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JOURNAL ARTICLE
Rafael San-Juan, Julia Origuen, Karen Campion, Mario Fernández-Ruiz, Beatriz Diaz-Pollan, Alejandro Callejas-Diaz, Giancarlo Candela, Maria Angeles Orellana, David Lora, Irene Llorente Muñoz, Maria Teresa Garcia, Maite Martinez-Uña, Jose Miguel Ferrari, Jose M Aguado
INTRODUCTION: Clostridioides difficile infection (CDI) is the most prevalent cause of nosocomial bacterial diarrhoea and it is strongly associated with antibiotic use. The recurrence of CDI is a growing medical problem. Data from real-life studies and one open label randomised clinical trial (RCT) suggest that secondary prophylaxis with oral vancomycin (SPV) during subsequent courses of systemic antibiotics is a promising approach for reducing the risk of CDI recurrence. Our aim is to confirm the role of SPV through a double-blind RCT...
September 13, 2023: BMJ Open
#22
JOURNAL ARTICLE
Lilian Martins Oliveira Diniz, Jesiana Ferreira Pedrosa, Pedro Pires Pimenta, Luynne Lana Monteiro, Rafael Arantes Oliveira, André Vinícius Soares Barbosa, Joziele de Souza Lima, Bruna Campos Cardoso Vilela, Livya Isabella Teles de Oliveira Lima, Ana Laura Moreira Teixeira, Teresa Cristina de Abreu Ferrari
No abstract text is available yet for this article.
October 1, 2022: Pediatric Infectious Disease Journal
#23
JOURNAL ARTICLE
Tommaso Filippini, Teresa Urbano, Peter Grill, Carlotta Malagoli, Angela Ferrari, Cristina Marchesi, Nicoletta Natalini, Bernhard Michalke, Marco Vinceti
INTRODUCTION: Selenium (Se) is a trace element with different toxicological and nutritional properties according to its chemical forms. Among the wide range of selenium species, human serum albumin-bound selenium (Se-HSA) has still uncertain composition in terms of organic or inorganic selenium species. This study aimed at investigating the relation between Se-HSA levels with total selenium and the specific organic and inorganic selenium species. METHODS: We determined levels of total selenium and selenium species in serum of participants enrolled in two populations of the Emilia-Romagna region, in Northern Italy...
July 22, 2023: Journal of Trace Elements in Medicine and Biology
#24
JOURNAL ARTICLE
Gioia Marino, Federica Campanelli, Giuseppina Natale, Maria De Carluccio, Federica Servillo, Elena Ferrari, Fabrizio Gardoni, Maria Emiliana Caristo, Barbara Picconi, Antonella Cardinale, Vittorio Loffredo, Francesco Crupi, Elvira De Leonibus, Maria Teresa Viscomi, Veronica Ghiglieri, Paolo Calabresi
Intensive physical activity improves motor functions in patients with Parkinson's disease (PD) at early stages. However, the mechanisms underlying the beneficial effects of exercise on PD-associated neuronal alterations have not been fully clarified yet. Here, we tested the hypothesis that an intensive treadmill training program rescues alterations in striatal plasticity and early motor and cognitive deficits in rats receiving an intrastriatal injection of alpha-synuclein (α-syn) preformed fibrils. Improved motor control and visuospatial learning in active animals were associated with a recovery of dendritic spine density alterations and a lasting rescue of a physiological corticostriatal long-term potentiation (LTP)...
July 14, 2023: Science Advances
#25
JOURNAL ARTICLE
Laura Mazzera, Manuela Abeltino, Guerino Lombardi, Anna Maria Cantoni, Stefano Jottini, Attilio Corradi, Micaela Ricca, Elena Rossetti, Federico Armando, Angelo Peli, Anna Ferrari, Giovanni Martinelli, Maria Teresa Scupoli, Carlo Visco, Massimiliano Bonifacio, Alessia Ripamonti, Carlo Gambacorti-Passerini, Antonio Bonati, Roberto Perris, Paolo Lunghi
Resistance to tyrosine kinase inhibitors (TKIs) remains a clinical challenge in Ph-positive variants of chronic myeloid leukemia. We provide mechanistic insights into a previously undisclosed MEK1/2/BCR::ABL1/BCR/ABL1-driven signaling loop that may determine the efficacy of arsenic trioxide (ATO) in TKI-resistant leukemic patients. We find that activated MEK1/2 assemble into a pentameric complex with BCR::ABL1, BCR and ABL1 to induce phosphorylation of BCR and BCR::ABL1 at Tyr360 and Tyr177, and ABL1, at Thr735 and Tyr412 residues thus provoking loss of BCR's tumor-suppression functions, enhanced oncogenic activity of BCR::ABL1, cytoplasmic retention of ABL1 and consequently drug resistance...
June 29, 2023: Leukemia
#26
JOURNAL ARTICLE
Milena Trentinaglia, Alessandro Dinoto, Sara Carta, Vanessa Chiodega, Sergio Ferrari, Vincenzo Andreone, Giorgia Teresa Maniscalco, Sara Mariotto
INTRODUCTION: The association of myelin oligodendrocyte glycoprotein (MOG) antibody associated disease (MOGAD) and tumors has seldom been reported. We aim to investigate the occurrence of tumors in a cohort of patients with MOGAD and to describe their clinical features, in addition to previously reported cases. METHODS: We retrospectively identified patients with MOGAD (i.e., compatible clinical phenotype and positive MOG antibodies analysed with a live cell-based assay) from 1/1/2015 to 1/1/2023 who had a neoplasm diagnosed within 2 years from MOGAD onset...
2023: Frontiers in Neurology
#27
JOURNAL ARTICLE
Luciana Carneiro Pena, Cláudia Alves Couto, Bernardo Henrique Mendes Correa, Luisa Fabiana Queiroz Ferrua, Guilherme Grossi Lopes Cançado, Luciana Costa Faria, Eliane Viana Mancuzo, Teresa Cristina Abreu Ferrari
INTRODUCTION: Non-alcoholic fatty liver disease (NAFLD) is related to cardiovascular disease. Cardiorespiratory fitness (CRF) is an important indicator of cardiovascular health. Therefore, we aimed to evaluate the CRF of NAFLD patients. METHODS: Cross-sectional study, including 32 patients with biopsy-proved NAFLD. The patients underwent ergometric test (ET) and six-minute walk test (6MWT) to determine CRF. The test results were compared to disease parameters and with each other...
June 16, 2023: Clinics and Research in Hepatology and Gastroenterology
#28
JOURNAL ARTICLE
Giulia Zucchetti, Paola Quarello, Andrea Ferrari, Matteo Silva, Federico Mercolini, Pierpaolo Sciarra, Antonella Guido, Laura Peruzzi, Paolo Colavero, Maria Montanaro, Rino Taormina, Maria V Micheletti, Federica Solari, Teresa Perillo, Anna Paioli, Monica Canepa, Camilla Migliozzi, Livia Zuliani, Valentina Solfa, Marina Bertolotti, Franca Fagioli
PURPOSE: This study set out to evaluate the psychosocial effects of coronavirus disease 2019 (COVID-19) among adolescents with cancer, and whether these effects are significantly different among adolescents who were undergoing therapy or had completed it. MATERIALS AND METHODS: The AIEOP Adolescents Working Group and the AIEOP Psychosocial Working Group adapted a questionnaire, which was completed by 214 adolescent cancer patients (Mage=16.3 y, range: 15 to 19 y old) treated at 16 AIEOP centers in the North (38%), South (31%), and Center (31%) of Italy...
June 5, 2023: Journal of Pediatric Hematology/oncology
#29
JOURNAL ARTICLE
Neena Roy, Clara Lazzaretti, Elia Paradiso, Chiara Capponi, Tommaso Ferrari, Francesca Reggianini, Samantha Sperduti, Lara Baschieri, Elisa Mascolo, Carmela Perri, Manuela Varani, Giulia Canu, Tommaso Trenti, Alessia Nicoli, Daria Morini, Francesca Iannotti, Maria Teresa Villani, Elena Vicini, Manuela Simoni, Livio Casarini
Bisphenol A (BPA) is a ubiquitous, synthetic chemical proven to induce reproductive disorders in both men and women. The available studies investigated the effects of BPA on male and female steroidogenesis following long-term exposure to the compound at relatively high environmental concentrations. However, the impact of short-term exposure to BPA on reproduction is poorly studied. We evaluated if 8 and 24 h exposure to 1 nM and 1 µM BPA perturbs luteinizing hormone/choriogonadotropin (LH/hCG)-mediated signalling in two steroidogenic cell models, i...
June 2, 2023: Cells
#30
JOURNAL ARTICLE
Raghav T Bhatia, Aneil Malhotra, Hamish MacLachlan, Sabiha Gati, Sarandeep Marwaha, Nikhil Chatrath, Saad Fyyaz, Haroldo Aleixo, Samar Al-Turaihi, Aswin Babu, Joyee Basu, Paul Catterson, Robert Cooper, Joelle J N Daems, Harshil Dhutia, Filipe Ferrari, Juliette C van Hattum, Zafar Iqbal, Alexandros Kasiakogias, Antoinette Kenny, Tamim Khanbhai, Shafik Khoury, Chris Miles, David Oxborough, Kashif Quazi, Dhrubo Rakhit, Anushka Sharma, Amanda Varnava, Maria Teresa Tome Esteban, Gherardo Finocchiaro, Ricardo Stein, Harald T Jorstad, Michael Papadakis, Sanjay Sharma
BACKGROUND AND AIM: The efficacy of pre-COVID-19 and post-COVID-19 infection 12-lead ECGs for identifying athletes with myopericarditis has never been reported. We aimed to assess the prevalence and significance of de-novo ECG changes following COVID-19 infection. METHODS: In this multicentre observational study, between March 2020 and May 2022, we evaluated consecutive athletes with COVID-19 infection. Athletes exhibiting de-novo ECG changes underwent cardiovascular magnetic resonance (CMR) scans...
March 27, 2023: Heart
#31
JOURNAL ARTICLE
Laura Lorenzon, Riccardo Caccialanza, Valentina Casalone, Gloria Santoro, Paolo Delrio, Francesco Izzo, Marco Tonello, Maria Cristina Mele, Carmelo Pozzo, Paolo Pedrazzoli, Andrea Pietrabissa, Piero Fenu, Alfredo Mellano, Elisabetta Fenocchio, Antonio Avallone, Francesca Bergamo, Maria Teresa Nardi, Roberto Persiani, Alberto Biondi, Flavio Tirelli, Annamaria Agnes, Renato Ferraris, Virginia Quarà, Michela Milanesio, Dario Ribero, Marilena Rinaldi, Paola D'Elia, Maurizio Rho, Carola Cenzi, Domenico D'Ugo
BACKGROUND: Mini-invasive surgery (MIS), ERAS, and preoperative nutritional screening are currently used to reduce complications and the length of hospital stay (LOS); however, inter-variable correlations have seldom been explored. This research aimed to define inter-variable correlations in a large series of patients with gastrointestinal cancer and their impact on outcomes. METHODS: Patients with consecutive cancer who underwent radical gastrointestinal surgery between 2019 and 2020 were analyzed...
2023: Frontiers in Nutrition
#32
JOURNAL ARTICLE
Julie Novakova Martinkova, Maria Teresa Ferretti, Alberto Ferrari, Ondrej Lerch, Veronika Matuskova, Juraj Secnik, Jakub Hort
INTRODUCTION: Choroid plexus (CP)-related mechanisms have been implicated in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease. In this pilot study, we aimed to elucidate the association between longitudinal changes in CP volume, sex and cognitive impairment. METHODS: We assessed longitudinal changes in CP volume in a cohort of n = 613 subjects across n = 2,334 datapoints from ADNI 2 and ADNI-GO, belonging to cognitively unimpaired (CN), stable mild cognitive impairment (MCI), clinically diagnosed Alzheimer's disease dementia (AD) or convertor (to either AD or MCI) subgroups...
2023: Frontiers in Psychiatry
#33
JOURNAL ARTICLE
R Terik Daly, Carolyn M Ernst, Olivier S Barnouin, Nancy L Chabot, Andrew S Rivkin, Andrew F Cheng, Elena Y Adams, Harrison F Agrusa, Elisabeth D Abel, Amy L Alford, Erik I Asphaug, Justin A Atchison, Andrew R Badger, Paul Baki, Ronald-L Ballouz, Dmitriy L Bekker, Julie Bellerose, Shyam Bhaskaran, Bonnie J Buratti, Saverio Cambioni, Michelle H Chen, Steven R Chesley, George Chiu, Gareth S Collins, Matthew W Cox, Mallory E DeCoster, Peter S Ericksen, Raymond C Espiritu, Alan S Faber, Tony L Farnham, Fabio Ferrari, Zachary J Fletcher, Robert W Gaskell, Dawn M Graninger, Musad A Haque, Patricia A Harrington-Duff, Sarah Hefter, Isabel Herreros, Masatoshi Hirabayashi, Philip M Huang, Syau-Yun W Hsieh, Seth A Jacobson, Stephen N Jenkins, Mark A Jensenius, Jeremy W John, Martin Jutzi, Tomas Kohout, Timothy O Krueger, Frank E Laipert, Norberto R Lopez, Robert Luther, Alice Lucchetti, Declan M Mages, Simone Marchi, Anna C Martin, Maria E McQuaide, Patrick Michel, Nicholas A Moskovitz, Ian W Murphy, Naomi Murdoch, Shantanu P Naidu, Hari Nair, Michael C Nolan, Jens Ormö, Maurizio Pajola, Eric E Palmer, James M Peachey, Petr Pravec, Sabina D Raducan, K T Ramesh, Joshua R Ramirez, Edward L Reynolds, Joshua E Richman, Colas Q Robin, Luis M Rodriguez, Lew M Roufberg, Brian P Rush, Carolyn A Sawyer, Daniel J Scheeres, Petr Scheirich, Stephen R Schwartz, Matthew P Shannon, Brett N Shapiro, Caitlin E Shearer, Evan J Smith, R Joshua Steele, Jordan K Steckloff, Angela M Stickle, Jessica M Sunshine, Emil A Superfin, Zahi B Tarzi, Cristina A Thomas, Justin R Thomas, Josep M Trigo-Rodríguez, B Teresa Tropf, Andrew T Vaughan, Dianna Velez, C Dany Waller, Daniel S Wilson, Kristin A Wortman, Yun Zhang
While no known asteroid poses a threat to Earth for at least the next century, the catalog of near-Earth asteroids is incomplete for objects whose impacts would produce regional devastation1,2 . Several approaches have been proposed to potentially prevent an asteroid impact with Earth by deflecting or disrupting an asteroid1-3 . A test of kinetic impact technology was identified as the highest priority space mission related to asteroid mitigation1 . NASA's Double Asteroid Redirection Test (DART) mission is the first full-scale test of kinetic impact technology...
March 1, 2023: Nature
#34
JOURNAL ARTICLE
Eugenio Martelli, Matilde Zamboni, Giovanni Sotgiu, Laura Saderi, Massimo Federici, Giuseppe M Sangiorgi, Mariangela V Puci, Allegra R Martelli, Teresa Messina, Paolo Frigatti, Maria Pia Borrelli, Carlo Ruotolo, Ilaria Ficarelli, Paolo Rubino, Francesco Pezzo, Luciano Carbonari, Andrea Angelini, Edoardo Galeazzi, Luca Calia Di Pinto, Franco M Fiore, Armando Palmieri, Giorgio Ventoruzzo, Giulia Mazzitelli, Franco Ragni, Antonio Bozzani, Enzo Forliti, Claudio Castagno, Pietro Volpe, Mafalda Massara, Diego Moniaci, Elisa Pagliasso, Tania Peretti, Mauro Ferrari, Nicola Troisi, Piero Modugno, Maurizio Maiorano, Umberto M Bracale, Marco Panagrosso, Mario Monaco, Giovanni Giordano, Giuseppe Natalicchio, Antonella Biello, Giovanni M Celoria, Alessio Amico, Mauro Di Bartolo, Massimiliano Martelli, Roberta Munaó, Davide Razzano, Giovanni Colacchio, Francesco Bussetti, Gaetano Lanza, Antonio Cardini, Bartolomeo Di Benedetto, Mario De Laurentis, Maurizio Taurino, Pasqualino Sirignano, Pierluigi Cappiello, Andrea Esposito, Santi Trimarchi, Silvia Romagnoli, Andrea Padricelli, Giorgio Giudice, Adolfo Crinisio, Giovanni Di Nardo, Giuseppe Battaglia, Rosario Tringale, Salvatore De Vivo, Rita Compagna, Valerio S Tolva, Ilenia D'Alessio, Ruggiero Curci, Simona Giovannetti, Giuseppe D'Arrigo, Giusi Basile, Dalmazio Frigerio, Gian Franco Veraldi, Luca Mezzetto, Arnaldo Ippoliti, Fabio M Oddi, Alberto M Settembrini
BACKGROUND: Identifying sex-related differences/variables associated with 30 day/1 year mortality in patients with chronic limb-threatening ischemia (CLTI). METHODS: Multicenter/retrospective/observational study. A database was sent to all the Italian vascular surgeries to collect all the patients operated on for CLTI in 2019. Acute lower-limb ischemia and neuropathic-diabetic foot are not included. FOLLOW-UP: One year. Data on demographics/comorbidities, treatments/outcomes, and 30 day/1 year mortality were investigated...
February 11, 2023: Journal of Personalized Medicine
#35
JOURNAL ARTICLE
Polianna Delfino Pereira, Magda Carvalho Pires, Virginia Mara Reis Gomes, Matheus Carvalho Alves Nogueira, Maria Clara Pontello Barbosa Lima, Alexandre Vargas Schwarzbold, Amanda de Oliveira Maurílio, Ana Luiza Bahia Alves Scotton, André Soares de Moura Costa, Barbara Lopes Farace, Bruno Mateus de Castro, Christiane Corrêa Rodrigues Cimini, Daniel Vitório Silveira, Daniela Ponce, Elayne Crestani Pereira, Eliane Würdig Roesch, Euler Roberto Fernandes Manenti, Evelin Paola de Almeida Cenci, Fernanda Costa Dos Santos, Fernando Anschau, Fernando Graça Aranha, Frederico Bartolazzi, Guilherme Fagundes Nascimento, Heloisa Reniers Vianna, Joanna D Arc Lyra Batista, Joice Coutinho de Alvarenga, Juliana da Silva Nogueira Carvalho, Juliana Machado-Rugolo, Karen Brasil Ruschel, Luanna Silva Monteiro Menezes, Luís César de Castro, Luiz Antônio Nasi, Maiara Anschau Floriani, Maíra Dias Souza, Maíra Viana Rego Souza-Silva, Marcelo Carneiro, Maria Aparecida Camargos Bicalho, Mariana Frizzo de Godoy, Milton Henriques Guimarães-Júnior, Patricia Klarmann Ziegelmann, Pedro Ledic Assaf, Petrônio José de Lima Martelli, Renan Goulart Finger, Saionara Cristina Francisco, Silvia Ferreira Araújo, Talita Fischer Oliveira, Thainara Conceição de Oliveira, Thalita Martins Lage, Vanessa Muller, Yuri Carlotto Ramires, Teresa Cristina de Abreu Ferrari, Milena Soriano Marcolino
OBJECTIVE: To analyze the clinical characteristics and outcomes of in-hospital patients with hospital- versus community-manifested COVID-19; and to evaluate the risk factors related to mortality in the first population. METHODS: This retrospective cohort included consecutive adult COVID-19 patients, hospitalized between March and September/2020. Demographic data, clinical characteristics and outcomes were extracted from medical records. Patients with hospital-manifested COVID-19 (study group) and those with community-manifested COVID-19 (control group) were matched by the propensity score model...
February 20, 2023: International Journal of Infectious Diseases: IJID
#36
Stefania Della Vecchia, Alessandra Tessa, Claudia Dosi, Jacopo Baldacci, Rosa Pasquariello, Antonella Antenora, Guja Astrea, Maria Teresa Bassi, Roberta Battini, Carlo Casali, Ettore Ciof, Greta Conti, Giovanna De Michele, Anna Rita Ferrari, Alessandro Filla, Chiara Fiorillo, Carlo Fusco, Salvatore Gallone, Chiara Germiniasi, Renzo Guerrini, Shalom Haggiag, Diego Lopergolo, Andrea Martinuzzi, Federico Melani, Andrea Mignarri, Elena Panzeri, Antonella Pini, Anna Maria Pinto, Francesca Pochiero, Guido Primiano, Elena Procopio, Alessandra Renieri, Romina Romaniello, Cristina Sancricca, Serenella Servidei, Carlotta Spagnoli, Chiara Ticci, Anna Rubegni, Filippo Maria Santorelli
No abstract text is available yet for this article.
February 16, 2023: Journal of Neurology
#37
JOURNAL ARTICLE
Giuseppina Brancaccio, Barbara Coco, Alessandra Nardi, Maria Giovanna Quaranta, Maria Elena Tosti, Luigina Ferrigno, Irene Cacciola, Vincenzo Messina, Luchino Chessa, Filomena Morisco, Michele Milella, Francesco Barbaro, Alessia Ciancio, Francesco Paolo Russo, Nicola Coppola, Pierluigi Blanc, Ernesto Claar, Gabriella Verucchi, Massimo Puoti, Anna Linda Zignego, Liliana Chemello, Salvatore Madonia, Stefano Fagiuoli, Alfredo Marzano, Carlo Ferrari, Pietro Lampertico, Vito Di Marco, Antonio Craxì, Teresa Antonia Santantonio, Giovanni Raimondo, Maurizia R Brunetto, Giovanni Battista Gaeta, Loreta A Kondili
OBJECTIVES: . The study measures trends in the profile of patients with chronic HBV linked to care in Italy. METHODS: . Cross sectional, multicentre, observational cohort (PITER cohort) of consecutive HBsAg-positive patients over the period 2019-2021 in 46 centres. The reference was the MASTER cohort collected over the years 2012-2015. Standard statistical methods were used. RESULTS: . The PITER cohort enrolled 4583 patients, of whom 21.8% were non-Italian natives...
February 13, 2023: International Journal of Infectious Diseases: IJID
#38
JOURNAL ARTICLE
Francesca Marini, Francesca Giusti, Elena Marasco, Luciano Xumerle, Katarzyna Malgorzata Kwiatkowska, Paolo Garagnani, Emmanuel Biver, Serge Ferrari, Giovanni Iolascon, Teresa Iantomasi, Maria Luisa Brandi
OBJECTIVE: Atypical femur fractures (AFFs) are rare fragility fractures originating at the lateral cortex of the femur, affecting the subtrochanteric or diaphyseal area of thebone with a transverse morphology. Occurrence of AFF is specifically associated with a small number of rare monogenic congenital metabolic bone disorders, such as hypophosphatasia, and with long-term treatment with antiresorptiondrugs. The exact pathogenesis of these fractures remains poorly understood and, except for cases of diagnosed HPP or other AFF-causing bone diseases, it is not possible to assess which patients are at higher riskof developing AFFs as a consequence of anti-resorption therapy...
January 10, 2023: European Journal of Endocrinology
#39
JOURNAL ARTICLE
Lilian Martins Oliveira Diniz, Jesiana Ferreira Pedrosa, Pedro Pires Pimenta, Luynne Lana Monteiro, Rafael Arantes Oliveira, André Vinícius Soares Barbosa, Joziele de Souza Lima, Bruna Campos Cardoso Vilela, Livya Isabella Teles de Oliveira Lima, Ana Laura Moreira Teixeira, Teresa Cristina de Abreu Ferrari
No abstract text is available yet for this article.
October 1, 2022: Pediatric Infectious Disease Journal
#40
JOURNAL ARTICLE
Marzia Rossi, Andrea Vecchi, Camilla Tiezzi, Valeria Barili, Paola Fisicaro, Amalia Penna, Ilaria Montali, Stephane Daffis, Simon P Fletcher, Anuj Gaggar, Jonathan Medley, Michael Graupe, Latesh Lad, Alessandro Loglio, Roberta Soffredini, Marta Borghi, Teresa Pollicino, Cristina Musolino, Arianna Alfieri, Federica Brillo, Diletta Laccabue, Marco Massari, Chiara Boarini, Gianluca Abbati, Giuseppe Pedrazzi, Gabriele Missale, Pietro Lampertico, Carlo Ferrari, Carolina Boni
OBJECTIVE: Exhausted hepatitis B virus (HBV)-specific CD8 T cells in chronic HBV infection are broadly heterogeneous. Characterisation of their functional impairment may allow to distinguish patients with different capacity to control infection and reconstitute antiviral function. DESIGN: HBV dextramer+CD8 T cells were analysed ex vivo for coexpression of checkpoint/differentiation markers, transcription factors and cytokines in 35 patients with HLA-A2+chronic hepatitis B (CHB) and in 29 control HBsAg negative CHB patients who seroconverted after NUC treatment or spontaneously...
January 30, 2023: Gut
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