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https://www.readbyqxmd.com/read/28225988/estimation-of-cardiovascular-risk-and-detection-of-subclinical-carotid-atheromatosis-in-patients-with-diabetes-without-a-history-of-cardiovascular-disease
#1
Walter Masson, Salvador De Francesca, Micaela Molinero, Daniel Siniawski, Andrés Mulassi, Frank Espinoza Morales, Melina Huerin, Martín Lobo, Graciela Molinero
Objectives: Cardiovascular risk estimated by several scores in patients with diabetes mellitus without a cardiovascular disease history and the association with carotid atherosclerotic plaque (CAP) were the aims of this study. Materials and methods: Cardiovascular risk was calculate using United Kingdom Prospective Diabetes Study (UKPDS) risk engine, Framingham risk score for cardiovascular (FSCV) and coronary disease (FSCD), and the new score (NS) proposed by the 2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol...
February 13, 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28197833/auxiliendo-primum-non-nocere-a-preliminary-view-of-the-devote-trial-comparing-cardiovascular-safety-of-insulin-degludec-versus-insulin-glargine-in-type-2-diabetes
#2
Sanjay Kalra
A demonstration of cardiovascular safety is mandatory for all newly developed glucose-lowering agents, including insulin analogues. The vascular benefit of insulin is evident from the Diabetes Control and Complication Trial (DCCT) and United Kingdom Prospective Diabetes Study (UKPDS), and the cardiovascular safety of insulin glargine has been demonstrated in individuals with newly diagnosed diabetes or prediabetes in the ORIGIN trial (Outcome Reduction with an Initial Glargine Intervention). The top-line results of DEVOTE (Trial Comparing Cardiovascular Safety of Insulin Degludec vs...
February 14, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/28056470/-anti-diabetic-medication-during-the-first-four-years-of-treatment-a-study-based-on-claims-data
#3
Veronika Lappe, Ingrid Köster, Ingrid Schubert
Background Ever since the UKPDS study reassessed the usefulness of the substance metformin in 1998, it has been the first-line medication in anti-diabetic treatment. In addition, new classes and agents released on the market have given rise to new treatment options. The present study investigates prescription practice at the onset of treatment and in the years thereafter and measures it against German diabetes guidelines. Database and Methods Database: Statutory health insurance sample AOK/KV Hesse; Ages: 40 and over (N = 142514)...
January 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28026908/an-alternative-approach-to-modelling-hba1c-trajectories-in-patients-with-type-2-diabetes-mellitus
#4
Phil McEwan, Hayley Bennett, Lei Qin, Klas Bergenheim, Jason Gordon, Marc Evans
AIMS: Time-dependent HbA1c trajectories in health economic models of type 2 diabetes mellitus (T2DM) are typically informed by the UK Prospective Diabetes Study (UKPDS). However, this approach may not accurately predict HbA1c progression in patients who do not conform to the demographic profile of the original UKPDS cohort. This study aimed to develop an alternative mathematical model (MM) to simulate HbA1c progression in T2DM. MATERIALS AND METHODS: A systematic literature review identified studies, published from 2005 to 2015, that reported HbA1c in adult T2DM patients over a minimum duration of 18 months...
December 27, 2016: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28024655/prevalence-by-computed-tomographic-angiography-of-coronary-plaques-in-south-asian-and-white-patients-with-type-2-diabetes-mellitus-at-low-and-high-risk-using-four-cardiovascular-risk-scores-ukpds-frs-ascvd-and-jbs3
#5
Sanjay N Gobardhan, Aukelien C Dimitriu-Leen, Alexander R van Rosendael, Erik W van Zwet, Cornelis J Roos, Pranobe V Oemrawsingh, Aan V Kharagjitsingh, J Wouter Jukema, Victoria Delgado, Martin J Schalij, Jeroen J Bax, Arthur J H A Scholte
The aim of this study was to explore the association between various cardiovascular (CV) risk scores and coronary atherosclerotic burden on coronary computed tomography angiography (CTA) in South Asians with type 2 diabetes mellitus and matched whites. Asymptomatic type 2 diabetic South Asians and whites were matched for age, gender, body mass index, hypertension, and hypercholesterolemia. Ten-year CV risk was estimated using different risk scores (United Kingdom Prospective Diabetes Study [UKPDS], Framingham Risk Score [FRS], AtheroSclerotic CardioVascular Disease [ASCVD], and Joint British Societies for the prevention of CVD [JBS3]) and categorized into low- and high-risk groups...
December 2, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/28002036/serum-levels-of-oxidative-stress-markers-in-patients-with-type-2-diabetes-mellitus-and-non-alcoholic-steatohepatitis
#6
F Casoinic, D Sampelean, Anca D Buzoianu, N Hancu, Dorina Baston
INTRODUCTION: Oxidative stress is one of the key mechanisms responsible for disease progression in non-alcoholic fatty liver disease. The aim of this study was to evaluate the serum levels of oxidative stress markers in patients with type 2 diabetes mellitus (DMT2) and non-alcoholic steatohepatitis (NASH) and test their relationships with clinical and biochemical patient characteristics, compared to patients with DMT2 without non-alcoholic fatty liver disease (NAFLD), and controls. MATERIALS AND METHODS: In all, 60 consecutive patients with DMT2 and NASH, 55 with DMT2 without NAFLD, and 50 age-and-gender-matched healthy subjects participated in the study...
December 1, 2016: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/27957711/the-role-of-beta-blockers-in-the-treatment-of-hypertension
#7
John M Cruickshank
IMPORTANCE: Two major guide-line committees (JNC-8 and NICE UK) have dropped beta-blockers as first-line therapy in the treatment of hypertension. Also, recent meta-analyses (that do not take age into account) have concluded that beta-blockers are inappropriate first-line agents in the treatment of hypertension. This review seeks to shed some light on the "rights and wrongs" of such actions and conclusions. OBJECTIVES: Because the pathophysiology of primary/essential hypertension differs in elderly and younger subjects, the latter being closely linked to obesity and increased sympathetic nerve activity, the author sought to clarify the efficacy of beta-blockers in the younger/middle-aged group in reducing the risk of death, and cardiovascular end-points...
December 13, 2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27774422/complementary-and-alternative-medicine-in-indian-parkinson-s-disease-patients
#8
Awadh Kishor Pandit, Deepti Vibha, Achal Kumar Srivastava, Garima Shukla, Vinay Goyal, Madhuri Behari
Use of complementary and alternative medicine (CAM; bǔ chōng yǔ tì dài yī xué) in Parkinson disease (PD) ranged 40-70%. The objective of this study was to determine the frequency, types and factors associated with the use of CAM in Indian PD patients. PD patients, fulfilling UKPD-Society brain-bank diagnostic-criteria, attending Movement-disorders clinic of a tertiary-care teaching hospital in India from 1st May to 15th December 2012 were enrolled. Information on socio-demographic, clinical data and treatment along with factors (source of information, benefits, harms, reason for use and cost) associated with CAM use were recorded...
October 2016: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/27749939/quality-of-diabetes-care-in-germany-improved-from-2000-to-2007-to-2014-but-improvements-diminished-since-2007-evidence-from-the-population-based-kora-studies
#9
Michael Laxy, Gabriella Knoll, Michaela Schunk, Christa Meisinger, Cornelia Huth, Rolf Holle
OBJECTIVE: Little is known about the development of the quality of diabetes care in Germany. The aim of this study is to analyze time trends in patient self-management, physician-delivered care, medication, risk factor control, complications and quality of life from 2000 to 2014. METHODS: Analyses are based on data from individuals with type 2 diabetes of the population-based KORA S4 (1999-2001, n = 150), F4 (2006-2008, n = 203), FF4 (2013/14, n = 212) cohort study...
2016: PloS One
https://www.readbyqxmd.com/read/27727281/delivering-diabetes-education-through-nurse-led-telecoaching-cost-effectiveness-analysis
#10
Irina Odnoletkova, Dirk Ramaekers, Frank Nobels, Geert Goderis, Bert Aertgeerts, Lieven Annemans
BACKGROUND: People with diabetes have a high risk of developing micro- and macrovascular complications associated with diminished life expectancy and elevated treatment costs. Patient education programs can improve diabetes control in the short term, but their cost-effectiveness is uncertain. Our study aimed to analyze the lifelong cost-effectiveness of a nurse-led telecoaching program compared to usual care in people with type 2 diabetes from the perspective of the Belgian healthcare system...
2016: PloS One
https://www.readbyqxmd.com/read/27716211/a-19-snp-coronary-heart-disease-gene-score-profile-in-subjects-with-type-2-diabetes-the-coronary-heart-disease-risk-in-type-2-diabetes-cordia-study-study-baseline-characteristics
#11
RANDOMIZED CONTROLLED TRIAL
Katherine E Beaney, Claire E Ward, Dauda A S Bappa, Nadine McGale, Anna K Davies, Shashivadan P Hirani, KaWah Li, Philip Howard, Dwaine R Vance, Martin A Crockard, John V Lamont, Stanton Newman, Steve E Humphries
BACKGROUND: The coronary risk in diabetes (CoRDia) trial (n = 211) compares the effectiveness of usual diabetes care with a self-management intervention (SMI), with and without personalised risk information (including genetics), on clinical and behavioural outcomes. Here we present an assessment of randomisation, the cardiac risk genotyping assay, and the genetic characteristics of the recruits. METHODS: Ten-year coronary heart disease (CHD) risk was calculated using the UKPDS score...
October 3, 2016: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/27678079/the-cost-effectiveness-of-hospital-based-telephone-coaching-for-people-with-type-2-diabetes-a-10%C3%A2-year-modelling-analysis
#12
J E Varney, D Liew, T J Weiland, W J Inder, G A Jelinek
BACKGROUND: Type 2 diabetes (T2DM) is a burdensome condition for individuals to live with and an increasingly costly condition for health services to treat. Cost-effective treatment strategies are required to delay the onset and slow the progression of diabetes related complications. The Diabetes Telephone Coaching Study (DTCS) demonstrated that telephone coaching is an intervention that may improve the risk factor status and diabetes management practices of people with T2DM. Measuring the cost effectiveness of this intervention is important to inform funding decisions that may facilitate the translation of this research into clinical practice...
September 27, 2016: BMC Health Services Research
https://www.readbyqxmd.com/read/27630880/association-of-risk-estimates-of-three-different-cardiovascular-risk-assessment-tools-with-carotid-intima-media-thickness-in-patients-with-type-2-diabetes
#13
Herath Mudiyanselage Meththananda Herath, Thilak Priyantha Weerarathna, Ranasinghe Bethmi Arachige Thilini Dulanjalee, Madumekala Rupasinghe Jayawardana, Udara Priyadarshani Edirisingha, Madushanka Rathnayake
INTRODUCTION: Risk assessment tools used to calculate the Cardiovascular Disease (CVD) risk such as the Framingham Risk Score (FRS), United Kingdom Prospective Diabetes study (UKPDS) risk engine and the World Health Organization (WHO) risk score have not been tested on their ability to detect subclinical atherosclerosis in most developing countries. AIM: To study the association between the calculated CVD risk scores using each of these tools and Carotid Intima Medial Thickness (CIMT), a surrogate marker of atherosclerosis, in a group of patients with Type 2 diabetes (T2DM) in Sri Lanka...
July 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27627074/-clinical-contribution-of-new-basal-analogue-insulin
#14
Alena Adamíková
UNLABELLED: Chronic long term hyperglycemia plays a key role in the pathogenesis of micro and macrovascular complications. The UKPDS study and its further analysis has proved that reduction of the value of glycated hemoglobin by 1 % leads to a 14 % reduction of the risk of myocardial infarction and a 37 % reduction of the risk of microvascular complications. Effective control of glycaemia, optimal value of pre-prandial, postprandial glycaemia, and low variability from the start of the disease has a long term beneficial impact...
2016: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27579542/metformin-nonglycemic-effects-and-potential-novel-indications
#15
Abeer Anabtawi, John M Miles
OBJECTIVE: Metformin is the most commonly prescribed drug for the treatment of type 2 diabetes because of its apparent robust effects in reducing cardiovascular risk. This review examines the current literature regarding the nonglycemic effects and potential novel indications for metformin. METHODS: Review of the literature, with a focus on metformin use in Stage 3 chronic kidney disease (CKD-3) and heart failure (HF). RESULTS: The United Kingdom Prospective Diabetes Study suggests that metformin reduces the risk of myocardial infarction, and more recent retrospective studies have shown an association between metformin use and a reduction in stroke, atrial fibrillation and all-cause mortality...
August 2016: Endocrine Practice
https://www.readbyqxmd.com/read/27558630/cardiovascular-risk-outcome-and-program-evaluation-of-a-cluster-randomised-controlled-trial-of-a-community-based-lay-peer-led-program-for-people-with-diabetes
#16
M A Riddell, J A Dunbar, P Absetz, R Wolfe, H Li, M Brand, Z Aziz, B Oldenburg
BACKGROUND: The 2013 Global Burden of Disease Study demonstrated the increasing burden of diabetes and the challenge it poses to the health systems of all countries. The chronic and complex nature of diabetes requires active self-management by patients in addition to clinical management in order to achieve optimal glycaemic control and appropriate use of available clinical services. This study is an evaluation of a "real world" peer support program aimed at improving the control and management of type 2 diabetes (T2DM) in Australia...
2016: BMC Public Health
https://www.readbyqxmd.com/read/27553599/glycemic-control-for-patients-with-type-2-diabetes-mellitus-our-evolving-faith-in-the-face-of-evidence
#17
René Rodríguez-Gutiérrez, Victor M Montori
BACKGROUND: We sought to determine the concordance between the accumulating evidence about the impact of tight versus less tight glycemic control in patients with type 2 diabetes mellitus since the publication of UKPDS (UK Prospective Diabetes Study) in 1998 until 2015 with the views about that evidence published in journal articles and practice guidelines. METHODS AND RESULTS: We searched in top general medicine and specialty journals for articles referring to glycemic control appearing between 2006 and 2015 and identified the latest practice guidelines...
September 2016: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/27486519/pers-o-persistent-sitagliptin-treatment-outcomes-observational-retrospective-study-on-cardiovascular-risk-evolution-in-patients-with-type-2-diabetes-on-persistent-sitagliptin-treatment
#18
Giulia Buonaiuto, Valentina De Mori, Alessandra Braus, Annalisa Balini, Denise Berzi, Rita Carpinteri, Franco Forloni, Giancarla Meregalli, Gian Luca Ronco, Antonio C Bossi
OBJECTIVES: The UK Prospective Diabetes Study (UKPDS) Risk Engine (RE) provides the best risk estimates available for people with type 2 diabetes (T2D), so it was applied to patients on persistent sitagliptin treatment. DESIGN: A 'real-world' retrospective, observational, single-center study. SETTING: The study was performed in a general hospital in Northern Italy in order: (1) to validate UKPDS RE in a cohort of Italian participants with T2D without prespecified diabetes duration, with/without cardiovascular (CV) disease, treated with sitagliptin; (2) to confirm CV risk gender difference; (3) to evaluate the effect on metabolic control and on CV risk evolution obtained by 'add-on' persistent sitagliptin treatment...
2016: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/27085771/kinase-sumo-networks-in-diabetes-mediated-cardiovascular-disease
#19
REVIEW
Eugene Chang, Jun-Ichi Abe
Type II diabetes mellitus (DM) is a common comorbidity in patients with cardiovascular disease (CVD). Epidemiological studies including the Framingham, UKPDS, and MRFIT studies have shown diabetes to be an independent risk factor for cardiovascular disease associated with increased incidence of morbidity and mortality. However, major randomized controlled clinical trials including ADVANCE, VAD, and ACCORD have failed to demonstrate a significant reduction in CVD complications from longstanding DM with strict glycemic control...
May 2016: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/27033025/a-post-hoc-analysis-of-saxagliptin-efficacy-and-safety-in-patients-with-type-2-diabetes-stratified-by-ukpds-10-year-cardiovascular-risk-score
#20
E Bonora, B Bryzinski, B Hirshberg, W Cook
BACKGROUND AND AIMS: To assess the efficacy and safety of saxagliptin 2.5 and 5 mg/d in patients with type 2 diabetes mellitus (T2DM) and high risk of coronary heart disease (CHD) or stroke as estimated by the United Kingdom Prospective Diabetes Study (UKPDS) risk engine. METHODS AND RESULTS: Post hoc analysis of data pooled from 5 previously reported phase 3, randomized, placebo-controlled, 24-week studies was conducted. Patients were stratified into subgroups by UKPDS 10-year CHD and/or stroke risk ≥20% and CHD and stroke risk <20%...
May 2016: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
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