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Git cancer

Manar M Ismail, Heba K Morsi, Nahla A B Abdulateef, Maissa K Noaman, Ghada A Abou El-Ella
Hepatocellular carcinoma (HCC) represents a challenging malignancy of worldwide importance. It is the third most common cause of cancer-related death globally as most patients present with unresectable disease. Alpha-fetoprotein (AFP) is the widely and solely used biomarker for HCC diagnosis; yet, its usefulness is hampered by low sensitivity and specificity. We aimed to identify more sensitive biomarkers for HCC diagnosis and a surveillance algorithm that may facilitate early detection of HCC. A total of 305 Egyptian and Saudi participants grouped as healthy controls, cancer controls, benign hepatic lesions, chronic viral hepatitis and HCC were included...
May 2017: Scandinavian Journal of Clinical and Laboratory Investigation
Ana María López-Colomé, Irene Lee-Rivera, Regina Benavides-Hidalgo, Edith López
Paxilllin is a multifunctional and multidomain focal adhesion adapter protein which serves an important scaffolding role at focal adhesions by recruiting structural and signaling molecules involved in cell movement and migration, when phosphorylated on specific Tyr and Ser residues. Upon integrin engagement with extracellular matrix, paxillin is phosphorylated at Tyr31, Tyr118, Ser188, and Ser190, activating numerous signaling cascades which promote cell migration, indicating that the regulation of adhesion dynamics is under the control of a complex display of signaling mechanisms...
February 18, 2017: Journal of Hematology & Oncology
Arif Akbar Bhat, Hilal Ahmad Wani, Shiekh Ishaq, Ajaz Ahmad Waza, Rawoof Ahmad Malik, Iram Shabir, Showkat Jeelani, Showkat Kadla, Waseem Qureshie, Akbar Masood, Sabhiya Majid
Epigenetic alterations, in addition to multiple gene abnormalities, are involved in the genesis and progression of human cancers. Gastrointestinal tract (GIT) cancer is a major medical and economic burden worldwide. Aberrant methylation of CpG islands within promoter regions is associated with transcriptional inactivation of various tumor suppressor genes. Although a number of cancer-associated genes have been found to be hypermethylated in GIT cancer, valuable methylation markers for early diagnosis and prognostic evaluation of this cancer remain largely unknown...
February 7, 2017: Cancer Investigation
Fatin N Zainul Abidin, David R Westhead
Clustering is used widely in 'omics' studies and is often tackled with standard methods, e.g. hierarchical clustering. However, the increasing need for integration of multiple data sets leads to a requirement for clustering methods applicable to mixed data types, where the straightforward application of standard methods is not necessarily the best approach. A particularly common problem involves clustering entities characterized by a mixture of binary data (e.g. presence/absence of mutations, binding, motifs and epigenetic marks) and continuous data (e...
April 20, 2017: Nucleic Acids Research
Eugenia Shmidt, Vandana Nehra, Val Lowe, Amy S Oxentenko
BACKGROUND: The frequency and clinically important characteristics of incidental (18)F-fluorodeoxyglucose ([18 F]FDG) positron emission tomography (PET) uptake in the gastrointestinal tract (GIT) on PET/CT imaging in adults remain elusive. METHODS: All PET/CT reports from 1/1/2000 to 12/31/2009 at a single tertiary referral center were reviewed; clinical information was obtained from cases with incidental (18)F-FDG uptake in the GIT, with follow-up through October, 2012...
October 6, 2016: BMC Gastroenterology
Saskia F A Duijts, Martine P van Egmond, Maxime Gits, Allard J van der Beek, Eveline M Bleiker
PURPOSE: Supportive interventions to enhance return to work (RTW) in cancer survivors hardly showed positive effects so far. Behavioral determinants might have to be considered in the development of interventions to achieve sustained employability. This study aimed to explore cancer survivors' perspectives and experiences regarding behavioral determinants of RTW and continuation of work. MATERIALS AND METHODS: In this qualitative study, semi-structured telephone interviews were held with 28 cancer survivors...
September 6, 2016: Disability and Rehabilitation
Charles J Labuzzetta, Margaret L Antonio, Patricia M Watson, Robert C Wilson, Lauren A Laboissonniere, Jeffrey M Trimarchi, Baris Genc, P Hande Ozdinler, Dennis K Watson, Paul E Anderson
MOTIVATION: A central task of bioinformatics is to develop sensitive and specific means of providing medical prognoses from biomarker patterns. Common methods to predict phenotypes in RNA-Seq datasets utilize machine learning algorithms trained via gene expression. Isoforms, however, generated from alternative splicing, may provide a novel and complementary set of transcripts for phenotype prediction. In contrast to gene expression, the number of isoforms increases significantly due to numerous alternative splicing patterns, resulting in a prioritization problem for many machine learning algorithms...
September 1, 2016: Bioinformatics
Aline Kirjner Poziomyck, Ana Valeria Gonçalves Fruchtenicht, Georgia Brum Kabke, Bernardo Silveira Volkweis, Jorge Luiz Antoniazzi, Luis Fernando Moreira
Patients with gastrointestinal cancer and malnutrition are less likely to tolerate major surgical procedures, radiotherapy or chemotherapy. In general, they display a higher incidence of complications such as infection, dehiscence and sepsis, which increases the length of stay and risk of death, and reduces quality of life. The aim of this review is to discuss the pros and cons of different points of view to assess nutritional risk in patients with gastrointestinal tract (GIT) tumors and their viability, considering the current understanding and screening approaches in the field...
May 2016: Revista do Colégio Brasileiro de Cirurgiões
Nancy M Elbaz, Islam A Khalil, Ahmed A Abd-Rabou, Ibrahim M El-Sherbiny
This study reports a promising approach to enhance the oral delivery of propolis, improve its aqueous solubility and bioavailability, and allow its controlled release as well as enhancing its anticancer activity. Propolis was standardized then its solubility was improved via formulation into optimized solid dispersion (SD) matrices, and its release was controlled through incorporation into nanoparticles (NPs) of optimized composition followed by further inclusion into chitosan (Cs) microparticles. The anticancer activity of the newly developed propolis-loaded nano-in-microparticles (NIMs) was evaluated against human liver cancer (HepG2) and human colorectal cancer (HCT 116) cells...
November 2016: International Journal of Biological Macromolecules
Amer Hashim Al Ani, Hashim Amer Al Ani
INTRODUCTION: Testicular cancer is the most common malignancy in Males aged 15-35 years. Its incidence comprises 0.8% of all Male cancers worldwide, with a mortality rate of 0.1%. Rarely it metastasizes to the retroperitoneum and invades upper gastrointestinal tract (GIT). Complications like intestinal obstruction, hemorrhage, and perforation are usually present. PRESENTATION OF CASE: We report a 30 year-old male, presented to GIT unit with severe anemia due to upper GIT bleeding...
2016: International Journal of Surgery Case Reports
Tomonori Araki, Atsuo Takashima, Tetsuya Hamaguchi, Yoshitaka Honma, Satoru Iwasa, Natsuko Okita, Ken Kato, Yasuhide Yamada, Hironobu Hashimoto, Hirokazu Taniguchi, Ryoji Kushima, Kazuhiko Nakao, Narikazu Boku, Yasuhiro Shimada
Although the same treatment strategy as used for small cell lung cancer, including second-line chemotherapy, is generally applied to metastatic neuroendocrine carcinoma (NEC) and mixed adenoneuroendocrine carcinoma (MANEC) of the gastrointestinal tract (GIT; GIT-NEC/MANEC), the efficacy of amrubicin (AMR) for GIT-NEC/MANEC is not well known. We retrospectively analyzed platinum-refractory GIT-NEC/MANEC patients who received AMR between February 2004 and July 2012 at the National Cancer Center Hospital. The AMR dose administered was 30-45 mg/m on days 1-3 every 3-4 weeks...
September 2016: Anti-cancer Drugs
Yuling Chen, Hong Zheng, Jingze Zhang, Lei Wang, Zhaoxiang Jin, Wenyuan Gao
ETHNOPHARMACOLOGICAL RELEVANCE: Wei-Chang-An pill (WCA pill), a traditional Chinese pharmaceutical preparation, possessed potential anti-inflammatory advantages and noteworthy gastrointestinal regulations in digestive diseases, which might represent a promising candidate for the treatment of intestinal mucositis (IM) induced by 5-fluorouracil (5-FU). AIM OF THE STUDY: To analyze the bioactive constituents and investigate the effect of methanol extraction from WCA pill (WCA ext) on 5-FU induced IM with underlying mechanisms...
August 22, 2016: Journal of Ethnopharmacology
Randeep Singh, Rashmi Shirali, Sonali Chatterjee, Arun Adhana, Ramandeep Singh Arora
BACKGROUND AND OBJECTIVES: Although cancer in adolescents and young adults (AYAs) is increasingly an area of focus, there is a paucity of clinical and epidemiological data from developing countries. Our objective was to analyze the geographical distribution, sex ratio, histology, and disease patterns of cancers in AYA. MATERIALS AND METHODS: All patients aged 15-29 years with the diagnosis of cancer who were registered with two hospitals in New Delhi during a 12-month period from January 2014 to December 2014 were included...
April 2016: Indian Journal of Medical and Paediatric Oncology
Sufang Wang, Michael Gribskov, Tony R Hazbun, Pete E Pascuzzi
UNLABELLED: The NCI-60 human tumor cell line panel is an invaluable resource for cancer researchers, providing drug sensitivity, molecular and phenotypic data for a range of cancer types. CellMiner is a web resource that provides tools for the acquisition and analysis of quality-controlled NCI-60 data. CellMiner supports queries of up to 150 drugs or genes, but the output is an Excel file for each drug or gene. This output format makes it difficult for researchers to explore the data from large queries...
August 1, 2016: Bioinformatics
Vilde D Haakensen, Vegard Nygaard, Liliana Greger, Miriam R Aure, Bastian Fromm, Ida R K Bukholm, Torben Lüders, Suet-Feung Chin, Anna Git, Carlos Caldas, Vessela N Kristensen, Alvis Brazma, Anne-Lise Børresen-Dale, Eivind Hovig, Åslaug Helland
Robust markers of invasiveness may help reduce the overtreatment of in situ carcinomas. Breast cancer is a heterogeneous disease and biological mechanisms for carcinogenesis vary between subtypes. Stratification by subtype is therefore necessary to identify relevant and robust signatures of invasive disease. We have identified microRNA (miRNA) alterations during breast cancer progression in two separate datasets and used stratification and external validation to strengthen the findings. We analyzed two separate datasets (METABRIC and AHUS) consisting of a total of 186 normal breast tissue samples, 18 ductal carcinoma in situ (DCIS) and 1,338 invasive breast carcinomas...
September 1, 2016: International Journal of Cancer. Journal International du Cancer
Andon Chibishev, Velo Markoski, Ivica Smokovski, Emilija Shikole, Aleksandra Stevcevska
INTRODUCTION: Acute intoxications with corrosive substances can cause severe chemical injuries of the upper gastrointestinal tract, most often located in the mouth, pharynx, esophagus, stomach and duodenum. If a patient survives the acute phase of intoxication, regenerative response may result in esophageal and/or gastric stenosis, and increased risk of esophageal and gastric cancer. Such intoxication may be fatal due to perforation or tracheal necrosis. Enteral nutrition is a nutritional method when nutritional substances are administered through specially designed tubing placed through the nose or percutaneously, directly into the GIT...
February 2016: Materia Socio-medica
N R Hussein, Z S M Saleem, A A Balatay, K H Abd, S Daniel, A A Taha, N M R Ibrahim, M S Assafi
INTRODUCTION: Helicobacter pylori plays an important role in the development of gastritis, peptic ulcer disease, and gastric cancer in the general population. Although dyspeptic complaints are frequent in renal transplant subjects, the role of H pylori in such complaints is not clear. This study was conducted to examine the prevalence of H pylori infection in patients with renal transplant and its role in the development of upper gastrointestinal tract (GIT) symptoms. MATERIALS AND METHODS: We compared the prevalence of H pylori in 109 renal transplant subjects with the prevalence of 161 healthy volunteers using an enzyme-linked immunosorbent assay to measure anti-H pylori IgG...
January 2016: Transplantation Proceedings
F Pace, M Pace, G Quartarone
Probiotics are becoming increasingly important in basic and clinical research, but they are also a subject of considerable economic interest due to their expanding popularity. They are live micro-organisms which, when administered in adequate amounts, confer a health benefit to the host. From this very well-known definition, it is clear that, unlike drugs, probiotics might be useful in healthy subjects to reduce the risk of developing certain diseases or to optimise some physiological functions. They also may offer some advantages in already ill persons in relieving symptoms and signs, e...
December 2015: Minerva Gastroenterologica e Dietologica
Juliette Vella-Boucaud, Dimitri Papathanassiou, Olivier Bouche, Alain Prevost, Thibault Lestra, Sandra Dury, Hervé Vallerand, Jeanne-Marie Perotin, Claire Launois, Louis Boissiere, Mathilde Brasseur, François Lebargy, Gaëtan Deslee
BACKGROUND: F-Fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) is increasingly used for the initial staging and restaging of lung cancer. Incidental gastrointestinal findings are often observed on (18)F-FDG PET/CT. The objective of this study was to assess incidental 18F-FDG uptake by the gastrointestinal tract (GIT) in patients with lung cancer. METHODS: Two hundred thirty consecutive 18F-FDG PET/CT examinations performed for lung cancer over a 3-year period were retrospectively reviewed for the presence of incidental FDG uptake in the GIT...
2015: BMC Pulmonary Medicine
Haoming Xu, Mohammad Ali Moni, Pietro Liò
In cancer genomics, gene expression levels provide important molecular signatures for all types of cancer, and this could be very useful for predicting the survival of cancer patients. However, the main challenge of gene expression data analysis is high dimensionality, and microarray is characterised by few number of samples with large number of genes. To overcome this problem, a variety of penalised Cox proportional hazard models have been proposed. We introduce a novel network regularised Cox proportional hazard model and a novel multiplex network model to measure the disease comorbidities and to predict survival of the cancer patient...
December 2015: Computational Biology and Chemistry
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