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listeria meningitis

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https://www.readbyqxmd.com/read/28156183/listeriolysin-s-a-bacteriocin-from-epidemic-listeria-monocytogenes-strains-that-targets-the-microbiota
#1
Juan-José Quereda-Torres, Jazmín Meza-Torres, Pascale Cossart, Javier Pizarro-Cerdá
Listeria monocytogenes is a Gram-positive food-borne pathogen that in humans may traverse the intestinal, placental and blood/brain barriers, causing gastroenteritis, abortions and meningitis. Crossing of these barriers is dependent on the bacterial ability to enter host cells, and several L. monocytogenes surface and secreted virulence factors are known to facilitate entry and the intracellular lifecycle. The study of L. monocytogenes strains associated to human listeriosis epidemics has revealed the presence of novel virulence factors...
February 3, 2017: Gut Microbes
https://www.readbyqxmd.com/read/28098781/distinct-neurotoxicity-profile-of-listeriolysin-o-from-listeria-monocytogenes
#2
Jana Maurer, Sabrina Hupp, Carolin Bischoff, Christina Foertsch, Timothy J Mitchell, Trinad Chakraborty, Asparouh I Iliev
Cholesterol-dependent cytolysins (CDCs) are protein toxins that originate from Gram-positive bacteria and contribute substantially to their pathogenicity. CDCs bind membrane cholesterol and build prepores and lytic pores. Some effects of the toxins are observed in non-lytic concentrations. Two pathogens, Streptococcus pneumoniae and Listeria monocytogenes, cause fatal bacterial meningitis, and both produce toxins of the CDC family-pneumolysin and listeriolysin O, respectively. It has been demonstrated that pneumolysin produces dendritic varicosities (dendrite swellings) and dendritic spine collapse in the mouse neocortex, followed by synaptic loss and astrocyte cell shape remodeling without elevated cell death...
January 13, 2017: Toxins
https://www.readbyqxmd.com/read/28065808/bacterial-meningitis-in-alcoholic-patients-a-population-based-prospective-study
#3
Kiril E B van Veen, Matthijs C Brouwer, Arie van der Ende, Diederik van de Beek
OBJECTIVES: To study clinical features and outcome of community-acquired bacterial meningitis in alcoholic patients. METHODS: Patients with a history of alcoholism were selected from our nationwide, prospective cohort on community-acquired bacterial meningitis performed from March 2006 to October 2014. Data on patient history, symptoms and signs on admission, treatment, and outcome were prospectively collected. RESULTS: Of 1359 included episodes, 88 episodes (6%) occurred in 88 alcoholic patients...
January 5, 2017: Journal of Infection
https://www.readbyqxmd.com/read/27998823/benzalkonium-tolerance-genes-and-outcome-in-listeria-monocytogenes-meningitis
#4
P H C Kremer, J A Lees, M M Koopmans, B Ferwerda, A W M Arends, M M Feller, K Schipper, M Valls Seron, A van der Ende, M C Brouwer, D van de Beek, S D Bentley
OBJECTIVES: Listeria monocytogenes is a food-borne pathogen that can cause meningitis. The listerial genotype ST6 has been linked to increasing rates of unfavourable outcome over time. We investigated listerial genetic variation and the relation with clinical outcome in meningitis. METHODS: We sequenced 96 isolates from adults with listerial meningitis included in two prospective nationwide cohort studies by whole genome sequencing, and evaluated associations between bacterial genetic variation and clinical outcome...
December 18, 2016: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/27976567/successful-treatment-of-refractory-listeria-meningitis-and-bacteremia-with-trimethoprim-sulfamethoxazole-in-an-immunocompetent-child
#5
Meltem Polat, Soner Sertan Kara, Anıl Tapısız, Okşan Derinöz, Kayhan Çağlar, Hasan Tezer
Listeria monocytogenes is an important cause of life-threatening bacteremia and meningoencephalitis in neonates, pregnant women, the elderly, and immunocompromised individuals. However, it is an uncommon cause of illness in immunocompetent children beyond the neonatal period. Ampicillin with or without an aminoglycoside remains the best treatment for listeriosis. Here, we report a rare case of Listeria meningitis and bacteremia in a 7-month-old immunocompetent girl, which was refractory to ampicillin plus gentamicin treatment and successfully treated by the addition of TMP/SMX...
2016: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/27881637/closing-the-brief-case-neonatal-meningitis-caused-by-listeria-monocytogenes-diagnosed-by-multiplex-molecular-panel
#6
EDITORIAL
Vikram Anand, Jenna Holmen, Michael Neely, Pia S Pannaraj, Jennifer Dien Bard
No abstract text is available yet for this article.
December 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27881634/the-brief-case-neonatal-meningitis-caused-by-listeria-monocytogenes-diagnosed-by-multiplex-molecular-panel
#7
EDITORIAL
Vikram Anand, Jenna Holmen, Michael Neely, Pia S Pannaraj, Jennifer Dien Bard
No abstract text is available yet for this article.
December 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27671041/mitogen-activated-protein-kinases-are-required-for-effective-infection-of-human-choroid-plexus-epithelial-cells-by-listeria-monocytogenes
#8
Stefanie Dinner, Julian Kaltschmidt, Carolin Stump-Guthier, Svetlana Hetjens, Hiroshi Ishikawa, Tobias Tenenbaum, Horst Schroten, Christian Schwerk
Listeria monocytogenes, a Gram-positive bacterium, can cause meningitis after invading the human central nervous system. The blood-cerebrospinal fluid barrier (BCSFB), located at the epithelium of the choroid plexus, is a possible entry site for L. monocytogenes into the brain, and in vitro L. monocytogenes invades human choroid plexus epithelial papilloma (HIBCPP) cells. Although host cell signal transduction subsequent to infection by L. monocytogenes has been investigated, the role of mitogen-activated protein kinases (MAPK) is not clarified yet...
January 2017: Microbes and Infection
https://www.readbyqxmd.com/read/27605478/-a-case-of-hydrocephalus-in-i-listeria-i-meningitis-treated-by-endoscopic-third-ventriculostomy
#9
Takatsugu Abe, Tomohiro Kawaguchi, Miki Fujimura, Teiji Tominaga
A 69-year-old woman presented with anorexia, fever, and vomiting. The patient was not a compromised host. She was finally diagnosed with <i>Listeria</i> meningitis and treated with ampicillin and gentamicin. However, her condition worsened over time. Non-contrast head CT showed ventricular dilatation. As a result, continuous right ventricular drainage was performed. Non-contrast MRI revealed hydrocephalus due to stenosis of the fourth ventricle. She underwent endoscopic third ventriculostomy(ETV)to improve cerebrospinal fluid circulation...
September 2016: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/27600509/extracellular-superoxide-dismutase-enhances-recruitment-of-immature-neutrophils-to-the-liver
#10
Timothy J Break, Alexandra R Witter, Mohanalaxmi Indramohan, Mark E Mummert, Ladislav Dory, Rance E Berg
Listeria monocytogenes is a Gram-positive intracellular pathogen that causes spontaneous abortion in pregnant women, as well as septicemia, meningitis, and gastroenteritis, primarily in immunocompromised individuals. Although L. monocytogenes can usually be effectively treated with antibiotics, there is still around a 25% mortality rate with individuals who develop clinical listeriosis. Neutrophils are innate immune cells required for the clearance of pathogenic organisms, including L. monocytogenes The diverse roles of neutrophils during both infectious and noninfectious inflammation have recently gained much attention...
December 2016: Infection and Immunity
https://www.readbyqxmd.com/read/27600175/pyelonephritis-with-bacteremia-caused-by-listeria-monocytogenes-a-case-report
#11
Shunsuke Uno, Ryota Hase, Akihiro Toguchi, Yoshihito Otsuka, Naoto Hosokawa
Listeria monocytogenes is a well-known cause of meningitis, colitis, and bacteremia; however, obstructive pyelonephritis caused by L. monocytogenes has never been reported. We herein report on a 90-year-old Japanese woman with obstructive pyelonephritis and bacteremia due to uterus carcinoma invading the ureter. She was admitted to our hospital complaining of fever and chills, and her physical examination revealed left costovertebral angle tenderness. Computed tomography showed hydronephrosis and complete ureteral obstruction due to tumor invasion...
February 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/27541039/predictive-risk-factors-for-listeria-monocytogenes-meningitis-compared-to-pneumococcal-meningitis-a-multicenter-case-control-study
#12
Seungjin Lim, Doo Ryeon Chung, Yeon-Sook Kim, Kyung Mok Sohn, Seung-Ji Kang, Sook-In Jung, Shin-Woo Kim, Hyun Ha Chang, Seung Soon Lee, In-Gyu Bae, Chisook Moon, Ji-Young Rhee, Jin Seo Lee, Hyun Kyun Ki, Hyun Ah Kim, Seong Yeol Ryu, Joon-Sup Yeom, Jun Seong Son, Soo-Youn Moon, Ki Tae Kwon, Hyuck Lee, Sang Taek Heo, Cheol-In Kang, Kyong Ran Peck, Jae-Hoon Song
PURPOSE: Various immunocompromised conditions increase the risk of meningitis caused by Listeria monocytogenes. However, the relative importance of these risk factors has not been well established. We determined the risk factors that predict meningitis due to L. monocytogenes compared to that caused by Streptococcus pneumoniae. METHODS: A nationwide multicenter case-control study was conducted in Korea. Cases of meningitis caused by L. monocytogenes between 1998 and 2013 were included...
August 19, 2016: Infection
https://www.readbyqxmd.com/read/27430683/listeria-rhombencephalitis-mimicking-a-demyelinating-event-in-an-immunocompetent-young-patient
#13
Bernhard F Décard, Jan Thöne, Aiden Haghikia, Christian Börnke, Agnes Anders, Carsten Lukas, Ralf Gold
BACKGROUND: Listeriosis caused by listeria monocytogenes (LM) is a potentially lethal foodborne infection of the central nervous system (CNS) and the third most common cause of bacterial meningitis. Foods most commonly implicated are soft cheeses, raw or ready-to-eat meat and pre-processed foods. The incubation time is between 11 and 70 days. Rarely LM rhombencephalitis (RE) can occur, which typically has a biphasic course with non- specific prodromal symptoms like fever, malaise, fatigue, headache, nausea and vomiting followed by cranial nerve palsies, ataxia and hemi- or tetraparesis...
January 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/27385317/bacterial-meningitis-in-solid-organ-transplant-recipients-a-population-based-prospective-study
#14
K E B van Veen, M C Brouwer, A van der Ende, D van de Beek
BACKGROUND: Solid organ transplant (SOT) recipients are at risk of infections of the central nervous system. However, the incidence and clinical course of bacterial meningitis in SOT recipients are unclear. We studied occurrence, disease course, and prognosis of bacterial meningitis in SOT recipients in the Netherlands. METHODS: All patients with a medical history of solid organ transplantation were selected from our nationwide prospective cohort study on community-acquired bacterial meningitis in patients >16 years old, performed from March 1, 2006 to October 31, 2014...
October 2016: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/27367319/listeria-monocytogenes-meningitis-in-the-elderly-epidemiological-clinical-and-therapeutic-findings
#15
Pasquale Pagliano, Tiziana Ascione, Giovanni Boccia, Francesco De Caro, Silvano Esposito
Listeria monocytogenes is a Gram-positive bacillus and facultative intracellular bacterium whose transmission occurs mainly through the consumption of contaminated food, L. monocytogenes invades the host cells using various protein and can escape to the human T-cell immune system by cell-to-cell spreading. If the infection is not controlled at the stage in which the bacterium is in the liver, for instance, due to a severe immunodepression, a secondary bacteraemia can be developed and L. monocytogenes reaches the preferred sites transgressing the blood-brain barrier or the placental barrier...
June 1, 2016: Le Infezioni in Medicina
https://www.readbyqxmd.com/read/27345176/antibiotic-treatment-and-mortality-in-patients-with-listeria-monocytogenes-meningitis-or-bacteraemia
#16
S Thønnings, J D Knudsen, H C Schønheyder, M Søgaard, M Arpi, K O Gradel, C Østergaard
Invasive Listeria monocytogenes infections carry a high mortality despite antibiotic treatment. The rareness of the infection makes it difficult to improve antibiotic treatment through randomized clinical trials. This observational study investigated clinical features and outcome of invasive L. monocytogenes infections including the efficacy of empiric and definitive antibiotic therapies. Demographic, clinical and biochemical findings, antibiotic treatment and 30-day mortality for all episodes of L. monocytogenes bacteraemia and/or meningitis were collected by retrospective medical record review in the North Denmark Region and the Capital Region of Denmark (17 hospitals) from 1997 to 2012...
August 2016: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/27335149/multicenter-evaluation-of-biofire-filmarray-meningitis-encephalitis-panel-for-detection-of-bacteria-viruses-and-yeast-in-cerebrospinal-fluid-specimens
#17
Amy L Leber, Kathy Everhart, Joan-Miquel Balada-Llasat, Jillian Cullison, Judy Daly, Sarah Holt, Paul Lephart, Hossein Salimnia, Paul C Schreckenberger, Sharon DesJarlais, Sharon L Reed, Kimberle C Chapin, Lindsay LeBlanc, J Kristie Johnson, Nicole L Soliven, Karen C Carroll, Jo-Anne Miller, Jennifer Dien Bard, Javier Mestas, Matthew Bankowski, Tori Enomoto, Andrew C Hemmert, Kevin M Bourzac
Rapid diagnosis and treatment of infectious meningitis and encephalitis are critical to minimize morbidity and mortality. Comprehensive testing of cerebrospinal fluid (CSF) often includes Gram stain, culture, antigen detection, and molecular methods, paired with chemical and cellular analyses. These methods may lack sensitivity or specificity, can take several days, and require significant volume for complete analysis. The FilmArray Meningitis/Encephalitis (ME) Panel is a multiplexed in vitro diagnostic test for the simultaneous, rapid (∼1-h) detection of 14 pathogens directly from CSF specimens: Escherichia coli K1, Haemophilus influenzae, Listeria monocytogenes, Neisseria meningitidis, Streptococcus pneumoniae, Streptococcus agalactiae, cytomegalovirus, enterovirus, herpes simplex virus 1 and 2, human herpesvirus 6, human parechovirus, varicella-zoster virus, and Cryptococcus neoformans/Cryptococcus gattii We describe a multicenter evaluation of 1,560 prospectively collected CSF specimens with performance compared to culture (bacterial analytes) and PCR (all other analytes)...
September 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27249907/listeriosis-is-it-a-rare-disease-in-thailand
#18
Weerasak Lawtongkum, Usa Thisyakorn
The prevalence of Listeria monocytogenes infection has been characterized as rare in Thailand. Within one month, 3 cases of listeriosis were seen at Vachira Phuket Hospital in Phuket, Thailand. Two cases were neonates with septicemia, of which one made an uneventful recovery and the other expired. The third case was an eleven-year-old boy with meningitis who also succumbed to his illness. All isolated L. monocytogenes were sensitive to ampicillin. An outbreak investigation revealed no L. monocytogenes contamination in tested food sources in Phuket...
February 2016: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
https://www.readbyqxmd.com/read/27170703/a-rare-case-of-listeriosis-acute-cholecystitis-and-multiple-myeloma
#19
Thais O Polanco, Sara Alothman, Hector Depaz, Alexius Ramcharan
Listeria monocytogenes (LM) is an aerobic, motile, intracellular gram-positive bacterium. Most invasive systemic infections caused by LM are commonly seen in patients at both extremes of age, during pregnancy or in immunocompromised hosts. Common clinical manifestations of LM infection in immunocompromised adults are bacteremia, infections of central nervous system, such as meningitis, and self-limiting febrile gastroenteritis. Focal infections of listeria are rare, especially cholecystitis, with only few cases reported in the last 33 years...
2016: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/27104604/listeriosis-and-toxoplasmosis-in-pregnancy-essentials-for-healthcare-providers
#20
Nicole Franzen Pfaff, Jackie Tillett
Listeriosis and toxoplasmosis are foodborne illnesses that can have long-term consequences when contracted during pregnancy. Listeriosis is implicated in stillbirth, preterm labor, newborn sepsis, and meningitis, among other complications. Toxoplasmosis is associated with blindness, cognitive delays, seizures, and hearing loss, among other significant disabilities. Healthcare providers who understand the fundamentals of Listeria and Toxoplasma infection will have the tools to identify symptoms and high-risk behaviors, educate women to make safer decisions, and provide anticipatory guidance if a pregnant woman would become infected with either of these foodborne illnesses...
April 2016: Journal of Perinatal & Neonatal Nursing
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