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https://www.readbyqxmd.com/read/28549831/adenocarcinoma-of-the-appendix-with-extra-appendicular-spread-clinico-surgical-and-histologic-analysis-of-27-cases
#1
Francisco J Morera Ocón, Bruno Camps Vilata, Elena Muñoz Forner, Clara Navarro Campoy, Javier Gallego Plazas, Samuel Navarro Fos
BACKGROUND AND OBJECTIVES: Appendiceal neoplasms with extra-appendiceal spread may show different clinical patterns with pseudomyxoma peritonei (PMP) being one of them. We analyse the results in a series of patients treated in our centre. MATERIAL AND METHODS: Retrospective study of patients operated on for appendiceal peritoneal carcinomatosis from January 2012 to May 2015. RESULTS: Twenty-seven consecutive patients were included. Median age 63 years (26-73); 14 were men...
May 23, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28540829/pseudomyxoma-peritonei-natural-history-and-treatment
#2
Rohin Mittal, Anuradha Chandramohan, Brendan Moran
Pseudomyxoma peritonei (PMP) is an uncommon disease characterized by mucinous ascites, classically originating from a ruptured low grade mucinous neoplasm of the appendix. The natural history of PMP revolves around the "redistribution phenomenon", whereby mucinous tumour cells accumulate at specific sites with relative sparing of the motile small bowel and to a lesser extent other parts of the gastrointestinal tract. Peritoneal tumour accumulates due to gravity and at the sites of peritoneal fluid absorption, namely, the greater and lesser omentum and the under-surface of the diaphragm, particularly on the right...
March 29, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28536339/-a-case-report-on-a-successful-resection-after-folfiri-plus-cetuximab-therapy-for-unresectable-colorectal-cancer-with-multiple-liver-metastases
#3
Min Kanamori, Yasuhiro Kurumiya, Keisuke Mizuno, Ei Sekoguchi, Satoshi Kobayashi, Yasuyuki Fukami, Muneyasu Kiriyama, Hiroki Aoyama, Takashi Oiwa, Kei Miyamura, Takanori Jinno, Yu Nakashima, Makiko Mori
The patient was a 66-year-old woman with a history of right breast cancer 20 years prior. Her chief complaint was hematochezia, and she was diagnosed as having rectal cancer. She underwent laparoscopic high anterior resection. We made a diagnosis of moderately differentiated adenocarcinoma, type 2, 25×20 mm, pMP, pN0, Stage I, KRAS being wild-type. Multiple liver metastases were detected 6 months after the surgery. Tumor contacted with grison. The tumor was not completely resected as evidenced by the small liver remnant volume...
May 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28526747/functional-regions-of-the-peroxin-pex19-necessary-for-peroxisome-biogenesis
#4
Gaurav Agrawal, Helen H Shang, Zhi-Jie Xia, Suresh Subramani
The peroxins Pex19 and Pex3 play an indispensable role in peroxisomal membrane protein (PMP) biogenesis, peroxisome division and inheritance. Pex19 plays multiple roles in these processes, but how these functions relate to the structural organization of the Pex19 domains is unresolved. To this end, using deletion mutants, we mapped the Pex19 regions required for peroxisome biogenesis in the yeast Pichia pastoris. Surprisingly, import-competent peroxisomes still formed when Pex19 domains previously believed to be required for biogenesis were deleted, although the peroxisome size was larger than that in wild-type cells...
May 19, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28518173/simultaneous-quantification-of-n-and-o-glycans-using-a-solid-phase-method
#5
Shuang Yang, Yingwei Hu, Lori Sokoll, Hui Zhang
Glycosylation has a pivotal role in a diverse range of biological activities, modulating the structure and function of proteins. Glycogens coupled to the nitrogen atom (N-linked) of asparagine side chains or to the oxygen atom (O-linked) of serine and threonine side chains represent the two major protein glycosylation forms. N-glycans can be released by glycosidases, whereas O-glycans are often cleaved by chemical reaction. However, it is challenging to combine these enzymatic and chemical reactions in order to analyze both N- and O-glycans...
June 2017: Nature Protocols
https://www.readbyqxmd.com/read/28513785/microbiological-outcomes-from-different-periodontal-maintenance-interventions-a-systematic-review
#6
Patricia Daniela Melchiors Angst, Amanda Finger Stadler, Rui Vicente Oppermann, Sabrina Carvalho Gomes
This study aimed to investigate the differences in the subgingival microbiological outcomes between periodontal patients submitted to a supragingival control (SPG) regimen as compared to subgingival scaling and root planing performed combined with supragingival debridement (SPG + SBG) intervention during the periodontal maintenance period (PMP). A systematic literature search using electronic databases (MEDLINE and EMBASE) was conducted looking for articles published up to August 2016 and independent of language...
May 4, 2017: Brazilian Oral Research
https://www.readbyqxmd.com/read/28500171/platelet-microparticles-infiltrating-solid-tumors-transfer-mirnas-that-suppress-tumor-growth
#7
James V Michael, Jeremy G T Wurtzel, Guang Fen Mao, A Koneti Rao, Mikhail A Kolpakov, Abdelkarim Sabri, Nicholas E Hoffman, Sudarsan Rajan, Dhanendra Tomar, Muniswamy Madesh, Marvin T Nieman, Johnny Yu, Leonard C Edelstein, Jesse W Rowley, Andrew S Weyrich, Lawrence E Goldfinger
Platelet-derived microparticles (PMPs) are associated with enhancement of metastasis and poor cancer outcomes. Circulating PMPs transfer platelet microRNAs (miRNAs) to vascular cells. Solid tumor vasculature is highly permeable, allowing the possibility of PMP-tumor cell interaction. Here we show that PMPs infiltrate solid tumors in humans and mice and transfer platelet-derived RNA, including miRNAs, to tumor cells in vivo and in vitro, resulting in tumor cell apoptosis. MiR-24 was a major species in this transfer...
May 12, 2017: Blood
https://www.readbyqxmd.com/read/28474197/computed-tomography-follow-up-assessment-of-patients-with-low-grade-appendiceal-mucinous-neoplasms-evaluation-of-risk-for-pseudomyxoma-peritonei
#8
Catarina Tiselius, Csaba Kindler, Jayant Shetye, Henry Letocha, Kenneth Smedh
BACKGROUND: Low-grade appendiceal mucinous neoplasms are rare. Both classification and management vary. This study aimed to follow up on patients with a diagnosis of LAMN after primary surgery with computer tomography (CT) scans to examine the risk for the development of pseudomyxoma peritonei (PMP). METHODS: This population-based prospective study investigated patients who underwent appendectomy between 2007 and 2013 and had histology results demonstrating the presence of LAMN...
May 4, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28472926/european-chlamydia-abortus-livestock-isolate-genomes-reveal-unusual-stability-and-limited-diversity-reflected-in-geographical-signatures
#9
H M B Seth-Smith, Leonor Sánchez Busó, M Livingstone, M Sait, S R Harris, K D Aitchison, Evangelia Vretou, V I Siarkou, K Laroucau, K Sachse, D Longbottom, N R Thomson
BACKGROUND: Chlamydia abortus (formerly Chlamydophila abortus) is an economically important livestock pathogen, causing ovine enzootic abortion (OEA), and can also cause zoonotic infections in humans affecting pregnancy outcome. Large-scale genomic studies on other chlamydial species are giving insights into the biology of these organisms but have not yet been performed on C. abortus. Our aim was to investigate a broad collection of European isolates of C. abortus, using next generation sequencing methods, looking at diversity, geographic distribution and genome dynamics...
May 4, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28470541/developing-a-peer-mentorship-program-to-increase-competence-in-clinical-supervision-in-clinical-psychology-doctoral-training-programs
#10
Aleksandra A Foxwell, Beth D Kennard, Cynthia Rodgers, Kristin L Wolfe, Hannah F Cassedy, Anna Thomas
OBJECTIVES: Supervision has recently been recognized as a core competency for clinical psychologists. This recognition of supervision as a distinct competency has evolved in the context of an overall focus on competency-based education and training in health service psychology, and has recently gained momentum. Few clinical psychology doctoral programs offer formal training experiences in providing supervision. METHODS: A pilot peer mentorship program (PMP) where graduate students were trained in the knowledge and practice of supervision was developed...
May 3, 2017: Academic Psychiatry
https://www.readbyqxmd.com/read/28468428/high-speed-fpga-based-phase-measuring-profilometry-architecture
#11
Guomin Zhan, Hongwei Tang, Kai Zhong, Zhongwei Li, Yusheng Shi, Congjun Wang
This paper proposes a high-speed FPGA architecture for the phase measuring profilometry (PMP) algorithm. The whole PMP algorithm is designed and implemented based on the principle of full-pipeline and parallelism. The results show that the accuracy of the FPGA system is comparable with those of current top-performing software implementations. The FPGA system achieves 3D sharp reconstruction using 12 phase-shifting images and completes in 21 ms with 1024 × 768 pixel resolution. To the best of our knowledge, this is the first fully pipelined architecture for PMP systems, and this makes the PMP system very suitable for high-speed embedded 3D shape measurement applications...
May 1, 2017: Optics Express
https://www.readbyqxmd.com/read/28465231/rac1-regulates-sepsis-induced-formation-of-platelet-derived-microparticles-and-thrombin-generation
#12
Yongzhi Wang, Lingtao Luo, Matthias Mörgelin, Henrik Thorlacius
Dysfunctional coagulation aggravates clinical outcome in patients with sepsis. The aim of this study was to define the role of Rac-1 in the formation of platelet-derived microparticles (PMPs) and thrombin generation (TG) in abdominal sepsis. Male C57BL/6 mice underwent cecal ligation and puncture (CLP). Scanning electron microscopy and flow cytometry were used to quantify PMPs. TG was determined by use of a fluorimetric assay. It was found that CLP increased Rac1 activity in platelets, which was abolished by administration of the Rac1 inhibitor NSC23766...
June 10, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28460952/compositional-evaluation-of-selected-agro-industrial-wastes-as-valuable-sources-for-the-recovery-of-complex-carbohydrates
#13
Aleksandra Vojvodić, Draženka Komes, Irena Vovk, Ana Belščak-Cvitanović, Arijana Bušić
Re-utilization of various agro-industrial wastes is of growing importance from many aspects. Considering the variety and complexity of such materials, compositional data and compliant methodology is still undergoing many updates and improvements. Present study evaluated sugar beet pulp (SBP), walnut shell (WS), cocoa bean husk (CBH), onion peel (OP) and pea pods (PP) as potentially valuable materials for carbohydrate recovery. Macrocomponent analyses revealed carbohydrate fraction as the most abundant, dominating in dietary fibres...
November 2016: Food Research International
https://www.readbyqxmd.com/read/28460243/optimal-control-design-of-preparation-pulses-for-contrast-optimization-in-mri
#14
Eric Van Reeth, Hélène Ratiney, Michael Tesch, Denis Grenier, Olivier Beuf, Steffen J Glaser, Dominique Sugny
This work investigates the use of MRI radio-frequency (RF) pulses designed within the framework of optimal control theory for image contrast optimization. The magnetization evolution is modeled with Bloch equations, which defines a dynamic system that can be controlled via the application of the Pontryagin Maximum Principle (PMP). This framework allows the computation of optimal RF pulses that bring the magnetization to a given state to obtain the desired contrast after acquisition. Creating contrast through the optimal manipulation of Bloch equations is a new way of handling contrast in MRI, which can explore the theoretical limits of the system...
April 21, 2017: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/28449606/pseudomyxoma-peritonei-as-a-first-manifestation-of-kras-mutated-urachal-mucinous-cystadenocarcinoma-of-the-bladder-a-case-report
#15
Ksenya V Shelekhova, Alexander S Zhuravlev, Daria D Krylova, Alexey S Konstantinov, Lidia V Shtan, Valeriia A Kheinshtein
Only 28 cases of pseudomyxoma peritonei (PMP) arising from urachal neoplasms have been reported. We report one example of this extremely rare disease with KRAS mutational status in its spectrum of pathology. A 45-year-old woman presented with urachal frankly invasive mucinous cystadenocarcinoma confined to the dome of the bladder, which clinically manifested as PMP and was not detected at the first surgery. The primary tumour was revealed 6 months later because of its recurrence as PMP. Microscopic investigation revealed tubular adenoma and cystadenocarcinoma communicating with the bladder lumen and transitioning from the urachal urothelium to the mucinous epithelium...
April 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28446142/differences-in-peripheral-myelin-antigen-specific-t-cell-responses-and-t-memory-subsets-in-atypical-versus-typical-cidp
#16
M Staudt, J M Diederich, C Meisel, A Meisel, J Klehmet
BACKGROUND: Chronic inflammatory demyelinating polyneuropathy (CIDP) is presented by a large heterogeneity of clinical phenotypes. Around 50% of patients suffer from typical CIDP and show better therapy response than atypical variants. The goal of our study was to search for cellular immunological differences in typical versus atypical CIDP in comparison to controls. METHODS: We evaluated 26 (9 typical, 17 atypical) patients with mainly active-unstable CIDP using clinical and immunological examinations (enzyme-linked immunospot assay ELISPOT, fluorescence-activated cell sorting FACS) in comparison to 28 healthy, age-matched controls (HC)...
April 26, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28443964/effects-of-chronic-exercise-on-endothelial-progenitor-cells-and-microparticles-in-professional-runners
#17
Célia Regina de Oliveira Bittencourt, Maria Cristina de Oliveira Izar, Carolina Nunes França, Valdir Lauro Schwerz, Rui Manuel Dos Santos Póvoa, Francisco Antonio Helfenstein Fonseca
BACKGROUND: The effects of chronic exposure to exercise training on vascular biomarkers have been poorly explored. OBJECTIVE: Our study aimed to compare the amounts of endothelial progenitor cells (EPCs), and endothelial (EMP) and platelet (PMP) microparticles between professional runners and healthy controls. METHODS: Twenty-five half-marathon runners and 24 age- and gender-matched healthy controls were included in the study. EPCs (CD34+/KDR+, CD133+/KDR+, and CD34+/CD133+), EMP (CD51+) and PMP (CD42+/CD31+) were quantified by flow-cytometry...
March 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28442516/in-vitro-study-of-the-thrombogenic-activity-of-platelet-derived-microparticles-from-patients-with-acute-coronary-syndrome
#18
Muyesai Nijiati, Abulijiang Saidaming, Li Guoqing
BACKGROUND: To observe the thrombogenic activity of platelet-derived microparticles (PMPs) in PMP-free plasma from non-coronary artery disease (non-CAD) patients and explore the relationship between PMPs and thrombosis in acute coronary syndrome (ACS) patients. METHODS: Patients with ACS who were diagnosed at the outpatient department of cardiology in the People's Hospital of Xinjiang Uygur Autonomous Region, and non-CAD subjects were enrolled in the study from January 2011 to December 2014...
March 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/28428025/adipokines-as-atherothrombotic-risk-factors-in-obese-subjects-associations-with-haemostatic-markers-and-common-carotid-wall%C3%A2-thickness
#19
É Csongrádi, M Káplár, B Nagy, C A Koch, A Juhász, L Bajnok, Z Varga, I Seres, Z Karányi, M T Magyar, L Oláh, A Facskó, J Kappelmayer, G Paragh
BACKGROUND AND AIMS: Some crucial associations between obesity-related altered adipokine levels and the main factors of atherosclerotic, atherothrombotic processes are not fully known. We analysed the relationships of classic adipokines, namely leptin, resistin, adiponectin, tumour necrosis factor-alpha (TNF-α), interleukin 6 (IL-6) with the markers of platelet activation, including mean platelet volume (MPV), platelet surface/soluble P-selectin, platelet-derived microparticles (PMPs), the parameters of coagulation abnormalities and common carotid intima-media thickness (IMT) in obese patients with or without atherosclerotic comorbidities in comparison to age- and sex-matched controls...
March 8, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/28426742/multiple-components-of-pka-and-tgf-%C3%AE-pathways-are-mutated-in-pseudomyxoma-peritonei
#20
Lilli Saarinen, Pirjo Nummela, Alexandra Thiel, Rainer Lehtonen, Petrus Järvinen, Heikki Järvinen, Lauri A Aaltonen, Anna Lepistö, Sampsa Hautaniemi, Ari Ristimäki
Pseudomyxoma peritonei (PMP) is a subtype of mucinous adenocarcinoma mainly restricted to the peritoneal cavity and most commonly originating from the appendix. The genetic background of PMP is poorly understood and no targeted treatments are currently available for this fatal disease. While RAS signaling pathway is affected in most if not all PMP cases and over half of them also have a mutation in the GNAS gene, other genetic alterations and affected pathways are, to a large degree, poorly known. In this study, we sequenced whole coding genome of nine PMP tumors and paired normal tissues in order to identify additional, commonly mutated genes and signaling pathways affected in PMP...
2017: PloS One
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