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https://www.readbyqxmd.com/read/29910624/effects-of-the-combination-of-as-2-o-3-and-azt-on-proliferation-inhibition-and-apoptosis-induction-of-hepatoma-hepg2-cells-following-silencing-of-egr-1
#1
Chuan Zhao, Mei Wang, Yu Liu, Yongjuan Liang, Li Han, Che Chen
Context: Previous studies have demonstrated that 3'-azido-3'-deoxythymidine (AZT) and arsenic trioxide (As2 O3 ), traditional chemotherapy agents, can synergically inhibit the growth of hepatocellular carcinoma cells. However, the molecular mechanisms underlying As2 O3 and AZT anti-hepatoma activity are unknown. Objective: This study aimed to investigate the role of early growth response protein 1 (Egr-1) in the process of As2 O3 combined with AZT inhibiting proliferation and inducing apoptosis of human hepatocellular carcinoma HepG2 cells, and explore the possible mechanism...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29905975/the-grk2-promoter-is-regulated-by-early-growth-response-transcription-factor-egr-1
#2
Stefanie Klenke, Andrea Engler, Daniel Ecker, Crista Ochsenfarth, Nina Danowski, Jürgen Peters, Winfried Siffert, Ulrich H Frey
The G-protein-coupled receptor kinase 2 (GRK2) plays a major role in cardiovascular diseases and its expression is increased in heart failure. However, only little is known about factors being involved in up-regulation of GRK2 expression through transcriptional regulation of its promoter. Since the transcription factor early-growth response 1 (EGR-1) is also up-regulated in patients with heart failure, we tested the hypothesis that EGR-1 regulates GRK2 transcription. Stimulation of immortalized rat cardiomyocytes (H9c2) with phorbol 12-myristate 13-acetate (PMA) resulted in up-regulation of Egr-1 and subsequently of Grk2 mRNA expression, with maximum Grk2 expression (p=0...
June 15, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29890520/overcoming-heparin-associated-rt-qpcr-inhibition-and-normalization-issues-for-microrna-quantification-in-patients-with-acute-myocardial-infarction
#3
Jose Coelho-Lima, Ashfaq Mohammed, Suzanne Cormack, Samuel Jones, Rajiv Das, Mohaned Egred, Pedram Panahi, Simi Ali, Ioakim Spyridopoulos
BACKGROUND:  Cardiac-enriched micro ribonucleic acids (miRNAs) are released into the circulation following ST-elevation myocardial infarction (STEMI). Lack of standardized approaches for reverse transcription quantitative real-time polymerase chain reaction (RT-qPCR) data normalization and presence of RT-qPCR inhibitors (e.g. heparin) in patient blood samples have prevented reproducible miRNA quantification in this cohort and subsequent translation of these biomarkers to clinical practice...
June 11, 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29869214/effect-of-alumina-nano-additives-into-biodiesel-diesel-blends-on-the-combustion-performance-and-emission-characteristics-of-a-diesel-engine-with-exhaust-gas-recirculation
#4
Praveen Anchupogu, Lakshmi Narayana Rao, Balakrishna Banavathu
In the present study, the combined effect of alumina nanoparticles into the Calophyllum inophyllum biodiesel blend and exhaust gas recirculation on the combustion, performance, and emission characteristics of a diesel engine was investigated. The alumina (Al2 O3 ) nanoparticles with the mass fraction of 40 ppm were dispersed into the C. inophyllum biodiesel blend (20% of C. inophyllum biodiesel + 80% of diesel (CIB20)) by the ultrasonication process. Further, the exhaust gas recirculation was adopted to control the oxides of nitrogen (NOx) emissions of a diesel engine...
June 4, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29843768/egr-1-increases-angiogenesis-in-cartilage-via-binding-netrin-1-receptor-dcc-promoter
#5
Jun Sheng, Da Liu, Xia Kang, Ying Chen, Kai Jiang, Wei Zheng
BACKGROUND: Osteoarthritis (OA) is a joint disease characterized by degradation of cartilage. The etiology of OA is still unclear. Vascular endothelial growth factor (VEGF) plays a key role of angiogenesis in the pathogenesis of OA and contributes to the angiogenesis of NT-1/DCC. Whether or not NT-1/DCC and VEGF interact in regulating angiogenesis of OA cartilage is not known. METHODS: Histological studies for CD34, VEGF, and safranin-O staining were performed to determine angiogenesis and cartilage tissue injury...
May 29, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29787794/early-growth-response-gene-1-is-essential-for-urban-particulate-matter-induced-inflammation-and-mucus-hyperproduction-in-airway-epithelium
#6
Feng Xu, Jiaofei Cao, Man Luo, Luanqing Che, Wen Li, Songmin Ying, Zhihua Chen, Huahao Shen
Particulate matter (PM) has been implicated as a risk factor for human airway disorders. However, the biological mechanisms underlying the correlation between PM exposure and adverse airway effects have not yet been fully clarified. The objective of this study was to explore the possible role of early growth response gene 1 (Egr-1) in PM-induced toxic effects in pulmonary inflammation and mucus hyperproduction in vitro and in vivo. Particulate matter exposure induced a rapid Egr-1 expression in human bronchial epithelial (HBE) cells and in mouse lungs...
May 19, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29737506/hiv-1-protein-tat-1-72-impairs-neuronal-dendrites-via-activation-of-pp1-and-regulation-of-the-creb-bdnf-pathway
#7
Yu Liu, Deyu Zhou, Jiabin Feng, Zhou Liu, Yue Hu, Chang Liu, Xiaohong Kong
Despite the success of combined antiretroviral therapy in recent years, the prevalence of human immunodeficiency virus (HIV)-associated neurocognitive disorders in people living with HIV-1 is increasing, significantly reducing the health-related quality of their lives. Although neurons cannot be infected by HIV-1, shed viral proteins such as transactivator of transcription (Tat) can cause dendritic damage. However, the detailed molecular mechanism of Tat-induced neuronal impairment remains unknown. In this study, we first showed that recombinant Tat (1-72 aa) induced neurotoxicity in primary cultured mouse neurons...
May 8, 2018: Virologica Sinica
https://www.readbyqxmd.com/read/29722565/mmp-12-activates-protease-activated-receptor-par-1-upregulates-placenta-growth-factor-and-leads-to-pulmonary-emphysema
#8
Hsin-Han Hou, Hao-Chien Wang, Shih-Lung Cheng, Yen-Fu Chen, Kai-Zen Lu, Chong-Jen Yu
Due to the expansion of aging and smoking populations, chronic pulmonary obstructive disease (COPD) is predicted to be the third leading cause of death worldwide in 2030. It is therefore pertinent to develop effective therapy to improve management for COPD. Cigarette smoke-mediated protease-antiprotease imbalance is a major pathogenic mechanism for COPD and results in massive pulmonary infiltration of neutrophils and macrophages, releasing excessive neutrophil elastase (NE) and matrix metalloproteinases (MMPs)...
May 3, 2018: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29721795/topsis-based-parametric-optimization-of-compression-ignition-engine-performance-and-emission-behavior-with-bael-oil-blends-for-different-egr-and-charge-inlet-temperature
#9
Krishnamoorthi Muniappan, Malayalamurthi Rajalingam
The demand for higher fuel energy and lesser exhaust emissions of diesel engines can be achieved by fuel being used and engine operating parameters. In the present work, effects of engine speed (RPM), injection timing (IT), injection pressure (IP), and compression ratio (CR) on performance and emission characteristics of a compression ignition (CI) engine were investigated. The ternary test fuel of 65% diesel + 25% bael oil + 10% diethyl ether (DEE) was used in this work and test was conducted at different charge inlet temperature (CIT) and exhaust gas recirculation (EGR)...
May 2, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29674380/odor-discrimination-learning-in-the-indian-greater-short-nosed-fruit-bat-cynopterus-sphinx-differential-expression-of-egr-1-c-fos-and-pp-1-in-the-olfactory-bulb-amygdala-and-hippocampus
#10
Murugan Mukilan, Wieslaw Bogdanowicz, Ganapathy Marimuthu, Koilmani Emmanuvel Rajan
Activity-dependent expression of immediate-early genes (IEGs) is induced by exposure to odor. The present study was designed to investigate whether there is differential expression of IEGs ( Egr-1 , C-fos ) in the brain region mediating olfactory memory in the Indian greater short-nosed fruit bat Cynopterus sphinx We assumed that differential expression of IEGs in different brain regions may orchestrate a preference odor (PO) and aversive odor (AO) memory in C. sphinx We used preferred (0.8% wt/wt of cinnamon powder) and aversive (0...
April 19, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29601855/egr-1-expression-in-catecholamine-synthesizing-neurons-reflects-auditory-learning-and-correlates-with-responses-in-auditory-processing-areas
#11
Jennifer B Dai, Yining Chen, Jon T Sakata
Distinguishing between familiar and unfamiliar individuals is an important task that shapes the expression of social behavior. As such, identifying the neural populations involved in processing and learning the sensory attributes of individuals is important for understanding mechanisms of behavior. Catecholamine-synthesizing neurons have been implicated in sensory processing, but relatively little is known about their contribution to auditory learning and processing across various vertebrate taxa. Here we investigated the extent to which immediate early gene expression in catecholaminergic circuitry reflects information about the familiarity of social signals and predicts immediate early gene expression in sensory processing areas in songbirds...
May 21, 2018: Neuroscience
https://www.readbyqxmd.com/read/29579710/bu-shen-zhu-yun-decoction-promotes-synthesis-and-secretion-of-fsh%C3%AE-and-lh%C3%AE-in-anterior-pituitary-cells-in-vitro
#12
Xiaofei Jiang, Huifang Zhou, Mingqing Shi, Boru Zhou, Bei Liu, Yizhen Yuan, Jinjun Shan, Jianya Xu, Tong Xie
Luteal phase defects (LPD) are an important etiology of infertility which has increased in recent years. Studies have shown that bu-shen-zhu-yun decoction (BSZY-D) can lower the expression of estrogen receptor and progesterone receptor, in rats endometrium of embryonic implantation period, which upregulated by mifepristone, and improve uterine receptivity. The aim of present study was to determine the effect of BSZY-D on the synthesis and secretion of gonadotropic hormones in the anterior pituitary cells of rats...
June 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29563122/epigenetic-programming-of-t-cells-impacts-immune-reconstitution-in-hematopoietic-stem-cell-transplant-recipients
#13
Kristine Hardy, Corey Smith, Wen Juan Tu, Robert McCuaig, Archana Panikkar, Vijayendra Dasari, Fan Wu, Siok-Keen Tey, Geoffrey R Hill, Rajiv Khanna, Sudha Rao
Immune reconstitution following hematopoietic stem cell transplantation (HSCT) is critical in preventing harmful sequelae in recipients with cytomegalovirus (CMV) infection. To understand the molecular mechanisms underlying immune reconstitution kinetics, we profiled the transcriptome-chromatin accessibility landscape of CMV-specific CD8+ T cells from HCST recipients with different immune reconstitution efficiencies. CMV-specific T cells from HSCT recipients with stable antiviral immunity expressed higher levels of interferon/defense response and cell cycle genes in an interconnected network involving PI3KCG , STAT5B , NFAT , RBPJ , and lower HDAC6 , increasing chromatin accessibility at the enhancer regions of immune and T-cell receptor signaling pathway genes...
March 27, 2018: Blood Advances
https://www.readbyqxmd.com/read/29561772/the-host-factor-early-growth-response-gene-egr-1-regulates-vaccinia-virus-infectivity-during-infection-of-starved-mouse-cells
#14
Leonardo C de Oliveira, Bruno S A F Brasil, Bethany Unger, Giliane S Trindade, Jonatas S Abrahão, Erna G Kroon, Paula Traktman, Cláudio A Bonjardim
Evolution has equipped poxvirus genomes with the coding capacity for several virus-host interaction products which interfere with host cell gene expression and protein function, creating an adequate intracellular environment for a productive infection. We show here that Vaccinia virus (VACV) induces the expression of the cellular transcription factor EGR-1 (early growth response-1) in Mouse Embryonic Fibroblasts (MEFs) through the MEK (mitogen-activated protein kinase (MAPK)/ERK)/ERK (extracellular signal-regulated kinases) pathway, from 3 to 12 h post infection (h...
March 21, 2018: Viruses
https://www.readbyqxmd.com/read/29550088/update-in-the-percutaneous-management-of-coronary-chronic-total-occlusions
#15
REVIEW
Peter Tajti, M Nicholas Burke, Dimitri Karmpaliotis, Khaldoon Alaswad, Gerald S Werner, Lorenzo Azzalini, Mauro Carlino, Mitul Patel, Kambis Mashayekhi, Mohaned Egred, Oleg Krestyaninov, Dmitrii Khelimskii, William J Nicholson, Imre Ungi, Alfredo R Galassi, Subhash Banerjee, Emmanouil S Brilakis
Percutaneous coronary intervention (PCI) for chronic total occlusions (CTOs) has been rapidly evolving during recent years. With improvement in equipment and techniques, high success rates can be achieved at experienced centers, although overall success rates remain low. Prospective, randomized-controlled data regarding optimal use and indications for CTO PCI remain limited. CTO PCI should be performed when the anticipated benefit exceeds the potential risk. New high-quality studies of the clinical outcomes and techniques of CTO PCI are needed, as is the expansion of expert centers and operators that can achieve excellent clinical outcomes in this challenging patient and lesion subgroup...
April 9, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29543533/early-growth-response-1-negative-feedback-regulates-skeletal-muscle-postprandial-insulin-sensitivity-via-activating-ptp1b-transcription
#16
Jing Wu, Wei-Wei Tao, Dan-Yang Chong, Shan-Shan Lai, Chuang Wang, Qi Liu, Tong-Yu Zhang, Bin Xue, Chao-Jun Li
Postprandial insulin desensitization plays a critical role in maintaining whole-body glucose homeostasis by avoiding the excessive absorption of blood glucose; however, the detailed mechanisms that underlie how the major player, skeletal muscle, desensitizes insulin action remain to be elucidated. Herein, we report that early growth response gene-1 ( Egr-1) is activated by insulin in skeletal muscle and provides feedback inhibition that regulates insulin sensitivity after a meal. The inhibition of the transcriptional activity of Egr-1 enhanced the phosphorylation of the insulin receptor (InsR) and Akt, thus increasing glucose uptake in L6 myotubes after insulin stimulation, whereas overexpression of Egr-1 decreased insulin sensitivity...
March 15, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29535721/early-growth-response-gene-2-expressing-cd4-lag3-regulatory-t-cells-the-therapeutic-potential-for-treating-autoimmune-diseases
#17
REVIEW
Tomohisa Okamura, Kazuhiko Yamamoto, Keishi Fujio
Regulatory T cells (Tregs) are necessary for the maintenance of immune tolerance. Tregs are divided into two major populations: one is thymus derived and the other develops in the periphery. Among these Tregs, CD4+ CD25+ Tregs, which mainly originate in the thymus, have been extensively studied. Transcription factor Foxp3 is well known as a master regulatory gene for the development and function of CD4+ CD25+ Tregs. On the other hand, peripheral Tregs consist of distinct cell subsets including Foxp3-dependent extrathymically developed Tregs and interleukin (IL)-10-producing type I regulatory T (Tr1) cells...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29520222/immediate-early-genes-anchor-a-biological-pathway-of-proteins-required-for-memory-formation-long-term-depression-and-risk-for-schizophrenia
#18
Ketan K Marballi, Amelia L Gallitano
While the causes of myriad medical and infectious illnesses have been identified, the etiologies of neuropsychiatric illnesses remain elusive. This is due to two major obstacles. First, the risk for neuropsychiatric disorders, such as schizophrenia, is determined by both genetic and environmental factors. Second, numerous genes influence susceptibility for these illnesses. Genome-wide association studies have identified at least 108 genomic loci for schizophrenia, and more are expected to be published shortly...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29520172/fluvastatin-inhibits-advanced-glycation-end-products-induced-proliferation-migration-and-extracellular-matrix-accumulation-in-vascular-smooth-muscle-cells-by-targeting-connective-tissue-growth-factor
#19
Ae-Rang Hwang, Ju-Ock Nam, Young Jin Kang
Connective tissue growth factor (CTGF) is a novel fibrotic mediator, which is considered to mediate fibrosis through extracellular matrix (ECM) synthesis in diabetic cardiovascular complications. Statins have significant immunomodulatory effects and reduce vascular injury. We therefore examined whether fluvastatin has anti-fibrotic effects in vascular smooth muscle cells (VSMCs) and elucidated its putative transduction signals. We show that advanced glycation end products (AGEs) stimulated CTGF mRNA and protein expression in a time-dependent manner...
March 2018: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29518540/regulation-of-the-voltage-gated-ca-2-channel-ca-v-%C3%AE-2-%C3%AE-1-subunit-expression-by-the-transcription-factor-egr-1
#20
Ricardo González-Ramírez, Elizabeth Martínez-Hernández, Alejandro Sandoval, Kimberly Gómez-Mora, Ricardo Felix
It is well known that the CaV α2 δ auxiliary subunit regulates the density of high voltage-activated Ca2+ channels in the plasma membrane and that alterations in their functional expression might have implications in the pathophysiology of diverse human diseases such as neuropathic pain. However, little is known concerning the transcriptional regulation of this protein. We previously characterized the promoter of CaV α2 δ, and here we report its regulation by the transcription factor Egr-1. Using the neuroblastoma N1E-115 cells, we found that Egr-1 interacts specifically with its binding site in the promoter, affecting the transcriptional regulation of CaV α2 δ...
April 23, 2018: Neuroscience Letters
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