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https://www.readbyqxmd.com/read/28344823/forty-nine-years-in-biomaterials-science-an-interview-with-buddy-ratner
#1
Buddy Ratner
Buddy Ratner talks to Francesca Lake, Managing Editor. After receiving his PhD in polymer chemistry from the Polytechnic Institute of Brooklyn (USA) in 1972, Ratner moved to the University of Washington (USA), where he has since become joint professor of bioengineering and chemical engineering and Michael L & Myrna Darland Endowed Chair in Technology Commercialization. Since 1996, he has led the UWEB Research Center for Biomaterials at the University of Washington, originally funded by the National Science Foundation...
March 2017: Future Science OA
https://www.readbyqxmd.com/read/28342177/career-development-awards-in-emergency-medicine-resources-and-challenges
#2
Bryn E Mumma, Anna Marie Chang, Bory Kea, Megan L Ranney
OBJECTIVES: In the United States, emergency medicine researchers hold proportionately fewer federal career development awards than researchers in other specialties. Others hypothesize this deficit may partly be attributed to lack of mentors, departmental resources, and qualified applicants. Our objectives were to examine the association between departmental and institutional resources and career development awards and to describe the barriers to conducting research and obtaining grants in emergency medicine...
March 25, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28338349/clinical-features-of-children-and-adults-with-a-muscular-dystrophy-using-powered-indoor-outdoor-wheelchairs-disease-features-comorbidities-and-complications-of-disability
#3
Andrew Oliver Frank, Lorraine H De Souza
PURPOSE: To describe the clinical features of electric powered indoor/outdoor wheelchair users with a muscular dystrophy, likely to influence optimal prescription; reflecting features of muscular dystrophies, conditions secondary to disability, and comorbidities impacting on equipment provision. METHODS: Cross-sectional retrospective case note review of recipients of electric powered indoor/outdoor wheelchairs provided by a specialist regional wheelchair service...
February 25, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28336296/serotonin-and-dopamine-transporter-pet-changes-in-the-premotor-phase-of-lrrk2-parkinsonism-cross-sectional-studies
#4
Daryl J Wile, Pankaj A Agarwal, Michael Schulzer, Edwin Mak, Katherine Dinelle, Elham Shahinfard, Nasim Vafai, Kazuko Hasegawa, Jing Zhang, Jessamyn McKenzie, Nicole Neilson, Audrey Strongosky, Ryan J Uitti, Mark Guttman, Cyrus P Zabetian, Yu-Shin Ding, Mike Adam, Jan Aasly, Zbigniew K Wszolek, Matthew Farrer, Vesna Sossi, A Jon Stoessl
BACKGROUND: People with Parkinson's disease can show premotor neurochemical changes in the dopaminergic and non-dopaminergic systems. Using PET, we assessed whether dopaminergic and serotonin transporter changes are similar in LRRK2 mutation carriers with Parkinson's disease and individuals with sporadic Parkinson's disease, and whether LRRK2 mutation carriers without motor symptoms show PET changes. METHODS: We did two cross-sectional PET studies at the Pacific Parkinson's Research Centre in Vancouver, BC, Canada...
March 20, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28333418/annual-surveys-association-of-chairs-of-departments-of-physiology-2015-survey-results
#5
Elsa I Mangiarua, Melinda E Lowy, T Richard Nichols
No abstract text is available yet for this article.
July 2016: Physiologist
https://www.readbyqxmd.com/read/28330961/reference-values-for-developing-responsive-functional-outcome-measures-across-the-lifespan
#6
Marnee J McKay, Jennifer N Baldwin, Paulo Ferreira, Milena Simic, Natalie Vanicek, Joshua Burns
OBJECTIVE: To generate a reference dataset of commonly performed functional outcome measures in 1,000 children and adults and investigate the influence of demographic, anthropometric, strength, and flexibility characteristics. METHODS: Twelve functional outcome measures were collected from 1,000 healthy individuals aged 3-101 years: 6-minute walk test, 30-second chair stand test, timed stairs test, long jump, vertical jump, choice stepping reaction time, balance (Star Excursion Balance Test, tandem stance eyes open and closed, single-leg stance eyes closed), and dexterity (9-hole peg test, Functional Dexterity Test)...
March 22, 2017: Neurology
https://www.readbyqxmd.com/read/28326969/a-note-from-alexander-reiter-chair-of-the-nomenclature-committee
#7
Alexander M Reiter
No abstract text is available yet for this article.
June 2016: Journal of Veterinary Dentistry
https://www.readbyqxmd.com/read/28326723/-current-dental-implant-design-and-its-clinical-importance
#8
Lin Ye
The development of clinical implant dentistry was intensively affected by dental implant design improvement and innovation, which brought about new concept, even milestone-like changes of clinical protocol. The current improvements of dental implant design and their clinical importance could be highlighted as followings: 1) The implant apical design influences the implant preliminary stability in immediate implant. The apical 3-5 mm design of implant makes implant stable in immediate implant, because this part would be screwed into alveolar bone through fresh socket, the other part of implant could not be tightly screwed in the socket because of smaller implant diameter...
February 1, 2017: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28325824/persistence-of-myopathy-in-cushing-s-syndrome-evaluation-of-the-german-cushing-s-registry
#9
Christina Maria Berr, Mareike R Stieg, Timo Deutschbein, Marcus Quinkler, Ralf Schmidmaier, Andrea Osswald, Nicole Reisch, Katrin Ritzel, Christina Dimopoulou, Julia Fazel, Stefanie Hahner, Gunter K Stalla, Felix Beuschlein, Martin Reincke
BACKGROUND: Cushing's syndrome (CS) is characterized by an excessive secretion of glucocorticoids that results in a characteristic clinical phenotype. One feature of clinical hypercortisolism is breakdown of protein metabolism translating into clinical consequences including glucocorticoid induced myopathy. While surgery is effective in control of cortisol excess, the effect of biochemical remission on muscular function is yet unclear. METHODS: In a cross-sectional study we analyzed 47 patients with CS during the florid phase (ActiveCS)...
March 21, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28324960/design-and-characterization-of-a-torque-controllable-actuator-for-knee-assistance-during-sit-to-stand
#10
Max K Shepherd, Elliott J Rouse
Individuals with post-stroke hemiparesis often have difficulty standing out of a chair. One way to potentially improve sit-to-stand is to provide knee extension assistance using a powered knee exoskeleton. An exoskeleton providing unilateral, partial assistance during sit-to-stand would need to be torque-controllable. There are no knee exoskeletons on the market suitable for conducting experiments assisting stroke patients with sit-to-stand, so to enable such experiments a research device was developed. The purpose of this report is to present the design of a novel knee exoskeleton actuator that uses a fiberglass leaf spring in series to improve torque-controllability, and present a characterization of the actuator performance...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28324698/eye-stabilization-reflexes-in-traumatic-and-non-traumatic-chronic-neck-pain-patients
#11
Britta K Ischebeck, Jurryt de Vries, Malou Janssen, Jan Paul van Wingerden, Gert-Jan Kleinrensink, Jos N van der Geest, Maarten A Frens
BACKGROUND: Many chronic neck pain patients experience problems with vision. These problems are possibly induced by deviations of the eye stabilization reflexes. It is not known whether these eye reflex alterations occur both in traumatic and non-traumatic neck pain patients. OBJECTIVE: To investigate if the cervico-ocular reflex (COR) and the vestibulo-ocular reflex (VOR) are changed in tertiary care patients with prolonged, chronic neck pain with various origin of complaints...
March 16, 2017: Musculoskelet Sci Pract
https://www.readbyqxmd.com/read/28323136/self-reported-knee-pain-and-disability-among-healthy-individuals-reference-data-and-factors-associated-with-the-knee-injury-and-osteoarthritis-outcome-score-koos-and-koos-child
#12
Jennifer N Baldwin, Marnee J McKay, Claire E Hiller, Niamh Moloney, Elizabeth J Nightingale, Joshua Burns
OBJECTIVE: To develop normative reference data for the Knee injury and Osteoarthritis Outcome Score (KOOS) and KOOS-Child, as well as investigate socio-demographic, psychological and physical factors associated with knee pain and disability among healthy adults. METHOD: The KOOS or KOOS-Child (each containing five subscales) was administered to participants aged 8-101 years within the 1000 Norms Project, an observational study of 1000 self-reported healthy individuals...
March 16, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28322578/interview-with-amr-h-sawalha-epigenetics-and-autoimmunity
#13
Amr H Sawalha
Amr H Sawalha is Professor of Internal Medicine and Marvin and Betty Danto Research Professor of Connective Tissue Research at the University of Michigan, Department of Internal Medicine, Division of Rheumatology. He also holds faculty appointments at the Center for Computational Medicine and Bioinformatics and the Graduate Program in Immunology at the University of Michigan. He was recently appointed as Guest Professor at Central South University in Changsha, China. He received his medical degree from Jordan University of Science and Technology and completed his residency training in internal medicine at the University of Oklahoma Health Sciences Center, and his fellowship in rheumatology at the University of Michigan...
March 21, 2017: Epigenomics
https://www.readbyqxmd.com/read/28321886/-inside-out-pegylation-of-bovine-%C3%AE-cross-linked-hemoglobin
#14
Kyle D Webster, Dana Dahhan, Abigail M Otto, Cheyanne L Frosti, William L Dean, Jonathan B Chaires, Kenneth W Olsen
The development of a blood substitute is urgent due to blood shortages and potential communicable diseases. A novel method, inside-out PEGylation, has been used here to conjugate a multiarm maleimide-PEG (Mal-PEG) to β-cross-linked (βXL-Hb) hemoglobin (Hb) tetramers through the Cys β93 residues. This method produces a polymer with a single PEG backbone that is surrounded by multiple proteins, rather than coating a single protein with multiple PEG chains. Electrophoresis under denaturing conditions showed a large molecular weight species...
March 20, 2017: Artificial Organs
https://www.readbyqxmd.com/read/28320574/standardized-method-to-measure-muscle-force-at-the-bedside-in-hemodialysis-patients
#15
Jean-Sébastien Souweine, Agathe Boudet, Leila Chenine, Helene Leray, Annie Rodriguez, Georges Mourad, Jacques Mercier, Jean-Paul Cristol, Maurice Hayot, Fares Gouzi
OBJECTIVES: In hemodialysis, diminution of muscle strength constitutes a major prognostic factor of mortality. Currently, measurement of quadriceps isometric maximal voluntary force (MVF) represents the reference method to investigate muscle strength. However, reduction of MVF is rarely detected in these patients due to the absence of portative bedside tools in clinical practice. The purposes of this study were therefore to assess the agreement of a belt-stabilized handheld dynamometer (HHD) with the dynamometer chair (reference method) and to determine intratester and intertester reliability of the quadriceps MVF measurements using belt-stabilized HHD in healthy subjects and in hemodialysis patients...
March 17, 2017: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/28316830/crystal-structure-of-a-photobiologically-active-brominated-angular-pyran-ocoumarin-bromo-hy-droxy-seselin
#16
A K Bauri, Sabine Foro, A F M Mustafizur Rahman
The title compound, C14H13BrO3 [systematic name: rac-(9S,10R)-9-bromo-10-hy-droxy-8,8-dimethyl-9,10-di-hydro-2H,8H-pyrano[2,3-f]chromen-2-one], is a substituted pyran-ocoumarin, obtained by bromination of seselin [8,8-dimethyl-2H,8H-pyrano[2,3-f]chromen-2-one], which was isolated from the Indian herb Trachyspermum stictocarpum (Aajmod). The pyrano ring has a distorted half-chair conformation and its mean plane is inclined to the coumarin mean plane by 1.6 (2)°. In the crystal, mol-ecules are linked by pairs of O-H⋯O hydrogen bonds, forming inversion dimers with an R(2)2(16) ring motif...
March 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/28316816/crystal-structure-of-9-20-dimethyl-1-8-12-19-tetra-aza-tetra-cyclo-17-3-1-0-2-7-0-13-18-tricosane-dihydrate-from-synchrotron-x-ray-data
#17
Dohyun Moon, Jong-Ha Choi
The structure of the title compound, C21H40N4·2H2O, has been determined from synchrotron X-ray radiation data. The asymmetric unit comprises one 12-membered macropolycycle and two lattice water mol-ecules. The macropolycycle contains two cyclo-hexane rings and one 1,3-di-aza-cyclo-hexane ring, all in chair conformations. The C-N and C-C bond lengths are in the ranges 1.4526 (16)-1.4786 (17) and 1.517 (2)-1.5414 (17) Å, respectively. One intra-molecular N-H⋯N hydrogen bond helps to stabilize the mol-ecular conformation while medium-strength inter-molecular N-H⋯O, O-H⋯N and O-H⋯O hydrogen bonds involving the lattice water mol-ecules connect the components into a three-dimensional network...
March 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/28316803/ring-expansion-synthesis-and-crystal-structure-of-dimethyl-4-ethyl-1-4-5-6-7-8-hexa-hydro-azonino-5-6-b-indole-2-3-di-carboxyl-ate
#18
Van Tuyen Nguyen, Elena A Sorokina, Anna V Listratova, Leonid G Voskressensky, Nikolai N Lobanov, Pavel V Dorovatovskii, Yan V Zubavichus, Victor N Khrustalev
The title compound, C20H24N2O4, is the product of a ring-expansion reaction from a seven-membered hexa-hydro-azepine to a nine-membered azonine. The azonine ring of the mol-ecule adopts a chair-boat conformation. In the crystal, mol-ecules are linked by bifurcated N-H⋯(O,O) hydrogen bonds, generating [010] zigzag chains. The title compound shows inhibitory activity against acetyl-cholinesterase and butyrylcholinesterase, and might be considered as a candidate for the design of new types of anti-Alzheimer's drugs...
March 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/28316041/the-structure-of-cu-ii-and-hg-ii-complexes-of-bispyrenyl-azine-revisited
#19
Arturo Espinosa Ferao, Rafaela García
Azine ligands show preference for the antiperiplanar conformation, but their 2:2 ligand-metal complexes can exhibit a central N4M2 core in the most stable chair arrangement, as in the case of the model lithium complex, with the ligand displaying a synclinal conformation that is not stable in the free ligand. According to DFT calculations, complexation of Cu(2+) with bis(1-pyrenyl)azine (1) affords a C2-symmetric [1·Cu(2+)]2 species with a planar central N4Cu2 core exhibiting a weak cuprophilic interaction...
April 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28315537/acuity-based-scheduling-outcomes-in-ambulatory-oncology-centers
#20
LaCrista Edwards, Kimberly Hermis, Christopher R LeGette, Lourdes A Lujan, Cicely Scarlett
With an increase in the number of patients with cancer receiving treatment in the ambulatory setting, a need exists to evaluate lean approaches to provide safe, effective, and timely care delivery. Acuity-based scheduling (ABS) was implemented across the regional ambulatory care centers of a National Cancer Institute-designated comprehensive cancer center. ABS involved templates and a reconfiguration of clinical space and staff according to acuity levels. Results suggest improvement in wait times, capacity, infusion hours, chair use rate, patient visits, chair turns, average infusion length, and patient satisfaction...
April 1, 2017: Clinical Journal of Oncology Nursing
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