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Elif Oral Ahiskalioglu, Pelin Aydin, Ali Ahiskalioglu, Bahadir Suleyman, Ufuk Kuyrukluyildiz, Nezahat Kurt, Durdu Altuner, Resit Coskun, Halis Suleyman
Introduction: We compared the side effects of ketamine and thiopental used alone and of a ketamine/thiopental combination dose on the brain,heart, and bronchial tissues of rats. Material and methods: Three groups received intraperitoneal injections of 30 mg/kg ketamine (K-30); 15 mg/kg thiopental (T-15); or of both in combination (KTSA). These doses were doubled in another set of study groups (K-60, T-30, and KTA groups, respectively). Optimal anesthesia duration was examined in all groups...
April 2018: Archives of Medical Science: AMS
Vicki Brown, Jaithri Ananthapavan, Lennert Veerman, Gary Sacks, Anita Lal, Anna Peeters, Kathryn Backholer, Marjory Moodie
Television (TV) advertising of food and beverages high in fat, sugar and salt (HFSS) influences food preferences and consumption. Children from lower socioeconomic position (SEP) have higher exposure to TV advertising due to more time spent watching TV. This paper sought to estimate the cost-effectiveness of legislation to restrict HFSS TV advertising until 9:30 pm, and to examine how health benefits and healthcare cost-savings differ by SEP. Cost-effectiveness modelling was undertaken (i) at the population level, and (ii) by area-level SEP...
May 15, 2018: Nutrients
Ana Maria Mantilla Herrera, Michelle Crino, Holly E Erskine, Gary Sacks, Jaithri Ananthapavan, Cliona Ni Mhurchu, Yong Yi Lee
The Health Star Rating (HSR) system is a voluntary front-of-pack labelling (FoPL) initiative endorsed by the Australian government in 2014. This study examines the impact of the HSR system on pre-packaged food reformulation measured by changes in energy density between products with and without HSR. The cost-effectiveness of the HSR system was modelled using a proportional multi-state life table Markov model for the 2010 Australian population. We evaluated scenarios in which the HSR system was implemented on a voluntary and mandatory basis (i...
May 14, 2018: Nutrients
Theresa M Cira, Robert L Koch, Eric C Burkness, W D Hutchison, Robert C Venette
Diapause and cold tolerance can profoundly affect the distribution and activity of temperate insects. Halyomorpha halys (Stål) (Hemiptera: Pentatomidae), an alien invasive species from Asia, enters a winter dormancy in response to environmental cues. We investigated the nature of this dormancy and its effects on H. halys cold tolerance, as measured by supercooling points, lower lethal temperatures, and overwintering field mortality. Dormancy was induced by rearing individuals in the laboratory or under field conditions...
May 5, 2018: Environmental Entomology
Dilsa Mizrak Kaya, Bengi Ozturk, Pinar Kubilay, Handan Onur, Gungor Utkan, Filiz Cay Senler, Ali Alkan, Halis Yerlikaya, Elif B Koksoy, Ebru Karci, Ahmet Demirkazik, Hakan Akbulut, Fikri Icli
AIM: There are inconsistent results about the effects of vitamin D level on breast cancer prognosis. We aimed to investigate the effect of vitamin D levels on the prognosis of resectable breast cancer in a patient group with highly different clothing styles. PATIENTS/METHODS: A total of 186 breast cancer patients were enrolled in the study. RESULTS: Vitamin D level was sufficient, insufficient and deficient in 17.2, 52.2 and 30.6% of patients, respectively...
May 9, 2018: Future Oncology
Hali Morrison, Geetha Menon, Matthew P Larocque, Bob van Veelen, Yury Niatsetski, Ezekiel Weis, Ron S Sloboda
PURPOSE: To investigate the dose calculation accuracy of the Advanced Collapsed cone Engine (ACE) algorithm for ocular brachytherapy using a COMS plaque loaded with I-125 seeds for two heterogeneous patient tissue scenarios. METHODS: The Oncura model 6711 I-125 seed and 16 mm COMS plaque were added to a research version (v4.6) of the Oncentra® Brachy (OcB) treatment planning system (TPS) for dose calculations using ACE. Treatment plans were created for two heterogeneous cases: (i) a voxelized eye phantom comprising realistic eye materials and densities and (ii) a patient CT dataset with variable densities throughout the dataset...
May 4, 2018: Medical Physics
Yulu Tang, Miao Huang, Qiping Hu, Huayu Wu, Jiali Yao, Kejian Sun, Xiaolong Li
Blood clots produced by Snake-venom thrombin-like enzymes (SVTLEs) are cleared rapidly, that makes SVTLEs attractive as potential candidates for antithrombotic therapy. We isolated a SVTLE, agkihpin, from the venom of Gloydius halys Pallas. Agkihpin was confirmed to a single-chain TLE with molecular mass of 25.5 kD, pI of 7.43, optimal pH of 8.0 (hydrolyzing TAME), linked carbohydrate absent, and weak fibrinogen clotting activity. It also found that (1) G. Halys might be the latest species in SVTLEs phylogenetic tree; (2) different level of conservation was shown among the SVTLEs from the Viperidae snakes...
April 25, 2018: Chemistry & Biodiversity
Halie K Miller, Whittney N Burda, Ronan K Carroll, Lindsey N Shaw
Staphylococcus aureus possess three alternative σ factors, including a lone extracytoplasmic function σ factor, σS. Our group previously identified and characterized this element, mapping three sigS promoters, demonstrating its inducibility during stress and virulence inducing conditions, and demonstrating a role for this factor in disease causation. In the present study, we identify a fourth promoter of the sigS operon, termed P4, located in a unique position internal to the sigS coding region. Transcriptional profiling revealed that expression from P4 is dominant to the three upstream promoters, particularly upon exposure to chemical stressors that elicit DNA damage and disrupt cell wall stability; each of which have previously been shown to stimulate sigS expression...
April 24, 2018: FEMS Microbiology Letters
David M Lowenstein, Vaughn M Walton
Globally distributed nonnative insects thrive by having a generalist diet and persisting across large latitudinal gradients. Halyomorpha halys (Stål) (Hemiptera: Pentatomidae) is a cold-tolerant invasive species that enters reproductive diapause in temperate North American and European climates. While it can survive the acute effects of subzero (°C) temperatures, it is poorly understood how exposure to infrequent cold temperatures affects postdiapause survival and behavior. We studied the impacts of episodic cold shock at temperatures of -6 to -2 (°C) at the onset of H...
April 17, 2018: Journal of Economic Entomology
Aaron K Apawu, Stephanie M Curley, Angela R Dixon, Mirabela Hali, Moaz Sinan, Rod D Braun, James Castracane, Anthony T Cacace, Magnus Bergkvist, Avril Genene Holt
Fundamental challenges of targeting specific brain regions for treatment using pharmacotherapeutic nanoparticle (NP) carriers include circumventing the blood-brain-barrier (BBB) and tracking delivery. Angiopep-2 (AP2) has been shown to facilitate the transport of large macromolecules and synthetic nanoparticles across the BBB. Thus, conjugation of AP2 to an MS2 bacteriophage based NP should also permit transport across the BBB. We have fabricated and tested a novel MS2 capsid-based NP conjugated to the ligand AP2...
April 14, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
Nur Baykara, Halis Akalın, Mustafa Kemal Arslantaş, Volkan Hancı, Çiğdem Çağlayan, Ferda Kahveci, Kubilay Demirağ, Canan Baydemir, Necmettin Ünal
BACKGROUND: The prevalence and mortality of sepsis are largely unknown in Turkey, a country with high antibiotic resistance. A national, multicenter, point-prevalence study was conducted to determine the prevalence, causative microorganisms, and outcome of sepsis in intensive care units (ICUs) in Turkey. METHODS: A total of 132 ICUs from 94 hospitals participated. All patients (aged > 18 years) present at the participating ICUs or admitted for any duration within a 24-h period (08:00 on January 27, 2016 to 08:00 on January 28, 2016) were included...
April 16, 2018: Critical Care: the Official Journal of the Critical Care Forum
Ali A Zaied, Halis K Akturk, Richard W Joseph, Augustine S Lee
Nivolumab, a monoclonal antibody against programmed cell death-1 receptor, is increasingly used in advanced cancers. While nivolumab use enhances cancer therapy, it is associated with increased immune-related adverse events. We describe an elderly man who presented in ketoacidosis after receiving nivolumab for metastatic renal cell carcinoma. On presentation, he was hyperpneic and laboratory analyses showed hyperglycemia and anion-gapped metabolic acidosis consistent with diabetic ketoacidosis. No other precipitating factors, besides nivolumab, were identified...
2018: Endocrinology, Diabetes & Metabolism Case Reports
Xu Linglong, Wu Dijiong
Hemocoagulase Agkistrodon Halys Pallas, a well-established hemostatic agent used in China, has widespread applications in various conditions of bleeding and hemorrhages. Although it presents a low risk of vascular thrombosis, the agent can be easily tolerated and does not show any harmful effects, except allergy. However, long-term use of hemocoagulase may induce hypofibrinogenemia in some patients. Herein, we report 11 patients of prolonged administration of hemocoagulase Agkistrodon, with particular attention to the dynamic changes in their coagulation functions...
April 2018: Indian Journal of Hematology & Blood Transfusion
Rendi Ma, Hali Yuan, Jing An, Xiaoyun Hao, Hongbin Li
GDSL lipase (GLIP) plays a pivotal role in plant cell growth as a multifunctional hydrolytic enzyme. Herein, a cotton (Gossypium hirsutum L. cv Xuzhou 142) GDSL lipase gene (GhGLIP) was obtained from developing ovules and fibers. The GhGLIP cDNA contained an open reading frame (ORF) of 1,143 base pairs (bp) and encodes a putative polypeptide of 380 amino acid residues. Sequence alignment indicated that GhGLIP includes four enzyme catalytic amino acid residue sites of Ser (S), Gly (G), Asn (N) and His (H), located in four conserved blocks...
2018: PloS One
Waleed Abdullah Milaat, Nahla Khamis Ibrahim, Hussain Mohammed Albar
BACKGROUND: Improving the reproductive health of females has be.come the focus of the developmental efforts of many nations. OBJECTIVES: To identify the reproductive health style of married females, and to determine the prevalence and predictors of circumcision among girls aged less than or equal 18 years in Hali semi-urban region. DESIGN: A cross-sectional household survey SETTING: Houses in Hali, Al-Qunfudhah governorate, western Saudi Arabia during 2017...
March 2018: Annals of Saudi Medicine
Angelo Clemenzi-Allen, Elvin Geng, Katerina Christopoulos, Hali Hammer, Susan Buchbinder, Diane Havlir, Monica Gandhi
Housing instability negatively impacts outcomes in people [living] with human immunodeficiency virus (PLHIV), yet the effect of diverse living arrangements has not previously been evaluated. Using 6 dwelling types to measure housing status, we found a strong inverse association between housing instability and viral suppression across a spectrum of unstable housing arrangements.
March 2018: Open Forum Infectious Diseases
Brian I Carr, Hikmet Akkiz, Oguz Üsküdar, Kendal Yalçın, Vito Guerra, Sedef Kuran, Ümit Karaoğullarından, Engin Altıntaş, Ayşegül Özakyol, Salih Tokmak, Tuğsan Ballı, Mehmet Yücesoy, Halil İbrahim Bahçeci, Abdulalh Ülkü, Tolga Akçam, Kamil Yalçın Polat, Nazım Ekinci, Halis Şimşek, Necati Örmeci, Abdulalh Sonsuz, Mehmet Demir, Murat Kılıç, Ahmet Uygun, Ali Demir, Anıl Delik, Burcu Arslan, Figen Doran, Sezai Yilmaz, Yaman Tokat
A large database of 1773 HCC patients in Turkey was examined. 41.9% had alpha-fetoprotein (AFP) levels <20 IU/ml and an additional 16.123% had values between 20-100 IU/ml. This 58% of the cohort (<100 IU/ml AFP levels) was examined in detail. 66% of patients with small (<5 cm) HCCs had low AFP, compared to 49% of patients with larger (>5 cm) HCCs. The mean diameter (MTD) of larger MTD, low AFP tumors was 8.4cm. Therefore, factors other than AFP must contribute to HCC tumor growth. Larger tumors in low AFP patients had both higher platelet levels and increased PVT percent...
2018: Clinical Practice
Halis Özdemir, Hakan Kalaycı, Selçuk Yetkinel, Tayfun Çok, Gonca Çoban, Ebru Tarım
AIM: We aimed to define the normal values of second-trimester fetal prenasal thickness and nasal bone length ratio (PNT/NBL) in a low-risk Turkish population and investigate the relationship between the increased PNT and nuchal fold (NF). METHOD: We retrospectively reviewed the data of 650 cases considered to be euploid fetuses who presented to our clinic between December 2013 and September 2014 for a second-line ultrasound between 17 and 24 weeks. Their PNT, NBL, NF and biometric (BPD, HC, AC, FL and HL) measurements were recorded...
March 23, 2018: Journal of Obstetrics and Gynaecology Research
Khaled Abu El Aish, Raed Tafish, Haly Zourob
BACKGROUND: Finding appropriate analgesics is important for a mother's recovery after a caesarean section. The aim of this study was to compare the analgesic effect of spinal morphine and fentanyl for women undergoing a caesarean section. METHODS: In this randomised, unmasked, parallel-group, controlled trial, eligible participants were women undergoing caesarean section with spinal anaesthetic at the Al-Helal Al-Emirati Hospital, Rafah, Gaza Strip, occupied Palestinian territory...
February 21, 2018: Lancet
Amir Koolivand, Stephan Clayton, Halie Rion, Armin Oloumi, Ariel O'Brien, Morteza G Khaledi
As previously reported, fluoroalcohols can induce coacervation in aqueous solutions of amphiphilic compounds with subsequent formation of two-phase systems, where one phase is enriched in amphiphile and fluoroalcohol and the other is primarily an aqueous - rich phase. This study focuses on the use of simple coacervates made of a single component amphiphile induced by a fluoroalcohol for extraction and enrichment of proteins. 1,1,1,3,3,3-Hexafluoroisopropanol (HFIP) and 2,2,2-trifluoroethanol (TFE) were used to induce coacervation in the aqueous solutions of a cationic amphiphile, cetyltrimethylammonium bromide (CTAB) or tetra-n-butylammonium bromide (TBAB)...
March 3, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
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