a full sustainability assessment...
February 20, 2018: Science of the Total Environment
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