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https://www.readbyqxmd.com/read/29792096/neonatal-outcome-in-preterm-deliveries-before-34-week-gestation-the-influence-of-the-mechanism-of-labor-onset
#1
Sara Pinto, Maria Filipa Malheiro, Ana Vaz, Teresa Rodrigues, Nuno Montenegro, Hercília Guimarães
PURPOSE: To evaluate neonatal outcomes in preterm infants with less than 34 weeks after spontaneous labor, preterm premature rupture of membranes (PPROM) or iatrogenic delivery and to clarify whether the mechanism of labor onset is a risk factor for adverse short-term neonatal outcome. METHODS: We performed a retrospective case-control study, which included 266 preterm newborns with less than 34-week gestation, between 2011 and 2015. Neonatal outcomes were compared according to the mechanism of labor onset...
May 23, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29789058/prevention-and-treatment-of-respiratory-distress-syndrome-in-preterm-neonates
#2
Christopher McPherson, Jennifer A Wambach
Respiratory distress syndrome (RDS) impacts a high proportion of preterm neonates, resulting in significant morbidity and mortality. Advances in pharmacotherapy, specifically antenatal corticosteroids and postnatal surfactant therapy, have significantly reduced the incidence and impact of neonatal RDS. Antenatal corticosteroids accelerate fetal lung maturation by increasing the activity of enzymes responsible for surfactant biosynthesis, resulting in improved lung compliance. Maternal antenatal corticosteroid treatment has improved survival of preterm neonates and lowered the incidence of brain injury...
May 1, 2018: Neonatal Network: NN
https://www.readbyqxmd.com/read/29788899/topical-nanostructured-lipid-carrier-based-hydrogel-of-mometasone-furoate-for-the-treatment-of-psoriasis
#3
Navjot Kaur, Kusha Sharma, Neena Bedi
OBJECTIVE: The aim of the present study was to develop and evaluate nanostructured lipid carrier based topical hydrogel of mometasone furoate for the treatment of psoriasis. METHODS: Drug loaded NLCs were successfully developed by microemulsion technique. Pseudo ternary phase diagrams were constructed using different combinations of surfactant and co-surfactants to study the microemulsion existence range. Different compositions were selected from the phase diagram showing maximum microemulsion region and were converted into NLCs by dilution in water (1:20)...
May 22, 2018: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/29788881/novel-solid-lipid-nanocarrier-of-glibenclamide-a-factorial-design-approach-with-response-surface-methodology
#4
Sonia Pandey, Payal Patel, Arti Gupta
BACKGROUND: In the present investigation a factorial design approach attempt was applied to develop the solid lipid nanoparticles (SLN) of Glibenclamide (GLB) a poorly water-soluble drug (BCS -II) used in the treatment of type 2 diabetes. OBJECTIVES: Prime objectives of this experiment are to optimize the SLN formulation of Glibenclamide and improve the therapeutic effectiveness of the developed formulation. METHODS: Glibenclamide loaded SLNs (GLB-SLN) were fabricated by High speed homogenization technique...
May 21, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29780787/non-convulsive-seizure-related-to-cremophor-el%C3%A2-free-polymeric-micelle-formulation-of-paclitaxel-a-case-report
#5
Yoon Sun Shin, Kyung Jin Min, Seung Young Choi, Nak Woo Lee
Paclitaxel is a chemotherapeutic agent that is effective against ovarian, breast, lung, and other cancers. Although peripheral neurotoxicity is among the most common side effects of paclitaxel treatment, central neurotoxicity is rarely reported. When centrally mediated side effects are observed, they are attributed to Cremophor EL™ (CrEL), a surfactant-containing vehicle used for paclitaxel administration. In the present report, we discuss the case of a 72-year-old woman with ovarian carcinoma who experienced a non-convulsive seizure following administration of a CrEL-free, polymeric micelle formulation of paclitaxel...
May 2018: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/29777772/improving-maraviroc-oral-bioavailability-by-formation-of-solid-drug-nanoparticles
#6
Alison C Savage, Lee M Tatham, Marco Siccardi, Trevor Scott, Manoli Vourvahis, Andrew Clark, Steve P Rannard, Andrew Owen
Oral drug administration remains the preferred approach for treatment of HIV in most patients. Maraviroc (MVC) is the first in class co-receptor antagonist, which blocks HIV entry into host cells. MVC has an oral bioavailability of approximately 33%, which is limited by poor permeability as well as affinity for CYP3A and several drug transporters. While once-daily doses are now the favoured option for HIV therapy, dose-limiting postural hypotension has been of theoretical concern when administering doses high enough to achieve this for MVC (particularly during coadministration of enzyme inhibitors)...
May 16, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29771610/tracheal-acid-or-surfactant-instillation-raises-alveolar-surface-tension
#7
Tam L Nguyen, Carrie E Perlman
Whether alveolar liquid surface tension, T, is elevated in the acute respiratory distress syndrome (ARDS) has not been demonstrated in situ in the lungs. Neither is it known how exogenous surfactant, which has failed to treat ARDS, affects in situ T. We aim to determine T in an acid-aspiration ARDS model before and after exogenous surfactant administration. In isolated rat lungs, we combine servo-nulling pressure measurement and confocal microscopy to determine alveolar liquid T according to the Laplace relation...
May 17, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29762231/surfactant-administration-during-pediatric-cardiac-extracorporeal-membrane-oxygenation
#8
Constantinos Chrysostomou, Timothy Maul, Filip Istvanic, Peter Wearden
We investigated the safety and efficacy of surfactant during extracorporeal membrane oxygenation (ECMO) in children with cardiac disease. ECMO patients administered surfactant (surfactant group) were compared with patients who did not receive (control). Criteria to administer surfactant were based on a decreased lung compliance of <0.5 ml/kg/cm H2O. Efficacy was determined on pulmonary compliance change and the radiography-based respiratory distress severity (RDS) score. For the surfactant group, lung compliance measurements and RDS scores were obtained just before the first surfactant administration (T0), 24 hours after the last dose of surfactant (T1), and 24 hours after ECMO decannulation (T2)...
May 11, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29745729/anti-proliferate-and-apoptosis-triggering-potential-of-methotrexate-transferrin-conjugate-encapsulated-plga-nanoparticles-with-enhanced-cellular-uptake-by-high-affinity-folate-receptors
#9
Ankush Parmar, Atul Jain, Shivani Uppal, S K Mehta, Khuswinder Kaur, Bhupinder Singh, Rajat Sandhir, Shweta Sharma
The objective of the present study is to enhance the permeation of bioactive molecules across highly lipophilic insurmountable blood brain barrier (BBB) using folic acid (FA) functionalized poly(lactic-co-glycolic acid) (PLGA) nanoparticles (FA-PNPs) coated with non-ionic surfactant, Polysorbate 80 (P80 ). The developed Mtx-Tf loaded folic acid anchored PNPs formulation depicted particle size, zeta potential and entrapment efficiency of 109 ± 2.3 nm, -9.38 ± 0.9 mV and 71.0 ± 0.6%, respectively...
May 10, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29731780/lung-mesenchymal-stem-cells-ameliorate-elastase-induced-damage-in-an-animal-model-of-emphysema
#10
Donato Cappetta, Antonella De Angelis, Giuseppe Spaziano, Gioia Tartaglione, Elena Piegari, Grazia Esposito, Loreta Pia Ciuffreda, Angela Liparulo, Manuela Sgambato, Teresa Palmira Russo, Francesco Rossi, Liberato Berrino, Konrad Urbanek, Bruno D'Agostino
Pulmonary emphysema is a respiratory condition characterized by alveolar destruction that leads to airflow limitation and reduced lung function. Although with extensive research, the pathophysiology of emphysema is poorly understood and effective treatments are still missing. Evidence suggests that mesenchymal stem cells (MSCs) possess the ability to engraft the injured tissues and induce repair via a paracrine effect. Thus, the aim of this study was to test the effects of the intratracheal administration of lung-derived mouse MSCs in a model of elastase-induced emphysema...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29721078/localized-delivery-of-curcumin-into-brain-with-polysorbate-80-modified-cerasomes-by-ultrasound-targeted-microbubble-destruction-for-improved-parkinson-s-disease-therapy
#11
Nisi Zhang, Fei Yan, Xiaolong Liang, Manxiang Wu, Yuanyuan Shen, Min Chen, Yunxue Xu, Guangyang Zou, Peng Jiang, Caiyun Tang, Hairong Zheng, Zhifei Dai
Rationale: Treatment for Parkinson's disease (PD) is challenged by the presence of the blood-brain barrier (BBB) that significantly limits the effective drug concentration in a patient's brain for therapeutic response throughout various stages of PD. Curcumin holds the potential for α-synuclein clearance to treat PD; however, its applications are still limited due to its low bioavailability and poor permeability through the BBB in a free form. Methods: Herein, this paper fabricated curcumin-loaded polysorbate 80-modified cerasome (CPC) nanoparticles (NPs) with a mean diameter of ~110 nm for enhancing the localized curcumin delivery into the targeted brain nuclei via effective BBB opening in combination with ultrasound-targeted microbubble destruction (UTMD)...
2018: Theranostics
https://www.readbyqxmd.com/read/29720917/comparison-of-the-pharmacoeconomics-of-calfactant-and-poractant-alfa-in-surfactant-replacement-erapy
#12
Michael M Zayek, Fabien G Eyal, Robert C Smith
OBJECTIVE: To compare the pharmacy costs of calfactant (Infasurf, ONY, Inc.) and poractant alfa (Curosurf, Chiesi USA, Inc., Cary, NC). METHODS: The University of South Alabama Children's and Women's Hospital switched from calfactant to poractant alfa in 2013 and back to calfactant in 2015. Retrospectively, we used deidentified data from pharmacy records that provided type of surfactant administered, gestational age, birth weight, and number of doses on each patient...
March 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/29717157/effective-in-vivo-treatment-of-acute-lung-injury-with-helical-amphipathic-peptoid-mimics-of-pulmonary-surfactant-proteins
#13
Ann M Czyzewski, Lynda M McCaig, Michelle T Dohm, Lauren A Broering, Li-Juan Yao, Nathan J Brown, Maruti K Didwania, Jennifer S Lin, Jim F Lewis, Ruud Veldhuizen, Annelise E Barron
Acute lung injury (ALI) leads to progressive loss of breathing capacity and hypoxemia, as well as pulmonary surfactant dysfunction. ALI's pathogenesis and management are complex, and it is a significant cause of morbidity and mortality worldwide. Exogenous surfactant therapy, even for research purposes, is impractical for adults because of the high cost of current surfactant preparations. Prior in vitro work has shown that poly-N-substituted glycines (peptoids), in a biomimetic lipid mixture, emulate key biophysical activities of lung surfactant proteins B and C at the air-water interface...
May 1, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29705119/relationship-between-epigenetic-maturity-and-respiratory-morbidity-in-preterm-infants
#14
Anna K Knight, Alicia K Smith, Karen N Conneely, Philippa Dalach, Yuk J Loke, Jeanie L Cheong, Peter G Davis, Jeffrey M Craig, Lex W Doyle, Christiane Theda
OBJECTIVE: To assess associations between epigenetic maturity of extremely preterm babies (born at less than 28 weeks of gestation), neonatal interventions, and respiratory outcomes, including the administration of surfactant and postnatal corticosteroids, duration of assisted ventilation, and development of bronchopulmonary dysplasia (BPD). STUDY DESIGN: DNA was extracted from neonatal blood spots collected after birth from 143 extremely preterm infants born 1991-1992 in Victoria, Australia and used to determined DNA methylation (DNAm)...
April 25, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29694989/is-less-invasive-surfactant-administration-necessary-or-only-helpful-or-just-a-fashion
#15
Gianluca Lista, Ilia Bresesti, Laura Fabbri
In the 1990s, the most relevant pillars in the treatment of neonatal respiratory distress syndrome (RDS) have been improvements in ventilation strategies, the introduction of exogenous surfactant replacement therapy, and the use of antenatal steroids. Lately, in addition to the standard INSURE (INtubation-SURfactant administration-Extubation) method to administer surfactant, a new technique has been gaining increasing popularity. It is the so-called less invasive surfactant administration (LISA) method, which has shown promising results in preventing bronchopulmonary dysplasia development and in reducing mortality in preterm neonates...
May 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29689490/penetration-of-antimicrobial-peptides-in-a-lung-surfactant-model
#16
L M P Souza, J B Nascimento, A L Romeu, E D Estrada-López, A S Pimentel
Molecular dynamics simulations were successfully performed to understand the absorption mechanism of antimicrobial peptides LL-37, CATH-2, and SMAP-29 in a lung surfactant model. The antimicrobial peptides quickly penetrate in the lung surfactant model in dozens or hundreds nanoseconds, but they electrostatically interact with the lipid polar heads during the simulation time of 2 μs. This electrostatic interaction should be the explanation for the inactivation of the antimicrobial peptides when co-administrated with lung surfactant...
April 19, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29684533/lipid-coated-mannitol-core-microparticles-for-sustained-release-of-protein
#17
Bifeng Wang, Wolfgang Friess
Parenteral sustained release systems for proteins which provide therapeutic levels over a longer period avoiding frequent administration, which preserve protein stability during manufacturing, storage and application and which are biodegradable and highly biocompatible in the body are intensively sought after. The aim of this study was to generate and study mannitol core microparticles loaded with a monoclonal antibody IgG1 and coated with lipid either hard fat or glyceryl stearate at different coating levels...
April 20, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29680503/chitosan-tailored-lipidic-nanoconstructs-of-fusidic-acid-as-promising-vehicle-for-wound-infections-an-explorative-study
#18
Kanika Thakur, Gajanand Sharma, Bhupinder Singh, Sanjay Chhibber, A B Patil, Om Prakash Katare
The current research study intends to explore the combined potential of lipid nanoparticles and chitosan as an optimum therapy for the management of wound infections. Fusidic acid (FA), a steroidal antibiotic employed for treatment of primary and secondary topical infections was encapsulated within the nanoengineered lipid-polymer hybrid nanoparticles (FA-LPHNs). A number of variables like lipid/polymer ratio, lipid, surfactant and chitosan concentration, stirring speed were optimized to get the desired particle size and % entrapment efficiency...
April 19, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29665153/in-situ-self-assembling-micellar-depots-that-can-actively-trap-and-passively-release-no-with-long-lasting-activity-to-reverse-osteoporosis
#19
Yu-Jung Lin, Chun-Chieh Chen, Nai-Wen Chi, Trang Nguyen, Hung-Yun Lu, Dang Nguyen, Po-Liang Lai, Hsing-Wen Sung
Treatment with exogenous nitric oxide (NO) donors is regarded as being effective against osteoporosis. However, NO has a short half-life, limiting its clinical usefulness. To overcome this limitation, an injectable microparticle (MP) system is developed that consists of phase-change materials capric acid (CA) and octadecane, and encapsulates a NO donor. The therapeutic efficacy of the MPs is evaluated in ovariectomized (OVX) rats with osteoporosis. Upon subcutaneous administration, the MPs undergo a phase transition, leaching out the NO donor and generating NO bubbles that are instantly covered by a layer of tightly packed CA surfactant molecules, forming micellar depots...
April 17, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29662925/factors-associated-with-improvements-in-mortality-and-morbidity-rates-of-very-low-birth-weight-infants-a-cohort-study
#20
Giancarlo Mari, Zoran Bursac, Patricia Jean Goedecke, Ramasubbareddy Dhanireddy
Objective . The objective of this study was to determine factors contributing to improvements in infant mortality rates (IMR) and composite morbidity-mortality in very-low-birth-weight (VLBW) infants after initiating a new perinatal program in 2009 at Regional One Health (ROH). VLBW infants account for 67% of infant deaths. Design . This is a pre-/postintervention cohort study of prospectively gathered data. Population . VLBW infants delivered at ROH during the 2004 to 2015 study period. Setting . ROH is a Regional Perinatal Center affiliated with the University of Tennessee Health Science Center...
2018: Global Pediatric Health
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