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https://www.readbyqxmd.com/read/27926439/competition-testosterone-and-adult-neurobehavioral-plasticity
#1
A B Losecaat Vermeer, I Riečanský, C Eisenegger
Motivation in performance is often measured via competitions. Winning a competition has been found to increase the motivation to perform in subsequent competitions. One potential neurobiological mechanism that regulates the motivation to compete involves sex hormones, such as the steroids testosterone and estradiol. A wealth of studies in both nonhuman animals and humans have shown that a rise in testosterone levels before and after winning a competition enhances the motivation to compete. There is strong evidence for acute behavioral effects in response to steroid hormones...
2016: Progress in Brain Research
https://www.readbyqxmd.com/read/27924836/endogenous-testosterone-is-associated-with-lower-amygdala-reactivity-to-angry-faces-and-reduced-aggressive-behavior-in-healthy-young-women
#2
Macià Buades-Rotger, Christin Engelke, Frederike Beyer, Brian G Keevil, Georg Brabant, Ulrike M Krämer
Testosterone and cortisol have been proposed to influence aggressive behavior by altering the neural processing of facial threat signals. However, this has not been investigated in direct social interactions. Here, we explored the joint impact of testosterone, cortisol, and brain reactivity to anger expressions on women's reactive aggression in the Social Threat Aggression Paradigm (STAP). The STAP is a competitive reaction time task in which the purported opponent displays either an angry or a neutral facial expression at the beginning of each trial and delivers increasingly loud sound blasts to the participants, successfully provoking them...
December 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27924509/inhibitory-effect-of-diosgenin-on-experimentally-induced-benign-prostatic-hyperplasia-in-rats
#3
Jing Chen, Huai-Fen Zhang, Chao-Mei Xiong, Jin-Lan Ruan
This study investigated the effect of diosgenin, a natural sapogenin possessing various pharmacological activities, on benign prostatic hyperplasia (BPH) in rats and the possible mechanisms. BPH was established in the castrated rats by subcutaneous injection of testosterone propionate. Animals were randomly divided into four groups (n=10 each): model group (0.5% sodium carboxymethyl cellulose); positive control group (3 mg/kg finasteride); two diosgenin groups (50 and 100 mg/kg). The drugs were intragastricaly given in each group for consecutive 3 weeks...
December 2016: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/27923967/multi-institutional-survey-of-medical-treatment-for-late-onset-hypogonadism-in-japan
#4
Hisanori Taniguchi, Tadashi Matsuda
The adequate criteria for late-onset hypogonadism (LOH) diagnosis, including serum testosterone levels, type (total or free testosterone) and duration of androgen replacement therapy, and evaluations of treatment effectiveness remain controversial. To evaluate the current status of medical treatment for LOH in Japan, the first nationwide survey were performed. A total of 35 questionnaires answered by urologists in high-volume facilities were analyzed. The median numbers of patients with hypogonadism-related symptoms per month were 10...
December 5, 2016: American Journal of Men's Health
https://www.readbyqxmd.com/read/27923708/acth-modulation-on-corticosterone-melatonin-testosterone-and-innate-immune-response-in-the-tree-frog-hypsiboas-faber
#5
Adriana Maria Giorgi Barsotti, Vania Regina de Assis, Stefanny Christie Monteiro Titon, Braz Titon Junior, Zulma Felisbina da Silva Ferreira, Fernando Ribeiro Gomes
The modulation exerted by glucocorticoids in physiological responses to stressors is essential for maintaining short-term homeostasis. However, highly frequent and/or prolonged activation of the hypothalamic-pituitary-adrenal/interrenal axis may inhibit processes that are important to long-term fitness and health, including reproduction and immunocompetence. The present study evaluates the response to adrenocorticotropic hormone (ACTH) injection in the adult male tree frog, Hypsiboas faber, as indicated by levels of plasma corticosterone (CORT), plasma testosterone (T), ocular melatonin (MEL), hematocrit and immune functioning (total leukocyte count and bacterial killing ability against Escherichia coli)...
December 3, 2016: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/27923611/cumulative-effects-of-antiandrogenic-chemical-mixtures-and-their-relevance-to-human-health-risk-assessment
#6
REVIEW
Kembra L Howdeshell, Andrew K Hotchkiss, L Earl Gray
Toxicological studies of defined chemical mixtures assist human health risk assessment by establishing how chemicals interact with one another to induce an effect. This paper reviews how antiandrogenic chemical mixtures can alter reproductive tract development in rats with a focus on the reproductive toxicant phthalates. The reviewed studies compare observed mixture data to mathematical mixture model predictions based on dose addition or response addition to determine how the individual chemicals in a mixture interact (e...
November 19, 2016: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/27923406/ameliorative-effects-of-rutin-against-metabolic-biochemical-and-hormonal-disturbances-in-polycystic-ovary-syndrome-in-rats
#7
Sarwat Jahan, Faryal Munir, Suhail Razak, Anam Mehboob, Qurat Ul Ain, Hizb Ullah, Tayyaba Afsar, Ghazala Shaheen, Ali Almajwal
BACKGROUND: Polycystic ovary syndrome (PCOS) is the most prevalent endocrinopathy in women of reproductive age. The study was commenced to assess the favorable effects of Rutin against metabolic, biochemical, histological, and androgenic aspects of polycystic ovary syndrome in rats. METHODS: Female Sprague-Dawley rats were administered letrozole (1 mg/kg) per orally (p.o) for a period of 21 days for the induction of PCOS, followed by dose of rutin (100 mg/kg and 150 mg/kg, p...
December 7, 2016: Journal of Ovarian Research
https://www.readbyqxmd.com/read/27923166/a-comparative-systematic-review-of-yasmin-drospirenone-pill-versus-standard-treatment-options-for-symptoms-of-polycystic-ovary-syndrome
#8
REVIEW
Jing Li, Jing Ren, Wenxia Sun
OBJECTIVES: To systematically review the impact of Yasmin (drospirenone pill) compares with other standard treatments for symptoms of Polycystic Ovary Syndrome (PCOS). STUDY DESIGN: The relevant studies of the randomized controlled trials in women with PCOS treated with drospirenone were retrieved and the systematic evaluation was conducted. RESULTS: Eighteen articles were included. Compared with drospirenone (DRSP) monotherapy, DRSP plus metformin was better in reducing body mass index (BMI), luteinizing hormone (LH) and low-density lipoprotein cholesterol (LDL-C)...
November 16, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27921326/correlation-of-genetic-results-with-testicular-histology-hormones-and-sperm-retrieval-in-nonobstructive-azoospermia-patients-with-testis-biopsy
#9
W Liu, X Gao, G Ma, L Yan, T Chen, T Li, R-M Yu, J-L Ma
To investigate the frequency and types of genetic results in different testicular histology of patients with nonobstructive azoospermia (NOA), and correlated with hormones and sperm retrieval (SR), a retrospective study was conducted in 286 Chinese NOA patients who underwent testis biopsy and 100 age-matched fertile men as the control group. Chromosome karyotype analyses were performed by the peripheral blood chromosome G-band detection method. Screening of Y chromosome microdeletions of azoospermia factor (AZF) region was performed by polymerase chain reaction (PCR) amplification of 11 sequence-tagged sites (STS)...
December 6, 2016: Andrologia
https://www.readbyqxmd.com/read/27921086/ovarian-and-uterine-alterations-following-forced-swimming-an-immunohistochemical-study
#10
Seyedeh Nazanin Seyed Saadat, Fahimeh Mohammadghasemi, Hannan Ebrahimi, Hanieh Rafati Sajedi, Gelayol Chatrnour
BACKGROUND: Physical exercise is known to be a stressor stimulus that leads to reproductive disruption. OBJECTIVE: The aim of this study was to evaluate the effect of forced swimming on the uterus and ovaries in mice. MATERIALS AND METHODS: Adult mice (N=24) were divided into the following three groups: A, control; B, swimming in water (10(o)C); and C, swimming in water (23(o)C). Swimmers swam for 5 min daily for 5 consecutive days/ wk during 2 wks...
October 2016: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/27920032/overselling-hysteria-the-role-of-the-media-and-medical-journals-in-promoting-questionable-risks-a-case-study-of-the-testosterone-controversy
#11
Abdulmaged M Traish, Jay C Vance, Abraham Morgentaler
No abstract text is available yet for this article.
December 5, 2016: EMBO Reports
https://www.readbyqxmd.com/read/27919363/the-effects-of-statin-treatment-on-adrenal-and-sexual-function-and-nitric-oxide-levels-in-hypercholesterolemic-male-patients-treated-with-a-statin
#12
Osman Baspınar, Fahri Bayram, Selda Korkmaz, Murat Aksu, Derya Kocer, Oğuzhan Sıtkı Dizdar, Yasin Simsek, Peter P Toth
BACKGROUND: Erectile dysfunction complaints among men treated with a statin are not uncommon. OBJECTIVES: To evaluate the effect of lowering low-density lipoprotein cholesterol (LDL-C) to target levels using varying doses of atorvastatin therapy in hypercholesterolemic male patients on adrenocortical hormones, sexual functions, and serum nitric oxide (NO) levels. METHODS: Eleven hypercholesterolemic male patients who had LDL-C levels greater than 160 mg/dL were included in the study and 11 healthy male individuals served as controls...
November 2016: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/27918137/highlight-on-engineering-mycobacterium-smegmatis-for-testosterone-production
#13
Utkarsh Sood, Yogendra Singh, Mallikarjun Shakarad, Rup Lal
No abstract text is available yet for this article.
December 5, 2016: Microbial Biotechnology
https://www.readbyqxmd.com/read/27917368/sex-steroid-hormone-single-nucleotide-polymorphisms-pesticide-use-and-the-risk-of-prostate-cancer-a-nested-case-control-study-within-the-agricultural-health-study
#14
Carol H Christensen, Kathryn Hughes Barry, Gabriella Andreotti, Michael C R Alavanja, Michael B Cook, Scott P Kelly, Laurie A Burdett, Meredith Yeager, Laura E Beane Freeman, Sonja I Berndt, Stella Koutros
Experimental and epidemiologic investigations suggest that certain pesticides may alter sex steroid hormone synthesis, metabolism or regulation, and the risk of hormone-related cancers. Here, we evaluated whether single-nucleotide polymorphisms (SNPs) involved in hormone homeostasis alter the effect of pesticide exposure on prostate cancer risk. We evaluated pesticide-SNP interactions between 39 pesticides and SNPs with respect to prostate cancer among 776 cases and 1,444 controls nested in the Agricultural Health Study cohort...
2016: Frontiers in Oncology
https://www.readbyqxmd.com/read/27917130/commentary-facial-width-to-height-ratio-fwhr-is-not-associated-with-adolescent-testosterone-levels
#15
COMMENT
Keith M Welker, Brian M Bird, Steven Arnocky
No abstract text is available yet for this article.
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27916832/anthropometric-measurements-serum-reproductive-hormonal-levels-and-sexual-development-among-boys-in-the-rural-western-cape-south-africa
#16
Jun Mao, Mohamed Aqiel Dalvie
Data on growth and sexual maturation among boys from the rural Western Cape in South Africa is limited. A cross-sectional study of 269 school boys was conducted testing for serum luteinizing hormone (LH), follicle stimulating hormone (FSH), testosterone, sex hormone binding globulin (SHBG) and estradiol (E2); height, weight and body mass index (BMI); sexual maturity (using Tanner Stages) and a questionnaire (demographic and medical history). The median age at pubertal onset (Tanner Stage 2) and Tanner Stage 5 was 11...
November 29, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27916394/hypoactive-sexual-desire-disorder-international-society-for-the-study-of-women-s-sexual-health-isswsh-expert-consensus-panel-review
#17
REVIEW
Irwin Goldstein, Noel N Kim, Anita H Clayton, Leonard R DeRogatis, Annamaria Giraldi, Sharon J Parish, James Pfaus, James A Simon, Sheryl A Kingsberg, Cindy Meston, Stephen M Stahl, Kim Wallen, Roisin Worsley
The objective of the International Society for the Study of Women's Sexual Health expert consensus panel was to develop a concise, clinically relevant, evidence-based review of the epidemiology, physiology, pathogenesis, diagnosis, and treatment of hypoactive sexual desire disorder (HSDD), a sexual dysfunction affecting approximately 10% of adult women. Etiologic factors include conditions or drugs that decrease brain dopamine, melanocortin, oxytocin, and norepinephrine levels and augment brain serotonin, endocannabinoid, prolactin, and opioid levels...
November 30, 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27916205/efficacy-and-safety-of-transdermal-testosterone-in-postmenopausal-women-with-hypoactive-sexual-desire-disorder-a-systematic-review-and-meta-analysis
#18
Chiara Achilli, Jyotsna Pundir, Parimalam Ramanathan, Luca Sabatini, Haitham Hamoda, Nick Panay
OBJECTIVE: To systematically review and summarize the existing evidence related to the efficacy and safety of transdermal T in postmenopausal women for the treatment of hypoactive sexual desire disorder (HSDD). DESIGN: Systematic reviews and meta-analysis. SETTING: Not applicable. PATIENT(S): Seven randomized controlled trials enrolled 3,035 participants; 1,350 women were randomized to treatment with T patch, and 1,379 women were randomized to placebo...
December 1, 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27915587/the-determination-of-testosterone-esters-and-estradiol-esters-in-bovine-and-porcine-blood-serum
#19
Martina Rejtharová, Libor Rejthar, Katarína Čačková
Monitoring of steroid esters in blood serum is desirable in order to detect possible illegal use of natural hormones as growth promoters. A method for determination of testosterone propionate, testosterone benzoate, testosterone isocaproate, testosterone decanoate and estradiol benzoate in bovine and porcine blood serum was developed. The procedure consists of protein precipitation and removal of phospholipids using a HybridSPE®-Phospholipid column followed by clean-up on a hydrophilic modified styrene polymer Supel(TM) -Select HLB column and LC-MS/MS measurement...
December 5, 2016: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/27915366/aging-has-the-opposite-effect-on-camp-and-cgmp-circadian-variations-in-rat-leydig-cells
#20
Aleksandar Z Baburski, Srdjan J Sokanovic, Silvana A Andric, Tatjana S Kostic
The Leydig cell physiology displays a circadian rhythm driven by a complex interaction of the reproductive axis hormones and circadian system. The final output of this regulatory process is circadian pattern of steroidogenic genes expression and testosterone production. Aging gradually decreases robustness of rhythmic testosterone secretion without change in pattern of LH secretion. Here, we analyzed effect of aging on circadian variation of cAMP and cGMP signaling in Leydig cells. Results showed opposite effect of aging on cAMP and cGMP daily variation...
December 3, 2016: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
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