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https://www.readbyqxmd.com/read/29232376/che1-aatf-interacts-with-subunits-of-the-histone-acetyltransferase-core-module-of-saga-complexes
#1
Gizem Caliskan, Ikbal C Baris, Ferhan Ayaydin, Melanie J Dobson, Muge Senarisoy, Imre M Boros, Zeki Topcu, Sevil Zencir
General Control Non-derepressible 5 (GCN5) and Alteration/Deficiency in Activation 2 and 3 proteins (ADA2 and ADA3, respectively) are subunits of the Histone AcetylTransferase (HAT) module of SAGA- and ATAC-type co-activators. We previously reported four new interacting partners of human ADA3 identified by screening a human fetal brain cDNA library using yeast two hybrid technology. One of these partners was Apoptosis-Antagonizing Transcription Factor (AATF), also known as Che-1, an RNA polymerase II-binding protein with a number of roles in different cellular processes including regulation of transcription, cell proliferation, cell cycle control, DNA damage responses and apoptosis...
2017: PloS One
https://www.readbyqxmd.com/read/29232014/mutations-of-the-glycine-cleavage-system-genes-possibly-affect-the-negative-symptoms-of-schizophrenia-through-metabolomic-profile-changes
#2
Akane Yoshikawa, Fumichika Nishimura, Aya Inai, Yosuke Eriguchi, Masaki Nishioka, Atsuhiko Takaya, Mamoru Tochigi, Yoshiya Kawamura, Tadashi Umekage, Kayoko Kato, Tsukasa Sasaki, Yoshiaki Ohashi, Kazuya Iwamoto, Kiyoto Kasai, Chihiro Kakiuchi
AIM: Hypofunction of N-methyl-D-aspartate receptors (NMDARs) may contribute to the pathophysiology of schizophrenia (SCZ). Recently, the glycine cleavage system (GCS) was shown to affect NMDAR function in the brain. GCS functional defects cause nonketotic hyperglycinemia (NKH), the atypical phenotype of which presents psychiatric symptoms similar to SCZ. Here, we examined the involvement of GCS in SCZ. METHODS: First, to identify the rare variants and the exonic deletions, we re-sequenced all the coding exons and the splice sites of four GCS genes (GLDC, AMT, GCSH, DLD) in 474 patients with SCZ and 475 controls and performed multiplex ligation-dependent probe amplification (MLPA) analysis in SCZ...
December 12, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/29231805/understanding-host-parasite-relationship-the-immune-central-nervous-system-microenvironment-and-its-effect-on-brain-infections
#3
Laura Adalid-Peralta, Brenda Sáenz, Gladis Fragoso, Graciela Cárdenas
The central nervous system (CNS) has been recognized as an immunologically specialized microenvironment, where immune surveillance takes a distinctive character, and where delicate neuronal networks are sustained by anti-inflammatory factors that maintain local homeostasis. However, when a foreign agent such as a parasite establishes in the CNS, a set of immune defences is mounted and several immune molecules are released to promote an array of responses, which ultimately would control the infection and associated damage...
December 12, 2017: Parasitology
https://www.readbyqxmd.com/read/29231485/-he-xingwei-s-exploration-and-experience-in-the-pathogenesis-and-treatment-of-motor-impairment-of-the-trunk-after-stroke
#4
Peng Zhang, Songfeng Hu, Fan He, Jinying Fang, Qiang Wang, Xingwei He
In the paper, it is introduced professor HE Xingwei's recognition on the pathogenesis and professor HE's experience in the treatment of the motor impairment of the trunk after stroke. Professor He believes that the motor impairment of the trunk after stroke is the essential factor affecting the rehabilitation in stroke. The motor impairment of the trunk after stroke results from brain marrow damage and spiritual impairment. Hence, regaining the consciousness and promoting the circulation of the governor vessel are the basic principles of the treatment, named regulating the mind and controlling qi, benefiting qi and warming yang, tonifying the kidney and filling up the essence, and promoting the circulation of the governor vessel...
February 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29231439/-professor-lai-xinsheng-s-clinical-experience-in-the-treatment-of-premature-ovarian-failure-with-tongyuan-acupuncture-technique-and-chinese-herbal-medicine
#5
Xiaozhe Li, Sujuan Zhang
In the treatment of premature ovarian failure (POF), professor LAI Xinsheng focuses on the determination of syndrome to seek for etiology, associating with the differentiation of meridian and collateral and that of zangfu organs. Professor LAI believes that POF is mainly manifested as amenorrhea and infertility, localized in the kidney, with the dysfunction of liver, spleen and heart. It is impacted by many pathological factors, such as cold blockage, qi stagnation, blood stagnation, blood deficiency, yin deficiency, etc...
March 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29230595/an-optimized-technique-of-endoscopic-third-ventriculocisternostomy-etv-for-children-with-occlusive-hydrocephalus
#6
Albert Akramovich Sufianov, Ekkehard M Kasper, Rinat Albertovich Sufianov
In this article, we present an optimized minimally invasive technique of ETV for children with occlusive hydrocephalus. The study comprises of 64 consecutive pediatric cases (34 boys and 30 girls aged from 1 month to 5 years) of occlusive hydrocephalus from various etiologies, which were treated with a modified technique of ETV. Mean clinical follow-up period after ETV was 24.2 ± 3.8 months. Application of the new technique made it possible to significantly reduce the length of the soft tissue incision for access, and the use of upgraded instruments allowed to perform a twist drill hole in the skull to less than half a usual size...
December 11, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/29230520/ipsilesional-functional-recruitment-within-lower-mu-band-in-children-with-unilateral-cerebral-palsy-an-event-related-desynchronization-study
#7
Alberto Inuggi, Michela Bassolino, Chiara Tacchino, Valentina Pippo, Valeria Bergamaschi, Claudio Campus, Valentina De Franchis, Thierry Pozzo, Paolo Moretti
Cerebral palsy (CP) is a group of non-progressive developmental movement disorders inducing a strong brain reorganization in primary and secondary motor areas. Nevertheless, few studies have been dedicated to quantify brain pattern changes and correlate them with motor characteristics in CP children. In this context, it is very important to identify feasible and complementary tools able to enrich the description of motor impairments by considering their neural correlates. To this aim, we recorded the electroencephalographic activity and the corresponding event-related desynchronization (ERD) of a group of mild-to-moderate affected unilateral CP children while performing unilateral reach-to-grasp movements with both their paretic and non-paretic arms...
December 11, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/29230507/evidence-for-regional-hippocampal-damage-in-patients-with-schizophrenia
#8
Sadhana Singh, Subash Khushu, Pawan Kumar, Satnam Goyal, Triptish Bhatia, Smita N Deshpande
PURPOSE: Schizophrenia patients show cognitive and mood impairments, including memory loss and depression, suggesting damage in the brain regions. The hippocampus is a brain structure that is significantly involved in memory and mood function and shows impairment in schizophrenia. In the present study, we examined the regional hippocampal changes in schizophrenia patients using voxel-based morphometry (VBM), Freesurfer, and proton magnetic resonance spectroscopy (1H MRS) procedures. METHODS: 1H MRS and high-resolution T1-weighted magnetic resonance imaging were collected in both healthy control subjects (N = 28) and schizophrenia patients (N = 28) using 3-Tesla whole body MRI system...
December 11, 2017: Neuroradiology
https://www.readbyqxmd.com/read/29230325/a-study-on-knowledge-awareness-and-medication-adherence-in-patients-with-hypertension-from-a-tertiary-care-centre-from-northern-sri-lanka
#9
S Pirasath, T Kumanan, M Guruparan
Objective: To assess the patient's knowledge and awareness about hypertension and adherence to antihypertensive medication among hypertensive patients with validated Morisky questionnaires in a tertiary care centre of northern Sri Lanka. Methods: A cross-sectional descriptive comparative study was carried out at Teaching Hospital Jaffna, from January 2017 to April 2017. Hypertensive patients were recruited by systematic randomized controlled sampling and interviewed with validated Morisky questionnaires to assess their knowledge about hypertension...
2017: International Journal of Hypertension
https://www.readbyqxmd.com/read/29230100/dl-3-n-butylphthalide-prevents-the-disruption-of-blood-spinal-cord-barrier-via-inhibiting-endoplasmic-reticulum-stress-following-spinal-cord-injury
#10
Binbin Zheng, Yulong Zhou, Hongyu Zhang, Guangyong Yang, Zhenghua Hong, Dandan Han, Qingqing Wang, Zili He, Yanlong Liu, Fenzan Wu, Xie Zhang, Songlin Tong, Huazi Xu, Jian Xiao
After spinal cord injury (SCI), the destruction of blood-spinal cord barrier (BSCB) is shown to accelerate gathering of noxious blood-derived components in the nervous system, leading to secondary neurodegenerative damages. SCI activates endoplasmic reticulum stress (ER stress), which is considered to evoke secondary damages of neurons and glia. Recent evidence indicates that Dl-3-n-butylphthalide (NBP) has the neuroprotective effect in ischaemic brain injury, but whether it has protective effects on SCI or not is largely unclear...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/29229965/transfer-of-minibeam-radiation-therapy-into-a-cost-effective-equipment-for-radiobiological-studies-a-proof-of-concept
#11
Y Prezado, M Dos Santos, W Gonzalez, G Jouvion, C Guardiola, S Heinrich, D Labiod, M Juchaux, L Jourdain, C Sebrie, F Pouzoulet
Minibeam radiation therapy (MBRT) is an innovative synchrotron radiotherapy technique able to shift the normal tissue complication probability curves to significantly higher doses. However, its exploration was hindered due to the limited and expensive beamtime at synchrotrons. The aim of this work was to develop a cost-effective equipment to perform systematic radiobiological studies in view of MBRT. Tumor control for various tumor entities will be addressable as well as studies to unravel the distinct biological mechanisms involved in normal and tumor tissues responses when applying MBRT...
December 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29229555/reduced-cerebrovascular-reactivity-and-increased-resting-cerebral-perfusion-in-rats-exposed-to-a-cafeteria-diet
#12
Mariana Gomez-Smith, Rafal Janik, Evelyn M Lake, Lynsie A M Thomason, Conner Adams, Matthew S Jeffers, Bojana Stefanovic, Dale Corbett
To better understand the effects of a diet high in fat, sugar, and sodium on cerebrovascular function, Sprague Dawley rats were chronically exposed to a Cafeteria diet. Resting cerebral perfusion and cerebrovascular reactivity were quantified using continuous arterial spin labeling (CASL) magnetic resonance imaging (MRI). In addition, structural changes to the cerebrovasculature and susceptibility to ischemic lesion were examined. Compared to control animals fed standard chow (SD), Cafeteria diet (CAF) rats exhibited increased resting brain perfusion in the hippocampus and reduced cerebrovascular reactivity in response to 10% inspired CO2 challenges in both the hippocampus and the neocortex...
December 8, 2017: Neuroscience
https://www.readbyqxmd.com/read/29229397/di-acetyl-creatine-ethyl-ester-a-new-creatine-derivative-for-the-possible-treatment-of-creatine-transporter-deficiency
#13
Enrico Adriano, Maurizio Gulino, Maria Arkel, Annalisa Salis, Gianluca Damonte, Nara Liessi, Enrico Millo, Patrizia Garbati, Maurizio Balestrino
Creatine is pivotal in energy metabolism of the brain. In primary creatine deficiency syndromes, creatine is missing from the brain. Two of them (AGAT and GAMT deficiency) are due to impaired creatine synthesis, and can be treated by creatine supplementation. By contrast, creatine transporter deficiency cannot be treated by such supplementation, since creatine crossing of biological membranes (plasma membrane and blood-brain barrier) is dependent on its transporter. This problem might be overcome by modifying the creatine molecule to allow it to cross biological membranes independently of its transporter...
December 8, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29229228/factors-influencing-norvancomycin-concentration-in-plasma-and-cerebrospinal-fluid-in-patients-after-craniotomy-and-dosing-guideline-a-population-approach
#14
Xingang Li, Yuanxing Wu, Shusen Sun, Qiang Wang, Zhigang Zhao
PURPOSE: Antibacterial spectrum and activity of norvancomycin are comparable with vancomycin, and it has been widely used in China. Norvancomycin can penetrate into the cerebrospinal fluid (CSF) through the damaged blood-brain barrier in patients after craniotomy. Because higher inter-individual variability was observed, we aimed to identify factors related to drug concentration to guide clinicians with norvancomycin dosing. METHODS: After craniotomy, patients with an indwelling catheter in the operational area/ventricle were intravenously administered norvancomycin...
December 8, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/29228858/common-patterns-of-regional-brain-injury-detectable-by-dti-in-otherwise-normal-appearing-white-matter-in-patients-with-early-moderate-to-severe-traumatic-brain-injury
#15
Kristine O'Phelan, Chad Kuniyuki Otoshi, Thomas M Ernst, Linda Chang
Traumatic brain injury (TBI) alters the lives of millions of people every year. Although mortality rates have improved, due to better prehospital care and reduction of secondary injury in the critical care setting, improvements in functional outcomes after TBI have been difficult to achieve. Diffusion-tensor imaging (DTI) allows detailed measurement of microstructural damage in regional brain tissue after TBI, thus improving our understanding of the extent and severity of TBI. METHODS: Twenty subjects were recruited from a Neurological Intensive Care Unit, and compared to 18 healthy control subjects...
December 11, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29228704/role-of-hif-1a-in-regulating-autophagic-cell-survival-during-cerebral-ischemia-reperfusion-in-rats
#16
Yongqing Guo
Hypoxia-inducible factor-1a (HIF-1a) plays a beneficial role during cerebral ischemia reperfusion (IR), but the underlying molecular mechanisms are not completely understood. Here, we aimed to investigate the effects and molecular regulation of HIF-1a on brain cell apoptosis and autophagy during IR. We found that augmentation of HIF-1a in re-perfused hematopoietic cells significantly reduced brain damage, alleviated brain edema and improved neural function during IR, seemingly through two HIF-1a target genes BNIP3 and NIX, which were critical regulators for cell apoptosis and autophagic cell survival...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29228667/metformin-ameliorates-sepsis-induced-brain-injury-by-inhibiting-apoptosis-oxidative-stress-and-neuroinflammation-via-the-pi3k-akt-signaling-pathway
#17
Guangming Tang, Huiyun Yang, Jing Chen, Mengrao Shi, Lingqing Ge, Xuhua Ge, Guoji Zhu
Sepsis-induced brain injuries increase mortality, morbidity, cognitive impairment and lack of effective therapeutic treatment. Previous studies have suggested that metformin provides neuroprotective effects against ischemia, brain trauma and other brain damage, but whether metformin protects a septic brain remains unknown. Thus, the aim of this study is to investigate the possible effects and the mechanism of metformin against septic brain damage using the cecal ligation and puncture (CLP) model. Mice were randomly divided into five groups: the Sham group, CLP group, CLP+ Met group, CLP+ vehicle group and CLP+ Met+ LY group...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29228610/targeting-polo-like-kinase-1-in-smarcb1-deleted-atypical-teratoid-rhabdoid-tumor
#18
Irina Alimova, Angela M Pierce, Peter Harris, Andrew Donson, Diane K Birks, Eric Prince, Ilango Balakrishnan, Nicholas K Foreman, Marcel Kool, Lindsey Hoffman, Sujatha Venkataraman, Rajeev Vibhakar
Atypical teratoid rhabdoid tumor (ATRT) is an aggressive and malignant pediatric brain tumor. Polo-like kinase 1 (PLK1) is highly expressed in many cancers and essential for mitosis. Overexpression of PLK1 promotes chromosome instability and aneuploidy by overriding the G2-M DNA damage and spindle checkpoints. Recent studies suggest that targeting PLK1 by small molecule inhibitors is a promising approach to tumor therapy. We investigated the effect of PLK1 inhibition in ATRT. Gene expression analysis showed that PLK1 was overexpressed in ATRT patient samples and tumor cell lines...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29228550/regulation-of-xpc-deubiquitination-by-usp11-in-repair-of-uv-induced-dna-damage
#19
Palak Shah, Lei Qiang, Seungwon Yang, Keyoumars Soltani, Yu-Ying He
Nucleotide excision repair (NER) is the most versatile DNA repair pathway for removing DNA damage caused by UV radiation and many environmental carcinogens. NER is essential for suppressing tumorigenesis in the skin, lungs and brain. Although the core NER proteins have been identified and characterized, molecular regulation of NER remains poorly understood. Here we show that ubiquitin-specific peptidase 11 (USP11) positively regulates NER by deubiquitinating xeroderma pigmentosum complementation group C (XPC) and promoting its retention at the DNA damage sites...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29228445/the-protective-effect-and-its-mechanism-of-3-n-butylphthalide-pretreatment-on-cerebral-ischemia-reperfusion-injury-in-rats
#20
R-Y Yan, S-J Wang, G-T Yao, Z-G Liu, N Xiao
OBJECTIVE: To investigate the potential effect of 3-n-butylphthalide (NBP) pretreatment on the cerebral ischemia/reperfusion injury in rats and the relevant mechanism. MATERIALS AND METHODS: A total of 90 rats was divided into three groups: Sham operation group (Sham group), ischemia-reperfusion group (I-R group), and NBP pretreatment group (NBP group 75 mg·kg-1·d-1 gavage). Pre-treatment was given once a day within 1 week before establishing the rat model of cerebral ischemia-reperfusion injury...
November 2017: European Review for Medical and Pharmacological Sciences
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