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https://www.readbyqxmd.com/read/28718063/new-insights-on-platelets-and-platelet-derived-microparticles-in-systemic-lupus-erythematosus
#1
REVIEW
Marc Scherlinger, Vanja Sisirak, Christophe Richez, Estibaliz Lazaro, Pierre Duffau, Patrick Blanco
PURPOSE OF REVIEW: Current knowledge on the role of platelets and platelet-derived microparticles (PMPs) on the immune system has been fast-growing. Systemic lupus erythematosus (SLE) is a systemic auto-immune disorder characterized by a loss of tolerance toward nuclear auto-antigens. Although recent studies allowed a better understanding of SLE pathogenesis, there is an urgent need for the development of new treatments and the identification of new biomarkers to assess the disease activity...
August 2017: Current Rheumatology Reports
https://www.readbyqxmd.com/read/28708640/is-cleft-severity-correlated-with-intrinsic-growth-pattern-observation-from-unoperated-adult-patients-with-submucous-cleft-palate
#2
Congcong Cao, Xue Xu, Bing Shi, Qian Zheng, Jingtao Li
OBJECTIVE: This study aimed to evaluate the craniofacial morphology of unoperated adult submucous cleft palate (SMCP) patients and to explore the possible correlation between the intrinsic growth insufficiency of the maxillofacial complex and the severity of the cleft. MATERIALS AND METHODS: A total of 20 unoperated SMCP patients, 20 unoperated overt cleft palate (OCP) patients, and 32 normal controls, ages between 18 and 30, were included for cephalometric analysis...
July 13, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28688787/retrospective-analysis-of-predictors-of-proficient-power-mobility-in-young-children-with-severe-motor-impairments
#3
Shelley R H Mockler, Irene R McEwen, Maria A Jones
OBJECTIVE: The primary objective was to determine if (a) child characteristics, (b) maternal education, (c) intervention parameters, (d) type of wheelchair control mechanism, or a combination of these variables, were associated with proficient power mobility skills in children with severe motor impairments aged 14 to 30 months. The secondary purpose was to determine if performance on the Wheelchair Skills Checklist (WSC) was associated with performance on the Powered Mobility Program (PMP)...
July 5, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28687762/x-ray-snapshots-of-a-pyridoxal-enzyme-a-catalytic-mechanism-involving-concerted-1-5-hydrogen-sigmatropy-in-methionine-%C3%AE-lyase
#4
Dan Sato, Tomoo Shiba, Tsuyoshi Karaki, Wataru Yamagata, Tomoyoshi Nozaki, Takashi Nakazawa, Shigeharu Harada
Pyridoxal 5'-phosphate (PLP)-enzymes are essentially involved in amino acid and amine metabolism of a wide variety of organisms. Despite their extensive biochemical studies, there are little evidence and structural data to comprehensively elaborate the catalytic mechanism. We obtained X-ray snapshots of l-methionine γ-lyase from Entamoeba histolytica (EhMGL), a PLP-enzyme catalyzing the γ-elimination reaction of methionine. Here, we suggest a catalytic mechanism of EhMGL by using the X-ray snapshots covering all stages of this multistep catalysis reaction...
July 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28677239/microbial-community-structure-and-soil-ph-correspond-to-methane-production-in-arctic-alaska-soils
#5
Robert Wagner, Donatella Zona, Walter Oechel, David Lipson
While there is no doubt that biogenic methane production in the Arctic is an important aspect of global methane emissions, the relative roles of microbial community characteristics and soil environmental conditions in controlling Arctic methane emissions remains uncertain. Here, relevant methane-cycling microbial groups were investigated at two remote Arctic sites with respect to soil potential methane production (PMP). Percent abundances of methanogens and iron-reducing bacteria correlated with increased PMP, while methanotrophs correlated with decreased PMP...
July 5, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28672083/bleaching-earths-as-powerful-additives-for-ru-catalyzed-self-metathesis-of-non-refined-methyl-oleate-at-pilot-scale
#6
Marc Mauduit, Jessica Allard, Yann Raoul, Idriss Curbet, Fabien Tripoteau, Sophie Sambou, Guillaume Chollet, Frédéric Caijo, Christophe Crévisy, Olivier Baslé
A practical and cost-effective ruthenium-catalyzed self-metathesis of non-refined methyl oleate (85%) derived from Very High Oleic Sunflower Oils (VHOSO) was demonstrated at pilot scale using a robust and kg-scale commercially available SIPr-M71 pre-catalyst. The simple addition of 1 wt% bleaching earths (Tonsil 110FF) to a thermally pretreated oil could efficiently prevent catalyst deactivation. Remarkably, without the need for filtration, the catalytic system was able to achieve a turnover number of more than 744000 at a catalyst loading of only 1 ppm...
July 3, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28669287/prevalence-of-psychotherapy-surrounding-initiation-of-psychotropic-polypharmacy-in-the-medicaid-insured-population-1999-2010
#7
Juan M Hincapie-Castillo, Xinyue Liu, Regina Bussing, Almut G Winterstein
OBJECTIVE: This research aimed to quantify the prevalence of psychotherapy among Medicaid-insured patients within six months of initiating psychotropic medication polypharmacy (PMP). METHODS: Using the Medicaid Analytic eXtract database for 29 states from 1999 to 2010, investigators established ten two-year cohorts of pediatric and adult patients who received two or more psychotropic drugs with a 45-day overlapping days' supply. Among PMP initiators, the prevalence of psychotherapy services, identified from encounter claims via Current Procedural Terminology and Healthcare Common Procedure Coding System codes, was calculated for the six months before and the six months after initiation of PMP...
July 3, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/28669046/anticoagulant-rodenticide-exposure-and-toxicosis-in-four-species-of-birds-of-prey-in-massachusetts-usa-2012-2016-in-relation-to-use-of-rodenticides-by-pest-management-professionals
#8
Maureen Murray
Restrictions on second-generation anticoagulant rodenticides (SGARs) in the United States, which were partially implemented in 2011, prohibit the sale of SGAR products through general consumer outlets to minimize use by non-professional or non-agricultural applicators. This study analyzed liver tissue from four species of birds of prey admitted to a wildlife clinic in Massachusetts, USA, from 2012-2016 for residues of anticoagulant rodenticides (ARs). Ninety-four birds were analyzed; 16 were symptomatic for AR toxicosis, and 78 asymptomatic...
July 1, 2017: Ecotoxicology
https://www.readbyqxmd.com/read/28658075/evaluation-of-the-official-match-external-load-in-soccer-players-with-cerebral-palsy
#9
J Yanci, D Castillo, A Iturricastillo, R Reina
The aims of this study were to analyze the official match external loads (i.e. total distance [TD], distance covered at different speeds, accelerations, decelerations, player load [PL], peak metabolic power [PMP] and changes of direction [CODs]) of football players with cerebral palsy (CP), and to determine the external loads according to playing time (i.e. < 20 min, 20-40 min and > 40 min). The external load of thirty-one international football players with CP (23.0 ± 6.6 years; 69.1 ± 9.0 kg; 174...
June 22, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28627948/-renal-transplantations-in-the-centre-for-nephrology-in-szombathely-1976-2016
#10
András Dobos, Erzsébet Ruzsa, Erzsébet Molnár, Gyuláné Szakács, Imre Kulcsár
INTRODUCTION: The organized nephrological care in Szombathely commenced its activities in 1976. AIM: Follow-up of our patients who has undergone a kidney transplantation. METHOD: We used the local and national databases. RESULTS: 213 patients (7 preemptive, 206 dialyzed) had 240 renal transplantations. Only 11 of them were living organ donation. Between 69 transplantations (Tx) were carried out between 1976-1995, and 163 Tx were done in the second 20 years...
June 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28626882/quantitative-proteome-analysis-of-plasma-microparticles-for-the-characterization-of-hcv-induced-hepatic-cirrhosis-and-hepatocellular-carcinoma
#11
Raghda Saad Zaghloul Taleb, Pacint Moez, Doreen Younan, Martin Eisenacher, Matthias Tenbusch, Barbara Sitek, Thilo Bracht
PURPOSE: Hepatocellular carcinoma (HCC) is the most common primary malignant liver tumor and a leading cause of cancer-related deaths worldwide. Cirrhosis induced by hepatitis-C virus (HCV) infection is the most critical risk factor for HCC. However, the mechanism of HCV-induced carcinogenesis is not fully understood. Plasma microparticles (PMP) contribute to numerous physiological and pathological processes and contain proteins whose composition correlates to the respective pathophysiological conditions...
June 19, 2017: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/28626526/efficient-divergent-synthesis-of-new-immunostimulant-4%C3%A2-modified-%C3%AE-galactosylceramide-analogues
#12
Jonas Janssens, Tine Decruy, Koen Venken, Toshiyuki Seki, Simon Krols, Johan Van der Eycken, Moriya Tsuji, Dirk Elewaut, Serge Van Calenbergh
A synthesis strategy for the swift generation of 4″-modified α-galactosylceramide (α-GalCer) analogues is described, establishing a chemical platform to comprehensively investigate the structure-activity relationships (SAR) of this understudied glycolipid part. The strategy relies on a late-stage reductive ring-opening of a p-methoxybenzylidene (PMP) acetal to regioselectively liberate the 4″-OH position. The expediency of this methodology is demonstrated by the synthesis of a small yet diverse set of analogues, which were tested for their ability to stimulate invariant natural killer T-cells (iNKT) in vitro and in vivo...
June 8, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28605985/diagnostic-and-therapeutic-laparoscopy-in-assessment-and-management-of-patients-with-appendiceal-neoplasms
#13
Grace Hwei Ching Tan, Tushar Shamji, Akash Mehta, Kandiah Chandrakumaran, Sanjeev Dayal, Faheez Mohamed, Normal J Carr, Babtunde Rowaiye, Tom Cecil, Rendan J Moran
INTRODUCTION: Radiological imaging often underestimates the extent of low volume peritoneal disease. The benefit of laparoscopy in assessing peritoneal metastases from colorectal and gastric cancer is accepted, but is inconclusive for appendiceal malignancy. We report our experience of diagnostic (DL) and therapeutic laparoscopy (TL) in patients with appendiceal tumours to determine indications and role in assessment and management. METHODS: A retrospective review of a National Peritoneal Malignancy Centre's prospectively maintained database was performed...
June 12, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28604693/genetically-encoding-phosphotyrosine-and-its-nonhydrolyzable-analog-in-bacteria
#14
Xiaozhou Luo, Guangsen Fu, Rongsheng E Wang, Xueyong Zhu, Claudio Zambaldo, Renhe Liu, Tao Liu, Xiaoxuan Lyu, Jintang Du, Weimin Xuan, Anzhi Yao, Sean A Reed, Mingchao Kang, Yuhan Zhang, Hui Guo, Chunhui Huang, Peng-Yu Yang, Ian A Wilson, Peter G Schultz, Feng Wang
Tyrosine phosphorylation is a common protein post-translational modification that plays a critical role in signal transduction and the regulation of many cellular processes. Using a propeptide strategy to increase cellular uptake of O-phosphotyrosine (pTyr) and its nonhydrolyzable analog 4-phosphomethyl-L-phenylalanine (Pmp), we identified an orthogonal aminoacyl-tRNA synthetase-tRNA pair that allows site-specific incorporation of both pTyr and Pmp into recombinant proteins in response to the amber stop codon in Escherichia coli in good yields...
June 12, 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/28599482/an-unusual-case-of-pseudomyxoma-peritonei-associated-with-synchronous-primary-mucinous-tumors-of-the-ovary-and-appendix-a-case-report
#15
Dong Soo Suh, Yong Jung Song, Byung Su Kwon, Sul Lee, Nam Kyung Lee, Kyung Un Choi, Ki Hyung Kim
Pseudomyxoma peritonei (PMP) is a rare disease that usually originates from mucinous neoplasms of the appendix and, less commonly, from extra-appendiceal tumors, but it may also be caused by synchronous primary mucinous tumors of the ovary and appendix. The current study discusses the case of a 73-year-old female who presented with progressively worsening indigestion and abdominal distension. Magnetic resonance imaging of the pelvis revealed a large cystic mass with a thin enhancing septa arising from the right ovary and ascites with scalloping of the liver surface...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28593462/moderators-of-the-effects-of-meaning-centered-group-psychotherapy-in-cancer-survivors-on-personal-meaning-psychological-well-being-and-distress
#16
Karen Holtmaat, Nadia van der Spek, Birgit I Witte, William Breitbart, Pim Cuijpers, Irma M Verdonck-de Leeuw
PURPOSE: There is evidence to support that meaning-centered group psychotherapy for cancer survivors (MCGP-CS) is an effective intervention for improving personal meaning and psychological well-being, as well as reducing psychological distress. In order to investigate which subpopulations MCGP-CS specifically benefits, this explorative study aims to analyze potential sociodemographic, clinical, and psychosocial factors that may moderate the effects. METHODS: Cancer survivors (N = 114) were randomly assigned to MCGP-CS, or care as usual (CAU)...
June 7, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28591173/overinterpretation-is-common-in-pathological-diagnosis-of-appendix-cancer-during-patient-referral-for-oncologic-care
#17
Mark A Valasek, Irene Thung, Esha Gollapalle, Alexey A Hodkoff, Kaitlyn J Kelly, Joel M Baumgartner, Vera Vavinskaya, Grace Y Lin, Ann P Tipps, Mojgan V Hosseini, Andrew M Lowy
CONTEXT: Low-grade appendiceal mucinous neoplasm (LAMN) and appendiceal adenocarcinoma are known to cause the majority of pseudomyxoma peritonei (PMP, i.e. mucinous ascites); however, recognition and proper classification of these neoplasms can be difficult despite established diagnostic criteria. OBJECTIVE: To determine the pathological diagnostic concordance for appendix neoplasia and related lesions during patient referral to an academic medical center specialized in treating patients with PMP...
2017: PloS One
https://www.readbyqxmd.com/read/28587731/prediction-of-clinical-outcome-using-blood-flow-volume-in-the-superior-mesenteric-artery-in-patients-with-pseudomyxoma-peritonei-treated-by-cytoreductive-surgery
#18
A Dohan, M Barral, C Eveno, R Lo Dico, R Kaci, A Pasteur-Rousseau, P Soyer, M Pocard, P Bonnin
BACKGROUND: Pseudomyxoma peritonei (PMP) is a rare carcinomatosis limited to the peritoneal cavity, mainly supplied by the superior mesenteric artery (SMA). The only curative treatment is cytoreductive surgery (CRS) associated with hyperthermic intraperitoneal chemotherapy. This study aimed to evaluate the ability of blood flow volume (BFV) recorded in the SMA using Doppler ultrasonography pre-operatively to predict the extent and resectability of the disease and post-operatively to assess clinical outcome...
May 25, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28584624/the-european-renal-association-european-dialysis-and-transplant-association-registry-annual-report-2014-a-summary
#19
Maria Pippias, Anneke Kramer, Marlies Noordzij, Nikolaos Afentakis, Ramón Alonso de la Torre, Patrice M Ambühl, Manuel I Aparicio Madre, Felipe Arribas Monzón, Anders Åsberg, Marjolein Bonthuis, Encarnación Bouzas Caamaño, Ivan Bubic, Fergus J Caskey, Pablo Castro de la Nuez, Harijs Cernevskis, Maria de Los Ángeles Garcia Bazaga, Jean-Marin des Grottes, Raquel Fernández González, Manuel Ferrer-Alamar, Patrik Finne, Liliana Garneata, Eliezer Golan, James G Heaf, Marc H Hemmelder, Alma Idrizi, Kyriakos Ioannou, Faical Jarraya, Nino Kantaria, Mykola Kolesnyk, Reinhard Kramar, Mathilde Lassalle, Visnja V Lezaic, Frantisek Lopot, Fernando Macario, Ángela Magaz, Angel L Martín de Francisco, Eduardo Martín Escobar, Alberto Martínez Castelao, Wendy Metcalfe, Inmaculada Moreno Alia, Maurizio Nordio, Mai Ots-Rosenberg, Runolfur Palsson, Marina Ratkovic, Halima Resic, Boleslaw Rutkowski, Carmen Santiuste de Pablos, Nurhan Seyahi, María Fernanda Slon Roblero, Viera Spustova, Koenraad J F Stas, María E Stendahl, Olivera Stojceva-Taneva, Evgueniy Vazelov, Edita Ziginskiene, Ziad Massy, Kitty J Jager, Vianda S Stel
Background: This article summarizes the European Renal Association - European Dialysis and Transplant Association Registry's 2014 annual report. It describes the epidemiology of renal replacement therapy (RRT) for end-stage renal disease (ESRD) in 2014 within 35 countries. Methods: In 2016, the ERA-EDTA Registry received data on patients who in 2014 where undergoing RRT for ESRD, from 51 national or regional renal registries. Thirty-two registries provided individual patient level data and 19 provided aggregated patient level data...
April 2017: Clinical Kidney Journal
https://www.readbyqxmd.com/read/28575572/-features-of-vertebral-pain-syndromes-in-older-women-depending-on-the-duration-of-postmenopausal-period-and-bone-mineral-density-indices
#20
T V Orlyk, N V Grygorieva, V V Povoroznyuk
We have analyzed the vertebral pain syndrome (VPS) rate in 2 844 women aged 40-89 years, divided into groups according to the period of life (reproductive, perimenopausal and postmenopausal (PMP)) and evaluated the relationship between VPS frequency and indices of bone mineral density (BMD). It was found that the frequency of VPS during different physiological periods of woman life ranges from 84,1 to 94,4 %, with significant increase when the PMP period is more than 20 years compared with women in reproductive and early postmenopausal periods...
2017: Advances in Gerontology, Uspekhi Gerontologii
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