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https://www.readbyqxmd.com/read/28430630/estrogen-and-androgen-converting-enzymes-17%C3%AE-hydroxysteroid-dehydrogenase-and-their-involvement-in-cancer-with-a-special-focus-on-17%C3%AE-hydroxysteroid-dehydrogenase-type-1-2-and-breast-cancer
#1
REVIEW
Erik Hilborn, Olle Stål, Agneta Jansson
Sex steroid hormones such as estrogens and androgens are involved in the development and differentiation of the breast tissue. The activity and concentration of sex steroids is determined by the availability from the circulation, and on local conversion. This conversion is primarily mediated by aromatase, steroid sulfatase, and 17β-hydroxysteroid dehydrogenases. In postmenopausal women, this is the primary source of estrogens in the breast. Up to 70-80% of all breast cancers express the estrogen receptor-α, responsible for promoting the growth of the tissue...
February 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28429281/impact-of-thyroid-disease-on-testicular-function
#2
REVIEW
Sandro La Vignera, Roberto Vita, Rosita A Condorelli, Laura M Mongioì, Silvia Presti, Salvatore Benvenga, Aldo E Calogero
INTRODUCTION: Testis was considered unresponsive to thyroid hormone for a long time. However, like in animals, the presence of thyroid hormone receptors in different testicular cell types was demonstrated also in humans. Accordingly, thyrotoxicosis and hypothyroidism have remarkable effects on testicular function and more extensively on fertility. REVIEW: Thyrotoxicosis and hypothyroidism are associated with changes affecting the endocrine, sexual, or reproductive functions...
April 20, 2017: Endocrine
https://www.readbyqxmd.com/read/28429139/rates-of-parasitism-but-not-allocation-of-egg-resources-vary-among-and-within-hosts-of-a-generalist-avian-brood-parasite
#3
Loren Merrill, Scott J Chiavacci, Ryan T Paitz, Thomas J Benson
Brown-headed cowbirds (Molothrus ater) deposit their eggs into the nests of other birds, which then raise the cowbird chick. Female cowbirds thus have limited options for impacting their offspring's development via maternal effects compared to most other passerines. Cowbirds can impact their offspring's phenotype by choosing among potential host nests, and by adjusting egg resources based on host characteristics. To examine whether cowbirds exhibit either or both of these strategies, we investigated rates of cowbird parasitism and egg investment (egg size, yolk-to-albumen ratio, and yolk testosterone and androstenedione) among and within host species in a shrubland bird community...
April 20, 2017: Oecologia
https://www.readbyqxmd.com/read/28428942/follicular-fluid-cerebellin-and-betatrophin-regulate-the-metabolic-functions-of-growing-follicles-in-polycystic-ovary-syndrome
#4
Aynur Adeviye Ersahin, Mustafa Acet, Suat Suphan Ersahin, Tuba Acet, Meltem Yardim, Omer Kenanoglu, Suleyman Aydin
OBJECTIVE: The aim of this study was to assess the changes of follicular fluid (FF) and serum levels of cerebellin precursor protein 1 (cbln1) and betatrophin in patients with polycystic ovary syndrome (PCOS) undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) with a gonadotropin-releasing hormone (GnRH) antagonist protocol. METHODS: Twenty infertile women with PCOS and 20 control women diagnosed as poor responders undergoing ovarian stimulation with a GnRH antagonist were included...
March 2017: Clinical and Experimental Reproductive Medicine
https://www.readbyqxmd.com/read/28428002/performance-during-competition-and-competition-outcome-in-relation-to-testosterone-and-cortisol-among-women
#5
Andrea Henry, Jason R Sattizahn, Greg J Norman, Sian L Beilock, Dario Maestripieri
A contribution to a special issue on Hormones and Human Competition. This study investigated the relation between competition, testosterone (T), and cortisol (C) in women. One hundred and twenty female participants competed against a male confederate in a computerized laboratory task. The task was preprogrammed so that half the women won and half of the women lost the competition. T and C concentrations were measured in saliva samples collected at four time points before and after the competition. Accuracy and reaction time during the competition were recorded...
April 17, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28426948/digit-ratio-2d-4d-and-handgrip-strength-are-correlated-in-women-but-not-in-men-in-hui-ethnicity
#6
Hong Lu, Dan Shen, Lu Wang, Shibo Niu, Chunyue Bai, Zhanbing Ma, Zhenghao Huo
INTRODUCTION: Digit ratio, especially second-to-fourth digit ratio (2D:4D) is used as a biomarker of prenatal testosterone exposure and was found associated with physical ability, such as handgrip strength (HGS). Recently, this association has been discussed in several ethnic groups. AIMS: To investigate correlations between 2D:4D and HGS in Chinese population of Ningxia Hui ethnicity. METHODS: Here we firstly present the evidence on digit ratio and HGS of 346 college students (119 males and 227 females) by collecting photographs and HGS of both hands at Yinchuan city, in the Ningxia province of China...
April 17, 2017: Early Human Development
https://www.readbyqxmd.com/read/28426945/testosterone-levels-in-healthy-men-correlate-negatively-with-serotonin-4-receptor-binding
#7
Erik Perfalk, Sofi da Cunha-Bang, Klaus K Holst, Sune Keller, Claus Svarer, Gitte M Knudsen, Vibe G Frokjaer
The serotonergic system integrates sex steroid information and plays a central role in mood and stress regulation, cognition, appetite and sleep. This interplay may be critical for likelihood of developing depressive episodes, at least in a subgroup of sensitive individuals. The serotonin 4 receptor (5-HT4R) indexes central serotonergic tonus, which may be related to endogenous sex-steroid levels in the mentally healthy state even though this remains elusive. Here we evaluate if peripheral levels of estradiol and testosterone are associated with 5-HT4R binding as imaged by [(11)C]SB207145 positron emission tomography in a group of 41 healthy men...
March 22, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28425408/testosterone-sex-hormone-binding-globulin-and-nonalcoholic-fatty-liver-disease-a-systematic-review-and-meta-analysis
#8
Veeravich Jaruvongvanich, Anawin Sanguankeo, Tanawan Riangwiwat, Sikarin Upala
INTRODUCTION AND AIM: Endogenous sex hormones are associated with the risk of diabetes and metabolic syndrome. Recent studies suggested the role of these hormones in nonalcoholic fatty liver disease (NAFLD). We conducted a systematic review and meta-analysis of observational studies investigating the association between sex hormones and NAFLD. MATERIAL AND METHODS: A comprehensive search of the databases of the MEDLINE and EMBASE was performed from inception through April 2016...
May 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28425104/inactivation-kinetics-and-residual-activity-of-cyp3a4-after-treatment-with-erythromycin
#9
Yuko Ishikawa, Takeshi Akiyoshi, Ayuko Imaoka, Hisakazu Ohtani
This study aimed to characterize the inactivation kinetics of cytochrome P450 3A4 (CYP3A4) by erythromycin, which involves mechanism-based inhibition (MBI), in detail. In addition to an MBI assay based on the conventional method in which erythromycin and recombinant CYP3A4 were pre-incubated for 15 min, we also evaluated the long-term MBI kinetics of this reaction by pre-incubating for 120 min. MBI profiles were obtained using three typical substrates, testosterone, midazolam, and nifedipine. In the long-term assay, erythromycin evoked a time-dependent biphasic reduction in enzyme activity, but some residual activity (α) was detected in the terminal phase...
April 20, 2017: Biopharmaceutics & Drug Disposition
https://www.readbyqxmd.com/read/28424957/assessing-pahs-pollution-in-shandong-coastal-area-china-by-combination-of-chemical-analysis-and-responses-of-reproductive-toxicity-in-crab-portunus-trituberculatus
#10
Luqing Pan, Ruiyi Xu, Jianmin Wen, Ruiming Guo
The concentrations of PAHs in seawater and sediments were measured at three selected sites (S1, S2, and S3) along the coastal area of Shandong (China) in April, May, and June, 2015, which ranged from 29.72 to 123.88 ng/L and 82.62 to 232.63 ng/g, respectively. Meanwhile, the reproductive toxicity responses in crab Portunus trituberculatus were also evaluated to assess the pollution of PAHs during the sampling period. Chemical analysis showed that S3 was the most PAH-contaminated area while S1 was the least, and the biochemical parameters concerned with reproduction were efficiently responded to the three sites, especially in S3 (p < 0...
April 19, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28424894/the-integrity-of-the-nucleus-of-the-lateral-olfactory-tract-is-essential-for-the-normal-functioning-of-the-olfactory-system
#11
Ricardo P Vaz, Armando Cardoso, Susana I Sá, Pedro A Pereira, M Dulce Madeira
The nucleus of the lateral olfactory tract (nLOT) is a relatively small component of the cortical pallial amygdala, with peculiar neurogenic, neurochemical and connectivity patterns. Although it has been suggested that it might be involved in non-pheromonal olfactory-guided behaviors, particularly feeding, the functional implications of the nLOT have never been investigated. In view of this fact, we have tackled this subject by performing a series of behavioral tests and by quantifying biological and biochemical parameters in sexually naïve adult male rats that were submitted to bilateral excitotoxic lesions of the nLOT...
April 19, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28424505/usefulness-of-serum-fetuin-a-level-as-a-marker-of-erectile-dysfunction
#12
W Kandeel, W El-Shaer, A Sebaey, A A Abou-Taleb, A Fathy, B Elmohamady, A I Mansour
This study aimed to evaluate the correlation between serum levels of fetuin-A and the presence and severity of erectile dysfunction (ED) in Egyptian population. The study was performed on 60 ED patients and 20 age-matched healthy controls. A comprehensive medical history and complete physical examination were obtained and performed in all participants. ED and its severity were assessed via International Index of Erectile Function (IIEF-5). Doppler ultrasound, fasting blood glucose level, complete lipid profile, serum total testosterone (TT) and serum fetuin-A were performed...
April 20, 2017: International Journal of Impotence Research
https://www.readbyqxmd.com/read/28424502/significance-of-serum-endothelial-cell-specific-molecule-1-endocan-level-in-patients-with-erectile-dysfunction-a-pilot-study
#13
M Karabakan, A Bozkurt, S Akdemir, M Gunay, E Keskin
This study aimed to measure the serum endocan level of patients with erectile dysfunction (ED) and to investigate the possible association between the Endothelial-specific molecule-1 (Endocan) level and ED. Twenty healthy and sixty-four male patients included in the study were divided into four groups: severe ED (19 patients), moderate ED (24 patients), mild ED (21 patients) and control group (20 healthy men). The erectile function of all the patients was evaluated using the International Index of Erectile Function-5 (IIEF-5) questionnaire...
April 20, 2017: International Journal of Impotence Research
https://www.readbyqxmd.com/read/28423972/sexual-function-and-testosterone-level-in-men-with-conservatively-treated-chronic-kidney-disease
#14
Kerstin S Fugl-Meyer, Marie Nilsson, Britta Hylander, Mikael Lehtihet
Sexual dysfunctions are common, but underrecognized, in patients with chronic kidney disease (CKD) and are inversely associated with the glomerular filtration rate (GFR). Sexual dysfunctions may affect quality of life in males with CKD. The aim of this study was to analyze the relationship among sex hormones, sexual function, and sexual satisfaction in a group of men between 18 and 50 years of age with CKD Stages 1 to 5 not treated with hemodialysis or peritoneal dialysis. Fasting blood samples for hemoglobin, testosterone, prolactin, and luteinizing hormone and questionnaire surveys (Sexual Complaints Screener for Men, International Index of Erectile Function, and Aging Male Symptom scale) were evaluated in 100consecutive men...
April 1, 2017: American Journal of Men's Health
https://www.readbyqxmd.com/read/28423563/regulation-of-p53wt-glioma-cell-proliferation-by-androgen-receptor-mediated-inhibition-of-small-vcp-p97-interacting-protein-expression
#15
Dejun Bao, Chuandong Cheng, Xiaoqiang Lan, Rong Xing, Zhuo Chen, Hua Zhao, Junyan Sun, Yang Wang, Chaoshi Niu, Bo Zhang, Shengyun Fang
The incidence of glioma in men is higher than that in women; however, little is known about the expression and basic function of the androgen receptor (AR) in gliomas. AR inhibited the small VCP/p97-interacting protein (SVIP) on the transcriptional level was previously reported. The present study shows that the protein level of AR is highly expressed in cell lines of the nervous system. Moreover, the AR expression is increased while SVIP expression is decreased in tumor tissue of glioma patients, which is in agreement with the progressing WHO grades...
April 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28423207/nano-lc-ms-ms-analysis-of-steroids-from-gray-whale-blubber
#16
Mary Hayden, Ruchika Bhawal, John Escobedo, Clinton Harmon, Todd O'Hara, David Klein, Susan San-Francisco, Masoud Zabet-Moghaddam, Céline A J Godard-Codding
RATIONALE: Analysis of steroids from precious blubber biopsies obtained from marine mammals, especially endangered species, can provide valuable information on their endocrine status. Challenges with currently used ELISA methodology include lack of absolute quantitation and incompatibility with multiple steroids analysis due to limited biopsy mass. Development of a sensitive, accurate analytical method for this purpose is critical. METHODS: A nanoLC/MS/MS method was validated for sensitive, specific and quantitative analysis of three steroid hormones, without derivatization, extracted from 50 mg blubber samples...
April 19, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28422530/physiological-changes-following-competition-in-male-and-female-physique-athletes-a-pilot-study
#17
Eric T Trexler, Katie R Hirsch, Bill I Campbell, Abbie E Smith-Ryan
The purpose of the current study was to evaluate changes in body composition, metabolic rate, and hormones during post-competition recovery. Data were collected from natural physique athletes (7 male/8 female) within one week before (T1) competition, within one week after (T2), and 4-6 weeks after (T3) competition. Measures included body composition (fat mass [FM] and lean mass [LM] from ultrasongraphy), resting metabolic rate (RMR; indirect calorimetry), and salivary leptin, testosterone, cortisol, ghrelin, and insulin...
April 19, 2017: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/28421834/long-term-testosterone-therapy-improves-cardiometabolic-function-and-reduces-risk-of-cardiovascular-disease-in-men-with-hypogonadism
#18
Abdulmaged M Traish, Ahmad Haider, Karim Sultan Haider, Gheorghe Doros, Farid Saad
OBJECTIVES: In the absence of large, prospective, placebo-controlled studies of longer duration, substantial evidence regarding the safety and risk of testosterone (T) therapy (TTh) with regard to cardiovascular (CV) outcomes can only be gleaned from observational studies. To date, there are limited studies comparing the effects of long-term TTh in men with hypogonadism who were treated or remained untreated with T, for obvious reasons. We have established a registry to assess the long-term effectiveness and safety of T in men in a urological setting...
January 1, 2017: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28421826/6-gingerol-improves-testicular-function-in-mice-model-of-chronic-ulcerative-colitis
#19
E O Farombi, I A Adedara, B O Ajayi, T E Idowu, O O Eriomala, F O Akinbote
The persistent inflammation and oxidative stress at the local site in ulcerative colitis reportedly extend to the testes via systemic circulation resulting in testicular dysfunction. The influence of 6-gingerol (6G), a phenolic compound isolated from Zingiber officinale, on colitis-mediated testicular dysfunction in mice was investigated in this study. Chronic ulcerative colitis was induced in mice using 2.5% dextran sulfate sodium (DSS) in drinking water for three cycles. Each cycle consisted of 7 consecutive days of exposure to DSS-treated water followed by 14 consecutive days of normal drinking water...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/28420996/chronic-water-pipe-smoke-exposure-induces-injurious-effects-to-reproductive-system-in-male-mice
#20
Badreldin H Ali, Khalid A Al Balushi, Mohammed Ashique, Asem Shalaby, Mohammed A Al Kindi, Sirin A Adham, Turan Karaca, Sumaya Beegam, Priya Yuvaraju, Abderrahim Nemmar
There is a global increase in the popularity of water-pipe tobacco smoking including in Europe and North America. Nevertheless, little is known about the male reproductive effects of water-pipe smoke (WPS), especially after long-term exposure. Here, we assessed effects of WPS exposure (30 min/day) in male mice for 6 months. Control mice were exposed to air-only for the same period of time. Twenty-four hours after the last exposure, testicular histopathology, and markers of inflammation and oxidative stress, and the tyrosine-protein kinase vascular endothelial growth factor receptor 1 (VEGFR1) were assessed in testicular homogenates...
2017: Frontiers in Physiology
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