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https://www.readbyqxmd.com/read/29474646/serum-levels-of-testosterone-and-shbg-in-association-with-body-mass-index-improve-the-predictive-capability-of-consolidate-tumor-biomarkers-in-pre-and-postmenopausal-breast-cancer-patients
#1
Danila Coradini, Annalisa Orenti, Elisabetta Venturelli, Adalberto Cavalleri, Elia Biganzoli, Saro Oriana
Objective: To investigate the contribution of serum levels of testosterone (TS) and sex hormone binding globulin (SHBG) in association with body mass index (BMI) as a surrogate marker of obesity, to the predictive capability of tumor size (T), lymph node (N) and estrogen receptor (ER) status and proliferative activity (TLI). Methods: We investigated 120 women with primary breast cancer and median follow-up of 138 months. Serum levels of TS and SHBG and patient's BMI were evaluated before surgery...
February 21, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29473384/five-year-prospective-study-on-cardiovascular-events-in-patients-with-erectile-dysfunction-and-hypotestosterone
#2
Rosanna Iacona, Vito Bonomo, Mariaconcetta Di Piazza, Angela Sansone, Manuela Usala, Salvatore Novo, Carlo Pavone
OBJECTIVE: Testosterone levels play a role in cardiac and vascular pathology. In the present study we investigated the prognostic significance of this hormone for cardiovascular outcome, in a 5-year follow-up. MATERIALS AND METHODS: Our cohort included 802 adult subjects, from 40 to 80 years. Patients were excluded if they had a past history of peripheral or coronary artery disease, and revascularization. A blood sample was drawn to valuate testosterone level, and we considered normal testosterone levels 300 ng/dl...
December 31, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/29473373/medical-management-in-locally-advanced-and-metastatic-prostate-cancer-does-changes-in-treatment-policy-have-any-specific-effect-on-psa-levels
#3
Murat Bagcioglu, Cristian Surcel, Serkan Ozcan, Cristian Mirvald, Mehmet Ali Karagoz, Mert Ali Karadag, Emre Huri, Kemal Sarica
OBJECTIVE: Androgen deprivation therapy (ADT) is commonly used as a first-line treatment for locally advanced and metastatic prostatic cancer (Pca). There is no consensus about which alternative treatment should be used after the failure of initial ADT. We aimed to investigate the effect of changes in treatment on PSA and testosterone levels. MATERIAL AND METHODS: A total of 120 patients with an established diagnosis of either locally advanced or metastatic Pca in two different centers...
December 31, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/29472740/physiological-and-performance-changes-in-national-and-international-judo-athletes-during-block-periodization-training
#4
Lucas Marques, Emerson Franchini, Gustavo Drago, Marcelo S Aoki, Alexandre Moreira
Block periodization (BP) has been proposed as an alternative approach for application in the context of high-level sports. Despite its growing acceptance, there is no empirical evidence of BP adoption in high-level judo athletes. Therefore, this study aimed to compare the maximal strength, muscle power, judo-specific performances, and hormonal concentration changes of state/national level (NG) and international level (IG) judo athletes subjected to BP. Twenty-one elite judo athletes (international level = 10; 21...
December 2017: Biology of Sport
https://www.readbyqxmd.com/read/29472732/is-the-technical-performance-of-young-soccer-players-influenced-by-hormonal-status-sexual-maturity-anthropometric-profile-and-physical-performance
#5
Alexandre Moreira, Marcelo Massa, Carlos R Thiengo, Rafael Alan Rodrigues Lopes, Marcelo R Lima, Roel Vaeyens, Wesley P Barbosa, Marcelo S Aoki
The aim of this study was to examine the influence of hormonal status, anthropometric profile, sexual maturity level, and physical performance on the technical abilities of 40 young male soccer players during small-sided games (SSGs). Anthropometric profiling, saliva sampling, sexual maturity assessment (Tanner scale), and physical performance tests (Yo-Yo and vertical jumps) were conducted two weeks prior to the SSGs. Salivary testosterone was determined by the enzyme-linked immunosorbent assay method. Technical performance was determined by the frequency of actions during SSGs...
December 2017: Biology of Sport
https://www.readbyqxmd.com/read/29471520/effect-of-exposure-to-second-hand-smoke-from-husbands-on-biochemical-hyperandrogenism-metabolic-syndrome-and-conception-rates-in-women-with-polycystic-ovary-syndrome-undergoing-ovulation-induction
#6
Jian Li, Q Wu, Xiao-Ke Wu, Zhong-Ming Zhou, Ping Fu, Xiu-Hua Chen, Ying Yan, Xin Wang, Zheng-Wang Yang, Wei-Li Li, Elisabet Stener-Victorin, Richard S Legro, Ernest Hung-Yu Ng, Heping Zhang, Ben Willem J Mol, Chi Chiu Wang
STUDY QUESTION: Does second-hand smoke (SHS) exposure from husbands have adverse effects on sex hormones, metabolic profiles, clinical phenotypes and fertility outcomes in women with polycystic ovary syndrome (PCOS) undergoing ovulation induction? SUMMARY ANSWER: SHS exposure is associated with worsened biochemical hyperandrogenism, higher incidence of metabolic syndrome and reduced conception rates in women with PCOS. WHAT IS KNOWN ALREADY: Smoking in women impairs fecundity at some stages of the reproductive process including folliculogenesis, embryo transport, endometrial angiogenesis and uterine blood flow...
February 20, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29471444/relation-of-sex-hormone-levels-with-prevalent-and-10-year-change-in-aortic-distensibility-assessed-by-mri-the-multi-ethnic-study-of-atherosclerosis
#7
V Subramanya, B Ambale-Venkatesh, Y Ohyama, D Zhao, C C Nwabuo, W S Post, E Guallar, P Ouyang, S J Shah, M A Allison, C E Ndumele, D Vaidya, D A Bluemke, J A Lima, E D Michos
Background: Women experience a steeper decline in aortic elasticity related to aging compared to men. We examined whether sex hormone levels were associated with ascending aortic distensibility (AAD) in the Multi-Ethnic Study of Atherosclerosis. Methods: We studied 1,345 post-menopausal women and 1,532 men aged 45-84 years, who had serum sex hormone levels, AAD measured by phase-contrast cardiac magnetic resonance imaging, and ejection fraction>50% at baseline...
February 19, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29471436/antiandrogen-treatment-ameliorates-reproductive-and-metabolic-phenotypes-in-the-letrozole-induced-mouse-model-of-pcos
#8
Genevieve E Ryan, Shaddy Malik, Pamela L Mellon
Polycystic ovary syndrome (PCOS), the most common endocrinopathy in women of reproductive age, is characterized by hyperandrogenism, anovulation, and polycystic ovaries. Although its etiology is unknown, excess androgens are thought to be a critical factor driving the pathology of PCOS. We previously demonstrated that continuous exposure to the aromatase inhibitor letrozole (LET) in mice produces many hallmarks of PCOS, including elevated testosterone (T) and luteinizing hormone (LH), anovulation, and obesity...
February 19, 2018: Endocrinology
https://www.readbyqxmd.com/read/29471403/influence-of-distiller-s-dried-grains-with-solubles-on-ram-lamb-growth-and-reproductive-traits
#9
A R Crane, R R Redden, M S Crouse, J D Kirsch, P P Borowicz, J E Held, K C Swanson, C S Schauer
The hypothesis of this experiment was that increasing the inclusion level of distiller's dried grains (DDGS) in the diets would decrease semen quality but have no negative effects on growth performance. Following the removal of DDGS from the diet, it was hypothesized that the ram lambs would recover and become reproductively sound, independent of treatment. To test this hypothesis, Suffolk and Hampshire ram lambs (n = 112) were allocated to four treatments (n = 4 pens/treatment; 7 rams/pen) in a completely randomized design...
February 20, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29470364/resistance-training-is-associated-with-higher-bone-mineral-density-among-young-adult-male-distance-runners-independent-of-physiological-factors
#10
Anthony A Duplanty, Danielle E Levitt, David W Hill, Brian K McFarlin, Nancy M DiMarco, Jakob L Vingren
Low bone mineral density (BMD) in male distance runners is common and could be modulated by a host of biomarkers involved in the dynamic balance of bone tissue. In contrast, resistance training can increase BMD; however, the efficacy of resistance training in protecting BMD in distance runners has not been elucidated. OBJECTIVE: To investigate the relationship between resistance training, testosterone and bone metabolism biomarker concentrations, and BMD in young adult male distance runners...
February 20, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29469650/prenatal-androgen-exposure-causes-hypertension-and-gut-microbiota-dysbiosis
#11
Shermel Sherman, Nadeen Sarsour, Marziyeh Salehi, Allen Schroering, Blair Mell, Bina Joe, Jennifer W Hill
BACKGROUND: Conditions of excess androgen in women, such as polycystic ovary syndrome (PCOS), often exhibit intergenerational transmission. One way in which the risk for PCOS may be increased in daughters of affected women is through exposure to elevated androgens in utero. Hyperandrogenemic conditions have serious health consequences, including increased risk for hypertension and cardiovascular disease. Recently, gut dysbiosis has been found to induce hypertension in rats, such that blood pressure can be normalized through fecal microbial transplant...
February 22, 2018: Gut Microbes
https://www.readbyqxmd.com/read/29468986/increased-endothelial-dysfunction-and-insulin-resistance-in-patients-with-klinefelter-syndrome
#12
Cem Haymana, Aydogan Aydogdu, Ibrahim Demirci, Mustafa Dinc, Orhan Demir, Deniz Torun, Fatih Yesildal, Coskun Meric, Yalcın Basaran, Alper Sonmez, Omer Azal
Patients with Klinefelter Syndrome (KS) have increased cardiometabolic risk however the pathogenesis is not clear. We investigated the presence of endothelial dysfunction, insulin resistance and inflammation in an unconfounded population of KS. A total of 32 patients with KS (mean age 21.59 ± 1.66 years) and 33 healthy control subjects (mean age: 22.15 ± 1.03 years) were enrolled. The demographic parameters, Asymmetric dimethylarginine (ADMA), homeostatic model assessment of insulin resistance (HOMA-IR) index and high-sensitivity C-reactive protein (hs-CRP) levels were measured...
February 19, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29468912/hormone-treatments-in-congestive-heart-failure
#13
Lei Lei, Yuanjie Mao
The common ultimate pathological feature for all cardiovascular diseases, congestive heart failure (CHF), is now considered as one of the main public health burdens that is associated with grave implications. Neurohormonal systems play a critical role in cardiovascular homeostasis, pathophysiology, and cardiovascular diseases. Hormone treatments such as the newly invented dual-acting drug valsartan/sacubitril are promising candidates for CHF, in addition to the conventional medications encompassing beta receptor blockers, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, and mineralocorticoid receptor antagonists...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29468906/quantification-of-10-steroid-hormones-in-human-saliva-from-chinese-adult-volunteers
#14
Jian Liu, Xuemei Qiu, Daoming Wang, Yantao Li, Yang Zong, Yichen Liu, Yue Zhang, Ping Yang, Yong Zuo, Huanming Yang, Jian Wang, Yutao Du, Jin Zi
Objective This study was performed to investigate the effects of age and sex on 10 salivary steroid hormones and analyze the correlations between salivary and plasma hormones. Methods The concentrations of 10 salivary steroid hormones in 1090 Chinese adult volunteers were examined using liquid chromatography-tandem mass spectrometry, and a related investigation was performed on the concentrations of salivary hormones in this population. Results The concentrations of androstenedione (A4), 17α-hydroxyprogesterone (17-OHP), aldosterone (ALD), cortisone (COR), corticosterone (CORT), cortisol (F), progesterone (P), and testosterone were significantly different between men and women (Student's t-test)...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29468843/gpcr6a-is-a-molecular-target-for-the-natural-products-gallate-and-egcg-in-green-tea
#15
Min Pi, Karan Kapoor, Ruisong Ye, Jeremy C Smith, Jerome Baudry, L Darryl Quarles
SCOPE: The molecular mechanisms whereby gallates in green tea exert metabolic effects are poorly understood. METHODS AND RESULTS: We found that GPRC6A, a multi-ligand sensing G-protein coupled receptor that regulates energy metabolism, sex hormone production and prostate cancer progression, is a target for gallates. Sodium gallate,1 gallic acid (GA) > ethyl gallate (EG) > octyl gallate (OG) dose dependently activated ERK in HEK-293 cells transfected with GPRC6A but not in non-transfected controls...
February 21, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29468748/the-effect-of-dietary-soy-intake-on-weight-loss-glycaemic-control-lipid-profiles-and-biomarkers-of-inflammation-and-oxidative-stress-in-women-with-polycystic-ovary-syndrome-a-randomised-clinical-trial
#16
M Karamali, M Kashanian, S Alaeinasab, Z Asemi
BACKGROUND: The present study aimed to evaluate the effects of dietary soy intake on weight loss and metabolic status of patients with polycystic ovary syndrome (PCOS). METHODS: A randomised clinical trial was conducted among 60 women with PCOS. Participants were randomly assigned into two groups to receive either a test diet (n = 30) or a control diet (n = 30) for 8 weeks. Participants in the test group consumed a diet containing 0.8 g protein kg-1 body weight (35% animal proteins, 35% soy protein and 30% vegetable proteins) and participants in the control group consumed a similar diet containing 70% animal proteins and 30% vegetable proteins...
February 22, 2018: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://www.readbyqxmd.com/read/29468717/brysocarpus-coccineus-schum-thonn-root-reinstates-sexual-competence-and-testicular-function-in-paroxetine-induced-sexual-dysfunction-in-male-wistar-rats
#17
M T Yakubu, A R Atoyebi
The effects of aqueous extract of Brysocarpus coccineus roots (AEBCR) were studied on sexual behaviour and testicular function of paroxetine-induced sexual dysfunction (SD) in male rats. Ninety, sexually matured male rats (150.88 ± 5.53 g) were assigned into two groups: A and B. Fifteen SD animals from group B were each allotted to B1, B2, B3, B4 and B5 and received distilled water (DW), Powmax M (7.14 mg/kg body weight, b.w.) 50, 100 and 150 mg/kg b.w of AEBCR, respectively, for 7 days while the non-SD animals (group A) received DW...
February 22, 2018: Andrologia
https://www.readbyqxmd.com/read/29468688/polymorphisms-of-cytochrome-p450-2b6-cyp2b6-in-cynomolgus-and-rhesus-macaques
#18
Yasuhiro Uno, Shotaro Uehara, Hiroshi Yamazaki
BACKGROUND: Cytochrome P450 2B6 (CYP2B6) is an important drug-metabolizing enzyme and is expressed in liver. Although human CYP2B6 variants account for variable enzyme properties among individuals and populations, CYP2B6 genetic variants have not been investigated in cynomolgus macaques, widely used in drug metabolism studies. METHODS: CYP2B6 was resequenced in 120 cynomolgus macaques and 23 rhesus macaques by direct sequencing. RESULTS: Twenty-three non-synonymous variants were found, of which 12 and 3 were unique to cynomolgus macaques and rhesus macaques, respectively...
February 22, 2018: Journal of Medical Primatology
https://www.readbyqxmd.com/read/29468520/impact-of-di-2-ethylhexyl-phthalate-metabolites-on-male-reproductive-function-a-systematic-review-of-human-evidence
#19
REVIEW
Birgit Bjerre Høyer, Virissa Lenters, Aleksander Giwercman, Bo A G Jönsson, Gunnar Toft, Karin S Hougaard, Jens Peter E Bonde, Ina Olmer Specht
PURPOSE OF REVIEW: The purpose of this review is to systematically review the literature linking di-2-ethylhexyl phthalate (DEHP) exposure with effects on reproductive health in adult males. RECENT FINDINGS: Thirty-three papers were included of which 28 were cross-sectional. Twenty-one papers investigated semen samples, 18 investigated reproductive hormones, and three studies investigated time to pregnancy. Studies revealed some but inconsistent indications that higher urinary DEHP metabolite levels are associated with an increase in the proportion of spermatozoa with damaged DNA and to a decrease in sperm concentration and motility...
February 21, 2018: Current Environmental Health Reports
https://www.readbyqxmd.com/read/29467992/obesity-an-enemy-of-male-fertility-a-mini-review
#20
REVIEW
Mohamed Ahmed Abd El Salam
Obesity is a highly prevalent non-communicable disease worldwide and is commonly associated with male infertility. Several etiopathological theories have been mentioned in the literature by which obesity affects spermatogenesis, thus affecting the male fertility potential. Mechanisms for explaining the effect of obesity on male infertility include endocrinopathy, increased aromatization activity, associated erectile dysfunction, psychological and thermal effects, obstructive sleep apnea, increased leptin and oxygen free radicals, and associated inflammatory and obstructive elements of epididymitis...
January 2018: Oman Medical Journal
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