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Susan S Li, Don Hayes, Joseph D Tobias, Wayne J Morgan, Dmitry Tumin
BACKGROUND: Low socioeconomic status is correlated with worse outcomes in patients with cystic fibrosis. Whether insurance status impacts adherence to care in this population is unknown. METHODS: Patients ≥18 years old in the CF Foundation Patient Registry (2005-2013) were grouped based on reported annual insurance as private, public (Medicaid, Medicare, or state medical assistance program), other, or no insurance. Random effects logistic regression evaluated association between change in insurance status and annual use of recommended routine care...
January 22, 2018: Clinical Respiratory Journal
Songyuan Tao, Siyu Lu, Yijia Geng, Shoujun Zhu, Simon Redfern, Yubin Song, Tanglue Feng, Weiqing Xu, Bai Yang
Polymer carbon dots (PCDs) are proposed as a new class of room temperature phosphorescence (RTP) materials. The abundant energy levels in PCDs increase the probability of intersystem crossing (ISC) and their covalently-crosslinked framework structures greatly suppress the non-radiative transitions. The efficient methods allow the manufacture of PCDs with unique RTP properties in air without the need for additional metal complexing or for the adopting of complicated matrix compositing. They thus provide a route towards the rational design of metal-free RTP materials that may be synthesized easily...
January 22, 2018: Angewandte Chemie
Jie Wang, Yunling Xu, Bing Ding, Zhi Chang, Xiaogang Zhang, Yusuke Yamauchi, Kevin Chia-Wen Wu
Although two-dimensional (2D) carbon materials are widely investigated, a well-defined 2D carbon nanosheet with an ordered mesostructure has rarely been realized. Herein monolayer ordered mesoporous carbon nanosheets (OMCNS) are prepared through confinement assembly of resol and F127 in the interlayer of montmorillonite (MONT). The nano-distances of the interlayer space of MONT only allow the assembly of resol and F127 in the same plane, leading to ordered mesopores perpendicular to carbon nanosheets, and favour the formation of sp2 carbon, resulting in highly graphitization degree...
January 22, 2018: Angewandte Chemie
Valentine Baert, Joséphine Escutnaire, Ziad Nehme, Pierre Mols, Steven Lagadec, Christian Vilhelm, Line Jacob, Eric Wiel, Frédéric Adnet, Hervé Hubert
RATIONALE, AIMS AND OBJECTIVES: Care quality is a primary concern in health field. In France, the care practice report card (CPRC) is compulsory for practitioners. It is the first step towards the culture of excellence. In this context, practitioners have to assess and improve their practices. Competent authorities define registries as reliable sources for CPRC. The first aim of this work is to describe how we designed and built a universally transposable CPRC model based on an Utstein-style cardiac arrest registry...
January 22, 2018: Journal of Evaluation in Clinical Practice
Rongrong Bian, Yuqun Zhang, Yuan Yang, Yingying Yin, Xiaoxin Zhao, Huanxin Chen, Yonggui Yuan
BACKGROUND: Cognitive impairments are common in asthma, which is a serious global health problem characterized by chronic airway inflammation. However, the underlying neuromechanism is still unclear. PURPOSE/HYPOTHESIS: To investigate the neuromechanism underlying cognitive impairments of asthma. We hypothesized that asthma patients exhibit altered white matter (WM) microstructures, which may contribute to their cognitive impairments. STUDY TYPE: Case-control study...
January 21, 2018: Journal of Magnetic Resonance Imaging: JMRI
Shufeng Liu, Yishen Tian, Shanshan Zhang, Li Wang
A new modular nanoswitch was described for versatile, rapid (within 1 h), homogeneous and sensitive protein detection. The system employs two hairpins (HP1 and HP2) that can be reciprocally recognized through the apical loop-loop interaction. The HP2 possesses a conformation-switching stem-loop structure with the appended single-stranded tails on each end, which can hybridize with the recognition element-conjugated DNA strands to construct a protein-responsive HP2 scaffold. It works according to a simple mix-and-detect assay format with the first formation of a kissing complex between HP1 and HP2 scaffold for fluorescence quenching and then the cascade propagation from the steric strain by protein binding to the dissociation of kissing complex for fluorescence recovery...
January 22, 2018: Chembiochem: a European Journal of Chemical Biology
Kenneth Hugdahl
In this article I have summarized some of the main trends and topics of my research career, spanning a time period of 50 years, from its start as a master student at the Department of Psychology, University of Uppsala, Sweden to seeing the end of a long career, now at the University of Bergen, Norway. This journey has, apart from having been a journey across various disciplines and topics in experimental psychology, psychophysiology and neuropsychology, functional neuroimaging and cognitive neuroscience, also been a social class journey for me personally...
February 2018: Scandinavian Journal of Psychology
Sayna Matinrazm, Adetola Ladejobi, Deepak Kumar Pasupula, Awais Javed, Asad Durrani, Shahzad Ahmad, Muhammad Bilal Munir, Evan Adelstein, Sandeep K Jain, Samir Saba
BACKGROUND: Although elevated body mass index (BMI) is a risk factor for cardiac disease, patients with elevated BMI have better survival in the context of severe illness, a phenomenon termed the "obesity paradox." HYPOTHESIS: Higher BMI is associated with lower mortality in sudden cardiac arrest (SCA) survivors. METHODS: Data were collected on 1433 post-SCA patients, discharged alive from the hospitals of the University of Pittsburgh Medical Center between 2002 and 2012...
January 22, 2018: Clinical Cardiology
Florencio Quero-Valenzuela, Inmaculada Piedra-Fernández, María Martínez-Ceres, Pedro J Romero-Palacios, Abel Sánchez-Palencia, Antonio Cueto-Ladrón De Guevara, Pablo Torné-Poyatos
BACKGROUND: The purpose of this study was to assess the rate, cause, and factors associated with readmissions following pulmonary resection for lung cancer and their relationship with 90-day mortality. METHODS: A prospective cohort study was conducted of 379 patients who underwent surgery for lung cancer at the university hospitals Granada, Spain between 2012 and 2016. RESULTS: The rate of readmissions within 30 postoperative days was 6.2%...
January 22, 2018: Journal of Surgical Oncology
Katherine L Possin, Tacie Moskowitz, Sabrina J Erlhoff, Kirsten M Rogers, Erica T Johnson, Natasha Z R Steele, Joseph J Higgins, Jordan Stiver, Andrea G Alioto, Sarah T Farias, Bruce L Miller, Katherine P Rankin
BACKGROUND/OBJECTIVES: Brief cognitive screens lack the sensitivity to detect mild cognitive impairment (MCI) or support differential diagnoses. The objective of this study was to validate the 10-minute, tablet-based University of California, San Francisco (UCSF) Brain Health Assessment (BHA) to overcome these limitations. DESIGN: Cross-sectional. SETTING: UCSF Memory and Aging Center. PARTICIPANTS: Older adults (N = 347) (neurologically healthy controls (n = 185), and individuals diagnosed with MCI (n = 99), dementia (n = 42), and as normal with concerns (n = 21))...
January 2018: Journal of the American Geriatrics Society
Celin Arce, Nathaniel C Lawson, Perng-Ru Liu, Chee Paul Lin, Daniel A Givan
PURPOSE: Screw-retained zirconia implant crowns with an internal titanium base have favorable mechanical properties compared with single-piece zirconia implant crowns; however, the screw-retained implant crowns require adequate bonding between the zirconia crown and the titanium base. This study measured the retention between a titanium base and a full-contour zirconia implant crown following different surface treatments of their bonded surfaces. MATERIALS AND METHODS: Full-contour screw-retained zirconia implant crowns were fabricated to fit a titanium base...
January 19, 2018: International Journal of Oral & Maxillofacial Implants
Elijah Bisung, Susan J Elliott
This study uses a cross-sectional survey (n = 557) with a retrospective design to examine relationships between improvement in access to safe water supply (i.e. extension of municipal piped water) and a range of social outcomes including water insecurity, household time savings and allocation, and household water expenditure in Usoma, Kenya. Data were collected in July 2016, about 3 years after the intervention, using a modified version of the Household Water Insecurity Access Scale (HWIAS). Having assessed the validity and reliability of the modified HWIAS, we examine how differences in levels of access to safe water influence reported levels of water insecurity as well as amount of money and time savings, post the water intervention...
January 3, 2018: Social Science & Medicine
Eline Eberhardt, Magali Van den Kerkhof, Dimitri Bulté, Dorien Mabille, Lieselotte Van Bockstal, Séverine Monnerat, Fabiana Alves, Jane Mbui, Peter Delputte, Paul Cos, Sarah Hendrickx, Louis Maes, Guy Caljon
Several methods have been developed for the detection of Leishmania, mostly targeting the minicircle kinetoplast DNA (kDNA). A new RNA qPCR assay was developed targeting the conserved and highly expressed spliced-leader (SL) mini-exon sequence. This study compared the limits of detection of various real-time PCR assays in hamsters infected with Leishmania infantum, in spiked human blood and in clinical blood samples from visceral leishmaniasis patients. The SL-RNA assay showed an excellent analytical sensitivity in tissues (0...
January 17, 2018: Journal of Molecular Diagnostics: JMD
Woo-Seok Bang, Dong-Hyun Lee, Kyoung-Tae Kim, Dae-Chul Cho, Joo-Kyung Sung, In-Bo Han, Du-Hwan Kim, Brian K Kwon, Chi Heon Kim, Ki-Su Park, Man-Kyu Park, Sung-Young Seo, Ye-Jin Seo
BACKGROUND CONTEXT: Vitamin D deficiency (VDD) has been closely linked with skeletal muscle atrophy in many studies, but to date no study has focused on paraspinal muscle. PURPOSE: To verify paraspinal muscle changes according to serum vitamin D level. STUDY DESIGN: A cross-sectional study of patients who visited our hospital and an in vivo animal study METHODS: We measured serum vitamin D concentration in 91 elderly women and stratified them according to their vitamin D status in three groups: control, vitamin D insufficiency, and VDD, and obtained magnetic resonance imaging data of the lumbar spine and evaluated the quality and quantity of the paraspinal muscles...
January 16, 2018: Spine Journal: Official Journal of the North American Spine Society
Ricardo Durães-Carvalho, Marco Salemi
This study applied High-Performance Computing to explore the high-resolution phylodynamics and the evolutionary dynamics of Influenza viruses (IVs) A and B and their subtypes in-depth to identify peptide-based candidates for broad-spectrum vaccine targets. For this purpose, we collected all the available Hemagglutinin (HA) and Neuraminidase (NA) nucleotide and amino acid sequences (more than 100,000) of IVs isolated from all the reservoirs and intermediate hosts species, from all geographic ranges and from different isolation sources, covering a period of almost one century of sampling years...
January 17, 2018: Molecular Phylogenetics and Evolution
Yusuke Sato'o, Yoshifumi Aiba, Kotaro Kiga, Shinya Watanabe, Teppei Sasahara, Yasuhiko Hayakawa, Longzhu Cui
Electroporation is a common technique necessary for genomic manipulation of Staphylococci. However, because this technique has too low efficiency to be applied to some Staphylococcal species and strains, especially to coagulase-negative Staphylococcus (CNS) isolates, basic researches on these clinically important Staphylococci is limited. Here we report on the optimization of electroporation parameters and conditions as well as on the generation of a universal protocol that can be efficiently applicable to both CNS and Coagulase-positive Staphylococci (CPS)...
January 17, 2018: Journal of Microbiological Methods
S Ghazala, J Bilal, E Ross, B Kalb, I B Riaz, K L Herbst
BACKGROUND/AIM: Dercum disease is a rare disorder of painful subcutaneous adipose tissue masses typically presenting as a constellation of signs and symptoms affecting most organs including slow lymphatic flow and fatty liver. METHOD: The University of Arizona Institutional Review Board considered this report exempt after patient consent. Multislice, multisequence magnetic resonance imaging (MRI) of the abdomen and pelvis was performed before and after d-amphetamine, with and without intravenous gadolinium...
January 17, 2018: American Journal of Medicine
Todd A Astorino, Noelle Bediamol, Sarah Cotoia, Kenneth Ines, Nicolas Koeu, Natasha Menard, Brianna Nyugen, Cassandra Olivo, Gabrielle Phillips, Ardreen Tirados, Gabriela Velasco Cruz
CONTEXT/OBJECTIVE: Maximal oxygen uptake (VO2max) is a widely used measure of cardiorespiratory fitness, aerobic function, and overall health risk. Although VO2max has been measured for almost 100 yr, no standardized criteria exist to verify VO2max attainment. Studies document that incidence of 'true' VO2max obtained from incremental exercise (INC) can be confirmed using a subsequent verification test (VER). In this study, we examined efficacy of VER in persons with spinal cord injury (SCI)...
January 22, 2018: Journal of Spinal Cord Medicine
Michele Schiavon, Chiara Dalla Man, Claudio Cobelli
BACKGROUND AND AIM: The insulin to carbohydrate ratio (CR) is a parameter used by patients with type 1 diabetes (T1D) to calculate the premeal insulin bolus. Usually, it is estimated by the physician based on patient diary, but modern diabetes technologies, such as subcutaneous glucose sensing (continuous glucose monitoring, CGM) and insulin delivery (continuous subcutaneous insulin infusion, CSII) systems, can provide important information for its optimization. In this study, a method for CR optimization based on CGM and CSII data is presented and its efficacy and robustness tested in several in silico scenarios, with the primary aim of increasing protection against hypoglycemia...
February 2018: Diabetes Technology & Therapeutics
Sophie Gregory, Ceri Llewellyn
Teledermatology plays a vital role within Aneurin Bevan University Health Board. Alongside Consultant Dermatologists we developed Teledermatology to meet clinical needs. This article illustrates the implementation process of the service, highlighting legal and ethical issues that were considered along with the success and scope of the service. The Teledermatology service rapidly reduced waiting times for patients and increased access to specialist care which is cost effective for the Health Board. Following successful implementation and increased demand, there is the scope for expansion...
January 22, 2018: Journal of Visual Communication in Medicine
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