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https://www.readbyqxmd.com/read/29341216/primary-scarring-alopecia-a-retrospective-study-of-89-patients-in-taiwan
#1
Hsing-Jou Su, An-Yu Cheng, Cheng-Han Liu, Chia-Bau Chu, Chaw-Ning Lee, Chao-Kai Hsu, Julia Yu-Yun Lee, Chao-Chun Yang
Primary scarring alopecia (PSA) is caused by irreversible damage to the hair epithelial stem cells that reside in hair follicles. There is limited published work regarding PSA amongst the Asian population. The aim of this study was to evaluate the clinical features and to characterize the subtypes of PSA in southern Taiwan. In this retrospective case series, we reviewed 89 patients with pathology-confirmed PSA. The data was collected from National Cheng Kung University Hospital between 1988 through 2016. The clinical and histological data were reviewed, and the patients were characterized into different subtypes of PSA based on the clinical features and histological findings...
January 16, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/29336019/computerized-planimetry-to-assess-clinical-responsiveness-in-a-phase-ii-randomized-trial-of-topical-r333-for-discoid-lupus-erythematosus
#2
J K Presto, L G Okon, R Feng, D J Wallace, R Furie, D Fiorentino, V P Werth
BACKGROUND: R333 is a topical janus kinase and spleen tyrosine kinase inhibitor being evaluated for discoid lupus erythematosus (DLE) treatment. There is no validated measure to assess area of active DLE lesions. OBJECTIVES: To evaluate R333 efficacy and assess a technique to measure responsiveness. METHODS: 54 DLE patients were randomized in a double blind design to R333 or placebo. The primary endpoint was the proportion of patients achieving ≥50% decrease in erythema and scale based on lesional CLASI for all treated lesions at week 4...
January 16, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29316339/reply-x-chromosome-short-arm-involvement-in-autoimmune-diseases-comment-on-the-report-by-sharma-et-al
#3
R Hal Scofield, Rohan Sharma, Valerie M Harris
Studying Klinefelter's syndrome (male 47,XXY) and triple X (female 4,7XXX), we propose that the number of X chromosomes mediates the female bias of systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS). Our recent paper described SLE and SS patients with extremely rare X chromosome aneuploides in which distal Xp was triplicated, implicating genes lying on the short arm of X1 . Brooks points out that X-linked chronic granulomatosus disease (X-CGD) can also have gene duplication from Xp21.2 to Xp terminus, and some female carriers of X-CDG have a cutaneous lupus-like illness...
January 5, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29310537/individuals-living-with-lupus-findings-from-the-lupus-uk-members-survey-2014
#4
C Morgan, A R Bland, C Maker, J Dunnage, I N Bruce
Systemic lupus erythematosus (SLE) is a complex and unpredictable disease which varies greatly among patients and has a significant impact on an individual's daily living and quality of life. A better understanding of the patients' experiences with the disease is vital to the effective management of the disease. LUPUS UK, a national UK-registered charity supporting people with systemic and discoid lupus, conducted a UK-wide survey of individuals living with lupus in order to provide foundation information to support and identify gaps needing further research...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29305617/decline-in-clinical-scores-at-long-term-follow-up-of-arthroscopically-treated-discoid-lateral-meniscus-in-children
#5
Jonathan D Haskel, Tyler J Uppstrom, David M Dare, Scott A Rodeo, Daniel W Green
PURPOSE: The purpose of this study was to examine the long-term clinical outcomes of arthroscopic partial meniscectomy for the treatment of discoid lateral meniscus in children. METHODS: A previous study identified 34 consecutive patients that underwent arthroscopic meniscal saucerization by one of the two surgeons between 1997 and 2002. Patients were asked to complete several outcomes questionnaires and were given the opportunity to receive a knee exam performed by their treating surgeon...
January 5, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29305383/is-abca1-a-lipid-transfer-protein
#6
Michael C Phillips
ATP-binding cassette transporter A1 (ABCA1) functions as a lipid transporter because it mediates the transfer of cellular phospholipid (PL) and free (unesterified) cholesterol (FC) to apolipoprotein (apo) A-I and related proteins present in the extracellular medium. ABCA1 is a membrane PL translocase and its enzymatic activity leads to transfer of PL molecules from the cytoplasmic leaflet to the exofacial leaflet of a cell plasma membrane. The presence of active ABCA1 in the plasma membrane promotes binding of apoA-I to the cell surface...
January 5, 2018: Journal of Lipid Research
https://www.readbyqxmd.com/read/29305289/prediction-models-to-improve-the-diagnostic-value-of-plain-radiographs-in-children-with-complete-discoid-lateral-meniscus
#7
Yong-Beom Park, Chul-Won Ha, Jae Won Jang, Manyoung Kim, Han-Jun Lee, Yong-Geun Park
PURPOSE: To develop prediction models to improve the diagnostic utility of plain radiographs for the diagnosis of complete discoid lateral meniscus by combining previously reported radiographic findings. METHODS: Patients ages 5 to 16 years with complete discoid lateral meniscus confirmed by arthroscopy or magnetic resonance imaging were included. Patients with insufficient radiographs were excluded. Normal control subjects were randomly sampled by age and sex matching...
January 2, 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29273236/effect-of-tooth-substrate-and-porcelain-thickness-on-porcelain-veneer-failure-loads-in-vitro
#8
Chunling Ge, Chad C Green, Dalene A Sederstrom, Edward A McLaren, James A Chalfant, Shane N White
STATEMENT OF PROBLEM: Bonded porcelain veneers are widely used esthetic restorations. High success and survival rates have been reported, but failures do occur. Fractures are the commonest failure mode. Minimally invasive or thin veneers have gained popularity. Increased enamel and porcelain thickness improve the strength of veneers bonded to enamel, but less is known about dentin or mixed substrates. PURPOSE: The purpose of this in vitro study was to measure the influences of tooth substrate type (all-enamel, all-dentin, or half-dentin-half-enamel) and veneer thickness on the loads needed to cause initial and catastrophic porcelain veneer failure...
December 19, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/29214102/white-rosettes-in-discoid-lupus-erythematosus-a-new-dermoscopic-observation
#9
Balachandra S Ankad, Swapnil D Shah, Keshavmurthy A Adya
White rosettes are shiny white structures seen as four oval-shaped points that come together in the center. They resemble four-leaf clover [1]. Earlier it was thought they were specific for actinic keratosis and squamous cell carcinoma, but they are noted in many other conditions [2]. With polarized light dermoscopy, it is evident that rosettes are seen only and they are due to the optical effect between polarized light and follicular structures [3]. Here, authors describe cases of discoid lupus erythematosus (DLE) demonstrating rosettes under polarized dermoscopy...
October 2017: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/29208698/arginine-123-of-apolipoprotein-a-i-is-essential-for-lecithin-cholesterol-acyltransferase-activity
#10
Irina N Gorshkova, Xiaohu Mei, David Atkinson
ApoA-I activates LCAT that converts lipoprotein cholesterol to cholesteryl ester (CE). Molecular dynamic simulations suggested earlier that helices 5 of two antiparallel apoA-I molecules on discoidal HDL form an amphipathic tunnel for migration of acyl chains and unesterified cholesterol to the active sites of LCAT. Our recent crystal structure of Δ(185-243)apoA-I showed the tunnel formed by helices 5/5, with two positively charged residues Arg123 positioned at the edge of the hydrophobic tunnel. We hypothesized that these uniquely positioned Arg123 are poised for interaction with fatty acids produced by LCAT hydrolysis of the sn2-chains of phosphatidylcholine thus positioning the fatty acids for esterification to cholesterol...
December 5, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/29188421/arthroscopic-partial-meniscectomy-in-young-patients-with-symptomatic-discoid-lateral-meniscus-an-average-10-year-follow-up-study
#11
Chang-Rack Lee, Seong-Il Bin, Jong-Min Kim, Bum-Sik Lee, Nam-Ki Kim
INTRODUCTION: The aim of this study is to evaluate mid-to-long-term clinical and radiological outcomes after an arthroscopic partial meniscectomy for symptomatic discoid lateral meniscus (DLM) in young patients and to determine whether degeneration of the residual meniscus and articular cartilage progresses during the follow-up period using magnetic resonance imaging (MRI). MATERIALS AND METHODS: We retrospectively reviewed patients aged ≤ 40 years at surgery who underwent arthroscopic partial meniscectomy for symptomatic DLM and were followed up for ≥ 5 years...
November 29, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29183885/can-we-predict-the-clinical-outcome-of-arthroscopic-partial-meniscectomy-a-systematic-review
#12
REVIEW
Susanne M Eijgenraam, Max Reijman, Sita M A Bierma-Zeinstra, Daan T van Yperen, Duncan E Meuffels
NHS-PROSPERO REGISTRATION NUMBER: 42016048592 OBJECTIVE: In order to make a more evidence-based selection of patients who would benefit the most from arthroscopic partial meniscectomy (APM), knowledge of prognostic factors is essential. We conducted a systematic review of predictors for the clinical outcome following APM. DESIGN: Systematic review DATA SOURCES: Medline, Embase, Cochrane Central Register, Web of Science, SPORTDiscus, PubMed Publisher, Google Scholar INCLUSION CRITERIA: Report an association between factor(s) and clinical outcome; validated questionnaire; follow-up >1 year...
November 28, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29183581/deciphering-the-toxic-effects-of-organochlorine-pesticide-dicofol-on-human-rbcs-and-lymphocytes
#13
Ajaz Ahmad, Masood Ahmad
Organochlorine pesticides have generated growing concern owing to their diverse toxicities. In this connection, we have evaluated toxic potential of an acaricide, dicofol (DCF) and its harmful effects on human RBCs and lymphocytes. DCF caused hemolysis and rupture of human erythrocytes as confirmed by scanning electron microscopy (SEM). Significant increase in protein oxidation, lipid peroxidation, ROS production, methemoglobin formation with enhanced activities of superoxide dismutase and catalase but decreased level of reduced glutathione were observed as a result of DCF exposure to human erythrocytes...
November 2017: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/29177151/blue-white-veil-as-novel-dermatoscopic-feature-in-discoid-lupus-erythematosus-in-2-african-american-patients
#14
Jessica Cervantes, Farhaan Hafeez, Mariya Miteva
Dermoscopic features of discoid lupus erythematosus (DLE) depend on the stage of the lesions: active lesions include yellow-brown dots and red dots, whereas longstanding inactive lesions show absence of follicular openings, cicatricial milky red or white patches, structureless white and brown areas, and thick arborizing vessels. Loss of pinpoint white dots, blue-gray dots in a speckled pattern, and a peripheral pigmented network have been described on dermoscopy of DLE in dark skin. We report a blue-white veil as a novel dermoscopic feature in 2 cases of biopsy-proven DLE in African-American patients...
October 2017: Skin Appendage Disorders
https://www.readbyqxmd.com/read/29167152/rab27b-requirement-for-stretch-induced-exocytosis-in-bladder-umbrella-cells
#15
Luciana I Gallo, Marianela G Dalghi, Dennis R Clayton, Wily G Ruiz, Puneet Khandelwal, Gerard Apodaca
Umbrella cells, which must maintain a tight barrier, modulate their apical surface area during bladder filling by exocytosis of an abundant, subapical pool of discoidal- and/or fusiform-shaped vesicles (DFVs). Despite the importance of this trafficking event for bladder function, the pathways the promote DFV exocytosis remain to be identified. We previously showed that DFV exocytosis depends in part on a RAB11A-RAB8A-MYO5B network, but RAB27B is also reported to be associated with DFVs, and knockout mice lacking RAB27B have fewer DFVs...
November 22, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/29166518/yellow-dots-in-trichoscopy-relevance-clinical-significance-and-peculiarities
#16
Caren Dos Santos Lima, Luciana Rodino Lemes, Daniel Fernandes Melo
Yellow dots are follicular ostium filled with keratin and/or sebum. Initially, they were exclusively associated with alopecia areata. Currently they have also been described in androgenetic alopecia, chronic cutaneous (discoid) lupus erythematosus, and dissecting cellulitis. Due to the growing importance of trichoscopy and its findings in the evaluation of the scalp, this article describes the main diseases in which yellow dots are a common trichoscopic finding, highlighting its characteristics in each dermatosis...
September 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29163489/ameliorating-amyloid-%C3%AE-fibrils-triggered-inflammation-via-curcumin-loaded-polymeric-nanoconstructs
#17
Andrea Ameruoso, Roberto Palomba, Anna Lisa Palange, Antonio Cervadoro, Aeju Lee, Daniele Di Mascolo, Paolo Decuzzi
Inflammation is a common hallmark in several diseases, including atherosclerosis, cancer, obesity, and neurodegeneration. In Alzheimer's disease (AD), growing evidence directly correlates neuronal damage with inflammation of myeloid brain cells, such as microglia. Here, polymeric nanoparticles were engineered and characterized for the delivery of anti-inflammatory molecules to macrophages stimulated via direct incubation with amyloid-β fibers. 200 nm spherical polymeric nanoconstructs (SPNs) and 1,000 nm discoidal polymeric nanoconstructs (DPNs) were synthesized using poly(lactic-co-glycolic acid) (PLGA), polyethylene glycol (PEG), and lipid chains as building blocks...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29145286/bilateral-discoid-medial-meniscus-associated-with-meniscal-tears-and-hypoplasia-of-the-medial-femoral-condyle-a-case-report
#18
Hong-De Wang, Shi-Jun Gao
RATIONALE: Bilateral discoid medial menisci is an extremely rare abnormality of the knee joint. The presence of a discoid medial meniscus has been associated with magnetic resonance imaging (MRI) and radiographic changes in the tibial region, such as cupping of the medial tibial plateau and tibial physis collapse. While discoid medial meniscal tears with hypoplasia of the femoral medial condyles have not been previously reported. Herein, we report a case of bilateral discoid medial menisci associated with meniscal tears and femoral bone changes...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29129414/-surgical-management-of-deep-infiltrating-endometriosis-with-bowel-involvement-and-urinary-tract-involvement
#19
Sofiane Bendifallah, Marcos Ballester, Emile Darai
Endometriosis is a benign pathology that affects 3% of the general population and about 10% of women of reproductive age. Three anatomoclinical entities are described: peritoneal, ovarian (endometrioma) and deep endometriosis characterized by the infiltration of anatomical structures or organs beyond the peritoneum. Laparoscopic surgery should be performed, as this is associated with a reduction in postoperative complications, length of hospitalization and convalescence. Several surgical techniques allow the removal of deep endometriosis with colorectal involvement: rectal shaving, anterior discoid resection, segmental resection...
November 9, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/29123151/polymer-nanodiscs-discoidal-amphiphilic-block-copolymer-membranes-as-a-new-platform-for-membrane-proteins
#20
Mariana C Fiori, Yunjiang Jiang, Wan Zheng, Miguel Anzaldua, Mario J Borgnia, Guillermo A Altenberg, Hongjun Liang
Lipid nanodiscs are playing increasingly important roles in studies of the structure and function of membrane proteins. Development of lipid nanodiscs as a membrane-protein-supporting platform, or a drug targeting and delivery vehicle in general, is undermined by the fluidic and labile nature of lipid bilayers. Here, we report the discovery of polymer nanodiscs, i.e., discoidal amphiphilic block copolymer membrane patches encased within membrane scaffold proteins, as a novel two-dimensional nanomembrane that maintains the advantages of lipid nanodiscs while addressing their weaknesses...
November 9, 2017: Scientific Reports
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