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https://www.readbyqxmd.com/read/29145286/bilateral-discoid-medial-meniscus-associated-with-meniscal-tears-and-hypoplasia-of-the-medial-femoral-condyle-a-case-report
#1
Hong-De Wang, Shi-Jun Gao
RATIONALE: Bilateral discoid medial menisci is an extremely rare abnormality of the knee joint. The presence of a discoid medial meniscus has been associated with magnetic resonance imaging (MRI) and radiographic changes in the tibial region, such as cupping of the medial tibial plateau and tibial physis collapse. While discoid medial meniscal tears with hypoplasia of the femoral medial condyles have not been previously reported. Herein, we report a case of bilateral discoid medial menisci associated with meniscal tears and femoral bone changes...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29129414/-surgical-management-of-deep-infiltrating-endometriosis-with-bowel-involvement-and-urinary-tract-involvement
#2
Sofiane Bendifallah, Marcos Ballester, Emile Darai
Endometriosis is a benign pathology that affects 3% of the general population and about 10% of women of reproductive age. Three anatomoclinical entities are described: peritoneal, ovarian (endometrioma) and deep endometriosis characterized by the infiltration of anatomical structures or organs beyond the peritoneum. Laparoscopic surgery should be performed, as this is associated with a reduction in postoperative complications, length of hospitalization and convalescence. Several surgical techniques allow the removal of deep endometriosis with colorectal involvement: rectal shaving, anterior discoid resection, segmental resection...
November 9, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/29123151/polymer-nanodiscs-discoidal-amphiphilic-block-copolymer-membranes-as-a-new-platform-for-membrane-proteins
#3
Mariana C Fiori, Yunjiang Jiang, Wan Zheng, Miguel Anzaldua, Mario J Borgnia, Guillermo A Altenberg, Hongjun Liang
Lipid nanodiscs are playing increasingly important roles in studies of the structure and function of membrane proteins. Development of lipid nanodiscs as a membrane-protein-supporting platform, or a drug targeting and delivery vehicle in general, is undermined by the fluidic and labile nature of lipid bilayers. Here, we report the discovery of polymer nanodiscs, i.e., discoidal amphiphilic block copolymer membrane patches encased within membrane scaffold proteins, as a novel two-dimensional nanomembrane that maintains the advantages of lipid nanodiscs while addressing their weaknesses...
November 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29122902/a-rare-case-of-unilateral-discoid-lupus-erythematosus-mimicking-lupus-vulgaris
#4
Parul Verma, Sucheta Pathania, Asha Kubba
Discoidlupus erythematosus (DLE) is a chronic type of cutaneous lupus erythematosus which can present in various morphologies, and the diagnosis can be rather confounding. Prompt evaluation and treatment is necessary to prevent disfigurement and systemic involvement associated with DLE. The following case presented a diagnostic dilemma as the lesion mimicked lupus vulgaris.
November 8, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29116115/characterization-of-apoj-reconstituted-high-density-lipoprotein-rhdl-nanodisc-for-the-potential-treatment-of-cerebral-%C3%AE-amyloidosis
#5
Sofía Fernández-de-Retana, Mary Cano-Sarabia, Paula Marazuela, Jose Luis Sánchez-Quesada, Annabel Garcia-Leon, Alex Montañola, Joan Montaner, Daniel Maspoch, Mar Hernández-Guillamon
Cerebral β-amyloidosis is a major feature of Alzheimer's disease (AD), characterized by the accumulation of β-amyloid protein (Aβ) in the brain. Several studies have implicated lipid/lipoprotein metabolism in the regulation of β-amyloidosis. In this regard, HDL (High Density Lipoprotein)-based therapies could ameliorate pathological features associated with AD. As apolipoprotein J (ApoJ) is a natural chaperone that interacts with Aβ, avoiding its aggregation and toxicity, in this study we propose to prepare reconstituted rHDL-rApoJ nanoparticles by assembling phospholipids with recombinant human ApoJ (rApoJ)...
November 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29115062/monogenic-interferonopathies-phenotypic-and-genotypic-findings-of-candle-syndrome-and-its-overlap-with-c1q-deficient-sle
#6
Sulaiman M Al-Mayouf, Alhanouf AlSaleem, Nora AlMutairi, Abdullah AlSonbul, Tariq Alzaid, Anas M Alazami, Hamoud Al-Mousa
OBJECTIVE: To report the clinical and genetic features of the first cases of chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) syndrome in an Arab population and to compare them with patients of C1q deficient systemic lupus erythematosus (SLE). MATERIALS AND METHODS: This is a retrospective case series of patients with CANDLE syndrome and C1q deficient SLE seen at a single tertiary hospital. Medical records were reviewed for demographic data, clinical and laboratory features, histopathology and imaging findings, and response to therapeutic intervention...
November 8, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29114641/transient-common-peroneal-and-tibial-nerve-palsy-following-knee-arthroscopy-for-the-treatment-of-discoid-lateral-meniscus
#7
Gabriele Bernardi, Cosimo Tudisco
The number of knee arthroscopies has increased rapidly since the 1980s and are among the most common orthopedic procedures today. It is generally considered a minimally invasive surgery with relatively low morbidity, but it is not without risk of complications. We report the case of a 14-year-old boy who developed a lesion of common peroneal nerve and tibial nerve after knee arthroscopy for a torn discoid lateral meniscus, which was confirmed by electromyogram study.
June 2017: Joints
https://www.readbyqxmd.com/read/29114640/evolution-of-osteochondritis-dissecans-of-the-lateral-femoral-condyle-combined-with-discoid-meniscus
#8
Erica Bulgheroni, Lorenzo Mattioli, Paolo Bulgheroni
The discoid meniscus is a rare anomaly of the knee that affects mostly the lateral meniscus and is often asymptomatic. The osteochondritis dissecans is a disorder of the subchondral bone and articular cartilage and occurs frequently associated with the discoid lateral meniscus. In the present case, we showed the evolution of this association related to surgical treatment. A patient with lateral knee pain and a magnetic resonance depicting a torn discoid lateral meniscus and osteochondritis dissecans of the lateral femoral condyle was treated with partial meniscectomy and meniscal sutures...
June 2017: Joints
https://www.readbyqxmd.com/read/29114168/a-new-species-of-pristimantis-from-eastern-brazilian-amazonia-anura-craugastoridae
#9
Elciomar Araújo De Oliveira, Luis Reginaldo Rodrigues, Igor Luis Kaefer, Karll Cavalcante Pinto, Emil José Hernández-Ruz
In this study a new species of Pristimantis (Anura: Craugastoridae) of the P. conspicillatus species group is described. Pristimantis latrosp. n. is known only from the municipalities of Altamira, Anapu, Brasil Novo, Medicilândia, Uruará and Aveiro (Flona Tapajós, right bank of Tapajós river), in Pará state, Brazil. Morphologically, the new species distinguishes from known congeners in the group mainly by the presence of dorsal tubercles and absence of discoidal folds, smooth belly skin, as well as the presence of supernumerary tubercles on hands...
2017: ZooKeys
https://www.readbyqxmd.com/read/29102423/rare-cause-of-periorbital-and-eyelids-lesions-discoid-lupus-erythematosus-misdiagnosed-as-allergy
#10
Anzelika Chomiciene, Ruta Stankeviciute, Laura Malinauskiene, Jurate Grigaitiene, Audra Blaziene
No abstract text is available yet for this article.
October 25, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29102413/posteriorly-inserted-anterior-cruciate-ligament-in-knees-with-discoid-lateral-meniscus-corresponding-to-bony-morphological-characteristics-of-femoral-lateral-condyle
#11
Takao Minami, Hideyuki Koga, Ichiro Sekiya, Toshifumi Watanabe, Masafumi Horie, Hiroki Katagiri, Koji Otabe, Toshiyuki Ohara, Mai Katakura, Takeshi Muneta
PURPOSE: Discoid meniscus often causes mechanical problems and needs surgical treatment at an early age. However, many aspects of its morphological development and changes remain unknown. The purpose of this study was to investigate the insertion of the femoral anterior cruciate ligament (ACL) via the behind-ACL approach and the morphology of the lateral femoral condyle to which the ACL attaches to clarify the morphological characteristics of the knee with discoid lateral meniscus (DLM)...
November 1, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/29097291/management-of-deep-infiltrating-endometriosis-of-the-rectum-is-a-systematic-temporary-stoma-relevant
#12
N Ledu, C Rubod, G Piessen, H Roman, P Collinet
STUDY OBJECTIVE: To assess the value of performing a protective stoma in patients operated for rectal endometriosis. MATERIAL AND METHODS: From June 2009 to December 2011, 47 patients were operated for rectal endometriosis by segmental or discoid resection in 4 different centers. Two groups were formed: one with protective stoma (group S), n=33 and one without protective stoma (group NS), n=14. Data were collected from the CIRENDO database. MEASUREMENTS AND MAIN RESULTS: Postoperative complication rate of group NS was 57% against 48% in group S (P=0...
October 31, 2017: Journal of gynecology obstetrics and human reproduction
https://www.readbyqxmd.com/read/29068087/dramatic-effect-of-hydroxychloroquine-on-lupus-alopecia
#13
Shohei Igari, Toshiyuki Yamamoto
Lupus alopecia is usually difficult to treat. We report a case of a 40-year-old woman with Sjögren's syndrome and atopic dermatitis who presented with discoid lupus erythematosus on the forearms and lupus erythematosus profundus with alopecia involving the scalp. A biopsy specimen taken from the discoid lupus erythematosus lesion on the forearm further exhibited a xanthomatous reaction, which however was not detected in another specimen from the lupus erythematosus profundus on the scalp. Treatment with oral hydroxychloroquine showed dramatic effects and complete hair regrowth was obtained 3 months later...
October 25, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/29059110/discoid-lateral-meniscus-in-children-diagnosis-management-and-outcomes
#14
Mininder S Kocher, Catherine A Logan, Dennis E Kramer
Discoid meniscus is a congenital variant of the knee joint that typically involves abnormal morphology and potential instability of the lateral meniscus. Some discoid menisci have abnormal peripheral attachments and are unstable. Discoid menisci are prone to tearing secondary to increased thickness, poor tissue quality, and instability. Patients may or may not be symptomatic. Torn or unstable discoid menisci cause mechanical symptoms, pain, and swelling. Symptomatic patients in whom nonsurgical management fails most frequently are treated with arthroscopic surgery...
November 2017: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/29050884/initial-digital-vasculitis-in-a-large-multicenter-cohort-of-childhood-onset-systemic-lupus-erythematosus
#15
Ana Paula Sakamoto, Clovis Artur Silva, Marco Felipe Castro da Silva, Anandreia Simões Lopes, Gleice Clemente Souza Russo, Adriana Maluf Elias Sallum, Katia Kozu, Eloisa Bonfá, Claudia Saad-Magalhães, Rosa Maria Rodrigues Pereira, Claudio Arnaldo Len, Maria Teresa Terreri
OBJECTIVES: To assess clinical digital vasculitis (DV) as an initial manifestation of childhood-onset systemic lupus erythematosus (cSLE) within a large population. METHODS: Multicenter cross-sectional study including 852 cSLE patients (ACR criteria) followed in ten Pediatric Rheumatology centers in São Paulo State, Brazil. RESULTS: DV was observed in 25/852 (3%) cSLE patients. Periungual hemorrhage was diagnosed in 12 (48%), periungual infarction in 7 (28%), tip finger ulceration in 4 (16%), painful nodules in 1 (4%) and gangrene in 1 (4%)...
October 16, 2017: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/29038195/discoid-lupus-erythematosus-when-a-superficial-injury-is-a-red-herring-of-underlying-disease
#16
Emily Senderey, Shamik Patel
No abstract text is available yet for this article.
October 15, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29030428/a-retractable-lid-in-lecithin-cholesterol-acyltransferase-provides-a-structural-mechanism-for-activation-by-apolipoprotein-a-i
#17
Kelly A Manthei, Joomi Ahn, Alisa Glukhova, Wenmin Yuan, Christopher Larkin, Taylor D Manett, Louise Chang, James A Shayman, Milton J Axley, Anna Schwendeman, John J G Tesmer
Lecithin:cholesterol acyltransferase (LCAT) plays a key role in reverse cholesterol transport by transferring an acyl group from phosphatidylcholine to cholesterol, promoting the maturation of high density lipoproteins (HDL) from discoidal to spherical particles. LCAT is activated through an unknown mechanism by apolipoprotein A-I (ApoA-I) and other mimetic peptides that form a belt around HDL. Here we report the crystal structure of LCAT with an extended lid that blocks access to the active site, consistent with an inactive conformation...
October 13, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29019745/imaging-of-nonmalignant-adrenal-lesions-in-children
#18
Kiran M Sargar, Geetika Khanna, Rebecca Hulett Bowling
The adrenal glands in children can be affected by a variety of benign lesions. The diagnosis of adrenal lesions can be challenging, but assessment of morphologic changes in correlation with the clinical presentation can lead to an accurate diagnosis. These lesions can be classified by their cause: congenital (eg, discoid adrenal gland, horseshoe adrenal gland, and epithelial cysts), vascular and/or traumatic (eg, adrenal hemorrhage), infectious (eg, granulomatous diseases), enzyme deficiency disorders (eg, congenital adrenal hyperplasia [CAH] and Wolman disease), benign neoplasms (eg, pheochromocytomas, ganglioneuromas, adrenal adenomas, and myelolipomas), and adrenal mass mimics (eg, extralobar sequestration and extramedullary hematopoiesis)...
October 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28993241/discoid-resection-of-rectosigmoid-endometriotic-nodules
#19
Mallory A Stuparich, Ted T M Lee
No abstract text is available yet for this article.
October 6, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28989792/how-tight-are-beetle-hugs-attachment-in-mating-leaf-beetles
#20
Dagmar Voigt, Alexey Tsipenyuk, Michael Varenberg
Similar to other leaf beetles, rosemary beetles Chrysolina americana exhibit a distinct sexual dimorphism in tarsal attachment setae. Setal discoid terminals occur only in males, and they have been previously associated with a long-term attachment to the female's back (elytra) during copulation and mate guarding. For the first time, we studied living males and females holding to female's elytra. Pull-off force measurements with a custom-made tribometer featuring a self-aligning sample holder confirmed stronger attachment to female elytra compared with glass in both males and females; corresponding to 45 and 30 times the body weight, respectively...
September 2017: Royal Society Open Science
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