keyword
https://read.qxmd.com/read/38487125/a-case-report-unveiling-the-underlying-cause-of-recurrent-pericarditis-in-a-patient-with-undifferentiated-connective-tissue-disease
#1
Samantha Boever, Kareem Bannis
Undifferentiated connective tissue disease (UCTD) is a condition characterized by symptoms and laboratory findings related to various systematic autoimmune diseases. Severe symptoms like chest pain in patients with UCTD could suggest an underlying secondary condition, such as pericarditis. Our case involves a 36-year-old woman with a history of UCTD and recently diagnosed rheumatoid arthritis (RA) who presented with persistent sub-sternal chest pain and pressure that began three weeks ago. Over the past year, she experienced six similar episodes of chest pain, diagnosed as idiopathic pericarditis...
February 2024: Curēus
https://read.qxmd.com/read/38440016/a-case-of-hydroxychloroquine-toxicity-as-evidenced-by-visual-field-changes
#2
Aliya Centner, Donald J Centner
Hydroxychloroquine sulfate (Plaquenil®) is a disease-modifying anti-rheumatic drug (DMARD) utilized in the management of autoimmune diseases. While its immunomodulatory actions offer therapeutic benefits, a rare complication, hydroxychloroquine-induced retinal toxicity, poses a significant concern. We present the case of an 83-year-old patient with cutaneous lupus undergoing periodic hydroxychloroquine screening for eight years. Visual field changes consistent with retinal toxicity were observed. Chart review revealed subtle visual field depression two years prior...
February 2024: Curēus
https://read.qxmd.com/read/38375729/effect-of-pulse-methylprednisolone-on-prognosis-in-sars-cov-2-patients-with-severe-pneumonia
#3
JOURNAL ARTICLE
B Z Eraslan, A Fidan, T Baysal, S S Cömert, N Kıral, E T Parmaksız
OBJECTIVE: This study aimed to evaluate the effect of pulse methylprednisolone treatment on prognosis in severe COVID-19 pneumonia. PATIENTS AND METHODS: This retrospective cohort study included 128 patients hospitalized in our clinic for severe COVID-19 between March 2020 and February 2021. Standard treatment (plaquenil, favipravir, low molecular weight heparin, and antibiotics when necessary) was given to the patients in accordance with the Turkish Ministry of Health guidelines...
February 2024: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/37974912/autoimmune-related-retinopathy-presenting-as-plaquenil-toxicity-in-patients-with-systemic-lupus-erythematosus
#4
Justin P Ma, Kubra Sarici, Alessandro Iannaccone, Majda Hadziahmetovic
Purpose: To report 3 cases of autoimmune retinopathy (AIR) in patients with systemic lupus erythematosus (SLE) to explore the association between these conditions and highlight additional clinical consideration of AIR in patients presenting with atypical retinopathy in the context of hydroxychloroquine use. Methods: The medical and clinical follow-up records of 3 clinical cases were reviewed. The eligibility criteria were the absence of other retinopathy or systemic autoimmune diseases. Results: All patients had a long-standing diagnosis of SLE and had been taking hydroxychloroquine at a dose exceeding the American Academy of Ophthalmology recommendations...
2023: Journal of Vitreoretinal Diseases
https://read.qxmd.com/read/37836548/the-acute-effect-of-hydroxychloroquine-sulfate-on-hunger-the-plasma-concentration-of-orexigenic-peptides-and-hedonic-food-intake-a-pilot-study
#5
RANDOMIZED CONTROLLED TRIAL
Emily Ruilova Sosoranga, Wout Verbeure, Hannelore Geysen, Theo Thijs, Christophe Matthys, Inge Depoortere, Jan Tack
The direct infusion of bitter solutions in the gastrointestinal tract can reduce the secretion of orexigenic hormones and influence appetite and food intake. We aimed to explore whether oral ingestion of the bitter tastant hydroxychloroquine sulfate can exert similar effects. Ten lean adult women were included in this double-blind, randomized, two-visit, crossover study. After an overnight fast, each volunteer received film-coated tablets containing 400 mg of hydroxychloroquine sulfate (Plaquenil® ) or placebo...
October 5, 2023: Nutrients
https://read.qxmd.com/read/37734481/panniculitic-gamma-delta-t-cell-lymphoma-with-concomitant-features-of-autoimmune-disease-emphasizing-a-pathophysiologic-continuum-with-the-panniculitic-t-cell-lymphomas
#6
JOURNAL ARTICLE
Cynthia Magro, Taylor Kalomeris
There are T-cell lymphomas, which exhibit unique homing properties of the neoplastic lymphocytes for the subcutaneous fat. Primary cutaneous gamma delta T-cell lymphomas of the fat (PGD-TCL) typically have an aggressive clinical course; the more indolent variant is subcutaneous panniculitis like T-cell lymphoma (SPTCL), comprising T-cells of the alpha beta subset. These t wo forms of subcutaneous T-cell neoplasms exhibit many overlapping histologic features with lupus profundus (LP); it has been previously suggested by one of the authors that lupus profundus is a form of a panniculitic T-cell dyscrasia...
September 19, 2023: Clinics in Dermatology
https://read.qxmd.com/read/37716581/autoimmune-disease-including-lupus-panniculitis-in-association-with-panniculitic-cell-lymphomas
#7
JOURNAL ARTICLE
Cynthia M Magro, Taylor Kalomeris, Alicia Dillard
Some T cell lymphomas exhibit unique homing properties of the neoplastic lymphocytes for the subcutaneous fat. There are two primary forms of subcutaneous panniculitic lymphomas of T cell origin. The first falls under the designation of primary cutaneous gamma delta T cell lymphomas of the fat (PGD-TCL). The neoplastic cells are double negative for CD8+ gamma delta T cells and often have an aggressive clinical course. The other form of panniculitis, T cell lymphoma, falls under the designation of subcutaneous panniculitis-like T cell lymphoma (SPTCL)...
September 14, 2023: Clinics in Dermatology
https://read.qxmd.com/read/37488645/overlap-syndrome-of-autoimmune-hepatitis-and-primary-biliary-cholangitis-complicated-with-atypical-hepatocellular-carcinoma-a-case-report
#8
JOURNAL ARTICLE
Teodora Surdea-Blaga, Roxana L Cărăguț, Cosmin Caraiani, Zeno Spârchez, Nadim Al Hajjar, Dan L Dumitrașcu
BACKGROUND: Hepatocellular carcinoma (HCC) is a primary tumor of the liver. The majority of HCCs are associated most frequently with chronic B or C viral hepatitis, alcohol intake or aflatoxin exposure. Cirrhosis is a strong risk factor associated with HCC. The causes of liver cirrhosis are chronic viral hepatitis, alcohol intake, metabolic diseases (NAFLD), hemocromathosis, alfa 1 antitrypsisn deficiency. All aetiologic forms of cirrhosis are at risk to be complicated by HCC development, but the risk is higher for patients diagnosed with chronic viral hepatitis...
July 25, 2023: Journal of Medical Case Reports
https://read.qxmd.com/read/37405706/an-atypical-cause-of%C3%A2-hoarseness-in%C3%A2-a-patient-with-thyroid-nodules
#9
JOURNAL ARTICLE
Shruti M Gandhi, Edina Paal, Eric S Nylen
Hoarseness due to vocal fold paresis (VFP) has a multitude of etiologies including systemic lupus erythematosus (SLE). During a clinical evaluation of a 58-year-old woman with long-standing hoarseness, an incidental finding of thyroid nodules was found to have VFP. Direct laryngoscopy and vocal fold biopsy confirmed the source was an inflammatory process involving the cricoarytenoid joint of the right hemilarynx. A presumptive diagnosis of SLE was made 3 years before meeting the clinical criteria of overt SLE...
July 5, 2023: Military Medicine
https://read.qxmd.com/read/37223159/pleural-and-pericardial-effusion-with-covid-19-and-systemic-lupus-erythematosus-and-its-recurrence-a-case-study
#10
Connor Yost, Darin Vercillo, Abdulelah Abuqare, Mckenna B Yost, Avery N Love
As a chronic autoimmune disease, systemic lupus erythematosus (SLE) primarily affects young women and does not discriminate against any particular organs. In December 2019, coronavirus disease 2019 (COVID-19) spread worldwide, with many speculations of cardiac involvement in the pathogenesis of infection. Moreover, in cases where cardiac symptoms were described, they consisted solely of chest pain or a general deterioration in health if the patient presented with pleural effusion or pericardial effusion. Our patient, a 25-year-old Hispanic woman, initially complained of chest pain, cough, and shortness of breath...
April 2023: Curēus
https://read.qxmd.com/read/36984552/the-hit-study-the-hydroxychloroquine-effect-in-the-treatment-of-patients-with-age-related-macular-degeneration-a-randomized-controlled-trial
#11
RANDOMIZED CONTROLLED TRIAL
Tal Yahalomi, Yoav Pikkel, Roee Arnon, Dafi Porat, Joseph Pikkel
Background and Objectives: Decreased age-related macular degeneration (AMD) has been reported in individuals with rheumatoid arthritis treated with hydroxychloroquine (HCQ, plaquenil). Materials and Methods: In a randomized controlled trial with a parallel study design, we assessed visual acuity, central macular thickness measured with macular optical coherence tomography (OCT), and the number and size of drusen, following treatment with HCQ or a placebo in individuals with AMD. The patients received a daily dosage of 400 mg hydroxychloroquine (study group) or placebo (control group) during 12 months, and underwent complete ophthalmic examinations at 3, 6, 9, 12 and 24 months after initiation of treatment...
March 11, 2023: Medicina
https://read.qxmd.com/read/36505592/new-onset-systemic-lupus-erythematosus-presenting-with-pseudo-pseudo-meigs-syndrome
#12
Nouf Al Hammadi
Systemic lupus erythematosus is a complex disease and can present with almost any organ involvement, including serosal inflammation. Our patient is not known to have any medical problems, presented for the first time with pseudo-pseudo Meigs' syndrome (PPMS), and after extensive workup to rule out other possibilities like infection and malignancy, she was found to have systemic lupus erythematosus. Several other cases have been reported in the literature; our patient had to have a pleural biopsy for completion of workup...
September 2022: Journal of Family Medicine and Primary Care
https://read.qxmd.com/read/36107602/a-case-report-of-secondary-synchronous-diagnosis-of-multiple-myeloma-and-systemic-lupus-erythematosus-after-breast-cancer-treatment-a-care-compliant-article
#13
JOURNAL ARTICLE
Pei-Hsin Chen, Heng-Hsin Tung, Chin-Husan Lin, Kuan-Po Huang, Yung-Lun Ni, Chin-Yao Lin
INTRODUCTION: Breast cancer (BC) is the most diagnosed cancer worldwide. Multiple myeloma (MM) is a hematologic malignancy characterized by the overproduction of monoclonal antibodies in the bone marrow. Systemic lupus erythematosus (SLE) is distinguished by the aberrant activity of the immune system with heterogeneous clinical manifestations. The coexistence of more than one major illness in a patient can present a diagnostic challenge for clinical physicians, especially when the comorbid diseases share a similar clinical presentation...
September 2, 2022: Medicine (Baltimore)
https://read.qxmd.com/read/35702724/nivolumab-induced-de-novo-discoid-lupus-erythematosus
#14
Jaya Manjunath, Mark Mochel, Fnu Nutan
An increasing number of checkpoint inhibitor-induced subacute cutaneous lupus erythematosus events have been reported. We present the first case of nivolumab-induced discoid lupus erythematosus in a patient with hepatocellular carcinoma. The patient presents with violaceous hypopigmented plaques on the pinna bilaterally, hypopigmented plaques with central hyperpigmentation on the posterior neck, and other hypopigmented plaques on the face, forearms, and hands. For management, nivolumab was held for 2 months, and Plaquenil and topical steroids were added...
2022: Case Reports in Dermatology
https://read.qxmd.com/read/35483117/effect-of-hydroxychloroquine-or-chloroquine-and-short-wavelength-light-on-in-vivo-retinal-function-and-structure-in-mouse-eyes
#15
JOURNAL ARTICLE
Wilson Heriot, Vickie Hy Wong, Zheng He, Anh Hoang, Jeremiah Kh Lim, Tomoharu Nishimura, Da Zhao, Andrew B Metha, Bang V Bui
CLINICAL RELEVANCE: The use of chloroquine or hydroxychloroquine can lead to both acute and chronic changes to both retinal structure and function. BACKGROUND: Chloroquine (CQ) and hydroxychloroquine (HCQ) have the potential for retina toxicity. The acute impact of short-term drug exposure (2-4 weeks) on in vivo retinal structure and function and assess whether short wavelength light exposure further exacerbates any structural and functional changes was assessed in a murine model...
April 28, 2022: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://read.qxmd.com/read/35085211/expanded-table-some-conventional-dmards-for-rheumatoid-arthritis
#16
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
November 15, 2021: Medical Letter on Drugs and Therapeutics
https://read.qxmd.com/read/35085210/drugs-for-rheumatoid-arthritis
#17
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
November 15, 2021: Medical Letter on Drugs and Therapeutics
https://read.qxmd.com/read/34766646/analysis-of-long-term-antibody-response-in-covid-19-patients-by-symptoms-grade-gender-age-bmi-and-medication
#18
JOURNAL ARTICLE
Tuba Ozgocer, Şeyda Nur Dagli, Mehmet Reşat Ceylan, Faruk Disli, Cihat Ucar, Sedat Yildiz
The first aim of the study was to analyze the change in antibody titer at 15-day intervals until 60 days post symptom onset (PSO) The second aim was to analyze relationship between antibody titer and symptom grade, gender, age, BMI, medications, vitamin supplements, and herbal therapies. Blood samples were collected from 43 patients (5 mild, 21 moderate, 17 severe diseases), 18 women (41.9 %), and 25 men (58.1 %), on 15, 30, 45, and 60 days PSO after COVID-19 infection. The serum antibody titers were determined by measuring the COVID-19 IgG antibodies by ELISA...
November 12, 2021: Journal of Medical Virology
https://read.qxmd.com/read/34557260/risk-versus-benefit-of-using-hydroxychloroquine-to-treat-patients-with-covid-19
#19
REVIEW
George G Zhanel, Michael A Zhanel, Kevin F Boreskie, Joseph P Lynch, James A Karlowsky
Hydroxychloroquine (HCQ), also known by its trade name Plaquenil®, has been used for over 50 years as a treatment for malaria, systemic lupus erythematosus, and rheumatoid arthritis. As the COVID-19 pandemic emerged in the United States and globally in early 2020, HCQ began to garner attention as a potential treatment and as prophylaxis against COVID-19. Preliminary data indicated that HCQ as well as chloroquine (CQ) possessed in vitro antiviral activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)...
2021: Canadian Journal of Infectious Diseases & Medical Microbiology
https://read.qxmd.com/read/34550961/anifrolumab-saphnelo-for-systemic-lupus-erythematosus
#20
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
September 20, 2021: Medical Letter on Drugs and Therapeutics
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