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https://www.readbyqxmd.com/read/29913543/recommendations-for-the-use-of-testosterone-in-male-transgender
#1
Laura Bregieiro Fernandes Costa, Ana Carolina Japur de Sá Rosa-E-Silva, Sebastião Freitas de Medeiros, Andrea Prestes Nacul, Bruno Ramalho de Carvalho, Cristina Laguna Benetti-Pinto, Daniela Angerame Yela, Gustavo Arantes Rosa Maciel, José Maria Soares Júnior, Técia Maria de Oliveira Maranhão
Gender incongruence is defined as a condition in which an individual self-identifies and desires to have physical characteristics and social roles that connote the opposite biological sex. Gender dysphoria is when an individual displays the anxiety and/or depression disorders that result from the incongruity between the gender identity and the biological sex. The gender affirmation process must be performed by a multidisciplinary team. The main goal of the hormone treatment is to start the development of male physical characteristics by means of testosterone administration that may be offered to transgender men who are 18 years old or over...
May 2018: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/29913170/seasonal-changes-in-plasma-concentrations-of-the-thyroid-glucocorticoid-and-reproductive-hormones-in-the-tegu-lizard-salvator-merianae
#2
Lucas A Zena, Danielle Dillon, Kathleen E Hunt, Carlos A Navas, Kênia C Bícego, C Loren Buck
The tegu lizard Salvator merianae is a large, widely distributed teiid lizard endemic to South America that exhibits annual cycles of high activity during the spring and summer, and hibernation during winter. This pattern of activity and hibernation is accompanied by profound seasonal changes in physiology and behavior, including endothermy during the austral spring. The unusual combination of seasonal endothermy, hibernation and oviparity, in a non-avian, non-mammalian species, makes S. merianae an interesting subject for study of comparative aspects of endocrine regulation of seasonal changes in physiology...
June 15, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29912343/impact-on-testicular-function-of-a-single-ablative-activity-of-3-7-gbq-radioactive-iodine-for-differentiated-thyroid-carcinoma
#3
N Bourcigaux, C Rubino, I Berthaud, M E Toubert, B Donadille, L Leenhardt, I Petrot-Keller, S Brailly-Tabard, J Fromigué, F de Vathaire, T Simon, J P Siffroi, M Schlumberger, P Bouchard, S Christin-Maitre
STUDY QUESTION: What are the consequences of radioactive iodine (RAI) therapy for testicular function? SUMMARY ANSWER: A single activity of 3.7 GBq RAI for differentiated thyroid carcinoma (DTC) treatment in young men transiently altered Sertoli cell function and induced sperm chromosomal abnormalities. WHAT IS KNOWN ALREADY: Few studies, mainly retrospective, have reported the potential impacts of RAI on endocrine and exocrine testicular function...
June 15, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29910424/the-effects-of-a-4-week-intensified-training-and-competition-period-on-salivary-hormones-immunoglobulin-a-illness-symptoms-and-mood-state-in-elite-synchronised-swimmers
#4
Amy Tanner, Shannon Day
Given the limited research into the physiological and psychological demands of elite synchronised swimming, the aim of this study was to examine 10 elite female synchronised swimmers and analyse the relationship between training load, stress, illness episodes, and salivary biomarkers during a period of training and competition. Saliva samples were collected before (BASE), during an intensified training camp (CAMP), during an international competition period (COMP), and post competition recovery (REC) for analysis of cortisol, testosterone, and secretory immunoglobulin A (SIgA)...
September 1, 2017: Sports (Basel)
https://www.readbyqxmd.com/read/29910307/resting-hormone-alterations-and-injuries-block-vs-dup-weight-training-among-d-1-track-and-field-athletes
#5
Keith B Painter, G Gregory Haff, N Travis Triplett, Charles Stuart, Guy Hornsby, Mike W Ramsey, Caleb D Bazyler, Michael H Stone
Daily undulating periodization (DUP), using daily alterations in repetitions, has been advocated as a superior method of resistance training, while traditional forms of programming for periodization (Block) have been questioned. Nineteen Division I track and field athletes were assigned to either a 10-week Block or DUP training group. Year and event were controlled. Over the course of the study, there were four testing sessions, which were used to evaluate a variety of strength characteristics, including maximum isometric strength, rate of force development, and one repetition maximum (1RM)...
January 16, 2018: Sports (Basel)
https://www.readbyqxmd.com/read/29910248/association-of-total-testosterone-free-testosterone-bioavailable-testosterone-and-sex-hormone-binding-globulin-with-hepatic-steatosis-and-the-ratio-of-aspartate-aminotransferase-to-alanine-aminotransferase
#6
Qingtao Yang, Kusheng Wu, Yiyi Zhuang, Haoqiang Wu, Liang Lu, Wencai Li, Zhenjie Li, Xuxia Sui
Several articles have shown the inverse association between total testosterone (TT) or sex hormone-binding globulin (SHBG) and hepatic steatosis. No articles report associations of TT, SHBG, free testosterone (FT), and bioavailable testosterone (BioT) with aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ratios. Therefore, we investigated the associations of TT, FT, BioT and SHBG with hepatic steatosis and AST/ALT ratios. A total of 218 men were enrolled. We diagnosed hepatic steatosis by ultrasound...
June 16, 2018: Endocrine Journal
https://www.readbyqxmd.com/read/29909969/short-term-fasting-reveals-amino-acid-metabolism-as-a-major-sex-discriminating-factor-in-the-liver
#7
Sara Della Torre, Nico Mitro, Clara Meda, Federica Lolli, Silvia Pedretti, Matteo Barcella, Luisa Ottobrini, Daniel Metzger, Donatella Caruso, Adriana Maggi
Sex impacts on liver physiology with severe consequences for energy metabolism and response to xenobiotic, hepatic, and extra-hepatic diseases. The comprehension of the biology subtending sex-related hepatic differences is therefore very relevant in the medical, pharmacological, and dietary perspective. The extensive application of metabolomics paired to transcriptomics here shows that, in the case of short-term fasting, the decision to maintain lipid synthesis using amino acids (aa) as a source of fuel is the key discriminant for the hepatic metabolism of male and female mice...
June 6, 2018: Cell Metabolism
https://www.readbyqxmd.com/read/29909796/impact-of-a-gestational-exposure-to-diesel-exhaust-on-offspring-gonadal-development-experimental-study-in-the-rabbit
#8
M Bourdon, L Torres-Rovira, D Monniaux, C Faure, R Levy, A Tarrade, D Rousseau-Ralliard, P Chavatte-Palmer, G Jolivet
The aim of the present work was to address experimentally the possible impact of exposure to air pollution during gestation on the differentiation and function of the gonads of the offspring using a rabbit model. Rabbits were exposed daily to diluted diesel exhaust gas or filtered air from the 3rd until the 27th day of gestation, during which time germ cells migrate in genital ridges and divide, and fetal sex is determined. Offspring gonads were collected shortly before birth (28th day of gestation) or after puberty (7...
June 18, 2018: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29909545/coalitional-physical-competition-acute-salivary-steroid-hormone-responses-among-juvenile-male-soccer-players-in-hong-kong
#9
Timothy S McHale, Wai-Chi Chee, Ka-Chun Chan, David T Zava, Peter B Gray
A large body of research links testosterone and cortisol to male-male competition. Yet, little work has explored acute steroid hormone responses to coalitional, physical competition during middle childhood. Here, we investigate testosterone, dehydroepiandrosterone (DHEA), androstenedione, and cortisol release among ethnically Chinese boys in Hong Kong (N = 102), aged 8-11 years, during a soccer match (n = 84) and an intrasquad soccer scrimmage (n = 81), with 63 participants competing in both treatments. The soccer match and intrasquad soccer scrimmage represented out-group and in-group treatments, respectively...
June 16, 2018: Human Nature: An Interdisciplinary Biosocial Perspective
https://www.readbyqxmd.com/read/29909262/behavioral-evidence-for-sex-steroids-hypersensitivity-in-castrated-male-canaries
#10
Olesya Shevchouk, Samar Ghorbanpoor, Ed Smith, Philippe Liere, Michael Schumacher, Gregory F Ball, Charlotte A Cornil, Jacques Balthazart
In seasonally breeding songbirds such as canaries, singing behavior is predominantly under the control of testosterone and its metabolites. Short daylenths in the fall that break photorefractoriness are followed by increasing daylengths in spring that activate singing via both photoperiodic and hormonal mechanisms. However, we observed in a group of castrated male Fife fancy canaries maintained for a long duration under a short day photoperiod a large proportion of subjects that sang at high rates. This singing rate was not correlated with variation in the low circulating concentrations of testosterone...
June 14, 2018: Hormones and Behavior
https://www.readbyqxmd.com/read/29908833/direct-actions-of-adiponectin-on-changes-in-reproductive-metabolic-and-anti-oxidative-enzymes-status-in-the-testis-of-adult-mice
#11
Mayank Choubey, Ashutosh Ranjan, Puran S Bora, Fátima Baltazar, Amitabh Krishna
Obesity is a major health problem that is linked to decreased sperm count. It is hypothesized that an obesity-associated reduction in adiponectin secretion may be responsible for impairment of spermatogenesis. Therefore, the aim of the study was to evaluate the direct role of adiponectin in spermatogenesis and steroid synthesis in adult mice. This study showed that adiponectin receptors (AdipoR1 and AdipoR2) were localized in Leydig cells and seminiferous tubules in the testis of adult mice. The result of the in vitro study showed the direct action of adiponectin on spermatogenesis by stimulating cell proliferation (PCNA) and survival (Bcl2) and by suppressing cell apoptosis...
June 14, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29907777/social-status-and-prenatal-testosterone-exposure-assessed-via-second-to-fourth-digit-ratio-affect-6-9-year-old-children-s-prosocial-choices
#12
Lisa Horn, Niklas A Hungerländer, Sonja Windhager, Thomas Bugnyar, Jorg J M Massen
Prosocial behaviour (i.e., voluntary behaviour intended to benefit another) seems to be fully developed in children by the age of 6 years. However, questions about which factors modify prosocial behaviour at that age remain understudied. Here we used a resource allocation paradigm to test prosocial behaviour in 6-9-year-old school children. They could decide between a "selfish" (i.e., one sticker for themselves) and a "prosocial" option (i.e., one sticker for themselves and one for the receiver) and we tested whether friendship, social status and prenatal androgen exposure (approximated by the 2nd to 4th digit ratio; 2D:4D) influenced children's prosocial choices...
June 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29905829/two-hormones-for-one-receptor-evolution-biochemistry-actions-and-pathophysiology-of-lh-and-hcg
#13
Livio Casarini, Daniele Santi, Giulia Brigante, Manuela Simoni
Luteinizing hormone (LH) and chorionic gonadotropin (CG) are glycoproteins fundamental for sexual development and reproduction. Since they act on the same receptor (LHCGR), there is a general consensus that LH and hCG are equivalent. However, separate evolution of LHβ and hCGβ subunits occurred in primates, resulting in two molecules sharing ∼85% identity and regulating different physiological events. Pituitary, pulsatile LH production results in a ∼90 min half-life molecule targeting the gonads, to regulate gametogenesis and androgen synthesis...
June 13, 2018: Endocrine Reviews
https://www.readbyqxmd.com/read/29904126/effect-of-testosterone-treatment-on-bone-remodelling-markers-and-mineral-density-in-obese-dieting-men-in-a-randomized-clinical-trial
#14
Mark Ng Tang Fui, Rudolf Hoermann, Brendan Nolan, Michelle Clarke, Jeffrey D Zajac, Mathis Grossmann
To assess the effect of testosterone treatment on bone remodelling and density in dieting obese men, 100 obese men aged 53 years (interquartile range 47-60) with a total testosterone level <12 nmol/L receiving 10 weeks of a very low energy diet (VLED) followed by 46 weeks of weight maintenance were randomly assigned at baseline to 56 weeks of intramuscular testosterone undecanoate (n = 49, cases) or matching placebo (n = 51, controls). Pre-specified outcomes were between-group differences (mean adjusted difference, MAD) in serum c-telopeptide (CTx), N-terminal propeptide of type 1 procollagen (P1NP) and bone mineral density (BMD)...
June 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29904069/exposure-to-an-anti-androgenic-herbicide-negatively-impacts-reproductive-physiology-and-fertility-in-xenopus-tropicalis
#15
F Orton, M Säfholm, E Jansson, Y Carlsson, A Eriksson, J Fick, T Uren Webster, T McMillan, M Leishman, B Verbruggen, T Economou, C R Tyler, C Berg
Amphibians are threatened on a global scale and pollutants may be contributing to population declines, but how chemicals impact on their reproduction is poorly understood. We conducted a life cycle analysis to investigate the impacts of early life exposure to two anti-androgens (exposure until completion of metamorphosis;stage 66): flutamide, (50 µg/L)/linuron (9 and 45 µg/L)) on sexual development and breeding competence in Xenopus tropicalis. Our analyses included: mRNA levels of dmrt1, cyp17, amh, cyp19, foxl2 and ar (tadpoles/metamorphs), gonadal histomorphology (metamorphs/adults), mRNA levels of ar/gr (adult male brain/gonad/forelimb), testosterone/corticosterone levels (adult males), secondary sexual characteristics (forelimb width/nuptial pad: adult males) and breeding competence (amplexus/fertility: adult males)...
June 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29903778/clitoromegaly-beyond-testosterone
#16
Darshana Sudip Thakur, Chaitanya G Yerawar, Meghana Phiske, Nikhil M Bhagwat
No abstract text is available yet for this article.
June 14, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29903608/management-of-pediatric-patients-with-dsd-and-ambiguous-genitalia-balancing-the-child-s-moral-claims-to-self-determination-with-parental-values-and-preferences
#17
David A Diamond, Jonathan Swartz, Amy Tishelman, Judith Johnson, Yee-Ming Chan
INTRODUCTION: A central ethical dilemma in management of the patient with a disorder of sex development (DSD) is the potential conflict between respect for the fundamental right of the child for physical and emotional integrity and self-determination, and the right of parents to serve as surrogate decision-makers and act in their child's best interest. METHODS: Over the past 2 years we have encountered three complex DSD cases on the spectrum of mixed gonadal dysgenesis to ovotesticular DSD in which gender assignment and therefore optimal surgical management was uncertain...
June 1, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29902666/effects-of-testosterone-administration-on-threat-and-escape-anticipation-in-the-orbitofrontal-cortex
#18
Sarah J Heany, Richard A I Bethlehem, Jack van Honk, Peter A Bos, Dan J Stein, David Terburg
Recent evidence suggests that the steroid hormone testosterone can decrease the functional coupling between orbitofrontal cortex (OFC) and amygdala. Theoretically this decoupling has been linked to a testosterone-driven increase of goal-directed behaviour in case of threat, but this has never been studied directly. Therefore, we placed twenty-two women in dynamically changing situations of escapable and inescapable threat after a within-subject placebo controlled testosterone administration. Using functional magnetic resonance imaging (fMRI) we provide evidence that testosterone activates the left lateral OFC (LOFC) in preparation of active goal-directed escape and decouples this OFC area from a subcortical threat system including the central-medial amygdala, hypothalamus and periaqueductal gray...
May 30, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29902490/decreased-h3k9ac-level-of-star-mediated-testicular-dysplasia-induced-by-prenatal-dexamethasone-exposure-in-male-offspring-rats
#19
Min Liu, Biao Chen, Linguo Pei, Qi Zhang, Yunfei Zou, Hao Xiao, Jin Zhou, Liaobin Chen, Hui Wang
Prenatal dexamethasone exposure (PDE) could induce testicular developmental toxicity in adults. The present study aims to confirm its intrauterine origination, and to explore its potential intrauterine programming mechanism. The pregnant rats were respectively injected subcutaneously with 0.2 and 0.8 mg/kg⋅d dexamethasone during gestational days (GD) 9 to 20. The testes and serum of offspring rats were collected on GD20 and postnatal week (PW) 12. In vivo, PDE significantly induced the abnormal testicular morphology in offspring from GD20 to PW12...
June 11, 2018: Toxicology
https://www.readbyqxmd.com/read/29902186/no-relationship-between-autistic-traits-and-salivary-testosterone-concentrations-in-men-from-the-general-population
#20
Diana Weiting Tan, Murray T Maybery, Michael W Clarke, Renata Di Lorenzo, Melissa O Evans, Michael Mancinone, Christina Panos, Andrew J O Whitehouse
It is suggested that testosterone may play a part in the higher prevalence of Autism Spectrum Disorder (ASD) in males compared to females. Previous studies have reported elevated postnatal testosterone levels in children and women with ASD but not in men. We compared levels of salivary testosterone across 67 undergraduate males (Mage 19.5 yrs, SD 1.92) selected for low, mid-range and high levels of autistic traits assessed using the Autism-spectrum Quotient. Analyses revealed no significant differences in testosterone concentrations across the three groups...
2018: PloS One
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