keyword
https://read.qxmd.com/read/38532405/lung-transcriptomics-reveals-the-underlying-mechanism-by-which-aerobic-training-enhances-pulmonary-function-in-chronic-obstructive-pulmonary-disease
#1
JOURNAL ARTICLE
Jian Li, Cai-Tao Chen, Peijun Li, Xiaoyun Zhang, Xiaodan Liu, Weibing Wu, Wei Gu
BACKGROUND: Aerobic training is the primary method of rehabilitation for improving respiratory function in patients with chronic obstructive pulmonary disease (COPD) in remission. However, the mechanism underlying this improvement is not yet fully understood. The use of transcriptomics in rehabilitation medicine offers a promising strategy for uncovering the ways in which exercise training improves respiratory dysfunction in COPD patients. In this study, lung tissue was analyzed using transcriptomics to investigate the relationship between exercise and lung changes...
March 26, 2024: BMC Pulmonary Medicine
https://read.qxmd.com/read/38530051/vessel-and-airway-characteristics-in-one-year-ct-defined-rapid-emphysema-progression-spiromics
#2
JOURNAL ARTICLE
Sarah E Gerard, Timothy M Dougherty, Prashant Nagpal, Dakai Jin, MeiLan K Han, John D Newell, Punam K Saha, Alejandro P Comellas, Christopher B Cooper, David Couper, Spyridon Fortis, Junfeng Guo, Nadia N Hansel, Richard E Kanner, Ella A Kazeroni, Fernando J Martinez, Amin Motahari, Robert Paine Iii, Stephen Rennard, Joyce D Schroeder, Prescott G Woodruff, R Graham Barr, Benjamin M Smith, Eric A Hoffman
Rationale: Rates of emphysema progression vary in chronic obstructive pulmonary disease (COPD), and the relationship with vascular and airway pathophysiology remain unclear. Objective: We sought to determine if indices of peripheral (segmental and beyond) pulmonary arterial (PA) dilation measured via computed tomography (CT) are associated with a 1-year index of emphysema (EI: %voxels<-950HU) progression. Methods: 599 GOLD 0-3 former and never-smokers were evaluated from the SubPopulations and InterMediate Outcome Measures in COPD Study (SPIROMICS) cohort: rapid-emphysema-progressors (RP, n=188; 1-year ΔEI>1%), non-progressors (NP, n=301; 1-year ΔEI±0...
March 26, 2024: Annals of the American Thoracic Society
https://read.qxmd.com/read/38525746/retrospective-analysis-of-the-ventilatory-workload-kinetic-index-during-stability-and-crisis-in-patients-with-asthma-and-copd-in-a-monitored-program
#3
JOURNAL ARTICLE
Rodrigo Muñoz-Cofré, Ramón Pinochet-Urzúa, Mariano Del Sol, Paul Medina-González, Jorge Valenzuela-Vásquez, Gerardo Molina-Vergara, Rodrigo Lizama-Pérez, Máximo Escobar-Cabello
To assess ventilatory evolution through the Ventilatory Workload Kinetic Index (VWKI) in patients with asthma and chronic obstructive pulmonary disease (COPD) during stability and exacerbation. Retrospective analysis. Conducted at the Padre Alberto Hurtado Hospital, Santiago, Chile. Ten patients with asthma and fifty-five with COPD participated. Sixty-five clinical records were reviewed. The VWKI in stability and exacerbation of these patients was extracted. When analyzing the baseline with the peak in both asthma and COPD, there was a significant increase in the VWKI...
March 1, 2024: Geriatrics
https://read.qxmd.com/read/38524091/retrospective-observational-study-to-assess-safety-and-tolerability-of-nebulized-colistin-for-the-treatment-of-patients-with-pneumonia-in-real-world-settings-in-respiratory-icu
#4
JOURNAL ARTICLE
Deepak Talwar, Deepak Prajapat, Surbhi Talwar, Dhruv Talwar
INTRODUCTION: Colistin is used to treat hospital-acquired pneumonia and ventilator-associated pneumonia. However, direct drug deposition at the site of infection may improve its efficacy and reduce systemic exposure. The aim of this study was to assess the safety and tolerability of nebulized colistin among Indian patients diagnosed with pneumonia caused by multidrug-resistant gram-negative bacilli in real-world settings. METHODOLOGY: We retrospectively reviewed the medical records of patients treated with nebulized colistin for pneumonia...
February 2024: Curēus
https://read.qxmd.com/read/38503629/efficacy-of-nemiralisib-in-chronic-obstructive-pulmonary-disease-a-systematic-review
#5
REVIEW
Hongkuan Yang, Shuifeng He, Linbao Liang, Junjie Pan
PURPOSE: Chronic obstructive pulmonary disease (COPD) is a major public health concern. Exacerbation of COPD leads to poor health and frequent episodes of increased systemic and airway inflammation. Immunomodulatory drugs have garnered extensive attention because they may reduce the rate of COPD exacerbation. This review aimed to evaluate the efficacy and safety of nemiralisib in COPD patients. METHODS: Medical databases, including the Cochrane Library, EMBASE, and PubMed, were queried from inception to June 2023 to identify randomized controlled trials (RCTs) on the efficacy of nemiralisib in COPD patients...
March 18, 2024: Clinical Therapeutics
https://read.qxmd.com/read/38503467/improving-breath-detection-from-pulsed-flow-oxygen-sources-using-a-new-nasal-interface
#6
JOURNAL ARTICLE
Cole D Christianson, Efrem Violato, Mozhgan Sabz, Hossein Rouhani, Thomas Waring, Andrew R Martin
BACKGROUND: Patients with COPD and other lung diseases are treated with long-term oxygen therapy (LTOT). Portable oxygen sources are required to administer LTOT while maintaining patient autonomy. Existing portable oxygen equipment has limitations that can hinder patient mobility. A novel nasal interface is presented in this study, aiming to enhance breath detection and triggering efficiency of portable pulsed-flow oxygen devices, thereby improving patient mobility and independence. METHOD: To examine the effectiveness of the new interface, 8 respiratory therapists participated in trials using different oxygen sources (tank with oxygen-conserving device, SimplyGo Mini portable oxygen concentrator [POC], and OxyGo NEXT POC) and breathing types (nasal and oral) while using either the new nasal interface or a standard cannula...
March 19, 2024: Respiratory Care
https://read.qxmd.com/read/38503464/a-network-meta-analysis-on-the-effects-of-different-exercise-types-on-copd-patients
#7
REVIEW
Chengping Jian, Xiangdong Peng, Yuting Yang, Yanli Xu, Liying Wang, Defang Cai
Objective: This study aimed to compare and rank the effects of aerobic exercise (AE), resistance training (RT), endurance training (ET), and high-intensity interval training (HIIT) in chronic obstructive pulmonary disease (COPD) by network meta-analysis (NMA). Methods: PubMed, Cochrane, Embase, and Web of Science were searched to identify randomized controlled trials investigating the effects of exercise training on COPD. The search period began on the date of database establishment and ended in April 8, 2023...
March 19, 2024: Respiratory Care
https://read.qxmd.com/read/38499757/association-of-resistance-training-and-moderate-to-vigorous-physical-activity-with-clinical-outcomes-in-men-with-airflow-limitation-a-nationwide-population-based-study
#8
JOURNAL ARTICLE
Taeyun Kim, Seok Min Hyun, Sun Hye Shin, Yunjoo Im, Yoonju Na, Jong Geol Do, Hye Yun Park, Sunga Kong
Aerobic moderate-to-vigorous physical activity (MVPA) is recommended for individuals with chronic diseases. However, the association between resistance training (RT) in addition to moderate to vigorous physical activity (MVPA) and sleep duration, as well as respiratory symptoms, in patients with chronic obstructive pulmonary disease has not been thoroughly investigated. This population-based cross-sectional study used data from the Korea National Health and Nutrition Examination Survey between 2014 and 2019...
March 18, 2024: Scientific Reports
https://read.qxmd.com/read/38487826/mortality-associated-with-carbapenem-resistance-in-klebsiella-pneumoniae-bloodstream-infection-a-propensity-score-matched-study
#9
JOURNAL ARTICLE
Ling Wang, Chaoying Zeng, Xue Li, Yuqing Li, Zhihua Liu, Jing Hu
OBJECTIVE: Klebsiella pneumoniae are common pathogens causing bloodstream infection (BSI) that increasingly express carbapenem resistance worldwide. To date, no study has precisely investigated the impact of carbapenem resistance in K. pneumoniae (CRKP) BSI on mortality. METHODS: This retrospective study included 87 patients with CRKP BSI and 321 patients with carbapenem-susceptible K. pneumoniae (CSKP) BSI from 2015 to 2020. Propensity score analyses with stabilized inverse probability of treatment weighting (IPTW-S) was applied to balance covariates...
March 15, 2024: Infection Control and Hospital Epidemiology
https://read.qxmd.com/read/38485108/smoking-and-respiratory-diseases-in-patients-with-coronary-microvascular-dysfunction
#10
JOURNAL ARTICLE
Ophir Freund, Aviel Shetrit, Amir Bar-Shai, Lior Zornitzki, Shir Frydman, Ariel Banai, Reut Amar Shamir, Jeremy Ben-Shoshan, Yaron Arbel, Shmuel Banai, Maayan Konigstein
BACKGROUND: Coronary microvascular disease (CMD) is common in patients with and without obstructive coronary artery disease, and is associated with adverse clinical outcomes. Respiratory-related variables are associated with pulmonary and systemic microvascular dysfunction, while evidence regarding their relationship with CMD is limited. We aim to evaluate respiratory-related variables as risk factors of CMD. METHODS: This is an observational, single-center study enrolling consecutive patients undergoing invasive evaluation of coronary microvascular function in the catheterization laboratory...
March 12, 2024: American Journal of Medicine
https://read.qxmd.com/read/38474087/biomolecular-actions-by-intestinal-endotoxemia-in-metabolic-syndrome
#11
REVIEW
Ioannis Alexandros Charitos, Maria Aliani, Pasquale Tondo, Maria Venneri, Giorgio Castellana, Giulia Scioscia, Francesca Castellaneta, Donato Lacedonia, Mauro Carone
Metabolic syndrome (MetS) is a combination of metabolic disorders that concurrently act as factors promoting systemic pathologies such as atherosclerosis or diabetes mellitus. It is now believed to encompass six main interacting conditions: visceral fat, imbalance of lipids (dyslipidemia), hypertension, insulin resistance (with or without impairing both glucose tolerance and fasting blood sugar), and inflammation. In the last 10 years, there has been a progressive interest through scientific research investigations conducted in the field of metabolomics, confirming a trend to evaluate the role of the metabolome, particularly the intestinal one...
February 29, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38468632/acute-exacerbation-of-chronic-obstructive-pulmonary-disease-due-to-carbapenem-resistant-klebsiella-pneumoniae-induced-pneumonia-clinical-features-and-prognostic-factors
#12
JOURNAL ARTICLE
Pengwen Ouyang, Zhijie Zhou, Chanyuan Pan, Peijuan Tang, Sheng Long, Xiangjian Liao, Qiong Liu, Liangyi Xie
PURPOSE: Carbapenem-resistant Klebsiella pneumoniae (CRKP) is closely related to respiratory tract infection. The aim of this study was to investigate the clinical features and prognostic factors of CRKP-induced pneumonia in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) patients. METHODS: A single-centre, retrospective case-control study on COPD patients hospitalized for acute exacerbation and CRKP-induced pneumonia was conducted from January 1, 2016, to December 31, 2022...
2024: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/38468259/quercetin-improves-epithelial-regeneration-from-airway-basal-cells-of-copd-patients
#13
JOURNAL ARTICLE
Elizabeth S McCluskey, Nathan Liu, Abhimaneu Pandey, Nathaniel Marchetti, Steven G Kelsen, Umadevi S Sajjan
BACKGROUND: Airway basal cells (BC) from patients with chronic obstructive pulmonary disease (COPD) regenerate abnormal airway epithelium and this was associated with reduced expression of several genes involved in epithelial repair. Quercetin reduces airway epithelial remodeling and inflammation in COPD models, therefore we examined whether quercetin promotes normal epithelial regeneration from COPD BC by altering gene expression. METHODS: COPD BC treated with DMSO or 1 µM quercetin for three days were cultured at air/liquid interface (ALI) for up to 4 weeks...
March 11, 2024: Respiratory Research
https://read.qxmd.com/read/38467028/sprint-team-approach-yields-rapid-improvement-in-leapfrog-quality-indicators
#14
JOURNAL ARTICLE
Ghazala Q Sharieff, Craig Uejo
GOAL: Patient safety and quality care are two critical areas that every healthcare organization strives to grow and improve upon. At Scripps Health, specific efforts reviewed for this article were implemented to reduce hospital-acquired conditions and hospital readmissions that are components of Centers for Medicare & Medicaid Services programs and Leapfrog Hospital Survey scores. METHODS: Sprint teams, a novel approach to rapidly develop a checklist for lower-performing care improvement areas, were implemented after an internal review of existing tools and an evidence-based literature review...
March 2024: Journal of Healthcare Management / American College of Healthcare Executives
https://read.qxmd.com/read/38460977/predicting-parameters-of-airway-dynamics-generated-from-inspiratory-and-expiratory-plethysmographic-airway-loops-differentiating-subtypes-of-chronic-obstructive-diseases
#15
JOURNAL ARTICLE
Richard Kraemer, Hans-Jürgen Smith, Juergen Reinstaedtler, Sabina Gallati, Heinrich Matthys
BACKGROUND: The plethysmographic shift volume-flow loop (sRaw -loop) measured during tidal breathing allows the determination of several lung function parameters such as the effective specific airway resistance (sReff ), calculated from the ratio of the integral of the resistive aerodynamic specific work of breathing (sWOB) and the integral of the corresponding flow-volume loop. However, computing the inspiratory and expiratory areas of the sRaw -loop separately permits the determination of further parameters of airway dynamics...
March 9, 2024: BMJ Open Respiratory Research
https://read.qxmd.com/read/38455608/functional-capacity-and-quality-of-life-improvement-in-stable-chronic-obstructive-pulmonary-disease-copd-patients-following-physical-exercise-and-chicken-egg-white-supplementation
#16
JOURNAL ARTICLE
Benny Sihombing, Amira P Tarigan, Pandiaman Pandia, Fotarisman Zaluchu, Bintang Ym Sinaga, Nanda S Monica, Ella Rhinsilva, Zulkarnain Zulkarnain
The pillars of comprehensive pulmonary rehabilitation program for chronic obstructive pulmonary disease (COPD) patients include physical exercise and good nutrition. The aim of this study was to evaluate the efficacy of pulmonary rehabilitation, which included physical exercise and chicken egg white supplementation, on the quality of life (QoL) and functional capacity among patients with stable COPD. The COPD patients were enrolled prospectively in this quasi-experimental study and completed a 12-week smartphone-guided home-based physical exercise program that comprised strength and resistance training three times per week for 30 minutes each session...
December 2023: Narra J
https://read.qxmd.com/read/38449006/clinical-characteristics-and-drug-resistance-of-nocardia-in-henan-china-2017-2023
#17
REVIEW
Yungang Han, Meijin Cheng, Zheng Li, Huihui Chen, Shuang Xia, Yue Zhao, Yali Wang, Wenyi He, Wei Wang
BACKGROUND: The aim of this study was to investigate the clinical features of Nocardia infections, antibiotic resistance profile, choice of antibiotics and treatment outcome, among others. In addition, the study compared the clinical and microbiological characteristics of nocardiosis in bronchiectasis patients and non-bronchiectasis patients. METHODS: Detailed clinical data were collected from the medical records of 71 non-duplicate nocardiosis patients from 2017 to 2023 at a tertiary hospital in Zhengzhou, China...
March 6, 2024: Annals of Clinical Microbiology and Antimicrobials
https://read.qxmd.com/read/38444664/development-and-evaluation-of-a-tool-to-optimise-inhaler-selection-prior-to-hospital-discharge-following-an-exacerbation-of-copd
#18
JOURNAL ARTICLE
Evleen Price, Shanaz Ahmad, Malik A Althobiani, Tareq Ayoob, Teresa Burgoyne, Anthony De Soyza, Melissa Dobson, Carlos Echevarria, Graham Martin, Renata Gonçalves Mendes, Anne-Marie Preston, Najib M Rahman, Elizabeth Sapey, Omar S Usmani, John R Hurst
INTRODUCTION: Rates of mortality and re-admission after a hospitalised exacerbation of COPD are high and resistant to change. COPD guidelines do not give practical advice about the optimal selection of inhaled drugs and device in this situation. We hypothesised that a failure to optimise inhaled drug and drug delivery prior to discharge from hospital after an exacerbation would be associated with a modifiable increased risk of re-admission and death. We designed a study to 1) develop a practical inhaler selection tool to use at the point of hospital discharge and 2) implement this tool to understand the potential impact on modifying inhaler prescriptions, clinical outcomes, acceptability to clinicians and patients, and the feasibility of delivering a definitive trial to demonstrate potential benefit...
March 2024: ERJ Open Research
https://read.qxmd.com/read/38440564/evaluation-of-pre-and-post-operative-pulmonary-artery-pressures-in-children-with-adenotonsillar-hypertrophy-and-correlation-with-chronicity-a-prospective-study-on-50-children
#19
JOURNAL ARTICLE
Khushboo Goel, Sanjeev Bhagat, Dinesh Kumar Sharma, Vishav Yadav, Peeyush Verma, Saivi Rajdev
Children with grade III or IV of adenotonsillar hypertrophy especially of a longer duration, may show cardiovascular changes due to mouth breathing. These changes can be detected on doppler echocardiocardiography which can be used as a screening tool. Fifty paediatric patients of grade 3 and 4 adenotonsillar hypertrophy underwent adenotonsillar resection after a pre-operative work up which included doppler echocardiography to measure pulmonary artery pressures. A post-operative doppler echocardiography was done after three months...
February 2024: Indian Journal of Otolaryngology and Head and Neck Surgery
https://read.qxmd.com/read/38412881/traditional-and-advanced-echocardiographic-evaluation-in-chronic-obstructive-pulmonary-disease-the-forgotten-relationship
#20
REVIEW
Mihail Celeski, Andrea Segreti, Dajana Polito, Daniele Valente, Luisa Vicchio, Giuseppe Di Gioia, Gian Paolo Ussia, Raffaele Antonelli Incalzi, Francesco Grigioni
Chronic obstructive pulmonary disease (COPD) is a significant preventable and treatable clinical disorder defined by a persistent, typically progressive airflow obstruction. This disease has a significant negative impact on mortality and morbidity worldwide. However, the complex interaction between the heart and lungs is usually underestimated, necessitating more attention to improve clinical outcomes and prognosis. Indeed, COPD significantly impacts ventricular function, right and left chamber architecture, tricuspid valve functionality, and pulmonary blood vessels...
February 25, 2024: American Journal of Cardiology
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