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Mirjana V Milinković, Slavenka Janković, Ljiljana Medenica, Miloš Nikolić, Vesna Reljić, Svetlana Popadić, Janko Janković
BACKGROUND AND OBJECTIVES: While most previous surveys on the clinico-epidemiological features of autoimmune bullous diseases (AIBDs) have predominantly focused on a single disease entity or just one disease group, there have been only few studies examining the incidence of various AIBDs. In the present study, we set out to determine the spectrum of AIBDs, to estimate the incidence of the most common AIBDs, and to examine their temporal trends in Central Serbia over a period of 20 years...
October 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
Joan Raouf, Fariborz Mobarrez, Karin Larsson, Per-Johan Jakobsson, Marina Korotkova
Microsomal prostaglandin E2 synthase-1 (mPGES-1) constitutes an essential player of inflammation and is involved in the pathogenesis of rheumatoid arthritis (RA). Platelets participate in the regulation of inflammatory processes by the release of pro-inflammatory mediators and platelet-derived microparticles (PMPs). However, the role of the inducible mPGES-1/PGE2 pathway on platelet functions has not been investigated. Here we report a significant impact of mPGES-1 on platelet functions during inflammation...
October 7, 2016: Clinical Science (1979-)
Bin Liu, Jiaojiao Lu, Chunqing Ai, Bao Zhang, Li Guo, Shuang Song, Beiwei Zhu
Uronic acid-containing polysaccharides (UACPs) including well-known glycosaminoglycans (GAGs) and some non-GAGs exist widely in animal kingdom. Although numerous methods have been established to analyze GAGs, few methods are available for non-GAG UACPs. In the present study, a protocol to identify all kinds of UACPs with repeating disaccharide units of hexosamine and uronic acid was demonstrated, and UACP components in five shellfishes, namely Turritella fortilirata Sowerby (GTF), Batillaria zonalis (GBZ), Nassarius variciferus (GNV), Monodonta labio Linnaeus (GML), and Argopecten irradians Lamarck (BAI) were primarily revealed...
October 11, 2016: Carbohydrate Research
J Czerwiński, P Malanowski, M Kosieradzki, M Jonas, A Jakubowska-Winecka
BACKGROUND: Monitoring of attitudes toward deceased donation gives the general view of the acceptance of this treatment but does not allow for precise prediction of single person's behavior. Consistency of actions and attitudes has many determinants, personal and situational. The idea of this study was to assess and compare relationships between behaviors and attitudes toward postmortem organ donation in single districts and between larger regions of the country (west and east). METHODS: Indicators calculated for the years 1996-2014 included the number of potential deceased donors (per million population [pmp]/y), the number of objections registered in the refusal registry (pmp), and the number and percentage of family refusals to donation...
September 2016: Transplantation Proceedings
Jennifer R Hiscock, Neil J Wells, Jayne A Ede, Philip A Gale, Mark R Sambrook
A series of neutral ditopic and negatively charged, monotopic host molecules have been evaluated for their ability to bind chloride and dihydrogen phosphate anions, and neutral organophosphorus species dimethyl methylphosphonate (DMMP), pinacolyl methylphosphonate (PMP) and the chemical warfare agent (CWA) pinacolyl methylphosphonofluoridate (GD, soman) in organic solvent via hydrogen bonding. Urea, thiourea and boronic acid groups are shown to bind anions and neutral guests through the formation of hydrogen bonds, with the urea and thiourea groups typically exhibiting higher affinity interactions...
October 12, 2016: Organic & Biomolecular Chemistry
Yeqian Huang, Nayef A Alzahrani, Winston Liauw, Thamer B Traiki, David L Morris
BACKGROUND: There is little evidence for the use of early postoperative intraperitoneal chemotherapy (EPIC) in patients with low-grade appendiceal mucinous neoplasms (LAMNs) with pseudomyxoma peritonei (PMP). This study aims to assess the outcomes regarding the use of EPIC in a large cohort of patients with LAMNs with PMP uniformly treated by cytoreductive surgery (CRS) and perioperative intraperitoneal chemotherapy (PIC), all of whom received hyperthermic intraperitoneal chemotherapy (HIPEC), and most of whom also received EPIC...
October 7, 2016: Annals of Surgical Oncology
Vladimir Iashin, Konstantin Chernichenko, Imre Pápai, Timo Repo
A sterically demanding amine, 1,2,2,6,6-pentamethylpiperidine (PMP), forms a highly reactive Lewis acid-base pair with boron trifluoride. This pair reacts with terminal acetylenes to give the products of C(sp)-H borylation, previously unknown tri- and tetraalkynylboron compounds. Trialkynylfluoroborates can serve as surrogates of alkynyltrifluoroborates for C-C coupling reactions. Using aqueous NaOH, PMP can be recovered from its tetrafluoroborate salt, which is formed as a C-H borylation byproduct. Combining the discovered borylation reactivity with the PMP recovery provides a straightforward and atom-efficient approach to synthetically useful alkynylfluoroborates...
October 6, 2016: Angewandte Chemie
Alice Giacomazzi, Maurizio Degan, Stefano Calabria, Alessandra Meneguzzi, Pietro Minuz
Platelet microparticles (PMPs) contribute to thrombogenesis but the effects of antiplatelet drugs on PMPs generation is undefined. The present study investigated the cellular events regulating PMPs shedding, testing in vitro platelet agonists and inhibitors. Platelet-rich plasma from healthy subjects was stimulated with arachidonic acid (AA), U46619, collagen type-I (10 and 1.5 μg/mL), epinephrine, ADP or TRAP-6 and pre-incubated with acetylsalicylic acid (ASA, 100 and 10 μmol/L), SQ-29,548, apyrase, PSB-0739, or eptifibatide...
2016: Frontiers in Pharmacology
Roberto Solazzo, Michele Donati, Licia Tomasi, Filippo Arfini
Agriculture contributes significantly to greenhouse gas (GHG) emissions, accounting for more than 10% of total CO2 emissions in the EU-28 area. The Common Agricultural Policy (CAP) plays an important role in promoting environmentally and climate friendly practices and needs to respond to the new environmental challenges by better integrating its objectives with other EU policies. In this respect, the recent CAP reform 2014-2020 made a further step, making a large part of direct payments conditional on new agricultural practices beneficial for the climate and the environment, i...
September 29, 2016: Science of the Total Environment
Dorothee Twardella, Ulla Raab, Carmelo Perez-Alvarez, Thomas Steffens, Gabriele Bolte, Hermann Fromme
OBJECTIVE: To describe personal music player (PMP) usage among adolescents, sociodemographic determinants and association with audiometric notches. DESIGN: Audiometric evaluation to assess hearing status, and standardized questionnaires to evaluate PMP listening behaviors, leisure noise exposures and self-reported hearing loss symptoms. Sociodemographic information was collected using a parent questionnaire. Noise exposure by PMP usage equivalent for a 40 h week was estimated based on self-reported volume and duration of use...
August 9, 2016: International Journal of Audiology
Yee Cheng Lau, Qinmei Xiong, Andrew D Blann, Gregory Y H Lip
Atrial fibrillation (AF) and chronic kidney disease are closely related, and any associated risk of stroke and thromboembolism due to AF is increased by concurrent renal dysfunction. The mechanism(s) for this include abnormalities in platelets and endothelial cells. We hypothesized relationships between levels of circulating platelet microparticles (PMPs, defined by CD42b), soluble P selectin (both reflecting platelet activation), soluble E-selectin (reflecting endothelial activation) and endothelial/platelet microparticles (EPMPs, defined by CD31) with progressive renal dysfunction...
September 26, 2016: Journal of Thrombosis and Thrombolysis
S Cointe, C Judicone, S Robert, M J Mooberry, P Poncelet, M Wauben, R Nieuwland, N S Key, F Dignat-George, R Lacroix
BACKGROUND: Microparticles are extracellular vesicles resulting from the budding of cellular membranes that have a high potential as emergent biomarkers; however, their clinical relevance is hampered by methodological enumeration concerns and a lack of standardization. Flow cytometry (FCM) remains the most commonly used technique with the best capability to determine the cellular origin of single MPs. However, instruments behave variably depending on which scatter parameter, (Forward (FSC) or Side scatter (SSC)), provides the best resolution to discriminate submicron particles...
September 23, 2016: Journal of Thrombosis and Haemostasis: JTH
Ahmed Mostafa Ahmed Mahmoud, Marwa Mahmoud Hussein, Manar Mohamed Moneer
BACKGROUND: For a long time peritoneal neoplasms were considered beyond surgical intervention and beyond cure, till the concept of cytoreductive surgery (CRS) and adjuvant hyperthermic intraperitoneal chemotherapy (HIPEC) was introduced. However this surgical intervention is technically demanding and associated with considerable postoperative morbidity. OBJECTIVE: To describe the surgical strategy in resection of critical sites loaded by heavy tumor deposits and to evaluate short and long term results of CRS and HIPEC, in a cohort of Egyptian patients with pseudomyxoma peritonei (PMP) from appendiceal origin...
September 19, 2016: Journal of the Egyptian National Cancer Institute
Priyanka Punit Kedia, Gayatri Ravikumar, Suravi Mohanty, Julian Crasta, Elizabeth Vallikad
BACKGROUND: Pseudomyxoma peritonei (PMP) is a rare and poorly understood clinicopathological entity characterized by gelatinous ascites with neoplastic or non-neoplastic mucinous implants in the peritoneum. Although its origin was debated, current evidence in literature favours the appendix as the origin of the disease, over the ovaries. The changing terminologies in the classification of this entity pose diagnostic and management challenges. CASE REPORTS: Herein, we report three cases of PMP in postmenopausal women, their clinical presentation, pathological staging based on the peritoneal tumor deposits and the treatment administered...
October 2016: Journal of Obstetrics and Gynaecology of India
J-B Delhorme, C Honoré, L Benhaim, F Dumont, P Dartigues, C Dromain, M Ducreux, D Elias, D Goéré
INTRODUCTION: Complete cytoreductive surgery (CCRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have dramatically changed the prognosis of patients with pseudomyxoma peritonei (PMP). However, recurrences can still occur and no consensus has been reached regarding their optimal treatments. This study aimed to analyze the patterns of recurrence after CCRS plus HIPEC for PMP and potential subsequent treatments of these lesions. PATIENTS AND METHODS: Between 1992 and 2014, patients who had relapsed after treatment of PMP were selected from a prospective database of 251 patients who had undergone CCRS plus HIPEC with a curative intent...
September 2, 2016: European Journal of Surgical Oncology
Shun Zhang, Qing-Ming Wang, Xian-Ping Ding, Tao Wang, Xue-Mei Mu, Zu-Yi Chen
PURPOSE: Idiopathic Asthenozoospermia (AZS) is a common symptom of male infertility described as reduced forward motility or absence of sperm motility. The PATE1 is generally expressed in male genital tract and related to sperm development, maturation and fertilization. However, the single nucleotide polymorphisms (SNPs) of the PATE1 gene which contribute to AZS were still unknown. For this reason, the possible association between the single nucleotide polymorphisms of the PATE1 gene and idiopathic asthenozoospermia was investigated in this research...
September 1, 2016: Journal of Reproductive Immunology
Sarah Van Lent, Winnok H De Vos, Heather Huot Creasy, Patricia X Marques, Jacques Ravel, Daisy Vanrompay, Patrik Bavoil, Ru-Ching Hsia
The polymorphic membrane protein (Pmp) paralogous families of Chlamydia trachomatis, Chlamydia pneumoniae and Chlamydia abortus are putative targets for Chlamydia vaccine development. To determine whether this is also the case for Pmp family members of C. psittaci, we analyzed transcription levels, protein production and localization of several Pmps of C. psittaci. Pmp expression profiles were characterized using quantitative real-time PCR (RT-qPCR), immunofluorescence (IF) and immuno-electron microscopy (IEM) under normal and stress conditions...
2016: PloS One
S M Ayub-Ferreira, J D Souza, D R Almeida, B Biselli, M S Avila, A S Colafranceschi, B Stefanello, B M Carvalho, C A Polanczyk, D R Galantini, E A Bocchi, E G Chamlian, E M Hojaij, F A Gaiotto, F A Pinton, F B Jatene, Fja Ramires, F A Atik, F Figueira, F Bacal, Frbg Galas, F S Brito, G E Conceição-Souza, Gca Ribeiro, Pinheiro Ja, J M Souza, J M Rossi, Jlc Lima, J C Mejía, J R Fernandes, L Baumworcel, Laz Moura, L A Hajjar, L Beck-da-Silva, Lep Rohde, Lfbc Seguro, M L Pinheiro, M Park, M R Fernandes, M W Montera, Msl Alves, Wanderley Mrb, N Hossne, Pmp Fernandes, P Lemos, R O Schneidewind, R B Uchoa, R Honorato, S Mangini, Snrs Falcão, Sav Lopes, Tmv Strabelli, Tcf Guimarães, Tcgf Campanili, V S Issa
No abstract text is available yet for this article.
August 2016: Arquivos Brasileiros de Cardiologia
Natalia Cernei, Zuzana Lackova, Roman Guran, David Hynek, Jiri Skladanka, Pavel Horky, Ondrej Zitka, Vojtech Adam
The presence of biogenic amines is a hallmark of degraded food and its products. Herein, we focused on the utilization of magnetic nanoparticles off-line coupled with ion exchange chromatography with post-column ninhydrin derivatization and Vis detection for histamine (Him) separation and detection. Primarily, we described the synthesis of magnetic nanoparticles with nanomaghemite core (γ-Fe₂O₃) functionalized with titanium dioxide and, then, applied these particles to specific isolation of Him. To obtain further insight into interactions between paramagnetic particles' (PMP) surface and Him, a scanning electron microscope was employed...
2016: International Journal of Environmental Research and Public Health
Jason M Foster, Richard L Sleightholm, Steve Wahlmeier, Brian Loggie, Poonam Sharma, Asish Patel
BACKGROUND: Disseminated peritoneal adenomucinosis (DPAM) patients often have a history of appendectomy with identification of an incidental mucinous neoplasm (low-grade appendiceal mucinous neoplasm (LAMN)). The rate of developing DPAM is not well established. METHODS: Twenty-two patients with incidental LAMN were identified and monitored with cancer markers and CT every 4-6 months. Laparoscopy with peritoneal washing was performed in patients either in the event of radiographic disease or after 12 months in absence of radiographic disease...
2016: World Journal of Surgical Oncology
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