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https://www.readbyqxmd.com/read/28329473/successful-treatment-of-recalcitrant-discoid-lupus-erythematosus-with-ustekinumab
#1
Alberto Romero-Maté, Carmen García-Donoso, Almudena Hernández-Núñez, Cristina Martínez-Morán, Amalia Moreno-Torres, Jesús Borbujo-Martínez
We report a 52-year old woman with a 28-year historyof disfiguring facial discoid lupus erythematosus(DLE), persistent despite both classical therapiesand rituximab. Ustekinumab 45 mg was started incombination with methotrexate and intralesionalcorticosteroids. Methotrexate and intralesionalcorticosteroids were withdrawn 30 months later andustekinumab maintained as monotherapy. Fortyeight months later stable improvement was achievedwithout side effects. Only nine patients with cutaneouslupus erythematosus (CLE) treated with ustekinumabhave been reported to date...
January 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28323786/reply-to-direct-immunofluorescence-findings-in-discoid-lupus-erythematosus-and-bullous-pemphigoid
#2
Chika Ohata, Bungo Ohyama, Hiroshi Nagata, Minao Furumura, Takekuni Nakama
No abstract text is available yet for this article.
April 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28322362/immunopathogenic-oral-diseases-%C3%A2-an-overview-focusing-on-pemphigus-vulgaris-and-mucous-membrane-pemphigoid
#3
Liviu Feller, Raoul Ballyram, Razia Ag Khammissa, Mario Altini, Johan Lemmer
Pemphigus vulgaris, mucosal pemphigoid (mucous membrane pemphigoid), lichen planus, discoid lupus erythematosus and erythema multiforme are a group of immune-mediated mucocutaneous disorders characterised clinically by the formation of blisters, erosions or ulcers. The oral mucosa is often affected, and sometimes the disease is limited to the mouth. The target antigens, autoreactive immune responses, microscopic features, treatment and prognosis vary from one disease to the other. Treatment aims to eliminate exogenous risk factors, suppress the pathogenic immuno-inflammatory reactions, promote healing and prevent infection...
March 20, 2017: Oral Health & Preventive Dentistry
https://www.readbyqxmd.com/read/28301332/sculpturing-patterns-of-plasmonic-silver-nanoprisms-by-means-of-photocatalytic-lithography
#4
Guido Panzarasa, Guido Soliveri, Gianluigi Marra, Laura Meda, Alberto Savoini, Silvia Ardizzone, Mario Salvalaggio
The controlled shaping of nanoparticles' morphology is one of the pillars of nanotechnology. Here, we demonstrate that photocatalytic lithography, a technique already proved to be useful in materials science, can act as a dry etching technique for noble metal nanoparticles. Triangular silver nanoprisms are self-assembled on titanium dioxide films and photocatalytically shaped into discoidal particles upon irradiation with near-UV light. The obtained patterned surfaces show a dramatically different surface-enhanced Raman scattering response, suggesting the utility of our approach for the development of sensors...
April 18, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28300917/periorbital-discoid-lupus-a-rare-localization-in-a-patient-with-systemic-lupus-erythematosus
#5
Ozgur Cakici, Remzi Karadag, Huseyin Bayramlar, Seyma Ozkanli, Tugba Kevser Uzuncakmak, Ayse Serap Karadag
A 40-year-old female patient with a 5-year history of systemic lupus erythematosus was referred to our policlinic with complaints of erythema, atrophy, and telangiectasia on the upper eyelids for 8 months. No associated mucocutaneous lesion was present. Biopsy taken by our ophthalmology department revealed discoid lupus erythematosus. Topical tacrolimus was augmented to the systemic therapeutic regimen of the patient, which consisted of continuous antimalarial treatment and intermittent corticosteroid drugs...
September 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28300881/frontal-fibrosing-alopecia-in-association-with-sj%C3%A3-gren-s-syndrome-more-than-a-simple-coincidence
#6
Karina Colossi Furlan, Priscila Kakizaki, Juliana Cabral Nunes Chartuni, Neusa Yuriko Sakai Valente
Frontal fibrosing alopecia is a distinctive form of scarring alopecia considered to be a clinical variant of lichen planopilaris. It predominantly occurs in postmenopausal women and has a slowly progressive course. It was first described by Kossard in 1994. Since then the number of reported cases has increased significantly. Coexistence of frontal fibrosing alopecia and autoimmune disorders - such as discoid erythematosus lupus and Sjögren's syndrome - may suggest a common pathogenic background among the diseases...
September 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28276018/reconstitution-of-mitochondrial-membrane-proteins-into-nanodiscs-by-cell-free-expression
#7
Ketan Malhotra, Nathan N Alder
The isolation and characterization of mitochondrial membrane proteins is technically challenging because they natively reside within the specialized environment of the lipid bilayer, an environment that must be recapitulated to some degree during reconstitution to ensure proper folding, stability, and function. Here we describe protocols for the assembly of a membrane protein into lipid bilayer nanodiscs in a series of cell-free reactions. Cell-free expression of membrane proteins circumvents problems attendant with in vivo expression such as cytotoxicity, low expression levels, and the formation of inclusion bodies...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28272930/risk-factors-associated-with-knee-joint-degeneration-after-arthroscopic-reshaping-for-juvenile-discoid-lateral-meniscus
#8
Shinya Yamasaki, Yusuke Hashimoto, Junsei Takigami, Shozaburo Terai, Shinji Takahashi, Hiroaki Nakamura
BACKGROUND: Although arthroscopic meniscal reshaping for discoid lateral meniscus (DLM) has better outcomes than total or subtotal meniscectomy, degenerative changes on radiographs are still seen in some patients with meniscal reshaping. PURPOSE: To assess the risk factors associated with knee joint degeneration after reshaping surgery for juvenile DLM. STUDY DESIGN: Case-control study; Level of evidence, 3. METHODS: Forty patients (45 knees) with a mean age of 12...
March 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28258328/arthroscopic-meniscus-repair-for-recurrent-subluxation-of-the-lateral-meniscus
#9
Jin Hwan Ahn, Sang Hak Lee, Kang Il Kim, Juhyun Nam
PURPOSE: This study was undertaken to diagnose and to document the clinical results and technical aspects of arthroscopic meniscus repair for recurrent subluxation with peripheral tears around the popliteal hiatus of the lateral meniscus. METHODS: Twenty-three patients (24 knees) with symptomatic recurrent subluxation of the lateral meniscus treated by arthroscopic meniscus repair were included. The inclusion criteria were: (1) patients with knee pain, locking or snapping symptoms despite 3 months of conservative treatment; (2) non-discoid lateral meniscus; (3) stable knee, and (4) tears involving the red-white or red-red zone...
March 3, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28247256/-rare-cutaneous-tuberculosis-in-sub-saharan-africa-developed-on-discoid-lupus-erythematous-lesion
#10
A Diop, M T Ndiaye, M Ndiaye, B Seck, A Diouf, B H Diatta, M Diallo, F Ly
Lupus vulgaris is a common presentation of cutaneous tuberculosis (TB), but its ulcerative or vegetating form also called vorax is rare.We report a case of lupus vulgaris in its vorax form, which occurred in a patient with discoid lupus erythematous. A 42-year-old patient monitored for chronic lupus erythematosus consulted again for a facial tumor and fever. Physical examination revealed painful ulcerative and crusted lesions on an old discoid lupus lesion and covered the entire upper lip. Similar lesions were noted on cheeks...
February 28, 2017: Bulletin de la Société de Pathologie Exotique
https://www.readbyqxmd.com/read/28229984/anatomical-knee-variants-in-discoid-lateral-meniscal-tears
#11
Xu-Xu Chen, Jian Li, Tao Wang, Yang Zhao, Hui Kang
BACKGROUND: Discoid lateral meniscus was a common meniscal dysplasia and was predisposed to tear. There were some anatomical knee variants in patients with discoid lateral meniscus. The aim of this study was to analyze the relationship between anatomical knee variants and discoid lateral meniscal tears. METHODS: There were totally 125 cases of discoid lateral meniscus enrolled in this study from February 2008 to December 2013. Eighty-seven patients who underwent arthroscopic surgery for right torn discoid lateral meniscus were enrolled in the torn group...
2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28197693/predictive-factors-for-osteochondritis-dissecans-of-the-lateral-femoral-condyle-concurrent-with-a-discoid-lateral-meniscus
#12
Junsei Takigami, Yusuke Hashimoto, Tomohiro Tomihara, Shinya Yamasaki, Koji Tamai, Kyoko Kondo, Hiroaki Nakamura
PURPOSE: Osteochondritis dissecans (OCD) of the lateral femoral condyle is relatively rare, and it is often reported in combination with discoid lateral meniscus. However, little is known about the mechanism underlying this connection. Predictive factors for OCD coinciding with discoid lateral meniscus in Japanese children and adolescents were assessed. METHODS: During 2000-2015, 152 knees in 133 patients aged 5-15 years were diagnosed with symptomatic complete discoid lateral meniscus...
February 14, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28196317/common-skin-conditions-in-children-noninfectious-rashes
#13
Brian Z Rayala, Dean S Morrell
Cutaneous adverse drug reactions are among the most common noninfectious rashes of childhood. Cutaneous adverse drug reactions are classified as morbilliform, urticarial, bullous, pustular, or psoriasiform. Atopic dermatitis is one of the most common inflammatory cutaneous eruptions, and is characterized by pruritus and flexural distribution. Emollients and topical corticosteroids are first-line therapies. Topical calcineurin inhibitors are second-line, steroid-sparing drugs for certain conditions, such as face and eyelid eczema...
February 2017: FP Essentials
https://www.readbyqxmd.com/read/28194816/verrucous-discoid-lupus-erythematosus-in-a-child
#14
F Topaloglu Demir, F Deniz, Y Ozben, I Kivanc Altunay
No abstract text is available yet for this article.
February 13, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28184992/association-study-between-the-tp53-rs1042522g-c-polymorphism-and-susceptibility-to-systemic-lupus-erythematosus-in-a-chinese-han-population
#15
Jie Yang, Ji-Min Zhu, Song Wu, Jing Li, Ming-Rui Wang, Ting-Ting Wang, Yu-Wei Lu
Tumour suppressor protein 53 (p53) plays a central role in apoptosis, cell proliferation and death. Previously studies found contribution of functional p53 Arg72Pro polymorphism (TP53 rs1042522G/C polymorphism) in the development of systemic lupus erythematosus (SLE) remains controversial. In this study, for the first time, we evaluated its association with SLE in a Chinese Han population. This case-control study enrolled 1470 SLE patients and 2283 healthy controls. The genotyping of TP53 rs1042522 polymorphism was determined by Sequenom Mass ARRAY technology...
February 9, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28170256/self-assembling-and-luminescent-properties-of-chiral-bisoxadiazole-derivatives-in-solution-and-liquid-crystalline-phases
#16
Aneesh P Sivadas, D S Shankar Rao, N S Saleesh Kumar, Deepak D Prabhu, Shinto Varghese, C N Ramachandran, Rahul M Ongungal, S Krishna Prasad, Suresh Das
Herein, we report the synthesis, self-assembly, and electroluminescence characteristics of a new green-emitting, pseudodiscoid chiral molecule, OXDC, containing an electron-donating stilbene core and an electron-accepting oxadiazole substituent. The helical organization and specific interaction of the chiral pseudodiscoid molecule resulted in the formation of self-assembled nanofibers with a columnar superstructure. Macroscopic chirality was observed in both the liquid-crystalline phases and the self-assembled nanofibers of OXDC, a feature which was absent in the analogous achiral oxadiazole derivative reported earlier [ Sivadas , A...
February 21, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28164061/arthroscopic-meniscectomy-and-meniscoplasty-for-a-torn-discoid-medial-meniscus-case-report-surgical-technique-and-literature-review
#17
Gokhale Nikhil Abhay, Samant Ashwin, Shahane Sunil, Kapopara Hardik
INTRODUCTION: Normal menisci of the knee are semilunar structures. Sometimes, a meniscus may be found to be thickened and disc like and is called a discoid meniscus. Such a discoid variant is usually found in the lateral meniscus. Its occurrence in the medial meniscus is extremely rare. CASE REPORT: We report a case of an 18-year-old female, who presented to us with knee pain and was found to have a discoid medial meniscus with a tear. We operated on her arthroscopically and performed meniscectomy and meniscoplasty...
September 2016: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28164045/ipsilateral-medial-and-lateral-discoid-meniscus-with-medial-meniscus-tear
#18
Kengo Shimozaki, Junsuke Nakase, Yoshinori Ohashi, Hitoaki Numata, Takeshi Oshima, Yasushi Takata, Hiroyuki Tsuchiya
INTRODUCTION: Discoid meniscus is a well-documented knee pathology, and there are many cases of medial or lateral discoid meniscus reported in the literature. However, ipsilateral concurrent medial and lateral discoid meniscus is very rare, and only a few cases have been reported. Herein, we report a case of concurrent medial and lateral discoid meniscus. CASE REPORT: A 27-year-old Japanese man complained of pain on medial joint space in his right knee that was diagnosed as a complete medial and lateral discoid meniscus...
September 2016: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28160013/high-tibial-osteotomy-accelerates-lateral-compartment-osteoarthritis-in-discoid-meniscus-patients
#19
Jatin Prakash, Eun-Kyoo Song, Hong An Lim, Young Joo Shin, Cheng Jin, Jong-Keun Seon
PURPOSE: The valgus high tibial osteotomy (HTO) in patients with medial osteoarthritis and discoid lateral meniscus can result in increased load on the lateral compartment and hence a higher chances of tear. This may accelerate the progression of osteoarthritis on lateral compartment. We, therefore, carried out the case control study with a hypothesis that an HTO would accelerate the progression of osteoarthritis (OA) on lateral compartment in patients with complete discoid meniscus. METHODS: The records of all patients with open wedge HTO from 2008 to 2012 were evaluated for complete lateral discoid meniscus...
February 3, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28133824/a-retrospective-study-comparing-histopathological-and-immunopathological-features-of-nasal-planum-dermatitis-in-20-dogs-with-discoid-lupus-erythematosus-or-leishmaniosis
#20
Michela De Lucia, Giorgia Mezzalira, Mar Bardagí, Dolors M Fondevila, Elisabetta Fabbri, Alessandra Fondati
BACKGROUND: In areas endemic for leishmaniosis, discoid lupus erythematosus (DLE) and canine leishmaniosis (CanL) are the most common differential diagnoses for nasal planum erosive-ulcerative dermatitis in dogs. HYPOTHESIS/OBJECTIVE: To compare histopathological and immunopathological features of canine nasal planum erosive-ulcerative dermatitis with depigmentation due to DLE or CanL. ANIMALS: Nasal planum biopsies from dogs with nasal planum loss of architecture, depigmentation, swelling, erosions or ulcerations due to DLE (n = 14) or CanL (n = 6)...
January 29, 2017: Veterinary Dermatology
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