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https://www.readbyqxmd.com/read/28944115/demographics-and-incidence-of-histologically-confirmed-intracranial-tumors-a-five-year-two-center-prospective-study
#1
George S Stoyanov, Deyan L Dzhenkov, Martina Kitanova, Peter Ghenev, Anton B Tonchev
Introduction Intracranial tumors (ICTs) are a diverse group of malignancies that pose an immediate threat to patients' lives, no matter their local or metastatic origin, benign or malignant nature. These lesions have severe clinical courses and need to be diagnosed and treated as soon as possible, with pathological verification being the pivotal moment in the process of determining curative modalities. Aim The aim of this study was to compare the incidence of histologically confirmed ICTs in Eastern Bulgaria, based on their type (primary, metastatic, and non-volume occupying lesions (NVOL)), their respective subtypes, and incidence in a descriptive manner...
July 16, 2017: Curēus
https://www.readbyqxmd.com/read/28929046/application-of-three-dimensional-printing-for-colon-targeted-drug-delivery-systems
#2
REVIEW
Nitin B Charbe, Paul A McCarron, Majella E Lane, Murtaza M Tambuwala
Orally administered solid dosage forms currently dominate over all other dosage forms and routes of administrations. However, human gastrointestinal tract (GIT) poses a number of obstacles to delivery of the drugs to the site of interest and absorption in the GIT. Pharmaceutical scientists worldwide have been interested in colon drug delivery for several decades, not only for the delivery of the drugs for the treatment of colonic diseases such as ulcerative colitis and colon cancer but also for delivery of therapeutic proteins and peptides for systemic absorption...
April 2017: International Journal of Pharmaceutical Investigation
https://www.readbyqxmd.com/read/28884493/endoscopic-submucosal-dissection-in-the-west-current-status-and-future-directions
#3
REVIEW
Michael X Ma, Michael J Bourke
Endoscopic submucosal dissection (ESD) was first conceptually described almost 30 years ago in Japan and is now widely practiced throughout East Asia. ESD expands the boundaries of endoscopic resection (ER) by allowing en bloc resection of large early neoplastic lesions within the gastrointestinal tract (GIT). This offers advantages over other ER techniques by facilitating definitive histological staging and curative treatment of early cancer in selected cases. Indeed the experience of ESD in Eastern countries is significant, and excellent outcomes from high volume centres are reported...
September 7, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28876657/colorectal-cancer-in-a-south-africa-urban-setting-a-preliminary-analysis
#4
L M Prodehl, B Bebington, J Fabian, E Singh, P Ruff
BACKGROUND: Colorectal cancer (CRC) is the second most common cancer in the world, with an estimated incidence in South Africa of 4-5% of all cancers . Studies show that whites account for the majority of South African patients but blacks for the majority of patients under the age of 50. METHOD: This was a preliminary analysis of the first 113 patients enrolled in a prospective longitudinal study. All CRC patients presenting to the teaching hospitals of the Department of Surgery, University of the Witwatersrand were eligible for inclusion...
June 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28876560/what-is-the-diagnostic-yield-of-colonoscopy-in-patients-with-a-referral-diagnosis-of-constipation-in-south-africa
#5
M Mjoli, V Govindasamy, T E Madiba
BACKGROUND: Constipation is a common problem for referral to surgical and colorectal units. Its association with colorectal cancer is controversial. Some authors have found an increased incidence while others have not. The aim of this study is to investigate the incidence of colorectal cancer (CRC) and other significant colonoscopic pathologies in patients undergoing colonoscopy for constipation. METHOD: All colonoscopy reports for constipation were retrieved from our database from January 2011 to 30 June 2014...
September 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28770892/human-epidermal-growth-factor-her-2-in-gastric-and-colorectal-adenocarcinoma
#6
Asma Shabbir, Muhammad Asif Qureshi, Talat Mirza, Abdullah Bin Khalid
Gastrointestinal (GIT) malignancies are a substantial health concern. Most patients present to the clinics with advanced and un-resectable diseases, so it remains difficult to cure with the existing chemotherapeutic regimes. It is therefore extremely important to devise novel therapeutic targets in these neoplasms in order to improve patient's survival. One such target is human epidermal growth factor, also known as Her-2. Although Her-2 expression and the use of a-Her-2 medications in breast cancers is well established, but its expression and potential use as a therapeutic target in gastrointestinal malignancies remains controversial and heavily debated...
July 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28648876/triple-negative-invasive-lobular-carcinoma-of-the-breast-presents-as-small-bowel-obstruction
#7
Mariya Khokhlova, Heidi Roppelt, Bradley Gluck, Jingxuan Liu, Kester Haye, Sang Pak, Edna Kapenhas
Metastasis from breast carcinoma to the gastrointestinal tract (GIT) is very uncommon. To date, only a few cases have been described worldwide. Of those which do metastasize to the GIT, only estrogen receptor (ER), progesterone receptor (PR) and HER2-neu receptor positive cancers have been reported and none have been mentioned in the U.S. We report a case of a 70-year-old white female with history of triple negative lobular carcinoma eight years earlier who presented with solitary jejunal mass causing obstruction...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28576553/phosphate-crosslinked-pectin-based-dual-responsive-hydrogel-networks-and-nanocomposites-development-swelling-dynamics-and-drug-release-characteristics
#8
S Eswaramma, N Sivagangi Reddy, K S V Krishna Rao
Potential dual responsive hydrogel networks (PPAD) are fabricated from pectin, poly((2-dimethylamino)ethyl methacrylate)) and phosphate crosslinker bis[2-methacryloyloxy] ethyl phosphate (BMEP) by a simple free radical polymerization. These hydrogel networks are successfully utilized for encapsulation of an anti-cancer drug, 5-fluorouracil (5-FU) and also employed as versatile platforms for production of silver nanoparticles. Fabricated hydrogel networks and silver nanocomposites were characterized by FTIR, SEM, EDX, TEM, DLS, DSC, TGA and XRD...
October 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28276727/evaluation-of-prothrombin-induced-by-vitamin-k-absence-macrophage-migration-inhibitory-factor-and-golgi-protein-73-versus-alpha-fetoprotein-for-hepatocellular-carcinoma-diagnosis-and-surveillance
#9
Manar M Ismail, Heba K Morsi, Nahla A B Abdulateef, Maissa K Noaman, Ghada A Abou El-Ella
Hepatocellular carcinoma (HCC) represents a challenging malignancy of worldwide importance. It is the third most common cause of cancer-related death globally as most patients present with unresectable disease. Alpha-fetoprotein (AFP) is the widely and solely used biomarker for HCC diagnosis; yet, its usefulness is hampered by low sensitivity and specificity. We aimed to identify more sensitive biomarkers for HCC diagnosis and a surveillance algorithm that may facilitate early detection of HCC. A total of 305 Egyptian and Saudi participants grouped as healthy controls, cancer controls, benign hepatic lesions, chronic viral hepatitis and HCC were included...
May 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/28214467/paxillin-a-crossroad-in-pathological-cell-migration
#10
REVIEW
Ana María López-Colomé, Irene Lee-Rivera, Regina Benavides-Hidalgo, Edith López
Paxilllin is a multifunctional and multidomain focal adhesion adapter protein which serves an important scaffolding role at focal adhesions by recruiting structural and signaling molecules involved in cell movement and migration, when phosphorylated on specific Tyr and Ser residues. Upon integrin engagement with extracellular matrix, paxillin is phosphorylated at Tyr31, Tyr118, Ser188, and Ser190, activating numerous signaling cascades which promote cell migration, indicating that the regulation of adhesion dynamics is under the control of a complex display of signaling mechanisms...
February 18, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28135856/promoter-hypermethylation-and-its-impact-on-expression-of-mgmt-gene-in-the-git-malignant-patients-of-kashmiri-origin
#11
Arif Akbar Bhat, Hilal Ahmad Wani, Shiekh Ishaq, Ajaz Ahmad Waza, Rawoof Ahmad Malik, Iram Shabir, Showkat Jeelani, Showkat Kadla, Waseem Qureshie, Akbar Masood, Sabhiya Majid
Epigenetic alterations, in addition to multiple gene abnormalities, are involved in the genesis and progression of human cancers. Gastrointestinal tract (GIT) cancer is a major medical and economic burden worldwide. Aberrant methylation of CpG islands within promoter regions is associated with transcriptional inactivation of various tumor suppressor genes. Although a number of cancer-associated genes have been found to be hypermethylated in GIT cancer, valuable methylation markers for early diagnosis and prognostic evaluation of this cancer remain largely unknown...
February 7, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/27994031/flexible-model-based-clustering-of-mixed-binary-and-continuous-data-application-to-genetic-regulation-and-cancer
#12
Fatin N Zainul Abidin, David R Westhead
Clustering is used widely in 'omics' studies and is often tackled with standard methods, e.g. hierarchical clustering. However, the increasing need for integration of multiple data sets leads to a requirement for clustering methods applicable to mixed data types, where the straightforward application of standard methods is not necessarily the best approach. A particularly common problem involves clustering entities characterized by a mixture of binary data (e.g. presence/absence of mutations, binding, motifs and epigenetic marks) and continuous data (e...
April 20, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/27716085/clinical-significance-of-incidental-18%C3%A2-f-fdg-uptake-in-the-gastrointestinal-tract-on-pet-ct-imaging-a-retrospective-cohort-study
#13
Eugenia Shmidt, Vandana Nehra, Val Lowe, Amy S Oxentenko
BACKGROUND: The frequency and clinically important characteristics of incidental (18)F-fluorodeoxyglucose ([18 F]FDG) positron emission tomography (PET) uptake in the gastrointestinal tract (GIT) on PET/CT imaging in adults remain elusive. METHODS: All PET/CT reports from 1/1/2000 to 12/31/2009 at a single tertiary referral center were reviewed; clinical information was obtained from cases with incidental (18)F-FDG uptake in the GIT, with follow-up through October, 2012...
October 6, 2016: BMC Gastroenterology
https://www.readbyqxmd.com/read/27596990/cancer-survivors-perspectives-and-experiences-regarding-behavioral-determinants-of-return-to-work-and-continuation-of-work
#14
Saskia F A Duijts, Martine P van Egmond, Maxime Gits, Allard J van der Beek, Eveline M Bleiker
PURPOSE: Supportive interventions to enhance return to work (RTW) in cancer survivors hardly showed positive effects so far. Behavioral determinants might have to be considered in the development of interventions to achieve sustained employability. This study aimed to explore cancer survivors' perspectives and experiences regarding behavioral determinants of RTW and continuation of work. MATERIALS AND METHODS: In this qualitative study, semi-structured telephone interviews were held with 28 cancer survivors...
September 6, 2016: Disability and Rehabilitation
https://www.readbyqxmd.com/read/27587658/complementary-feature-selection-from-alternative-splicing-events-and-gene-expression-for-phenotype-prediction
#15
Charles J Labuzzetta, Margaret L Antonio, Patricia M Watson, Robert C Wilson, Lauren A Laboissonniere, Jeffrey M Trimarchi, Baris Genc, P Hande Ozdinler, Dennis K Watson, Paul E Anderson
MOTIVATION: A central task of bioinformatics is to develop sensitive and specific means of providing medical prognoses from biomarker patterns. Common methods to predict phenotypes in RNA-Seq datasets utilize machine learning algorithms trained via gene expression. Isoforms, however, generated from alternative splicing, may provide a novel and complementary set of transcripts for phenotype prediction. In contrast to gene expression, the number of isoforms increases significantly due to numerous alternative splicing patterns, resulting in a prioritization problem for many machine learning algorithms...
September 1, 2016: Bioinformatics
https://www.readbyqxmd.com/read/27556544/reliability-of-nutritional-assessment-in-patients-with-gastrointestinal-tumors
#16
Aline Kirjner Poziomyck, Ana Valeria Gonçalves Fruchtenicht, Georgia Brum Kabke, Bernardo Silveira Volkweis, Jorge Luiz Antoniazzi, Luis Fernando Moreira
Patients with gastrointestinal cancer and malnutrition are less likely to tolerate major surgical procedures, radiotherapy or chemotherapy. In general, they display a higher incidence of complications such as infection, dehiscence and sepsis, which increases the length of stay and risk of death, and reduces quality of life. The aim of this review is to discuss the pros and cons of different points of view to assess nutritional risk in patients with gastrointestinal tract (GIT) tumors and their viability, considering the current understanding and screening approaches in the field...
May 2016: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/27397719/chitosan-based-nano-in-microparticle-carriers-for-enhanced-oral-delivery-and-anticancer-activity-of-propolis
#17
Nancy M Elbaz, Islam A Khalil, Ahmed A Abd-Rabou, Ibrahim M El-Sherbiny
This study reports a promising approach to enhance the oral delivery of propolis, improve its aqueous solubility and bioavailability, and allow its controlled release as well as enhancing its anticancer activity. Propolis was standardized then its solubility was improved via formulation into optimized solid dispersion (SD) matrices, and its release was controlled through incorporation into nanoparticles (NPs) of optimized composition followed by further inclusion into chitosan (Cs) microparticles. The anticancer activity of the newly developed propolis-loaded nano-in-microparticles (NIMs) was evaluated against human liver cancer (HepG2) and human colorectal cancer (HCT 116) cells...
November 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27372029/testicular-seminoma-metastasis-to-duodenum-misdiagnosed-as-primary-duodenal-tumor
#18
Amer Hashim Al Ani, Hashim Amer Al Ani
INTRODUCTION: Testicular cancer is the most common malignancy in Males aged 15-35 years. Its incidence comprises 0.8% of all Male cancers worldwide, with a mortality rate of 0.1%. Rarely it metastasizes to the retroperitoneum and invades upper gastrointestinal tract (GIT). Complications like intestinal obstruction, hemorrhage, and perforation are usually present. PRESENTATION OF CASE: We report a 30 year-old male, presented to GIT unit with severe anemia due to upper GIT bleeding...
2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27341105/amrubicin-in-patients-with-platinum-refractory-metastatic-neuroendocrine-carcinoma-and-mixed-adenoneuroendocrine-carcinoma-of-the-gastrointestinal-tract
#19
Tomonori Araki, Atsuo Takashima, Tetsuya Hamaguchi, Yoshitaka Honma, Satoru Iwasa, Natsuko Okita, Ken Kato, Yasuhide Yamada, Hironobu Hashimoto, Hirokazu Taniguchi, Ryoji Kushima, Kazuhiko Nakao, Narikazu Boku, Yasuhiro Shimada
Although the same treatment strategy as used for small cell lung cancer, including second-line chemotherapy, is generally applied to metastatic neuroendocrine carcinoma (NEC) and mixed adenoneuroendocrine carcinoma (MANEC) of the gastrointestinal tract (GIT; GIT-NEC/MANEC), the efficacy of amrubicin (AMR) for GIT-NEC/MANEC is not well known. We retrospectively analyzed platinum-refractory GIT-NEC/MANEC patients who received AMR between February 2004 and July 2012 at the National Cancer Center Hospital. The AMR dose administered was 30-45 mg/m on days 1-3 every 3-4 weeks...
September 2016: Anti-cancer Drugs
https://www.readbyqxmd.com/read/27240747/protective-effect-and-potential-mechanisms-of-wei-chang-an-pill-on-high-dose-5-fluorouracil-induced-intestinal-mucositis-in-mice
#20
Yuling Chen, Hong Zheng, Jingze Zhang, Lei Wang, Zhaoxiang Jin, Wenyuan Gao
ETHNOPHARMACOLOGICAL RELEVANCE: Wei-Chang-An pill (WCA pill), a traditional Chinese pharmaceutical preparation, possessed potential anti-inflammatory advantages and noteworthy gastrointestinal regulations in digestive diseases, which might represent a promising candidate for the treatment of intestinal mucositis (IM) induced by 5-fluorouracil (5-FU). AIM OF THE STUDY: To analyze the bioactive constituents and investigate the effect of methanol extraction from WCA pill (WCA ext) on 5-FU induced IM with underlying mechanisms...
August 22, 2016: Journal of Ethnopharmacology
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