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https://www.readbyqxmd.com/read/28627948/-renal-transplantations-in-the-centre-for-nephrology-in-szombathely-1976-2016
#1
András Dobos, Erzsébet Ruzsa, Erzsébet Molnár, Gyuláné Szakács, Imre Kulcsár
INTRODUCTION: The organized nephrological care in Szombathely commenced its activities in 1976. AIM: Follow-up of our patients who has undergone a kidney transplantation. METHOD: We used the local and national databases. RESULTS: 213 patients (7 preemptive, 206 dialyzed) had 240 renal transplantations. Only 11 of them were living organ donation. Between 69 transplantations (Tx) were carried out between 1976-1995, and 163 Tx were done in the second 20 years...
June 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28626882/quantitative-proteome-analysis-of-plasma-microparticles-for-the-characterization-of-hcv-induced-hepatic-cirrhosis-and-hepatocellular-carcinoma
#2
Raghda Saad Zaghloul Taleb, Pacint Moez, Doreen Younan, Martin Eisenacher, Matthias Tenbusch, Barbara Sitek, Thilo Bracht
Hepatocellular carcinoma (HCC) is the most common primary malignant liver tumor and a leading cause of cancer-related deaths worldwide. Cirrhosis induced by hepatitis-C virus (HCV) infection is the most critical risk factor for HCC. However, the mechanism of HCV-induced carcinogenesis is not fully understood. Plasma microparticles (PMP) contribute to numerous physiological and pathological processes and contain proteins whose composition correlates to the respective pathophysiological conditions. Given this fact, we analyzed PMP from 22 HCV-induced cirrhosis patients, 16 HCV-positive HCC patients with underlying cirrhosis and 18 healthy controls...
June 19, 2017: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/28626526/efficient-divergent-synthesis-of-new-immunostimulant-4%C3%A2-modified-%C3%AE-galactosylceramide-analogues
#3
Jonas Janssens, Tine Decruy, Koen Venken, Toshiyuki Seki, Simon Krols, Johan Van der Eycken, Moriya Tsuji, Dirk Elewaut, Serge Van Calenbergh
A synthesis strategy for the swift generation of 4″-modified α-galactosylceramide (α-GalCer) analogues is described, establishing a chemical platform to comprehensively investigate the structure-activity relationships (SAR) of this understudied glycolipid part. The strategy relies on a late-stage reductive ring-opening of a p-methoxybenzylidene (PMP) acetal to regioselectively liberate the 4″-OH position. The expediency of this methodology is demonstrated by the synthesis of a small yet diverse set of analogues, which were tested for their ability to stimulate invariant natural killer T-cells (iNKT) in vitro and in vivo...
June 8, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28605985/diagnostic-and-therapeutic-laparoscopy-in-assessment-and-management-of-patients-with-appendiceal-neoplasms
#4
Grace Hwei Ching Tan, Tushar Shamji, Akash Mehta, Kandiah Chandrakumaran, Sanjeev Dayal, Faheez Mohamed, Normal J Carr, Babtunde Rowaiye, Tom Cecil, Rendan J Moran
INTRODUCTION: Radiological imaging often underestimates the extent of low volume peritoneal disease. The benefit of laparoscopy in assessing peritoneal metastases from colorectal and gastric cancer is accepted, but is inconclusive for appendiceal malignancy. We report our experience of diagnostic (DL) and therapeutic laparoscopy (TL) in patients with appendiceal tumours to determine indications and role in assessment and management. METHODS: A retrospective review of a National Peritoneal Malignancy Centre's prospectively maintained database was performed...
June 12, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28604693/genetically-encoding-phosphotyrosine-and-its-nonhydrolyzable-analog-in-bacteria
#5
Xiaozhou Luo, Guangsen Fu, Rongsheng E Wang, Xueyong Zhu, Claudio Zambaldo, Renhe Liu, Tao Liu, Xiaoxuan Lyu, Jintang Du, Weimin Xuan, Anzhi Yao, Sean A Reed, Mingchao Kang, Yuhan Zhang, Hui Guo, Chunhui Huang, Peng-Yu Yang, Ian A Wilson, Peter G Schultz, Feng Wang
Tyrosine phosphorylation is a common protein post-translational modification that plays a critical role in signal transduction and the regulation of many cellular processes. Using a propeptide strategy to increase cellular uptake of O-phosphotyrosine (pTyr) and its nonhydrolyzable analog 4-phosphomethyl-L-phenylalanine (Pmp), we identified an orthogonal aminoacyl-tRNA synthetase-tRNA pair that allows site-specific incorporation of both pTyr and Pmp into recombinant proteins in response to the amber stop codon in Escherichia coli in good yields...
June 12, 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/28599482/an-unusual-case-of-pseudomyxoma-peritonei-associated-with-synchronous-primary-mucinous-tumors-of-the-ovary-and-appendix-a-case-report
#6
Dong Soo Suh, Yong Jung Song, Byung Su Kwon, Sul Lee, Nam Kyung Lee, Kyung Un Choi, Ki Hyung Kim
Pseudomyxoma peritonei (PMP) is a rare disease that usually originates from mucinous neoplasms of the appendix and, less commonly, from extra-appendiceal tumors, but it may also be caused by synchronous primary mucinous tumors of the ovary and appendix. The current study discusses the case of a 73-year-old female who presented with progressively worsening indigestion and abdominal distension. Magnetic resonance imaging of the pelvis revealed a large cystic mass with a thin enhancing septa arising from the right ovary and ascites with scalloping of the liver surface...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28593462/moderators-of-the-effects-of-meaning-centered-group-psychotherapy-in-cancer-survivors-on-personal-meaning-psychological-well-being-and-distress
#7
Karen Holtmaat, Nadia van der Spek, Birgit I Witte, William Breitbart, Pim Cuijpers, Irma M Verdonck-de Leeuw
PURPOSE: There is evidence to support that meaning-centered group psychotherapy for cancer survivors (MCGP-CS) is an effective intervention for improving personal meaning and psychological well-being, as well as reducing psychological distress. In order to investigate which subpopulations MCGP-CS specifically benefits, this explorative study aims to analyze potential sociodemographic, clinical, and psychosocial factors that may moderate the effects. METHODS: Cancer survivors (N = 114) were randomly assigned to MCGP-CS, or care as usual (CAU)...
June 7, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28591173/overinterpretation-is-common-in-pathological-diagnosis-of-appendix-cancer-during-patient-referral-for-oncologic-care
#8
Mark A Valasek, Irene Thung, Esha Gollapalle, Alexey A Hodkoff, Kaitlyn J Kelly, Joel M Baumgartner, Vera Vavinskaya, Grace Y Lin, Ann P Tipps, Mojgan V Hosseini, Andrew M Lowy
CONTEXT: Low-grade appendiceal mucinous neoplasm (LAMN) and appendiceal adenocarcinoma are known to cause the majority of pseudomyxoma peritonei (PMP, i.e. mucinous ascites); however, recognition and proper classification of these neoplasms can be difficult despite established diagnostic criteria. OBJECTIVE: To determine the pathological diagnostic concordance for appendix neoplasia and related lesions during patient referral to an academic medical center specialized in treating patients with PMP...
2017: PloS One
https://www.readbyqxmd.com/read/28587731/prediction-of-clinical-outcome-using-blood-flow-volume-in-the-superior-mesenteric-artery-in-patients-with-pseudomyxoma-peritonei-treated-by-cytoreductive-surgery
#9
A Dohan, M Barral, C Eveno, R Lo Dico, R Kaci, A Pasteur-Rousseau, P Soyer, M Pocard, P Bonnin
BACKGROUND: Pseudomyxoma peritonei (PMP) is a rare carcinomatosis limited to the peritoneal cavity, mainly supplied by the superior mesenteric artery (SMA). The only curative treatment is cytoreductive surgery (CRS) associated with hyperthermic intraperitoneal chemotherapy. This study aimed to evaluate the ability of blood flow volume (BFV) recorded in the SMA using Doppler ultrasonography pre-operatively to predict the extent and resectability of the disease and post-operatively to assess clinical outcome...
May 25, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28584624/the-european-renal-association-european-dialysis-and-transplant-association-registry-annual-report-2014-a-summary
#10
Maria Pippias, Anneke Kramer, Marlies Noordzij, Nikolaos Afentakis, Ramón Alonso de la Torre, Patrice M Ambühl, Manuel I Aparicio Madre, Felipe Arribas Monzón, Anders Åsberg, Marjolein Bonthuis, Encarnación Bouzas Caamaño, Ivan Bubic, Fergus J Caskey, Pablo Castro de la Nuez, Harijs Cernevskis, Maria de Los Ángeles Garcia Bazaga, Jean-Marin des Grottes, Raquel Fernández González, Manuel Ferrer-Alamar, Patrik Finne, Liliana Garneata, Eliezer Golan, James G Heaf, Marc H Hemmelder, Alma Idrizi, Kyriakos Ioannou, Faical Jarraya, Nino Kantaria, Mykola Kolesnyk, Reinhard Kramar, Mathilde Lassalle, Visnja V Lezaic, Frantisek Lopot, Fernando Macario, Ángela Magaz, Angel L Martín de Francisco, Eduardo Martín Escobar, Alberto Martínez Castelao, Wendy Metcalfe, Inmaculada Moreno Alia, Maurizio Nordio, Mai Ots-Rosenberg, Runolfur Palsson, Marina Ratkovic, Halima Resic, Boleslaw Rutkowski, Carmen Santiuste de Pablos, Nurhan Seyahi, María Fernanda Slon Roblero, Viera Spustova, Koenraad J F Stas, María E Stendahl, Olivera Stojceva-Taneva, Evgueniy Vazelov, Edita Ziginskiene, Ziad Massy, Kitty J Jager, Vianda S Stel
Background: This article summarizes the European Renal Association - European Dialysis and Transplant Association Registry's 2014 annual report. It describes the epidemiology of renal replacement therapy (RRT) for end-stage renal disease (ESRD) in 2014 within 35 countries. Methods: In 2016, the ERA-EDTA Registry received data on patients who in 2014 where undergoing RRT for ESRD, from 51 national or regional renal registries. Thirty-two registries provided individual patient level data and 19 provided aggregated patient level data...
April 2017: Clinical Kidney Journal
https://www.readbyqxmd.com/read/28575572/-features-of-vertebral-pain-syndromes-in-older-women-depending-on-the-duration-of-postmenopausal-period-and-bone-mineral-density-indices
#11
T V Orlyk, N V Grygorieva, V V Povoroznyuk
We have analyzed the vertebral pain syndrome (VPS) rate in 2 844 women aged 40-89 years, divided into groups according to the period of life (reproductive, perimenopausal and postmenopausal (PMP)) and evaluated the relationship between VPS frequency and indices of bone mineral density (BMD). It was found that the frequency of VPS during different physiological periods of woman life ranges from 84,1 to 94,4 %, with significant increase when the PMP period is more than 20 years compared with women in reproductive and early postmenopausal periods...
2017: Advances in Gerontology, Uspekhi Gerontologii
https://www.readbyqxmd.com/read/28575080/immunization-of-a-wild-koala-population-with-a-recombinant-chlamydia-pecorum-major-outer-membrane-protein-momp-or-polymorphic-membrane-protein-pmp-based-vaccine-new-insights-into-immune-response-protection-and-clearance
#12
Marion Desclozeaux, Amy Robbins, Martina Jelocnik, Shahneaz Ali Khan, Jon Hanger, Volker Gerdts, Andrew Potter, Adam Polkinghorne, Peter Timms
We assessed the effects of two different single-dose anti-Chlamydia pecorum (C. pecorum) vaccines (containing either Major Outer Membrane Protein (3MOMP) or Polymorphic Membrane Protein (Pmp) as antigens) on the immune response of a group of wild koalas. Both vaccines elicited a systemic humoral response as seen by the production of anti-chlamydial IgG antibodies in more than 90% of vaccinated koalas. A mucosal immune response was also observed, with an increase in Chlamydia-specific mucosal IgG and/or IgA antibodies in some koalas post-vaccination...
2017: PloS One
https://www.readbyqxmd.com/read/28566650/a-convenient-method-for-preparation-of-%C3%AE-imino-carboxylic-acid-derivatives-and-application-to-the-asymmetric-synthesis-of-unnatural-%C3%AE-amino-acid-derivative
#13
Tsubasa Inokuma, Takahisa Jichu, Kodai Nishida, Akira Shigenaga, Akira Otaka
We describe herein a manganese(IV) oxide-mediated oxidation of N-p-methoxyphenyl (PMP)-protected glycine derivatives for the synthesis of α-imino carboxylic acid derivatives. Using this methodology, utilization of unstable glyoxic acid derivatives was avoided. Furthermore, using this methodology we synthesized novel α-imino carboxylic acid derivatives such as α-imino phenyl ester, perfluoroalkyl etsers, imides, and thioester. The asymmetric Mannich reaction of those novel imine derivatives with 1,3-dicarbonyl compound is also described, and the novel α-imino imide gave improved chemical yield and stereoselectivity compared with those obtained by the use of the conventional α-imino ester-type substrate...
2017: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28561944/a-global-bibliometric-analysis-of-otolaryngology-head-and-neck-surgery-literature
#14
T F C Saunders, B C Rymer, K J McNamara
OBJECTIVE: Bibliometrics uses analysis of content and citations of journal articles to quantify trends in published data. We aim to use bibliometric analysis to identify the global contribution by country to the ENT surgical literature over a five-year period. DATA SOURCE: The top 20 countries for number of articles published in surgery and the 11 English Language Otolaryngology surgical journals with the highest impact factors (IF) were included. Numbers of scientific articles per year (2009-2013) per country for each journal were identified through PubMed...
May 31, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28552664/saccharomyces-cerevisiae-cells-lacking-pex3-contain-membrane-vesicles-that-harbor-a-subset-of-peroxisomal-membrane-proteins
#15
Justyna P Wroblewska, Luis Daniel Cruz-Zaragoza, Yuan Wei, Andreas Schummer, Silvia G Chuartzman, Rinse de Boer, Silke Oeljeklaus, Maya Schuldiner, Einat Zalckvar, Bettina Warscheid, Ralf Erdmann, Ida J van der Klei
Pex3 has been proposed to be important for the exit of peroxisomal membrane proteins (PMPs) from the ER, based on the observation that PMPs accumulate at the ER in Saccharomyces cerevisiae pex3 mutant cells. Using a combination of microscopy and biochemical approaches, we show that a subset of the PMPs, including the receptor docking protein Pex14, localizes to membrane vesicles in S. cerevisiae pex3 cells. These vesicles are morphologically distinct from the ER and do not co-sediment with ER markers in cell fractionation experiments...
May 26, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28549831/adenocarcinoma-of-the-appendix-with-extra-appendicular-spread-clinico-surgical-and-histologic-analysis-of-27-cases
#16
Francisco J Morera Ocón, Bruno Camps Vilata, Elena Muñoz Forner, Clara Navarro Campoy, Javier Gallego Plazas, Samuel Navarro Fos
BACKGROUND AND OBJECTIVES: Appendiceal neoplasms with extra-appendiceal spread may show different clinical patterns with pseudomyxoma peritonei (PMP) being one of them. We analyse the results in a series of patients treated in our centre. MATERIAL AND METHODS: Retrospective study of patients operated on for appendiceal peritoneal carcinomatosis from January 2012 to May 2015. RESULTS: Twenty-seven consecutive patients were included. Median age 63 years (26-73); 14 were men...
May 23, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28540829/pseudomyxoma-peritonei-natural-history-and-treatment
#17
Rohin Mittal, Anuradha Chandramohan, Brendan Moran
Pseudomyxoma peritonei (PMP) is an uncommon disease characterized by mucinous ascites, classically originating from a ruptured low grade mucinous neoplasm of the appendix. The natural history of PMP revolves around the "redistribution phenomenon", whereby mucinous tumour cells accumulate at specific sites with relative sparing of the motile small bowel and to a lesser extent other parts of the gastrointestinal tract. Peritoneal tumour accumulates due to gravity and at the sites of peritoneal fluid absorption, namely, the greater and lesser omentum and the under-surface of the diaphragm, particularly on the right...
March 29, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28536339/-a-case-report-on-a-successful-resection-after-folfiri-plus-cetuximab-therapy-for-unresectable-colorectal-cancer-with-multiple-liver-metastases
#18
Min Kanamori, Yasuhiro Kurumiya, Keisuke Mizuno, Ei Sekoguchi, Satoshi Kobayashi, Yasuyuki Fukami, Muneyasu Kiriyama, Hiroki Aoyama, Takashi Oiwa, Kei Miyamura, Takanori Jinno, Yu Nakashima, Makiko Mori
The patient was a 66-year-old woman with a history of right breast cancer 20 years prior. Her chief complaint was hematochezia, and she was diagnosed as having rectal cancer. She underwent laparoscopic high anterior resection. We made a diagnosis of moderately differentiated adenocarcinoma, type 2, 25×20 mm, pMP, pN0, Stage I, KRAS being wild-type. Multiple liver metastases were detected 6 months after the surgery. Tumor contacted with grison. The tumor was not completely resected as evidenced by the small liver remnant volume...
May 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28526747/functional-regions-of-the-peroxin-pex19-necessary-for-peroxisome-biogenesis
#19
Gaurav Agrawal, Helen H Shang, Zhi-Jie Xia, Suresh Subramani
The peroxins Pex19 and Pex3 play an indispensable role in peroxisomal membrane protein (PMP) biogenesis, peroxisome division and inheritance. Pex19 plays multiple roles in these processes, but how these functions relate to the structural organization of the Pex19 domains is unresolved. To this end, using deletion mutants, we mapped the Pex19 regions required for peroxisome biogenesis in the yeast Pichia pastoris. Surprisingly, import-competent peroxisomes still formed when Pex19 domains previously believed to be required for biogenesis were deleted, although the peroxisome size was larger than that in wild-type cells...
May 19, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28518173/simultaneous-quantification-of-n-and-o-glycans-using-a-solid-phase-method
#20
Shuang Yang, Yingwei Hu, Lori Sokoll, Hui Zhang
Glycosylation has a pivotal role in a diverse range of biological activities, modulating the structure and function of proteins. Glycogens coupled to the nitrogen atom (N-linked) of asparagine side chains or to the oxygen atom (O-linked) of serine and threonine side chains represent the two major protein glycosylation forms. N-glycans can be released by glycosidases, whereas O-glycans are often cleaved by chemical reaction. However, it is challenging to combine these enzymatic and chemical reactions in order to analyze both N- and O-glycans...
June 2017: Nature Protocols
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