Yue Li, Jiaxiang Pan, J J Jiajia Yu, Xize Wu, Guanlin Yang, Xue Pan, Guoyuan Sui, Mingyang Wang, Meijia Cheng, Shu Zhu, He Tai, Honghe Xiao, Lili Xu, Jin Wu, Yongju Yang, Jing Tang, Lihong Gong, Lianqun Jia, Dongyu Min
This study aims to investigate the mechanism of the anti-atherosclerosis effect of Huayu Qutan Recipe (HYQT) on the inhibition of foam cell formation. In vivo, the mice were randomly divided into three groups: CTRL group, MOD group and HYQT group. The HYQT group received HYQT oral administration twice a day (20.54 g/kg/d), and the plaque formation in ApoE-/- mice was observed using haematoxylin-eosin (HE) staining and oil red O (ORO) staining. The co-localization of aortic macrophages and lipid droplets (LDs) was examined using fluorescent labelling of CD11b and BODIPY fluorescence probe...
April 2024: Journal of Cellular and Molecular Medicine