keyword
MENU ▼
Read by QxMD icon Read
search

Wells

keyword
https://www.readbyqxmd.com/read/29925119/-research-on-participation-in-working-life-on-the-transfer-from-theory-into-practice
#1
Susanne Bartel, Heike Ohlbrecht
OBJECTIVE: This study focuses on the theory-practice transfer in the field of research on participation in working life (LTA). The aim was to determine what expectations are prevalent on the part of service providers, how they access scientific knowledge, how the transfer into practice takes place and what research gaps exist. At the same time, representatives of the German Statutory Pension Insurance were asked about internal structures for identifying research topics and evaluating research results as well as for knowledge transfer...
June 2018: Die Rehabilitation
https://www.readbyqxmd.com/read/29925116/-trajectories-and-biographical-constellations-in-a-long-term-study-on-vocational-retraining-and-their-effects-on-return-to-work-and-sustainable-stay-at-work
#2
Sebastian Klaus, Alexander Meschnig, Ernst von Kardorff
OBJEKTIVES: Using qualitative-hermeneutical methods with a focus on biographical (risk-) constellations for conditions of success or failure of return to work - and therefore on the efficiency and sustainability of employment participation benefits - the study accompanies participants during a time span of 2 years after their vocational retraining on their way back into the first labor market. METHODS: The study applies a mixed method design which combines 30 episodical-narrative interviews of participating rehabilitants alongside with a questionnaire survey of a total of 214 participants and 19 interviews of scientists and vocational retraining experts...
June 2018: Die Rehabilitation
https://www.readbyqxmd.com/read/29925115/-return-to-work-and-stay-at-work-the-question-of-successful-operational-integration-management
#3
Heike Ohlbrecht, Carsten Detka, Susanne Kuczyk, Bianca Lange
OBJECTIVE: The study focuses on the question of how the design of operational integration management (OIM) can be optimized, especially in small and medium-sized enterprises (SMEs), and how previous experience with operational integration management can be used to develop preventive measures to ensure employability. METHODS: The study follows a multi-perspective qualitative research design. It focused on the survey of 40 retrospective interviews with employees who have undergone different variants of the OIM...
June 2018: Die Rehabilitation
https://www.readbyqxmd.com/read/29925097/-quality-and-satisfaction-with-the-surgical-medical-clerkship-from-a-student-perspective
#4
Susanne Froehlich, Florian Goebel, Adrian Meder, Janine Wirkner, Udo Obertacke, Richard Kasch
PREFACE: The surgical medical clerkship is of special importance, as the student is given the opportunity to get in touch with medical colleagues and patients for the first time, and the interest in a certain field of specialisation can be consolidated. The present study will clarify how students perceived their medical clerkship in the field of surgery. METHODS: A nationwide online survey carried out in 2012 was able to recruit 9079 participants, and contained questions about the completed curricular internships...
June 20, 2018: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29925086/participant-perspectives-of-a-6-month-telephone-based-lifestyle-coaching-program
#5
Bronwyn McGill, Blythe J O'Hara, Philayrath Phongsavan
Objectives and importance of study: Low program completion rates can undermine the public health impact of even the most effective program. Participant experiences with lifestyle programs are not well reported, but are important for program improvement and retention. The purpose of this study was to understand participant perceptions of the Get Healthy Information and Coaching Service (GHS), a 6-month telephone-based health coaching program to promote lifestyle change. We were particularly interested in participants' initial expectations, their actual experience and, for those who did not complete the program, what influenced their withdrawal...
June 14, 2018: Public Health Research & Practice
https://www.readbyqxmd.com/read/29925081/how-can-communities-and-organisations-improve-their-health-literacy
#6
Jane Lloyd, Louise Thomas, Gawaine Powell-Davies, Regina Osten, Mark Harris
Definitions of health literacy have tended to focus on the abilities of patients and communities, rather than on the ability of the health system and its services to respond to patients' different levels of health literacy. However, health literacy is increasingly being recognised as part of a dynamic, two-way relationship, affected by both organisational factors (e.g. tailoring of communication and care to patients' needs) and community factors (e.g. individuals' ability to perceive and seek care). Developing a more comprehensive understanding of health literacy is an important step towards improving health literacy...
June 14, 2018: Public Health Research & Practice
https://www.readbyqxmd.com/read/29925066/the-vasopressin-system-in-the-risk-of-diabetes-and-cardiorenal-disease-and-hydration-as-a-potential-lifestyle-intervention
#7
Sofia Enhörning, Olle Melander
BACKGROUND: Type 2 diabetes, chronic kidney disease (CKD) and its cardiovascular complications are increasing as health problems worldwide. These diseases are interrelated with overlapping occurrence and once diabetes is established, the risk of cardiorenal disease is dramatically elevated. Thus, a search for unifying modifiable risk factors is key for effective prevention. SUMMARY: Elevated fasting plasma concentration of vasopressin, measured with the marker copeptin, predicts new onset type 2 diabetes as well as renal function decline...
2018: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/29925064/once-weekly-administration-of-sustained-release-growth-hormone-in-korean-prepubertal-children-with-idiopathic-short-stature-a-randomized-controlled-phase-ii-study
#8
Jin Soon Hwang, Hae Sang Lee, Kee-Hyoung Lee, Han-Wook Yoo, Dae-Yeol Lee, Byung-Kyu Suh, Cheol Woo Ko, Woo Yeong Chung, Dong-Kyu Jin, Choong Ho Shin, Heon-Seok Han, Song Han, Ho-Seong Kim
BACKGROUND/AIMS: To determine the optimal dose of LB03002, a sustained-release, once-weekly formulation of recombinant human growth hormone (rhGH), and to compare its efficacy and safety with daily rhGH in children with idiopathic short stature (ISS). METHODS: This multicenter, randomized, open-label, phase II study included GH-naïve, prepubertal children with ISS, randomized to receive daily rhGH 0.37 mg/kg/week (control, n = 16), LB03002 0.5 mg/kg/week (n = 14), or LB03002 0...
June 20, 2018: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/29925063/targeting-shp-1-2-and-ship-pathways-a-novel-strategy-for-cancer-treatment
#9
REVIEW
Wolfram C M Dempke, Peter Uciechowski, Klaus Fenchel, Timothy Chevassut
Well-balanced levels of tyrosine phosphorylation, maintained by the reversible and coordinated actions of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs), are critical for a wide range of cellular processes including growth, differentiation, metabolism, migration, and survival. Aberrant tyrosine phosphorylation, as a result of a perturbed balance between the activities of PTKs and PTPs, is linked to the pathogenesis of numerous human diseases, including cancer, suggesting that PTPs may be innovative molecular targets for cancer treatment...
June 20, 2018: Oncology
https://www.readbyqxmd.com/read/29925061/robotic-head-and-neck-surgery-history-technical-evolution-and-the-future
#10
George Garas, Asit Arora
The first application of robotic technology in surgery was described in 1985 when a robot was used to define the trajectory for a stereotactic brain biopsy. Following its successful application in a variety of surgical operations, the da Vinci® robot, the most widely used surgical robot at present, made its clinical debut in otorhinolaryngology and head and neck surgery in 2005 when the first transoral robotic surgery (TORS) resections of base of tongue neoplasms were reported. Subsequently, the indications for TORS rapidly expanded, and they now include tumours of the oropharynx, hypopharynx, parapharyngeal space, and supraglottic larynx, as well as obstructive sleep apnoea (OSA)...
June 20, 2018: ORL; Journal for Oto-rhino-laryngology and its related Specialties
https://www.readbyqxmd.com/read/29925060/comparative-effects-of-topical-0-2-sirolimus-for-angiofibromas-in-adults-and-pediatric-patients-with-tuberous-sclerosis-complex
#11
Young In Lee, Ju Hee Lee, Do Young Kim, Kee Yang Chung, Jung U Shin
BACKGROUND: Recent reports have suggested that the topical formulation of sirolimus is effective in treating facial angiofibromas in tuberous sclerosis complex (TSC). Here, we determined the safety and efficacy of 0.2% topical sirolimus for the treatment of facial angiofibroma and compared its effects based on age. METHOD: This was a retrospective study which involved 36 TSC patients with facial angiofibromas who were treated with 0.2% sirolimus ointment. Its effect was evaluated using the Facial Angiofibroma Severity Index (FASI)...
June 20, 2018: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/29925059/morphological-characterization-of-basally-located-uninucleate-trophoblast-cells-as-precursors-of-bovine-binucleate-trophoblast-giant-cells
#12
Jeannette Attiger, Alois Boos, Karl Klisch
Binucleate trophoblast giant cells (TGCs) are one characteristic feature of the ruminant placenta. In cows, the frequency of TGCs remains constant for most of the duration of pregnancy. As TGCs are depleted by their fusion with uterine epithelial cells, they need to be constantly formed. It is still unclear whether they develop from stem cells within the trophectoderm or whether they can arise from any uninucleate trophoblast cell (UTC). Within the latter, generally accepted theory, a basally located uninucleate cell (BUC) without contact to the feto-maternal interface would represent a transient cell between a UTC and a TGC...
June 20, 2018: Cells, Tissues, Organs
https://www.readbyqxmd.com/read/29925057/pollution-characteristics-and-health-risk-assessment-of-heavy-metals-in-the-vegetable-bases-of-northwest-china
#13
Rukeya Sawut, Nijat Kasim, Balati Maihemuti, Li Hu, Abdugheni Abliz, Abdusalam Abdujappar, Miradil Kurban
The objective of this study was to investigate heavy metal contamination in four major vegetable bases and determine the health risks of residents in the vicinity of the highly urbanized city Urumqi in Xinjiang, China. In this paper, we determined the contents of six heavy metals (i.e., As, Zn, Cd, Cr, Hg, and Pb) in surface soil and groundwater to evaluate the levels of heavy metal pollution and human health risks using the pollution index (PI), the Nemerow integrated pollution index (NIPI), the ecological risk factor (Ei r ), risk index (RI) and the health risk assessment model...
June 17, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29925047/nitric-oxide-mitigates-the-effect-of-water-deficit-in-crambe-abyssinica
#14
Priscila Ferreira Batista, Alan Carlos Costa, Caroline Müller, Robson de Oliveira Silva-Filho, Fábia Barbosa da Silva, Andrew Merchant, Giselle Camargo Mendes, Kelly Juliane Telles Nascimento
Crambe abyssinica is widely cultivated in the off-season in the Midwest region of Brazil with great potential for biodeisel production. Low precipitation is characteristic of this region, which can drastically affect the productivity of C. abyssinica. Signaling molecules, such as nitric oxide (NO), can potentially alleviate the effects of water stress on plants. Here we test whether nitric oxide, applied by donor sodium nitroprusside (SNP), can alleviate the occurrence of water deficit damages in Crambe plants and maintain physiological and biochemical processes...
June 12, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29925044/a-systematic-review-of-patient-reported-outcomes-in-phase-ii-or-iii-clinical-trials-of-myelodysplastic-syndromes-and-acute-myeloid-leukemia
#15
REVIEW
Ashley Leak Bryant, Sarah W Drier, Sejin Lee, Antonia V Bennett
The purpose of this systematic literature review was to identify clinical trials of MDS and AML that included patient-reported outcome (PRO) instruments, and to summarize the symptom and other health related quality of life (HRQOL) concepts most frequently assessed and the PRO instruments that were used. Sixteen manuscripts describing 14 distinct trials met all criteria (i.e., phase 2 or 3 clinical trial for MDS or AML which included PRO assessment) and were published between 1996-2017. In trials evaluating anemia, PRO scores showed significant improvement in relevant domains (e...
June 7, 2018: Leukemia Research
https://www.readbyqxmd.com/read/29925042/sirt2-promotes-the-migration-and-invasion-of-gastric-cancer-through-ras-erk-jnk-mmp-9-pathway-by-increasing-pepck1-related-metabolism
#16
Yang Li, Mingming Zhang, Robert G Dorfman, Yida Pan, Dehua Tang, Lei Xu, Zhenguo Zhao, Qian Zhou, Lixing Zhou, Yuming Wang, Yuyao Yin, Shanshan Shen, Bo Kong, Helmut Friess, Shimin Zhao, Lei Wang, Xiaoping Zou
Metastasis is the most important feature of gastric cancer (GC) and the most widely recognized reason for GC-related deaths. Unfortunately, the underlying mechanism behind this metastasis remains unknown. Mounting evidence suggests the dynamic regulatory role of sirtuin2 (SIRT2), a histone deacetylase (HDAC), in cell migration and invasion. The present study aims to evaluate the biological function of SIRT2 in GC and identify the target of SIRT2 as well as evaluate its therapeutic efficacy. We found that SIRT2 was upregulated in GC tissues compared to adjacent normal tissues, and this was correlated with reduced patient survival...
June 17, 2018: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/29925036/converting-lignin-derived-phenolic-aldehydes-into-microbial-lipid-by-trichosporon-cutaneum
#17
Mingshan Hu, Juan Wang, Qiuqiang Gao, Jie Bao
Lignin is one of the major components of lignocellulose biomass and chemically degrades into phenolic aldehydes including 4-hydroxybenzaldehyde, vanillin, and syringaldehyde. No lipid accumulation from the phenolic aldehydes by oleaginous microbes had been succeeded. Compared with vanillin and syringaldehyde, T. cutaneum ACCC 20271 have better tolerance to 4-hydroxybenzaldehyde. 4-Hydroxybenzaldehyde was found to be able as the substrate for lipid accumulation, while vanillin and syringaldehyde were only converted to less toxic phenolic alcohols and acids without observable lipid accumulation, perhaps due to the space shelling of methoxyl group(s) in the structures...
June 17, 2018: Journal of Biotechnology
https://www.readbyqxmd.com/read/29925035/molecular-filters-for-noise-reduction
#18
Luca Laurenti, Attila Csikasz-Nagy, Marta Kwiatkowska, Luca Cardelli
Living systems are inherently stochastic and operate in a noisy environment, yet despite all these uncertainties, they perform their functions in a surprisingly reliable way. The biochemical mechanisms used by natural systems to tolerate and control noise are still not fully understood, and this issue also limits our capacity to engineer reliable, quantitative synthetic biological circuits. We study how representative models of biochemical systems propagate and attenuate noise, accounting for intrinsic as well as extrinsic noise...
June 19, 2018: Biophysical Journal
https://www.readbyqxmd.com/read/29925025/membrane-diffusion-occurs-by-continuous-time-random-walk-sustained-by-vesicular-trafficking
#19
Maria Goiko, John R de Bruyn, Bryan Heit
Diffusion in cellular membranes is regulated by processes that occur over a range of spatial and temporal scales. These processes include membrane fluidity, interprotein and interlipid interactions, interactions with membrane microdomains, interactions with the underlying cytoskeleton, and cellular processes that result in net membrane movement. The complex, non-Brownian diffusion that results from these processes has been difficult to characterize, and moreover, the impact of factors such as membrane recycling on membrane diffusion remains largely unexplored...
June 19, 2018: Biophysical Journal
https://www.readbyqxmd.com/read/29925022/fscs-reveals-the-complexity-of-lipid-domain-dynamics-in-the-plasma-membrane-of-live-cells
#20
Philip R Nicovich, Joanna M Kwiatek, Yuanqing Ma, Aleš Benda, Katharina Gaus
The coexistence of lipid domains with different degrees of lipid packing in the plasma membrane of mammalian cells has been postulated, but direct evidence has so far been challenging to obtain because of the small size and short lifetime of these domains in live cells. Here, we use fluorescence spectral correlation spectroscopy in conjunction with a probe sensitive to the membrane environment to quantify spectral fluctuations associated with dynamics of membrane domains in live cells. With this method, we show that membrane domains are present in live COS-7 cells and have a lifetime lower bound of 5...
June 19, 2018: Biophysical Journal
keyword
keyword
41233
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"