keyword
MENU ▼
Read by QxMD icon Read
search

Egr

keyword
https://www.readbyqxmd.com/read/29601855/egr-1-expression-in-catecholamine-synthesizing-neurons-reflects-auditory-learning-and-correlates-with-responses-in-auditory-processing-areas
#1
Jennifer B Dai, Yining Chen, Jon T Sakata
Distinguishing between familiar and unfamiliar individuals is an important task that shapes the expression of social behavior. As such, identifying the neural populations involved in processing and learning the sensory attributes of individuals is important for understanding mechanisms of behavior. Catecholamine-synthesizing neurons have been implicated in sensory processing, but relatively little is known about their contribution to auditory learning and processing across various vertebrate taxa. Here we investigated the extent to which immediate early gene expression in catecholaminergic circuitry reflects information about the familiarity of social signals and predicts immediate early gene expression in sensory processing areas in songbirds...
March 27, 2018: Neuroscience
https://www.readbyqxmd.com/read/29579710/bu-shen-zhu-yun-decoction-promotes-synthesis-and-secretion-of-fsh%C3%AE-and-lh%C3%AE-in-anterior-pituitary-cells-in-vitro
#2
Xiaofei Jiang, Huifang Zhou, Mingqing Shi, Boru Zhou, Bei Liu, Yizhen Yuan, Jinjun Shan, Jianya Xu, Tong Xie
Luteal phase defects (LPD) are an important etiology of infertility which has increased in recent years. Studies have shown that bu-shen-zhu-yun decoction (BSZY-D) can lower the expression of estrogen receptor and progesterone receptor, in rats endometrium of embryonic implantation period, which upregulated by mifepristone, and improve uterine receptivity. The aim of present study was to determine the effect of BSZY-D on the synthesis and secretion of gonadotropic hormones in the anterior pituitary cells of rats...
March 23, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29563122/epigenetic-programming-of-t-cells-impacts-immune-reconstitution-in-hematopoietic-stem-cell-transplant-recipients
#3
Kristine Hardy, Corey Smith, Wen Juan Tu, Robert McCuaig, Archana Panikkar, Vijayendra Dasari, Fan Wu, Siok-Keen Tey, Geoffrey R Hill, Rajiv Khanna, Sudha Rao
Immune reconstitution following hematopoietic stem cell transplantation (HSCT) is critical in preventing harmful sequelae in recipients with cytomegalovirus (CMV) infection. To understand the molecular mechanisms underlying immune reconstitution kinetics, we profiled the transcriptome-chromatin accessibility landscape of CMV-specific CD8+ T cells from HCST recipients with different immune reconstitution efficiencies. CMV-specific T cells from HSCT recipients with stable antiviral immunity expressed higher levels of interferon/defense response and cell cycle genes in an interconnected network involving PI3KCG , STAT5B , NFAT , RBPJ , and lower HDAC6 , increasing chromatin accessibility at the enhancer regions of immune and T-cell receptor signaling pathway genes...
March 27, 2018: Blood Advances
https://www.readbyqxmd.com/read/29561772/the-host-factor-early-growth-response-gene-egr-1-regulates-vaccinia-virus-infectivity-during-infection-of-starved-mouse-cells
#4
Leonardo C de Oliveira, Bruno S A F Brasil, Bethany Unger, Giliane S Trindade, Jonatas S Abrahão, Erna G Kroon, Paula Traktman, Cláudio A Bonjardim
Evolution has equipped poxvirus genomes with the coding capacity for several virus-host interaction products which interfere with host cell gene expression and protein function, creating an adequate intracellular environment for a productive infection. We show here that Vaccinia virus (VACV) induces the expression of the cellular transcription factor EGR-1 (early growth response-1) in Mouse Embryonic Fibroblasts (MEFs) through the MEK (mitogen-activated protein kinase (MAPK)/ERK)/ERK (extracellular signal-regulated kinases) pathway, from 3 to 12 h post infection (h...
March 21, 2018: Viruses
https://www.readbyqxmd.com/read/29550088/update-in-the-percutaneous-management-of-coronary-chronic-total-occlusions
#5
REVIEW
Peter Tajti, M Nicholas Burke, Dimitri Karmpaliotis, Khaldoon Alaswad, Gerald S Werner, Lorenzo Azzalini, Mauro Carlino, Mitul Patel, Kambis Mashayekhi, Mohaned Egred, Oleg Krestyaninov, Dmitrii Khelimskii, William J Nicholson, Imre Ungi, Alfredo R Galassi, Subhash Banerjee, Emmanouil S Brilakis
Percutaneous coronary intervention (PCI) for chronic total occlusions (CTOs) has been rapidly evolving during recent years. With improvement in equipment and techniques, high success rates can be achieved at experienced centers, although overall success rates remain low. Prospective, randomized-controlled data regarding optimal use and indications for CTO PCI remain limited. CTO PCI should be performed when the anticipated benefit exceeds the potential risk. New high-quality studies of the clinical outcomes and techniques of CTO PCI are needed, as is the expansion of expert centers and operators that can achieve excellent clinical outcomes in this challenging patient and lesion subgroup...
March 12, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29543533/early-growth-response-1-negative-feedback-regulates-skeletal-muscle-postprandial-insulin-sensitivity-via-activating-ptp1b-transcription
#6
Jing Wu, Wei-Wei Tao, Dan-Yang Chong, Shan-Shan Lai, Chuang Wang, Qi Liu, Tong-Yu Zhang, Bin Xue, Chao-Jun Li
Postprandial insulin desensitization plays a critical role in maintaining whole-body glucose homeostasis by avoiding the excessive absorption of blood glucose; however, the detailed mechanisms that underlie how the major player, skeletal muscle, desensitizes insulin action remain to be elucidated. Herein, we report that early growth response gene-1 ( Egr-1) is activated by insulin in skeletal muscle and provides feedback inhibition that regulates insulin sensitivity after a meal. The inhibition of the transcriptional activity of Egr-1 enhanced the phosphorylation of the insulin receptor (InsR) and Akt, thus increasing glucose uptake in L6 myotubes after insulin stimulation, whereas overexpression of Egr-1 decreased insulin sensitivity...
March 15, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29535721/early-growth-response-gene-2-expressing-cd4-lag3-regulatory-t-cells-the-therapeutic-potential-for-treating-autoimmune-diseases
#7
REVIEW
Tomohisa Okamura, Kazuhiko Yamamoto, Keishi Fujio
Regulatory T cells (Tregs) are necessary for the maintenance of immune tolerance. Tregs are divided into two major populations: one is thymus derived and the other develops in the periphery. Among these Tregs, CD4+ CD25+ Tregs, which mainly originate in the thymus, have been extensively studied. Transcription factor Foxp3 is well known as a master regulatory gene for the development and function of CD4+ CD25+ Tregs. On the other hand, peripheral Tregs consist of distinct cell subsets including Foxp3-dependent extrathymically developed Tregs and interleukin (IL)-10-producing type I regulatory T (Tr1) cells...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29520222/immediate-early-genes-anchor-a-biological-pathway-of-proteins-required-for-memory-formation-long-term-depression-and-risk-for-schizophrenia
#8
Ketan K Marballi, Amelia L Gallitano
While the causes of myriad medical and infectious illnesses have been identified, the etiologies of neuropsychiatric illnesses remain elusive. This is due to two major obstacles. First, the risk for neuropsychiatric disorders, such as schizophrenia, is determined by both genetic and environmental factors. Second, numerous genes influence susceptibility for these illnesses. Genome-wide association studies have identified at least 108 genomic loci for schizophrenia, and more are expected to be published shortly...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29520172/fluvastatin-inhibits-advanced-glycation-end-products-induced-proliferation-migration-and-extracellular-matrix-accumulation-in-vascular-smooth-muscle-cells-by-targeting-connective-tissue-growth-factor
#9
Ae-Rang Hwang, Ju-Ock Nam, Young Jin Kang
Connective tissue growth factor (CTGF) is a novel fibrotic mediator, which is considered to mediate fibrosis through extracellular matrix (ECM) synthesis in diabetic cardiovascular complications. Statins have significant immunomodulatory effects and reduce vascular injury. We therefore examined whether fluvastatin has anti-fibrotic effects in vascular smooth muscle cells (VSMCs) and elucidated its putative transduction signals. We show that advanced glycation end products (AGEs) stimulated CTGF mRNA and protein expression in a time-dependent manner...
March 2018: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29518540/regulation-of-the-voltage-gated-ca-2-channel-ca-v-%C3%AE-2-%C3%AE-1-subunit-expression-by-the-transcription-factor-egr-1
#10
Ricardo González-Ramírez, Elizabeth Martínez-Hernández, Alejandro Sandoval, Kimberly Gómez-Mora, Ricardo Felix
It is well known that the CaV α2 δ auxiliary subunit regulates the density of high voltage-activated Ca2+ channels in the plasma membrane and that alterations in their functional expression might have implications in the pathophysiology of diverse human diseases such as neuropathic pain. However, little is known concerning the transcriptional regulation of this protein. We previously characterized the promoter of CaV α2 δ, and here we report its regulation by the transcription factor Egr-1. Using the neuroblastoma N1E-115 cells, we found that Egr-1 interacts specifically with its binding site in the promoter, affecting the transcriptional regulation of CaV α2 δ...
March 5, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29516510/integrated-analysis-of-long-noncoding-rna-associated-competing-endogenous-rna-network-in-periodontitis
#11
S Li, X Liu, H Li, H Pan, A Acharya, Y Deng, Y Yu, R Haak, J Schmidt, G Schmalz, D Ziebolz
BACKGROUND AND OBJECTIVES: Long noncoding RNAs (lncRNAs) play critical and complex roles in regulating various biological processes of periodontitis. This bioinformatic study aims to construct a putative competing endogenous RNA (ceRNA) network by integrating lncRNA, miRNA and mRNA expression, based on high-throughput RNA sequencing and microarray data about periodontitis. MATERIAL AND METHODS: Data from 1 miRNA and 3 mRNA expression profiles were obtained to construct the lncRNA-associated ceRNA network...
March 8, 2018: Journal of Periodontal Research
https://www.readbyqxmd.com/read/29513566/reactive-oxygen-species-up-regulate-expression-of-muscle-atrophy-associated-ubiquitin-ligase-cbl-b-in-rat-l6-skeletal-muscle-cells
#12
Takayuki Uchida, Yoshihiro Sakashita, Kanako Kitahata, Yui Yamashita, Chisato Tomida, Yuki Kimori, Akio Komatsu, Katsuya Hirasaka, Ayako Ohno, Reiko Nakao, Atsushi Higashitani, Akira Higashibata, Noriaki Ishioka, Toru Shimazu, Takeshi Kobayashi, Yuushi Okumura, Inho Choi, Motoko Oarada, Edward M Mills, Shigetada Teshima-Kondo, Shin'ichi Takeda, Eiji Tanaka, Keiji Tanaka, Masahiro Sokabe, Takeshi Nikawa
Unloading-mediated muscle atrophy is associated with increased reactive oxygen species (ROS) production. We previously demonstrated that elevated ubiquitin ligase casitas B-lineage lymphoma-b (Cbl-b) resulted in the loss of muscle volume [Nakao R. et al. Mol Cell Biol, 29: 4798-4811, 2009]. However, the pathological role of ROS production associated with unloading-mediated muscle atrophy still remains unknown. Here, we showed the ROS-mediated signal transduction caused by microgravity or its simulation contributes to Cbl-b expression...
March 7, 2018: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/29510201/rat-inferior-caval-vein-icv-ligature-and-particular-new-insights-with-the-stable-gastric-pentadecapeptide-bpc-157
#13
Jaksa Vukojevic, Marko Siroglavic, Katarina Kasnik, Tamara Kralj, Duje Stancic, Antonio Kokot, Darko Kolaric, Domagoj Drmic, Anita Zenko Sever, Ivan Barisic, Jelena Suran, Davor Bojic, Masa Hrelec Patrlj, Ivica Sjekavica, Katarina Horvat Pavlov, Tinka Vidovic, Josipa Vlainic, Mirjana Stupnisek, Sven Seiwerth, Predrag Sikiric
Rat inferior caval vein (ICV) ligation (up to the right ovarian vein (ROV)) commonly represents a recapitulation of Virchow: with ligation leading to vessel injury, stasis, thrombosis and hemodynamic changes. We revealed that BPC 157's therapy collectively attenuated or counteracted all these events and the full syndrome. METHODS: We applied BPC 157 (10 μg, 10 ng/kg) as an early regimen or as a delayed therapy. Assessment includes gross assessment by microcamera; microscopy, venography, bleeding, blood pressure, ECG, thermography, MDA and NO-level in plasma and ICV, and gene expression...
March 3, 2018: Vascular Pharmacology
https://www.readbyqxmd.com/read/29497945/cleaner-emissions-from-a-di-diesel-engine-fueled-with-waste-plastic-oil-derived-from-municipal-solid-waste-under-the-influence-of-n-pentanol-addition-cold-egr-and-injection-timing
#14
Dillikannan Damodharan, Amudhavalli Paramasivam Sathiyagnanam, Babu Rajesh Kumar, Kuttalam Chidambaradhanu Ganesh
Urban planning and development is a decisive factor that increases the automobile numbers which leads to increased energy demand across the globe. In order to meet the escalating requirements of energy, it is necessary to find viable alternatives. Waste plastic oil (WPO) is one such alternative which has dual benefits as it reduces the environmental pollution caused by plastic waste and it could possibly meet the energy requirement along with fossil fuels. The study attempted to reduce emissions from a DI diesel engine fueled with WPO using 30% by volume of n-pentanol with fossil diesel (WPO70P30)...
March 1, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29496477/activation-of-immediate-early-genes-by-nicotine-after-chronic-neonatal-nicotine-exposure-in-brain-areas-involved-in-stress-and-anxiety-responses
#15
Amal A Halawa, Joanne C Damborsky, G Simona Slaton, Ursula H Winzer-Serhan
Maternal smoking has negative long-term consequences on affective behaviors, and in rodents, chronic neonatal nicotine exposure (CNN) results in increased anxiety. In rat pups, acute nicotine stimulation activates brain regions associated with stress and anxiety, but chronic nicotine exposure could desensitize of nicotinic acetylcholine receptors, the molecular target of nicotine. Here, we determined whether CNN affected neuronal activation by an acute nicotine challenge. Using in situ hybridization, we analyzed mRNA expression of the immediate-early genes (IEGs) c-Fos, Arc, Egr-1 and Npas4, which are markers for neuronal activation and implicated in synaptic plasticity...
February 26, 2018: Brain Research
https://www.readbyqxmd.com/read/29490938/lipoxins-regulate-the-early-growth-response-1-network-and-reverse-diabetic-kidney-disease
#16
Eoin P Brennan, Muthukumar Mohan, Aaron McClelland, Christos Tikellis, Mark Ziemann, Antony Kaspi, Stephen P Gray, Raelene Pickering, Sih Min Tan, Syed Tasadaque Ali-Shah, Patrick J Guiry, Assam El-Osta, Karin Jandeleit-Dahm, Mark E Cooper, Catherine Godson, Phillip Kantharidis
Background The failure of spontaneous resolution underlies chronic inflammatory conditions, including microvascular complications of diabetes such as diabetic kidney disease. The identification of endogenously generated molecules that promote the physiologic resolution of inflammation suggests that these bioactions may have therapeutic potential in the context of chronic inflammation. Lipoxins (LXs) are lipid mediators that promote the resolution of inflammation. Methods We investigated the potential of LXA4 and a synthetic LX analog (Benzo-LXA4 ) as therapeutics in a murine model of diabetic kidney disease, ApoE-/- mice treated with streptozotocin...
February 28, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29486207/nachrs-erk1-2-egr-1-signaling-participates-in-the-developmental-toxicity-of-nicotine-by-epigenetically-down-regulating-placental-11%C3%AE-hsd2
#17
Jin Zhou, Fulin Liu, Luting Yu, Dan Xu, Bin Li, Guohui Zhang, Wen Huang, Lu Li, Yuanzhen Zhang, Wei Zhang, Hui Wang
Impaired placental 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) activity which inactivates maternal glucocorticoids is associated with poor fetal growth and a higher risk of chronic diseases in adulthood. This study aimed to elucidate the epigenetically regulatory mechanism of nicotine on placental 11β-HSD2 expression. Pregnant Wistar rats were administered 1.0 mg/kg nicotine subcutaneously twice a day from gestational day 9 to 20. The results showed that prenatal nicotine exposure increased corticosterone levels in the placenta and fetal serum, disrupted placental morphology and endocrine function, and reduced fetal bodyweight...
February 24, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29481791/egr-1-mediated-cardiac-mir-99-family-expression-diverges-physiological-hypertrophy-from-pathological-hypertrophy
#18
Subbiah Ramasamy, Ganesan Velmurugan, Balakrishnan Rekha, Sivakumar Anusha, K Shanmugha Rajan, Suresh Shanmugarajan, Tharmarajan Ramprasath, Pandi Gopal, Dhanendra Tomar, Karuppusamy V Karthik, Suresh Kumar Verma, Venkata Naga Srikanth Garikipati, Rajan Sudarsan
The physiological cardiac hypertrophy is an adaptive condition without myocyte cell death, while pathological hypertrophy is a maladaptive condition associated with myocyte cell death. This study explores the miRNome of α-2M-induced physiologically hypertrophied cardiomyocytes and the role of miRNA-99 family during cardiac hypertrophy. Physiological and pathological cardiac hypertrophy was induced in H9c2 cardiomyoblast cell lines using α-2M and isoproterenol respectively. Total RNA isolation and small RNA sequencing were executed for physiological hypertrophy model...
February 23, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29468740/neuroprotective-effects-of-20-s-protopanaxatriol-ppt-on-scopolamine-induced-cognitive-deficits-in-mice
#19
Cong Lu, Jingwei Lv, Liming Dong, Ning Jiang, Yan Wang, Qiong Wang, Yinghui Li, Shanguang Chen, Bei Fan, Fengzhong Wang, Xinmin Liu
20(S)-protopanaxatriol (PPT), one of the ginsenosides from Panax ginseng, has been reported to have neuroprotective effects and to improve memory. The present study was designed to investigate the protective effect of PPT on scopolamine-induced cognitive deficits in mice. Male Institute of Cancer Research mice were pretreated with 2 different doses of PPT (20 and 40 μmol/kg) for 27 days by intraperitoneal injection, and scopolamine (0.75 mg/kg) was injected intraperitoneally for 9 days to induce memory impairment...
February 22, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29468394/emission-and-performance-analysis-on-the-effect-of-exhaust-gas-recirculation-in-alcohol-biodiesel-aspirated-research-diesel-engine
#20
Arulprakasajothi Mahalingam, Dinesh Babu Munuswamy, Yuvarajan Devarajan, Santhanakrishnan Radhakrishnan
In this study, the effect of blending pentanol to biodiesel derived from mahua oil on emissions and performance pattern of a diesel engine under exhaust gas recirculation (EGR) mode was examined and compared with diesel. The purpose of this study is to improve the feasibility of employing biofuels as a potential alternative in an unmodified diesel engine. Two pentanol-biodiesel blends denoted as MOBD90P10 and MOBD80P20 which matches to 10 and 20 vol% of pentanol in biodiesel, respectively, were used as fuel in research engine at 10 and 20% EGR rates...
February 21, 2018: Environmental Science and Pollution Research International
keyword
keyword
41183
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"