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https://www.readbyqxmd.com/read/29150900/genetic-overlap-between-epilepsy-and-schizophrenia-evidence-from-cross-phenotype-analysis-in-hong-kong-chinese-population
#1
Hongsheng Gui, Miaoxin Li, Pak C Sham, Larry Baum, Patrick Kwan, Stacey S Cherny
Epilepsy and schizophrenia are common and typical neurological or mental illness respectively, and sometimes they comorbid in the same patients, however the underlying genetic relationship between the two brain diseases is still not fully understood. To investigate the possible genetic contribution to their comorbidity, we performed polygenic risk score (PRS) analyses and genetic correlation estimation so as to identify the overall genetic overlap between the two diseases. The global schizophrenia PRS is strongly associated with schizophrenia phenotype in Hong Kong population (odds ratio = 1...
November 17, 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/29150533/disparity-between-indications-for-and-utilization-of-implantable-cardioverter-defibrillators-in-asian-patients-with-heart-failure
#2
Yvonne May Fen Chia, Tiew-Hwa Katherine Teng, Eugene S J Tan, Wan Ting Tay, A Mark Richards, Calvin Woon Loong Chin, Wataru Shimizu, Sang Weon Park, Chung-Lieh Hung, Lieng H Ling, Tachapong Ngarmukos, Razali Omar, Bambang B Siswanto, Calambur Narasimhan, Eugene B Reyes, Cheuk-Man Yu, Inder Anand, Michael R MacDonald, Jonathan Yap, Shu Zhang, Eric A Finkelstein, Carolyn S P Lam
BACKGROUND: Implantable cardioverter defibrillators (ICDs) are lifesaving devices for patients with heart failure (HF) and reduced ejection fraction. However, utilization and determinants of ICD insertion in Asia are poorly defined. We determined the utilization, associations of ICD uptake, patient-perceived barriers to device therapy and, impact of ICDs on mortality in Asian patients with HF. METHODS AND RESULTS: Using the prospective ASIAN-HF (Asian Sudden Cardiac Death in Heart Failure) registry, 5276 patients with symptomatic HF and reduced ejection fraction (HFrEF) from 11 Asian regions and across 3 income regions (high: Hong Kong, Japan, Korea, Singapore, and Taiwan; middle: China, Malaysia, and Thailand; and low: India, Indonesia, and Philippines) were studied...
November 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/29149335/liberty-in-health-care-a-comparative-study-between-hong-kong-and-mainland-china
#3
Jingxian Wu, Ying Mao
This essay contends that individual liberty, understood as the permissibility of making choices about one's own health care in support of one's own good and the good of one's family utilizing private resources, is central to the moral foundations of a health care system. Such individual freedoms are important not only because they often support more efficient and effective health care services, but because they permit individuals to fulfill important moral duties. A comparative study of the health care systems in Hong Kong and mainland China is utilized to illustrate the conceptual and moral concerns at stake...
November 15, 2017: Journal of Medicine and Philosophy
https://www.readbyqxmd.com/read/29149286/economic-costs-attributable-to-smoking-in-hong-kong-in-2011-a-possible-increase-from-1998
#4
Jing Chen, Sarah McGhee, Tai Hing Lam
Background: Reduction in smoking prevalence does not necessarily reduce the costs of smoking as evidence shows in developed countries. We provide up-to-date estimates for direct and indirect costs attributable to smoking in Hong Kong in 2011 and compare with our 1998 estimates. Methods: We took a societal perspective to include lives and life years lost, health care costs and time lost from work in the costing. We followed guidelines on estimating costs of active smoking for those aged 35 years or above (35+) and costs due to SHS exposure for 35+, infants aged 12 months and under and children aged 15 and below...
November 15, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/29148797/nigegladines-a-c-three-thymoquinone-dimers-from-nigella-glandulifera
#5
Jie Tian, Chao Han, Wen-Hua Guo, Yong Yin, Xiao-Bing Wang, Hong-Bin Sun, He-Quan Yao, Yong Yang, Chen Wang, Chang Liu, Ming-Hua Yang, Ling-Yi Kong
Nigegladines A-C (1-3), three thymoquinone dimers, were isolated from the seeds of Nigella glandulifera. Racemic 1 possesses a unique tricyclo[5.4.0.1(2,6)]dodecane carbon skeleton, and compounds 2 and 3 are two unusual diterpenoid alkaloids with indole cores. Their structures were determined by extensive spectroscopic analyses, and that of 1 was confirmed by single-crystal X-ray diffraction. Both (+)-1 and (-)-1 exhibited significant protective effects against hypoxia/reoxygenation-induced H9c2 myocardial cell injury...
November 17, 2017: Organic Letters
https://www.readbyqxmd.com/read/29147556/mechanism-of-biosurfactant-adsorption-to-oil-water-interfaces-from-millisecond-scale-tensiometry-measurements
#6
Lingling Kong, Kadi Liis Saar, Raphael Jacquat, Liu Hong, Aviad Levin, Hongze Gang, Ruqiang Ye, Bozhong Mu, Tuomas P J Knowles
Many biological molecules are by their nature amphiphilic and have the ability to act as surfactants, stabilizing interfaces between aqueous and immiscible oil phases. In this paper, we explore the adsorption kinetics of surfactin, a naturally occurring cyclic lipopeptide, at hexadecane/water interfaces and compare and contrast its adsorption behaviour with that of synthetic alkyl benzene sulfonate isomers, through direct measurements of changes in interfacial tension upon surfactant adsorption. We access millisecond time resolution in kinetic measurements by making use of droplet microfluidics to probe the interfacial tension of hexadecane droplets dispersed in a continuous water phase through monitoring their deformation when the droplets are exposed to shear flows in a microfluidic channel with regular corrugations...
December 6, 2017: Interface Focus
https://www.readbyqxmd.com/read/29146994/usefulness-of-the-delta-neutrophil-index-to-predict-30-day-mortality-in-patients-with-st-segment-elevation-myocardial-infarction
#7
Taeyoung Kong, Tae Hoon Kim, Yoo Seok Park, Sung Phil Chung, Hye Sun Lee, Jung Hwa Hong, Jong Wook Lee, Je Sung You, Incheol Park
This study aimed to evaluate the association between the delta neutrophil index (DNI), which reflects immature granulocytes, and the severity of ST-elevation myocardial infarction (STEMI), as well as to determine the significance of the DNI as a prognostic marker for early mortality and other clinical outcomes in patients with STEMI who underwent reperfusion. This retrospective, observational cohort study was conducted using patients prospectively integrated in a critical pathway program for STEMI. We included 842 patients diagnosed with STEMI who underwent primary percutaneous coronary intervention (pPCI)...
November 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29146885/mammary-phyllodes-tumour-a-15-year-multicentre-clinical-review
#8
Michael Co, Clement Chen, Julia Y Tsang, Gary Tse, Ava Kwong
AIMS: Phyllodes tumour (PT) is an uncommon fibroepithelial tumour of the breast. It has a spectrum of aggressiveness in biological behaviour with chance of local recurrence and, occasionally, metastasis. METHODS: A 15-year retrospective review from a multicentre database in Hong Kong was performed. RESULTS: Clinical and pathological records of 465 patients with 469 PTs between 1998 and 2014 were reviewed. Median age of occurrence was 44 years (range 12-86 years)...
November 16, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29145620/head-and-neck-cancer-in-hong-kong
#9
Wai Tong Ng, Edwin C Y Wong, Victor H F Lee, Jimmy Y W Chan, Anne W M Lee
Head and neck cancer is a major cause of morbidity and mortality in Hong Kong. HNC is well-known for its heterogeneity in epidemiology, clinical behavior, clinic-pathological features and patient characteristics. Treatment strategies for this heterogeneous disease vary greatly in different parts of the world, depending on availability of resources, local expertise and experience. Extensive research in head and neck cancer, particularly nasopharyngeal carcinoma, has been conducted in Hong Kong in the past few decades...
November 14, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29143178/transgenic-cotton-co-expressing-chimeric-vip3acaa-and-cry1ac-confers-effective-protection-against-cry1ac-resistant-cotton-bollworm
#10
Wen-Bo Chen, Guo-Qing Lu, Hong-Mei Cheng, Chen-Xi Liu, Yu-Tao Xiao, Chao Xu, Zhi-Cheng Shen, Mario Soberón, Alejandra Bravo, Kong-Ming Wu
Wide planting of transgenic Bt cotton in China since 1997 to control cotton bollworm (Helicoverpa armigera) has increased yields and decreased insecticide use, but the evolution of resistance to Bt cotton by H. armigera remains a challenge. Toward developing a new generation of insect-resistant transgenic crops, a chimeric protein of Vip3Aa1 and Vip3Ac1, named Vip3AcAa, having a broader insecticidal spectrum, was specifically created previously in our laboratory. In this study, we investigated cross resistance and interactions between Vip3AcAa and Cry1Ac with three H...
November 15, 2017: Transgenic Research
https://www.readbyqxmd.com/read/29142203/mode-of-delivery-and-child-and-adolescent-psychological-well-being-evidence-from-hong-kong-s-children-of-1997-birth-cohort
#11
Cherry Y Leung, Gabriel M Leung, C Mary Schooling
Mode of delivery (vaginal or cesarean section) is thought to affect gut microbiota, which in turn may affect psychological well-being. As such, mode of delivery is potentially a modifiable factor for psychological well-being. Here we examined the association of mode of delivery with child and adolescent psychological well-being. We used multivariable linear regression in a population-representative Hong Kong Chinese birth cohort, "Children of 1997," to examine the adjusted associations of mode of delivery with behavioral problems assessed from parent-reported Rutter score at ~7 (n = 6294) and ~11 years (n = 5598), self-esteem assessed from self-reported Culture-Free Self-Esteem Inventory score at ~11 years (n = 6937) and depressive symptoms assessed from self-reported Patient Health Questionnaire-9 score at ~13 years (n = 5797)...
November 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29139197/survival-prediction-among-nursing-home-residents-a-longitudinal-study
#12
Claudia Kam Yuk Lai, Lily Yuen Wah Ho, Kenny Chi Wing Chin, Enid Wai Yung Kwong
AIM: To determine the survival time and predictors of survival of residents in a nursing home. METHODS: Nursing home residents admitted from June 2008 (when the nursing home started operating) to December 2012 (n = 230) to a new nursing home in Hong Kong were prospectively followed. The predictors of survival in the residents were assessed annually, with the exception of those who did not want to continue with the study, or were hospitalized, discharged from the nursing home or died, to compare changes occurring from 2008 to 2012...
November 15, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/29138955/the-impact-of-palliative-care-training-for-oncologists-and-integrative-palliative-service-in-a-public-funded-hospital-cluster-a-retrospective-cohort-study
#13
Pak-Lun Lam, Tai-Chung Lam, Cheuk-Wai Choi, Anne Wing-Mui Lee, Kwok-Keung Yuen, To-Wai Leung
PURPOSE: Oncological care of advanced cancer patients was provided by multiple departments in Hong Kong. One of these departments, the clinical oncology department (COD), introduced systematic palliative care training for its oncologists since 2002. The COD was recognized as a European Society for Medical Oncology (ESMO) Designated Centre of Integrated Oncology and Palliative Care since 2009. This retrospective cohort study aims to review the impact of integrative training and service on palliative care coverage and outcome...
November 14, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29138015/anti-phase-synchronization-of-influenza-a-h1n1-and-a-h3n2-in-hong-kong-and-countries-in-the-north-temperate-zone
#14
Alice P Y Chiu, Qianying Lin, Edwin Yiu Nam Tang, Daihai He
OBJECTIVES: Influenza affects 10% of the global population annually. Hong Kong is a subtropical city close to the North Temperate Zone (NTZ). Its influenza-associated mortality rates were 27.53, 79.55, 36.94, 48.72 per one million person-years in 2014, 2015, 2016 and January to July 2017 respectively. Our study aims at exploring the temporal patterns of influenza A subtypes both in Hong Kong and the NTZ. METHOD: Weekly reported cases of Influenza A/H1N1 and A/H3N2 from January 2010 to July 2017 were downloaded from the Centre for Health Protection in HK and the FluNet provided by the World Health Organization...
November 11, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29138012/systematic-review-on-reporting-quality-of-randomized-controlled-trials-in-patients-with-hepatitis-b-or-c-in-china
#15
Na Zeng, Cailun Zou, Zhiying He, Hong Ma, Xiaojuan Ou, Hong You, Yuanyuan Kong, Jidong Jia
BACKGROUND: Randomized controlled trails (RCTs) on viral hepatitis in China have been increasing, but few studies have been systematically conducted to evaluate the reporting quality of RCTs in this field. In the present study, we assessed the reporting quality of RCTs on the treatment of hepatitis B or C from 1991 to 2015 in China. METHODS: Articles published between January 1991 and December 2015 were identified via PubMed, Medline, and Embase by using the key words "randomized clinical trials," "treatment," "therapy," "hepatitis B," "HBV," "hepatitis C," "HCV," "China," and "Chinese...
November 11, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29137504/avoidable-hospital-admissions-from-diabetes-complications-in-japan-singapore-hong-kong-and-communities-outside-beijing
#16
Jianchao Quan, Huyang Zhang, Deanette Pang, Brian K Chen, Janice M Johnston, Weiyan Jian, Zheng Yi Lau, Toshiaki Iizuka, Gabriel M Leung, Hai Fang, Kelvin B Tan, Karen Eggleston
Improving the quality of primary care may reduce avoidable hospital admissions. Avoidable admissions for conditions such as diabetes are used as a quality metric in the Health Care Quality Indicators of the Organization for Economic Cooperation and Development (OECD). Using the OECD indicators, we compared avoidable admission rates and spending for diabetes-related complications in Japan, Singapore, Hong Kong, and rural and peri-urban Beijing, China, in the period 2008-14. We found that spending on diabetes-related avoidable hospital admissions was substantial and increased from 2006 to 2014...
November 2017: Health Affairs
https://www.readbyqxmd.com/read/29129269/partial-two-thirds-nephrectomy-in-pigs-a-comparison-of-three-surgical-approaches
#17
Hai-Feng Liu, Wei-Jing Meng, Xiang-Dong Kong, Ge Bai, Hui Li, Jian-Tao Zhang, Hong-Gang Fan, Hong-Bin Wang
Partial (2/3) nephrectomy can be performed via the laparoscopic, retroperitoneal, and transperitoneal approach. Outcomes of the three approaches were compared in this study. 2/3 nephrectomy were performed in 21 healthy Bama miniature pigs (mean bodyweight 20.59±2.78kg). Pigs were divided into three groups: those that underwent 2/3 nephrectomy via laparoscopy (LN group, n=7), the retroperitoneal approach (RN group, n=7), or the transperitoneal approach (TN group, n=7). We monitored pre- and postoperative physiologic parameters, blood cell count, and stress and renal function biomarkers...
November 7, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/29127869/trans-boundary-air-pollution-in-a-city-under-various-atmospheric-conditions
#18
Ming Luo, Xiangting Hou, Yefu Gu, Ngar-Cheung Lau, Steve Hung-Lam Yim
Trans-boundary air pollution (TAP) is a crucial factor affecting air quality, and its contribution may vary over time and differ under various atmospheric conditions. This study firstly applies an integrated statistical scheme to estimate the contributions of TAP and local sources to air pollutants in a city, and then investigate the influences of tropical cyclones (TC) on TAP. Hong Kong is chosen as an example because of its significant and special TAP characteristics. This study focuses on four major air pollutants, namely, respirable and fine suspended particulates (RSP/PM10 and FSP/PM2...
November 8, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29127535/predictors-of-hiv-testing-and-their-influence-on-prep-acceptance-in-men-who-have-sex-with-men-a-cross-sectional-study
#19
Tsz Ho Kwan, Shui Shan Lee
HIV testing is the gateway to biomedical means of prevention and treatment. Identifying predictors of HIV testing is important to inform future preventive interventions. Of 444 men who have sex with men without known HIV infection enrolled in a study in Hong Kong, 64% had ever been HIV-tested. Testers were generally older, better educated, had a higher monthly income, and more likely self-identified as gay. Testers often used Internet and frequented saunas for sex networking, compared with non-testers attending bars, massage centres and public toilets...
November 10, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/29126817/serum-anti-pla2r-antibody-as-a-diagnostic-biomarker-of-idiopathic-membranous-nephropathy-the-optimal-cut-off-value-for-chinese-patients
#20
Yipeng Liu, Xuan Li, Chaoqun Ma, Ping Wang, Ju Liu, Hong Su, Hao Zhuo, Xianglei Kong, Dayu Xu, Dongmei Xu
BACKGROUND: The M-type phospholipase A2 receptor (PLA2R) is a specific target autoantigen identified in idiopathic membranous nephropathy (IMN). The autoantibody against PLA2R (anti-PLA2R) may be used to diagnose IMN. However, the appropriate diagnosis cut-off value for Chinese patients with IMN has not been established. METHODS: In total, 119 patients who underwent renal biopsy (57 patients with IMN and 62 patients with non-IMN glomerulonephritis) and 22 healthy individuals were recruited for our observation study from Qianfoshan Hospital between September 2011 and March 2016...
November 7, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
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