keyword
https://read.qxmd.com/read/38537179/dispersion-control-over-molecule-cohesion-exploiting-and-dissecting-the-tipping-power-of-aromatic-rings
#1
JOURNAL ARTICLE
Ricardo A Mata, Tlektes Zhanabekova, Daniel A Obenchain, Martin A Suhm
ConspectusWe have learned over the past years how London dispersion forces can be effectively used to influence or even qualitatively tip the structure of aggregates and the conformation of single molecules. This happens despite the fact that single dispersion contacts are much weaker than competing polar forces. It is a classical case of strength by numbers, with the importance of London dispersion forces scaling with the system size. Knowledge about the tipping points, however difficult to attain, is necessary for a rational design of intermolecular forces...
March 27, 2024: Accounts of Chemical Research
https://read.qxmd.com/read/38537142/first-report-of-fusarium-falciforme-causing-root-and-rhizome-rot-of-epimedium-sagittatum-in-china
#2
JOURNAL ARTICLE
Leixia Chu, Diandian Li, Wenchuan Hou, Zhiwei Dan, Xiaojie Wang, Chengming Dong
Epimedium sagittatum (Sieb.et Zucc.) Maxim., a perennial herb, is an important medicinal plant, rich in flavonoids, and widely used in the treatment of sexual dysfunction, rheumatic disease, and cancers (Tan et al. 2016). In July 2022, a disease of root and rhizome was found on E. sagittatum aged 1-8 years in a planting area (266 ha) of Zhumadian City (32°58'12" N, 114°37'48" E), Henan Province, China. The disease incidence per field (660 m2 ) was around 10-15% in six randomly surveyed fields planted with about 10,000 E...
March 27, 2024: Plant Disease
https://read.qxmd.com/read/38537135/first-report-of-white-mucus-disease-caused-by-fuligo-gyrosa-on-agrocybe-chaxingu-in-china
#3
JOURNAL ARTICLE
Xutao Chen, Qing Liu, Guoliang Meng, Xinhong Peng, Caihong Dong, Yunhui Wei, Guanghua Huo
Agrocybe chaxingu is an edible and medicinal mushroom widely cultivated in China (Liu et al. 2021). Agrocybe chaxingu is extremely well-liked for the unique flavor and nutritional value. In May 2021, a serious white mucus disease was observed in the farms of A. chaxingu in the Ganxian district of Ganzhou City, Jiangxi Province, China, with an approximate disease incidence of 20%. In the years of 2022 and 2023, the same white mucus disease on A. chaxingu was observed in the farms in Nanchang City, Jiujiang City and Guangchang County, Jiangxi Province, China...
March 27, 2024: Plant Disease
https://read.qxmd.com/read/38537130/comprehensive-molecular-classification-predicted-microenvironment-profiles-and-therapy-response-for-hepatocellular-carcinoma
#4
JOURNAL ARTICLE
Yihong Chen, Xiangying Deng, Yin Li, Ying Han, Yinghui Peng, Wantao Wu, Xinwen Wang, Jiayao Ma, Erya Hu, Xin Zhou, Edward Shen, Shan Zeng, Changjing Cai, Yiming Qin, Hong Shen
BACKGROUND AND AIMS: Tumor microenvironment (TME) heterogeneity leads to a discrepancy in survival prognosis and clinical treatment response for hepatocellular carcinoma (HCC) patients. The clinical applications of documented molecular subtypes are constrained by several issues. APPROACH AND RESULTS: We integrated three single-cell datasets to describe the TME landscape and identified six prognosis-related cell subclusters. Unsupervised clustering of subcluster-specific markers was performed to generate transcriptomic subtypes...
March 27, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38537044/toxoplasmosis-outbreak-in-s%C3%A3-o-paulo-brazil-epidemiology-and-visual-outcome
#5
JOURNAL ARTICLE
Luciana Peixoto Santos Finamor, Geraldine Madalosso, José Eduardo Levi, Yuslay Fernández Zamora, Gabriela Akemi Kamioka, Paula Marinho, Heloisa Nascimento, Cristina Muccioli, Rubens Belfort
PURPOSE: To describe a 2019 acute toxoplasmosis outbreak in the city of São Paulo, Brazil, and to evaluate the laboratory serological profile for toxoplasmosis for three consecutive years. The ophthalmological manifestations of the patients involved in the outbreak were also studied. METHODS: A cross-sectional descriptive study of a toxoplasmosis outbreak in São Paulo, Brazil, between February and May 2019. Epidemiological data were described, as were the observed ocular manifestations...
2024: Arquivos Brasileiros de Oftalmologia
https://read.qxmd.com/read/38536936/multiple-sclerosis-endophenotypes-identified-by-high-dimensional-blood-signatures-are-associated-with-distinct-disease-trajectories
#6
JOURNAL ARTICLE
Catharina C Gross, Andreas Schulte-Mecklenbeck, Olga V Steinberg, Timo Wirth, Sarah Lauks, Stefan Bittner, Patrick Schindler, Sergio E Baranzini, Sergiu Groppa, Judith Bellmann-Strobl, Nora Bünger, Claudia Chien, Eva Dawin, Maria Eveslage, Vinzenz Fleischer, Gabriel Gonzalez-Escamilla, Barbara Gisevius, Jürgen Haas, Martin Kerschensteiner, Lucienne Kirstein, Catharina Korsukewitz, Lisa Lohmann, Jan D Lünemann, Felix Luessi, Gerd Meyer Zu Hörste, Jeremias Motte, Tobias Ruck, Klemens Ruprecht, Nicholas Schwab, Falk Steffen, Sven G Meuth, Friedemann Paul, Brigitte Wildemann, Tania Kümpfel, Ralf Gold, Tim Hahn, Frauke Zipp, Luisa Klotz, Heinz Wiendl
One of the biggest challenges in managing multiple sclerosis is the heterogeneity of clinical manifestations and progression trajectories. It still remains to be elucidated whether this heterogeneity is reflected by discrete immune signatures in the blood as a surrogate of disease pathophysiology. Accordingly, individualized treatment selection based on immunobiological principles is still not feasible. Using two independent multicentric longitudinal cohorts of patients with early multiple sclerosis ( n = 309 discovery and n = 232 validation), we were able to identify three distinct peripheral blood immunological endophenotypes by a combination of high-dimensional flow cytometry and serum proteomics, followed by unsupervised clustering...
March 27, 2024: Science Translational Medicine
https://read.qxmd.com/read/38536875/investigating-hill-sheep-farmers-and-crofters-experiences-of-blackloss-in-the-highlands-and-islands-of-scotland
#7
JOURNAL ARTICLE
Fiona McAuliffe, Ann McLaren, Neil Sargison, Franz Brülisauer, Andrew Kent, Davy McCracken
Hill sheep farming is an important component of Scottish agriculture and comprises a significant land use in much of the Highlands and Islands. However it faces significant challenges due to the natural constraints of the landscape. Hill sheep farming uses hardy traditional breeds, such as the Scottish blackface and North Country Cheviot to graze extensive areas, where the sheep are not housed and tend to lamb on the open hill. Flocks are gathered several times a year for stock checks, husbandry, and health treatments...
2024: PloS One
https://read.qxmd.com/read/38536857/investigating-the-relationship-between-microbial-network-features-of-giant-kelp-seedbank-cultures-and-subsequent-farm-performance
#8
JOURNAL ARTICLE
Melisa G Osborne, Ariel Levi Simons, Gary Molano, Bernadeth Tolentino, Anupam Singh, Gabriel J Montecinos Arismendi, Filipe Alberto, Sergey V Nuzhdin
Microbial inoculants can increase the yield of cultivated crops and are successful in independent trials; however, efficacy drops in large-scale applications due to insufficient consideration of microbial community dynamics. The structure of microbiomes, in addition to the impact of individual taxa, is an important factor to consider when designing growth-promoting inoculants. Here, we investigate the microbial network and community assembly patterns of Macrocystis pyrifera gametophyte germplasm cultures (collectively referred to as a "seedbank") used to cultivate an offshore farm in Santa Barbara, California, and identify network features associated with increased biomass of mature sporophytes...
2024: PloS One
https://read.qxmd.com/read/38536822/immediate-postnatal-prediction-of-death-or-bronchopulmonary-dysplasia-among-very-preterm-and-very-low-birth-weight-infants-based-on-gradient-boosting-decision-trees-algorithm-a-nationwide-database-study-in-japan
#9
JOURNAL ARTICLE
Kota Yoneda, Tomohisa Seki, Yoshimasa Kawazoe, Kazuhiko Ohe, Naoto Takahashi
INTRODUCTION: Bronchopulmonary dysplasia (BPD) poses a substantial global health burden. Individualized treatment strategies based on early prediction of the development of BPD can mitigate preterm birth complications; however, previously suggested predictive models lack early postnatal applicability. We aimed to develop predictive models for BPD and mortality based on immediate postnatal clinical data. METHODS: Clinical information on very preterm and very low birth weight infants born between 2008 and 2018 was extracted from a nationwide Japanese database...
2024: PloS One
https://read.qxmd.com/read/38536809/enhanced-dietary-reconstruction-of-korean-prehistoric-populations-by-combining-%C3%AE-13c-and-%C3%AE-15n-amino-acids-of-bone-collagen
#10
JOURNAL ARTICLE
Kyungcheol Choy, Hee Young Yun, Benjamin T Fuller, Marcello A Mannino
Compound specific stable isotope analysis of amino acids (CSIA-AA) is a powerful tool for determining dietary behaviors in complex environments and improving dietary reconstructions. Here, we conducted CSIA-AA on human (n = 32) and animal (n = 13) remains from two prehistoric archaeological sites (Mumun, Imdang) to assess in more detail the dietary sources consumed by prehistoric Korean populations. Results of estimated trophic position (TP) using Δ15NGlx-Phe show that the Imdang individuals consumed aquatic resources, as well as terrestrial resources...
2024: PloS One
https://read.qxmd.com/read/38536794/observed-instagram-use-and-satisfaction-with-life-associations-with-received-communications-and-exploration-of-others-content-after-posting-a-selfie
#11
JOURNAL ARTICLE
Kyla M Cary, Megan K Maas, Kirsten M Greer, Dar Meshi
Over 70% of Americans use social media platforms, like Instagram. With this high prevalence, researchers have investigated the relationship between social media use and psychological well-being. Extant research has yielded mixed results, however, as most measures of social media use are self-reported and focus on amount of use. Even when studies account for type of social media use, such as active or passive use, there remains much to be captured. To address this, we asked participants to report their satisfaction with life and then recorded their actual Instagram activity for 10 minutes after posting a "selfie" portrait to their account...
2024: PloS One
https://read.qxmd.com/read/38536724/in-silico-methods-for-immunogenicity-risk-assessment-and-human-homology-screening-for-therapeutic-antibodies
#12
JOURNAL ARTICLE
Aimee E Mattei, Andres H Gutierrez, Soorya Seshadri, Jacob Tivin, Matt Ardito, Amy S Rosenberg, William D Martin, Anne S De Groot
In silico immunogenicity risk assessment has been an important step in the development path for many biologic therapeutics, including monoclonal antibodies. Even if the source of a given biologic is 'fully human', T cell epitopes that are contained in the sequences of the biologic may activate the immune system, enabling the development of anti-drug antibodies that can reduce drug efficacy and may contribute to adverse events. Computational tools that identify T cell epitopes from primary amino acid sequences have been used to assess the immunogenic potential of therapeutic candidates for several decades...
2024: MAbs
https://read.qxmd.com/read/38536704/networks-of-hydrogen-bond-networks-in-water-clusters
#13
JOURNAL ARTICLE
Andrey M Tokmachev
Water clusters play a prominent role in atmospheric and solution chemistry. Numerous arrangements of protons, H-bond configurations or networks, shape the cluster properties. Studies of small water clusters by cryogenic scanning tunneling microscopy and high-resolution rovibrational spectroscopy have established proton rearrangement mechanisms forming pathways between H-bond networks. The mechanisms, concerted tunneling in particular, describe the local processes connecting pairs of configurations. Here, proton rearrangement networks mapping these transformations are defined and explored to provide a global view of the H-bond configurations in clusters...
March 27, 2024: Journal of Physical Chemistry. A
https://read.qxmd.com/read/38536682/weakly-supervised-contrastive-learning-for-unsupervised-object-discovery
#14
JOURNAL ARTICLE
Yunqiu Lv, Jing Zhang, Nick Barnes, Yuchao Dai
Unsupervised object discovery (UOD) refers to the task of discriminating the whole region of objects from the background within a scene without relying on labeled datasets, which benefits the task of bounding-box-level localization and pixel-level segmentation. This task is promising due to its ability to discover objects in a generic manner. We roughly categorize existing techniques into two main directions, namely the generative solutions based on image resynthesis, and the clustering methods based on self-supervised models...
March 27, 2024: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://read.qxmd.com/read/38536633/the-significance-of-m6a-rna-methylation-regulators-in-diagnosis-and-subtype-classification-of-hbv-related-hepatocellular-carcinoma
#15
JOURNAL ARTICLE
Qijuan Zang, Yalin Ju, Siyi Liu, Shaobo Wu, Chengbin Zhu, Liangru Liu, Weicheng Xu, Yingli He
In recent years, abnormal m6A alteration in hepatocellular carcinoma (HCC) has been a focus on investigating the biological implications. In this study, our objective is to determine whether m6A modification contributes to the progression of HBV-related HCC. To achieve this, we employed a random forest model to screen top 8 characteristic m6A regulators from 19 candidate genes. Subsequently, we developed a nomogram model that utilizes these 8 characteristic m6A regulators to predict the prevalence of HBV-related HCC...
March 27, 2024: Human Cell
https://read.qxmd.com/read/38536572/ecological-river-health-assessments-based-on-fish-ordination-analysis-of-ecological-indicator-entities-and-the-biological-integrity-metrics-responding-to-the-chemical-water-pollution
#16
JOURNAL ARTICLE
Namsrai Jargal, Jeong-Eun Kim, Bilguun Ariunbold, Kwang-Guk An
Evaluation of the ecological health of rivers requires a focused examination of how biological indicators respond to chemical stressors to offer key insights for effective conservation strategies. We examined the influence of stressors on aquatic ecosystems by analyzing various ecological entities and biotic integrity metrics of fish communities. A nonmetric multidimensional scaling (NMDS) approach was applied to determine scores based on 19 fish ecological entities (FEs) and a fish-based multi-metric index of biotic integrity (mIBI-F)...
March 27, 2024: Environmental Science and Pollution Research International
https://read.qxmd.com/read/38536568/integration-of-single-cell-and-bulk-rna-seq-data-to-identify-the-cancer-associated-fibroblast-subtypes-and-risk-model-in-glioma
#17
JOURNAL ARTICLE
Xiuwei Yan, Xin Gao, Jiawei Dong, Fang Wang, Xiaoyan Jiang, Xueyan Hu, Jiheng Zhang, Nan Wang, Lei Xu, Zhihui Liu, Shaoshan Hu, Hongtao Zhao
Cancer-associated fibroblasts (CAFs) are an important component of the stroma. Studies showed that CAFs were pivotally in glioma progression which have long been considered a promising therapeutic target. Therefore, the identification of prognostic CAF markers might facilitate the development of novel diagnostic and therapeutic approaches. A total of 1333 glioma samples were obtained from the TCGA and CGGA datasets. The EPIC, MCP-counter, and xCell algorithms were used to evaluate the relative proportion of CAFs in glioma...
March 27, 2024: Biochemical Genetics
https://read.qxmd.com/read/38536537/correction-a-hybrid-pragmatic-and-factorial-cluster-randomized-controlled-trial-for-an-anti-racist-multilevel-intervention-to-improve-mental-health-equity-in-high-schools
#18
Marta I Mulawa, Sharron L Docherty, Donald E Bailey, Rosa M Gonzalez-Guarda, Isaac M Lipkus, Schenita D Randolph, Qing Yang, Wei Pan
No abstract text is available yet for this article.
March 27, 2024: Prevention Science: the Official Journal of the Society for Prevention Research
https://read.qxmd.com/read/38536504/intraspecific-niche-models-for-the-invasive-ambrosia-beetle-xylosandrus-crassiusculus-suggest-contrasted-responses-to-climate-change
#19
JOURNAL ARTICLE
T Urvois, M-A Auger-Rozenberg, A Roques, C Kerdelhué, J-P Rossi
Xylosandrus crassiusculus is an invasive ambrosia beetle comprising two differentiated genetic lineages, named cluster 1 and cluster 2. These lineages invaded different parts of the world at different periods of time. We tested whether they exhibited different climatic niches using Schoener's D and Hellinger's I indices and modeled their current potential geographical ranges using the Maxent algorithm. The resulting models were projected according to future and recent past climate datasets for Europe and the Mediterranean region...
March 27, 2024: Oecologia
https://read.qxmd.com/read/38536216/virulence-genes-resistome-and-mobilome-of-streptococcus-suis-strains-isolated-in-france
#20
JOURNAL ARTICLE
Manon Dechêne-Tempier, Claire de Boisséson, Pierrick Lucas, Stéphanie Bougeard, Virginie Libante, Corinne Marois-Créhan, Sophie Payot
Streptococcus suis is a leading cause of infection in pigs, causing extensive economic losses. In addition, it can also infect wild fauna, and can be responsible for severe infections in humans. Increasing antimicrobial resistance (AMR) has been described in S. suis worldwide and most of the AMR genes are carried by mobile genetic elements (MGEs). This contributes to their dissemination by horizontal gene transfer. A collection of 102 strains isolated from humans, pigs and wild boars in France was subjected to whole genome sequencing in order to: (i) study their genetic diversity, (ii) evaluate their content in virulence-associated genes, (iii) decipher the mechanisms responsible for their AMR and their association with MGEs, and (iv) study their ability to acquire extracellular DNA by natural transformation...
March 2024: Microbial Genomics
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