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Staphylcoccus

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https://www.readbyqxmd.com/read/27572414/cefazolin-and-ertapenem-a-synergistic-combination-used-to-clear-persistent-staphylococcus-aureus-bacteremia
#1
George Sakoulas, Joshua Olson, Juwon Yim, Niedita B Singh, Monika Kumaraswamy, Diana T Quach, Michael J Rybak, Joseph Pogliano, Victor Nizet
BACKGROUND: Ertapenem and cefazolin were used in combination to successfully clear refractory methicillin-susceptible Staphylcoccus aureus (MSSA) bacteremia. In addition, recent work has demonstrated acitivity of combination beta-lactam therapy from different classes against MRSA. METHODS: Ertapenem plus cefazolin combination was evaluated for synergy in vitro and in vivo in a murine skin infection model using an index MSSA bloodstream isolate from a patient in whom persistent bacteremia was cleared with this combination, and against a cadre of well-described research strains and clinical strains of MSSA and MRSA...
August 29, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27557072/-patient-from-gambia-with-sonographic-white-kidneys
#2
Eva Aebert, Maike Büttner-Herold, Frederick Pfister, Thomas Mühlbacher, Christoph Berg, Martin Müller, Michael Haap, Ferruh Artunc
HISTORY AND ADMISSION FINDINGS: A 39-year-old male refugee from Gambia is admitted to the emergency room with fever, body aches and productive cough. INVESTIGATIONS: Laboratory, ultrasound and CT investigations show a sepsis due to Staphylcoccus aureus, a renal failure with the appearance of "snow-white" kidneys on ultrasound and a previously unknown acute HIV-infection. DIAGNOSIS, TREATMENT AND COURSE: Broad antibiotic treatment and an antiretroviral therapy (adapted to the impaired renal function) as well as hemodialysis are commenced...
August 2016: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/26677256/clinical-and-molecular-characterization-of-invasive-heteroresistant-vancomycin-intermediate-staphylococcus-aureus-infections-in-korean-hospitals
#3
Eu Suk Kim, In-Gyu Bae, Jeong Eun Cho, Yun Jung Choi, Il-Hwan Kim, Gi-Su Kang, Hye-yun Sin, Kyoung-Ho Song, Chulmin Park, Dong-Gun Lee, Moonsuk Kim, Kyoung Un Park, Hong Bin Kim
Invasive heteroresistant vancomycin-intermediate Staphylococcus aureus (h-VISA) isolates were identified and characterized in 10 Korean hospitals from July 2009 to June 2011. The prevalence of h-VISA infections was 3.3% (42/1,289). Most (41/42) were health care-associated infections caused by strains belonging to sequence type 5. Cases of persistent bacteremia were frequent (17/42), and 30-day mortality was high (16/40).
March 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/26676553/microbiology-and-resistance-in-first-episodes-of-spontaneous-bacterial-peritonitis-implications-for-management-and-prognosis
#4
Kilian Friedrich, Simone Nüssle, Tobias Rehlen, Wolfgang Stremmel, Alexander Mischnik, Christoph Eisenbach
PURPOSE: International guidelines for antibiotic treatment of spontaneous bacterial peritonitis (SBP) are based on studies conducted decades ago and do not reflect regional differences of bacterial epidemiology. METHODS: We retrospectively analyzed epidemiology of agents, antibiotic resistance patterns, and survival in liver cirrhosis patients with their first episode of SBP during the years 2007-2013. RESULTS: Of the 311 patients included, 114 patients had a positive ascites culture, and 197 had an ascitic neutrophil count >250 μL...
June 2016: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/26184235/laminarin-from-irish-brown-seaweeds-ascophyllum-nodosum-and-laminaria-hyperborea-ultrasound-assisted-extraction-characterization-and-bioactivity
#5
Shekhar U Kadam, Colm P O'Donnell, Dilip K Rai, Mohammad B Hossain, Catherine M Burgess, Des Walsh, Brijesh K Tiwari
Ultrasound assisted extraction (UAE), purification, characterization and antioxidant activity of laminarin from Irish brown seaweeds Ascophyllum nodosum and Laminarina hyperborea were investigated. UAE was carried out using 60% ultrasonic power amplitude and 0.1 M hydrochloric acid for 15 min. Separately, solid-liquid extraction was carried in an orbital shaker using 0.1 M hydrochloric acid at 70 °C for 2.5 h. UAE with hydrochloric acid resulted in the highest concentration of laminarin, 5.82% and 6.24% on dry weight basis from A...
July 2015: Marine Drugs
https://www.readbyqxmd.com/read/25203593/collagenases-in-an-ether-extract-of-bacterial-metabolites-used-as-an-immunostimulator-induces-tnf-%C3%AE-and-ifn-%C3%AE
#6
Namrata Singh, Debasish Bhattacharyya
Non-specific immunostimulation by bacterial extracts and their components are widely accepted for the prevention and treatment of several infectious diseases. An ether extract of the metabolites of ß-streptococcus, Staphylcoccus albus, Staphylcoccus aureus, Escherichia coli, Haemophilus influenza, Moraxella caterhalis, Salmonella typhi (standard O & H), Salmonella paratyphi (A & B) and Diptheroid bacilli along with bile lipids is used as a licensed drug for immunostimulation. While characterizing the drug, we observed gelatinolytic/collagenolytic activity in the ether extract by zymography...
November 2014: International Immunopharmacology
https://www.readbyqxmd.com/read/24887230/bacterial-screening-of-platelet-concentrates-on-day-2-and-3-with-flow-cytometry-the-optimal-sampling-time-point
#7
Tanja Vollmer, Volkmar Schottstedt, Juergen Bux, Gabriele Walther-Wenke, Cornelius Knabbe, Jens Dreier
BACKGROUND: There is growing concern on the residual risk of bacterial contamination of platelet concentrates in Germany, despite the reduction of the shelf-life of these concentrates and the introduction of bacterial screening. In this study, the applicability of the BactiFlow flow cytometric assay for bacterial screening of platelet concentrates on day 2 or 3 of their shelf-life was assessed in two German blood services. The results were used to evaluate currently implemented or newly discussed screening strategies...
July 2014: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/24494859/dynamics-of-methicillin-resistant-staphylococcus-aureus-and-methicillin-susceptible-staphylococcus-aureus-carriage-in-pig-farmers-a-prospective-cohort-study
#8
B A G L van Cleef, B H B van Benthem, E J M Verkade, M van Rijen, M F Q Kluytmans-van den Bergh, L M Schouls, B Duim, J A Wagenaar, H Graveland, M E H Bos, D Heederik, J A J W Kluytmans
Our purpose was to determine the dynamics of livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) carriage and its determinants in persons working at pig farms, in order to identify targets for interventions. This prospective cohort study surveyed 49 pig farms in the Netherlands on six sampling dates in 1 year (2010-11). Nasal and oropharyngeal swabs were collected, as well as environmental surface samples from stables and house. Of 110 pig farmers, 38% were persistent MRSA nasal carriers...
October 2014: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/23465690/chocolate-consumption-modulates-cytokine-production-in-healthy-individuals
#9
Stejara A Netea, Sam A Janssen, Martin Jaeger, Trees Jansen, Liesbeth Jacobs, Gosia Miller-Tomaszewska, Theo S Plantinga, Mihai G Netea, Leo A B Joosten
Epidemiological studies suggest that chocolate increases the incidence and severity of acne. Here we demonstrate that chocolate consumption primes human blood mononuclear cells from volunteers to release more interleukin-1β (IL-1β) and IL-10 upon stimulation with Propionibacterium acne or Staphylcoccus aureus, the two microorganisms involved in the pathogenesis of acne. In contrast, production of the Th17-derived cytokine IL-22 was inhibited by chocolate. Modulation of inflammation could represent an important mechanism through which chocolate consumption influences acne...
April 2013: Cytokine
https://www.readbyqxmd.com/read/23263995/moxa-stick-suffumigation-for-disinfecting-air-in-hematology-and-hematopoietic-stem-cell-transplantation-wards-with-class-100-laminar-flow
#10
Jing-song He, Qing Yang, Wei-jia Huang, Xiao-rong Hu
OBJECTIVE: To evaluate the effect of moxa-stick suffumigation in the hematology and hematopoietic stem cell transplantation (HSCT) wards with luminar flow. METHODS: The plate exposure method was used to measure the effect of air-disinfection of moxa-stick suffumigation in hematology and HSCT wards. The yearly average qualified rates of air sampling in HSCT wards were evaluated from 2007 to 2010. To further investigate the disinfecting effect of moxa-stick suffumigation, the colony counts of common pathogens (including Staphylcoccus aureus and Pseudomonas aeruginosa) before and after moxa-stick suffumigation were compared...
April 2014: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/23255621/genomic-characterization-of-lytic-staphylococcus-aureus-phage-gh15-providing-new-clues-to-intron-shift-in-phages
#11
Jingmin Gu, Xiaohe Liu, Mei Yang, Yue Li, Changjiang Sun, Rong Lu, Jun Song, Qingming Zhang, Liancheng Lei, Xin Feng, Chongtao Du, Hao Yu, Yongjun Yang, Wenyu Han
Phage GH15 is a polyvalent phage that shows activity against a wide range of Staphylcoccus aureus strains. This study analysed the genome of GH15. The genome size of GH15 (139 806 bp) was found to be larger than that of the known staphylococcal phages, and the G+C content (30.23 mol%) of GH15 was lower than that of any other staphylococcal myovirus phages. By mass spectrometry, ten structural proteins were identified. Analysis revealed that GH15 was closely related to phages G1, ISP, A5W, Sb-1 and K, and was moderately related to Twort...
April 2013: Journal of General Virology
https://www.readbyqxmd.com/read/23201728/effect-of-rhamnolipids-on-initial-attachment-of-bacteria-on-glass-and-octadecyltrichlorosilane-modified-glass
#12
Maysam Sodagari, Hua Wang, Bi-min Zhang Newby, Lu-Kwang Ju
Bacterial attachment on solid surfaces has various implications in environmental, industrial and medical applications. In this study, the effects of rhamnolipid biosurfactants on initial attachment of bacteria on hydrophilic glass and hydrophobic octadecyltrichlorosilane (OTS) modified glass were evaluated under continuous-flow conditions. The bacteria investigated were three Gram-negative species Pseudomonas aeruginosa, Pseudomonas putida, and Escherichia coli, and two Gram-positive species Staphylcoccus epidermidis and Bacillus subtilis...
March 1, 2013: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/22362863/protection-against-staphylococcus-aureus-by-antibody-to-the-polyglycerolphosphate-backbone-of-heterologous-lipoteichoic-acid
#13
Christian Theilacker, Andrea Kropec, Felix Hammer, Irina Sava, Dominique Wobser, Tuerkan Sakinc, Jeroen D C Codée, Wouter F J Hogendorf, Gijsbert A van der Marel, Johannes Huebner
Type 1 lipoteichoic acid (LTA) is present in many clinically important gram-positive bacteria, including enterococci, streptococci, and staphylococci, and antibodies against LTA have been shown to opsonize nonencapsulated Enterococcus faecalis strains. In the present study, we show that antibodies against E. faecalis LTA also bind to type 1 LTA from other gram-positive species and opsonized Staphylocccus epidermidis and Staphylcoccus aureus strains as well as group B streptococci. Inhibition studies using teichoic acid oligomers indicated that cross-reactive opsonic antibodies bind to the teichoic acid backbone...
April 1, 2012: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/21984272/high-prevalence-of-methicillin-resistant-staphylococcus-aureus-among-residents-and-staff-of-long-term-care-facilities-involving-joint-and-parallel-evolution
#14
Mitchell J Schwaber, Samira Masarwa, Shiri Navon-Venezia, Yael Kandlik, Inna Chmelnitsky, Gill Smollan, Rivka Glick, Gila Neria, Yehuda Carmeli
Six long-term care facilities were surveyed for methicillin-resistant Staphylcoccus aureus (MRSA). Among 191 residents, 14% were carriers; 1 strain predominated (ST5-SCCmec II). Among 132 staff members, 11% were positive; 2 strains predominated (ST5-SCCmec II, ST8-SCCmec IV). All strains were Panton-Valentine leukocidin-negative. The epidemiology of MRSA among residents and staff involved joint and parallel evolution.
November 2011: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/21282987/incidence-occurrence-rate-and-characteristics-of-suture-related-corneal-infections-after-penetrating-keratoplasty
#15
Christopher T Hood, Brian J Lee, Bennie H Jeng
PURPOSE: To report the incidence, occurrence rate, and characteristics of suture-related infections after penetrating keratoplasty (PK). METHODS: Patients who underwent PK at our institution between January 1, 2002, and July 1, 2006, were cross-referenced with patients diagnosed with corneal infections between January 1, 2002, and July 1, 2007. All patient charts were reviewed retrospectively for occurrence of suture-related infections, duration of follow-up, and clinical characteristics...
June 2011: Cornea
https://www.readbyqxmd.com/read/20153070/food-borne-diseases-the-challenges-of-20-years-ago-still-persist-while-new-ones-continue-to-emerge
#16
REVIEW
Diane G Newell, Marion Koopmans, Linda Verhoef, Erwin Duizer, Awa Aidara-Kane, Hein Sprong, Marieke Opsteegh, Merel Langelaar, John Threfall, Flemming Scheutz, Joke van der Giessen, Hilde Kruse
The burden of diseases caused by food-borne pathogens remains largely unknown. Importantly data indicating trends in food-borne infectious intestinal disease is limited to a few industrialised countries, and even fewer pathogens. It has been predicted that the importance of diarrhoeal disease, mainly due to contaminated food and water, as a cause of death will decline worldwide. Evidence for such a downward trend is limited. This prediction presumes that improvements in the production and retail of microbiologically safe food will be sustained in the developed world and, moreover, will be rolled out to those countries of the developing world increasingly producing food for a global market...
May 30, 2010: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/19870903/the-production-of-kidney-antibodies-by-injection-of-homologous-kidney-plus-bacterial-toxins
#17
F F Schwentker, F C Comploier
Rabbits injected with emulsions of homologous kidney to which staphylcoccus or streptococcus toxins had been added produced complement fixing antibodies which reacted with both rabbit kidney and brain. By absorption tests it was demonstrated that the sera contained at least two antibodies, one specific for kidney, the other non-specific. Similar kidney antibodies were found in the blood of a majority of patients with scarlet fever but in only a few normal persons. The possibility that a similar or related antibody may be concerned in the etiology of scarlatinal nephritis is discussed...
August 31, 1939: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/19226421/population-based-epidemiology-of-staphylococcus-aureus-bloodstream-infection-in-canterbury-new-zealand
#18
COMPARATIVE STUDY
P J Huggan, J E Wells, M Browne, A Richardson, D R Murdoch, S T Chambers
BACKGROUND: Few contemporary reports describe population-based incidence of Staphylcoccus aureus bloodstream infection (SABSI). AIM: To describe longitudinal incidence of SABSI in a region of New Zealand with low MRSA prevalence. METHODS: Blood cultures growing S. aureus were identified from hospital laboratories between 1 July 1998 and 30 June 2006. Record linkage was used to combine information from local and national databases into a single patient event record...
February 2010: Internal Medicine Journal
https://www.readbyqxmd.com/read/19097807/secondary-infections-of-thoracic-and-abdominal-aortic-endografts
#19
Kamaldeep S Heyer, Parth Modi, Mark D Morasch, Jon S Matsumura, Melina R Kibbe, William H Pearce, Scott A Resnick, Mark K Eskandari
PURPOSE: To review several cases of stent-graft infection with respective outcomes to identify clinical presentations and responses to treatment options. MATERIALS AND METHODS: The authors performed a single-center retrospective review of all secondary endograft infections from January 2000 to June 2007. Infections were identified from an institutional database containing all abdominal and thoracic endovascular aneurysm repairs (EVAR and TEVAR) performed at the treating hospital...
February 2009: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/18692591/mgra-regulates-staphylococcal-virulence-important-for-induction-and-progression-of-septic-arthritis-and-sepsis
#20
Ing-Marie Jonsson, Catharina Lindholm, Thanh T Luong, Chia Y Lee, Andrej Tarkowski
Septic arthritis and sepsis are common and feared complications of staphylococcal infections, and the increasing antibiotic resistance among staphylococci urge the extended research for virulence factors involved in these diseases. Staphylcoccus aureus produces a number of virulence factors controlled by several global regulatory genes including agr and sarA. MgrA is a recently identified global regulator, belonging to the SarA subfamily, which upregulates expression of several virulence factors including capsule and sortase...
October 2008: Microbes and Infection
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