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https://www.readbyqxmd.com/read/29241190/circrna-expression-profile-in-early-stage-lung-adenocarcinoma-patients
#1
Jiangmin Zhao, Le Li, Qian Wang, Hongxiu Han, Qing Zhan, Ming Xu
BACKGROUND/AIMS: Lung adenocarcinoma, a form of non-small cell lung cancer with high lethality at an advanced stage, is becoming more common in women, non- or never-smokers, and even young adults. At present, there are still no effective early diagnosis methods for patients to be cured in a timely manner. Circular RNAs (circRNAs), which are stable and conserved non-coding RNA in mammalian cells, have been reported to be widely involved in the processes of cancer disease. However, it is still a puzzle as to which specific circRNAs are involved in the development of early-stage lung adenocarcinoma...
December 12, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29241124/struvite-formation-and-decomposition-characteristics-for-ammonia-and-phosphorus-recovery-a-review-of-magnesium-ammonia-phosphate-interactions
#2
REVIEW
Berrin Tansel, Griffin Lunn, Oscar Monje
Struvite (MgNH4PO4·6H2O) forms in aqueous systems with high ammonia and phosphate concentrations. However, conditions that result into struvite formation are highly dependent on the ionic compositions, temperature, pH, and ion speciation characteristics. The primary ions involved in struvite formation have complex interactions and can form different crystals depending on the ionic levels, pH and temperature. Struvite as well as struvite analogues (with substitution of monovalent cations for NH4+ or divalent cations for Mg2+) as well as other crystals can form simultaneously and result in changes in crystal morphology during crystal growth...
December 5, 2017: Chemosphere
https://www.readbyqxmd.com/read/29241107/nationwide-analysis-on-the-impact-of-socioeconomic-land-use-factors-and-incidence-of-urothelial-carcinoma
#3
Maximilian P Brandt, Kilian M Gust, Jens Mani, Stefan Vallo, Thomas Höfner, Hendrik Borgmann, Igor Tsaur, Christian Thomas, Axel Haferkamp, Eva Herrmann, Georg Bartsch
BACKGROUND: Incidence rates for urothelial carcinoma (UC) have been reported to differ between countries within the European Union (EU). Besides occupational exposure to chemicals, other substances such as tobacco and nitrite in groundwater have been identified as risk factors for UC. We investigated if regional differences in UC incidence rates are associated with agricultural, industrial and residential land use. METHODS: Newly diagnosed cases of UC between 2003 and 2010 were included...
December 11, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/29240787/brd3-4-inhibition-and-flt3-ligand-deprivation-target-pathways-that-are-essential-for-the-survival-of-human-mll-af9-leukemic-cells
#4
Marco Carretta, Annet Z Brouwers-Vos, Matthieu Bosman, Sarah J Horton, Joost H A Martens, Edo Vellenga, Jan Jacob Schuringa
In the present work we aimed to identify targetable signaling networks in human MLL-AF9 leukemias. We show that MLL-AF9 cells critically depend on FLT3-ligand induced pathways as well as on BRD3/4 for their survival. We evaluated the in vitro and in vivo efficacy of the BRD3/4 inhibitor I-BET151 in various human MLL-AF9 (primary) models and patient samples and analyzed the transcriptome changes following treatment. To further understand the mode of action of BRD3/4 inhibition, we performed ChIP-seq experiments on the MLL-AF9 complex in THP1 cells and compared it to RNA-seq data of I-BET151 treated cells...
2017: PloS One
https://www.readbyqxmd.com/read/29240786/time-trend-analysis-2009-2016-of-antimicrobial-susceptibility-in-neisseria-gonorrhoeae-isolated-in-italy-following-the-introduction-of-the-combined-antimicrobial-therapy
#5
Paola Stefanelli, Maria Fenicia Vescio, Maria Paola Landini, Ivano Dal Conte, Alberto Matteelli, Antonio Cristaudo, Marina Gaino, Marco Cusini, Anna Maria Barbui, Antonella Mencacci, Rosella De Nittis, Valeria Ghisetti, Elena Stroppiana, Anna Carannante
INTRODUCTION: Neisseria gonorrhoeae (NG) antimicrobial susceptibility trends to azithromycin, cefixime and ceftriaxone were analyzed, from 2009 to 2016, to monitor changing antimicrobial susceptibility concomitant with the change in prescribing practice in 2012 from cefixime, or ceftriaxone, to ceftriaxone plus azithromycin. Patient characteristics predictive to be infected by antibiotic resistant N. gonorrhoeae were estimated. Finally, the protocol for the treatment of gonorrhoea, in comparison with the international guidelines, was also evaluated...
2017: PloS One
https://www.readbyqxmd.com/read/29240756/elastic-k-means-using-posterior-probability
#6
Aihua Zheng, Bo Jiang, Yan Li, Xuehan Zhang, Chris Ding
The widely used K-means clustering is a hard clustering algorithm. Here we propose a Elastic K-means clustering model (EKM) using posterior probability with soft capability where each data point can belong to multiple clusters fractionally and show the benefit of proposed Elastic K-means. Furthermore, in many applications, besides vector attributes information, pairwise relations (graph information) are also available. Thus we integrate EKM with Normalized Cut graph clustering into a single clustering formulation...
2017: PloS One
https://www.readbyqxmd.com/read/29240713/nb-based-zeolites-efficient-bi-functional-catalysts-for-the-one-pot-synthesis-of-succinic-acid-from-glucose
#7
Magdi El Fergani, Natalia Candu, Simona M Coman, Vasile I Parvulescu
The one-pot production of succinic acid from glucose was investigated in pure hot water as solvent using Nb (0.02 and 0.05 moles%)-Beta zeolites obtained by a post-synthesis methodology. Structurally, they are comprised of residual framework Al-acid sites, extra-framework isolated Nb (V) and Nb₂O₅ pore-encapsulated clusters. The Nb-modified Beta-zeolites acted as bi-functional catalysts in which glucose is dehydrated to levulinic acid (LA) which, further, suffers an oxidation process to succinic acid (SA)...
December 14, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29240687/decreasing-inappropriate-use-of-antibiotics-in-primary-care-in-four-countries-in-south-america-cluster-randomized-controlled-trial
#8
Inés Urbiztondo, Lars Bjerrum, Lidia Caballero, Miguel Angel Suarez, Monica Olinisky, Gloria Córdoba
High antibiotic prescribing and antimicrobial resistance in patients attending primary care have been reported in South America. Very few interventions targeting general practitioners (GPs) to decrease inappropriate antibiotic prescribing have been investigated in this region. This study assessed the effectiveness of online feedback on reducing antibiotic prescribing in patients with suspected respiratory tract infections (RTIs) attending primary care. The aim was to reduce antibiotic prescribing in patients with acute bronchitis and acute otitis media...
December 14, 2017: Antibiotics
https://www.readbyqxmd.com/read/29240520/draft-whole-genome-sequence-analyses-on-pseudomonas-syringae-pv-actinidiae-hr-negative-strains-detected-from-kiwifruit-bleeding-sap-samples
#9
Enrico Biondi, Alan Zamorano, Ernesto Vega, Stefano Ardizzi, Davide Sitta, Roberto De Salvador, Reinaldo Campos-Vargas, Claudio Meneses, Set Pérez, Assunta Bertaccini, Nicola Fiore
Kiwifruit bleeding sap samples, collected in Italian and Chilean orchards from symptomatic and asymptomatic plants, were evaluated for the presence of Pseudomonas syringae pv. actinidiae, the causal agent of bacterial canker. The saps were sampled during the spring of both hemispheres, before the bud sprouting, during the optimal time window for the collection of an adequate volume of sample for the early detection of the pathogen, preliminarily by molecular assays, and then, through its direct isolation and identification...
December 14, 2017: Phytopathology
https://www.readbyqxmd.com/read/29240516/association-between-duration-of-reproductive-years-and-metabolic-syndrome
#10
Yon Chul Park, Tae Sic Lee, Hee-Taik Kang, Eun Suk Cho, Jai Soon Kim, Yoo Jung Hwang, Jong-Koo Kim
BACKGROUND: The incidence of metabolic syndrome (MetS) has gradually increased in recent years. MetS has been associated with age at menarche and menopause; however, the association between MetS and the reproductive span remains unclear. MATERIALS AND METHODS: This study examined MetS and the reproductive span among 1,214 participants of the 2014 Korea National Health and Nutrition Examination Surveys, a stratified, complex, multistage, probability cluster survey conducted by the Division of Chronic Disease Surveillance of the Korea Center for Disease Control and Prevention since 1998...
December 14, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/29240428/structures-and-heats-of-formation-of-simple-alkaline-earth-metal-compounds-ii-fluorides-chlorides-oxides-and-hydroxides-for-ba-sr-and-ra
#11
Monica Vasiliu, J Grant Hill, Kirk A Peterson, David A Dixon
Geometry parameters, vibrational frequencies, heats of formation, bond dissociation energies, cohesive energies, and selected fluoride affinities (difluorides) are predicted for the late alkaline earth (Sr, Ba and Ra) oxides, fluorides, chlorides, and hydroxides at the coupled cluster theory [CCSD(T)] level. Additional corrections (scalar relativistic and pseudopotential corrections, vibrational zero-point energies, and atomic spin-orbit effects) were included to accurately calculate the total atomization energies and heats of formation following the Feller-Peterson-Dixon methodology...
December 14, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29240271/chromatin-level-regulation-of-the-fragmented-dothistromin-gene-cluster-in-the-forest-pathogen-dothistroma-septosporum
#12
Pranav Chettri, Pierre-Yves Dupont, Rosie E Bradshaw
Genes required for fungal secondary metabolite production are usually clustered, co-regulated and expressed in stationary growth phase. Chromatin modification has an important role in co-regulation of secondary metabolite genes. The virulence factor dothistromin, a relative of aflatoxin, provided a unique opportunity to study chromatin level regulation in a highly fragmented gene cluster that is switched on during early exponential growth phase. We analysed three histone modification marks by ChIP-qPCR and gene deletion in the pine pathogen Dothistroma septosporum to determine their effects on dothistromin gene expression across a time course and at different loci of the dispersed gene cluster...
December 14, 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/29240264/longitudinal-vitamin-d-deficiency-is-inversely-related-to-mite-sensitization-in-early-childhood
#13
Chih-Yung Chiu, Kuan-Wen Su, Ming-Han Tsai, Man-Chin Hua, Sui-Ling Liao, Shen-Hao Lai, Li-Chen Chen, Tsung-Chieh Yao, Kuo-Wei Yeh, Jing-Long Huang
BACKGROUND: There are few studies addressing the longitudinal analysis of vitamin D deficiency and its impact to the development of atopic diseases in early childhood. METHODS: We investigated 155 children who regularly followed up at our clinic for 5 years as subjects enrolled in a birth cohort study. The pattern of vitamin D levels from birth to 5 years of age was clustered using K-means method in R software. Absolute eosinophil count (AEC), total serum and specific immunoglobulin E antibodies against food (egg white, milk, and wheat) and inhalant allergens (D...
December 14, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29240263/cytochemical-flow-analysis-of-intracellular-g6pd-and-aggregate-analysis-of-mosaic-g6pd-expression
#14
Michael Kalnoky, Germana Bancone, Maria Kahn, Cindy S Chu, Nongnud Chowwiwat, Pornpimon Wilaisrisak, Sampa Pal, Nicole LaRue, Brandon Leader, Francois Nosten, Gonzalo J Domingo
BACKGROUND: Medicines that exert oxidative pressure on red blood cells (RBC) can cause severe hemolysis in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Due to X-chromosome inactivation, females heterozygous for G6PD with one allele encoding a G6PD deficient protein and the other a normal protein produce two RBC populations each expressing exclusively one allele. The G6PD mosaic is not captured with routine G6PD tests. METHODS: An open-source software tool for G6PD cytofluorometric data interpretation is described...
December 14, 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/29239819/lncrna-hoxd-as1-promotes-epithelial-ovarian-cancer-cells-proliferation-and-invasion-by-targeting-mir-133a-3p-and-activating-wnt-%C3%AE-catenin-signaling-pathway
#15
Ying Zhang, Yanbing Dun, Shumin Zhou, Xiang-Hua Huang
BACKGROUND: Long non-coding RNA (lncRNA) HOXD cluster antisense RNA 1 (HOXD-AS1) functions as a crucial regulator in the progression and development of tumors. The aim of this study is to unravel the underlying mechanisms of HOXD-AS1 on epithelial ovarian cancer (EOC). METHODS: 43 paired EOC tissues and adjacent non-tumor tissues were collected postoperatively from patients. QRT-PCR was used to explore HOXD-AS1 expression in both EOC tissues and cell lines. Cell proliferation and invasion were monitored by MTT assay and transwell invasion assay...
November 24, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29239777/a-content-review-of-online-naloxone-continuing-education-courses-for-pharmacists-in-states-with-standing-orders
#16
Delesha M Carpenter, Courtney A Roberts, Salisa C Westrick, Stefanie P Ferreri, Korey A Kennelty, Kevin A Look, Olufunmilola Abraham, Courtenay Wilson
BACKGROUND: Many community pharmacists are uncomfortable educating patients about naloxone, an opioid reversal agent. OBJECTIVE: To examine whether training materials prepare pharmacists to counsel patients and caregivers about naloxone, online naloxone education materials for pharmacists in the 13 states with standing orders were analyzed. METHODS: Two coders reviewed 12 naloxone training programs and extracted data for 15 topics that were clustered in four categories: background/importance, naloxone products, business/operations, and communication...
November 21, 2017: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/29239707/immigration-psychic-dislocation-and-the-re-creation-of-community
#17
Ricardo C Ainslie
Communities are "psychic entities" that serve powerful psychological functions for the individuals living within them. They also serve multiple functions, including as a potential space where individuals are "held" and within which individuals "play" in ways akin to Winnicott's formulations regarding how infants "use" the me-not-me zone of experiencing, the potential space created by the gap between symbiotic engagement and the maternal object, in a zone between desire for fusion and fear of disintegrating abandonment...
December 2017: Psychoanalytic Review
https://www.readbyqxmd.com/read/29239690/antibody-drug-conjugates-design-and-development-for-therapy-and-imaging-in-and-beyond-cancer-labex-mabimprove-industrial-workshop-july-27-28-2017-tours-france
#18
Camille Martin, Claire Kizlik-Masson, André Pèlegrin, Hervé Watier, Marie-Claude Viaud-Massuard, Nicolas Joubert
The annual "Antibody Industrial Symposium", co organized by LabEx MAbImprove, MabDesign and Polepharma, was held in Tours, France on June 27-28, 2017. The focus was on antibody-drug-conjugates (ADCs), new entities which realize the hope of Paul Ehrlich's magic bullet. ADCs result from the bioconjugation of a highly cytotoxic drug to a selective monoclonal antibody, which acts as a vector. Building on knowledge gained during the development of three approved ADCs, brentuximab vedotin (Adcetris®), ado trastuzumab emtansine (Kadcyla®) and inotuzumab ozogamicin (Besponsa®), and the many ADCs in development, this meeting addressed strategies and the latest innovations in the field from fundamental research to manufacturing...
December 14, 2017: MAbs
https://www.readbyqxmd.com/read/29239628/psychopathy-in-detained-boys-the-search-for-primary-and-secondary-variants-in-a-clinical-setting
#19
Olivier F Colins, Kostas A Fanti, Randall T Salekin, Eva Mulder, Henrik Andershed
This study investigates whether primary and secondary variants of psychopathy can be identified in an applied, forensic setting based on self-reports of psychopathy and anxiety. Data were available for two samples of detained boys (Sample A: N = 847, Sample B: N = 749). Using three psychopathy dimensions and anxiety as clustering variables, latent profile analysis arrived at 4 latent classes (LCs) that were tentatively labeled as control (LC1), high anxiety (LC2), moderate psychopathy (LC3), and high psychopathy (LC4)...
December 14, 2017: Personality Disorders
https://www.readbyqxmd.com/read/29239605/correction-to-suppressing-isomerization-of-phosphine-protected-au9-cluster-by-bond-stiffening-induced-by-a-single-pd-atom-substitution
#20
Seiji Yamazoe, Shota Matsuo, Satoru Muramatsu, Shinjiro Takano, Kiyofumi Nitta, Tatsuya Tsukuda
No abstract text is available yet for this article.
December 14, 2017: Inorganic Chemistry
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