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https://www.readbyqxmd.com/read/26907523/introduction-of-new-formulas-and-evaluation-of-the-previous-red-blood-cell-indices-and-formulas-in-the-differentiation-between-beta-thalassemia-trait-and-iron-deficiency-anemia-in-the-makkah-region
#1
Amal Zaghloul, T A M A Al-Bukhari, Nada Bajuaifer, Maged Shalaby, H A Al-Pakistani, Saeed H Halawani, Shirin H Teama, Ghada A Wassif
BACKGROUND: Many formulas from red blood cell (RCB) indices are instructed to differentiate between iron deficiency anemia (IDA) and beta thalassemia trait. None had 100% Youden index. AIM OF THE WORK: To introduce two new formulas and evaluate them in the differentiation between IDA and beta thalassemia trait in adults Saudi (male and female; male; female) in the Makkah region. Furthermore, to evaluate the previous formulas in our population. METHODS: A total of 249 participants, 91 with IDA, 123 with beta thalassemia trait, and 35 healthy persons...
July 2016: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/26275252/sehgal-index-a-new-index-and-its-comparison-with-other-complete-blood-count-based-indices-for-screening-of-beta-thalassemia-trait-in-a-tertiary-care-hospital
#2
Kunal Sehgal, Preeti Mansukhani, Tina Dadu, Meher Irani, Shanaz Khodaiji
INTRODUCTION: Beta thalassemia trait (BTT) must be differentiated from iron deficiency anemia to avoid unnecessary iron therapy and for the prevention of thalassemia major by genetic counseling. In a tertiary care hospital, it is vital that the screening tool is not only sensitive but also specific so as to be cost effective and save time. AIM: The aim of this study was to evaluate the new Sehgal index and compare it to existing complete blood count-based indices for the best combination of sensitivity and specificity to predict BTT...
July 2015: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/26187724/hematinic-deficiencies-and-anemia-statuses-in-oral-mucosal-disease-patients-with-folic-acid-deficiency
#3
Julia Yu-Fong Chang, Yi-Ping Wang, Yang-Che Wu, Shih-Jung Cheng, Hsin-Ming Chen, Andy Sun
BACKGROUND/PURPOSE: Folic acid deficiency (FAD) may result in macrocytic anemia. This study assessed the hematinic deficiencies and anemia statuses in oral mucosal disease patients with FAD (defined as folic acid ≤ 6 ng/mL). METHODS: The blood hemoglobin (Hb), iron, vitamin B12, and folic acid concentrations, serum gastric parietal cell antibody level, and mean corpuscular volume (MCV) in 198 oral mucosal disease patients with FAD were measured. Based on World Health Organization (WHO) criteria, anemia or Hb deficiency was defined as having an Hb concentration of <13 g/dL for men and <12 g/dL for women...
September 2015: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/26076394/red-cell-indices-and-formulas-used-in-differentiation-of-%C3%AE-thalassemia-trait-from-iron-deficiency-in-thai-adults
#4
Soontharee Plengsuree, Manoo Punyamung, Jintana Yanola, Siriporn Nanta, Kanokwan Jaiping, Kritsanee Maneewong, Sanchai Wongwiwatthananukit, Sakorn Pornprasert
β-Thalassemia (β-thal) and iron deficiency cause most microcytic anemias. Red cell indices and formulas have been established as simple, fast, and inexpensive in discrimination between these two hematological disorders in school children. However, whether these formulas could be applied to diagnose β-thal trait and iron deficiency in adult Thai subjects is unclear. The aim of this study was to examine the diagnostic accuracy of five red cell indices [red blood cell (RBC) counts, mean corpuscular volume (MCV), mean corpuscular hemoglobin (Hb) (MCH), mean corpuscular Hb concentration (MCHC), and red cell distribution width (RDW)] and nine formulas (RDW/RBC, RDW Index, Sirdah, Green and King, Mentzer, England and Fraser, Ehsani, Srivastava and Shine and Lal)...
2015: Hemoglobin
https://www.readbyqxmd.com/read/25806419/screening-for-thalassemia-carriers-in-populations-with-a-high-rate-of-iron-deficiency-revisiting-the-applicability-of-the-mentzer-index-and-the-effect-of-iron-deficiency-on-hb-a2-levels
#5
Ali Amid, Bahram Haghi-Ashtiani, Melanie Kirby-Allen, Mohammad Taghi Haghi-Ashtiani
Differentiating between β-thalassemia (β-thal) minor and iron deficiency has important implications in thalassemia carrier screening. Several complete blood count (CBC)-based equations have been proposed for differentiating these two conditions. The applicability of these equations in populations with high rates of iron deficiency and β-thal minor, where patients can have both conditions, is limited. In addition, there have been conflicting reports on the possible effect of iron deficiency on Hb A2 level with possible consequences for thalassemia screening programs...
2015: Hemoglobin
https://www.readbyqxmd.com/read/24818016/hematological-indices-for-differential-diagnosis-of-beta-thalassemia-trait-and-iron-deficiency-anemia
#6
Aysel Vehapoglu, Gamze Ozgurhan, Ayşegul Dogan Demir, Selcuk Uzuner, Mustafa Atilla Nursoy, Serdar Turkmen, Arzu Kacan
Background. The two most frequent types of microcytic anemia are beta thalassemia trait ( β -TT) and iron deficiency anemia (IDA). We retrospectively evaluated the reliability of various indices for differential diagnosis of microcytosis and β -TT in the same patient groups. Methods. A total of 290 carefully selected children aged 1.1-16 years were evaluated. We calculated 12 discrimination indices in all patients with hemoglobin (Hb) values of 8.7-11.4 g/dL. None of the subjects had a combined case of IDA and β -TT...
2014: Anemia
https://www.readbyqxmd.com/read/24388269/oral-manifestations-and-blood-profile-in-patients-with-iron-deficiency-anemia
#7
Yang-Che Wu, Yi-Ping Wang, Julia Yu-Fong Chang, Shih-Jung Cheng, Hsin-Ming Chen, Andy Sun
BACKGROUND/PURPOSE: Iron deficiency anemia (IDA) is the most common type of anemia. This study evaluated whether IDA patients had specific oral manifestations and a particular blood profile compared to normal controls. METHODS: The oral manifestations and mean red blood cell (RBC) count, corpuscular cell volume, RBC distribution width, Mentzer index, and Green and King index as well as blood concentrations of hemoglobin, iron, total iron binding capacity, vitamin B12, folic acid, and homocysteine in 75 IDA patients and in 150 age- and sex-matched healthy controls were measured and compared...
February 2014: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/24139948/oral-manifestations-and-blood-profile-in-patients-with-thalassemia-trait
#8
Yi-Ping Wang, Julia Yu-Fong Chang, Yang-Che Wu, Shih-Jung Cheng, Hsin-Ming Chen, Andy Sun
BACKGROUND/PURPOSE: Patients with thalassemia trait (TT) may have anemia. This study evaluated whether TT patients had specific oral manifestations and a particular blood profile compared with normal individuals. METHODS: The oral manifestations and mean red blood cell count, corpuscular cell volume, red blood cell distribution width, Mentzer index, and Green and King index as well as blood concentrations of hemoglobin, iron, total iron binding capacity, vitamin B12, folic acid, and homocysteine in 65 TT patients and in 130 age- and sex-matched healthy controls were measured and compared...
December 2013: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/23800659/red-cell-indices-differentiation-between-%C3%AE-thalassemia-trait-and-iron-deficiency-anemia-and-application-to-sickle-cell-disease-and-sickle-cell-thalassemia
#9
Chaima Abdelhafidh Sahli, Amina Bibi, Faida Ouali, Sondess Hadj Fredj, Boutheina Dakhlaoui, Rym Othmani, Naouel Laouini, Latifa Jouini, Fekria Ouenniche, Hajer Siala, Imed Touhami, Mariem Becher, Slaheddine Fattoum, Nour El Houda Toumi, Taieb Messaoud
BACKGROUND: In Tunisia, thalassemia and sickle cell disease represent the most prevalent monogenic hemoglobin disorders with 2.21% and 1.89% of carriers, respectively. This study aims to evaluate the diagnosis reliability of a series of red blood cell indices and parameters in differentiation of beta-thalassemia trait (β-TT) from iron deficiency anemia (IDA) and between homozygous sickle cell disease (SS) and sickle cell-thalassemia (ST). METHODS: The study covered 384 patients divided into three groups...
November 2013: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/23492565/red-cell-indices-differentiation-between-%C3%AE-thalassemia-trait-and-iron-deficiency-anemia-and-application-to-sickle-cell-disease-and-sickle-cell-thalassemia
#10
Chaima A Sahli, Amina Bibi, Faida Ouali, Sondess Hadj Fredj, Boutheina Dakhlaoui, Rym Othmani, Naouel Laaouini, Latifa Jouini, Fekria Ouenniche, Hajer Siala, Imed Touhami, Mariem Becher, Slaheddine Fattoum, Nour El Houda Toumi, Taieb Messaoud
BACKGROUND: In Tunisia, thalassemia and sickle cell disease (SS) represent the most prevalent monogenic hemoglobin disorders with 2.21% and 1.89% of carriers, respectively. This study aims to evaluate the diagnosis reliability of 12 red blood cell (RBC) indices in differentiation of β-thalassemia trait (β-TT) from iron deficiency anemia (IDA) and between homozygous SS and sickle cell thalassemia (ST). METHODS: The study covered 384 patients divided into three groups...
August 2013: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/23321282/comparison-of-discriminative-indices-for-iron-deficiency-anemia-and-%C3%AE-thalassemia-trait-in-a-brazilian-population
#11
Januária Fonseca Matos, Luci Maria Sant'Ana Dusse, Rachel Versiani Bressane Stubbert, Mônica Ribeiro Ferreira, Wendel Coura-Vital, Ana Paula Salles Moura Fernandes, José Roberto de Faria, Karina Braga Gomes Borges, Maria das Graças Carvalho
To discriminate iron deficiency anemia (IDA) from β thalassemia trait (βTT), several indices obtained from modern blood count analyzers have been reported. Discrimination power of seven indices to differentiate between IDA and βTT, such as Green and King Index (GKI), RDW Index (RDWI), Srivastava Index (SRI), Mentzer Index (MI), Shine and Lal Index (SLI), Ehsani Index (EI), and Sirdah Index (SI), were evaluated. These indices were applied on 47 patients with βTT and on 289 patients with IDA, as confirmed by gold standard tests...
May 2013: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/22866672/indices-used-in-differentiation-of-thalassemia-trait-from-iron-deficiency-anemia-in-pediatric-population-are-they-reliable
#12
COMPARATIVE STUDY
Burçin Nalbantoğlu, Savaş Güzel, Volkan Büyükyalçın, M Metin Donma, Eda Çelik Güzel, Ayşin Nalbantoğlu, Erkut Karasu, Burcu Özdilek
BACKGROUND: Iron deficiency (IDA) and beta thalassemia trait (TT) are the most common causes of hypochromia and microcytosis. Many indices have been defined to quickly discriminate these similar entities via parameters obtained from automated blood cell analyzers. However, studies in the pediatric age group are scarce and their results are controversial. METHODS: We calculated eight discrimination indices [Mentzer Index (MI), England and Fraser Index (E&F), Srivastava Index (S), Green and King Index (G&K), Shine and Lal Index (S&L), red blood cell (RBC) count, RBC distribution width, and red blood cell distribution width Index (RDWI)] in 100 patients...
August 2012: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/22738220/poor-harvest-of-peripheral-blood-stem-cell-in-donors-with-microcytic-red-blood-cells
#13
Tso-Fu Wang, Shu-Huey Chen, Shang-Hsien Yang, Yu-Chieh Su, Sung-Chao Chu, Dian-Kun Li
BACKGROUND: The outcome of peripheral blood stem cell (PBSC) harvest depends on mobilization and leukapheresis. Some poor harvests might not be directly related to poor mobilizations. STUDY DESIGN AND METHODS: We retrospectively analyzed the results of 793 consecutive healthy donors who underwent PBSC donation to evaluate the impact of low mean corpuscular volume (MCV) of red blood cells on the outcomes of hematopoietic stem cell mobilization and leukapheresis. RESULTS: The circulating CD34+ cells in peripheral blood after five doses of granulocyte-colony-stimulating factor injection were similar in donors with low MCV and those with normal MCV (68...
January 2013: Transfusion
https://www.readbyqxmd.com/read/22455269/beta-thalassaemia-trait-haematological-parameters
#14
Yasar M Yousafzai, Shahtaj Khan, Fazle Raziq
BACKGROUND: Beta-Thalassaemia syndromes are a group of hereditary disorders characterised by a genetic deficiency in the synthesis of beta-globin chains due to a defect in beta-globin genes. The objective of this study was to determine the haematological features of beta-thalassaemia trait (BTT). and to determine the sensitivity of Mean Corpuscular Volume (MCV), Mean Corpuscular Haemoglobin (MCH) and Mentzer Index (ML) as a screening tool for beta-thalassaemia trait. METHODS: A descriptive study was conducted in Hayatabad Medical Complex, Peshawar from May 2009 to May 2010 with 203 subjects having BTT...
October 2010: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/21240173/role-of-discrimination-indices-in-differentiation-of-beta-thalassaemia-trait-and-iron-deficiency-anaemia
#15
A Nesa, S F Munir, T Sultana, M Q Rahman, A N Ahmed
Iron deficiency anaemia (IDA) and beta thalassaemia trait (BTT) are the most common causes of microcytic hypochromic anaemias. Several discrimination indices have been introduced to discriminate quickly these similar entities via parameters obtained from automated cell counter. The purpose of the study was to evaluate the value of five discrimination indices in differentiation of BTT and IDA. This study consists of 57 cases of BTT and 72 cases of IDA. Five discrimination indices evaluated in this study for differentiation of BTT and IDA were red blood cell (RBC) count, red blood cell distribution width index (RDWI), Green & King Index (G & K), Mentzer index (MI) and England & Fraser (E & F) index...
January 2011: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/20628316/evaluation-of-indices-in-differentiation-between-iron-deficiency-anemia-and-beta-thalassemia-trait-for-chinese-children
#16
Chuan Shen, Yong-mei Jiang, Hua Shi, Jin-hao Liu, Wen-jie Zhou, Qing-kai Dai, Hui Yang
Iron deficiency anemia (IDA) and beta-thalassemia trait (beta-TT) are the most common microcytic anemia. Kinds of discrimination indices have been established as simple, fast, and inexpensive means since 1970s. This study evaluates the validity of 12 indices in differentiation between IDA and beta-TT for Chinese children. The 12 discrimination indices were red blood cell (RBC) count, RBC distribution width, Mentzer Index, Green and King Index, RBC distribution width Index, England and Fraser Index, Shine and Lal Index, Srivastava Index, Ricerca Index, Ehsani Index, Sirdah Index, and Huber-Herklotz-Index...
August 2010: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/20423571/reliability-of-red-blood-cell-indices-and-formulas-to-discriminate-between-beta-thalassemia-trait-and-iron-deficiency-in-children
#17
COMPARATIVE STUDY
M Ferrara, L Capozzi, R Russo, F Bertocco, D Ferrara
Iron deficiency (ID) and beta thalassemia trait (betaTT) are the most common causes of hypochromia and microcytosis. This study evaluates the reliability of some of the red blood cell (RBC) indices and the formulas used in the differentiation between betaTT and ID in a cohort of 458 children aged between 1.8 and 7.5 years (mean age 5.6+/-1.7 years) with mild hypochromic microcytic anemia. Within this group, 243 were confirmed with ID and 215 with betaTT. Red cell indices derived from automated red cell analyzers were used to evaluate the following discriminant indices and formulas: Mentzer Index (MI), Green and King Index (G&K), England and Fraser Index (E&F), RBC Distribution Width Index (RDWI), RBC distribution width (RDW) and RBC count...
April 2010: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/20003131/approach-to-blood-donors-with-microcytosis
#18
A K Tiwari, I Chandola, A Ahuja
The aim of this paper is to find microcytosis in donors, to establish prevalence of iron deficiency anaemia (IDA) and beta-thalassemia trait (BTT) in them and to evaluate which index is most effective in differentiating these two conditions. IDA and BTT are the most common causes of microcytic anaemia. Traditional approach is trial of iron treatment. Where thalassemias are common, this can lead to iron overload and failure to provide diagnosis/counselling in BTT. Initially 925 donor samples were evaluated on cell counter...
April 2010: Transfusion Medicine
https://www.readbyqxmd.com/read/19579993/a-new-index-for-discrimination-between-iron-deficiency-anemia-and-beta-thalassemia-minor-results-in-284-patients
#19
M A Ehsani, E Shahgholi, M S Rahiminejad, F Seighali, A Rashidi
The present study reports the results in 284 patients of applying a recently developed index, MCV-(10 x RBC), for discrimination between beta-thalassemia trait (beta-TT) and Iron Deficiency Anemia (IDA), the two most common causes of microcytic hypochromic anemias. A total of 284 carefully selected patients (130 patients with IDA and 154 with beta-TT) were studied. Sensitivity, specificity and Youden's index were compared between the proposed index and four other indices, namely England-Fraser, Mentzer, Srivastava and RBC count...
March 1, 2009: Pakistan Journal of Biological Sciences: PJBS
https://www.readbyqxmd.com/read/19215670/red-cell-indices-and-functions-differentiating-patients-with-the-beta-thalassaemia-trait-from-those-with-iron-deficiency-anaemia
#20
V Okan, A Cigiloglu, S Cifci, M Yilmaz, M Pehlivan
This study examined the diagnostic accuracy of nine indices to discriminate between patients with mild-to-moderate (haemoglobin 8.5 - 11 g/dl) or moderate-to-severe (haemoglobin < 8.5 g/dl) iron deficiency anaemia (IDA) from those with beta-thalassaemia (beta-TT) (n = 100 per group). Indices examined were red blood cell (RBC) count, RBC distribution width (RDW), Mentzer index (MI), Shine and Lal index (S&L), England and Fraser index (E&F), Srivastava index (S), Green and King index (G&K), RDW index (RDWI), and Ricerca index (R)...
January 2009: Journal of International Medical Research
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