keyword
https://read.qxmd.com/read/38544685/fertility-and-sexual-activity-in-patients-with-triple-a-syndrome
#1
JOURNAL ARTICLE
Katja K Dumic, Claudine Heinrichs, Katrin Koehler, Angela Huebner, Miroslav Dumic, Vesna Kusec, Tina Dusek, Friederike Quitter
OBJECTIVE: Triple A syndrome, caused by autosomal recessively inherited mutations in the AAAS gene is characterized by alacrima, achalasia, adrenal insufficiency, and neurological impairment. To the best of our knowledge, no patients of both sexes have been reported to have offspring. Our aim was to assess the causes of infertility in male patients with this multisystemic syndrome, and to present a female patient that spontaneously conceived a child. DESIGN: Cross-sectional study...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38544672/chronic-demyelination-interferes-with-normal-spermatogenesis-in-cuprizone-intoxicant-c57-bl-6-mice-an-experimental-study
#2
JOURNAL ARTICLE
Arezoo Dorikhani, Ameneh Omidi, Mansoureh Movahedin, Iman Halvaei
BACKGROUND: Due to myelin and axonal insults in multiple sclerosis individuals, motor coordination problems and endocrine imbalance may develop. OBJECTIVE: This study aims to evaluate the role of chronic demyelination on the hypothalamic-pituitary-gonadal axis in the mouse model of multiple sclerosis. MATERIALS AND METHODS: 20 adult C57/BL6 male mice were divided into 2 groups (n = 10/each) as follows: the control group (CONT) received a regular diet for 17 wk; and the experimental group (cuprizone [CPZ]) was fed with 0...
January 2024: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://read.qxmd.com/read/38543190/addressing-the-adme-challenges-of-compound-loss-in-a-pdms-based-gut-on-chip-microphysiological-system
#3
JOURNAL ARTICLE
Patrick Carius, Ferdinand Anton Weinelt, Chris Cantow, Markus Holstein, Aaron M Teitelbaum, Yunhai Cui
Microphysiological systems (MPSs) are promising in vitro technologies for physiologically relevant predictions of the human absorption, distribution, metabolism, and excretion (ADME) properties of drug candidates. However, polydimethylsiloxane (PDMS), a common material used in MPSs, can both adsorb and absorb small molecules, thereby compromising experimental results. This study aimed to evaluate the feasibility of using the PDMS-based Emulate gut-on-chip to determine the first-pass intestinal drug clearance...
February 20, 2024: Pharmaceutics
https://read.qxmd.com/read/38543118/effect-of-arthrospira-spirulina-maxima-on-cadmium-chloride-induced-alterations-in-sexual-behavior-and-fertility-in-male-wistar-rats
#4
JOURNAL ARTICLE
Galván-Colorado Candelaria, García-Rodríguez Rosa Virginia, Mojica-Villegas María Angélica, García-Martínez Yuliana, Cristóbal-Luna José Melesio, Chamorro-Cevallos Germán
Chronic exposure to potentially toxic elements (PTEs) such as cadmium (Cd) leads to male reproductive toxicity through the generation of oxidative stress. Spirulina Arthrospira maxima (AM) is a cyanobacterium that has been consumed since ancient times for its high nutritional value, and in recent years for its antiviral, hepatoprotective, hypoglycemic, anticancer, and antioxidant effects, among others. This study aimed to evaluate the effects of AM against the damage to reproductive health induced by Cd. A total of 48 10-week-old sexually experienced male Wistar rats were distributed in five groups ( n = 8): control; vehicle (tween-water); cadmium chloride (CdCl2 ) 5 mg/kg; and three doses of AM (100, 200 and 400 mg/kg) + CdCl2 5 mg/kg...
March 3, 2024: Pharmaceuticals
https://read.qxmd.com/read/38543108/anthocyanins-from-lycium-ruthenicum-murray-mitigate-cadmium-induced-oxidative-stress-and-testicular-toxicity-by-activating-the-keap1-nrf2-signaling-pathway
#5
JOURNAL ARTICLE
Mingran Dong, Juan Lu, Hongwei Xue, Yang Lou, Shuyang Li, Tao Liu, Zimian Ding, Xi Chen
Cadmium (Cd) is a hazardous heavy metal environmental pollutant that has carcinogenic, teratogenic, and mutagenic properties. Excessive exposure to Cd can induce oxidative stress, which greatly harms the male reproductive system. Anthocyanins have remarkable antioxidative, anti-inflammatory, and anti-stress properties. In this study, we investigated the effects of anthocyanins and the underlying mechanisms through which anthocyanins mitigate Cd-induced reproductive damage. We isolated and purified Lycium ruthenicum Murray anthocyanin extract (LAE) and performed UHPLC-MS/MS to identify 30 different anthocyanins...
March 1, 2024: Pharmaceuticals
https://read.qxmd.com/read/38542516/gender-specific-renoprotective-pathways-in-%C3%AE-mupa-transgenic-mice-subjected-to-acute-kidney-injury
#6
JOURNAL ARTICLE
Heba Abd Alkhaleq, Shadi Hamoud, Israel Hacker, Tony Karram, Ahmad Fokra, Aviva Kabala, Zaid Abassi
Acute kidney injury (AKI) is a serious health concern with high morbidity and high mortality worldwide. Recently, sexual dimorphism has become increasingly recognized as a factor influencing the severity of the disease. This study explores the gender-specific renoprotective pathways in αMUPA transgenic mice subjected to AKI. αMUPA transgenic male and female mice were subjected to ischemia-reperfusion (I/R)-AKI in the presence or absence of orchiectomy, oophorectomy, and L-NAME administration. Blood samples and kidneys were harvested 48 h following AKI for the biomarkers of kidney function, renal injury, inflammatory response and intracellular pathway sensing of or responding to AKI...
March 21, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542167/effect-of-gnrh-active-immunisation-on-reproductive-performance-of-male-sprague-dawley-rats
#7
JOURNAL ARTICLE
Cheng-Qi Zhang, Shuang-Shuang Li, Bo Hu, Li-Wen Xu, Jia-Jia Liu, Ya-Jie Sun, Xue Bai
To investigate the effect of active immunisation with gonadotropin-releasing hormone (GnRH) on the reproductive function in male Sprague Dawley (SD) rats, 24 42-day-old rats were randomly assigned to treatment with GnRH6-MAP, GnRH-OVA, a surgical castration group, and a blank control group. Each rat in the treatment groups was intramuscularly injected at 6, 8, and 10 weeks of age. The serum concentrations of testosterone (T), follicle-stimulating hormone (FSH), luteinising hormone (LH), and anti-GnRH antibodies were determined using enzyme-linked immunosorbent assays...
March 11, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38541685/prevalence-and-clinical-management-of-adrenal-tumour-related-hyperandrogenism-a-narrative-review
#8
REVIEW
Sanja Medenica, Dusan Zivanovic, Domenico Milardi, Carmine Bruno, Ljubica Batkoska, Emanuela Traini, Alfredo Pontecorvi
Hyperandrogenism is a condition in which the levels of androgen hormones in the blood are significantly increased and could be of an adrenal or ovarian origin. The adrenal androgens, normally secreted by the zona reticularis, are steroid hormones with weak androgen activity. The causes of hyperandrogenism are diverse and could be endogenous and exogenous. Androgen excess affecting different tissues and organs results in clinical features such as acne, hirsutism, virilization, and reproductive dysfunction such as oligomenorrhoea/amenorrhoea...
March 9, 2024: Life
https://read.qxmd.com/read/38541275/association-of-endogenous-testosterone-with-physical-fitness-measures-during-firefighter-occupational-health-evaluations
#9
JOURNAL ARTICLE
Luiz Guilherme Grossi Porto, Edgard M K V K Soares, Sushant M Ranadive, Adriana Lofrano-Porto, Denise L Smith
Firefighting is a physically demanding profession associated with unacceptably high on-duty cardiovascular mortality. Low endogenous total testosterone (TT) is an emerging cardiometabolic (CM) risk factor in men, but limited data exists on its interactions with physical fitness (PF). Data from occupational health and fitness assessments of 301 male career firefighters (FFs) were analyzed. TT was categorized as low (<264 ng/dL), borderline (264-399 ng/dL), and reference (400-916 ng/dL). PF tests included cardiorespiratory fitness (submaximal treadmill), body fat percentage (BF%), push-ups, plank, and handgrip strength assessments...
February 27, 2024: International Journal of Environmental Research and Public Health
https://read.qxmd.com/read/38541016/the-correlation-between-sex-hormone-binding-globulin-and-clinical-characteristics-according-to-anti-m%C3%A3-llerian-hormone-in-women-with-regular-menstrual-cycles-a-prospective-study
#10
JOURNAL ARTICLE
Jihyun Keum, Yong Jin Kim, Sae Kyung Choi, Won Moo Lee, Jaeman Bae
BACKGROUND: Polycystic ovarian syndrome (PCOS) can be diagnosed when the anti-Müllerian hormone (AMH) levels are high, but in clinic, women who do not meet the diagnosis of PCOS but have elevated AMH levels are often seen. This study aimed to compare the differences in menstrual cycle patterns and hormone levels in women with regular menstrual cycles, but not PCOS, by dividing them into high and low AMH groups. MATERIAL AND METHODS: This multicenter prospective study included 68 healthy women...
February 29, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38540126/the-hormonal-background-of-hair-loss-in-non-scarring-alopecias
#11
REVIEW
Barbara Owecka, Agata Tomaszewska, Krzysztof Dobrzeniecki, Maciej Owecki
Hair loss is a common clinical condition connected with serious psychological distress and reduced quality of life. Hormones play an essential role in the regulation of the hair growth cycle. This review focuses on the hormonal background of hair loss, including pathophysiology, underlying endocrine disorders, and possible treatment options for alopecia. In particular, the role of androgens, including dihydrotestosterone (DHT), testosterone (T), androstenedione (A4), dehydroepiandrosterone (DHEA), and its sulfate (DHEAS), has been studied in the context of androgenetic alopecia...
February 24, 2024: Biomedicines
https://read.qxmd.com/read/38540097/genistein-and-sex-hormone-supplementation-modulated-hepatic-ppar%C3%AE-%C3%AE-and-%C3%AE-subtypes-and-stat1-expressions-in-a-nash-rat-model-with-bilateral-orchidectomy
#12
JOURNAL ARTICLE
Fatist Okrit, Maneerat Chayanupatkul, Prasong Siriviriyakul, Natcha Wanpiyarat, Duangporn Werawatganon
Nonalcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease (NAFLD) that is characterized by hepatic inflammation and steatosis. Currently, limited data exist regarding the risk of NASH in transgender women and the treatment options for this particular population. The use of testosterone supplementation is unfavorable for transgender women, and estrogen supplementation is linked to an increased risk of breast cancer; thus, an isoflavone derivative compound known as "genistein" could serve as a viable substitute for a hormone supplement in this context...
February 21, 2024: Biomedicines
https://read.qxmd.com/read/38539974/effect-of-day-length-on-growth-and-gonadal-development-in-meishan-male-pigs
#13
JOURNAL ARTICLE
Naisheng Lu, Hao Yuan, Xueyuan Jiang, Hulong Lei, Wen Yao, Peng Jia, Dong Xia
Day length is a critical environmental factor for regulating animal growth and development. This study aimed to investigate the effects of different day lengths on the developmental changes of growth parameters, testicular sizes, testosterone secretion in Meishan male pigs, and steroidogenesis proteins and melatonin receptors. Fourteen Meishan male pigs (10 weeks (wks) of age) with the same parity, paired in litter and body weight (BW), were evenly allocated into a short-day-length group (SDL, 10 light/14 dark) and long-day-length group (LDL, 14 light/10 dark)...
March 13, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38539883/two-generation-toxicity-study-of-the-antioxidant-compound-propyl-propane-thiosulfonate-ptso
#14
JOURNAL ARTICLE
Antonio Cascajosa-Lira, Remedios Guzmán-Guillén, Silvia Pichardo, Alberto Baños, Jose M de la Torre, Nahum Ayala-Soldado, M Rosario Moyano-Salvago, Isabel Ortiz-Jaraba, Ana M Cameán, Angeles Jos
Propyl-propane thiosulfonate (PTSO), an antioxidant organosulfur compound present in the genus Allium , has become a potential natural additive for food and feed, as well as a possible biopesticide for pest control in plants. A toxicological assessment is necessary to verify its safety for livestock, consumers, and the environment. As part of the risk assessment of PTSO, this study was designed to explore its potential reproductive toxicity in mice following the OECD 416 guideline. The investigation spans two generations to comprehensively evaluate potential reproductive, teratogenic, and hereditary effects...
March 15, 2024: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/38539664/the-association-among-hypothalamic-subnits-gonadotropic-and-sex-hormone-plasmas-levels-in-alzheimer-s-disease
#15
JOURNAL ARTICLE
Edward Ofori, Anamaria Solis, Nahid Punjani, On Behalf Of The Alzheimer's Disease Neuroimaging Initiative
This study investigates the sex-specific role of the Hypothalamic-Pituitary-Gonadal axis in Alzheimer's disease progression, utilizing ADNI1 data for 493 individuals, analyzing plasma levels of gonadotropic and sex hormones, and examining neurodegeneration-related brain structures. We assessed plasma levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), progesterone (P4), and testosterone (T), along with volumetric measures of the hippocampus, entorhinal cortex, and hypothalamic subunits, to explore their correlation with Alzheimer's disease markers across different cognitive statuses and sexes...
March 14, 2024: Brain Sciences
https://read.qxmd.com/read/38539511/immune-checkpoint-inhibitors-and-male-fertility-should-fertility-preservation-options-be-considered-before-treatment
#16
REVIEW
Elissavet Ntemou, Emily Delgouffe, Ellen Goossens
In recent years, immune checkpoint inhibitors (ICIs) have become a viable option for many cancer patients, including specific subgroups of pediatric patients. Despite their efficiency in treating different types of cancer, ICIs are responsible for a number of immune-related adverse events, including inflammatory toxicities, that can affect several organs. However, our knowledge of the impact of ICIs on the testis and male fertility is limited. It is possible that ICI treatment affects testicular function and spermatogenesis either directly or indirectly (or both)...
March 17, 2024: Cancers
https://read.qxmd.com/read/38538260/melatonin-alleviates-bpa-induced-testicular-apoptosis-and-endoplasmic-reticulum-stress
#17
JOURNAL ARTICLE
Qi Qi, Lei Feng, Jingjing Liu, Da Xu, Guoqing Wang, Xiaoyan Pan
BACKGROUND: The impact of melatonin on bisphenol A (BPA)-induced testicular apoptosis and endoplasmic reticulum (ER) stress was explored. METHODS: The mice received BPA (50 mg/kg) by gavage for 30 days while being injected with 20 mg/kg melatonin. Protein expressions were detected with western blotting. The Terminal Deoxynucleotidyl Transferase dUTP Nick End Labeling (TUNEL) assay measured testicular cell apoptosis. Testosterone was quantified by employing enzyme-linked immunosorbent assay (ELISA)...
March 8, 2024: Frontiers in Bioscience (Landmark Edition)
https://read.qxmd.com/read/38536657/increased-risk-of-erythrocytosis-in-men-with-type-2-diabetes-treated-with-combined-sodium-glucose-cotransporter-2-inhibitor-and-testosterone-replacement-therapy
#18
JOURNAL ARTICLE
A R Gosmanov, D E Gemoets, K A Schumacher
PURPOSE: In clinical trials, sodium-glucose cotransporter-2 inhibitors (SGLT-2i) and testosterone replacement therapy (TRT) were shown to stimulate red blood cell production. Little is known if combination therapy poses risk of erythrocytosis in real world clinical practice. METHODS: This was a retrospective nationwide cohort study of US Veterans with type 2 diabetes (T2D) and baseline hematocrit between 38 and 50% who were prescribed SGLT-2i and/or TRT between 3/2013 and 10/2022 and had adequate adherence based on the proportion of days covered > 80%...
March 27, 2024: Journal of Endocrinological Investigation
https://read.qxmd.com/read/38536548/bone-mineral-density-in-adults-growth-hormone-deficiency-with-different-ages-of-onset-a-real-world-retrospective-study
#19
JOURNAL ARTICLE
Hongbo Yang, Meiping Chen, Hanyuan Xu, Yunfeng Zhen, Yuelun Zhang, Linjie Wang, Lian Duan, Fengying Gong, Huijuan Zhu, Hui Pan
PURPOSE: Bone mineral density (BMD) impairment is one of the critical factors for long-term quality of life in adults growth hormone deficiency (AGHD). This study aims to investigate the annual changes in BMD in AGHD patients with different ages of onset and to identify predicting factors that influence BMD. METHODS: AGHD patients (n = 160) with available data for 4 years follow-up from a major tertiary medical center in China were retrospectively included (110 [68...
March 27, 2024: Endocrine
https://read.qxmd.com/read/38536491/no-evidence-for-a-causal-contribution-of-bioavailable-testosterone-to-adhd-in-sex-combined-and-sex-specific-two-sample-mendelian-randomization-studies
#20
JOURNAL ARTICLE
Lars Dinkelbach, Triinu Peters, Corinna Grasemann, Johannes Hebebrand, Anke Hinney, Raphael Hirtz
The higher prevalence of attention-deficit/hyperactivity disorder (ADHD) in males raises the question of whether testosterone is implicated in ADHD risk. However, cross-sectional studies did not identify an association between ADHD and testosterone levels. Mendelian randomization (MR) studies can overcome limitations inherent to association studies, especially of reverse causation and residual confounding. In the current study, sex-combined and sex-specific two-sample MR analyses were conducted to address whether testosterone has a causal influence on ADHD risk...
March 27, 2024: European Child & Adolescent Psychiatry
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