Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#21
JOURNAL ARTICLE
Katerina Deike, Andreas Decker, Paul Scheyhing, Julia Harten, Nadine Zimmermann, Daniel Paech, Oliver Peters, Silka D Freiesleben, Luisa-Sophie Schneider, Lukas Preis, Josef Priller, Eike Spruth, Slawek Altenstein, Andrea Lohse, Klaus Fliessbach, Okka Kimmich, Jens Wiltfang, Claudia Bartels, Niels Hansen, Frank Jessen, Ayda Rostamzadeh, Emrah Düzel, Wenzel Glanz, Enise I Incesoy, Michaela Butryn, Katharina Buerger, Daniel Janowitz, Michael Ewers, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Kilimann, Doreen Goerss, Christoph Laske, Matthias H Munk, Annika Spottke, Nina Roy, Michael Wagner, Sandra Roeske, Michael T Heneka, Frederic Brosseron, Alfredo Ramirez, Laura Dobisch, Steffen Wolfsgruber, Luca Kleineidam, Renat Yakupov, Melina Stark, Matthias C Schmid, Moritz Berger, Stefan Hetzer, Peter Dechent, Klaus Scheffler, Gabor C Petzold, Anja Schneider, Alexander Effland, Alexander Radbruch
OBJECTIVES: Impaired perivascular clearance has been suggested as a contributing factor to the pathogenesis of Alzheimer disease (AD). However, it remains unresolved when the anatomy of the perivascular space (PVS) is altered during AD progression. Therefore, this study investigates the association between PVS volume and AD progression in cognitively unimpaired (CU) individuals, both with and without subjective cognitive decline (SCD), and in those clinically diagnosed with mild cognitive impairment (MCI) or mild AD...
April 23, 2024: Investigative Radiology
#22
JOURNAL ARTICLE
Hubinský Marcel, Hobza Roman, Marta Starczak, Gackowski Daniel, Kubát Zdeněk, Janíček Tomáš, Horáková Lucie, Jose Luis Rodriguez Lorenzo
The oxidation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC), known as oxi-mCs, garners significant interest in plants as potential epigenetic marks. While research in mammals has established a role in cell reprogramming, carcinogenesis and gene regulation, their functions in plants remain unclear. In rice, 5hmC has been associated with transposable elements and heterochromatin. This study utilizes Silene latifolia, a dioecious plant with heteromorphic sex chromosomes and a genome with a large proportion of transposable elements, which provides a favourable environment for the study of oxi-mCs in individual sexes...
April 23, 2024: Journal of Experimental Botany
#23
JOURNAL ARTICLE
Suho Lee, Ji Hyun Bak, Yuno Lee, Dae-Woong Jeong, Jaehee Lee, KeunMin Ken Lee, Hasaeam Cho, Hyun Hwi Lee, Changbong Hyeon, Myung Chul Choi
Lipid rafts, which are dynamic nanodomains in the plasma membrane, play a crucial role in intermembrane processes by clustering together and growing in size within the plane of the membrane while also aligning with each other across different membranes. However, the physical origin of layer by layer alignment of lipid rafts remains to be elucidated. Here, by using fluorescence imaging and synchrotron X-ray reflectivity in a phase-separated multilayer system, we find that the alignment of raft-mimicking Lo domains is regulated by the distance between bilayers...
April 23, 2024: Journal of the American Chemical Society
#24
JOURNAL ARTICLE
Xiaoxi Luo, Jie Kong, Hang Xiao, Dongmiao Sang, Kui He, Meng Zhou, Jinbin Liu
Designing luminophores bright in both isolate species and aggregate states is of great importance in many emerging cutting-edge applications. However, the conventional luminophores either emit in isolate species but quench in aggregate state or emit in aggregate state but darken in isolate species. Here we demonstrate that the precise regulation of noncovalent interactions can realize luminophores bright in both isolate species and aggregate states. It is firstly discovered that the intra-cluster interaction enhances the emission of atomically precise Au25(pMBA)18 (pMBA = 4-mercaptobenzoic acid), a nanoscale luminophore, while the inter-cluster interaction quenches the emission...
April 23, 2024: Angewandte Chemie
#25
JOURNAL ARTICLE
Caroline Wang, Natalie Miller, Douglas Vines, Paul M Severns, Michelle Momany, Marin T Brewer
Aspergillus fumigatus is a ubiquitous saprotroph and human-pathogenic fungus that is life-threatening to the immunocompromised. Triazole-resistant A. fumigatus was found in patients without prior treatment with azoles, leading researchers to conclude that resistance had developed in agricultural environments where azoles are used against plant pathogens. Previous studies have documented azole-resistant A. fumigatus across agricultural environments, but few have looked at retail plant products. Our objectives were to determine if azole-resistant A...
April 23, 2024: Applied and Environmental Microbiology
#26
JOURNAL ARTICLE
Anne-Sophie Le Guern, Cyril Savin, Fanny Chereau, Sabrina Tessier, Julien Guglielmini, Sylvie Brémont, Javier Pizarro-Cerdá
UNLABELLED: Enteric yersiniosis, the third most common food-borne zoonosis in Europe, is mainly caused by the pathogen Yersinia enterocolitica . In France , the yersiniosis microbiological surveillance is conducted at the Yersinia National Reference Laboratory (YNRL). Since 2017, isolates have been characterized by whole genome sequencing (WGS) followed by a 500-gene Yersinia -cgMLST. We report here the data of the WGS-based surveillance on Y. enterocolitica isolates for the 2017-2021 period...
April 23, 2024: Microbiology Spectrum
#27
JOURNAL ARTICLE
Anne T Berg, Christopher H Thompson, Leah Schust Myers, Erica Anderson, Lindsey Evans, Ariela J E Kaiser, Katherine Paltell, Amanda N Nili, Jean-Marc DeKeyser, Tatiana V Abramova, Gerry Nesbitt, Shawn Egan, Carlos G Vanoye, Alfred L George
SCN2A-related disorders secondary to altered function in the voltage-gated sodium channel NaV1.2 are rare with clinically heterogeneous expressions that include epilepsy, autism, and multiple severe to profound impairments and other conditions. To advance understanding of the clinical phenotypes and their relation to channel function, 81 patients (36, 44% female, median age 5.4 years) with 69 unique SCN2A variants were systematically phenotyped and their NaV1.2 channel function systematically assessed. Participants were recruited through the FamileSCN2A Foundation...
April 23, 2024: Brain
#28
JOURNAL ARTICLE
Xi-Guan Zhao, Qi Yang, Ying Xu, Qing-Yu Liu, Zi-Yu Li, Xiao-Xiao Liu, Yan-Xia Zhao, Sheng-Gui He
Understanding the mechanisms of C-H activation of alkanes is a very important research topic. The reactions of metal clusters with alkanes have been extensively studied to reveal the electronic features governing C-H activation, while the experimental cluster reactivity was qualitatively interpreted case by case in the literature. Herein, we prepared and mass-selected over 100 rhodium-based clusters (Rh x V y O z - and Rh x Co y O z - ) to react with light alkanes, enabling the determination of reaction rate constants spanning six orders of magnitude...
April 23, 2024: Journal of the American Chemical Society
#29
JOURNAL ARTICLE
Peyton Carden, Sirui Ge, Bingrui Li, Subarna Samanta, Alexei P Sokolov
The topic of polymers with dynamic bonds (stickers) appears as an exciting and promising area of materials science, thanks to their attractive self-healable, recyclable, extremely tough, and super extensible properties. Polymers with phase separated dynamic bonds revealed several unique properties, but mechanisms controlling their viscoelastic properties remain poorly understood. In this work, we present a dynamic analysis of a model polymer system with phase separated hydrogen bonding functionalities. The results confirm that terminal relaxation in these systems is independent of polymer segmental dynamics and is instead controlled by structural relaxations in clusters of stickers...
April 23, 2024: Soft Matter
#30
JOURNAL ARTICLE
Zhihao Yao, Kaiyu He, Hongmei Wang, Suyin Feng, Xiaoqing Ding, Yan Xu, Qiang Wang, Xiahong Xu, Qun Wu, Liu Wang
Excavating nucleic acid quantitative capabilities by combining clustered regularly interspaced short palindromic repeats (CRISPR) and isothermal amplification in one pot is of common interest. However, the mutual interference between CRISPR cleavage and isothermal amplification is the primary obstacle to quantitative detection. Though several works have demonstrated enhanced detection sensitivity by reducing the inhibition of CRISPR on amplification in one pot, few paid attention to the amplification process and even dynamic reaction processes between the two...
April 23, 2024: ACS Sensors
#31
JOURNAL ARTICLE
Weikang Wang, Shaobin Mei, Shahid Khan, Yujue Hu, Lijuan Sun, Muhammad Adnan Qaiser, Chengzhang Zhu, Lele Wang, Qinqin Liu
Simultaneous utilization of photogenerated electrons and holes to achieve overall redox reactions is attractive but still far from practical application. The emerging step (S)-scheme mechanism has proven to be an ideal approach to inhibit charge recombination and supply photoinduced charges with highest redox potentials. Herein, a hierarchical phosphotungstic acid (H3PW12O40, HPW)@Znln2S4 (ZISW) heterojunction was prepared through one-pot hydrothermal method for simultaneous hydrogen (H2) evolution and benzyl alcohol upgrading...
April 23, 2024: ChemSusChem
#32
REVIEW
Takamasa Tsukamoto
Despite its potential significance, "cluster chemistry" remains a somewhat marginalized topic within the chemistry field. However, atomic clusters with their unusual and unique structures and properties represent a novel material group situated between molecules and nanoparticles or solid matter, judging from both scientific standpoints and historical backgrounds. Surveying an entire material group, including all substances that can be regarded as a cluster, is essential for establishing cluster chemistry as a more prominent chemistry field...
April 23, 2024: Nanoscale
#33
JOURNAL ARTICLE
Hui Sun, Zi-Yi Wang, Ye Han, Xiao-Jing Wei, Yong-Chun Wang, Xue-Fan Yu
OBJECTIVE: The pathological features of immune-mediated necrotizing myopathy (IMNM) are dominated by the infiltration of macrophages. We aimed to perform a histopathologic semiquantitative analysis to investigate the relationship between macrophage markers and prognosis. METHODS: Semiquantitative analysis of histologic features was performed in 62 samples of IMNM. Independent risk factors were identified through univariate and multivariate regression analysis. Cluster analysis was performed using the partitioning around the medoids (PAM) method...
April 23, 2024: Annals of Clinical and Translational Neurology
#34
JOURNAL ARTICLE
Emmanouil Mavrogeorgis, Sophie Valkenburg, Justyna Siwy, Agnieszka Latosinska, Griet Glorieux, Harald Mischak, Joachim Jankowski
Millions of people worldwide currently suffer from chronic kidney disease (CKD), requiring kidney replacement therapy at the end stage. Endeavors to better understand CKD pathophysiology from an omics perspective have revealed major molecular players in several sample sources. Focusing on non-invasive sources, gut microbial communities appear to be disturbed in CKD, while numerous human urinary peptides are also dysregulated. Nevertheless, studies often focus on isolated omics techniques, thus potentially missing the complementary pathophysiological information that multidisciplinary approaches could provide...
April 1, 2024: Proteomes
#35
JOURNAL ARTICLE
Ningxin Jiang, Andrea Darù, Špela Kunstelj, Jenny G Vitillo, Maia E Czaikowski, Alexander S Filatov, Anna Wuttig, Laura Gagliardi, John S Anderson
Iron-sulfur clusters play essential roles in biological systems, and thus synthetic [Fe4 S4 ] clusters have been an area of active research. Recent studies have demonstrated that soluble [Fe4 S4 ] clusters can serve as net H atom transfer mediators, improving the activity and selectivity of a homogeneous Mn CO2 reduction catalyst. Here, we demonstrate that incorporating these [Fe4 S4 ] clusters into a coordination polymer enables heterogeneous H atom transfer from an electrode surface to a Mn complex dissolved in solution...
April 23, 2024: Journal of the American Chemical Society
#36
JOURNAL ARTICLE
Surendra Singh Bisht, R K Meena, Maneesh Bhandari, Prithvi Pal Singh, Upendra Pal Sharma, Aman Bisht, P K Verma
Trillium govanianum, a medicinal herb, exhibiting diverse morphometric traits and phytochemicals across developmental stages of plants. The changes in the chemical profile and steroidal saponin levels in the rhizome of T. govanianum across different developmental stages were previously unknown. This study categorizes rhizomes into three types based on scar presence: juvenile (5-10 scars, Type I), young (11-19 scars, Type II), and mature (21-29 scars, Type III). Rhizomes show varying sizes (length 1.2-4.7 cm, girth 0...
April 23, 2024: Chemistry & Biodiversity
#37
JOURNAL ARTICLE
Tianyuan Zhang, Samragni Banerjee, Lauren N Koulias, Edward F Valeev, A Eugene DePrince, Xiaosong Li
We present a relativistic equation-of-motion coupled-cluster with single and double excitation formalism within the exact two-component framework (X2C-EOM-CCSD), where both scalar relativistic effects and spin-orbit coupling are variationally included at the reference level. Three different molecular mean-field treatments of relativistic corrections, including the one-electron, Dirac-Coulomb, and Dirac-Coulomb-Breit Hamiltonian, are considered in this work. Benchmark calculations include atomic excitations and fine-structure splittings arising from spin-orbit coupling...
April 23, 2024: Journal of Physical Chemistry. A
#38
JOURNAL ARTICLE
Bartosz Trzaskowski, Juan Pablo Martínez, Aleksandra Sarwa, Bartosz Szyszko, William A Goddard
Recently, pyrrole cages have been synthesized that encapsulate ion pairs and silver(I) clusters to form intricate supramolecular capsules. We report here a computational analysis of these structures using density functional theory combined with a semiempirical tight-binding approach. We find that for neutral pyrrole cages, the Gibbs free energies of formation provide reliable predictions for the ratio of bound ions. For charged pyrrole cages, we find strong argentophilic interactions between Ag ions on the basis of the calculated bond indices and molecular orbitals...
April 23, 2024: Journal of Physical Chemistry. A
#39
JOURNAL ARTICLE
Ian Dance
In converting N2 to NH3 the enzyme nitrogenase utilises 8 electrons and 8 protons in the complete catalytic cycle. The source of the electrons is an Fe4 S4 reductase protein (Fe-protein) which temporarily docks with the MoFe-protein that contains the catalytic active cofactor, FeMo-co, and an electron transfer cluster called the P cluster. The overall mechanism involves 8 repetitions of a cycle in which reduced Fe-protein docks with the MoFe-protein, one electron transfers to the P-cluster, and then to FeMo-co, followed by dissociation of the two proteins and re-reduction of the Fe-protein...
April 23, 2024: Dalton Transactions: An International Journal of Inorganic Chemistry
#40
JOURNAL ARTICLE
Elena Sandri, Juan Pardo, Eva Cantín Larumbe, Germán Cerdá Olmedo, Antonio Falcó
AIM: This study aims to analyze some nutrition and health habits of young people and the impact of educational attainment on health. METHODS: An observational, descriptive, and cross-sectional study was carried out using surveys. Using non-probabilistic snowball sampling, a previously validated questionnaire was disseminated through networks, collecting a sample of 9,681 people between 18 and 30 years old. Comparative analyses between groups were obtained by clustering and the corresponding statistical tests...
2024: Frontiers in Public Health
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
