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fast-tract bariatric surgery

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https://www.readbyqxmd.com/read/27723911/d-lactic-acidosis-case-report-and-review-of-the%C3%A2-literature
#1
E Fabian, L Kramer, F Siebert, C Högenauer, R B Raggam, H Wenzl, G J Krejs
D-lactic acidosis is a rare complication that occurs mainly in patients with malabsorption due to a surgically altered gastrointestinal tract anatomy, namely in short bowel syndrome or after bariatric surgery. It is characterized by rapid development of neurological symptoms and severe metabolic acidosis, often with a high serum anion gap. Malabsorbed carbohydrates can be fermented by colonic microbiota capable of producing D-lactic acid. Routine clinical assessment of serum lactate covers only L-lactic acid; when clinical suspicion for D-lactic acidosis is high, special assays for D-lactic acid are called for...
October 10, 2016: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/27568470/mechanisms-of-improved-glucose-handling-after-metabolic-surgery-the-big-6
#2
REVIEW
Rebecca L Paszkiewicz, Richard N Bergman
For some time, it has been clear that elevated glucose is detrimental to the organism. A plethora of medicines have been introduced to reduce the fasting and postprandial glucose levels (including insulin, glucagon-like peptide receptor 1 [GLP-1] agonists, and sodium-glucose co-transporter 2 [SGLT2] inhibitors, among others). Although these medications are useful to reduce tissue exposure to glucose, no single compound and no combination have been able to totally normalize the blood sugar. Thus, it was astonishing when it was reported that surgery of the gastrointestinal tract could not only reduce obesity but also normalize the blood sugar...
July 2016: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/27186356/is-glp-1-a-hormone-whether-and-when
#3
REVIEW
David D'Alessio
Glucagon-like peptide-1 (GLP-1) is a product of proglucagon cleavage synthesized in L cells in the intestinal mucosa, α-cells in the pancreatic islet, and neurons in the nucleus of the solitary tract. GLP-1 is essential for normal glucose tolerance and acts through a specific GLP-1 receptor that is expressed by islet β-cells as well as other cell types. Because plasma concentrations of GLP-1 increase following meal ingestion it has been generally presumed that GLP-1 acts as a hormone, communicating information from the intestine to the endocrine pancreas through the circulation...
April 2016: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/26185747/effects-of-laparoscopic-gastric-plication-lgp-in-patients-with-type-2-diabetes-one-year-follow-up
#4
Mohammad Talebpour, Atieh Talebpour, Gilda Barzin, Reza Shariat Moharari, Mohammad Reza Khajavi
BACKGROUND: Obesity is a major risk factor for the development of type 2 diabetes mellitus. Surgery is one of the most effective treatments for morbid obesity. In a prospective cohort study, we examined the effects of Laparoscopic Gastric Plication (LGP) as a new restrictive technique on remission of type 2 diabetes mellitus. METHODS: During six years of study from June 2007 through December 2013, 62 patients who underwent bariatric surgery were recruited for our study to determine the effects of weight loss...
2015: Journal of Diabetes and Metabolic Disorders
https://www.readbyqxmd.com/read/26078577/metabolic-surgery-and-intestinal-gene-expression-digestive-tract-and-diabetes-evolution-considerations
#5
Marcos Ricardo da Silva Rodrigues, Marco Aurelio Santo, Giovani Marino Favero, Elaine Cristina Vieira, Roberto Ferreira Artoni, Viviane Nogaroto, Egberto Gaspar de Moura, Patricia Lisboa, Fabio Quirillo Milleo
AIM: To investigate the effects of bariatric surgery on metabolic parameters, incretin hormone secretion, and duodenal and ileal mucosal gene expression. METHODS: Nine patients with type 2 diabetes mellitus (T2DM), chronic serum hyperglycemia for more than 2 years, and a body mass index (BMI) of 30-35 kg/m(2) underwent metabolic surgery sleeve gastrectomy with transit bipartition between May 2011 and December 2011. Blood samples were collected pre and 3, 6 and 12 mo postsurgery...
June 14, 2015: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/23230996/glucagon-like-peptide-1-glp-1-dynamics-following-bariatric-surgery-a-signpost-to-a-new-frontier
#6
REVIEW
K J Neff, D O'Shea, C W le Roux
Glucagon like peptide-1 (GLP-1) is one of the gastrointestinal peptides implicated in glycaemic homeostasis. In non-obese individuals with normal glucose tolerance GLP-1 is secreted in response to nutrient intake. However, this GLP- 1 response is generally accepted to be significantly diminished in those with diabetes, obesity or both. Given that GLP-1 is secreted from enteroendocrine L cells in the intestine, it is not surprising that manipulation of the gastro- intestinal tract has been shown to alter GLP-1 secretion; particularly when this intestinal manipulation is designed to aid weight reduction...
March 1, 2013: Current Diabetes Reviews
https://www.readbyqxmd.com/read/23074527/bariatric-surgery-for-people-with-diabetes-and-morbid-obesity-an-evidence-based-analysis
#7
(no author information available yet)
UNLABELLED: In June 2008, the Medical Advisory Secretariat began work on the Diabetes Strategy Evidence Project, an evidence-based review of the literature surrounding strategies for successful management and treatment of diabetes. This project came about when the Health System Strategy Division at the Ministry of Health and Long-Term Care subsequently asked the secretariat to provide an evidentiary platform for the Ministry's newly released Diabetes Strategy.After an initial review of the strategy and consultation with experts, the secretariat identified five key areas in which evidence was needed...
2009: Ontario Health Technology Assessment Series
https://www.readbyqxmd.com/read/22923664/alterations-in-gastrointestinal-endocrine-and-metabolic-processes-after-bariatric-roux-en-y-gastric-bypass-surgery
#8
Christian-Heinz Anderwald, Andrea Tura, Miriam Promintzer-Schifferl, Gerhard Prager, Marietta Stadler, Bernhard Ludvik, Harald Esterbauer, Martin Georg Bischof, Anton Luger, Giovanni Pacini, Michael Krebs
OBJECTIVE: Obesity leads to severe long-term complications and reduced life expectancy. Roux-en-Y gastric bypass (RYGB) surgery induces excessive and continuous weight loss in (morbid) obesity, although it causes several abnormal anatomical and physiological conditions. RESEARCH DESIGN AND METHODS: To distinctively unveil effects of RYGB surgery on β-cell function and glucose turnover in skeletal muscle, liver, and gut, nondiabetic, morbidly obese patients were studied before (pre-OP, five female/one male, BMI: 49 ± 3 kg/m(2), 43 ± 2 years of age) and 7 ± 1 months after (post-OP, BMI: 37 ± 3 kg/m(2)) RYGB surgery, compared with matching obese (CON(ob), five female/one male, BMI: 34 ± 1 kg/m(2), 48 ± 3 years of age) and lean controls (CON(lean), five female/one male, BMI: 22 ± 0 kg/m(2), 42 ± 2 years of age)...
December 2012: Diabetes Care
https://www.readbyqxmd.com/read/22173445/-influence-of-bariatric-surgery-on-remission-of-type-2-diabetes
#9
Paweł Nalepa, Aleksandra Piechnik, Anna Kiersztan
The plague of obesity afflicts an increasing group of people. Moreover type 2 diabetes, which is the most serious illness accompanying excessive weight, is becoming more and more common. Traditional methods of obesity treatment, such as diet and physical exercise, fail. This applies especially to people with class III obesity. The only successful way of treating obesity in their case is bariatric surgery. There are three types of bariatric surgery: restrictive procedures (reducing stomach volume), malabsorptive procedures, and mixed procedures, which combine both methods...
2011: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/21381002/antidiabetic-effects-of-duodenojejunal-bypass-in-an-experimental-model-of-diabetes-induced-by-a-high-fat-diet
#10
M Woods, Z Lan, J Li, M B Wheeler, H Wang, R Wang
BACKGROUND: Obese patients with type II diabetes who undergo bariatric surgery revert to normal blood glucose and insulin levels, and develop a dramatic increase in insulin sensitivity. However, the mechanisms involved are unknown. This study characterized pancreatic islet and duodenojejunal enteroendocrine cells in normal mice and those with diabetes induced by a high-fat diet (HFD) following duodenojejunal bypass (DJB). METHODS: C57BL/6J mice, fed for 8 weeks either a normal diet (n = 10) or a HFD (n = 10) resulting in a hyperglycaemic state, underwent DJB (connection of the distal end of the jejunum to the distal stomach and direction of biliopancreatic secretions to the distal jejunum)...
May 2011: British Journal of Surgery
https://www.readbyqxmd.com/read/21256091/preliminary-comparison-of-sertraline-levels-in-postbariatric-surgery-patients-versus-matched-nonsurgical-cohort
#11
COMPARATIVE STUDY
James L Roerig, Kristine Steffen, Cheryl Zimmerman, James E Mitchell, Ross D Crosby, Li Cao
BACKGROUND: Roux-en-Y gastric bypass (RYGB) is the most frequent bariatric procedure performed in the United States, with thousands performed. Because of the changes to the gastrointestinal tract, the potential exists for clinically significant alterations in the absorption/bioavailability of ingested medications. The purpose of the present pilot trial was to determine to what extent RYGB alters the area under the plasma concentration/time curve (AUC(0-10.5)) of the antidepressant, sertraline at a community research center...
January 2012: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/20431947/small-intestinal-clustered-contractions-and-bacterial-overgrowth-a-frequent-finding-in-obese-patients
#12
Ana María Madrid, Jaime Poniachik, Rodrigo Quera, Carlos Defilippi
BACKGROUND: Small intestinal bacterial overgrowth (SIBO) has been observed in several disorders of the gastrointestinal tract. Studies have shown abnormalities of motor function in obese patients, and there is indirect evidence suggesting that SIBO is present in them. AIMS: To study small intestinal motility and the prevalence of SIBO in obese patients and to determine whether there was any relationship between both parameters. METHODS: Thirty-nine patients scheduled for bariatric surgery were subjected to hydrogen breath test with lactulose and to a stationary small intestinal motility study with perfused catheters...
January 2011: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/18080721/enterohormonal-changes-after-digestive-adaptation-five-year-results-of-a-surgical-proposal-to-treat-obesity-and-associated-diseases
#13
Sérgio Santoro, Fábio Quirilo Milleo, Carlos Eduardo Malzoni, Sidney Klajner, Pedro C M Borges, Marco Aurélio Santo, Fábio Guilherme Campos, Roberto Ferreira Artoni
BACKGROUND: Recent physiological knowledge allows the design of bariatric procedures that aim at neuroendocrine changes instead of at restriction and malabsorption. Digestive adaptation is a surgical technique for obesity based in this rationale. METHODS: The technique includes a sleeve gastrectomy, an omentectomy and a jejunectomy that leaves initial jejunum and small bowel totaling at least 3 m (still within normal variation of adult human bowel length). Fasting ghrelin and resistin and fasting and postprandial GLP-1 and PYY were measured pre- and postoperatively...
January 2008: Obesity Surgery
https://www.readbyqxmd.com/read/16804072/mechanisms-of-recovery-from-type-2-diabetes-after-malabsorptive-bariatric-surgery
#14
Caterina Guidone, Melania Manco, Elena Valera-Mora, Amerigo Iaconelli, Donatella Gniuli, Andrea Mari, Giuseppe Nanni, Marco Castagneto, Menotti Calvani, Geltrude Mingrone
Currently, there are no data in the literature regarding the pathophysiological mechanisms involved in the rapid resolution of type 2 diabetes after bariatric surgery, which was reported as an additional benefit of the surgical treatment for morbid obesity. With this question in mind, insulin sensitivity, using euglycemic-hyperinsulinemic clamp, and insulin secretion, by the C-peptide deconvolution method after an oral glucose load, together with the circulating levels of intestinal incretins and adipocytokines, have been studied in 10 diabetic morbidly obese subjects before and shortly after biliopancreatic diversion (BPD) to avoid the weight loss interference...
July 2006: Diabetes
https://www.readbyqxmd.com/read/16224039/effect-of-parenteral-nutrition-on-nutrition-status-after-bariatric-surgery-for-morbid-obesity
#15
COMPARATIVE STUDY
M A Martínez Olmos, M J Martínez Vázquez, M J Morales Gorría, P Parada González, I Otero Martínez, I Maruri Chimeno, E Pena González, M T Inaraja Bobo, J E Casal Núñez
BACKGROUND: To evaluate the influence of nutrition support (parenteral nutrition [PN] vs no parenteral nutrition [nPN]) on nutrition outcome, complications, and hospital stay after bariatric surgery (BS). METHODS: Sixty-seven consecutive BS patients (17 gastric bypass and 50 biliopancreatic diversion). The first 38 received PN and the next 29 did not (nPN) during the fasting postoperative (PO) period. In both groups, after fasting, a progressive oral diet was introduced...
November 2005: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/15561918/beta-cell-function-in-obesity-effects-of-weight-loss
#16
REVIEW
Ele Ferrannini, Stefania Camastra, Amalia Gastaldelli, Anna Maria Sironi, Andrea Natali, Elza Muscelli, Geltrude Mingrone, Andrea Mari
In nondiabetic subjects, obesity is associated with a modest expansion of beta-cell mass, possibly amounting-according to the best available estimates-to 10-30% for each 10 kg of weight excess. Whether age of onset and duration of obesity, recent changes in body weight, and body fat distribution have any effect on beta-cell mass in humans is unknown. Both fasting insulin secretion and the total insulin response to oral glucose have the following characteristics: 1) they increase with BMI in an approximately linear fashion, 2) both fat-free and fat mass are significant positive correlates, and 3) BMI exerts a positive effect separate from that of insulin resistance (i...
December 2004: Diabetes
https://www.readbyqxmd.com/read/12082896/does-reduction-in-gastric-acid-secretion-in-bariatric-surgery-increase-diet-induced-thermogenesis
#17
John Melissas, Emmanuel Kampitakis, George Schoretsanitis, John Mouzas, Elias Kouroumalis, Demetrios D Tsiftsis
BACKGROUND: Patients who have undergone gastrectomy for benign ulcer do not develop obesity. Furthermore, morbidly obese patients who undergo biliopancreatic diversion (BPD), Roux-en-Y gastric bypass (RYGBP) and vertical banded gastroplasty (VBG) plus truncal vagotomy, may lose more weight compared with patients who undergo VBG alone. A common characteristic of the above is the reduction of gastric hydrochloric acid secretion. We investigated whether reduction in gastric acid increases dietary-induced thermogenesis because of maldigestion of foods, and this may account for the greater weight loss in the above situations...
June 2002: Obesity Surgery
https://www.readbyqxmd.com/read/11975219/does-reduction-in-gastric-acid-secretion-in-bariatric-surgery-increase-diet-induced-thermogenesis
#18
John Melissas, Emmanuel Kampitakis, George Schoretsanitis, John Mouzas, Elias Kouroumalis, Demetrios D Tsiftsis
BACKGROUND: Patients who have undergone gastrectomy for benign ulcer do not develop obesity. Furthermore, morbidly obese patients who undergo biliopancreatic diversion (BPD), Roux-en-Y gastric bypass (RYGBP) and vertical banded gastroplasty (VBG) plus truncal vagotomy, may lose more weight compared with patients who undergo VBG alone. A common characteristic of the above is the reduction of gastric hydrochloric acid secretion. We investigated whether reduction in gastric acid increases dietary-induced thermogenesis because of maldigestion of foods, and this may account for the greater weight loss in the above situations...
April 2002: Obesity Surgery
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