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https://www.readbyqxmd.com/read/28239964/training-in-metabolomics-research-ii-processing-and-statistical-analysis-of-metabolomics-data-metabolite-identification-pathway-analysis-applications-of-metabolomics-and-its-future
#1
S Barnes, H P Benton, K Casazza, S J Cooper, X Cui, X Du, J Engler, J H Kabarowski, S Li, W Pathmasiri, J K Prasain, M B Renfrow, H K Tiwari
Metabolomics is perhaps the most challenging of the -omics fields, given the complexity of an organism's metabolome and the rapid rate at which it changes. When one sets out to study metabolism there are numerous dynamic variables that can influence metabolism that must be considered. Recognizing the experimental challenges confronting researchers who undertake metabolism studies, workshops like the one at University of Alabama at Birmingham have been established to offer instructional guidance. A summary of the UAB course training materials is being published as a two-part Special Feature Tutorial...
August 2016: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28239917/decrease-in-mortality-of-adult-epilepsy-patients-since-1980-lessons-learned-from-a-hospital-based-cohort
#2
C A Granbichler, W Oberaigner, G Kuchukhidze, J-P Ndayisaba, A Ndayisaba, A Taylor, G Bauer, G Luef, E Trinka
BACKGROUND AND PURPOSE: Data on mortality in patients with epilepsy have been available since the 1800s. They consistently show a 2-3-fold increase compared to the general population. Despite major advances in diagnostic tools and treatment options, there is no evidence for a decrease in premature deaths. The temporal trend of mortality in a hospital-based epilepsy cohort over three decades was assessed. METHODS: A hospital-based incidence cohort was recruited from a specialized epilepsy outpatient clinic at Innsbruck Medical University between 1980 and 2007, divided by decade into three cohorts and followed for 5 years after initial epilepsy diagnosis...
February 27, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28239910/adverse-symptoms-of-immunosuppressants-a-survey-of-canadian-transplant-clinicians
#3
J J Harrison, H Mansell, T Blydt-Hansen
Adverse symptoms of immunosuppressants (ASI) impact quality of life (QOL) in solid organ transplant recipients, however standardized approaches for active ASI surveillance and intervention are lacking. While management is highly clinician-dependent, clinician views remain largely unexplored. We surveyed Canadian Society of Transplantation members on their perceptions of ASI including frequency, perceived QOL impact, causal attribution, management strategies and success. Sixty-one clinicians participated in the survey of 12 ASI (tremor, diarrhea, nausea, constipation, dyspnea, insomnia, edema, dyspnea, arthralgia, acne, mouth sores, paresthesias), for a 22% response rate...
February 26, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28239634/dataset-for-an-analysis-of-communicative-aspects-of-finance
#4
Natalya Zavyalova
The article describes a step-by-step strategy for designing a universal comprehensive vision of a vast majority of financial research topics. The strategy is focused around the analysis of the retrieval results of the word processing system Serelex which is based on the semantic similarity measure. While designing a research topic, scientists usually employ their individual background. They rely in most cases on their individual assumptions and hypotheses. The strategy, introduced in the article, highlights the method of identifying components of semantic maps which can lead to a better coverage of any scientific topic under analysis...
April 2017: Data in Brief
https://www.readbyqxmd.com/read/28239590/socio-demographic-correlates-of-rhinosporidiosis-a-hospital-based-epidemiologic-study-in-purulia-india
#5
Sirshak Dutta, Dibakar Haldar, Mainak Dutta, Sabyasachi Barik, Kaustuv Das Biswas, Ramanuj Sinha
The present paper attempts to explore the socio-demographic profile of patients with rhinosporidiosis in an endemic area. A cross-sectional study was carried out in a tertiary-care hospital in Purulia district, India, including consecutive patients with histologically-proved rhinosporidiosis. Their socio-demographic profiles were obtained through a pre-designed proforma with given epidemiologic parameters. Data was statistically analyzed with inputs from literature review. Of the 39 patients included, 87 % were fresh/new cases...
March 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/28239553/on-the-use-of-an-optoacoustic-and-laser-ultrasonic-imaging-system-for-assessing-peripheral-intravenous-access
#6
A S Bychkov, V P Zarubin, A A Karabutov, V A Simonova, E B Cherepetskaya
We describe a universal system for research in combined real-time optoacoustic (OA) and laser-ultrasonic (LU) imaging. The results of its testing on the task of needle insertion into the blood vessel model diagnostics are presented. In OA mode, where laser light is absorbed directly in the sample, the contents of blood vessel model is clearly visible. In LU mode, where the short ultrasonic probe pulse scattered on the sample is detected, the needle is clearly visible. The developed solution combining OA and LU imaging modalities due to the common detection system allowed real-time diagnostics of the position of medical needles (0...
March 2017: Photoacoustics
https://www.readbyqxmd.com/read/28239453/the-sink-as-a-potential-source-of-transmission-of-carbapenemase-producing-enterobacteriaceae-in-the-intensive-care-unit
#7
Deborah De Geyter, Lieve Blommaert, Nicole Verbraeken, Mark Sevenois, Luc Huyghens, Helena Martini, Lieve Covens, Denis Piérard, Ingrid Wybo
BACKGROUND: Carbapenemase-producing Enterobacteriaceae (CPE) are emerging pathogens that represent a major public health threat. In the University Hospital of Brussels, the incidence of new patients with CPE rose from 1 case in 2010 to 35 cases in 2015. Between January and August 2015, five patients became infected/colonized with CPE during their stay in the same room in the intensive care unit (ICU). Since the time period between those patients was relatively short and the strains belonged to different species with different antibiograms and mechanisms of resistance, the hypothesis was that the environment could be a possible source of transmission...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/28239447/yeast-help-identify-cytopathic-factors-of-zika-virus
#8
Michael Bukrinsky
Accumulating evidence implicates Zika virus (ZIKV) in pathogenesis of microcephaly in newborns and Guillain-Barré syndrome in adults. However, it remains unclear which viral proteins are responsible for these effects and what are the underlying mechanisms of their pathogenic activity. A recent paper by Drs. Zhao and Gallo, and their colleagues at University of Maryland in Baltimore used fission yeast for genome-wide analysis of ZIKV proteins. They demonstrated cytopathogenic activity for seven ZIKV proteins, anaC, C, prM, M, E, NS2B and NS4A...
2017: Cell & Bioscience
https://www.readbyqxmd.com/read/28239371/loop-mediated-isothermal-amplification-label-based-gold-nanoparticles-lateral-flow-biosensor-for-detection-of-enterococcus-faecalis-and-staphylococcus-aureus
#9
Yi Wang, Hui Li, Yan Wang, Lu Zhang, Jianguo Xu, Changyun Ye
The report describes a simple, rapid and sensitive assay for visual and multiplex detection of Enterococcus faecalis and Staphylococcus aureus based on multiple loop-mediated isothermal amplification (mLAMP) and lateral flow biosensor (LFB). Detection and differentiation of the Ef0027 gene (E. faecalis-specific gene) and nuc gene (S. aureus-specific gene) were determined using fluorescein (FITC)-and digoxin-modified primers in the mLAMP process. In the presence of biotin- and FITC-/digoxin-modified primers, the mLAMP yielded numerous biotin- and FITC-/digoxin-attached duplex products, which were detected by LFB through biotin/streptavidin interaction (biotin on the duplex and streptavidin on the gold nanoparticle) and immunoreactions (FITC/digoxin on the duplex and anti-FITC/digoxin on the LFB test line)...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28239363/formal-and-informal-learning-and-first-year-psychology-students-development-of-scientific-thinking-a-two-wave-panel-study
#10
Demet Soyyılmaz, Laura M Griffin, Miguel H Martín, Šimon Kucharský, Ekaterina D Peycheva, Nina Vaupotič, Peter A Edelsbrunner
Scientific thinking is a predicate for scientific inquiry, and thus important to develop early in psychology students as potential future researchers. The present research is aimed at fathoming the contributions of formal and informal learning experiences to psychology students' development of scientific thinking during their 1st-year of study. We hypothesize that informal experiences are relevant beyond formal experiences. First-year psychology student cohorts from various European countries will be assessed at the beginning and again at the end of the second semester...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28239329/universal-electronic-cigarette-test-physiochemical-characterization-of-reference-e-liquid
#11
Jeffrey J Kim, Nicole Sabatelli, Wojtek Tutak, Anthony Giuseppetti, Stanislav Frukhtbeyn, Ian Shaffer, Joshua Wilhide, Denis Routkevitch, John M Ondov
BACKGROUND: Despite the rising health and safety concerns of e-cigarettes, a universal e-cigarette testing method is still in its early developmental stage. The aim of this study was to develop an e-liquid Reference Material that can be used to improve accuracy and reproducibility of research results, and advance health risk assessment of e-cigarette products. METHODS: E-liquid Reference Material was developed by purity assessment, gravimetric measurement, homogeneity testing, and stability testing with material and instrument traceability (adopted from ISO 35:2006E)...
2017: Tobacco Induced Diseases
https://www.readbyqxmd.com/read/28239324/capsule-retention-caused-by-duodenal-metastases-from-primary-appendiceal-adenocarcinoma
#12
Jen-Wei Chou, Ken-Sheng Cheng
Metastatic small bowel cancers are extremely rare in clinical practice. Primary appendiceal adenocarcinoma with gastrointestinal metastasis is seldom reported in the literature. Here, we describe the case of an 80-year-old male patient with primary appendiceal adenocarcinoma, who presented to China Medical University Hospital with mid-gastrointestinal tract bleeding. Capsule endoscopy revealed stenotic bowel lumen, but the capsule was retained in the distal duodenum. Double-balloon enteroscopy demonstrated erosive and erythematous mucosa in the region of capsule retention...
January 2017: Intestinal Research
https://www.readbyqxmd.com/read/28239318/maternal-and-fetal-outcomes-in-pregnant-japanese-women-with-inflammatory-bowel-disease-our-experience-with-a-series-of-23-cases
#13
Naoki Minami, Minoru Matsuura, Yorimitsu Koshikawa, Satoshi Yamada, Yusuke Honzawa, Shuji Yamamoto, Hiroshi Nakase
BACKGROUND/AIMS: Our physicians work to expand the possibilities to treat female patients with inflammatory bowel disease (IBD) who wish to become pregnant. Although many drugs, including 5-aminosalicylate (5-ASA), corticosteroids, immunomodulators, and biologics, are used safely during pregnancy, few reports have described the therapeutic regimen throughout pregnancy and the management of patients who relapse during pregnancy precisely. The aim of this study was to assess the management of patients with IBD during pregnancy...
January 2017: Intestinal Research
https://www.readbyqxmd.com/read/28239315/single-fecal-microbiota-transplantation-failed-to-change-intestinal-microbiota-and-had-limited-effectiveness-against-ulcerative-colitis-in-japanese-patients
#14
Shinta Mizuno, Kosaku Nanki, Katsuyoshi Matsuoka, Keiichiro Saigusa, Keiko Ono, Mari Arai, Shinya Sugimoto, Hiroki Kiyohara, Moeko Nakashima, Kozue Takeshita, Makoto Naganuma, Wataru Suda, Masahira Hattori, Takanori Kanai
BACKGROUND/AIMS: Recent developments in analytical techniques including next-generation sequencing have clarified the correlation between intestinal microbiota and inflammatory bowel disease. Fecal microbiota transplantation (FMT) for patients with ulcerative colitis (UC) is proposed as a potential approach to resolving their dysbiosis; however, its safety and efficacy have not been confirmed. This single-arm, open-label, non-randomized study aimed to evaluate the safety and efficacy of FMT for Japanese patients with UC as the first registered clinical trial in Japan...
January 2017: Intestinal Research
https://www.readbyqxmd.com/read/28239219/higher-quality-and-lower-cost-from-improving-hospital-discharge-decision-making
#15
James C Cox, Vjollca Sadiraj, Kurt E Schnier, John F Sweeney
This paper reports research on improving decisions about hospital discharges - decisions that are now made by physicians based on mainly subjective evaluations of patients' discharge status. We report an experiment on uptake of our clinical decision support software (CDSS) which presents physicians with evidence-based discharge criteria that can be effectively utilized at the point of care where the discharge decision is made. One experimental treatment we report prompts physician attentiveness to the CDSS by replacing the default option of universal "opt in" to patient discharge with the alternative default option of "opt out" from the CDSS recommendations to discharge or not to discharge the patient on each day of hospital stay...
November 2016: Journal of Economic Behavior & Organization
https://www.readbyqxmd.com/read/28239181/high-dietary-magnesium-intake-is-significantly-and-independently-associated-with-higher-insulin-sensitivity-in-a-mexican-mestizo-population-a-brief-cross-sectional-report
#16
Carlos Moctezuma-Velázquez, Miguel Ángel Gómez-Sámano, María Belén Cajas-Sánchez, Diana Lorena Reyes-Molina, Mariana Galindo-Guzmán, Clara-Elena Meza-Arana, Daniel Cuevas-Ramos, Francisco Javier Gómez-Pérez, Alfonso Gulias-Herrero
BACKGROUND: Magnesium acts as a cofactor in many intracellular reactions including phosphorylation of the insulin receptor; therefore, its imbalance can potentially cause insulin resistance. Low serum magnesium concentration has been associated with the development of metabolic syndrome and type 2 diabetes mellitus. OBJECTIVE: To study the association between the daily dietary magnesium intake and insulin resistance estimated by the homeostatic model assessment of insulin resistance and homeostatic model assessment 2, as well as insulin sensitivity estimated by the Matsuda index...
January 2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/28239079/rifabutin-based-fourth-and-fifth-line-rescue-therapy-in-patients-with-for-helicobacter-pylori-eradication-failure
#17
Jihee Sung, Nayoung Kim, Yo Han Park, Young Jae Hwang, Soohoon Kwon, Gyeongjae Na, Joon Young Choi, Jae Bin Kang, Hye Rang Kim, Jin Wook Kim, Dong Ho Lee
Background/Aims: Optimized regimen has not yet been established for failures of multiple Helicobacter pylori (H. pylori) eradication. Hence, we aimed to evaluate the efficacy of rifabutin-based rescue therapy, at least after three eradication failures. Methods: Twelve patients, who failed in the treatment for H. pylori eradication at least three times, were consecutively enrolled between 2007 and 2015 at Seoul National University Bundang Hospital. The rifabutin-based rescue regimen was consisted of proton pump inhibitor (PPI), rifabutin (150 mg b...
February 25, 2017: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/28239024/in-practical-training-a-questionnaire-survey-and-analysis-to-pharmacy-students-of-the-utilization-situation-of-the-course-contents-of-pharmacy-school
#18
Masato Okubo, Yuka Takahashi, Jun Yamashita, Hideyo Takahashi, Okiko Miyata, Takaaki Suzuki, Itsuko Ishii
  Pharmacy education comprises basic pharmacy (organic chemistry, biochemistry, and physical chemistry) and applied pharmacy (clinical pharmacy, pharm aceutics, and chemical hygiene). Students are expected to apply these subjects studied in pharmacy school during their practical pharmacy training. However, knowledge gained in university does not appear to be fully utilized in practice. We hypothesized that this is due to a lack of connection between pre-practical training education and actual practical training...
February 24, 2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/28239012/neighborhood-trauma-due-to-violence-a-multilevel-analysis
#19
Sandra D Lane, Robert A Rubinstein, Dessa Bergen-Cico, Timothy Jennings-Bey, Linda Stone Fish, David A Larsen, Mindy Thompson Fullilove, Tracey Reichert Schimpff, Kishi Animashaun Ducre, Jonnell Allen Robinson
In Syracuse, New York the social determinants of trauma from neighborhood violence are rooted in historical processes, including urban renewal, the Rockefeller drug laws, and de-industrialization. These contributed to destabilizing Syracuse communities of color, resulting in disproportionate incarceration, family disruption, and economic devastation. Community violence, clustering in densely populated neighborhoods, creates unmanageable stress for the families who live in them. A map of gunshots and gun fatalities (2009 to 2014) illustrates the continuing onslaught of bullets being fired, often in close proximity to elementary schools...
2017: Journal of Health Care for the Poor and Underserved
https://www.readbyqxmd.com/read/28239001/the-role-of-historically-black-college-and-university-medical-schools-in-academic-medicine
#20
José E Rodríguez, Ivette A López, Kendall M Campbell, Matthew Dutton
INTRODUCTION: Although less than 3% of medical schools are considered Historically Black Colleges and Universities (HBCU), they have played a significant role in the education of Black physicians. METHODS: The Association of American Medical Colleges (AAMC) databases were used to obtain faculty and student demographic data from 2003-2013. We analyzed racial distributions of faculty and students at HBCU medical schools compared with all other medical schools and calculated correlations between rates of Black chairs, faculty, and students...
2017: Journal of Health Care for the Poor and Underserved
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