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https://www.readbyqxmd.com/read/28549221/preventing-underfeeding-and-overfeeding-a-clinician-s-guide-to-the-acquisition-and-implementation-of-indirect-calorimetry
#1
Amy K Ladd, Heather E Skillman, Matthew A Haemer, Peter M Mourani
BACKGROUND: In critically ill patients, indirect calorimetry (IC) is the gold standard to determine energy needs, as the use of predictive equations can result in underfeeding or overfeeding. The aim of this quality improvement (QI) initiative was to describe the rationale for and implementation of a process to target energy provision according to IC measurements in a tertiary academic medical center pediatric intensive care unit (PICU). MATERIALS AND METHODS: To justify the purchase of an indirect calorimeter for clinical use, a needs assessment was conducted, followed by a training and implementation period...
May 1, 2017: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/28549105/outbreak-of-pneumocystis-jirovecii-infection-among-heart-transplant-recipients-molecular-investigation-and-management-of-an-inter-human-transmission
#2
William Vindrios, Nicolas Argy, Solène Le Gal, François-Xavier Lescure, Laurent Massias, Minh Patrick Le, Michel Wolff, Yazdan Yazdanpanah, Gilles Nevez, Sandrine Houze, Richard Dorent, Jean-Christophe Lucet
Background: An outbreak of Pneumocystis jirovecii pneumonia (PCP) occurred among heart transplant recipients (HTR) at the outpatient clinic of a university hospital, from March to September 2015. Clinical, therapeutic, biological and molecular data were analyzed to determine its origin and control the outbreak. Methods: Clinical and biological data regarding all HTR followed in the outpatient clinic were collected. PCP diagnosis was based on microscopy and real-time PCR...
May 26, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28549097/cluster-of-neisseria-gonorrhoeae-isolates-with-high-level-azithromycin-resistance-and-decreased-ceftriaxone-susceptibility-hawaii-2016
#3
Alan R Katz, Alan Y Komeya, Robert D Kirkcaldy, A Christian Whelen, Olusegun O Soge, John R Papp, Ellen N Kersh, Glenn M Wasserman, Norman P O'Connor, Pamela S O'Brien, Douglas T Sato, Eloisa V Maningas, Gail Y Kunimoto, Juval E Tomas
Background.: The Centers for Disease Control and Prevention (CDC) currently recommends dual therapy with ceftriaxone and azithromycin for gonorrhea to ensure effective treatment and slow emergence of antimicrobial resistance. Since 2013, the prevalence of reduced azithromycin susceptibility increased in the United States; however, these strains were highly susceptible to cephalosporins. We report on a cluster of N. gonorrhoeae isolates demonstrating high-level azithromycin resistance, several of which also demonstrated decreased ceftriaxone susceptibility...
May 26, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28549011/use-of-elderly-donors-in-liver-transplantation-a-paired-match-analysis-at-a-single-center
#4
Davide Ghinolfi, Quirino Lai, Daniele Pezzati, Paolo De Simone, Erion Rreka, Franco Filipponi
OBJECTIVE: To evaluate the use of elderly donors in liver transplantation (LT) and identify risk factors associated with a worse outcome. SUMMARY BACKGROUND DATA: Use of livers from very old donors could expand the donor pool but is not universally implemented. METHODS: This is a retrospective, single-center medical record review. From January 2001 to December 2014, 1354 LTs were performed. After exclusion of donors <18 years, ABO-incompatible LT, re-LT and UNOS 1 status patients, LT recipients were stratified into 2 groups based on donor age: 18-69 (n=692) vs...
May 25, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28548929/brd4-facilitates-dna-damage-response-and-represses-cbx5-heterochromatin-protein-1-hp1
#5
Georgios Pongas, Marianne K Kim, Dong J Min, Carrie D House, Elizabeth Jordan, Natasha Caplen, Sirisha Chakka, Joyce Ohiri, Michael J Kruhlak, Christina M Annunziata
Ovarian cancer (OC) is a heterogeneous disease characterized by defective DNA repair. Very few targets are universally expressed in the high grade serous (HGS) subtype. We previously identified that CHK1 was overexpressed in most of HGSOC. Here, we sought to understand the DNA damage response (DDR) to CHK1 inhibition and increase the anti-tumor activity of this pathway. We found BRD4 suppression either by siRNA or BRD4 inhibitor JQ1 enhanced the cytotoxicity of CHK1 inhibition. Interestingly, BRD4 was amplified and/or upregulated in a subset of HGSOC with statistical correlation to overall survival...
May 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28548675/inducible-bcl-2-gene-rna-interference-mediated-by-aptamer-integrated-hdv-ribozyme-switch
#6
Yuanyuan Zhang, Jine Wang, Hui Cheng, Na Sun, Min Liu, Zhengyan Wu, Renjun Pei
The regulation of RNA interference (RNAi) could be a powerful method for the study of temporal and dose dependent effects of gene expression. In this study, we designed the hepatitis delta virus (HDV) ribozyme with an embedded theophylline aptamer as the sensor domain and the pri-miRNA of endogenous gene Bcl-2 as the effector domain to engineer an RNAi-regulatory device in MCF-7 cells. The system allowed us to control gene expression by adding theophylline into the culture media in a dose dependent fashion...
May 26, 2017: Integrative Biology: Quantitative Biosciences From Nano to Macro
https://www.readbyqxmd.com/read/28548609/a-pilot-study-to-validate-measures-of-the-theory-of-reasoned-action-for-organ-donation-behavior
#7
Shui Hung Wong, Amy Yin Man Chow
The present study aimed at taking the first attempt in validating the measures generated based on the theory of reasoned action (TRA). A total of 211 university students participated in the study, 95 were included in the exploratory factor analysis and 116 were included in the confirmatory factor analysis. The TRA measurements were established with adequate psychometric properties, internal consistency and construct validity. Findings also suggested that attitude towards organ donation has both a cognitive and affective nature, while the subjective norm of the family seems to be important to students' views on organ donation...
May 26, 2017: Death Studies
https://www.readbyqxmd.com/read/28548602/professional-values-and-career-choice-of-nursing-students
#8
Sultan Ayaz Alkaya, Şengül Yaman, Joyce Simones
BACKGROUND AND AIM: Professional values are abstract and general behavioral principles that provide basic standards to judge aims and actions, and these principles are formed by strong emotional loyalty of members of the profession. Research was conducted to compare the career choice and professional values of nursing students at two universities in the upper Midwest of the United States and in the middle of Turkey. MATERIALS AND METHODS: A descriptive and comparative design was used...
January 1, 2017: Nursing Ethics
https://www.readbyqxmd.com/read/28548584/the-sex-disparity-in-risky-driving-a-survey-of-colombian-young-drivers
#9
Oscar Oviedo-Trespalacios, Bridie Scott-Parker
OBJECTIVE: The overrepresentation of young drivers in poor road safety outcomes has long been recognised as a global road safety issue. In addition, the overrepresentation of males in crash statistics has also been recognised as a pervasive young driver problem. Whilst progress in road safety evidenced as a stabilisation and/or reduction in poor road safety outcomes has been made in developed nations, less-developed nations contribute the greatest road safety trauma, and developing nations such as Colombia continue to experience increasing trends in fatality rates...
May 26, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28548517/experimental-determination-of-%C3%AE-s-for-finite-nuclear-matter
#10
Debasish Mondal, Deepak Pandit, S Mukhopadhyay, Surajit Pal, Balaram Dey, Srijit Bhattacharya, A De, Soumik Bhattacharya, S Bhattacharyya, Pratap Roy, K Banerjee, S R Banerjee
We present, for the first time, simultaneous determination of shear viscosity (η) and entropy density (s) and thus, η/s for equilibrated nuclear systems from A∼30 to A∼208 at different temperatures. At finite temperature, η is estimated by utilizing the γ decay of the isovector giant dipole resonance populated via fusion evaporation reaction, while s is evaluated from the nuclear level density parameter (a) and nuclear temperature (T), determined precisely by the simultaneous measurements of the evaporated neutron energy spectra and the compound nuclear angular momenta...
May 12, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28548513/universal-self-similar-scaling-of-spatial-wilson-loops-out-of-equilibrium
#11
J Berges, M Mace, S Schlichting
We investigate strongly correlated non-Abelian plasmas out of equilibrium. Based on numerical simulations, we establish a self-similar scaling property for the time evolution of spatial Wilson loops that characterizes a universal state of matter far from equilibrium. Most remarkably, it exhibits a generalized area law which holds for a sufficiently large ratio of spatial area and fractional power of time. Performing calculations also for the perturbative regime at higher momenta, we are able to characterize the full nonthermal scaling properties of SU(2) and SU(3) symmetric plasmas from short to large distance scales in terms of two independent universal exponents and associated scaling functions...
May 12, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28548512/quantum-fluctuations-along-symmetry-crossover-in-a-kondo-correlated-quantum-dot
#12
Meydi Ferrier, Tomonori Arakawa, Tokuro Hata, Ryo Fujiwara, Raphaëlle Delagrange, Richard Deblock, Yoshimichi Teratani, Rui Sakano, Akira Oguri, Kensuke Kobayashi
Universal properties of entangled many-body states are controlled by their symmetry and quantum fluctuations. By the magnetic-field tuning of the spin-orbital degeneracy in a Kondo-correlated quantum dot, we have modified quantum fluctuations to directly measure their influence on the many-body properties along the crossover from SU(4) to SU(2) symmetry of the ground state. High-sensitive current noise measurements combined with the nonequilibrium Fermi liquid theory clarify that the Kondo resonance and electron correlations are enhanced as the fluctuations, measured by the Wilson ratio, increase along the symmetry crossover...
May 12, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28548477/the-100-most-cited-articles-focused-on-thyroid-research-a-bibliometric-analysis
#13
Eun S Kim, Dae Y Yoon, Ki-Won Oh, Won-Young Lee, Eun-Joo Yun, Young L Seo, Young-Soo Rho
BACKGROUND: The number of citations that an article has received reflects its impact on a particular research area. METHODS: We determined the 100 most-cited articles in thyroid research via the Institute for Scientific Information Web of Knowledge database, using the search term. The following parameters were used to analyze the characteristics of the 100 most-cited articles: publication year, journal (including subject category and impact factor), number of citations and annual citations, authors, department, institution, country, type of study, and topic...
May 26, 2017: Minerva Endocrinologica
https://www.readbyqxmd.com/read/28548350/koenig-and-schultz-s-disaster-medicine-comprehensive-principles-and-practices-2nd-ed-edited-by-kristi-l-koenig-carl-h-schultz-new-york-cambridge-university-press-2016-736-pp-index-205-00-hardcover
#14
REVIEW
Eric C Silverman, Mary P Mercer
No abstract text is available yet for this article.
April 27, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28548239/impact-of-barium-enema-on-acute-diverticulitis-recurrence-a-retrospective-cohort-study-of-349-patients
#15
Francisco J Medina-Fernández, Lidia Rodríguez-Ortiz, Dimas J Garcilazo-Arismendi, Elena Navarro-Rodríguez, Eva M Torres-Tordera, César A Díaz-López, Javier Briceño
AIM: Acute diverticulitis is becoming a health concern in western countries as its incidence is increasing. Currently, one of the accepted theories on possible causes of diverticular perforation is the impactation of faecal residuals into some diverticula. Our aim was to evaluate whether barium impactation might have a negative effect by promoting diverticular inflammation/rupture and thereby acute diverticulitis recurrence. METHODS: A retrospective cohort study (January 2005/December 2015) was conducted at the Reina Sofia University Hospital of Cordoba (Spain)...
May 26, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28548186/-cardiovascular-risk-factors-among-first-and-third-year-university-students
#16
Gladys Morales, Francisco Guillen-Grima, Sergio Muñoz, Carlos Belmar, Ingrid Schifferli, Andrea Muñoz, Alvaro Soto
BACKGROUND: College students are in a critical stage in their life style due to the transition between high school and university and they may be prone to develop cardiovascular diseases. AIM: To compare the prevalence of cardiovascular risk factors (CVRF) in students from first and third year at the University of La Frontera, Temuco-Chile, according to faculty, gender and socioeconomic status (SES). MATERIAL AND METHODS: Cross-sectional study...
March 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/28548095/metabolic-engineering-of-saccharomyces-cerevisiae-for-production-of-very-long-chain-fatty-acid-derived-chemicals
#17
Tao Yu, Yongjin J Zhou, Leonie Wenning, Quanli Liu, Anastasia Krivoruchko, Verena Siewers, Jens Nielsen, Florian David
Production of chemicals and biofuels through microbial fermentation is an economical and sustainable alternative for traditional chemical synthesis. Here we present the construction of a Saccharomyces cerevisiae platform strain for high-level production of very-long-chain fatty acid (VLCFA)-derived chemicals. Through rewiring the native fatty acid elongation system and implementing a heterologous Mycobacteria FAS I system, we establish an increased biosynthesis of VLCFAs in S. cerevisiae. VLCFAs can be selectively modified towards the fatty alcohol docosanol (C22H46O) by expressing a specific fatty acid reductase...
May 26, 2017: Nature Communications
https://www.readbyqxmd.com/read/28548078/associated-variables-of-myositis-in-systemic-lupus-erythematosus-a-cross-sectional-study
#18
Yan Liang, Rui-Xue Leng, Hai-Feng Pan, Dong-Qing Ye
BACKGROUND This study aimed to estimate the point prevalence of myositis and identify associated variables of myositis in systemic lupus erythematosus (SLE). MATERIAL AND METHODS Clinical date of patients hospitalized with lupus at the First Affiliated Hospital of Anhui Medical University and Anhui Provincial Hospital were collected. Patients were defined as having myositis if they reported the presence of persistent invalidating muscular weakness combined with increased levels of creatine phosphokinase (CPK) and abnormal electromyography (EMG)...
May 26, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28547975/clinicopathologic-characteristics-and-resection-rates-of-papillary-early-gastric-cancer-removed-by-endoscopic-submucosal-dissection
#19
Katarzyna Karpińska-Kaczmarczyk, Magdalena Lewandowska, Andrzej Białek, Małgorzata Ławniczak, Ewa Dobak, Elżbieta Urasińska
The aim of this study was to assess the: 1) clinicopathologic features of papillary early gastric cancer (PEGC) (13 cases) compared to tubular early gastric cancer (TEGC) (41 cases); 2) efficiency of endoscopic submucosal dissection (ESD) in treatment of PEGC. From January 2007 to February 2016, a total of 54 consecutive patients with early gastric cancer (EGC) underwent ESD at the Department of Gastroenterology of the Pomeranian Medical University in Poland. The histologic type of carcinoma was assessed according to the WHO histological classification of GC...
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/28547919/the-role-of-friendship-reciprocity-in-university-freshmen-s-alcohol-consumption
#20
Helge Giese, F Marijn Stok, Britta Renner
BACKGROUND: The similarity of friends in the frequency and quantity of alcohol consumption is explored. METHOD: During their first semester, 57 psychology freshmen indicated weekly drinking frequency and quantity and nominated the three peers of this group they liked most. These nominations were then used to derive the weekly alcohol consumption of friends that either did or did not reciprocate a nomination. RESULTS: Multilevel modeling of weekly variations showed that individuals' drinking frequency was similar to peers who reciprocated a friendship (b = 0...
May 26, 2017: Applied Psychology. Health and Well-being
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