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https://www.readbyqxmd.com/read/28916434/effects-of-icos-t-cell-depletion-via-afucosylated-monoclonal-antibody-medi-570-on-pregnant-cynomolgus-monkeys-and-the-developing-offspring
#1
Simone M Nicholson, Gianluca Carlesso, Lily I Cheng, Halie Cook, Karma DaCosta, Joel Leininger, Kathleen McKeever, Stephen Weasel Scott, Devon Taylor, Katie Streicher, Steve Eck, Molly Reed, Raffaella Faggioni, Ronald Herbst, Rakesh Dixit, Patricia C Ryan
MEDI-570 is a fully human afucosylated monoclonal antibody (MAb) against Inducible T-cell costimulator (ICOS), highly expressed on CD4+ T follicular helper (TFH) cells. Effects of MEDI-570 were evaluated in an enhanced pre-postnatal development toxicity (ePPND) study in cynomolgus monkeys. Administration to pregnant monkeys did cause any abortifacient effects. Changes in hematology and peripheral blood T lymphocyte subsets in maternal animals and infants and the attenuated infant IgG immune response to keyhole limpet hemocyanin (KLH) were attributed to MEDI-570 pharmacology...
September 12, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28913141/outcome-of-intracytoplasmic-sperm-injection-after-preinstillation-of-a-gonadotropin-releasing-hormone-agonist-in-the-uterine-cavity-just-before-embryo-transfer
#2
Pınar Çağlar Aytaç, Bülent Haydardedeoğlu, Halis Özdemir, Esra Bulgan Kılıçdağ
OBJECTIVE: To evaluate the effects of a gonadotropin releasing hormone agonist (GnRHa) injection prior to embryo transfer on implantation and pregnancy rate. MATERIALS AND METHODS: We performed a retrospective analysis of patients undergoing in vitro fertilization (IVF) therapy with and without GnRHa preinstallation into the uterine cavity just before embryo transfer between January 2012 and March 2013 in a single IVF center of a university hospital. Patients were evaluated based upon implantation, pregnancy, live birth, and miscarriage rates...
June 2017: Turk J Obstet Gynecol
https://www.readbyqxmd.com/read/28904750/phenology-of-brown-marmorated-stink-bug-described-using-female-reproductive-development
#3
Anne L Nielsen, Shelby Fleischer, George C Hamilton, Tori Hancock, Gregorz Krawczyk, Jana C Lee, Emily Ogburn, John M Pote, Amy Raudenbush, Ann Rucker, Michael Saunders, Victoria P Skillman, Jeanne Sullivan, Jody Timer, James Walgenbach, Nik G Wiman, Tracy C Leskey
Temperature-based degree-day models describe insect seasonality and to predict key phenological events. We expand on the use of a temperature-based process defining timing of reproduction through the incorporation of female reproductive physiology for the invasive pentatomid species Halyomorpha halys, the brown marmorated stink bug. A five-stage ranking system based on ovary development was able to distinguish between the reproductive statuses of field-collected females. Application of this ranking method described aspects of H...
September 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28878175/modelled-cost-effectiveness-of-a-package-size-cap-and-a-kilojoule-reduction-intervention-to-reduce-energy-intake-from-sugar-sweetened-beverages-in-australia
#4
Michelle Crino, Ana Maria Mantilla Herrera, Jaithri Ananthapavan, Jason H Y Wu, Bruce Neal, Yong Yi Lee, Miaobing Zheng, Anita Lal, Gary Sacks
Interventions targeting portion size and energy density of food and beverage products have been identified as a promising approach for obesity prevention. This study modelled the potential cost-effectiveness of: a package size cap on single-serve sugar sweetened beverages (SSBs) >375 mL ( package size cap ), and product reformulation to reduce energy content of packaged SSBs ( energy reduction ). The cost-effectiveness of each intervention was modelled for the 2010 Australia population using a multi-state life table Markov model with a lifetime time horizon...
September 6, 2017: Nutrients
https://www.readbyqxmd.com/read/28861303/flouroscopy-free-technique-is-safe-and-feasible-in-retrograde-intrarenal-surgery-for-renal-stones
#5
Hacı İbrahim Çimen, Fikret Halis, Hasan Salih Sağlam, Ahmet Gökçe
OBJECTIVE: The aim of this study was to present outcomes of our patients who had undergone retrograde intrarenal surgery (RIRS) with fluoroscopy-free technique and evaluate the efficacy and safety of the technique. MATERIAL AND METHODS: Between January 2013 and June 2015 the outcomes of 93 patients who had undergone RIRS with fluoroscopy-free technique were retrospectively evaluated. Our RIRS technique involved preoperative assessment of ureter by semi-rigid ureteroscope, inserting guidewire through semi-rigid ureteroscope, inserting ureteral access sheath over the guidewire with the visiual guidance of semi-rigid ureteroscope, passing flexible ureteroscope through the sheath, dusting the stone with holmium laser, rechecking the ureter with semi-rigid ureteroscope and inserting double J stent through semi-rigid ureteroscope...
September 2017: Turkish Journal of Urology
https://www.readbyqxmd.com/read/28852110/global-invasion-network-of-the-brown-marmorated-stink-bug-halyomorpha-halys
#6
Rafael E Valentin, Anne L Nielsen, Nik G Wiman, Doo-Hyung Lee, Dina M Fonseca
Human mediated transportation into novel habitats is a prerequisite for the establishment of non-native species that become invasive, so knowledge of common sources may allow prevention. The brown marmorated stink bug (BMSB, Halyomorpha halys) is an East Asian species now established across North America and Europe, that in the Eastern United States of America (US) and Italy is causing significant economic losses to agriculture. After US populations were shown to originate from Northern China, others have tried to source BMSB populations now in Canada, Switzerland, Italy, France, Greece, and Hungary...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821189/y-chromosome-markers-for-the-red-fox
#7
Halie M Rando, Jeremy T Stutchman, Estelle R Bastounes, Jennifer L Johnson, Carlos A Driscoll, Christina S Barr, Lyudmila N Trut, Benjamin N Sacks, Anna V Kukekova
The de novo assembly of the red fox (Vulpes vulpes) genome has facilitated the development of genomic tools for the species. Efforts to identify the population history of red foxes in North America have previously been limited by a lack of information about the red fox Y-chromosome sequence. However, a megabase of red fox Y-chromosome sequence was recently identified over 2 scaffolds in the reference genome. Here, these scaffolds were scanned for repeated motifs, revealing 194 likely microsatellites. Twenty-three of these loci were selected for primer development and, after testing, produced a panel of 11 novel markers that were analyzed alongside 2 markers previously developed for the red fox from dog Y-chromosome sequence...
September 1, 2017: Journal of Heredity
https://www.readbyqxmd.com/read/28820992/bioavailability-of-dissolved-organic-nitrogen-don-in-wastewaters-from-animal-feedlots-and-storage-lagoons
#8
Jingyi Sun, Eakalak Khan, Senay Simsek, Jae-Bom Ohm, Halis Simsek
Dissolved organic nitrogen (DON) from animal wastes can contribute to pollution of surface waters. Bioavailable DON (ABDON) is a portion of DON utilized by algae with or without bacteria. This study determined DON and ABDON levels in animal wastewater collected from two different sources: an animal feedlot wastewater storage tank and a sheep wastewater storage lagoon. Inocula for the ABDON bioassays were comprised of individual species and several combinations involving two algae (Chlamydomonas reinhardtii and Chlorella vulgaris) and a mixed liquor suspended solids (MLSS) bacterial culture...
November 2017: Chemosphere
https://www.readbyqxmd.com/read/28808440/corrigendum-coupling-developmental-physiology-photoperiod-and-temperature-to-model-phenology-and-dynamics-of-an-invasive-heteropteran-halyomorpha-halys
#9
Anne L Nielsen, Shi Chen, Shelby J Fleischer
[This corrects the article on p. 165 in vol. 7, PMID: 27242539.].
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28768084/changes-in-angiotensin-ii-and-angiotensin-converting-enzyme-of-different-tissues-after-prolonged-hyperoxia-exposure
#10
Cui-Hong Han, Pei-Xi Zhang, Ying Liu, Juan Zheng, Kan Liu, Dunbiao Wei, Tongju Qiao, Bo Peng, Wenwu Liu
Current study findings concerning changes in the renin-angiotensin system (RAS) in cases of hyperoxic acute lung injury (HALI) have shown conflicting results. This study aimed to detect the angiotensin II (Ang II) and angiotensin-converting enzyme (ACE) in a rat HALI model. Healthy male Sprague-Dawley rats were randomly assigned into three groups: the control group, HALI group and hyperbaric oxygen preconditioning (HBO₂-PC) group. HALI was induced by exposure to pure oxygen at 250 kPa for six hours. In the HBO₂-PC group, rats were exposed to oxygen at 250 kPa for 60 minutes twice daily for two consecutive days; HALI was induced at 24 hours after the last oxygen exposure...
January 2017: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
https://www.readbyqxmd.com/read/28768083/oridonin-protects-the-lung-against-hyperoxia-induced-injury-in-a-mouse-model
#11
Ying Liu, Pei-Xi Zhang, Cui-Hang Han, Dunbiao Wei, Tongju Qiao, Bo Peng, Kan Liu, Juan Zheng, Wenwu Liu
Hyperoxic acute lung injury (HALI) is caused by prolonged exposure to high oxygen partial pressure. This study was undertaken to investigate the protective effects of oridonin on HALI in a mouse model. Mice were randomly divided into three groups: the control group, HALI group and oridonin (ORI) group. HALI was induced by exposing mice to pure oxygen at 2.5 atmospheres absolute (ATA) for six hours in the HALI and ORI groups. In the ORI group, mice were intraperitoneally injected with ORI at 10 mg/kg twice daily after hyperoxic exposure...
January 2017: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
https://www.readbyqxmd.com/read/28758579/perspectives-of-medieval-persian-medicine-on-multiple-sclerosis
#12
Mohammad Ali Sahraian, Mohsen Parviz, Behnam Sheibani, Nicoline Schiess, Zahra Ghorbanifar, Mohammad Kamalinejad, Esmail Nazem, Omid Sadeghpour, Hossein Rezaeizadeh
INTRODUCTION: Traditional Persian Medicine (TPM) was the prevailing practice of medicine in the Eurasia region up through the 18th century, a practice of medicine stemming back to Hippocrates and to the 5000 year old civilization of the region. It is a school of medicine which touches on many a delicate points which may seem unimaginable within the realm of modern allopathic medicine. This practice of ancient medicine besides shedding light on various possible theoretical modern day disorders serves as a vast resource for therapeutics...
July 28, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28746861/investigation-of-the-inhibitory-potential-of-phospholipase-a2-inhibitor-gamma-from-sinonatrix-annularis-to-snake-envenomation
#13
Shengwei Xiong, Yunyun Luo, Lipeng Zhong, Huixiang Xiao, Hong Pan, Keren Liao, Mengxue Yang, Chunhong Huang
SaPLIγ is a novel gamma phospholipase A2 inhibitor (PLI) recently isolated from Sinonatrix annularis, a Chinese endemic non-venomous snake. To explore the neutralization effects of saPLIγ in snakebite envenomation, a dose equivalent to LD50 of Deinagkistrodon acutus, Agkistrodon halys and Naja atra venom with/without saPLIγ was inoculated into the gastrocnemius muscle of female Kunming mice. The ability of saPLIγ to inhibit myonecrosis and systemic toxicity were evaluated through investigations of muscle histopathology, and determination of the serum levels of creatine kinase (CK), lactate dehydrogenase isoenzyme1 (LDH1) and aspartate transferase (AST)...
July 23, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28678411/cost-effectiveness-of-a-lifestyle-modification-program-in-long-term-survivors-of-haemopoietic-stem-cell-transplantation
#14
Lan Gao, Marj Moodie, Victoria Brown, Sharon Avery
To evaluate the cost-effectiveness of a lifestyle modification program targeting long-term survivors of haematological malignancy treated with haemopoietic stem cell transplantation, a multi-state life table Markov model was used to calculate health outcomes for both the intervention and no intervention. Cost per health-adjusted life year (HALY) saved was reported for four scenarios: all participants with/without standard weight regain, participants who at baseline were overweight with/without standard weight regain...
July 5, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28675985/hydrogen-alleviates-hyperoxic-acute-lung-injury-related-endoplasmic-reticulum-stress-in-rats-through-upregulation-of-sirt1
#15
Qiang Sun, Wenjie Han, Huijun Hu, Danfeng Fan, Yanbo Li, Yu Zhang, Yan Lv, Mingxin Li, Shuyi Pan
Hyperoxic acute lung injury (HALI) is a major clinical problem for patients undergoing supplemental oxygen therapy. Currently in clinical settings there exist no effective means of prevention or treatment methods. Our previous study found that: hydrogen could reduce HALI, as well as oxidative stress. This research will further explore the mechanism underlying the protective effect of hydrogen on oxygen toxicity. Rats were randomly assigned into three experimental groups and were exposed in a oxygen chamber for 60 continuous hours: 100% balanced air (control); 100% oxygen (HALI); 100% oxygen with hydrogen treatment (HALI + HRS)...
July 21, 2017: Free Radical Research
https://www.readbyqxmd.com/read/28657429/safety-profile-of-snake-antivenom-use-in-hong-kong-a-review-of-191-cases-from-2008-to-2015
#16
Rupeng Mong, Vember C H Ng, Man Li Tse
INTRODUCTION: The mainstay of treatment for significant envenoming from snakebites is antivenom. However, there is insufficient data regarding the safety of antivenom used in Hong Kong. We describe the incidence of hypersensitivity reactions from antivenom use and review the frequency and reasons for intensive care unit (ICU) admission. METHODS: The Hong Kong Poisons Information Centre database was reviewed. All patients given snake antivenom between 2008 and 2015 were included...
June 28, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28654688/modelled-health-benefits-of-a-sugar-sweetened-beverage-tax-across-different-socioeconomic-groups-in-australia-a-cost-effectiveness-and-equity-analysis
#17
Anita Lal, Ana Maria Mantilla-Herrera, Lennert Veerman, Kathryn Backholer, Gary Sacks, Marjory Moodie, Mohammad Siahpush, Rob Carter, Anna Peeters
BACKGROUND: A sugar-sweetened beverage (SSB) tax in Mexico has been effective in reducing consumption of SSBs, with larger decreases for low-income households. The health and financial effects across socioeconomic groups are important considerations for policy-makers. From a societal perspective, we assessed the potential cost-effectiveness, health gains, and financial impacts by socioeconomic position (SEP) of a 20% SSB tax for Australia. METHODS AND FINDINGS: Australia-specific price elasticities were used to predict decreases in SSB consumption for each Socio-Economic Indexes for Areas (SEIFA) quintile...
June 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28647256/bioavailability-of-wastewater-derived-dissolved-organic-nitrogen-to-green-microalgae-selenastrum-capricornutum-chlamydomonas-reinhardtii-and-chlorella-vulgaris-with-without-presence-of-bacteria
#18
Jingyi Sun, Halis Simsek
Effluent dissolved organic nitrogen (DON) is problematic in nutrient sensitive surface waters and needs to be reduced to meet demanding total dissolved nitrogen discharge limits. Bioavailable DON (ABDON) is a portion of DON utilized by algae or algae+bacteria, while biodegradable DON (BDON) is a portion of DON decomposable by bacteria. ABDON and BDON in a two-stage trickling filter (TF) wastewater treatment plant was evaluated using three different microalgal species, Selenastrum capricornutum, Chlamydomonas reinhardtii and Chlorella vulgaris and mixed cultured bacteria...
July 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/28632277/variable-temperature-and-high-pressure-crystal-chemistry-of-perovskite-formamidinium-lead-iodide-a-single-crystal-x-ray-diffraction-and-computational-study
#19
Shijing Sun, Zeyu Deng, Yue Wu, Fengxia Wei, Furkan Halis Isikgor, Federico Brivio, Michael W Gaultois, Jianyong Ouyang, Paul D Bristowe, Anthony K Cheetham, Gregor Kieslich
We investigate the variable temperature (100-450 K) and high-pressure (p = ambient - 0.74 GPa) crystal chemistry of the black perovskite formamidinium lead iodide, [(NH2)2CH]PbI3, using single crystal X-ray diffraction. In both cases we find a phase transition to a tetragonal phase. Our experimental results are combined with first principles calculations, providing information about the electronic properties of [(NH2)2CH]PbI3 as well as the most probable orientation of the [(NH2)2CH](+) cations.
July 4, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28627813/effect-of-the-oxidant-antioxidant-system-in-seminal-plasma-on-varicocele-and-idiopathic-infertility-in-male-humans
#20
Hayrullah Yazar, Fikret Halis, Yasemin Nasir, Derya Guzel, Mehmet Akdogan, Ahmet Gokce
BACKGROUND: The aim of this study was to investigate seminal oxidant-antioxidant activity in idiopathic and varicocele infertility in men. METHODS: Total anti-oxidant capacity (TAC), total oxidant status (TOS), paraoxonase (PON1), aryl esterase (ARE), and total thiol levels (TTL) were measured in seminal plasma with an autoanalyzer. The TOS/TAC ratio was determined as the oxidative stress index (OSI). A histopathological evaluation of the sperm was performed in the andrology laboratory of the hospital...
May 1, 2017: Clinical Laboratory
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