keyword
https://read.qxmd.com/read/38471459/temporal-trends-in-severe-brain-injury-and-associated-outcomes-in-very-preterm-infants
#21
JOURNAL ARTICLE
Abdul Razak, Emily Johnston, Alice Stewart, Marissa A T Clark, Penelope Stevens, Margaret Charlton, Flora Wong, C McDonald, Rod W Hunt, Suzanne Miller, Atul Malhotra
INTRODUCTION: Severe brain injury (SBI), including severe intraventricular haemorrhage (sIVH) and cystic periventricular leukomalacia, poses significant challenges for preterm infants, yet recent data and trends are limited. METHODS: Analyses were conducted using the Australian and New Zealand Neonatal Network data on preterm infants born <32 weeks' gestation admitted at Monash Children's Hospital, Australia, from January 2014 to April 2021. The occurrence and trends of SBI and sIVH among preterm infants, along with the rates and trends of death and neurodevelopmental impairment (NDI) in SBI infants were assessed...
March 12, 2024: Neonatology
https://read.qxmd.com/read/38467043/surviving-against-the-odds-exploring-the-clinical-and-radiological-features-of-iniencephaly-compatible-with-life-illustrative-case
#22
JOURNAL ARTICLE
Hassan Kadri, Mazen Dughly, Mohamad Shehadeh Agha, Raed Abouharb, Rostom Mackieh, Sameer Bakleh, Thea Kadri
BACKGROUND: Iniencephaly is a rare neural tube defect (NTD) characterized by deformities in the occiput and inion, along with rachischisis in the cervical and thoracic spine, resulting in the head appearing in retroflexion. OBSERVATIONS: This report details the case of a female newborn who underwent surgery for an encephalocele. She survived up to 6 months, exhibiting good overall health, although she displayed physical abnormalities, including facial deformity, a short neck, and minor spasms in all limbs...
March 11, 2024: J Neurosurg Case Lessons
https://read.qxmd.com/read/38466410/pregnancy-and-neonatal-outcomes-in-25-pregnant-women-diagnosed-with-new-onset-acute-myeloid-leukemia-during-pregnancy
#23
JOURNAL ARTICLE
Jing Ding, YiHan Xiao, Jie Fu, Guoli Liu, Shanyamei Huang, Xiaodong Mo
PURPOSE: The aim was to analyze the pregnancy and neonatal outcomes of pregnant women with new- onset acute myeloid leukemia (AML) diagnosed during pregnancy. METHODS: In this retrospective study 25 pregnant women who were diagnosed with new-onset AML during pregnancy from January 2010 to January 2021 were enrolled. RESULTS: A total of 4, 13 and 8 pregnant women with new-onset AML were diagnosed during the first, second, and third trimesters, respectively...
March 11, 2024: Archives of Gynecology and Obstetrics
https://read.qxmd.com/read/38461794/disruption-of-gonocyte-development-following-neonatal-exposure-to-di-2-ethylhexyl-phthalate
#24
JOURNAL ARTICLE
Estefanía Reyes-Cruz, Julio César Rojas-Castañeda, Daniel Adrian Landero-Huerta, Norma Hernández-Jardón, Rafael Reynoso-Robles, María de Lourdes Juárez-Mosqueda, Alfredo Medrano, Rosa María Vigueras-Villaseñor
Pre- and/or post-natal administrations of di(2-ethylhexyl) phthalate (DEHP) in experimental animals cause alterations in the spermatogenesis. However, the mechanism by which DEHP affects fertility is unknown and could be through alterations in the survival and differentiation of the gonocytes. The aim of the present study was to evaluate the effect of a single administration of DEHP in newborn mice on gonocytic proliferation, differentiation and survival and its long-term effects on seminiferous epithelium and sperm quality...
March 9, 2024: Reproductive Biology
https://read.qxmd.com/read/38459147/neurosurgical-intervention-for-the-meckel-gruber-syndrome-a-systematic-review
#25
REVIEW
Jefferson Heber Marques Fontes Junior, Silvio Porto Junior, Hugo Nunes Pustilnik, Leonardo de Almeida Leão, Matheus Gomes da Silva da Paz, Taiane Brito Araujo, Fernanda Oliveira Gonçalves de Deus, Tancredo Alcântara, Jules Carlos Dourado, Leonardo Miranda de Avellar
INTRODUCTION: Meckel-Gruber Syndrome (MKS) is an autosomal recessive genetic disorder, notable for its triad of occipital encephalocele, polycystic renal dysplasia, and postaxial polydactyly. Identified by Johann Friederich Meckel in 1822, MKS is categorized as a ciliopathy due to gene mutations. Diagnosis is confirmed by the presence of at least two key features. The condition is incompatible with life, leading to death in the womb or shortly after birth. Recent studies have largely focused on the genetic aspects of MKS, with limited information regarding the impact of neurosurgical approaches, particularly in treating encephaloceles...
March 9, 2024: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://read.qxmd.com/read/38454369/health-facility-assessment-of-small-and-sick-newborn-care-in-low-and-middle-income-countries-systematic-tool-development-and-operationalisation-with-nest360-and-unicef
#26
JOURNAL ARTICLE
Rebecca E Penzias, Christine Bohne, Samuel K Ngwala, Evelyn Zimba, Norman Lufesi, Ekran Rashid, Edith Gicheha, Opeyemi Odedere, Olabisi Dosunmu, Robert Tillya, Josephine Shabani, James H Cross, Sara Liaghati-Mobarhan, Msandeni Chiume, George Banda, Alfred Chalira, John Wainaina, David Gathara, Grace Irimu, Steve Adudans, Femi James, Olukemi Tongo, Veronica Chinyere Ezeaka, Georgina Msemo, Nahya Salim, Louise T Day, Timothy Powell-Jackson, Jaya Chandna, Maureen Majamanda, Elizabeth M Molyneux, Maria Oden, Rebecca Richards-Kortum, Eric O Ohuma, Chris Paton, Tedbabe Hailegabriel, Gagan Gupta, Joy E Lawn
BACKGROUND: Each year an estimated 2.3 million newborns die in the first 28 days of life. Most of these deaths are preventable, and high-quality neonatal care is fundamental for surviving and thriving. Service readiness is used to assess the capacity of hospitals to provide care, but current health facility assessment (HFA) tools do not fully evaluate inpatient small and sick newborn care (SSNC). METHODS: Health systems ingredients for SSNC were identified from international guidelines, notably World Health Organization (WHO), and other standards for SSNC...
March 7, 2024: BMC Pediatrics
https://read.qxmd.com/read/38453076/living-in-a-dynamic-environment-the-effects-of-multi-ways-temperature-variation-on-embryo-and-newborn-juveniles-of-a-shallow-water-octopus-amphioctopus-fangsiao
#27
JOURNAL ARTICLE
Jian Zheng, Shuwen Li, Xiaodong Zheng
Shallow waters are characterized by fluctuating environmental conditions, modulating marine life cycles and biological phenomena. Multiple variations in water temperature could affect eggs and embryos during spawning events of many marine invertebrate species, yet most of the findings on embryonic development in invertebrates come from experiments based on the constant temperature. In this study, to examine the effects of temperature variation on octopus embryos, Amphioctopus fangsiao, a common shallow-water octopus along the coast of China, was exposed to the constant temperature (18 °C, in situ temperature of the seawater in Lianyungang), ramping temperatures (from 18 to 24 °C), diel oscillating temperatures (18 °C and 20 °C for 12 h each day), and acute increasing temperatures (the temperature increased sharply from 18 °C to 24 °C at embryonic development stage XIX) for 47 days (from embryogenesis to settlement)...
March 5, 2024: Science of the Total Environment
https://read.qxmd.com/read/38442954/outcomes-following-the-adoption-of-standard-parenteral-nutrition-in-preterm-infants-a-whole-population-non-concurrent-control-study
#28
JOURNAL ARTICLE
Jessica Burgess-Shannon, Mohammad Chehrazi, Julia Lanoue, Neena Modi, Sabita N Uthaya
OBJECTIVE: To evaluate the impact of a quality improvement project of the adoption of standard parenteral nutrition (SPN) in preterm infants. DESIGN: Retrospective, multicentre, whole-population, non-concurrent control study using data from the UK National Neonatal Research Database between 1 January 2014 and 31 December 2020. SETTING: Neonatal units in London UK organised by geographical network. PATIENTS: Preterm infants <31 weeks' gestation...
March 4, 2024: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://read.qxmd.com/read/38441196/role-of-bacteria-and-microbial-metabolites-in-immune-modulation-during-early-life
#29
JOURNAL ARTICLE
Tine Simensen Oldereid, Xiaojun Jiang, Kathrine Sivertsen Nordhus, Andrea Ponzetta, Jørgen Vildershøj Bjørnholt, Niklas K Björkström, Espen Melum, Henrik Rasmussen
Host-microbiome interplay from birth is essential for immune imprinting and tuning. Live gut microbes and microbial-derived metabolites regulate the development and modulation of the immune system, but whether microbial metabolites solely are sufficient to induce immune maturation remains unclear. Sterile faecal filtrates (FFT) were generated from murine gut contents. Newborn germ-free (GF) mice were treated twice daily with FFT (GF-FFT) or saline (GF-NaCl) from post-natal day 5 until 4 weeks of age...
February 2024: Scandinavian Journal of Immunology
https://read.qxmd.com/read/38437802/association-between-intermittent-hypoxemia-and-nicu-length-of-stay-in-preterm-infants
#30
JOURNAL ARTICLE
Anna Maria Hibbs, Zhengyi Chen, Nori M Minich, Richard J Martin, Thomas M Raffay, Peter M MacFarlane, Juliann M Di Fiore
INTRODUCTION: Length of hospitalization varies widely in preterm infants and can be affected by multiple maternal and neonatal factors including respiratory instability. Therefore, we aimed to determine the association between postnatal intermittent hypoxemia (IH) and prolonged hospitalization. METHODS: This prospective single-center cohort study followed infants born at &lt;31 weeks of gestational age through 2 years corrected age with detailed oxygen saturation data captured from days 7 to 30 of age...
March 4, 2024: Neonatology
https://read.qxmd.com/read/38436999/biochemical-properties-of-sheep-colostrum-and-its-potential-benefits-for-lamb-survival-a-review
#31
REVIEW
Umar Farooq, Sohail Ahmed, Guiqiong Liu, Xunping Jiang, Huiguo Yang, Jianping Ding, Mehboob Ali
Colostrum is the initial secretion of the mammary glands following parturition, which offers main food, protection, and biological active substances for the new born. The most threatening episode of neonate's life is the initial two weeks after birth. This period is associated with high neonatal mortality and morbidity. These worthwhile losses lead to a poor prolificacy rate, low profitability, and ultimately poor performance in animal production. Hence, both diseases and mortality cause valuable losses in terms of production and economic losses...
March 4, 2024: Animal Biotechnology
https://read.qxmd.com/read/38435156/presurgical-use-of-hypoxic-mixture-for-systemic-perfusion-improvement-in-neonates-with-complex-congenital-heart-disease-a-systematic-review-and-meta-analysis
#32
REVIEW
Delia E Theurel Martín, Jorge L Alvarado Socarras, Edgar F Manrique Hernández, Mónica A Sandoval, Alvaro J Coronado Munoz
Oxygen therapy is essential for the survival of preterm babies and critically ill newborns; however, it has the potential to cause harm through hypoxemia or hyperoxemia. Newborns with complex congenital heart diseases (CHD) suffer from oxygen fluctuations due to the disease and its treatments, altering pre and postnatal development. The objective of this study is to evaluate the evidence for using a hypoxic mixture to decrease pulmonary over-circulation and improve systemic perfusion before surgical interventions in newborns with complex CHD that course with pulmonary over-circulation and systemic hypoperfusion...
February 2024: Curēus
https://read.qxmd.com/read/38432296/young-infant-mortality-associated-with-preterm-and-small-for-gestational-age-births-in-rural-bangladesh-a-prospective-cohort-study
#33
JOURNAL ARTICLE
Jennifer A Applegate, Md Shafiqul Islam, Rasheda Khanam, Arunangshu Dutta Roy, Nabidul Haque Chowdhury, Salahuddin Ahmed, Dipak K Mitra, Arif Mahmud, Mohammad Shahidul Islam, Samir K Saha, Abdullah H Baqui
OBJECTIVE: To assess the relative risk of mortality in preterm and small-for-gestational-age (SGA) infants during the first and second months of life in rural Bangladesh. STUDY DESIGN: We analyzed data from a cohort of pregnant women and their babies in Sylhet, Bangladesh, assembled between 2011 and 2014. Community health workers visited enrolled babies up to 10 times from birth to age 59 days. Survival status was recorded at each visit. Gestational age was estimated from mother's reported last menstrual period...
March 1, 2024: Journal of Pediatrics
https://read.qxmd.com/read/38429824/ultrasound-findings-and-specific-intrinsic-blood-volume-expansion-therapy-for-neonatal-capillary-leak-syndrome-report-from-a-multicenter-prospective-self-control-study
#34
JOURNAL ARTICLE
Jing Liu, Yue-Qiao Gao, Wei Fu
OBJECTIVE: Capillary leak syndrome (CLS) is characterized by severe systemic edema without specific treatment, resulting in a high mortality rate. This study investigated whether there is organ edema in neonatal CLS patients and specific treatment strategies to improve patient prognosis. METHODS: Thirty-seven newborns diagnosed with CLS were included in this study. (1) Routine point-of-care ultrasound (POCUS) was used to identify whether the patients had visceral edema or fluid collection...
March 1, 2024: European Journal of Medical Research
https://read.qxmd.com/read/38426063/genomic-and-ecological-approaches-to-identify-the-bifidobacterium-breve-prototype-of-the-healthy-human-gut-microbiota
#35
JOURNAL ARTICLE
Chiara Argentini, Gabriele Andrea Lugli, Chiara Tarracchini, Federico Fontana, Leonardo Mancabelli, Alice Viappiani, Rosaria Anzalone, Leonora Angelini, Giulia Alessandri, Giulia Longhi, Massimiliano G Bianchi, Giuseppe Taurino, Ovidio Bussolati, Christian Milani, Douwe van Sinderen, Francesca Turroni, Marco Ventura
Members of the genus Bifidobacterium are among the first microorganisms colonizing the human gut. Among these species, strains of Bifidobacterium breve are known to be commonly transmitted from mother to her newborn, while this species has also been linked with activities supporting human wellbeing. In the current study, an in silico approach, guided by ecology- and phylogenome-based analyses, was employed to identify a representative strain of B. breve to be exploited as a novel health-promoting candidate...
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38424485/searching-for-homozygous-haplotype-deficiency-in-manech-t%C3%A3%C2%AAte-rousse-dairy-sheep-revealed-a-nonsense-variant-in-the-mmut-gene-affecting-newborn-lamb-viability
#36
JOURNAL ARTICLE
Maxime Ben Braiek, Carole Moreno-Romieux, Céline André, Jean-Michel Astruc, Philippe Bardou, Arnaud Bordes, Frédéric Debat, Francis Fidelle, Itsasne Granado-Tajada, Chris Hozé, Florence Plisson-Petit, François Rivemale, Julien Sarry, Némuel Tadi, Florent Woloszyn, Stéphane Fabre
BACKGROUND: Recessive deleterious variants are known to segregate in livestock populations, as in humans, and some may be lethal in the homozygous state. RESULTS: We used phased 50 k single nucleotide polymorphism (SNP) genotypes and pedigree data to scan the genome of 6845 Manech Tête Rousse dairy sheep to search for deficiency in homozygous haplotypes (DHH). Five Manech Tête Rousse deficient homozygous haplotypes (MTRDHH1 to 5) were identified, with a homozygous deficiency ranging from 84 to 100%...
February 29, 2024: Genetics, Selection, Evolution: GSE
https://read.qxmd.com/read/38423547/impact-of-topical-applications-of-sunflower-seed-oil-on-neonatal-mortality-and-morbidity-in-southern-nepal-a-community-based-cluster-randomised-trial
#37
JOURNAL ARTICLE
Joanne Katz, Subarna K Khatry, Laxman Shrestha, Aimee Summers, Marty O Visscher, Jeevan B Sherchand, James M Tielsch, Seema Subedi, Steven C LeClerq, Luke C Mullany
INTRODUCTION: Hospital-based studies have demonstrated topical applications of sunflower seed oil (SSO) to skin of preterm infants can reduce nosocomial infections and improve survival. In South Asia, replacing traditional mustard with SSO might have similar benefits. METHODS: 340 communities in Sarlahi, Nepal were randomised to use mustard oil (MO) or SSO for community practice of daily newborn massage. Women were provided oil in late pregnancy and the first month post partum, and visited daily through the first week of life to encourage massage practice...
February 29, 2024: BMJ Global Health
https://read.qxmd.com/read/38422331/prevalence-and-predictors-of-breastfeeding-in-the-mina-brazil-cohort
#38
JOURNAL ARTICLE
Paola S Mosquera, Bárbara H Lourenço, Alicia Matijasevich, Marcia C Castro, Marly A Cardoso
OBJECTIVE: To describe the prevalence and factors associated with exclusive (EBF) and continued breastfeeding (BF) practices among Amazonian children. METHODS: Data from 1,143 mother-child pairs recorded on the Maternal and Child Health and Nutrition in Acre (MINA-Brazil) birth cohort were used. Information on EBF and BF was collected after childbirth (July 2015-June 2016) and during the follow-up visits at 1 and 6 months postpartum, 1, 2, and 5 years of age. For longitudinal analysis, the outcomes were EBF and BF duration...
2024: Revista de Saúde Pública
https://read.qxmd.com/read/38421237/the-outcome-of-reduced-and-non-reduced-triplet-pregnancies-managed-in-a-tertiary-hospital-during-a-15-year-period%C3%A2-a-retrospective-cohort-study
#39
JOURNAL ARTICLE
Riina Maria Jernman, Annu-Riikka Susanna Rissanen, Vedran Stefanovic
OBJECTIVES: Triplet pregnancies involve several complications, the most important being prematurity as virtually all triplets are born preterm. We conducted this study to compare the outcomes of reduced vs. non-reduced triplet pregnancies managed in the largest tertiary hospital in Finland. METHODS: This was a retrospective cohort study in the Helsinki University Hospital during 2006-2020. Data on the pregnancies, parturients and newborns were collected from patient records...
March 1, 2024: Journal of Perinatal Medicine
https://read.qxmd.com/read/38420959/-gastroschisis-and-omphalocele-incidence-and-outcome
#40
JOURNAL ARTICLE
Kristin Fjola Reynisdottir, Hulda Hjartardottir, Thrainn Rosmundsson, Thordur Thorkelsson
INTRODUCTION: Gastroschisis and omphalocele are the most common congenital abdominal wall defects. The main purpose of this study was to investigate the incidence, other associated anomalies and the course of these diseases in Iceland. MATERIAL AND METHODS: The study was retrospective. The population was all newborns who were admitted to the NICU of Children's Hospital Iceland due to gastroschisis or omphalocele in 1991-2020. Furthermore, all fetuses diagnosed prenatally or post mortem where the pregnancy ended in spontaneous or induced abortion, were included...
2024: Læknablađiđ
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