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Chronic kidney failure

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https://www.readbyqxmd.com/read/29928990/asymmetric-dimethylarginine-adma-as-an-important-risk-factor-for-the-increased-cardiovascular-diseases-and-heart-failure-in-chronic-kidney-disease
#1
REVIEW
Xiaoong Liu, Xin Xu, Ruru Shang, Yingjie Chen
Patients with chronic kidney disease have an increased cardiovascular morbidity and mortality. It has been recognized that the traditional cardiovascular risk factors could only partially explain the increased cardiovascular morbidity and mortality in patients with chronic kidney disease. Asymmetric dimethylarginine (ADMA) and N-monomethy l-arginine (L-NMMA) are endogenous inhibitors of nitric oxide synthases that attenuate nitric oxide production and enhance reactive oxidative specie generation. Increased plasma ADMA and/or L-NMMA are strong and independent risk factor for chronic kidney disease, and various cardiovascular diseases such as hypertension, coronary artery disease, atherosclerosis, diabetes, and heart failure...
June 18, 2018: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/29925739/-treatment-of-mandibular-fracture-associated-infectious-pseudarthrosis-accompanied-by-osteomyelitis-in-a-peritoneal-dialysis-patient
#2
Soichi Hirashima, Akihiko Miyawaki, Kotaro Oho, Yawaka Shitozawa, Motohiro Arai, Norihiko Furuta, Ryoichi Oya
Peritoneal dialysis can be performed at home, and the transfer of solutes in the blood and other body fluids is slow compared to hemodialysis, reducing the load on the circulatory organs and lessening the frequency of hospital visits. We encountered a male patient in his 70s on peritoneal dialysis for end-stage renal failure who developed obsolete mandibular fracture-associated pseudarthrosis accompanied by osteomyelitis, which was treated with noninvasive reduction and fixation using circumferential wiring after the resolution of inflammation...
2018: Journal of UOEH
https://www.readbyqxmd.com/read/29925521/caspase-3-is-a-pivotal-regulator-of-microvascular-rarefaction-and-renal-fibrosis-after-ischemia-reperfusion-injury
#3
Bing Yang, Shanshan Lan, Mélanie Dieudé, Jean-Paul Sabo-Vatasescu, Annie Karakeussian-Rimbaud, Julie Turgeon, Shijie Qi, Lakshman Gunaratnam, Natalie Patey, Marie-Josée Hébert
Background Ischemia-reperfusion injury (IRI) is a major risk factor for chronic renal failure. Here, we characterize the different modes of programmed cell death in the tubular and microvascular compartments during the various stages of IRI-induced AKI, and their relative importance to renal fibrogenesis. Methods We performed unilateral renal artery clamping for 30 minutes and contralateral nephrectomy in wild-type mice (C57BL/6) or caspase-3-/- mice. Results Compared with their wild-type counterparts, caspase-3-/- mice in the early stage of AKI had high urine cystatin C levels, tubular injury scores, and serum creatinine levels...
June 20, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29917301/prevalence-and-prognostic-impact-of-non-cardiac-co-morbidities-in-heart-failure-outpatients-with-preserved-and-reduced-ejection-fraction-a-community-based-study
#4
Annamaria Iorio, Michele Senni, Giulia Barbati, Stephen J Greene, Stefano Poli, Elena Zambon, Concetta Di Nora, Giovanni Cioffi, Luigi Tarantini, Antonello Gavazzi, Gianfranco Sinagra, Andrea Di Lenarda
AIM: To assess adverse outcomes attributable to non-cardiac co-morbidities and to compare their effects by left ventricular ejection fraction (LVEF) group [LVEF <50% (heart failure with reduced ejection fraction, HFrEF), LVEF ≥50% (heart failure with preserved ejection fraction, HFpEF)] in a contemporary, unselected chronic heart failure population. METHODS AND RESULTS: This community-based cohort enrolled patients from October 2009 to December 2013. Adjusted hazard ratio (HR) and the population attributable fraction (PAF) were used to compare the contribution of 15 non-cardiac co-morbidities to adverse outcome...
June 19, 2018: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29915813/mmp-2-and-timp-2-in-patients-with-heart-failure-and-chronic-kidney-disease
#5
Malgorzata Kobusiak-Prokopowicz, Justyna Krzysztofik, Konrad Kaaz, Beata Jolda-Mydlowska, Andrzej Mysiak
The aim of the study was to assess MMP-2 (matrix metalloproteinase-2) and TIMP-2 (tissue inhibitor of metalloproteinase-2) serum levels in patients with diverse types of heart failure (HF) and chronic kidney disease (CKD). 101 patients with chronic HF were enrolled. Each patient has assessed the serum levels of MMP-2, TIMP-2, and NT-proBNP. Patients were initially classified into 2 groups based on their LVEF. 43 patients were classified into the HFREF group (HF with Reduced Ejection Fraction) and 58 characterized as HFPEF (HF with Preserved Ejection Fraction)...
2018: Open Medicine (Warsaw, Poland)
https://www.readbyqxmd.com/read/29913911/buprenorphine-clinically-useful-but-often-misunderstood
#6
Stephen Butler
Background There are a number of false myths about buprenorphine based on unconfirmed animal data, even from isolated animal organs, and early clinical research. These myths came into textbooks on pharmacology and pain about 30 years ago and have been difficult to eradicate. Animal models of pain and pain relief are notoriously unreliable as predictors of human clinical effects. The fact is that in clinical practice there is NO bell-shaped dose-response curve, there is NO plateau on the dose-response curve, and there is NO antagonist effect from buprenorphine on other mu-opioid agonists...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29911007/elevated-mean-pulmonary-artery-pressure-and-right-ventricular-dysfunction-in-children-with-chronic-kidney-disease
#7
Igoche D Peter, Mustafa O Asani, Ibrahim Aliyu, Patience N Obiagwu
Background: Elevated mean pulmonary artery pressure (mPAP) and right heart failure increase mortality in patients with chronic kidney disease (CKD). Objectives: The objective of this study is to determine the prevalence of elevated mPAP in children with CKD compared with matched controls and to ascertain the relationship between elevated mPAP with right ventricular dysfunction and history of hemodialysis. Materials and Methods: A cross-sectional comparative study of mPAP and tricuspid annular plane systolic excursion of 21 children with CKD and age- and sex-matched controls asymptomatic for cardiac disease was conducted...
April 2018: Journal of Cardiovascular Echography
https://www.readbyqxmd.com/read/29910108/prevalence-predictors-and-impact-of-bacterial-infection-in-acute-on-chronic-liver-failure-patients
#8
Shalimar, Gyanranjan Rout, Shekhar S Jadaun, Gyan Ranjan, Saurabh Kedia, Deepak Gunjan, Baibaswata Nayak, Subrat Kumar Acharya, Ajay Kumar, Arti Kapil
BACKGROUND: Acute on chronic liver failure (ACLF) is associated with high short term mortality. We aimed to evaluate the prevalence, predictors and impact of bacterial infection in ACLF. METHODS: Consecutive hospitalized patients with cirrhosis and acute decompensation (AD), from January 2011-March 2017, were included. Predictors of survival and infection were assessed. RESULTS: 572 patients with cirrhosis and AD were classified into 3 groups - no infection (group 1, n = 190, 33...
May 28, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29909119/cellular-and-molecular-mechanisms-of-kidney-fibrosis
#9
REVIEW
Sonja Djudjaj, Peter Boor
Renal fibrosis is the final pathological process common to any ongoing, chronic kidney injury or maladaptive repair. It is considered as the underlying pathological process of chronic kidney disease (CKD), which affects more than 10% of world population and for which treatment options are limited. Renal fibrosis is defined by excessive deposition of extracellular matrix, which disrupts and replaces the functional parenchyma that leads to organ failure. Kidney's histological structure can be divided into three main compartments, all of which can be affected by fibrosis, specifically termed glomerulosclerosis in glomeruli, interstitial fibrosis in tubulointerstitium and arteriosclerosis and perivascular fibrosis in vasculature...
June 14, 2018: Molecular Aspects of Medicine
https://www.readbyqxmd.com/read/29908131/low-body-mass-index-is-a-risk-factor-for-hyperkalaemia-associated-with-angiotensin-converting-enzyme-inhibitors-and-angiotensin-ii-receptor-blockers-treatments
#10
T Hirai, R Yamaga, A Fujita, T Itoh
WHAT IS KNOWN AND OBJECTIVE: Angiotensin converting enzyme inhibitors (ACEI) and angiotensin II receptor blockers (ARB) represent the cornerstones of hypertension and congestive heart failure treatment. Risk factors for hyperkalaemia associated with ACEI and ARB are chronic kidney disease and concomitant medications which increase serum potassium level. Body mass index (BMI) also affects pharmacokinetics of ACEI and ARB and potassium disposition. We evaluated the relationship between BMI and hyperkalaemia associated with ACEI and ARB treatments...
June 16, 2018: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29907698/selective-activation-of-retinoic-acid-%C3%AE-2-receptors-exerts-cardioprotective-effects
#11
Alice Marino, Takuya Sakamoto, Xiao-Han Tang, Lorraine J Gudas, Roberto Levi
We previously discovered that oral treatment with AC261066, a synthetic selective agonist for the retinoic acid β2-receptor (RARβ2), decreases oxidative stress in the liver, pancreas, and kidney of mice fed a high-fat diet (HFD). Since hyperlipidemic states are causally associated with myocardial ischemia and oxidative stress, we have now investigated the effects of AC261066 in an ex-vivo ischemia/reperfusion (I/R) injury model in hearts of two prototypic dysmetabolic mice. We found that a 6-week oral treatment with AC261066 in both genetically hypercholesterolemic (ApoE-/-) and obese (HFD-fed) wild-type mice exerts protective effects when their hearts are subsequently subjected to I/R ex vivo in the absence of added drug...
June 15, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29907655/causes-and-predictors-of-readmission-in-patients-with-atrial-fibrillation-undergoing-catheter-ablation-a-national-population-based-cohort-study
#12
Shilpkumar Arora, Sopan Lahewala, Byomesh Tripathi, Varshil Mehta, Varun Kumar, Divya Chandramohan, Alejandro Lemor, Mihir Dave, Nileshkumar Patel, Nilay V Patel, Ghanshyam Palamaner Subash Shantha, Juan Viles-Gonzalez, Abhishek Deshmukh
BACKGROUND: Reducing readmission after catheter ablation (CA) in atrial fibrillation (AF) is important. METHODS AND RESULTS: We utilized National Readmission Data (NRD) 2010-2014. AF was identified by International Classification of Diseases, Ninth Edition, Clinical Modification (ICD-9-CM) diagnostic code 427.31 in the primary field, while first CA of AF was identified via ICD-9 -procedure code 37.34. Any admission within 30 or 90 days of index admission was considered a readmission...
June 15, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29906338/a-nutraceutical-diet-based-on-lespedeza-spp-vaccinium-macrocarpon-and-taraxacum-officinale-improves-spontaneous-feline-chronic-kidney-disease
#13
Alessandro Di Cerbo, Tommaso Iannitti, Gianandrea Guidetti, Sara Centenaro, Sergio Canello, Raffaella Cocco
Chronic kidney disease is characterized by structural and/or functional impairment of one or both kidneys persisting for more than 3 months. In cats, chronic kidney disease can frequently occur in animals aged over 9 years with an incidence of approximately 10%. Thirty-four client-owned, neutered cats, suffering from stage II-III chronic kidney disease and diagnosed according to the International Renal Interest Society guidelines were randomly assigned to receive either a control diet (n = 17) or a nutraceutical diet (ND; n = 17) for 90 days...
June 2018: Physiological Reports
https://www.readbyqxmd.com/read/29905409/l-fabp-and-il-6-as-markers-of-chronic-kidney-damage-in-children-after-hemolytic-uremic-syndrome
#14
Katarzyna Lipiec, Piotr Adamczyk, Elżbieta Świętochowska, Katarzyna Ziora, Maria Szczepańska
BACKGROUND: Hemolytic-uremic syndrome (HUS) is a form of thrombotic microangiopathy, in the course of which some patients may develop chronic kidney disease (CKD). From a clinical point of view, it is important to search for markers that allow for early identification of patients at risk of a poor prognosis. OBJECTIVES: The study evaluated the serum and urine levels of liver-type fatty acid binding protein (L-FABP) and interleukin 6 (IL-6). MATERIAL AND METHODS: The study was conducted in 29 children with a history of HUS...
June 13, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29904118/psoriasis-risk-in-patients-with-diabetic-retinopathy-a-nationwide-population-based-study
#15
Ji Hyun Lee, Ju Hee Han, Kyung Do Han, Young Min Park, Jun Young Lee, Yong-Gyu Park, Young Bok Lee
Psoriasis is a chronic cutaneous disease known to be related with systemic disease; however, the association between psoriasis and diabetic complications has not been previously reported. Diabetic microvascular complications include diabetic retinopathy (DR), nephropathy, and neuropathy, and overt diabetic nephropathy can lead to the end-stage renal disease (ESRD).The present study investigated the association between psoriasis and non-proliferative DR (NPDR) or proliferative DR (PDR) or ESRD. We analyzed the relationship between diabetic complication and psoriasis using data from the National Health Insurance Service between 2009 and 2015...
June 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29902370/the-instituto-mexicano-del-seguro-social-gives-dialysis-therapies-to-426-students-without-cost
#16
Antonio Méndez-Durán, Manuel Humberto Ignorosa-Luna, Gilberto Pérez-Aguilar, Francisco Jesús Rivera-Rodríguez, Luis Rafael López-Ocaña
Background: The Instituto Mexicano del Seguro Social (IMSS) is the institution with the greatest health coverage in Mexico. In adherence to existing and committed to provide specialized services to specific populations (vulnerable age groups, such as children and young people in primary, secondary and higher education, productive and without social security educational training), this gives the renal replacement therapy -peritoneal dialysis and hemodialysis- at no cost to students. Methods: Cross-sectional and retrospective study conducted from 1 to 30 September 2016; Census Patients with Chronical Renal Failure, sociodemographic and type of therapy are identified; direct costs are estimated...
March 2018: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29901621/thirty-day-rehospitalizations-among-elderly-patients-with-acute-myocardial-infarction-impact-of-postdischarge-ambulatory-care
#17
Claire Zabawa, Jonathan Cottenet, Marianne Zeller, Grégoire Mercier, Victor G Rodwin, Yves Cottin, Catherine Quantin
Rehospitalization after acute myocardial infarction (AMI) is common in elderly patients. It increases morbimortality and health care expenditures. The association between ambulatory care after discharge for AMI and rehospitalization has never been studied in France. We analyzed the impact of ambulatory care on rehospitalization of elderly patients (≥65 years) within 30 days after hospital discharge.We conducted a nationwide population-based study of elderly patients hospitalized with a main diagnosis of AMI in France between 2011 and 2013...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29900001/transfusion-management-of-incident-dialysis-patients-in-canada-a-prospective-observational-study
#18
Aminu K Bello, Christine M Ribic, Serge H Cournoyer, Mercedeh Kiaii, Martine LeBlanc, Melanie Poulin-Costello, David N Churchill, Norman Muirhead
Background: Several studies have demonstrated harm associated with using erythropoiesis-stimulating agents (ESA) to achieve higher hemoglobin (Hb) levels. Subsequently, more conservative use of ESAs has changed anemia therapy in patients with chronic renal failure. Objective: The objectives were to identify transfusion rates in hemodialysis (HD) patients during the first year of therapy, to identify factors associated with the probability of transfusion, describe reasons for the transfusions, and identify the Hb values associated with each transfusion...
2018: Canadian Journal of Kidney Health and Disease
https://www.readbyqxmd.com/read/29897288/intermittent-hypoxia-exacerbates-increased-blood-pressure-in-rats-with-chronic-kidney-disease
#19
Jennifer L Riggs, Carolyn E Pace, Heather H Ward, Laura V Gonzalez Bosc, Lynnette Rios, Adleaeda Barrera, Nancy L Kanagy
Kidney injury and sleep apnea (SA) are independent risk factors for hypertension. Exposing rats to intermittent hypoxia (IH) to simulate SA increases blood pressure while adenine feeding causes persistent kidney damage to model chronic kidney disease (CKD). We hypothesized that exposing CKD rats to IH would exacerbate the development of hypertension and renal failure. Male Sprague-Dawley rats were fed a 0.2% adenine or control diet until blood urea nitrogen (BUN) was &gt; 120 mg/dL in adenine fed rats (14 {plus minus} 4 days)...
June 13, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29897287/the-uroplakin-plaque-promotes-renal-structural-integrity-during-congenital-and-acquired-urinary-tract-obstruction
#20
Ashley R Jackson, Birong Li, Shira H Cohen, Christina B Ching, Kirk M McHugh, Brian Becknell
Urinary tract obstruction represents a common cause of kidney injury across the human lifespan, resulting in chronic kidney disease and end stage renal disease. Yet the extent of obstructive renal damage can be heterogeneous between individuals, implying the existence of unknown mechanisms that protect against or accelerate kidney injury. In this study, we investigated the role of urothelial remodeling in renal adaptation during congenital and acquired obstruction. In the Megabladder ( Mgb-/- ) model of congenital obstruction and unilateral ureteral ligation model of acute obstruction, progressive hydronephrosis is strongly associated with dynamic reorganization of the renal urothelium, which elaborates a continuous Uroplakin (Upk) plaque...
June 13, 2018: American Journal of Physiology. Renal Physiology
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