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https://www.readbyqxmd.com/read/28721538/-methamphetamine-epidemiology-clinical-importance-and-sequelae-of-abuse
#1
N Arnaud, T Thomasius
Methamphetamine (also known as meth and crystal meth) is a highly psychoactive synthetic amphetamine type stimulant, which falls under the German Federal Narcotics Law. The substance is similar to other stimulants but has distinct features with respect to psychoactive effects, clinical symptoms, user characteristics and short and long-term consequences including substance-induced problems and comorbidities. The consumption and misuse of crystal meth is still limited to certain regions in Germany; however, the substance causes significant clinical and public health concerns in the affected regions and beyond due to the associated high potential for misuse and dependence, neurotoxic and neurodegenerative effects as well as many other severe health risks...
July 18, 2017: Der Nervenarzt
https://www.readbyqxmd.com/read/28709471/acceptability-and-design-preferences-of-supervised-injection-services-among-people-who-inject-drugs-in-a-mid-sized-canadian-city
#2
Sanjana Mitra, Beth Rachlis, Ayden Scheim, Geoff Bardwell, Sean B Rourke, Thomas Kerr
BACKGROUND: Supervised injection services (SIS) have been shown to reduce the public- and individual-level harms associated with injection drug use. While SIS feasibility research has been conducted in large urban centres, little is known about the acceptability of these services among people who inject drugs (PWID) in mid-sized cities. We assessed the prevalence and correlates of willingness to use SIS as well as design and operational preferences among PWID in London, Canada. METHODS: Between March and April 2016, peer research associates administered a cross-sectional survey to PWID in London...
July 14, 2017: Harm Reduction Journal
https://www.readbyqxmd.com/read/28705259/-just-not-all-ice-users-do-that-investigating-perceptions-and-potential-harms-of-australia-s-ice-destroys-lives-campaign-in-two-studies
#3
Caitlin H Douglass, Elizabeth C Early, Cassandra J C Wright, Anna Palmer, Peter Higgs, Brendan Quinn, Paul M Dietze, Megan S C Lim
BACKGROUND: In 2015, the Australian government launched the media campaign Ice Destroys Lives targeting crystal methamphetamine use. Previous research indicates mass media campaigns may have harmful effects for people engaged in drug use. This study investigated perceptions and harms of Ice Destroys Lives among adults with a history of injecting drugs and young people. METHODS: This analysis includes data from two studies: an online questionnaire with young people and in-depth interviews with adults who use crystal methamphetamine...
July 14, 2017: Harm Reduction Journal
https://www.readbyqxmd.com/read/28586110/molecular-containers-bind-drugs-of-abuse-in-vitro-and-reverse-the-hyperlocomotive-effect-of-methamphetamine-in-rats
#4
Shweta Ganapati, Stephanie D Grabitz, Steven Murkli, Flora Scheffenbichler, Maira I Rudolph, Peter Y Zavalij, Matthias Eikermann, Lyle Isaacs
We measured the affinity of five molecular container compounds (Calabadion 1 and 2, CB[7], sulfocalix[4]arene and HP-β-CD) toward seven drugs of abuse in homogenous aqueous solution at physiological pH by various (1H NMR, UV/Vis, ITC) binding assays and find that they span from less than 102 to over 108 M-1. X-ray crystal structures of CB[7]*methamphetamine and 1*methamphetamine are reported. We find that 2, but not CB[7], is able to ameliorate the hyperlocomotive activity of rats treated with methamphetamine...
June 6, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28561211/-increasing-consumption-of-crystal-meth-in-saxony-and-its-risks-for-mother-and-child-experiences-at-a-level-i-perinatal-center-from-a-pediatric-viewpoint
#5
Jürgen Dinger, Nicole Näther, Pauline Wimberger, Ulrich S Zimmermann, Jochen Schmitt, Jörg Reichert, Mario Rüdiger
Over the past several years, the number of first-time users of methamphetamine considerably increased within the Free State of Saxony. This number also, and especially, includes women of child-bearing age and young mothers. A supportive intervention aimed at reducing the effects of drug abuse should begin in a timely way - during pregnancy at latest, but better before it. To develop an optimal care protocol for both the mother and her child, more knowledge regarding the personal conditions of the women as well as the specific features of later child development after prenatal methamphetamine exposure (PME) is vital...
April 2017: Zeitschrift Für Geburtshilfe und Neonatologie
https://www.readbyqxmd.com/read/28533098/the-current-epidemiology-of-injecting-drug-use-associated-infective-endocarditis-in-victoria-australia-in-the-midst-of-increasing-crystal-methamphetamine-use
#6
Alexandra Wright, Ohide Otome, Craig Harvey, Steve Bowe, Eugene Athan
BACKGROUND: Infective endocarditis (IE) is associated with significant mortality and morbidity despite recent advances in management. Injecting drug use (IDU) remains an important risk factor. Our aim was to evaluate the rates and patient demographics of IE and injecting drug use-associated infective endocarditis (IDU-IE) in Victoria from 2009 to 2014. METHODS: The Victorian Admitted Episode Dataset (VAED) was used to identify a population-based cohort with a diagnosis of IE and IDU-IE between 2009 and 2014 in Victoria...
May 9, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28530453/two-case-studies-illustrating-a-shared-decision-making-approach-to-illicit-methamphetamine-use-and-breastfeeding
#7
Julie Blandthorn, Katie James, Ellen Bowman, Yvonne Bonomo, Lisa H Amir
Crystal methamphetamine (MA) is a potent psycho-stimulant that is increasingly used worldwide. It is highly addictive, is often made in clandestine laboratories, and can cause serious health issues in adults. Health professionals caring for women in the perinatal period must counsel women about the health risks to infants if they are exposed to MA in breast milk. Most guidelines recommend that women who have current or recent MA use do not breastfeed. This article explores approaches to breastfeeding advice in the context of MA use...
May 22, 2017: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/28450187/nitrosoamphetamine-binding-to-myoglobin-and-hemoglobin-crystal-structure-of-the-h64a-myoglobin-nitrosoamphetamine-adduct
#8
Bing Wang, Samantha M Powell, Ye Guan, Nan Xu, Leonard M Thomas, George B Richter-Addo
N-hydroxyamphetamine (AmphNHOH) is an oxidative metabolite of amphetamine and methamphetamine. It is known to form inhibitory complexes upon binding to heme proteins. However, its interactions with myoglobin (Mb) and hemoglobin (Hb) have not been reported. We demonstrate that the reactions of AmphNHOH with ferric Mb and Hb generate the respective heme-nitrosoamphetamine derivatives characterized by UV-vis spectroscopy. We have determined the X-ray crystal structure of the H64A Mb-nitrosoamphetamine complex to 1...
July 1, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28448903/violence-trauma-and-living-with-hiv-longitudinal-predictors-of-initiating-crystal-methamphetamine-injection-among-sex-workers
#9
Elena Argento, Steffanie A Strathdee, Shira Goldenberg, Melissa Braschel, Julio Montaner, Kate Shannon
BACKGROUND: Despite rapid increases in crystal methamphetamine (CM) use worldwide and established gendered patterns of use, empirical research on CM injection initiation among sex workers is limited. Given the wide range of harms associated with CM, alongside stimulant effects including sexual dis-inhibition and prolonged awake-ness, this study aimed to longitudinally investigate socio-structural predictors of initiating CM injection among sex workers in Vancouver, Canada. METHODS: Data (2010-2014) were drawn from a community-based cohort of women sex workers: AESHA (An Evaluation of Sex Workers Health Access)...
June 1, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28445899/evidence-based-guidelines-for-the-pharmacologic-management-of-methamphetamine-dependence-relapse-prevention-chronic-methamphetamine-related-and-comorbid-psychiatric-disorders-in-post-acute-settings
#10
Roland Härtel-Petri, Anne Krampe-Scheidler, Wolf-Dietrich Braunwarth, Ursula Havemann-Reinecke, Peter Jeschke, Winfried Looser, Stephan Mühlig, Ingo Schäfer, Norbert Scherbaum, Lydia Bothe, Corinna Schaefer, Willem Hamdorf
The increasing abuse of the street drug crystal meth (methamphetamine) in many countries worldwide has resulted in a growing demand to treat patients who have acquired a methamphetamine-related disorder. The results of a systematic literature search which led to the consensus-based recommendations by the Working Group of the German Agency for Quality in Medicine (Ärztliches Zentrum für Qualität in der Medizin - ÄZQ) are presented. Pharmacological treatments were reviewed in 58 out of the 103 publications included...
May 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/28379111/lifetime-doctor-diagnosed-mental-health-conditions-and-current-substance-use-among-gay-and-bisexual-men-living-in-vancouver-canada
#11
Nathan J Lachowsky, Joshun J S Dulai, Zishan Cui, Paul Sereda, Ashleigh Rich, Thomas L Patterson, Trevor T Corneil, Julio S G Montaner, Eric A Roth, Robert S Hogg, David M Moore
BACKGROUND: Studies have found that gay, bisexual, and other men who have sex with men (GBM) have higher rates of mental health conditions and substance use than heterosexual men, but are limited by issues of representativeness. OBJECTIVES: To determine the prevalence and correlates of mental health disorders among GBM in Metro Vancouver, Canada. METHODS: From 2012 to 2014, the Momentum Health Study recruited GBM (≥16 years) via respondent-driven sampling (RDS) to estimate population parameters...
May 12, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28351079/editorial-to-methamphetamine-crystal-meth-and-new-psychoactive-substances
#12
Ulrich S Zimmermann
No abstract text is available yet for this article.
May 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/28347349/use-of-crystal-methamphetamine-among-male-adolescents-in-cape-town-south-africa-caregivers-experiences
#13
Kwaku Oppong Asante, Antonio G Lentoor
BACKGROUND: Against the background that crystal methamphetamine (colloquially known as "tik") is extensively used by the emerging working class Coloured youth in Cape Town, South Africa, this exploratory qualitative study was conducted to explore the experience of mothers whose children use methamphetamine. METHODS: The researchers conducted one-to-one semi-structured in-depth interviews with sixteen (16) purposively selected caregivers (mothers) whose sons use methamphetamine...
March 27, 2017: Substance Abuse Treatment, Prevention, and Policy
https://www.readbyqxmd.com/read/28222753/evaluation-of-blood-lead-level-in-methamphetamine-users-in-tehran
#14
Babak Mostafazadeh, Shahin Shadnia, Mohammad Ali Tavakkoli, Hamid Reza Khoddami Vishteh
BACKGROUND: Given the increasing number of lead poisoning in opioids users and since no study has been conducted so far to review lead poisoning in methamphetamine (crystal) users, this study aimed to investigate blood lead level in methamphetamine addicts. METHODS: This study was conducted on 20 patients with methamphetamine poisoning and their blood lead level was measured. The subjects were selected from among patients with a history of continuous use of methamphetamine, without a history of using opiates in the past 6 months confirmed by a negative urine tests, and without a history of heavy metal poisoning...
February 22, 2017: Substance Abuse Treatment, Prevention, and Policy
https://www.readbyqxmd.com/read/28158885/breaking-bad-delirium-methamphetamine-and-boric-acid-toxicity-with-hallucinations-and-pseudosepsis
#15
Kayla Johnson, Joanna L Stollings, E Wesley Ely
OBJECTIVES: A 30-year-old patient presented with hallucinations and profound shock. He was initially misdiagnosed as having severe sepsis; once ingestions were considered, he was diagnosed as potentially having arsenic toxicity. SUMMARY: The clinical story reveals many instructional lessons that could aid in the evaluation and management of future patients. This man presented with large amounts of blue crystals around his nose and lips from inhaling and eating boric acid (an ant poison) so he could, as he put it, kill the ants "pouring into my mouth and nose and up into my brain...
February 2017: Southern Medical Journal
https://www.readbyqxmd.com/read/28117545/recreational-drug-use-and-chemsex-among-hiv-infected-in-patients-a-unique-screening-opportunity
#16
E R Elliot, S Singh, S Tyebally, K Gedela, M Nelson
OBJECTIVES: While a high rate of recreational drug use (RDU) has been documented among HIV-infected out-patients, particularly in men who have sex with men (MSM), there is a distinct lack of data for HIV-infected in-patients. Hospital admission offers a unique opportunity to engage drug users. We aimed to establish and characterize RDU among new admissions to a large dedicated London HIV in-patient unit and compare it to RDU among general medical admissions to inform clinical pathways...
January 24, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28092450/preintervention-profiles-of-information-motivational-and-behavioral-self-efficacy-for-methamphetamine-use-and-hiv-medication-adherence-among-gay-and-bisexual-men
#17
Tyrel J Starks, Brett M Millar, Jonathan M Lassiter, Jeffrey T Parsons
Although rates of crystal methamphetamine use in the United States have fallen from their peak in the mid-2000s, use remains a major public health concern, which disproportionately affects gay and bisexual men (GBM). It poses a particular challenge for HIV-positive men, for whom it has been linked to medication adherence problems as well as compromised immune function. Although the information, motivation, and behavioral skills (IMB) model has been widely used to conceptualize health behavior, little is known about GBM's initial levels of information, motivation, and behavioral self-efficacy to improve HIV medication adherence and to reduce crystal methamphetamine use at the outset of treatment...
February 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/28081482/following-lives-undergoing-change-flux-study-implementation-and-baseline-prevalence-of-drug-use-in-an-online-cohort-study-of-gay-and-bisexual-men-in-australia
#18
Mohamed A Hammoud, Fengyi Jin, Louisa Degenhardt, Toby Lea, Lisa Maher, Jeffrey Grierson, Brent Mackie, Marcus Pastorelli, Colin Batrouney, Nicky Bath, Jack Bradley, Garrett P Prestage
BACKGROUND: Drug use among gay and bisexual men (GBM) is higher than most populations. The use of crystal methamphetamine, erectile dysfunction medication (EDM), and amyl nitrite have been associated with sexual risk behaviour and HIV infection among gay and bisexual men (GBM). OBJECTIVE: This paper describes an online prospective observational study of licit and illicit drug use among GBM and explores baseline prevalence of drug use in this sample. Capturing these data poses challenges as participants are required to disclose potentially illegal behaviours in a geographically dispersed country...
January 9, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/27936336/experiences-of-health-professionals-caring-for-people-presenting-to-the-emergency-department-after-taking-crystal-methamphetamine-ice
#19
Michelle Cleary, Debra Jackson, Cindy Woods, Rachel Kornhaber, Jan Sayers, Kim Usher
Globally, addiction to "ICE" (crystal methamphetamine) is increasing and presents emergency health care services personnel with a number of challenges. This paper reports the first of two major themes arising from a qualitative study investigating health professionals' experiences' managing people presenting to the Emergency Department (ED) after taking "ICE." The theme "Caring for people who use 'ICE' when presenting to EDs" comprises five subthemes. These are: (a) expecting the unexpected: "they're just off their heads"; (b) complexity of care: "underlying trauma and emotional dysregulation";...
January 2017: Issues in Mental Health Nursing
https://www.readbyqxmd.com/read/27868256/ice-and-the-outback-patterns-and-prevalence-of-methamphetamine-use-in-rural-australia
#20
Ann Roche, Alice McEntee
OBJECTIVE: This study investigated whether lifetime and recent methamphetamine use (including crystal methamphetamine) differed among city, regional and rural residents and whether particular subpopulations were more at-risk. DESIGN: Secondary analyses of the last three National Drug Strategy Household Surveys and corresponding Alcohol and Other Drug Treatment Services National Minimum Data Sets (AODTS NMDS). SETTING: Australian general population...
November 21, 2016: Australian Journal of Rural Health
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