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Newborn survival

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https://www.readbyqxmd.com/read/29666679/intrauterine-fetal-blood-transfusion-descriptive-study-of-the-first-four-years-experience-in-oman
#1
Arwa Z Al-Riyami, Mouza Al-Salmani, Sabria N Al-Hashami, Sabah Al-Mahrooqi, Ali Al-Marhoobi, Sumaiya Al-Hinai, Saif Al-Hosni, Sathiya M Panchatcharam, Zainab A Al-Arimi
Objectives: Haemolytic disease of the fetus and newborn (HDFN) causes hydrops fetalis . The successful treatment of HDFN has been reported with intrauterine blood transfusion (IUT). This study aimed to describe the initial experience with IUT procedures in Oman. Methods: This retrospective observational study took place at the Royal Hospital and Sultan Qaboos University Hospital Blood Bank, Muscat, Oman, and included all women who underwent IUT procedures in Oman between March 2012 and March 2016...
February 2018: Sultan Qaboos University Medical Journal
https://www.readbyqxmd.com/read/29661562/initial-metabolic-profiles-are-associated-with-7-day-survival-among-infants-born-at-22-25-weeks-of-gestation
#2
Scott P Oltman, Elizabeth E Rogers, Rebecca J Baer, James G Anderson, Martina A Steurer, Matthew S Pantell, J Colin Partridge, Larry Rand, Kelli K Ryckman, Laura L Jelliffe-Pawlowski
OBJECTIVE: To evaluate the association between early metabolic profiles combined with infant characteristics and survival past 7 days of age in infants born at 22-25 weeks of gestation. STUDY DESIGN: This nested case-control consisted of 465 singleton live births in California from 2005 to 2011 at 22-25 weeks of gestation. All infants had newborn metabolic screening data available. Data included linked birth certificate and mother and infant hospital discharge records...
April 13, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29660115/a-working-model-for-hypothermic-neuroprotection
#3
Guido Wassink, Joanne O Davidson, Christopher A Lear, Sandra E Juul, Frances Northington, Laura Bennet, Alistair J Gunn
Therapeutic hypothermia significantly improves survival without disability in near-term and full-term newborns with moderate-severe hypoxic-ischaemic encephalopathy. However, hypothermic neuroprotection is incomplete. The challenge now is to find ways to further improve outcomes. One major limitation to progress is that the specific mechanisms of hypothermia are only partly understood. Evidence supports the concept that therapeutic cooling suppresses multiple extracellular death signals, including intracellular pathways of apoptotic and necrotic cell death and inappropriate microglial activation...
April 16, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29627578/selective-alteration-of-adult-hippocampal-neurogenesis-and-impaired-spatial-pattern-separation-performance-in-the-rsk2-deficient-mouse-model-of-coffin-lowry-syndrome
#4
Charlotte Castillon, Steeve Lunion, Nathalie Desvignes, André Hanauer, Serge Laroche, Roseline Poirier
Adult neurogenesis is involved in certain hippocampus-dependent cognitive functions and is linked to psychiatric diseases including intellectual disabilities. The Coffin-Lowry syndrome (CLS) is a developmental disorder caused by mutations in the Rsk2 gene and characterized by intellectual disabilities associated with growth retardation. How RSK2-deficiency leads to cognitive dysfunctions in CLS is however poorly understood. Here, using Rsk2 Knock-Out mice, we characterized the impact of RSK2 deficiency on adult hippocampal neurogenesis in vivo...
April 5, 2018: Neurobiology of Disease
https://www.readbyqxmd.com/read/29614695/treatment-algorithm-for-infants-diagnosed-with-spinal-muscular-atrophy-through-newborn-screening
#5
Jacqueline Glascock, Jacinda Sampson, Amanda Haidet-Phillips, Anne Connolly, Basil Darras, John Day, Richard Finkel, R Rodney Howell, Katherine Klinger, Nancy Kuntz, Thomas Prior, Perry B Shieh, Thomas Crawford, Doug Kerr, Jill Jarecki
BACKGROUND: Spinal muscular atrophy (SMA) is an autosomal recessive disease characterized by the degeneration of alpha motor neurons in the spinal cord, leading to muscular atrophy. SMA is caused by deletions or mutations in the survival motor neuron 1 gene (SMN1). In humans, a nearly identical copy gene, SMN2, is present. Because SMN2 has been shown to decrease disease severity in a dose-dependent manner, SMN2 copy number is predictive of disease severity. OBJECTIVE: To develop a treatment algorithm for SMA-positive infants identified through newborn screening based upon SMN2 copy number...
March 26, 2018: Journal of Neuromuscular Diseases
https://www.readbyqxmd.com/read/29614674/optical-depolarization-of-dcx-expressing-cells-promoted-cognitive-recovery-and-maturation-of-newborn-neurons-via-the-wnt-%C3%AE-catenin-pathway
#6
Ming-Liang Zhao, Shi-Jin Chen, Xiao-Hong Li, Li-Na Wang, Feng Chen, Shi-Jiang Zhong, Cheng Yang, Sheng-Kai Sun, Jian-Jun Li, Hua-Jiang Dong, Yue-Qing Dong, Yi Wang, Chong Chen
Electrical excitability by membrane depolarization is crucial for survival and maturation of newborn cells in the dentate gyrus of the hippocampus. However, traditional technology for membrane depolarization lacks temporal and spatial precision. Optogenetics can be used to activate channelrhodopsin-2 (ChR2), allowing cationic current to depolarize genetically targeted cells. In this study, we used ChR2-EGFP driven by doublecortin (DCX) to promote survival and maturation of newborn cells in the dentate gyrus after traumatic brain injury (TBI)...
March 28, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29614628/comorbidities-in-aging-patients-with-sickle-cell-disease
#7
Samir K Ballas
Sickle cell disease (SCD) in general and sickle cell anemia in particular is a highly complex disorder both at the molecular and clinical levels. Although the molecular lesion is a single-point mutation, the sickle gene is pleiotropic in nature causing multiple phenotypic expressions that constitute the various complications of the disease. Moreover, despite the fact that SCD is a chronic malady, its manifestations are both acute and chronic. The former include, among other things, the recurrent vaso-occlusive crises (its hallmark) and acute chest syndrome...
2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29604341/maternal-smoking-during-pregnancy-and-the-risk-of-pediatric-cardiovascular-diseases-of-the-offspring-a-population-based-cohort-study-with-up-to-18-years-of-follow-up
#8
Noa Leybovitz-Haleluya, Tamar Wainstock, Daniella Landau, Eyal Sheiner
BACKGROUND: Cigarette smoke is a well-known reproductive toxicant. We aimed to study the long-term effect of cigarette smoking during pregnancy on the risk for childhood cardiovascular morbidity of the offspring. METHODS: A population-based cohort analysis was performed comparing total and subtypes of cardiovascular related pediatric hospitalizations among offspring of smoking mothers versus offspring of non-smoking mothers. The analysis included all singletons born between the years 1999-2014...
March 28, 2018: Reproductive Toxicology
https://www.readbyqxmd.com/read/29603269/nutrition-delivery-during-pediatric-extracorporeal-membrane-oxygenation-therapy
#9
Lindsey B Armstrong, Katelyn Ariagno, Craig D Smallwood, Charles Hong, Mary Arbuthnot, Nilesh M Mehta
BACKGROUND: Macronutrient delivery during pediatric ECMO therapy can be challenging. We examined predictors of nutrient delivery in the first 2 weeks of extracorporeal membrane oxygenation (ECMO) therapy in the pediatric intensive care unit (ICU). METHODS: Details of macronutrient delivery were recorded in children (newborn-18 years of age) who survived 24 hours after cannulation to ECMO over a 3-year period (2012-2015). RESULTS: We analyzed data from 54 consecutive eligible patients, 43% female, with median (interquartile range) ECMO duration of 8...
March 30, 2018: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29602923/-the-role-of-genes-of-renin-angiotensin-system-in-the-development-of-adverse-outcomes-of-treatment-in-severe-intraventricular-hemorrhages-in-premature-infants
#10
Наталия И Гасюк, Наталия С Артемова, Елена М Ковалева, Валерий И Похилько, Галина А Соловьева
OBJECTIVE: Introduction: Intraventricular hemorrhage (IVH) causes increased morbidity and mortality in premature infants and is associated with adverse neurological outcomes. The aim of the research is to confirm the role of genes of renin-angiotensin system in the development of adverse outcomes of treatment of severe IVC in preterm. PATIENTS AND METHODS: Materials and methods: A prospective study was conducted, which included 58 premature infants (average birth weight 1016...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29601456/infant-hiv-free-survival-in-the-era-of-universal-antiretroviral-therapy-for-pregnant-and-breastfeeding-women-a-community-based-cohort-study-from-rural-zambia
#11
Benjamin H Chi, Wilbroad Mutale, Jennifer Winston, Winifreda Phiri, Joan T Price, Angel Mwiche, Helen Ayles, Jeffrey S A Stringer
BACKGROUND: Lifelong antiretroviral therapy (ART) is now recommended for all HIV-infected pregnant and breastfeeding women; however, few have described overall infant outcomes in this new era for the prevention of mother-to-child HIV transmission (PMTCT). METHODS: As part of an assessment of PMTCT program impact, we enrolled a prospective cohort study in four predominantly rural districts in Zambia. HIV-infected mothers and their newborns (≤30 days old) were recruited and followed at 6 weeks, 6 months, and 12 months postpartum; infant specimens were tested via HIV DNA PCR...
March 27, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29593485/-till-death-do-us-part-a-potential-irreversible-link-between-aberrant-cell-cycle-control-and-neurodegeneration-in-the-adult-olfactory-bulb
#12
REVIEW
Saad Omais, Carine Jaafar, Noël Ghanem
Adult neurogenesis (AN) is an ongoing developmental process that generates newborn neurons in the olfactory bulb (OB) and the hippocampus (Hi) throughout life and significantly contributes to brain plasticity. Adult neural stem and progenitor cells (aNSPCs) are relatively limited in number and fate and are spatially restricted to the subventricular zone (SVZ) and the subgranular zone (SGZ). During AN, the distinct roles played by cell cycle proteins extend beyond cell cycle control and constitute key regulatory mechanisms involved in neuronal maturation and survival...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29593295/dexras1-is-a-homeostatic-regulator-of-exercise-dependent-proliferation-and-cell-survival-in-the-hippocampal-neurogenic-niche
#13
Pascale Bouchard-Cannon, Christopher Lowden, Dennison Trinh, Hai-Ying M Cheng
Adult hippocampal neurogenesis is highly responsive to exercise, which promotes the proliferation of neural progenitor cells and the integration of newborn granule neurons in the dentate gyrus. Here we show that genetic ablation of the small GTPase, Dexras1, suppresses exercise-induced proliferation of neural progenitors, alters survival of mitotic and post-mitotic cells in a stage-specific manner, and increases the number of mature newborn granule neurons. Dexras1 is required for exercise-triggered recruitment of quiescent neural progenitors into the cell cycle...
March 28, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29589971/clinical-considerations-in-the-hematopoietic-stem-cell-transplant-management-of-primary-immunodeficiencies
#14
Alexandra Laberko, Andrew R Gennery
Primary immunodeficiencies (PID) are genetic immune disorders causing increased predisposition to infections and autoimmunity. The only curative procedure is hematopoietic stem cell transplantation (HSCT), results from which have improved dramatically since 2000. Complications remain a serious issue, especially in HLA non-identical transplantation. In PID patients, persistent infection and autoimmunity with end-organ damage cause particular problems with approach to transplantation. This article examines these, emphasising approach to management and consequences...
March 28, 2018: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/29582948/-advances-in-fetal-therapy-in-complicated-monochorionic-pregnancies-and-in-severe-congenital-diaphragmatic-hernia-five-years-experience
#15
Yuval Gielchinsky, Dan V Valsky, Nili Yanai, Firas J Abdeljawad, Mazen A Muhaisen, Dan Arbell, Yehuda Ginosar, Orna Ben-Yosef, Orite Winograd, Benjamin Bar-Oz, Simcha Yagel, Smadar Eventov-Friedman
INTRODUCTION: : Minimally invasive fetal therapeutic procedures reduce the morbidity and mortality in monochorionic (MC) twins and in fetuses with congenital diaphragmatic hernia (CDH). MC pregnancies share their blood systems due to communicating vessels over their single placenta and may develop specific complications: Twin-to-Twin transfusion syndrome (TTTS), Selective intrauterine growth restriction (sIUGR), Twin Anemia-Polycythemia Sequence (TAPS), Twin Reverse Arterial Perfusion Syndrome (TRAP) or anomalies in one...
March 2018: Harefuah
https://www.readbyqxmd.com/read/29582399/perinatal-asphyxia-and-brain-development-mitochondrial-damage-without-anatomical-or-cellular-losses
#16
Jean Pierre Mendes Lima, Danielle Rayêe, Thaia Silva-Rodrigues, Paula Ribeiro Paes Pereira, Ana Paula Miranda Mendonca, Clara Rodrigues-Ferreira, Diego Szczupak, Anna Fonseca, Marcus F Oliveira, Flavia Regina Souza Lima, Roberto Lent, Antonio Galina, Daniela Uziel
Perinatal asphyxia remains a significant cause of neonatal mortality and is associated with long-term neurodegenerative disorders. In the present study, we evaluated cellular and subcellular damages to brain development in a model of mild perinatal asphyxia. Survival rate in the experimental group was 67%. One hour after the insult, intraperitoneally injected Evans blue could be detected in the fetuses' brains, indicating disruption of the blood-brain barrier. Although brain mass and absolute cell numbers (neurons and non-neurons) were not reduced after perinatal asphyxia immediately and in late brain development, subcellular alterations were detected...
March 26, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29580082/association-of-amniotic-uric-acid-glucose-lactate-and-creatinine-concentrations-and-lactate-creatinine-ratio-with-newborn-survival-in-small-sized-dogs-preliminary-results
#17
Barbara Bolis, Paola Scarpa, Alessandro Rota, Tiziana Vitiello, Maria Cristina Veronesi
In order to define the normal composition of canine amniotic fluid and to detect differences between surviving and non-surviving newborn puppies, the present study determined the uric acid, glucose, lactate and creatinine concentrations and the lactate to creatinine ratio in amniotic fluids collected during elective Caesarean section from small-sized purebred bitches. The possible relationship between newborn survival and the studied parameters, as well as the effects of maternal parity, fetal gender and Apgar score were assessed...
March 2018: Acta Veterinaria Hungarica
https://www.readbyqxmd.com/read/29579278/subchronic-manganese-exposure-impairs-neurogenesis-in-the-adult-rat-hippocampus
#18
Sherleen Xue-Fu Adamson, Xubo Shen, Wendy Jiang, Vivien Lai, Xiaoting Wang, Jonathan H Shannahan, Jason R Cannon, Jinhui Chen, Wei Zheng
Adult neurogenesis takes place in the brain subventricular zone (SVZ) in the frontal cortex and subgranular zone (SGZ) in the hippocampal dentate gyrus (HDG), and functions to supply newborn neurons for normal brain functionality. Subchronic Mn exposure is known to disrupt adult neurogenesis in the SVZ. This study was designed to determine whether Mn exposure disturbed neurogenesis within the adult HDG. Adult rats (10 weeks old) received a single dose of BrdU at the end of 4-wk Mn exposure to label the proliferating cells...
March 21, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29577271/anatomic-relationship-of-internal-cervical-os-to-maternal-bladder-in-pregnancies-at-low-and-high-risk-of-preterm-delivery
#19
Daniel Faustin, Sabia Akbar, Tatiana Bihun, Erica Gomez, Derek Liang, Petr Itzhak, Ralph Ruggiero, Joylin Devadoss
Preterm delivery correlates with perinatal death and long-term neurologic sequelae in surviving newborns.1,3 Cervical changes demonstrated by transvaginal sonogram can help to predict preterm labor.3,4 Shalev et al.4 have reported on the position of the internal cervical os relative to the maternal bladder in prediction of preterm delivery. We did the present retrospective study to test the hypothesis that women at risk of preterm delivery are more likely to display a low-set internal cervical os than are those at low risk of preterm labor and delivery...
March 25, 2018: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29570556/province-wide-biliary-atresia-home-screening-program-in-british-columbia-evaluation-of-first-two-years
#20
Jessica P Woolfson, Richard A Schreiber, Alison E Butler, Julie MacFarlane, Janusz Kaczorowski, Lisa Masucci, Stirling Bryan, J P Collet
BACKGROUND: Biliary atresia (BA), a rare newborn liver disease, is the leading cause of liver-related death in children. Early disease recognition and timely surgical Kasai hepatoportoenterostomy (KP) offers long-term survival without liver transplant. Universal BA screening in Taiwan using infant stool color cards (ISCCs) has proven effectiveness. We report our experience with ISCC BA screening in a province-wide program in British Columbia (BC). OBJECTIVES: To assess program performance and cost from launch April 1, 2014-March 31, 2016...
March 22, 2018: Journal of Pediatric Gastroenterology and Nutrition
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