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https://www.readbyqxmd.com/read/29350487/pediatric-patients-with-cutaneous-melanoma-a-european-study
#1
Ines B Brecht, Angela De Paoli, Gianni Bisogno, Daniel Orbach, Dominik T Schneider, Ulrike Leiter, Sonja Offenmueller, Giovanni Cecchetto, Jan Godzinski, Ewa Bien, Teresa Stachowicz-Stencel, Tal Ben-Ami, Stefano Chiaravalli, Andrea Maurichi, Gian Luca De Salvo, Silvia Sorbara, Christine Bodemer, Claus Garbe, Yves Reguerre, Andrea Ferrari
INTRODUCTION: Cutaneous melanoma is rare in childhood and published studies have mainly been retrospective single-institution series or small case series. Given the absence of clinical protocols dedicated to pediatric melanoma, the treatment approach is generally extrapolated from the ones applied to adults. METHODS: Coordinated by the European Cooperative Study Group for Pediatric Rare Tumors (EXPeRT), this study collected patients prospectively registered between 2002 and 2012 under national cooperative projects dedicated to rare pediatric tumors in Italy, Poland, Germany, and France...
January 19, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29340095/tumoral-immune-infiltrate-if-pd-l1-expression-and-role-of-cd8-tia-1-lymphocytes-in-localized-osteosarcoma-patients-treated-within-protocol-isg-os1
#2
Emanuela Palmerini, Claudio Agostinelli, Piero Picci, Stefano Pileri, Teresa Marafioti, Pier-Luigi Lollini, Katia Scotlandi, Alessandra Longhi, Maria Serena Benassi, Stefano Ferrari
Background: We hypothesized that immune-infiltrates were associated with superior survival, and examined a primary osteosarcoma tissue microarrays (TMAs) to test this hypothesis. Methods: 129 patients (pts) with localized osteosarcoma treated within protocol ISG-OS1 were included in the study. Clinical characteristics, expression of CD8, CD3, FOXP3, CD20, CD68/CD163 (tumor associated macrophage, TAM), Tia-1 (cytotoxic T cell), CD303 (plasmacytoid dendritic cells: pDC), Arginase-1 (myeloid derived suppressor cells: MDSC), PD-1 on immune-cells (IC), and PD-L1 on tumoral cells (TC) and IC were analysed and correlated with outcome...
December 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29298340/the-association-between-a-body-shape-index-and-cardiovascular-risk-in-overweight-and-obese-children-and-adolescents
#3
Chiara Mameli, Nir Y Krakauer, Jesse C Krakauer, Alessandra Bosetti, Chiara Matilde Ferrari, Norma Moiana, Laura Schneider, Barbara Borsani, Teresa Genoni, Gianvincenzo Zuccotti
A Body Shape Index (ABSI) and normalized hip circumference (Hip Index, HI) have been recently shown to be strong risk factors for mortality and for cardiovascular disease in adults. We conducted an observational cross-sectional study to evaluate the relationship between ABSI, HI and cardiometabolic risk factors and obesity-related comorbidities in overweight and obese children and adolescents aged 2-18 years. We performed multivariate linear and logistic regression analyses with BMI, ABSI, and HI age and sex normalized z scores as predictors to examine the association with cardiometabolic risk markers (systolic and diastolic blood pressure, fasting glucose and insulin, total cholesterol and its components, transaminases, fat mass % detected by bioelectrical impedance analysis) and obesity-related conditions (including hepatic steatosis and metabolic syndrome)...
2018: PloS One
https://www.readbyqxmd.com/read/29279175/mr-elastography-is-effective-for-the-non-invasive-evaluation-of-fibrosis-and-necroinflammatory-activity-in-patients-with-nonalcoholic-fatty-liver-disease
#4
Luciana Costa-Silva, Silvia Marinho Ferolla, Agnaldo Soares Lima, Paula Vieira Teixeira Vidigal, Teresa Cristina de Abreu Ferrari
OBJECTIVES: To evaluate the performance of magnetic resonance elastography (MRE) in diagnosing and staging hepatic fibrosis in patients with histologically confirmed nonalcoholic fatty liver disease (NAFLD) and in distinguishing simple steatosis from nonalcoholic steatohepatitis (NASH). METHODS: Ninety subjects (49 NAFLD patients and 41 healthy volunteers) were prospectively enrolled. Liver stiffness measured by MRE was correlated with the grade of fibrosis and/or inflammation determined by liver biopsy...
January 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29219632/budd-chiari-syndrome-associated-with-al-amyloidosis-a-coagulation-paradox
#5
Guilherme Grossi Lopes Cançado, Luciana Costa Faria, Fernanda Maria Farage Osório, Paula Vieira Teixeira Vidigal, Cláudia Alves Couto, Teresa Cristina de Abreu Ferrari
No abstract text is available yet for this article.
December 8, 2017: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/28969901/rule-reactivation-and-capture-errors-in-goal-directed-behaviour
#6
María Roca, Milagros García, María Juliana Torres Ardila, María Luz González Gadea, Teresa Torralva, Jesica Ferrari, Agustín Ibáñez, Facundo Manes, John Duncan
In everyday life people may act automatically, following "unwanted" lines of action which are triggered by contextual cues and may interfere with current goals. Such occurrences are known as "capture errors" in reference to errors that occur when a more salient behaviour takes place when a similar, but less salient, action was intended. Clinical neuropsychological studies suggest that reactivation of previous rules may play an important role in behavioural interference, but such reactivation has been little studied in normal subjects and simple experimental tasks...
September 10, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28964784/synergistic-efficacy-of-irinotecan-and-sunitinib-combination-in-preclinical-models-of-anaplastic-thyroid-cancer
#7
Teresa Di Desidero, Alessandro Antonelli, Paola Orlandi, Silvia Martina Ferrari, Anna Fioravanti, Greta Alì, Gabriella Fontanini, Fulvio Basolo, Giulio Francia, Guido Bocci
The identification of new therapeutic strategies is urgently needed for the management of patients affected by anaplastic thyroid cancer (ATC) due to their short survival and poor prognosis. Aim of the study was to determine the activity of the combination irinotecan/sunitinib on ATC cell growth in vitro and the antitumor effects in vivo. Proliferation assays were performed for 72 h on ATC cell lines exposed to the combination of SN-38, the active metabolite of irinotecan, and sunitinib. The simultaneous combination of sunitinib and SN-38, quantified by the combination index, determined a high synergism on ATC cells, increasing the intracellular concentrations of SN-38...
September 28, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28941702/young-bamboo-culm-potential-food-as-source-of-fiber-and-starch
#8
Mária Herminia Ferrari Felisberto, Patricia Satie Endo Miyake, Antonio Ludovico Beraldo, Maria Teresa Pedrosa Silva Clerici
With the objective of widening the use of bamboo in the food industry, the present work aimed to produce and characterize the young bamboo culm flours from varieties Dendrocalamus asper, Bambusa tuldoides and Bambusa vulgaris as potential sources of fiber and starch. The young culms were collected, cut in three sections (bottom, middle, top), processed into flour, and they were physically, chemically and technologically analyzed. The data were obtained in triplicate and evaluated by means of average differences, using analysis of variance (ANOVA) and Scott-Knott test (p<0...
November 2017: Food Research International
https://www.readbyqxmd.com/read/28900662/erratum-to-tubulin-related-cerebellar-dysplasia-definition-of-a-distinct-pattern-of-cerebellar-malformation
#9
Romina Romaniello, Filippo Arrigoni, Elena Panzeri, Andrea Poretti, Alessia Micalizzi, Andrea Citterio, Maria Francesca Bedeschi, Angela Berardinelli, Raffaella Cusmai, Stefano D'Arrigo, Alessandro Ferraris, Annette Hackenberg, Alma Kuechler, Margherita Mancardi, Sara Nuovo, Barbara Oehl-Jaschkowitz, Andrea Rossi, Sabrina Signorini, Frank Tüttelmann, Dagmar Wahl, Ute Hehr, Eugen Boltshauser, Maria Teresa Bassi, Enza Maria Valente, Renato Borgatti
No abstract text is available yet for this article.
December 2017: European Radiology
https://www.readbyqxmd.com/read/28851564/x-linked-parkinsonism-with-intellectual-disability-caused-by-novel-mutations-and-somatic-mosaicism-in-rab39b-gene
#10
Andrea Ciammola, Paola Carrera, Alessio Di Fonzo, Jenny Sassone, Roberta Villa, Barbara Poletti, Maurizio Ferrari, Floriano Girotti, Edoardo Monfrini, Gabriele Buongarzone, Vincenzo Silani, Claudia Maria Cinnante, Maria Lidia Mignogna, Patrizia D'Adamo, Maria Teresa Bonati
BACKGROUND: RAB39B pathogenic variants cause X-linked Parkinsonism associated with Intellectual Disability, known as Waisman syndrome, a very rare disorder that has been mainly identified through exome sequencing in large Parkinson's disease cohorts. In this study we searched for pathogenic variants in RAB39B in two Italian families affected by X-linked early-onset Parkinsonism and Intellectual Disability. METHODS: Three patients received neurological evaluation and underwent RAB39B sequencing...
August 26, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28741307/modeling-cost-effectiveness-and-health-gains-of-a-universal-versus-prioritized-hepatitis-c-virus-treatment-policy-in-a-real-life-cohort
#11
Loreta A Kondili, Federica Romano, Francesca Romana Rolli, Matteo Ruggeri, Stefano Rosato, Maurizia Rossana Brunetto, Anna Linda Zignego, Alessia Ciancio, Alfredo Di Leo, Giovanni Raimondo, Carlo Ferrari, Gloria Taliani, Guglielmo Borgia, Teresa Antonia Santantonio, Pierluigi Blanc, Giovanni Battista Gaeta, Antonio Gasbarrini, Luchino Chessa, Elke Maria Erne, Erica Villa, Donatella Ieluzzi, Francesco Paolo Russo, Pietro Andreone, Maria Vinci, Carmine Coppola, Liliana Chemello, Salvatore Madonia, Gabriella Verucchi, Marcello Persico, Massimo Zuin, Massimo Puoti, Alfredo Alberti, Gerardo Nardone, Marco Massari, Giuseppe Montalto, Giuseppe Foti, Maria Grazia Rumi, Maria Giovanna Quaranta, Americo Cicchetti, Antonio Craxì, Stefano Vella
We evaluated the cost-effectiveness of two alternative direct-acting antiviral (DAA) treatment policies in a real-life cohort of hepatitis C virus-infected patients: policy 1, "universal," treat all patients, regardless of fibrosis stage; policy 2, treat only "prioritized" patients, delay treatment of the remaining patients until reaching stage F3. A liver disease progression Markov model, which used a lifetime horizon and health care system perspective, was applied to the PITER cohort (representative of Italian hepatitis C virus-infected patients in care)...
December 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28677066/tubulin-related-cerebellar-dysplasia-definition-of-a-distinct-pattern-of-cerebellar-malformation
#12
Romina Romaniello, Filippo Arrigoni, Elena Panzeri, Andrea Poretti, Alessia Micalizzi, Andrea Citterio, Maria Francesca Bedeschi, Angela Berardinelli, Raffaella Cusmai, Stefano D'Arrigo, Alessandro Ferraris, Annette Hackenberg, Alma Kuechler, Margherita Mancardi, Sara Nuovo, Barbara Oehl-Jaschkowitz, Andrea Rossi, Sabrina Signorini, Frank Tüttelmann, Dagmar Wahl, Ute Hehr, Eugen Boltshauser, Maria Teresa Bassi, Enza Maria Valente, Renato Borgatti
OBJECTIVE: To determine the neuroimaging pattern of cerebellar dysplasia (CD) and other posterior fossa morphological anomalies associated with mutations in tubulin genes and to perform clinical and genetic correlations. METHODS: Twenty-eight patients harbouring 23 heterozygous pathogenic variants (ten novel) in tubulin genes TUBA1A (n = 10), TUBB2B (n = 8) or TUBB3 (n = 5) were studied by a brain MRI scan performed either on a 1.5 T (n = 10) or 3 T (n = 18) MR scanner with focus on the posterior fossa...
December 2017: European Radiology
https://www.readbyqxmd.com/read/28665473/winners-cup-a-national-football-tournament-brings-together-adolescent-patients-with-cancer-from-all-over-italy
#13
Matteo Silva, Marco Chisari, Stefano Signoroni, Alberto Bassani, Luca Tagliabue, Angelo Ricci, Mirco Daversa, Massimo Achini, Filippo Spreafico, Michele Murelli, Giuseppe Maria Milano, Gianni Bisogno, Luca Coccoli, Massimo Conte, Alberto Garaventa, Paolo Indolfi, Silverio Perrotta, Marco Spinelli, Federico Mercolini, Pietro Soloni, Marta Pierobon, Andrea Di Cataldo, Teresa Perillo, Maurizio Mascarin, Elisa Coassin, Laura Veneroni, Michela Casanova, Maura Massimino, Andrea Ferrari
Società Scientifiche Italiane Insieme per gli Adolescenti con Malattie Onco-ematologiche (SIAMO) is an Italian nationwide scheme that focuses on adolescent patients with cancer. Some of its activities include promoting dedicated local projects at the various oncology centers all over the country and organizing events to improve awareness regarding cancer in adolescence. It is with these aims in mind that it organized the Winners' Cup, a football tournament between Italian adolescents who had (or had had) pediatric cancers...
July 31, 2017: Tumori
https://www.readbyqxmd.com/read/28608367/the-rome-transplant-network-model-compared-to-the-italian-bone-marrow-donor-registry-activity-for-unrelated-donor-search-process-and-transplant-efficiency-for-hematologic-malignancy
#14
COMPARATIVE STUDY
Alessandra Picardi, William Arcese, Simona Pollichieni, Fabio Di Piazza, Ilaria Mangione, Anna Maria Gallina, Raffaella Cerretti, Laura Cudillo, Gottardo De Angelis, Andrea Mengarelli, Teresa Dentamaro, Maria Cristina Tirindelli, Anna Chierichini, Antonella Ferrari, Renato Marciano, Marco Andreani, Francesca Bonifazi, Nicoletta Sacchi
BACKGROUND: From 2011 to 2014, a total of 71% of the 3834 patients with hematologic malignancies successfully identified a matched unrelated donor (MUD) through the Italian Bone Marrow Donor Registry (IBMDR), corresponding to a transplant efficiency of 62%. STUDY DESIGN AND METHODS: From 2006, the Rome Transplant Network (RTN) followed a hierarchical selection strategy for the alternative donor search: first MUD, second cord blood, and third haploidentical donor...
July 2017: Transfusion
https://www.readbyqxmd.com/read/28394330/thymosin-%C3%AE-1-represents-a-potential-potent-single-molecule-based-therapy-for-cystic-fibrosis
#15
Luigina Romani, Vasilis Oikonomou, Silvia Moretti, Rossana G Iannitti, Maria Cristina D'Adamo, Valeria R Villella, Marilena Pariano, Luigi Sforna, Monica Borghi, Marina M Bellet, Francesca Fallarino, Maria Teresa Pallotta, Giuseppe Servillo, Eleonora Ferrari, Paolo Puccetti, Guido Kroemer, Mauro Pessia, Luigi Maiuri, Allan L Goldstein, Enrico Garaci
Cystic fibrosis (CF) is caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) that compromise its chloride channel activity. The most common mutation, p.Phe508del, results in the production of a misfolded CFTR protein, which has residual channel activity but is prematurely degraded. Because of the inherent complexity of the pathogenetic mechanisms involved in CF, which include impaired chloride permeability and persistent lung inflammation, a multidrug approach is required for efficacious CF therapy...
May 2017: Nature Medicine
https://www.readbyqxmd.com/read/28391016/fasting-biases-%C3%AE-opioid-receptors-toward-%C3%AE-arrestin2-dependent-signaling-in-the-accumbens-shell
#16
Simona Scheggi, Alberto Ferrari, Teresa Pelliccia, Paola Devoto, Maria Graziella De Montis, Carla Gambarana
The μ-opioid receptor (MOR) and dopamine D1 receptor are co-expressed in the medium spiny neurons of striatal areas and the signaling pathways activated by these two receptors are in functional competition. However, in certain conditions an integrated response mediated by the dopamine D1 receptor transduction system is observed. In mice, morphine administration induces hypermotility and this response has been described in terms of a β-arrestin2-dependent mechanism that favors prevalent dopamine D1 receptor activation...
June 3, 2017: Neuroscience
https://www.readbyqxmd.com/read/28341462/asthma-management-in-a-specialist-setting-results-of-an-italian-respiratory-society-survey
#17
Fulvio Braido, Ilaria Baiardini, Pietro Alleri, Elena Bacci, Carlo Barbetta, Michela Bellocchia, Alida Benfante, Francesco Blasi, Caterina Bucca, Maria Teresa Busceti, Stefano Centanni, Maria Cristina Colanardi, Marco Contoli, Angelo Corsico, Maria D'Amato, Fabiano Di Marco, Dottorini Marco, Marta Ferrari, Giovanni Florio, Alessandro Giuseppe Fois, Maria Pia Foschino Barbaro, Garuti Silvia, Giuseppe Girbino, Amelia Grosso, Manuela Latorre, Sara Maniscalco, Francesco Mazza, Carlo Mereu, Giorgia Molinengo, Josuel Ora, Pierluigi Paggiaro, Vincenzo Patella, Girolamo Pelaia, Pietro Pirina, Alfio Proietto, Paola Rogliani, Pierachille Santus, Nicola Scichilone, Francesca Simioli, Paolo Solidoro, Silvia Terraneo, Umberto Zuccon, Giorgio Walter Canonica
BACKGROUND: Asthma considerably impairs patients' quality of life and increases healthcare costs. Severity, morbidity, and degree of disease control are the major drivers of its clinical and economic impact. National scientific societies are required to monitor the application of international guidelines and to adopt strategies to improve disease control and better allocate resources. AIM: to provide a detailed picture of the characteristics of asthma patients and modalities of asthma management by specialists in Italy and to develop recommendations for the daily management of asthma in a specialist setting...
June 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28285268/cardiac-manifestations-of-parasitic-diseases
#18
REVIEW
Maria Carmo P Nunes, Milton Henriques Guimarães Júnior, Adriana Costa Diamantino, Claudio Leo Gelape, Teresa Cristina Abreu Ferrari
The heart may be affected directly or indirectly by a variety of protozoa and helminths. This involvement may manifest in different ways, but the syndromes resulting from impairment of the myocardium and pericardium are the most frequent. The myocardium may be invaded by parasites that trigger local inflammatory response with subsequent myocarditis or cardiomyopathy, as occurs in Chagas disease, African trypanosomiasis, toxoplasmosis, trichinellosis and infection with free-living amoebae. In amoebiasis and echinococcosis, the pericardium is the structure most frequently involved with consequent pericardial effusion, acute pericarditis, cardiac tamponade or constrictive pericarditis...
May 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28231331/mesenchymal-stromal-cells-mscs-induce-ex-vivo-proliferation-and-erythroid-commitment-of-cord-blood-haematopoietic-stem-cells-cb-cd34-cells
#19
Simone Perucca, Andrea Di Palma, Pier Paolo Piccaluga, Claudia Gemelli, Elisa Zoratti, Giulio Bassi, Edoardo Giacopuzzi, Andrea Lojacono, Giuseppe Borsani, Enrico Tagliafico, Maria Teresa Scupoli, Simona Bernardi, Camilla Zanaglio, Federica Cattina, Valeria Cancelli, Michele Malagola, Mauro Krampera, Mirella Marini, Camillo Almici, Sergio Ferrari, Domenico Russo
A human bone marrow-derived mesenchymal stromal cell (MSCs) and cord blood-derived CD34+ stem cell co-culture system was set up in order to evaluate the proliferative and differentiative effects induced by MSCs on CD34+ stem cells, and the reciprocal influences on gene expression profiles. After 10 days of co-culture, non-adherent (SN-fraction) and adherent (AD-fraction) CD34+ stem cells were collected and analysed separately. In the presence of MSCs, a significant increase in CD34+ cell number was observed (fold increase = 14...
2017: PloS One
https://www.readbyqxmd.com/read/28219620/brain-structural-correlates-of-executive-and-social-cognition-profiles-in-behavioral-variant-frontotemporal-dementia-and-elderly-bipolar-disorder
#20
Sandra Baez, Clara Pinasco, María Roca, Jesica Ferrari, Blas Couto, Indira García-Cordero, Agustín Ibañez, Francy Cruz, Pablo Reyes, Diana Matallana, Facundo Manes, Marcelo Cetcovich, Teresa Torralva
An early stage of behavioral variant frontotemporal dementia (bvFTD) often displays a mix of behavioral disturbances and personality changes hindering a differential diagnosis from elderly bipolar disorder (BD), making this process a big challenge. However, no studies have compared these pathologies from neuropsychological and neuroanatomical perspectives. The aim of the present study was to compare the executive functions (EF) and social cognition profiles as well as the structural neuroimaging of bvFTD and elderly patients with BD...
February 17, 2017: Neuropsychologia
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