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João Victor Salgado, Izabel Athayde da Silva Cruz Salgado, Leônidas Lopes Braga Júnior, Silane Calland Marques Serra, Verbena Maria de Carvalho Barros, Maria José Alves Silva, Valério Monteiro-Neto
Neuroschistosomiasis is a severe disease caused by the presence of Schistosoma eggs and/or adult worms in the central nervous system. Schistosomal transverse myelitis represents a rare clinical form with nonspecific clinical findings, and it is thus underdiagnosed, especially in children. In this report, we describe a 6-year-old patient with the myeloradicular form of neuroschistosomiasis.
December 2015: Pediatric Infectious Disease Journal
Chandy C John, Hélène Carabin, Silvia M Montano, Paul Bangirana, Joseph R Zunt, Phillip K Peterson
Infections that cause significant nervous system morbidity globally include viral (for example, HIV, rabies, Japanese encephalitis virus, herpes simplex virus, varicella zoster virus, cytomegalovirus, dengue virus and chikungunya virus), bacterial (for example, tuberculosis, syphilis, bacterial meningitis and sepsis), fungal (for example, cryptococcal meningitis) and parasitic (for example, malaria, neurocysticercosis, neuroschistosomiasis and soil-transmitted helminths) infections. The neurological, cognitive, behavioural or mental health problems caused by the infections probably affect millions of children and adults in low- and middle-income countries...
November 19, 2015: Nature
José Roberto Lambertucci, Thiago André Fidelis, Thiago Almeida Pereira, Paulo Marcos Zech Coelho, Neuza Araujo, Márcia Maria de Souza, Geraldo Brasileiro Filho, Fausto Edmundo Lima Pereira, Carlos Mauricio Antunes
INTRODUCTION: Human neuroschistosomiasis has been reported in the literature, but the possibility of modeling neuroschistosomiasis in mice is controversial. METHODS: In two research laboratories in Brazil that maintain the Schistosoma mansoni life cycle in rodents, two mice developed signs of brain disease (hemiplegia and spinning), and both were autopsied. RESULTS: S. mansoni eggs, both with and without granuloma formation, were observed in the brain and meninges of both mice by optical microscopy...
March 2014: Revista da Sociedade Brasileira de Medicina Tropical
José Roberto Lambertucci, Thiago André Fidelis, Thiago Almeida Pereira, Paulo Marcos Zech Coelho, Neuza Araujo, Márcia Maria de Souza, Geraldo Brasileiro, Fausto Edmundo Lima Pereira, Carlos Mauricio Antunes
Introduction Human neuroschistosomiasis has been reported in the literature, but the possibility of modeling neuroschistosomiasis in mice is controversial. Methods In two research laboratories in Brazil that maintain the Schistosoma mansoni life cycle in rodents, two mice developed signs of brain disease (hemiplegia and spinning), and both were autopsied. Results S. mansoni eggs, both with and without granuloma formation, were observed in the brain and meninges of both mice by optical microscopy. Conclusions This is the first description of eggs in the brains of symptomatic mice that were experimentally infected with S...
February 12, 2014: Revista da Sociedade Brasileira de Medicina Tropical
Georg Härter, Hagen Frickmann, Sebastian Zenk, Dominic Wichmann, Bettina Ammann, Peter Kern, Bernhard Fleischer, Egbert Tannich, Sven Poppert
We describe the case of a 16-year-old German male expatriate from Ghana who presented with obstipation, dysuria, dysaesthesia of the gluteal region and the lower limbs, bilateral plantar hypaesthesia and paraesthesia without pareses. A serum-cerebrospinal fluid (CSF) Schistosoma spp. specific antibody specificity index of 3.1 was considered highly suggestive of intrathecal synthesis of anti-Schistosoma spp. specific antibodies, although standardization of this procedure has not previously been described. Diagnosis was confirmed by detection of Schistosoma DNA in CSF by semi-quantitative real-time PCR at 100-fold concentration compared with serum...
February 2014: Journal of Medical Microbiology
Ronaldo Abraham
The consequences of inflammatory response are primarily responsible for morbimortality in bacterial meningitis. Early use of steroids in these cases can reduce mortality and hearing loss and improve functional outcome without causing significant side effects. The formal recommendation towards pneumoccocal meningitis is being extended to other forms of Bacterial Meningitis. The same thought can be applied to tuberculous meningitis. In neurocysticercosis and neuroschistosomiasis steroids are more useful than parasiticides in most cases...
September 2013: Arquivos de Neuro-psiquiatria
Otávio Augusto Moreno de Carvalho
Mansonic neuroschistosomiasis (MN) is not only the most common but also the most serious ectopic presentation of the infection by Schistosoma mansoni. Both, brain and spinal cord can be independently affected by the infection, but the later is more frequently affected. Brain MN by itself is due to the presence of eggs and/or adult worms in situ and can be symptomatic or asymptomatic. Unlike the brain MN, spinal cord mansonic neuroschistosomiasis is more frequently symptomatic. In both forms the intensity, the seriousness and also the clinical characteristics of signs and symptoms depend on the amount of eggs in the compromised region and on the intensity of the inflammatory reaction surrounding the eggs...
September 2013: Arquivos de Neuro-psiquiatria
Olga Mikulich, Elijah Chaila, Jim Maurice Crotty, Michael Watts
No abstract text is available yet for this article.
2013: BMJ Case Reports
Omar I Jaber, Patricia A Kirby
OBJECTIVES: To report a case of a US resident, originally from Liberia, with chronic hepatitis C infection who developed acute neurologic symptoms of the lower limbs. METHODS: Our case is compared to previously reported similar cases, with emphasis on clinical symptoms, investigations, diagnosis, and prognosis. RESULTS: The patient was transferred to the University of Iowa Hospital and Clinics for further management of severe retroperitoneal bleeding and died 2 days after admission...
July 2013: American Journal of Clinical Pathology
Luciane Mota Lima, Silvane Braga Santos, Ricardo Riccio Oliveira, Luciana Santos Cardoso, Sérgio Costa Oliveira, Alfredo Miranda Góes, Alex Loukas, Edgar M Carvalho, Maria Ilma Araújo
UNLABELLED: Human T cell lymphotropic virus type 1 (HTLV-1) is the causal agent of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). While the immune response to HTLV-1 infection is polarized to the Th1-type, chronic helminth infections drive the Th2- and T regulatory-type, and are able to downregulate the inflammatory response in some autoimmune diseases. OBJECTIVE: To evaluate whether Schistosoma spp. antigens alter the in vitro cytokine response in HTLV-1 infection...
2013: Neuroimmunomodulation
Thiago Cardoso Vale, Sílvio Roberto de Sousa-Pereira, José Roberto Lambertucci
No abstract text is available yet for this article.
March 2013: Revista da Sociedade Brasileira de Medicina Tropical
Jia Xu, Xiao-Jie Lu, Dan Wang, Ming-Can Wu, Shi-Jie Chen, Jun-Chuan Li, Peng Wang
OBJECTIVE: To establish an experimental model of neuroschistosomiasis and investigate the model establishment factors. METHODS: Rabbits were used for the animal model and Schistosoma japonicum eggs (1 mg/ml) were directly injected into the brain by two ways of a bone drill or needle. The symptoms were observed and in the first and second week and later, the rabbits' brains were removed for pathological examinations. RESULTS: One to two weeks after the injection of schistosome eggs, the rabbits had various neurological symptoms such as loss of appetite, hemiparesis, seizure, etc...
February 2013: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
Cecilia Szekeres, Philippe Galletout, Stéphane Jaureguiberry, Etienne Crickx, Gentiane Monsel, Hugues Chabriat, Eric Jouvent
No abstract text is available yet for this article.
May 18, 2013: Lancet
Eyal Meltzer, Eli Schwartz
Schistosomiasis is increasingly encountered among travelers returning from the tropics, mainly from Africa. Schistosoma-infected travelers have served as sentinels for the existence of unknown foci of transmission even outside Africa. Acute schistosomiasis (also termed Katayama syndrome) is the common manifestation among travelers and may follow exposure to any of the Schistosoma species. Neuroschistosomiasis is a rare complication but may result in severe disability. Diagnosis in travelers is hampered by the poor sensitivity of microscopy in urine and stool, especially during acute infections, while seroconversion may be delayed for a period of weeks...
June 2013: Current Infectious Disease Reports
Thiago C Vale, Sílvio R de Sousa-Pereira, João G R Ribas, José R Lambertucci
BACKGROUND: Schistosomiasis is a tropical disease caused by worms of the genus Schistosoma. It is endemic in the Caribbean Islands, the middle east, eastern Asia, South America, and Africa. In nonendemic areas, physicians should be aware of this condition in travelers returning from endemic areas and in immigrants. The main disease-causing species are Schistosoma haematobium, Schistosoma mansoni, and Schistosoma japonicum. Neuroschistosomiasis is an ectopic form of the disease that is mainly associated with S...
November 2012: Neurologist
Francisco Javier Carod Artal
Cerebral schistosomiasis and spinal schistosomiasis are severe underrecognized complications of Schistosoma sp. infection, and can occur at any time during the parasitic infection. Neuroschistosomiasis has been increasingly reported not only in endemic areas but also in Western countries owing to immigration and international travel. Immunogenic interaction between schistosome egg deposition and the delayed hypersensitivity reaction of the host are the main neuropathogenic mechanisms involved. Eggs induce a periovular granulomatous reaction in the tissues...
December 2012: Current Neurology and Neuroscience Reports
F A Cisse, Y Morel, M A Bangoura, A Jedou, A Basse, M Ndiaye, A G Diop, M M Ndiaye, A Cisse
INTRODUCTION: Neurological complications of schistosomiasis remain exceptional even in hyperendemic area. CASE REPORT: We report a 26-year-old Senegalese man, without past medical history, who was admitted for spastic paraplegia, acute retention of urine, and pain in low back and lower limbs. The final diagnosis was spinal cord schistosomiasis. Diagnosis was based on the endemic context, MRI medullar conus imaging, schistosoma serology in cerebrospinal fluid and blood, and the absence of other cause of myelopathy...
October 2012: La Revue de Médecine Interne
Patrícia Pita Lobo, Miguel Coelho, Ruth Geraldes, Carolina Santos, Maria Grácio, Mário Miguel Rosa, João Lobo Antunes
Neuroschistosomiasis caused by Schistosoma mansoni (Sm) is a rare and severe condition potentially leading to permanent neurological deficit. An 18-year-old Brazilian female was admitted due to a severe conus medullaris and cauda equina syndrome. MRI of thoracic/lumbar spine showed an expanded conus medullaris with patchy gadolinium-enhancement, needle electromyography revealed acute bilateral radiculopathy (L5-S1-S2), cerebrospinal fluid (CSF) showed lymphocytosis and increased proteins and lesion' surgical biopsy documented a lymphocyte infiltrate...
2011: BMJ Case Reports
A D Salim, M A Arbab, L A El Hassan, M El Hassan
Schistosomiasis of the spinal cord is an uncommon but potentially curable form of schistosomiasis, if diagnosed and managed early. The spinal cord is more frequently affected in Schistosoma mansoni or S. haematobium infections. This paper describes the clinical manifestations, diagnosis and management of schistosomiasis of the spinal cord in 5 patients attending Shaab and Ibn Khuldoun Hospitals, Khartoum from 1997 to 2007. There were 4 males and 1 female aged 9-45 years. They presented with symptoms and signs due to cord compression at the lower thoracic and lumbar vertebrae...
March 2012: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
Claudio Henrique Fernandes Vidal, Maria Lucia Brito Ferreira, Hildo Rocha Cirne de Azevedo Filho, Fernando Viana Gurgel, Alessandra Mertens Brainer-Lima
UNLABELLED: The diagnosis of schistosomal myelitis (SM) is frequently presumptive because no findings from any complementary examination are pathognomonic for this disease. The present report describes some abnormalities seen on magnetic resonance imaging (MRI) evaluation of a series of SM patients and discusses their etiopathogenesis. METHODS: This study evaluated SM patients at the time of their diagnosis. These patients routinely underwent MRI on all segments of the spinal cord...
March 2012: Arquivos de Neuro-psiquiatria
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