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Newborn survival

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https://www.readbyqxmd.com/read/29468832/becoming-breastfeeding-friendly-index-development-and-application-for-scaling-up-breastfeeding-programmes-globally
#1
Rafael Pérez-Escamilla, Amber J Hromi-Fiedler, Muriel Bauermann Gubert, Katie Doucet, Sara Meyers, Gabriela Dos Santos Buccini
Global efforts to further improve exclusive breastfeeding rates have not been successful, in part because effective scaling-up frameworks and roadmaps have not been developed. The Becoming Breastfeeding Friendly (BBF) toolbox includes an evidence-based index, the BBF Index (BBFI), to guide the development and tracking of large scale, well-coordinated, multisector national breastfeeding promotion programmes. This paper describes the development of the BBFI, which is grounded in the Breastfeeding Gear Model complex adaptive systems framework...
February 22, 2018: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/29467521/rapid-resolution-of-hyperammonemia-in-neonates-using-extracorporeal-membrane-oxygenation-as-a-platform-to-drive-hemodialysis
#2
Jamie R Robinson, Patricia C Conroy, Daphne Hardison, Rizwan Hamid, Peter H Grubb, John B Pietsch, Harold N Lovvorn
OBJECTIVE: We aimed to clarify the impact of extracorporeal membrane oxygenation (ECMO) as a platform to drive hemodialysis (HD) for ammonia clearance on outcomes of neonates with severe hyperammonemia. STUDY DESIGN: All neonates treated for hyperammonemia at a single children's hospital between 1992 and 2016 were identified. Patient characteristics and outcomes were compared between those receiving medical management or ECMO/HD. RESULT: Twenty-five neonates were treated for hyperammonemia, of which 13 (52%) received ECMO/HD...
February 21, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29467314/a-prominent-role-of-the-human-cytomegalovirus-ul8-glycoprotein-restraining-pro-inflammatory-cytokine-production-by-myeloid-cells-at-late-times-during-infection
#3
Natàlia Pérez-Carmona, Pablo Martínez-Vicente, Domènec Farré, Ildar Gabaev, Martin Messerle, Pablo Engel, Ana Angulo
Human cytomegalovirus (HCMV) persistence in infected individuals relies on a plethora of mechanisms to efficiently reduce host immune responses. To that end, HCMV commits a variety of gene products, some of which have not been identified yet. Here we characterized the UL8 gene, which consists of two exons, sharing the first with the HCMV RL11 family member UL7 UL8 is a transmembrane protein with an N-terminal immunoglobulin (Ig)-like domain in common with UL7 but with an extended stalk and a distinctive cytoplasmic tail...
February 21, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29459604/immediate-outcome-of-preterm-neonates-with-respiratory-distress-syndrome-required-mechanical-ventilation
#4
M A Mannan, M A Hossain, J Nasim, Y Sabina, F Navila, D Subir
Since its inception, the neonatal mechanical ventilator has been considered an essential tool for managing preterm neonates with Respiratory Distress Syndrome (RDS) and is still regarded as an integral component in the neonatal respiratory care continuum. Mechanical ventilation of newborn has been practiced for several years with several advances made in the way. This clinical intervention study was done to analyze immediate outcome of preterm neonates with RDS required mechanical ventilation and conducted on preterm neonates with RDS required mechanical ventilation from July 2014 to June 2015...
January 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29458446/early-development-and-reproductive-lifespan-of-rabbit-females-implications-of-growth-rate-rearing-diet-and-body-condition-at-first-mating
#5
E Martínez-Paredes, L Ródenas, J J Pascual, D Savietto
Factors influencing early development such as birth weight, nest competition, and the diet received during rearing have been proposed as elements conditioning the future reproductive performance of European rabbit (Oryctolagus cuniculus) females. To evaluate their effects, we followed the life of 1513 females from birth to time of death, culling or censoring (animals alive at a fixed date). Between 0 and 63 days of age 353 females died. From the remaining 1160 females, 864 were chosen based on their birth weight to be transferred from the selection to the production farm...
February 20, 2018: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29458193/attenuation-of-neuro-inflammation-improves-survival-and-neurodegeneration-in-a-mouse-model-of-severe-neonatal-hyperbilirubinemia
#6
Simone Vodret, Giulia Bortolussi, Alessandra Iaconcig, Elena Martinelli, Claudio Tiribelli, Andrés F Muro
All pre-term newborns and a high proportion of term newborns develop neonatal jaundice. Neonatal jaundice is usually a benign condition and self-resolves within few days after birth. However, a combination of unfavorable complications may lead to acute hyperbilirubinemia. Excessive hyperbilirubinemia may be toxic for the developing nervous system leading to severe neurological damage and death by kernicterus. Survivors show irreversible neurological deficits such as motor, sensitive and cognitive abnormalities...
February 16, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29456516/the-socio-communicative-development-of-preterm-infants-is-resistant-to-the-negative-effects-of-parity-on-maternal-responsiveness
#7
Ivete F R Caldas, Marilice F Garotti, Victor K M Shiramizu, Antonio Pereira
Humans are born completely dependent on adult care for survival. To get the necessary support, newborns rely on socio-communicative abilities which have both innate and learned components. Maternal responsiveness (MR), as a critical aspect of mother-infant interaction, is a robust predictor of the acquisition of socio-communicative abilities. However, maternal responsiveness (MR) is influenced by parity, since mothers rely on a limited capacity of cognitive control for efficient attachment with their offspring...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29453205/co-deficiency-of-lysosomal-mucolipins-3-and-1-in-cochlear-hair-cells-diminishes-outer-hair-cell-longevity-and-accelerates-age-related-hearing-loss
#8
Teerawat Wiwatpanit, Natalie N Remis, Aisha Ahmad, Yingjie Zhou, John C Clancy, Mary Ann Cheatham, Jaime García-Añoveros
Acquired hearing loss is the predominant neurodegenerative condition associated with aging in humans. Although mutations on several genes are known to cause congenital deafness in newborns, few genes have been implicated in age-related hearing loss (ARHL), perhaps because its cause is likely polygenic. Here, we generated mice lacking lysosomal calcium channel mucolipins 3 and 1 and discovered that both male and female mice suffered a polygenic form of hearing loss. While mucolipin 1 is ubiquitously expressed in all cells, mucolipin 3 is expressed in a small subset of cochlear cells -hair cells (HCs) and marginal cells of the stria vascularis- and very few other cell types...
February 16, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29448836/aav8-gene-therapy-rescues-the-newborn-phenotype-of-a-mouse-model-of-crigler-najjar
#9
Jenny A Greig, Jayme M L Nordin, Christine Draper, Peter Bell, James M Wilson
Adeno-associated viral (AAV) vectors can target the liver, making them an attractive platform for gene therapy approaches that require the correction of hepatocytes. Crigler-Najjar syndrome is an autosomal recessive disorder of bilirubin metabolism that occurs when the liver's uridine diphosphate glucuronosyl transferase 1A1 (UGT1A1) enzyme activity is partially or completely absent. This syndrome is characterized by elevated bilirubin levels in the blood. We developed an AAV8 vector expressing a codon-optimized human version of UGT1A1 from a liver-specific promoter...
February 16, 2018: Human Gene Therapy
https://www.readbyqxmd.com/read/29447823/exit-ex-utero-intrapartum-treatment-in-a-growth-restricted-fetus-with-tracheal-atresia
#10
S Kyle Gonzales, Steven Goudy, Kara Prickett, Jane Ellis
Congenital high airway obstruction syndrome (CHAOS) encompasses a heterogeneous group of pathologies leading to poor lung development and difficulty oxygenating the newborn after delivery. While previously uniformly fatal, the ex utero intrapartum therapy (EXIT) procedure has provided a method to treat these patients and provide an airway to potentiate survival. We present a patient diagnosed prenatally with CHAOS secondary to tracheal atresia complicated by severe intra-uterine growth restriction (IUGR) who was successfully delivered via an EXIT procedure at 33-weeks...
February 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29439909/prediction-of-outcome-in-asphyxiated-newborns-treated-with-hypothermia-is-a-mri-scoring-system-described-before-the-cooling-era-still-useful
#11
Fatema Al Amrani, Jaclyn Marcovitz, Priscille-Nice Sanon, May Khairy, Christine Saint-Martin, Michael Shevell, Pia Wintermark
AIM: To determine whether an MRI scoring system, which was validated in the pre-cooling era, can still predict the neurodevelopmental outcome of asphyxiated newborns treated with hypothermia at 2 years of age. PATIENTS AND METHOD: We conducted a retrospective cohort study of asphyxiated newborns treated with hypothermia. An MRI scoring system, which was validated in the pre-cooling era, was used to grade the severity of brain injury on the neonatal brain MRI. Their neurodevelopment was assessed around 2 years of age; adverse outcome included cerebral palsy, global developmental delay, and/or epilepsy...
January 31, 2018: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/29439297/state-of-south-dakota-s-child-2017
#12
Ann L Wilson, Tyler Hemmingson, Brad Randall
There was a slight decrease in 2016 from 2015 in the total number of live births in South Dakota, but it was the fifth consecutive year that there were more than 12,000 newborns in the state. Nearly one-quarter of South Dakota's births represent minority populations mirroring what is observed nationally. Infant mortality in South Dakota dropped to its lowest ever rate per 1,000 live births (4.8) in 2016. Fewer births of less than 500 g newborns, increased survival of very low birth weight newborns, and a decrease in deaths due to congenital anomalies contributed to this low mortality rate...
January 2018: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/29433937/long-term-improvement-of-neurological-signs-and-metabolic-dysfunction-in-a-mouse-model-of-krabbe-s-disease-after-global-gene-therapy
#13
Michael S Marshall, Yazan Issa, Benas Jakubauskas, Monika Stoskute, Vince Elackattu, Jeffrey N Marshall, Wil Bogue, Duc Nguyen, Zane Hauck, Emily Rue, Subha Karumuthil-Melethil, Violeta Zaric, Maarten Bosland, Richard B van Breemen, Maria I Givogri, Steven J Gray, Stephen J Crocker, Ernesto R Bongarzone
We report a global adeno-associated virus (AAV)9-based gene therapy protocol to deliver therapeutic galactosylceramidase (GALC), a lysosomal enzyme that is deficient in Krabbe's disease. When globally administered via intrathecal, intracranial, and intravenous injections to newborn mice affected with GALC deficiency (twitcher mice), this approach largely surpassed prior published benchmarks of survival and metabolic correction, showing long-term protection of demyelination, neuroinflammation, and motor function...
January 17, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29423186/assessment-of-health-facility-capacity-to-provide-newborn-care-in-bangladesh-haiti-malawi-senegal-and-tanzania
#14
Rebecca Winter, Jennifer Yourkavitch, Wenjuan Wang, Lindsay Mallick
Background: Despite the importance of health facility capacity to provide comprehensive care, the most widely used indicators for global monitoring of maternal and child health remain contact measures which assess women's use of services only and not the capacity of health facilities to provide those services; there is a gap in monitoring health facilities' capacity to provide newborn care services in low and middle income countries. Methods: In this study we demonstrate a measurable framework for assessing health facility capacity to provide newborn care using open access, nationally-representative Service Provision Assessment (SPA) data from the Demographic Health Surveys Program...
December 2017: Journal of Global Health
https://www.readbyqxmd.com/read/29423185/does-health-facility-service-environment-matter-for-the-receipt-of-essential-newborn-care-linking-health-facility-and-household-survey-data-in-malawi
#15
Liliana Carvajal-Aguirre, Vrinda Mehra, Agbessi Amouzou, Shane M Khan, Lara Vaz, Tanya Guenther, Maggie Kalino, Nabila Zaka
Background: Health facility service environment is an important factor for newborns survival and well-being in general and in particular in high mortality settings such as Malawi where despite high coverage of essential interventions, neonatal mortality remains high. The aim of this study is to assess whether the quality of the health service environment at birth is associated with quality of care received by the newborn. Methods: We used data from the Malawi Millennium Development Goals Endline household survey conducted as part of MICS survey program and Service Provision Assessment Survey carried out in 2014...
December 2017: Journal of Global Health
https://www.readbyqxmd.com/read/29423183/does-postnatal-care-have-a-role-in-improving-newborn-feeding-a-study-in-15-sub-saharan-african-countries
#16
Shane M Khan, Ilene S Speizer, Kavita Singh, Gustavo Angeles, Nana Ay Twum-Danso, Pierre Barker
Background: Breastfeeding is known as a key intervention to improve newborn health and survival while prelacteal feeds (liquids other than breastmilk within 3 days of birth) represents a departure from optimal feeding practices. Recent programmatic guidelines from the WHO and UNICEF outline the need to improve newborn feeding and points to postnatal care (PNC) as a potential mechanism to do so. This study examines if PNC and type of PNC provider are associated with key newborn feeding practices: breastfeeding within 1 day and prelacteal feeds...
December 2017: Journal of Global Health
https://www.readbyqxmd.com/read/29423181/skilled-attendant-at-birth-and-newborn-survival-in-sub-saharan-africa
#17
Agbessi Amouzou, Meng Ziqi, Liliana Carvajal-Aguirre, John Quinley
Background: Recent studies have shown higher neonatal mortality among births delivered by a skilled attendant at birth (SAB) compared to those who were not in sub-Saharan African countries. Deaths during the neonatal period are concentrated in the first 7 days of life, with about one third of these deaths occurring during the first day of life. We reassessed the relationship between SAB and neonatal mortality by distinguishing deaths on the first day of life from those on days 2-27. Methods: We used data on births in the past five years from recent demographic and health survey (DHS) between 2010 and 2014 in 20 countries in sub-Saharan Africa...
December 2017: Journal of Global Health
https://www.readbyqxmd.com/read/29423178/gap-between-contact-and-content-in-maternal-and-newborn-care-an-analysis-of-data-from-20-countries-in-sub-saharan-africa
#18
Liliana Carvajal-Aguirre, Agbessi Amouzou, Vrinda Mehra, Meng Ziqi, Nabila Zaka, Holly Newby
Background: Over the last decade, coverage of maternal and newborn health indicators used for global monitoring and reporting have increased substantially but reductions in maternal and neonatal mortality have remained slow. This has led to an increased recognition and concern that these standard globally agreed upon measures of antenatal care (ANC), skilled birth attendance (SBA) and postnatal care (PNC) only capture the level of contacts with the health system and provide little indication of actual content of services received by mothers and their newborns...
December 2017: Journal of Global Health
https://www.readbyqxmd.com/read/29408912/effect-of-maternal-height-on-caesarean-section-and-neonatal-mortality-rates-in-sub-saharan-africa-an-analysis-of-34-national-datasets
#19
Esther Arendt, Neha S Singh, Oona M R Campbell
RATIONALE: The lifecycle perspective reminds us that the roots of adult ill-health may start in-utero or in early childhood. Nutritional and infectious disease insults in early life, the critical first 1000 days, are associated with stunting in childhood, and subsequent short adult stature. There is limited or no opportunity for stunted children above 2 years of age to experience catch-up growth. Some previous research has shown short maternal height to lead to adverse birth outcomes...
2018: PloS One
https://www.readbyqxmd.com/read/29399120/significance-of-dynamic-evolution-of-tnf-%C3%AE-il-6-and-intestinal-fatty-acid-binding-protein-levels-in-neonatal-necrotizing-enterocolitis
#20
Zhaohui Li, Lei Sheng
To study the significance of dynamic evolution of serum tumor necrosis factor-α (TNF-α), interleukin 6 (IL-6) and intestinal fatty acid-binding protein (I-FABP) levels in neonatal necrotizing enterocolitis (NEC). A total of 45 NEC child patients, 45 non-NEC child patients and 45 healthy newborns were enrolled. After the day age, weight, gestational week and delivery mode were matched, the serum TNF-α, IL-6 and I-FABP levels at 6, 24 and 72 h after admission were measured via ELISA method, and their correlations with prognosis were analyzed...
February 2018: Experimental and Therapeutic Medicine
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