Daniëlle C Voshart, Takuya Oshima, Yuting Jiang, Gideon P van der Linden, Anna P Ainslie, Luiza Reali Nazario, Fleur van Buuren-Broek, Ayla C Scholma, Hilmar R J van Weering, Nieske Brouwer, Jeffrey Sewdihal, Uilke Brouwer, Rob P Coppes, Inge R Holtman, Bart J L Eggen, Susanne M Kooistra, Lara Barazzuol
Over half of patients with brain tumors experience debilitating and often progressive cognitive decline after radiotherapy treatment. Microglia, the resident macrophages in the brain, have been implicated in this decline. In response to various insults, microglia can develop innate immune memory (IIM), which can either enhance (priming or training) or repress (tolerance) the response to subsequent inflammatory challenges. Here, we investigate whether radiation affects the IIM of microglia by irradiating the brains of rats and later exposing them to a secondary inflammatory stimulus...
February 14, 2024: Cell Reports