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Ferrari, teresa

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https://www.readbyqxmd.com/read/28190616/plasma-levels-of-vasostatin-1-a-chromogranin-a-fragment-are-associated-with-carotid-artery-maximum-stenosis-a-pilot-study
#1
Tiziana Bachetti, Alberto Ferrari Bardile, Teresa Lucia Aloi, Barbara Colombo, Emma Assi, Giuseppina Savino, Andrea Vercelli, Roberto Colombo, Angelo Corti
BACKGROUND: Chromogranin A (CgA), a circulating protein released by the neuroendocrine system, can regulate vascular physiology and angiogenesis. Full-length CgA (CgA1-439) and its fragment CgA1-76 (called vasostatin-1, VS-1) preserve the physiological integrity of the endothelial barrier function and are antiangiogenic, whereas CgA1-373 is proangiogenic. We investigated whether these polypeptides are altered in patients with various degrees of carotid artery atherosclerosis. METHODS: We studied 81 patients with carotid artery atherosclerosis, asymptomatic for cerebrovascular diseases...
February 6, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28151888/pediatric-hodgkin-lymphoma-predictive-value-of-interim-18f-fdg-pet-ct-in-therapy-response-assessment
#2
Cristina Ferrari, Artor Niccoli Asabella, Nunzio Merenda, Corinna Altini, Margherita Fanelli, Paola Muggeo, Francesco De Leonardis, Teresa Perillo, Nicola Santoro, Giuseppe Rubini
We investigated the prognostic value of interim F-FDG PET/CT (PET-2) in pediatric Hodgkin lymphoma (pHL), evaluating both visual and semiquantitative analysis.Thirty pHL patients (age ≤16) underwent serial F-FDG PET/CT: at baseline (PET-0), after 2 cycles of chemotherapy (PET-2) and at the end of first-line chemotherapy (PET-T). PET response assessment was carried out visually according to the Deauville Score (DS), as well as semiquantitatively by using the semiquantitative parameters reduction from PET-0 to PET-2 (ΔΣSUVmax0-2, ΔΣSUVmean0-2)...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28080965/feeling-learning-from-and-being-aware-of-inner-states-interoceptive-dimensions-in-neurodegeneration-and-stroke
#3
Indira García-Cordero, Lucas Sedeño, Laura de la Fuente, Andrea Slachevsky, Gonzalo Forno, Francisco Klein, Patricia Lillo, Jesica Ferrari, Clara Rodriguez, Julian Bustin, Teresa Torralva, Sandra Baez, Adrian Yoris, Sol Esteves, Margherita Melloni, Paula Salamone, David Huepe, Facundo Manes, Adolfo M García, Agustín Ibañez
Interoception is a complex process encompassing multiple dimensions, such as accuracy, learning and awareness. Here, we examined whether each of those dimensions relies on specialized neural regions distributed throughout the vast interoceptive network. To this end, we obtained relevant measures of cardiac interoception in healthy subjects and patients offering contrastive lesion models of neurodegeneration and focal brain damage: behavioural variant fronto-temporal dementia (bvFTD), Alzheimer's disease (AD) and fronto-insular stroke...
November 19, 2016: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28040484/development-of-an-experimental-model-of-schistosomal-myeloradiculopathy
#4
Tiago Pinheiro Vaz de Carvalho, Teresa Cristina Abreu Ferrari, Josimari Melo de Santana, Victor Antônio Santos Viana, José Aislan Correia Santos, Wheverton Correia do Nascimento, Kamilla Mayara Lucas da Cruz, Karina Conceição Gomes Machado de Araújo
Schistosomal myeloradiculopathy (SMR) is a severe form of presentation of schistosomiasis in which Schistosoma spp. affect the spinal cord. The aims of the present study were to develop an animal model of SMR caused by S. mansoni, to characterize both sensory and motor abnormalities in the infected animals, and to investigate the relationship of the sensory, motor and histological findings with the progression of the infection over time. Mechanical sensitivity and behavioral tests were performed followed by euthanasia in male Wistar rats divided into six groups of five animals each, on days 5, 10, 20 and 30 after infection of S...
March 2017: Acta Tropica
https://www.readbyqxmd.com/read/28027830/erratum-to-systematic-versus-on-demand-early-palliative-care-a-randomised-clinical-trial-assessing-quality-of-care-and-treatment-aggressiveness-near-the-end-of-life-eur-j-cancer-69-2016-110-118
#5
Marco Maltoni, Emanuela Scarpi, Monia Dall'Agata, Stefania Schiavon, Claudia Biasini, Carla Codecà, Chiara Maria Broglia, Elisabetta Sansoni, Roberto Bortolussi, Ferdinando Garetto, Luisa Fioretto, Maria Teresa Cattaneo, Alice Giacobino, Massimo Luzzani, Giovanna Luchena, Sara Alquati, Silvia Quadrini, Vittorina Zagonel, Luigi Cavanna, Daris Ferrari, Paolo Pedrazzoli, Giovanni Luca Frassineti, Antonella Galiano, Andrea Casadei Gardini, Manlio Monti, Oriana Nanni
No abstract text is available yet for this article.
December 24, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27939857/blockade-of-the-il-1r1-tlr4-pathway-mediates-disease-modification-therapeutic-effects-in-a-model-of-acquired-epilepsy
#6
Valentina Iori, Anand M Iyer, Teresa Ravizza, Luca Beltrame, Lara Paracchini, Sergio Marchini, Milica Cerovic, Cameron Hill, Mariella Ferrari, Massimo Zucchetti, Monica Molteni, Carlo Rossetti, Riccardo Brambilla, H Steve White, Maurizio D'Incalci, Eleonora Aronica, Annamaria Vezzani
We recently discovered that forebrain activation of the IL-1 receptor/Toll-like receptor (IL-1R1/TLR4) innate immunity signal plays a pivotal role in neuronal hyperexcitability underlying seizures in rodents. Since this pathway is activated in neurons and glia in human epileptogenic foci, it represents a potential target for developing drugs interfering with the mechanisms of epileptogenesis that lead to spontaneous seizures. The lack of such drugs represents a major unmet clinical need. We tested therefore novel therapies inhibiting the IL-1R1/TLR4 signaling in an established murine model of acquired epilepsy...
December 9, 2016: Neurobiology of Disease
https://www.readbyqxmd.com/read/27852256/health-conditions-of-inmates-in-italy
#7
Fabio Voller, Caterina Silvestri, Gianrocco Martino, Eleonora Fanti, Giorgio Bazzerla, Fabio Ferrari, Marco Grignani, Sandro Libianchi, Antonio Maria Pagano, Franco Scarpa, Cristina Stasi, Teresa Di Fiandra
BACKGROUND: Several studies have shown that prison is characterized by a higher prevalence of chronic diseases than unconfined settings. The aim of this study was to describe the characteristics and health of inmates, focusing on internal diseases. METHODS: We designed a specific clinical record using the Python programming language. We considered all of the diagnoses according to the ICD-9-CM. RESULTS: Of a total of 17,086 inmates, 15,751 were enrolled in our study (M = 14,835; F = 869), corresponding to 92...
November 16, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27821313/systematic-versus-on-demand-early-palliative-care-a-randomised-clinical-trial-assessing-quality-of-care-and-treatment-aggressiveness-near-the-end-of-life
#8
Marco Maltoni, Emanuela Scarpi, Monia Dall'Agata, Stefania Schiavon, Claudia Biasini, Carla Codecà, Chiara Maria Broglia, Elisabetta Sansoni, Roberto Bortolussi, Ferdinando Garetto, Luisa Fioretto, Maria Teresa Cattaneo, Alice Giacobino, Massimo Luzzani, Giovanna Luchena, Sara Alquati, Silvia Quadrini, Vittorina Zagonel, Luigi Cavanna, Daris Ferrari, Paolo Pedrazzoli, Giovanni Luca Frassineti, Antonella Galiano, Andrea Casadei Gardini, Manlio Monti, Oriana Nanni
AIM: Early palliative care (EPC) in oncology has shown sparse evidence of a positive impact on patient outcomes, quality of care outcomes and costs. PATIENTS AND METHODS: Data for this secondary analysis were taken from a trial of 207 outpatients with metastatic pancreatic cancer randomly assigned to receive standard cancer care plus on-demand EPC (standard arm) or standard cancer care plus systematic EPC (interventional arm). After 20 months' follow-up, 149 (80%) had died...
December 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27788995/persistent-fever-after-pacemaker-lead-extraction
#9
Maria Carmo Pereira Nunes, Túlio Pinho Navarro, Mariana de Braga Lima Carvalho, Nicole de Paula Aarão Faleiro Maia, Ricardo Jayme Procópio, Teresa Cristina Abreu Ferrari
The implant indication of cardiac electronic devices continues to expand; therefore, we have observed increasing complications related to their removal. We describe the case of a patient who presented with prolonged bloodstream infection after having undergone removal of a pacemaker. After extensive workup for fever of unknown origin and antibiotic therapy without any improvement, it was possible to demonstrate a foreign body in the right subclavian vein and superior vena cava corresponding to the distal part of the right ventricular lead...
May 2016: Indian Pacing and Electrophysiology Journal
https://www.readbyqxmd.com/read/27742577/comparison-of-the-tolerability-profile-of-controlled-release-oral-morphine-and-oxycodone-for-cancer-pain-treatment-an-open-label-randomized-controlled-trial
#10
Ernesto Zecca, Cinzia Brunelli, Paola Bracchi, Giuseppe Biancofiore, Carlo De Sangro, Roberto Bortolussi, Luigi Montanari, Marco Maltoni, Cecilia Moro, Ugo Colonna, Gabriele Finco, Maria Teresa Roy, Vittorio Ferrari, Oscar Alabiso, Giovanni Rosti, Stein Kaasa, Augusto Caraceni
CONTEXT: Oxycodone and morphine are recommended as first-choice opioids for moderate/severe cancer pain, but evidence about their relative tolerability has significant methodological limitations. OBJECTIVES: This study was mainly aimed at comparing the risk of developing adverse events (AEs) with controlled-release oral morphine vs. oxycodone; secondary aims were comparing their analgesic efficacy and testing heterogeneity in tolerability across different age and renal function subgroups...
December 2016: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/27727263/-burden-in-caregivers-of-psychiatric-patients-attending-psychodynamic-multifamily-groups-preliminary-results-of-an-empirical-study
#11
Maria Teresa Gargano, Grazia Serantoni, Fiorella Ceppi, Marco D'Alema, Luisella Ferraris, Paola Innocente, Fiorella Lanzi, Andrea Narracci, Federico Russo, Marcella Venier
AIM: The main aim of this study is to investigate the burden in relatives of psychiatric patients attending long-term psychodynamic multifamily groups (18 months) of some Mental Health Departments of Lazio Region. A further aim is to verify if the decrease of the burden and the group participation are associated with a reduction of psychiatric symptoms in patients. METHODS: The sample consisted of 13 patients (10 men and 3 women) with severe personality disorder with at least one psychotic episode and 42 caregivers (15 men and 27 women)...
July 2016: Rivista di Psichiatria
https://www.readbyqxmd.com/read/27499327/deciphering-variability-of-pkd1-and-pkd2-in-an-italian-cohort-of-643-patients-with-autosomal-dominant-polycystic-kidney-disease-adpkd
#12
Paola Carrera, Silvia Calzavara, Riccardo Magistroni, Johan T den Dunnen, Francesca Rigo, Stefania Stenirri, Francesca Testa, Piergiorgio Messa, Roberta Cerutti, Francesco Scolari, Claudia Izzi, Alberto Edefonti, Susanna Negrisolo, Elisa Benetti, Maria Teresa Sciarrone Alibrandi, Paolo Manunta, Alessandra Boletta, Maurizio Ferrari
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most common hereditary kidney disease. We analysed PKD1 and PKD2, in a large cohort of 440 unrelated Italian patients with ADPKD and 203 relatives by direct sequencing and MLPA. Molecular and detailed phenotypic data have been collected and submitted to the PKD1/PKD2 LOVD database. This is the first large retrospective study in Italian patients, describing 701 variants, 249 (35.5%) already associated with ADPKD and 452 (64.5%) novel. According to the criteria adopted, the overall detection rate was 80% (352/440)...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27406979/cardiac-resynchronization-therapy-guided-by-multimodality-cardiac-imaging
#13
Matteo Bertini, Donato Mele, Michele Malagù, Andrea Fiorencis, Tiziano Toselli, Francesca Casadei, Teresa Cannizzaro, Cristina Fragale, Alessandro Fucili, Elena Campagnolo, Giorgio Benea, Roberto Ferrari
AIMS: Up to 30-45% of implanted patients are non-responders to CRT. We evaluated the role of a 'CRT team' using cardiac magnetic resonance (CMR) and longitudinal myocardial strain to identify the target area defined as the most delayed and viable region for LV pacing. METHODS AND RESULTS: A total of 100 heart failure patients candidates for CRT divided into two groups were enrolled. Group 1 consisted of 50 consecutive patients scheduled for CRT and prospectively included...
November 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27367724/beneficial-effect-of-synbiotic-supplementation-on-hepatic-steatosis-and-anthropometric-parameters-but-not-on-gut-permeability-in-a-population-with-nonalcoholic-steatohepatitis
#14
Silvia M Ferolla, Cláudia A Couto, Luciana Costa-Silva, Geyza N A Armiliato, Cristiano A S Pereira, Flaviano S Martins, Maria de Lourdes A Ferrari, Eduardo G Vilela, Henrique O G Torres, Aloísio S Cunha, Teresa C A Ferrari
Nonalcoholic fatty liver disease is the most prevalent chronic liver disease in Western countries; it can progress to nonalcoholic steatohepatitis (NASH), cirrhosis and hepatocarcinoma. The importance of gut-liver-adipose tissue axis has become evident and treatments targeting gut microbiota may improve inflammatory and metabolic parameters in NASH patients. In a randomized, controlled clinical trial, involving 50 biopsy-proven NASH patients, we investigated the effects of synbiotic supplementation on metabolic parameters, hepatic steatosis, intestinal permeability, small intestinal bacterial overgrowth (SIBO) and lipopolysaccharide (LPS) serum levels...
June 28, 2016: Nutrients
https://www.readbyqxmd.com/read/27308921/chemoselective-dimerization-of-phosphates
#15
Alexandre Hofer, Elia Marques, Nicole Kieliger, Sarah-Kirsten N Gatter, Sara Jordi, Elena Ferrari, Manuel Hofmann, Teresa B Fitzpatrick, Michael O Hottiger, Henning J Jessen
A methodology for the synthesis of oligophosphate conjugates using phosphordiamidites is described. This strategy facilitates the straightforward preparation of C2-symmetric dinucleoside tri-, penta-, and heptaphosphates. Moreover, unsymmetric compounds such as thiamine adenosine triphosphate and thiamine cytidine triphosphate can be prepared. The material is used to study the inhibitory activity of thiaminylated nucleotides against adenosine diphosphate ribosyltransferases.
July 1, 2016: Organic Letters
https://www.readbyqxmd.com/read/27296932/modifiable-causes-of-premature-death-in-middle-age-in-western-europe-results-from-the-epic-cohort-study
#16
David C Muller, Neil Murphy, Mattias Johansson, Pietro Ferrari, Konstantinos K Tsilidis, Marie-Christine Boutron-Ruault, Francoise Clavel, Laureen Dartois, Kuanrong Li, Rudolf Kaaks, Cornelia Weikert, Manuela Bergmann, Heiner Boeing, Anne Tjønneland, Kim Overvad, M Luisa Redondo, Antonio Agudo, Elena Molina-Portillo, Jone M Altzibar, Lluís Cirera, Eva Ardanaz, Kay-Tee Khaw, Nicholas J Wareham, Timothy J Key, Ruth C Travis, Christina Bamia, Philippos Orfanos, Antonia Trichopoulou, Domenico Palli, Valeria Pala, Rosario Tumino, Paolo Vineis, Salvatore Panico, H Bas Bueno-de-Mesquita, W M Monique Verschuren, Ellen A Struijk, Petra H Peeters, Gunnar Engström, Olle Melander, Malin Sund, Elisabete Weiderpass, Guri Skeie, Eiliv Lund, Teresa Norat, Marc Gunter, Elio Riboli, Paul Brennan
BACKGROUND: Life expectancy is increasing in Europe, yet a substantial proportion of adults still die prematurely before the age of 70 years. We sought to estimate the joint and relative contributions of tobacco smoking, hypertension, obesity, physical inactivity, alcohol and poor diet towards risk of premature death. METHODS: We analysed data from 264,906 European adults from the EPIC prospective cohort study, aged between 40 and 70 years at the time of recruitment...
June 14, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27245348/clinical-pregenetic-screening-for-stroke-monogenic-diseases-results-from-lombardia-gens-registry
#17
Anna Bersano, Hugh Stephen Markus, Silvana Quaglini, Eloisa Arbustini, Silvia Lanfranconi, Giuseppe Micieli, Giorgio B Boncoraglio, Franco Taroni, Cinzia Gellera, Silvia Baratta, Silvana Penco, Lorena Mosca, Maurizia Grasso, Paola Carrera, Maurizio Ferrari, Cristina Cereda, Gaetano Grieco, Stefania Corti, Dario Ronchi, Maria Teresa Bassi, Laura Obici, Eugenio A Parati, Alessando Pezzini, Maria Luisa De Lodovici, Elena P Verrengia, Giorgio Bono, Francesca Mazucchelli, Davide Zarcone, Maria Vittoria Calloni, Patrizia Perrone, Bianca Maria Bordo, Antonio Colombo, Alessandro Padovani, Anna Cavallini, Simone Beretta, Carlo Ferrarese, Cristina Motto, Elio Agostoni, Graziella Molini, Francesco Sasanelli, Manuel Corato, Simona Marcheselli, Maria Sessa, Giancarlo Comi, Nicoletta Checcarelli, Mario Guidotti, Davide Uccellini, Erminio Capitani, Lucia Tancredi, Marco Arnaboldi, Barbara Incorvaia, Carlo Sebastiano Tadeo, Laura Fusi, Giampiero Grampa, Giampaolo Merlini, Nadia Trobia, Giacomo Pietro Comi, Massimiliano Braga, Paolo Vitali, Pierluigi Baron, Caspar Grond-Ginsbach, Livia Candelise
BACKGROUND AND PURPOSE: Lombardia GENS is a multicentre prospective study aimed at diagnosing 5 single-gene disorders associated with stroke (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, Fabry disease, MELAS [mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes], hereditary cerebral amyloid angiopathy, and Marfan syndrome) by applying diagnostic algorithms specific for each clinically suspected disease METHODS: We enrolled a consecutive series of patients with ischemic or hemorrhagic stroke or transient ischemic attack admitted in stroke units in the Lombardia region participating in the project...
July 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27196588/comparing-ct-colonography-and-flexible-sigmoidoscopy-a-randomised-trial-within-a-population-based-screening-programme
#18
Daniele Regge, Gabriella Iussich, Nereo Segnan, Loredana Correale, Cesare Hassan, Arrigo Arrigoni, Roberto Asnaghi, Piero Bestagini, Gianmarco Bulighin, Maria Carla Cassinis, Andrea Ederle, Andrea Ferraris, Giovanni Galatola, Teresa Gallo, Giovanni Gandini, Licia Garretti, Maria Cristina Martina, Daniela Molinar, Stefania Montemezzi, Lia Morra, Massimiliano Motton, Pietro Occhipinti, Lucia Pinali, Gian Alberto Soardi, Carlo Senore
IMPORTANCE AND AIMS: The role of CT colonography (CTC) as a colorectal cancer (CRC) screening test is uncertain. The aim of our trial was to compare participation and detection rate (DR) with sigmoidoscopy (flexible sigmoidoscopy (FS)) and CTC in a screening setting. DESIGN SETTING AND PARTICIPANTS: We conducted two randomised clinical trials (RCTs). (1) Participation RCT: individuals, aged 58 years, living in Turin (Italy), were randomly assigned to be invited to FS or CTC screening; (2) detection RCT: residents in northern Italy, aged 58-60, giving their consent to recruitment, were randomly allocated to CTC or FS...
April 12, 2016: Gut
https://www.readbyqxmd.com/read/27130436/dengue-virus-immunopathogenesis-lessons-applicable-to-the-emergence-of-zika-virus
#19
REVIEW
David Olagnier, Donatella Amatore, Luciano Castiello, Matteo Ferrari, Enrico Palermo, Michael S Diamond, Anna Teresa Palamara, John Hiscott
Dengue is the leading mosquito-transmitted viral infection in the world. There are more than 390 million new infections annually; while the majority of infected individuals are asymptomatic or develop a self-limited dengue fever, up to 1 million clinical cases develop severe manifestations, including dengue hemorrhagic fever and shock syndrome, resulting in ~25,000 deaths annually, mainly in children. Gaps in our understanding of the mechanisms that contribute to dengue infection and immunopathogenesis have hampered the development of vaccines and antiviral agents...
August 28, 2016: Journal of Molecular Biology
https://www.readbyqxmd.com/read/27049613/evaluation-of-quantitative-ffn-test-in-predicting-the-risk-of-preterm-birth
#20
Michela Centra, Giuliana Coata, Elena Picchiassi, Luisa Alfonsi, Samanta Meniconi, Vittorio Bini, Maria Rosaria Di Tommaso, Mauro Cozzolino, Fabio Facchinetti, Francesca Ferrari, Maria Teresa Gervasi, Silvia Rusconi, Tullia Todros, Valentina Frisina, Nicola Rizzo, Maria Bisulli, Gian Carlo Di Renzo
OBJECTIVE: To evaluate diagnostic accuracy of quantitative fetal fibronectin (qfFN) test in predicting preterm birth (PTB) risk <34 weeks' gestation or within 14 days from testing. We explored the predictive potential of the test in five-predefined PTB risk categories based on predefined qfFN thresholds (<10, 10-49, 50-199, 200-499 and ≥500 ng/mL). METHODS: Measurement of cervicovaginal qfFN with Rapid fFN 10Q System (Hologic) in 126 women with singleton pregnancy (23-33 weeks' gestation) reporting signs and symptoms indicative of preterm labour (PTL)...
January 1, 2017: Journal of Perinatal Medicine
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