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Newborn survival

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https://www.readbyqxmd.com/read/28214215/immunoexpression-of-gadd45%C3%AE-in-the-myocardium-of-newborns-experiencing-perinatal-hypoxia
#1
Mona Adalgisa Simões, Francisco Cesar Pabis, Ana Karyn Ehrenfried de Freitas, Marina Luise Viola de Azevedo, Daiane Cristine Martins Ronchi, Lucia de Noronha
AIM: Among the several organs affected by perinatal hypoxia, the heart plays a central role, with cell death caused mainly by apoptosis. One of the biomarkers most often linked to hypoxia-derived apoptosis of cardiomyocytes in animals is Gadd45β. From the published literature, Gadd45β is proposed as a biomarker of hypoxia-induced lesion in cardiomyocytes, both in vitro, as well as in animal models. Our study suggests that this protein can be used as an early biomarker of cell damage in neonate's cardiomyocytes (humans specimens), a process that can ultimately lead to apoptosis...
January 31, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28212393/infant-mortality-and-morbidity-associated-with-preterm-and-small-for-gestational-age-births-in-southern-mozambique-a-retrospective-cohort-study
#2
Alberto L García-Basteiro, Llorenç Quintó, Eusebio Macete, Azucena Bardají, Raquel González, Arsenio Nhacolo, Betuel Sigauque, Charfudin Sacoor, María Rupérez, Elisa Sicuri, Quique Bassat, Esperança Sevene, Clara Menéndez
BACKGROUND: Preterm and small for gestational age (SGA) births have been associated with adverse outcomes during the first stages of life. We evaluated the morbidity and mortality associated with preterm and SGA births during the first year of life in a rural area of Southern Mozambique. METHODS: This is a retrospective cohort study using previously collected data from children born at the Manhiça District Hospital in two different periods (2003-2005 and 2010-2012)...
2017: PloS One
https://www.readbyqxmd.com/read/28209771/hearing-loss-in-children-with-asymptomatic-congenital-cytomegalovirus-infection
#3
Tatiana M Lanzieri, Winnie Chung, Marily Flores, Peggy Blum, A Chantal Caviness, Stephanie R Bialek, Scott D Grosse, Jerry A Miller, Gail Demmler-Harrison
OBJECTIVES: To assess the prevalence, characteristics, and risk of sensorineural hearing loss (SNHL) in children with congenital cytomegalovirus infection identified through hospital-based newborn screening who were asymptomatic at birth compared with uninfected children. METHODS: We included 92 case-patients and 51 controls assessed by using auditory brainstem response and behavioral audiometry. We used Kaplan-Meier survival analysis to estimate the prevalence of SNHL, defined as ≥25 dB hearing level at any frequency and Cox proportional hazards regression analyses to compare SNHL risk between groups...
February 16, 2017: Pediatrics
https://www.readbyqxmd.com/read/28203322/congenital-ichthyosis-a-case-treated-successfully-with-acitretin
#4
Selvi Gulasi
INTRODUCTION: Lamellar ichthyosis (collodion baby) is a cornification disorder classified under the category of autosomal recessive congenital ichthyosis and characterized by hyperkeratosis. Early-stage retinoid treatment has been shown to improve survival in these patients. In this article, a lamellar ichthyosis case is presented of an infant who had the symptoms at birth and was treated successfully with acitretin. CASE PRESENTATION: A term newborn infant presented after delivery...
October 2016: Iranian Journal of Pediatrics
https://www.readbyqxmd.com/read/28193719/brain-specific-ablation-of-efr3a-promotes-adult-hippocampal-neurogenesis-via-the-brain-derived-neurotrophic-factor-pathway
#5
Qi Qian, Qiuji Liu, Dongming Zhou, Hongyu Pan, Zhiwei Liu, Fangping He, Suying Ji, Dongpi Wang, Wangxiao Bao, Xinyi Liu, Zhaoling Liu, Heng Zhang, Xiaoqin Zhang, Ling Zhang, Mingkai Wang, Ying Xu, Fude Huang, Benyan Lao, Binggui Sun
Efr3 is a newly identified plasma membrane protein and plays an important role in the phosphoinositide metabolism on the plasma membrane. However, although it is highly expressed in the brain, the functional significance of Efr3 in the brain is not clear. In the present study, we generated Efr3a(f/f) mice and then crossed them with Nestin-Cre mice to delete Efr3a, one of the Efr3 isoforms, specifically in the brain. We found that brain-specific ablation of Efr3a promoted adult hippocampal neurogenesis by increasing survival and maturation of newborn neurons without affecting their dendritic tree morphology...
February 13, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28188219/distinct-effects-of-mir-210-reduction-on-neurogenesis-increased-neuronal-survival-of-inflammation-but-reduced-proliferation-associated-with-mitochondrial-enhancement
#6
Ludmila A Voloboueva, Xiaoyun Sun, Lijun Xu, Yi-Bing Ouyang, Rona G Giffard
Neurogenesis is essential to brain development, and plays a central role in the response to brain injury. Stroke and head trauma stimulate proliferation of endogenous neural stem cells (NSC). However, the survival of young neurons is sharply reduced by post-injury inflammation. Cellular mitochondria are critical to successful neurogenesis and are a major target of inflammatory injury. Mitochondrial protection was shown to improve survival of young neurons. This study tested whether reducing cellular microRNA-210 (miR-210) would enhance mitochondrial function and improve survival of young murine neurons under inflammatory conditions...
February 10, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28182029/very-severe-spinal-muscular-atrophy-type-0
#7
Suleiman Al Dakhoul
This case report describes a rare phenotype of very severe spinal muscular atrophy (SMA) in a newborn who presented with reduced fetal movements in utero and significant respiratory distress at birth. The patient was homozygously deleted for exon 7 and exon 8 of the survival motor neuron gene 1. Very severe SMA should be considered in the differential diagnosis of respiratory distress at birth, and more research should be dedicated to investigate the genetic determinants of its widely variable phenotypes.
January 2017: Avicenna Journal of Medicine
https://www.readbyqxmd.com/read/28177391/effect-of-oral-supplementation-with-different-energy-boosters-in-newborn-piglets-on-pre-weaning-mortality-growth-and-serological-levels-of-igf-i-and-igg
#8
R Muns, M Nuntapaitoon, P Tummaruk
Oral supplements are commonly used in commercial herds to improve energy status and passive immune acquisition of newborn piglets. However, there is little scientific evidence on the efficacy of oral supplements for piglets. The objective of this experiment was to study the effects of 2 oral supplementation products on piglet pre-weaning mortality and growth. A total of 62 litters (749 piglets) were distributed according to the sow's parity among 3 treatments: 1) CONTROL group, no oral supplementation to piglets; 2) EN group, light piglets (LP: birth BW ≤ 1...
January 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28168185/optimal-chest-compression-rate-and-compression-to-ventilation-ratio-in-delivery-room-resuscitation-evidence-from-newborn-piglets-and-neonatal-manikins
#9
REVIEW
Anne Lee Solevåg, Georg M Schmölzer
Cardiopulmonary resuscitation (CPR) duration until return of spontaneous circulation (ROSC) influences survival and neurologic outcomes after delivery room (DR) CPR. High quality chest compressions (CC) improve cerebral and myocardial perfusion. Improved myocardial perfusion increases the likelihood of a faster ROSC. Thus, optimizing CC quality may improve outcomes both by preserving cerebral blood flow during CPR and by reducing the recovery time. CC quality is determined by rate, CC to ventilation (C:V) ratio, and applied force, which are influenced by the CC provider...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28153657/fertility-treatments-and-pediatric-neoplasms-of-the-offspring-results-of-a-population-based-cohort-with-a%C3%A2-median-follow-up-of-10-years
#10
Tamar Wainstock, Asnat Walfisch, Ilana Shoham-Vardi, Idit Segal, Avi Harlev, Ruslan Sergienko, Daniella Landau, Eyal Sheiner
OBJECTIVE: Studies have questioned the long-term health effects of offspring conceived after fertility treatments. METHODS: We aimed to evaluate whether an association exists between mode of conception (in vitro fertilization, ovulation induction, or spontaneous pregnancy) and neoplasm risk (both benign and malignant tumors) among the offspring; we observed the offspring for up to 18 years. STUDY DESIGN: A population-based cohort analysis was performed that compared the risk for neoplasms among children (up to the age of 18 years) based on mode of conception...
January 30, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28150915/multicenter-retrospective-study-on-management-and-outcome-of-newborns-affected-by-surgical-necrotizing-enterocolitis
#11
Silvana Federici, Lorenzo DE Biagi, Simona Straziuso, Ernesto Leva, Giulia Brisighelli, Girolamo Mattioli, Luca Pio, Pietro Bagolan, Giorgia Totonelli, Bruno Noccioli, Elisa Severi, Pierluigi Lelli Chiesa, Gabriele Lisi, Antonino Tramontano, Carolina DE Chiara, Carmine Del Rossi, Giovanni Casadio, Mario Messina, Rossella Angotti, Antonino Appignani, Mirko Bertozzi, Fabio Rossi, Valeria Gabriele, Andrea Franchella, Veronica Zocca
BACKGROUND: Necrotizing enterocolitis (NEC) is the most common surgical emergency in newborns and it is still a leading cause of death despite the improvements reached in the management of the critically ill neonate. The purpose of this study was to evaluate risks factors, surgical treatments and outcome of surgical NEC. METHODS: We retrospectively evaluated a multicentric group of 184 patients with surgical NEC over a period of 5 years (2008-2012). Indications to operation were modified NEC Bell stages IIIA or IIIB...
February 1, 2017: Minerva Chirurgica
https://www.readbyqxmd.com/read/28143615/coxsackievirus-b4-vertical-transmission-in-a-murine-model
#12
Hela Jaïdane, Aymen Halouani, Habib Jmii, Firas Elmastour, Moncef Mokni, Mahjoub Aouni
BACKGROUND: Life-threatening infections with type B Coxsackieviruses (CV-B) are frequently encountered among newborns and are partly attributed to vertically-transmitted virus. Our current study investigates this alternative way of contamination by CV-B, using a mouse model. METHODS: Pregnant Swiss mice were intraperitoneally inoculated with CV-B4 E2 at gestational day 10(G) or 17G. Dams and offspring were monitored for mortality and morbidity, and sampled at different time-points to document the infection and explore eventual vertical transmission...
January 31, 2017: Virology Journal
https://www.readbyqxmd.com/read/28141859/studies-of-hvc-plasticity-in-adult-canaries-reveal-social-effects-and-sex-differences-as-well-as-limitations-of-multiple-markers-available-to-assess-adult-neurogenesis
#13
Olesya T Shevchouk, Gregory F Ball, Charlotte A Cornil, Jacques Balthazart
In songbirds, neurogenesis in the song control nucleus HVC is sensitive to the hormonal and social environment but the dynamics of this process is difficult to assess with a single exogenous marker of new neurons. We simultaneously used three independent markers to investigate HVC neurogenesis in male and female canaries. Males were castrated, implanted with testosterone and housed either alone (M), with a female (M-F) or with another male (M-M) while females were implanted with 17β-estradiol and housed with a male (F-M)...
2017: PloS One
https://www.readbyqxmd.com/read/28131490/prediction-of-3-to-5-month-outcomes-from-signs-of-acute-bilirubin-toxicity-in-newborn-infants
#14
Salma Z El Houchi, Iman Iskander, Rasha Gamaleldin, Amira El Shenawy, Iman Seoud, Hazem Abou-Youssef, Richard P Wennberg
OBJECTIVE: To evaluate the ability of the bilirubin-induced neurologic dysfunction (BIND) score to predict residual neurologic and auditory disability and to document the relationship of BIND score to total serum bilirubin (TSB) concentration. STUDY DESIGN: The BIND score (assessing mental status, muscle tone, and cry patterns) was obtained serially at 6- to 8-hour intervals in 220 near-term and full-term infants with severe hyperbilirubinemia. Neurologic and/or auditory outcomes at 3-5 months of age were correlated with the highest calculated BIND score...
January 25, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28122653/delivery-as-trauma-a-prospective-time-cohort-study-of-maternal-and-perinatal-mortality-in-rural-cambodia
#15
Chandy Houy, Sam Ol Ha, Margit Steinholt, Eystein Skjerve, Hans Husum
OBJECTIVE: The majority of maternal and perinatal deaths are preventable, but still women and newborns die due to insufficient Basic Life Support in low-resource communities. Drawing on experiences from successful wartime trauma systems, a three-tier chain-of-survival model was introduced as a means to reduce rural maternal and perinatal mortality. METHODS: A study area of 266 villages in landmine-infested Northwestern Cambodia were selected based on remoteness and poverty...
January 26, 2017: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/28122592/barriers-and-enablers-of-health-system-adoption-of-kangaroo-mother-care-a-systematic-review-of-caregiver-perspectives
#16
Emily R Smith, Ilana Bergelson, Stacie Constantian, Bina Valsangkar, Grace J Chan
BACKGROUND: Despite improvements in child survival in the past four decades, an estimated 6.3 million children under the age of five die each year, and more than 40% of these deaths occur in the neonatal period. Interventions to reduce neonatal mortality are needed. Kangaroo mother care (KMC) is one such life-saving intervention; however it has not yet been fully integrated into health systems around the world. Utilizing a conceptual framework for integration of targeted health interventions into health systems, we hypothesize that caregivers play a critical role in the adoption, diffusion, and assimilation of KMC...
January 25, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28118087/identification-of-a-peptide-for-systemic-brain-delivery-of-a-morpholino-oligonucleotide-in-mouse-models-of-spinal-muscular-atrophy
#17
Fazel Shabanpoor, Suzan M Hammond, Frank Abendroth, Gareth Hazell, Matthew J A Wood, Michael J Gait
Splice-switching antisense oligonucleotides are emerging treatments for neuromuscular diseases, with several splice-switching oligonucleotides (SSOs) currently undergoing clinical trials such as for Duchenne muscular dystrophy (DMD) and spinal muscular atrophy (SMA). However, the development of systemically delivered antisense therapeutics has been hampered by poor tissue penetration and cellular uptake, including crossing of the blood-brain barrier (BBB) to reach targets in the central nervous system (CNS)...
January 24, 2017: Nucleic Acid Therapeutics
https://www.readbyqxmd.com/read/28110749/contribution-of-syncytins-and-other-endogenous-retroviral-envelopes-to-human-placenta-pathologies
#18
P-A Bolze, M Mommert, F Mallet
Fusion, proliferation, angiogenesis, immune tolerance, and tissue survival are some of the critical functions involved in the physiological and pathological processes of placenta development. Strikingly, some of these properties are shared by envelope glycoproteins of retroviruses. Part of the overall retroviral world, the human retroviral heritage consists of hundred thousands of elements representing a huge amount of genetic material as compared to our 25,000 genes, whereas only a few tenths of retroviral loci still contain envelope genes exhibiting large open reading frames...
2017: Progress in Molecular Biology and Translational Science
https://www.readbyqxmd.com/read/28107100/newborn-weight-loss-during-birth-hospitalization-and-breastfeeding-outcomes-through-age-1-month
#19
Valerie J Flaherman, Eric W Schaefer, Michael K Kuzniewicz, Sherian Li, Eileen Walsh, Ian M Paul
BACKGROUND: Weight loss is universal for exclusively breastfed newborns in the first few days after birth. Many newborns exclusively breastfed during birth hospitalization receive formula in the first month after discharge and thus cease exclusive breastfeeding. However, the relationship between early weight loss and subsequent cessation of breastfeeding and exclusive breastfeeding is unknown. Research aim: This study aimed to determine the relationship between newborn weight loss and duration and exclusivity of breastfeeding among newborns breastfed exclusively during the birth hospitalization...
February 2017: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/28104124/enhancing-survival-of-human-hepatocytes-by-neonatal-thymectomy-and-partial-hepatectomy-in-micro-miniature-pigs
#20
H C Hsu, S Enosawa, T Yamazaki, S Tohyama, J Fujita, K Fukuda, E Kobayashi
BACKGROUND: With the goal of in vivo cultivation of human hepatocytes that have not been sufficient in full differentiation in vitro, the advantage of neonatal thymectomy was verified on expansion of xenogeneic human hepatocyte in the micro-miniature pig (MMP). METHODS: The thymus was excised immediately after the birth of the MMPs via cesarean section. Newborns were fed by artificial feeding under specific pathogen-free conditions. The thymectomized and nonthymectomized littermates were transplanted with human hepatocytes via a portal vein with or without partial hepatectomy at the MMP adult stage...
January 2017: Transplantation Proceedings
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