keyword
MENU ▼
Read by QxMD icon Read
search

surfactant administration

keyword
https://www.readbyqxmd.com/read/27910752/submicron-emulsions-and-their-applications-in-oral-delivery
#1
Veenu Mundada, Mitali Patel, Krutika Sawant
A "submicron emulsion" is an isotropic mixture of drug, lipids, and surfactants, usually with hydrophilic cosolvents and with droplet diameters ranging from 10 to 500 nm. Submicron emulsions are of increasing interest in medicine due to their kinetic stability, high solubilizing capacity, and tiny globule size. Because of these properties, they have been applied in various fields, such as personal care, cosmetics, health care, pharmaceuticals, and agrochemicals. Submicron emulsions are by far the most advanced nanoparticulate systems for the systemic delivery of biologically active agents for controlled drug delivery and targeting...
2016: Critical Reviews in Therapeutic Drug Carrier Systems
https://www.readbyqxmd.com/read/27877020/improved-oral-bioavailability-of-20-r-25-methoxyl-dammarane-3%C3%AE-12%C3%AE-20-triol-using-nanoemulsion-based-on-phospholipid-complex-design-characterization-and-in-vivo-pharmacokinetics-in-rats
#2
Xiangrong Zhang, Yi Zhang, Shuang Guo, Feifei Bai, Tong Wu, Yuqing Zhao
The aim of the study was to improve the oral absorption of the compound 25-OCH3-PPD with poor hydrophilicity and lipophilicity. 25-OCH3-PPD-phospholipid complex was prepared by solvent evaporation, then characterized by differential scanning calorimetry, scanning electron microscopy, and infrared absorption spectroscopy. The aqueous solubility and oil-water partition coefficient were compared with the free compound. A nanoemulsion loaded with 25-OCH3-PPD-phospholipid complex was developed by dissolving the complex in water in the presence of hydrophilic surfactant under sonication...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27876355/lung-protective-ventilatory-strategies-in-intubated-preterm-neonates-with-rds
#3
REVIEW
F Reiterer, B Schwaberger, T Freidl, G Schmölzer, G Pichler, B Urlesberger
This article provides a narrative review of lung-protective ventilatory strategies (LPVS) in intubated preterm infants with RDS. A description of strategies is followed by results on short-and long-term respiratory and neurodevelopmental outcomes. Strategies will include patient-triggered or synchronized ventilation, volume targeted ventilation, the technique of intubation, surfactant administration and rapid extubation to NCPAP (INSURE), the open lung concept, strategies of high-frequency ventilation, and permissive hypercapnia...
October 26, 2016: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/27866188/feasibility-of-laryngeal-mask-airway-device-placement-in-neonates
#4
Amanda A Wanous, Andrew Wey, Kyle D Rudser, Kari D Roberts
BACKGROUND: The laryngeal mask airway (LMA) has been used in adult and pediatric populations for decades. While the familiarity of its use in the neonatal population is increasing, there are few data investigating this. OBJECTIVE: The objective of this study was to determine the feasibility of LMA placement in neonates by investigating the time and number of attempts required for successful placement and physiologic stability during the placement of the device. METHODS: This study is one component of a national, multicenter, randomized controlled trial investigating surfactant administration through an LMA in neonates...
November 19, 2016: Neonatology
https://www.readbyqxmd.com/read/27863989/the-gut-in-the-beaker-missing-the-surfactants
#5
REVIEW
Clive G Wilson, Gavin W Halbert, Jenifer Mains
Gastrointestinal drug administration is the preferred route for the majority of drugs however, the natural physiology and physicochemistry of the gastrointestinal tract is critical to absorption but complex and influenced by factors such as diet or disease. The pharmaceutical sciences drive for product consistency has led to the development of in vitro product performance tests whose utility and interpretation is hindered by the complexity, variability and a lack of understanding. This article explores some of these issues with respect to the drug, formulation and the presence of surfactant excipients and how these interact with the natural bile salt surfactants...
October 15, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27863685/the-gut-in-the-beaker-missing-the-surfactants
#6
REVIEW
Clive G Wilson, Gavin W Halbert, Jenifer Mains
Gastrointestinal drug administration is the preferred route for the majority of drugs however, the natural physiology and physicochemistry of the gastrointestinal tract is critical to absorption but complex and influenced by factors such as diet or disease. The pharmaceutical sciences drive for product consistency has led to the development of in vitro product performance tests whose utility and interpretation is hindered by the complexity, variability and a lack of understanding. This article explores some of these issues with respect to the drug, formulation and the presence of surfactant excipients and how these interact with the natural bile salt surfactants...
November 30, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27852668/less-invasive-surfactant-administration-versus-intubation-for-surfactant-delivery-in-preterm-infants-with-respiratory-distress-syndrome-a-systematic-review-and-meta-analysis
#7
Jose C Aldana-Aguirre, Merlin Pinto, Robin M Featherstone, Manoj Kumar
CONTEXT: In spontaneously breathing preterm infants with respiratory distress syndrome (RDS) receiving nasal continuous positive airway pressure, a method of less invasive surfactant administration (LISA) using a thin catheter has been described as an alternative to endotracheal intubation for surfactant delivery to reduce lung injury. OBJECTIVE: A systematic review of randomised controlled trials (RCTs) comparing LISA with the standard method of surfactant delivery for clinical outcomes...
November 15, 2016: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/27852166/perinatal-risk-factors-for-pneumothorax-and-morbidity-and-mortality-in-very-low-birth-weight-infants
#8
Fermín García-Muñoz Rodrigo, Lourdes Urquía Martí, Gloria Galán Henríquez, Sonia Rivero Rodríguez, Patricia Tejera Carreño, Silvia Molo Amorós, Pedro Cabrera Vega, Fernando Rodríguez Ramón
AIM: To determine the perinatal risk factors for pneumothorax in Very-Low-Birth-Weight (VLBW) infants and the associated morbidity and mortality in this population. METHODS: Retrospective analysis of data collected prospectively from a cohort of VLBW neonates assisted in our Unit (2006-2013). We included all consecutive in-born patients with? 1500 grams, without severe congenital anomalies. Perinatal history, demographics, interventions, and clinical outcomes were collected...
November 16, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27835691/surfactant-protein-a-and-b-gene-polymorphisms-and-risk-of-respiratory-distress-syndrome-in-late-preterm-neonates
#9
Maria-Eleni I Tsitoura, Eleana F Stavrou, Ioannis A Maraziotis, Kosmas Sarafidis, Aglaia Athanassiadou, Gabriel Dimitriou
BACKGROUND AND OBJECTIVES: Newborns delivered late-preterm (between 340/7 and 366/7 weeks of gestation) are at increased risk of respiratory distress syndrome (RDS). Polymorphisms within the surfactant protein (SP) A and B gene have been shown to predispose to RDS in preterm neonates. The aim of this study was to investigate whether specific SP-A and/or SP-B genetic variants are also associated with RDS in infants born late-preterm. METHODS: This prospective cross-sectional study included 56 late-preterm infants with and 60 without RDS...
2016: PloS One
https://www.readbyqxmd.com/read/27834786/use-of-naloxone-to-minimize-extubation-failure-after-premedication-for-insure-procedure-in-preterm-neonates
#10
A Elmekkawi, D Abdelgadir, J Van Dyk, J Choudhury, M Dunn
OBJECTIVES: A new guideline for the early respiratory management of preterm infants was recently introduced in our NICU. This case series describes the clinical courses of a group of preterm infants managed according to this guideline, and reports the rates of successful extubation within 30 minutes of surfactant administration with and without the use of naloxone and adverse events encountered. STUDY DESIGN: Descriptive case series of all preterm babies admitted to our unit who were candidates for INSURE procedure with premedication from August 2012 to August 2013...
November 9, 2016: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/27834149/development-and-evaluation-of-high-bioavailable-sustained-release-nimodipine-tablets-prepared-with-monolithic-osmotic-pump-technology
#11
Hua Kong, Fanglin Yu, Yan Liu, Yangyang, Mingyuan Li, Xiaohui Cheng, Xiaoqin Hu, Xuemei Tang, Zhiping Li, Xingguo Mei
BACKGROUND: Frequent administration caused by short half-life and low bioavailability due to poor solubility and low dissolution rate limit the further application of poorly water-soluble nimodipine although several new indications have been developed. To overcome these shortcomings, sophisticated technologies had to be used since the dose of nimodipine is not too low and the addition of solubilizers couldn't resolve the problem of poor release. OBJECTIVE: The purpose of this study was to obtain sustained and complete release of nimodipine with a simple and easily industrialized technology...
November 9, 2016: Current Drug Delivery
https://www.readbyqxmd.com/read/27826851/recombinant-activated-factor-viia-rfviia-treatment-in-very-low-birth-weight-vlbw-premature-infants-with-acute-pulmonary-hemorrhage-a-single-center-retrospective-study
#12
Hese Cosar, Halil Isik, Salih Cagrı Cakır, Nese Yar, Bulent Goksen, Hakan Tokbay, Hasan Kertmen, Nihal Erdoğan, Ikbal Durak
AIM: We aimed to evaluate the efficacy of intravenous administration of recombinant activated factor VIIa (rFVIIa) for acute pulmonary hemorrhage treatment in very-low-birth-weight (VLBW) premature infants. PATIENTS AND METHODS: This study was carried out retrospectively in premature infants with pulmonary hemorrhage that were ≤30 weeks gestational age or <1250 g birth weight. The data of all VLBW premature infants with pulmonary hemorrhage who were hospitalized in our neonatal intensive care unit between 01 January 2013 and 31 December 2015 were evaluated...
November 8, 2016: Paediatric Drugs
https://www.readbyqxmd.com/read/27812915/development-of-self-nanoemulsifying-drug-delivery-system-for-oral-bioavailability-enhancement-of-valsartan-in-beagle-dogs
#13
Zhenbao Li, Wenjuan Zhang, Yan Gao, Rongwu Xiang, Yan Liu, Mingming Hu, Mei Zhou, Xiaohong Liu, Yongjun Wang, Zhonggui He, Yinghua Sun, Jin Sun
Valsartan, an angiotensin II receptor antagonist, is widely used to treat high blood pressure in the clinical setting. However, its poor water solubility results in the low oral bioavailability. The aim of this study was to improve dissolution rate and oral bioavailability by developing a self-nanoemulsifying drug delivery system. Saturation solubility of valsartan in various oils, surfactants, and cosurfactants was investigated, and the optimized formulation was determined by central composite design-response surface methodology...
November 3, 2016: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/27799037/challenges-and-future-prospects-of-nanoemulsion-as-a-drug-delivery-system
#14
Megumi Nishitani Yukuyama, Edna Tomiko Myiake Kato, Raimar Löbenberg, Nadia Araci Bou-Chacra
Nanoemulsion has the potential to overcome several disadvantages in drug formulation. Loading poor water-soluble drugs in the appropriate nanoemulsions enhances their wettability and/or solubility. Consequently, this improves their pharmacokinetics and pharmacodynamics by different routes of administration. Associated with the optimum nanodroplets size or even combined with key components, the droplets act as a reservoir of drugs, enabling nanoemulsion to be multifunctional platform to treat diverse diseases...
October 27, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27792193/tocotrienol-nanoemulsion-platform-of-curcumin-elicit-elevated-apoptosis-and-augmentation-of-anticancer-efficacy-against-breast-and-ovarian-carcinomas
#15
Nelson Steuber, Kathy Vo, Ritambhara Wadhwa, Jordan Birch, Paulina Iacoban, Pedro Chavez, Tamer A Elbayoumi
Vitamin E (VE) tocotrienols (T3), recognized for their cancer-specific anti-proliferative and pro-apoptotic activities, have been previously fabricated into bio-active nanoemulsion (NE) formulations. Here, our viscosity-adapted δ-T3 NE platform was developed to additionally incorporate curcumin (CUR), which is known for its potent suppression of signaling pathways involved in malignant cell growth, survival and metastasis. Thanks to efficient 70:30 wt % surfactant mix of Lutrol F-127:VE-TPGS, in conjunction with optimal CUR loading, a prototype CUR in δ-T3 NE was successfully prepared...
October 26, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27788524/insufficient-sedation-and-severe-side-effects-after-fast-administration-of-remifentanil-during-insure-in-preterm-newborns
#16
Ellen H M de Kort, Lidwien M Hanff, Daniella Roofthooft, Irwin K M Reiss, Sinno H P Simons
BACKGROUND: Neonatal intubation is stressful and should be performed with premedication. In the case of an INSURE (intubation/surfactant/extubation) procedure a short duration of action of the premedication used is needed to facilitate fast extubation. Given its pharmacological profile, remifentanil seems a suitable candidate. OBJECTIVES: The aim here was to evaluate the effect and side effects of remifentanil as a premedication for preterm neonates undergoing INSURE...
October 28, 2016: Neonatology
https://www.readbyqxmd.com/read/27726904/nonylphenol-reduces-sperm-viability-and-fertility-of-mature-male-breeders-in-brown-tsaiya-ducks-anas-platyrhynchos
#17
Min-Chien Cheng, Hsin-I Chiang, Jiunn-Wang Liao, Che-Ming Hung, Ming-Yang Tsai, Yu-Hsin Chen, Jyh-Cherng Ju, Mei-Ping Cheng, Ko-Hua Tso, Yang-Kwang Fan
The aim of this study was to investigate the effect of nonylphenol (NP), a widely used surfactant, on the reproductive performance of male Brown Tsaiya ducks (Anas platyrhynchos) (MBBTDs). Mature MBBTDs (n=100) were treated with NP by daily gavaging of 0, 1 (NP1), 10 (NP10) and 250 (NP250) mg/kg-BW/d for 14 wk. Semen quality, fertilization rate and specific factors in blood plasma were measured. Weights of organs were also measured at 14 wk after NP administration. Ducks from each treatment (n=4) were continually treated with NP thereafter for 12 mo to observe changes of tissue ultrastructure by microscopic examination...
September 27, 2016: Animal Reproduction Science
https://www.readbyqxmd.com/read/27706130/evolution-of-surfactant-therapy-for-respiratory-distress-syndrome-past-present-and-future
#18
Smeeta Sardesai, Manoj Biniwale, Fiona Wertheimer, Arlene Garingo, Rangasamy Ramanathan
Respiratory distress syndrome (RDS) due to surfactant deficiency is the most common cause of respiratory failure in preterm infants. Tremendous progress has been made since the original description that surfactant deficiency is the major cause of RDS. Surfactant therapy has been extensively studied in preterm infants and has been shown to significantly decrease air leaks and neonatal and infant mortality. Synthetic and animal-derived surfactants from bovine as well as porcine origin have been evaluated in randomized controlled trials...
October 5, 2016: Pediatric Research
https://www.readbyqxmd.com/read/27697037/physicochemical-pharmacodynamic-and-pharmacokinetic-characterization-of-soluplus-stabilized-nanosuspension-of-tacrolimus
#19
Jaleh Varshosaz, Mohsen Minayian, Shila Yazdekhasti
Tacrolimus, an immunosuppressive drug has a variable pharmacokinetic and poor oral bioavailability due to poor solubility. The aim of the present study was enhancing the solubility and oral bioavailability of this drug. Tacrolimus nanoparticles were prepared by precipitation anti-solvent evaporation method. The effect of different parameters including: surfactant type, solvent to nonsolvent ratio and drug to surfactant ratio were studied on the particle size, saturated solubility and dissolution rate of the drug...
October 3, 2016: Current Drug Delivery
https://www.readbyqxmd.com/read/27693298/preparation-characterization-and-in-vivo-evaluation-of-microemulsions-containing-tamoxifen-citrate-anti-cancer-drug
#20
Faranak Dehghani, Nafiseh Farhadian, Shiva Golmohammadzadeh, Amir Biriaee, Mahmoud Ebrahimi, Mohammad Karimi
The aim of this study was to prepare and characterize a new nanocarrier for oral delivery of tamoxifen citrate (TMC) as a lipophilic oral administrated drug. This drug has low oral bioavailability due to its low aqueous solubility. To enhance the solubility of this drug, the microemulsion system was applied in form of oil-in-water. Sesame oil and Tween 80 were used as drug solvent oil and surfactant, respectively. Two different formulations were prepared for this purpose. The first formulation contained edible glycerin as co-surfactant and the second formulation contained Span 80 as a mixed surfactant...
September 27, 2016: European Journal of Pharmaceutical Sciences
keyword
keyword
41204
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"