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https://www.readbyqxmd.com/read/28076410/role-for-egr1-in-the-transcriptional-program-associated-with-neuronal-differentiation-of-pc12-cells
#1
Kenneth W Adams, Sergey Kletsov, Ryan J Lamm, Jessica S Elman, Steven Mullenbrock, Geoffrey M Cooper
PC12 cells are a well-established model to study how differences in signal transduction duration can elicit distinct cell behaviors. Epidermal growth factor (EGF) activates transient ERK signaling in PC12 cells that lasts 30-60 min, which in turn promotes proliferation; nerve growth factor (NGF) activates more sustained ERK signaling that lasts 4-6 h, which in turns induces neuronal differentiation. Data presented here extend a previous study by Mullenbrock et al. (2011) that demonstrated that sustained ERK signaling in response to NGF induces preferential expression of a 69-member gene set compared to transient ERK signaling in response to EGF and that the transcription factors AP-1 and CREB play a major role in the preferential expression of several genes within the set...
2017: PloS One
https://www.readbyqxmd.com/read/28068629/stars-knockout-attenuates-hypoxia-induced-pulmonary-arterial-hypertension-by-suppressing-pulmonary-arterial-smooth-muscle-cell-proliferation
#2
Zhaoling Shi, Huajie Wu, Jianfeng Luo, Xin Sun
STARS (STriated muscle Activator of Rho Signaling) is a sarcomeric protein, which expressed early in cardiac development and involved in pathological remodeling. Abundant evidence indicated that STARS could regulate cell proliferation, but it's exact function remains unclear. In this study, we aimed to investigate the role of STARS in the proliferation of pulmonary arterial smooth muscle cells (PASMC) and the potential effect on the progression of pulmonary arterial hypertension (PAH). In this study, we established a PAH mouse model through chronic hypoxia exposure as reflected by the increased RVSP and RVHI...
January 6, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28062363/governing-roles-for-trib3-pseudokinase-during-stress-erythropoiesis
#3
Arvind Dev, Ruth Asch, Edward Jachimowicz, Nicole Rainville, Ashley Johnson, Emily Greenfest-Allen, Don M Wojchowski
In response to anemia, the heightened production of erythropoietin (EPO) can sharply promote erythroid progenitor cell (EPC) formation. Specific mediators of such EPO- accelerated erythropoiesis, however, are not well understood. Presently, we first report that the expression of Trib3 in adult bone marrow EPCs in vivo is nominal at steady state, but strongly activated upon EPO challenge. In a knockout mouse model, Trib3 disruption modestly decreased steady-state erythrocyte numbers, and increased mean corpuscular volume...
January 3, 2017: Experimental Hematology
https://www.readbyqxmd.com/read/28053299/the-potential-role-of-elk-3-egr-1-signaling-pathway-in-the-epithelial-mesenchymal-transition-during-liver-fibrosis
#4
EDITORIAL
In Hee Kim
No abstract text is available yet for this article.
January 15, 2017: Gut and Liver
https://www.readbyqxmd.com/read/28051865/evolution-of-in-cylinder-diesel-engine-soot-and-emission-characteristics-investigated-with-on-line-aerosol-mass-spectrometry
#5
Vilhelm Berg Malmborg, Axel Christian Eriksson, Mengqin Shen, Patrik Nilsson, Yann Gallo, Björn Waldheim, Johan Martinsson, Oivind Andersson, Joakim Pagels
To design diesel engines with low environmental impact, it is important to link health and climate-relevant soot (black carbon) emission characteristics to specific combustion conditions. The in-cylinder evolution of soot properties over the combustion cycle and as a function of exhaust gas recirculation (EGR) was investigated in a modern heavy-duty diesel engine. A novel combination of a fast gas-sampling valve and a soot particle aerosol mass spectrometer (SP-AMS) enabled on-line measurements of the in-cylinder soot chemistry...
January 4, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28045122/mirsig-a-consensus-based-network-inference-methodology-to-identify-pan-cancer-mirna-mirna-interaction-signatures
#6
Joseph J Nalluri, Debmalya Barh, Vasco Azevedo, Preetam Ghosh
Decoding the patterns of miRNA regulation in diseases are important to properly realize its potential in diagnostic, prog- nostic, and therapeutic applications. Only a handful of studies computationally predict possible miRNA-miRNA interactions; hence, such interactions require a thorough investigation to understand their role in disease progression. In this paper, we design a novel computational pipeline to predict the common signature/core sets of miRNA-miRNA interactions for different diseases using network inference algorithms on the miRNA-disease expression profiles; the individual predictions of these algorithms were then merged using a consensus-based approach to predict miRNA-miRNA associations...
January 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28044018/interindividual-variability-in-auditory-scene-analysis-revealed-by-confidence-judgements
#7
C Pelofi, V de Gardelle, P Egré, D Pressnitzer
Because musicians are trained to discern sounds within complex acoustic scenes, such as an orchestra playing, it has been hypothesized that musicianship improves general auditory scene analysis abilities. Here, we compared musicians and non-musicians in a behavioural paradigm using ambiguous stimuli, combining performance, reaction times and confidence measures. We used 'Shepard tones', for which listeners may report either an upward or a downward pitch shift for the same ambiguous tone pair. Musicians and non-musicians performed similarly on the pitch-shift direction task...
February 19, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28013468/performance-and-emission-analysis-on-blends-of-diesel-restaurant-yellow-grease-and-n-pentanol-in-direct-injection-diesel-engine
#8
J Ravikumar, S Saravanan
Yellow grease from restaurants is typically waste cooking oil (WCO) free from suspended food particles with free fatty acid (FFA) content less than 15%. This study proposes an approach to formulate a renewable, eco-friendly fuel by recycling WCO with diesel (D) and n-pentanol (P) to improve fuel-spray characteristics. Three ternary blends (D50-WCO45-P5, D50-WCO40-P10 and D50-WCO30-P20) were selected based on the stability tests and prepared with an objective to substitute diesel by 50% with up to 45% recycled component (WCO) and up to 20% bio-component (n-pentanol) by volume...
December 24, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28012964/resveratrol-regulates-gene-transcription-via-activation-of-stimulus-responsive-transcription-factors
#9
REVIEW
Gerald Thiel, Oliver G Rössler
Resveratrol (trans-3,4',5-trihydroxystilbene), a polyphenolic phytoalexin of grapes and other fruits and plants, is a common constituent of our diet and of dietary supplements. Many health-promoting benefits have been connected with resveratrol in the treatment of cardiovascular diseases, cancer, diabetes, inflammation, neurodegeneration, and diseases connected with aging. To explain the pleiotropic effects of resveratrol, the molecular targets of this compound have to be identified on the cellular level. Resveratrol induces intracellular signal transduction pathways which ultimately lead to changes in the gene expression pattern of the cells...
December 21, 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28011693/protein-phosphatase-2cs-and-microtubule-associated-stress-protein-1-control-microtubule-stability-plant-growth-and-drought-response
#10
Govinal Badiger Bhaskara, Tuan-Nan Wen, Thao Thi Nguyen, Paul E Verslues
Plant growth is coordinated with environmental factors, including water availability during times of drought. Microtubules influence cell expansion; however, the mechanisms by which environmental signals impinge upon microtubule organization and whether microtubule-related factors limit growth during drought remains unclear. We found that three Clade E Growth-Regulating (EGR) type 2 C protein phosphatases act as negative growth regulators to restrain growth during drought. Quantitative phosphoproteomics indicated that EGRs target cytoskeleton and plasma membrane-associated proteins...
December 23, 2016: Plant Cell
https://www.readbyqxmd.com/read/28002932/expression-of-egr3-in-mouse-gonads-and-its-localization-and-function-in-oocytes
#11
Hyejin Shin, Dong-Won Seol, Minyeong Nam, Haengseok Song, Dong Ryul Lee, Hyunjung Jade Lim
Objective: The early growth response (Egr) family consists of four members (Egr1, Egr2, Egr3, and Egr4) that are zinc finger transcription factors. Among them, Egr3 is involved in transcriptional regulation of target genes during muscle spindle formation and neurite outgrowth. We previously showed that the immunoreactive Egr3 is localized on oocyte spindle and accumulate near the microtubule organizing center (MTOC) during meiosis I in mice. Egr3 was also shown to be localized on spermatocytes...
December 17, 2016: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/27984699/gene-expression-correlated-to-severe-asthma-characteristics-reveals-heterogeneous-mechanisms-of-severe-disease
#12
Brian D Modena, Eugene R Bleecker, William W Busse, Serpil C Erzurum, Benjamin M Gaston, Nizar N Jarjour, Deborah A Meyers, Jadranka Milosevic, John R Tedrow, Wei Wu, Naftali Kaminski, Sally E Wenzel
RATIONALE: Severe asthma is a heterogeneous disease with multiple molecular mechanisms. Gene expression studies of asthmatic bronchial epithelial cells have provided biological insight and underscored possible mechanistic differences between individuals. OBJECTIVE: Identify networks of genes reflective of underlying biological processes that define severe asthma(SA). METHODS: Airway epithelial cell gene expression from 155 asthmatics and healthy controls(HC) in the Severe Asthma Research Program was analyzed by weighted gene co-expression network analysis (WGCNA) to identify gene networks and profiles associated with severe asthma and its specific characteristics (i...
December 16, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27970333/tct-164-pressure-controlled-intermittent-coronary-sinus-occlusion-reduces-infarct-size-and-results-in-functional-recovery-after-stemi-interim-analysis-of-an-ongoing-trial
#13
Mohaned Egred, Alan Bagnall, Ioakim Spyridopoulos, Ian Purcell, Rajiv Das, Nick Palmer, Ever Grech, Ajay Jain, Gregg Stone, Robin Nijveldt, Roger Kessels, Azfar Zaman
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27935858/paradoxical-induction-of-growth-arrest-and-apoptosis-by-egf-via-the-up-regulation-of-pten-by-activating-redox-factor-1-egr-1-in-human-lung-cancer-cells
#14
Je-Won Ryu, Sung Sik Choe, Seung-Hee Ryu, Eun-Young Park, Byoung Wook Lee, Tae Keun Kim, Chang Hoon Ha, Sang-Wook Lee
Epidermal growth factor (EGF) signaling promotes cell proliferation and survival in several types of cancer. Here, however, we showed that EGF inhibits proliferation and promotes programmed cell death in non-small cell lung cancer (NSCLC) cells. In A549 cells, EGF increased redox factor-1 (Ref-1) expression and the association of Ref-1 with zinc finger-containing transcriptional regulator (EGR1) via activation of p22phox, RAC1, and an NADPH oxidase subunit. EGF increased p22phox and RAC1 expression through activation of purinergic receptors (P2Y)...
December 7, 2016: Oncotarget
https://www.readbyqxmd.com/read/27933778/thermodynamic-additivity-for-impacts-of-base-pair-substitutions-on-association-of-the-egr-1-zinc-finger-protein-with-dna
#15
Abhijnan Chattopadhyay, Levani Zandarashvili, Ross H Luu, Junji Iwahara
The transcription factor Egr-1 specifically binds as a monomer to its 9 bp target DNA sequence, GCGTGGGCG, via three zinc fingers and plays important roles in the brain and cardiovascular systems. Using fluorescence-based competitive binding assays, we systematically analyzed the impacts of all possible single-nucleotide substitutions in the target DNA sequence and determined the change in binding free energy for each. Then, we measured the changes in binding free energy for sequences with multiple substitutions and compared them with the sum of the changes in binding free energy for each constituent single substitution...
November 29, 2016: Biochemistry
https://www.readbyqxmd.com/read/27923460/comparison-of-characteristics-and-complications-in-men-versus-women-undergoing-chronic-total-occlusion-percutaneous-intervention
#16
Vinoda Sharma, William Wilson, William Smith, Margaret McEntegart, Keith Oldroyd, Novalia Sidik, Alan Bagnall, Mohaned Egred, John Irving, Julian Strange, Thomas Johnson, Simon Walsh, Colm Hanratty, James Spratt
Gender differences exist in clinical outcomes after routine percutaneous coronary intervention (PCI), but studies reporting such outcomes after chronic total occlusion (CTO) PCI are limited. We assessed the characteristics and outcomes of female patients undergoing CTO PCI. We retrospectively analyzed a dedicated national (United Kingdom) prospective CTO database from 2011 to 2015 for outcomes and characteristics of female patients undergoing CTO PCI (unmatched and propensity matched). Female patients constituted 20...
November 16, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27914009/serum-response-factor-srf-ablation-interferes-with-acute-stress-associated-immediate-and-long-term-coping-mechanisms
#17
Annemarie Zimprich, Gabi Mroz, Christopher Meyer Zu Reckendorf, Sofia Anastasiadou, Philip Förstner, Lillian Garrett, Sabine M Hölter, Lore Becker, Jan Rozman, Cornelia Prehn, Birgit Rathkolb, Kristin Moreth, Wolfgang Wurst, Thomas Klopstock, Martin Klingenspor, Jerzy Adamski, Eckhard Wolf, Raffi Bekeredjian, Helmut Fuchs, Valerie Gailus-Durner, Martin Hrabe de Angelis, Bernd Knöll
Stress experience modulates behavior, metabolism, and energy expenditure of organisms. One molecular hallmark of an acute stress response is a rapid induction of immediate early genes (IEGs) such as c-Fos and Egr family members. IEG transcription in neurons is mediated by the neuronal activity-driven gene regulator serum response factor (SRF). We show a first role of SRF in immediate and long-lasting acute restraint stress (AS) responses. For this, we employed a standardized mouse phenotyping protocol at the German Mouse Clinic (GMC) including behavioral, metabolic, and cardiologic tests as well as gene expression profiling to analyze the consequences of forebrain-specific SRF deletion in mice exposed to AS...
December 2, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27900272/return-to-physical-activity-after-gastrocnemius-recession
#18
Camelia Tang Qian Ying, Sean Lai Wei Hong, Bing Howe Lee, Gowreeson Thevendran
AIM: To prospectively investigate the time taken and patients' ability to resume preoperative level of physical activity after gastrocnemius recession. METHODS: Endoscopic gastrocnemius recession (EGR) was performed on 48 feet in 46 consecutive sportspersons, with a minimum follow-up of 24 mo. The Halasi Ankle Activity Score was used to quantify the level of physical activity. Time taken to return to work and physical activity was recorded. Functional outcomes were evaluated using the short form 36 (SF-36), American Orthopedic Foot and Ankle Society (AOFAS) Hindfoot score and modified Olerud and Molander (O and M) scores respectively...
November 18, 2016: World Journal of Orthopedics
https://www.readbyqxmd.com/read/27890615/egr2-is-a-gonadotropin-induced-survival-factor-that-controls-the-expression-of-ier3-in-ovarian-granulosa-cells
#19
Hanyong Jin, Miae Won, Eunkyoung Shin, Hong-Man Kim, Kangseok Lee, Jeehyeon Bae
Pituitary gonadotropins are key hormones that orchestrate the growth and development of ovarian follicles. However, limited information is available on intra-ovarian factors that mediate the actions of gonadotropins. In this study, we identified that the early growth response 2 gene (EGR2) is a gonadotropin-inducible gene in granulosa cells of rats and humans. Analysis of consensus EGR-binding elements (EBEs) showed that the immediate early response 3 gene (IER3) is a novel transcriptional target gene of EGR2 as confirmed by the luciferase assay, electrophoretic mobility-shift assay (EMSA), chromatin immunoprecipitation (ChIP), and western blot analysis...
January 22, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27889530/identification-of-proximal-biomarkers-of-pkc-agonism-and-evaluation-of-their-role-in-hiv-reactivation
#20
Sai Vikram Vemula, Jill W Maxwell, Alexey Nefedov, Bang-Lin Wan, Justin Steve, William Newhard, Rosa I Sanchez, David Tellers, Richard J Barnard, Wade Blair, Daria Hazuda, Andrea L Webber, Bonnie J Howell
DESIGN: The HIV latent CD4(+) T cell reservoir is broadly recognized as a barrier to HIV cure. Induction of HIV expression using protein kinase C (PKC) agonists is one approach under investigation for reactivation of latently infected CD4(+) T cells (Beans et al., 2013; Abreu et al., 2014; Jiang et al., 2014; Jiang and Dandekar, 2015). We proposed that an increased understanding of the molecular mechanisms of action of PKC agonists was necessary to inform on biological signaling and pharmacodynamic biomarkers...
November 23, 2016: Antiviral Research
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