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https://www.readbyqxmd.com/read/28801246/time-optimal-control-strategies-in-sir-epidemic-models
#1
Luca Bolzoni, Elena Bonacini, Cinzia Soresina, Maria Groppi
We investigate the time-optimal control problem in SIR (Susceptible-Infected-Recovered) epidemic models, focusing on different control policies: vaccination, isolation, culling, and reduction of transmission. Applying the Pontryagins Minimum Principle (PMP) to the unconstrained control problems (i.e. without costs of control or resource limitations), we prove that, for all the policies investigated, only bang-bang controls with at most one switch are admitted. When a switch occurs, the optimal strategy is to delay the control action some amount of time and then apply the control at the maximum rate for the remainder of the outbreak...
August 8, 2017: Mathematical Biosciences
https://www.readbyqxmd.com/read/28789719/meaning-of-life-representation-of-death-and-their-association-with-psychological-distress
#2
Ines Testoni, Giulia Sansonetto, Lucia Ronconi, Maddalena Rodelli, Gloria Baracco, Luigi Grassi
OBJECTIVE: This paper presents a two-phase cross-sectional study aimed at examining the possible mitigating role of perceived meaning of life and representation of death on psychological distress, anxiety, and depression. METHOD: The first phase involved 219 healthy participants, while the second encompassed 30 cancer patients. Each participant completed the Personal Meaning Profile (PMP), the Testoni Death Representation Scale (TDRS), the Hospital Anxiety and Depression Scale (HADS), and the Distress Thermometer (DT)...
August 9, 2017: Palliative & Supportive Care
https://www.readbyqxmd.com/read/28773178/thin-film-coated-plastic-wrap-for-food-packaging
#3
Hsin-Yu Wu, Ting-Xuan Liu, Chia-Hsun Hsu, Yun-Shao Cho, Zhi-Jia Xu, Shu-Chuan Liao, Bo-Han Zeng, Yeu-Long Jiang, Shui-Yang Lien
In this study, the antimicrobial property and food package capability of polymethylpentene (PMP) substrate with silicon oxdie (SiOx) and organic silicon (SiCxHy) stacked layers deposited by an inductively coupled plasma chemical vapor deposition system were investigated. The experimental results show that the stacked pair number of SiOx/SiCxHy on PMP is limited to three pairs, beyond which the films will crack and cause package failure. The three-pair SiOx/SiCxHy on PMP shows a low water vapor transmission rate of 0...
July 18, 2017: Materials
https://www.readbyqxmd.com/read/28755910/reprint-of-fast-and-sensitive-in-vivo-studies-under-controlled-environmental-conditions-to-substitute-long-term-field-trials-with-genetically-modified-plants
#4
Patricia Horn, André Schlichting, Christel Baum, Ute Hammesfahr, Sören Thiele-Bruhn, Peter Leinweber, Inge Broer
We introduce an easy, fast and effective method to analyze the influence of genetically modified (GM) plants on soil and model organisms in the laboratory to substitute laborious and time consuming field trials. For the studies described here we focused on two GM plants of the so-called 3rd generation: GM plants producing pharmaceuticals (PMP) and plant made industrials (PMI). Cyanophycin synthetase (cphA) was chosen as model for PMI and Choleratoxin B (CTB) as model for PMP. The model genes are expressed in transgenic roots of composite Vicia hirsuta plants grown in petri dishes for semi-sterile growth or small containers filled with non-sterile soil...
July 26, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28751222/the-use-of-a-composite-synthetic-mesh-in-the-vicinity-of-bowel-for-repair-and-prophylaxis-of-parastomal-hernias-does-it-increase-the-risk%C3%A2-of-short-term-infective-complications
#5
Zhaowei Zhou, Amarvir Bilkhu, Suhail Anwar
AIMS: The use of synthetic meshes in potentially infected operative fields such as in the vicinity of large bowel, is controversial. This study describes our experience with the use of a synthetic composite mesh for prophylaxis and repair of parastomal hernias. METHODS: Data were collected retrospectively over a 7-year period from 2008 to 2015. An IPOM (DynaMesh™) was used either during the formation of the stoma to reinforce the abdominal wall around the stoma or during the surgical repair of existing parastomal hernias, using keyhole or sandwich technique...
July 24, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28746986/the-histopathological-classification-diagnosis-and-differential-diagnosis-of-mucinous-appendiceal-neoplasms-appendiceal-adenocarcinomas-and-pseudomyxoma-peritonei
#6
REVIEW
Norman J Carr, Frederic Bibeau, Robert F Bradley, Peggy Dartigues, Roger M Feakins, Kim R Geisinger, Xianyong Gui, Sylvie Isaac, Massimo Milione, Joseph Misdraji, Reetesh K Pai, Manuel Rodriguez-Justo, Leslie H Sobin, Marie-Louise F van Velthuysen, Rhonda K Yantiss
The vermiform appendix is the primary site of several distinctive benign and malignant neoplasms. Some can produce the clinical syndrome of pseudomyxoma peritonei (PMP). A consensus on their terminology was reached by an international panel of pathologists and clinicians working under the auspices of the Peritoneal Surface Oncology Group International (PSOGI) and this review discusses the application of the PSOGI classification to routine reporting. We discuss diagnosis and differential diagnosis together with implications for patient management, covering low-grade appendiceal mucinous neoplasms, high-grade appendiceal mucinous neoplasms, serrated polyps, adenomas, and adenocarcinomas...
July 26, 2017: Histopathology
https://www.readbyqxmd.com/read/28745771/activation-of-the-p-h-bond-by-a-frustrated-lewis-pair-and-its-application-in-catalytic-z-selective-hydrophosphonylation-of-terminal-ynones
#7
Yizhen Liu, Xiaoting Fan, Zhen Hua Li, Huadong Wang
The frustrated Lewis pair (FLP) comprised of B(C6F5)3 and 1,2,2,6,6-pentamethylpiperidine (PMP) can efficiently catalyze Z-selective hydrophosphonylation of terminal ynones with a Z/E selectivity of up to 20 : 1. Mechanistic studies suggest that the trans arrangement of the phosphite nucleophilic attack and hydrogen bond formation on the alkyne moiety is responsible for the observed Z-selectivity.
July 26, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28718063/new-insights-on-platelets-and-platelet-derived-microparticles-in-systemic-lupus-erythematosus
#8
REVIEW
Marc Scherlinger, Vanja Sisirak, Christophe Richez, Estibaliz Lazaro, Pierre Duffau, Patrick Blanco
PURPOSE OF REVIEW: Current knowledge on the role of platelets and platelet-derived microparticles (PMPs) on the immune system has been fast-growing. Systemic lupus erythematosus (SLE) is a systemic auto-immune disorder characterized by a loss of tolerance toward nuclear auto-antigens. Although recent studies allowed a better understanding of SLE pathogenesis, there is an urgent need for the development of new treatments and the identification of new biomarkers to assess the disease activity...
August 2017: Current Rheumatology Reports
https://www.readbyqxmd.com/read/28708640/is-cleft-severity-correlated-with-intrinsic-growth-pattern-observation-from-unoperated-adult-patients-with-submucous-cleft-palate
#9
Congcong Cao, Xue Xu, Bing Shi, Qian Zheng, Jingtao Li
OBJECTIVE: This study aimed to evaluate the craniofacial morphology of unoperated adult submucous cleft palate (SMCP) patients and to explore the possible correlation between the intrinsic growth insufficiency of the maxillofacial complex and the severity of the cleft. MATERIALS AND METHODS: A total of 20 unoperated SMCP patients, 20 unoperated overt cleft palate (OCP) patients, and 32 normal controls, ages between 18 and 30, were included for cephalometric analysis...
July 13, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28688787/retrospective-analysis-of-predictors-of-proficient-power-mobility-in-young-children-with-severe-motor-impairments
#10
Shelley R H Mockler, Irene R McEwen, Maria A Jones
OBJECTIVE: The primary objective was to determine if (a) child characteristics, (b) maternal education, (c) intervention parameters, (d) type of wheelchair control mechanism, or a combination of these variables, were associated with proficient power mobility skills in children with severe motor impairments aged 14 to 30 months. The secondary purpose was to determine if performance on the Wheelchair Skills Checklist (WSC) was associated with performance on the Powered Mobility Program (PMP)...
July 5, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28687762/x-ray-snapshots-of-a-pyridoxal-enzyme-a-catalytic-mechanism-involving-concerted-1-5-hydrogen-sigmatropy-in-methionine-%C3%AE-lyase
#11
Dan Sato, Tomoo Shiba, Tsuyoshi Karaki, Wataru Yamagata, Tomoyoshi Nozaki, Takashi Nakazawa, Shigeharu Harada
Pyridoxal 5'-phosphate (PLP)-enzymes are essentially involved in amino acid and amine metabolism of a wide variety of organisms. Despite their extensive biochemical studies, there are little evidence and structural data to comprehensively elaborate the catalytic mechanism. We obtained X-ray snapshots of l-methionine γ-lyase from Entamoeba histolytica (EhMGL), a PLP-enzyme catalyzing the γ-elimination reaction of methionine. Here, we suggest a catalytic mechanism of EhMGL by using the X-ray snapshots covering all stages of this multistep catalysis reaction...
July 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28677239/microbial-community-structure-and-soil-ph-correspond-to-methane-production-in-arctic-alaska-soils
#12
Robert Wagner, Donatella Zona, Walter Oechel, David Lipson
While there is no doubt that biogenic methane production in the Arctic is an important aspect of global methane emissions, the relative roles of microbial community characteristics and soil environmental conditions in controlling Arctic methane emissions remains uncertain. Here, relevant methane-cycling microbial groups were investigated at two remote Arctic sites with respect to soil potential methane production (PMP). Percent abundances of methanogens and iron-reducing bacteria correlated with increased PMP, while methanotrophs correlated with decreased PMP...
July 5, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28672083/bleaching-earths-as-powerful-additives-for-ru-catalyzed-self-metathesis-of-non-refined-methyl-oleate-at-pilot-scale
#13
Marc Mauduit, Jessica Allard, Yann Raoul, Idriss Curbet, Fabien Tripoteau, Sophie Sambou, Guillaume Chollet, Frédéric Caijo, Christophe Crévisy, Olivier Baslé
A practical and cost-effective ruthenium-catalyzed self-metathesis of non-refined methyl oleate (85%) derived from Very High Oleic Sunflower Oils (VHOSO) was demonstrated at pilot scale using a robust and kg-scale commercially available SIPr-M71 pre-catalyst. The simple addition of 1 wt% bleaching earths (Tonsil 110FF) to a thermally pretreated oil could efficiently prevent catalyst deactivation. Remarkably, without the need for filtration, the catalytic system was able to achieve a turnover number of more than 744000 at a catalyst loading of only 1 ppm...
July 3, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28669287/prevalence-of-psychotherapy-surrounding-initiation-of-psychotropic-polypharmacy-in-the-medicaid-insured-population-1999-2010
#14
Juan M Hincapie-Castillo, Xinyue Liu, Regina Bussing, Almut G Winterstein
OBJECTIVE: This research aimed to quantify the prevalence of psychotherapy among Medicaid-insured patients within six months of initiating psychotropic medication polypharmacy (PMP). METHODS: Using the Medicaid Analytic eXtract database for 29 states from 1999 to 2010, investigators established ten two-year cohorts of pediatric and adult patients who received two or more psychotropic drugs with a 45-day overlapping days' supply. Among PMP initiators, the prevalence of psychotherapy services, identified from encounter claims via Current Procedural Terminology and Healthcare Common Procedure Coding System codes, was calculated for the six months before and the six months after initiation of PMP...
July 3, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/28669046/anticoagulant-rodenticide-exposure-and-toxicosis-in-four-species-of-birds-of-prey-in-massachusetts-usa-2012-2016-in-relation-to-use-of-rodenticides-by-pest-management-professionals
#15
Maureen Murray
Restrictions on second-generation anticoagulant rodenticides (SGARs) in the United States, which were partially implemented in 2011, prohibit the sale of SGAR products through general consumer outlets to minimize use by non-professional or non-agricultural applicators. This study analyzed liver tissue from four species of birds of prey admitted to a wildlife clinic in Massachusetts, USA, from 2012-2016 for residues of anticoagulant rodenticides (ARs). Ninety-four birds were analyzed; 16 were symptomatic for AR toxicosis, and 78 asymptomatic...
July 1, 2017: Ecotoxicology
https://www.readbyqxmd.com/read/28658075/evaluation-of-the-official-match-external-load-in-soccer-players-with-cerebral-palsy
#16
J Yanci, D Castillo, A Iturricastillo, R Reina
The aims of this study were to analyze the official match external loads (i.e. total distance [TD], distance covered at different speeds, accelerations, decelerations, player load [PL], peak metabolic power [PMP] and changes of direction [CODs]) of football players with cerebral palsy (CP), and to determine the external loads according to playing time (i.e. < 20 min, 20-40 min and > 40 min). The external load of thirty-one international football players with CP (23.0 ± 6.6 years; 69.1 ± 9.0 kg; 174...
June 22, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28627948/-renal-transplantations-in-the-centre-for-nephrology-in-szombathely-1976-2016
#17
András Dobos, Erzsébet Ruzsa, Erzsébet Molnár, Gyuláné Szakács, Imre Kulcsár
INTRODUCTION: The organized nephrological care in Szombathely commenced its activities in 1976. AIM: Follow-up of our patients who has undergone a kidney transplantation. METHOD: We used the local and national databases. RESULTS: 213 patients (7 preemptive, 206 dialyzed) had 240 renal transplantations. Only 11 of them were living organ donation. Between 69 transplantations (Tx) were carried out between 1976-1995, and 163 Tx were done in the second 20 years...
June 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28626882/quantitative-proteome-analysis-of-plasma-microparticles-for-the-characterization-of-hcv-induced-hepatic-cirrhosis-and-hepatocellular-carcinoma
#18
Raghda Saad Zaghloul Taleb, Pacint Moez, Doreen Younan, Martin Eisenacher, Matthias Tenbusch, Barbara Sitek, Thilo Bracht
PURPOSE: Hepatocellular carcinoma (HCC) is the most common primary malignant liver tumor and a leading cause of cancer-related deaths worldwide. Cirrhosis induced by hepatitis-C virus (HCV) infection is the most critical risk factor for HCC. However, the mechanism of HCV-induced carcinogenesis is not fully understood. Plasma microparticles (PMP) contribute to numerous physiological and pathological processes and contain proteins whose composition correlates to the respective pathophysiological conditions...
June 19, 2017: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/28626526/efficient-divergent-synthesis-of-new-immunostimulant-4%C3%A2-modified-%C3%AE-galactosylceramide-analogues
#19
Jonas Janssens, Tine Decruy, Koen Venken, Toshiyuki Seki, Simon Krols, Johan Van der Eycken, Moriya Tsuji, Dirk Elewaut, Serge Van Calenbergh
A synthesis strategy for the swift generation of 4″-modified α-galactosylceramide (α-GalCer) analogues is described, establishing a chemical platform to comprehensively investigate the structure-activity relationships (SAR) of this understudied glycolipid part. The strategy relies on a late-stage reductive ring-opening of a p-methoxybenzylidene (PMP) acetal to regioselectively liberate the 4″-OH position. The expediency of this methodology is demonstrated by the synthesis of a small yet diverse set of analogues, which were tested for their ability to stimulate invariant natural killer T-cells (iNKT) in vitro and in vivo...
June 8, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28605985/diagnostic-and-therapeutic-laparoscopy-in-assessment-and-management-of-patients-with-appendiceal-neoplasms
#20
Grace Hwei Ching Tan, Tushar Shamji, Akash Mehta, Kandiah Chandrakumaran, Sanjeev Dayal, Faheez Mohamed, Normal J Carr, Babtunde Rowaiye, Tom Cecil, Brendan J Moran
INTRODUCTION: Radiological imaging often underestimates the extent of low volume peritoneal disease. The benefit of laparoscopy in assessing peritoneal metastases from colorectal and gastric cancer is accepted, but is inconclusive for appendiceal malignancy. We report our experience of diagnostic (DL) and therapeutic laparoscopy (TL) in patients with appendiceal tumours to determine indications and role in assessment and management. METHODS: A retrospective review of a National Peritoneal Malignancy Centre's prospectively maintained database was performed...
June 28, 2017: International Journal of Hyperthermia
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