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Traumatic brain injury randomized

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https://www.readbyqxmd.com/read/29770146/effects-of-20-hz-repetitive-transcranial-magnetic-stimulation-on-disorders-of-consciousness-a-resting-state-electroencephalography-study
#1
Fangping He, Min Wu, Fanxia Meng, Yangfan Hu, Jian Gao, Zhongqin Chen, Wangxiao Bao, Kehong Liu, Benyan Luo, Gang Pan
Repetitive transcranial magnetic stimulation (rTMS) has been proposed as an experimental approach for the treatment of disorders of consciousness (DOC). To date, there has been little research into the use of rTMS in DOC and the therapeutic effects have been variously documented. This study aimed to examine the effects of 20 Hz rTMS on the electroencephalography (EEG) reactivity and clinical response in patients with DOC and to explore the neuromodulatory effects of high-frequency rTMS. In this randomized, sham-controlled, crossover study, real or sham 20 Hz rTMS was applied to the left primary motor cortex (M1) of patients with DOC for 5 consecutive days...
2018: Neural Plasticity
https://www.readbyqxmd.com/read/29766125/trauma-early-mortality-prediction-tool-tempt-for-assessing-28-day-mortality
#2
Ryan C Kunitake, Lucy Z Kornblith, Mitchell Jay Cohen, Rachael A Callcut
Background: Prior mortality prediction models have incorporated severity of anatomic injury quantified by Abbreviated Injury Severity Score (AIS). Using a prospective cohort, a new score independent of AIS was developed using clinical and laboratory markers present on emergency department presentation to predict 28-day mortality. Methods: All patients (n=1427) enrolled in an ongoing prospective cohort study were included. Demographic, laboratory, and clinical data were recorded on admission...
2018: Trauma surgery & acute care open
https://www.readbyqxmd.com/read/29752909/systematic-review-of-caregiver-and-dyad-interventions-following-adult-traumatic-brain-injury
#3
REVIEW
Natalie Kreitzer, Brad G Kurowski, Tamilyn Bakas
OBJECTIVE: To describe and synthesize the existing literature of published adult TBI family caregiver and dyad intervention studies. Traumatic brain injuries (TBIs) are common and have a significant long-term impact, with some characterizing TBI as a chronic condition. Informal family caregivers of adults with TBI suffer from high rates of burnout, depression, fatigue, anxiety, lower subjective well-being, and poorer levels of physical health compared to non-caregivers. There is a critical gap in the understanding of interventions designed to address the impact of TBI on adult patients and their family caregivers...
May 9, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29742960/amantadine-did-not-positively-impact-cognition-in-chronic-traumatic-brain-injury-a-multi-site-randomized-controlled-trial
#4
Flora Hammond, Mark Sherer, James F Malec, Ross D Zafonte, Sureyya Dikmen, Jennifer A Bogner, Kathleen Bell, Jason Barber, Nancy Temkin
Despite limited evidence to support the use of amantadine to enhance cognitive function after traumatic brain injury, the clinical use for this purpose is highly prevalent and is often based on inferred belief systems. The purpose of this study was to assess effect of amantadine on cognition among individuals with a history of traumatic brain injury and behavioral disturbance employing a parallel-group, randomized, double-blind, placebo-controlled trial of amantadine 100 mg twice daily vs placebo for 60 days...
May 10, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29742587/exploratory-application-of-neuropharmacometabolomics-in-severe-childhood-traumatic-brain-injury
#5
Fanuel T Hagos, Philip E Empey, Pengcheng Wang, Xiaochao Ma, Samuel M Poloyac, Hülya Bayır, Patrick M Kochanek, Michael J Bell, Robert S B Clark
OBJECTIVES: To employ metabolomics-based pathway and network analyses to evaluate the cerebrospinal fluid metabolome after severe traumatic brain injury in children and the capacity of combination therapy with probenecid and N-acetylcysteine to impact glutathione-related and other pathways and networks, relative to placebo treatment. DESIGN: Analysis of cerebrospinal fluid obtained from children enrolled in an Institutional Review Board-approved, randomized, placebo-controlled trial of a combination of probenecid and N-acetylcysteine after severe traumatic brain injury (Trial Registration NCT01322009)...
May 7, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29737870/the-effect-of-donepezil-on-the-cognitive-ability-early-in-the-course-of-recovery-from-traumatic-brain-injury
#6
Kelsey A Campbell, Richard E Kennedy, Robert C Brunner, Sean D Hollis, Ross A Lumsden, Thomas A Novack
OBJECTIVE: To investigate the effect of donepezil on cognitive ability in patients who have sustained a traumatic brain injury (TBI). We hypothesized that donepezil, an acetylcholinesterase inhibitor, would enhance cognitive recovery beyond that of usual care in an acute rehabilitation facility. METHODS: This retrospective, longitudinal analysis included 55 patients who were non-randomly prescribed donepezil during acute care and compared them to 74 patients who received usual rehabilitation treatment...
May 8, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29734566/hyperbaric-oxygen-for-post-concussive-symptoms-in-united-states-military-service-members-a-randomized-clinical-trial
#7
Lindell K Weaver, Steffanie H Wilson, Anne S Lindblad, Susan Churchill, Kayla Deru, Robert C Price, Chris S Williams, William W Orrison, James M Walker, Anna Meehan, Susan Mirow
Background: In prior military randomized trials, participants with persistent symptoms after mild traumatic brain injury (TBI) reported improvement regardless of receiving hyperbaric oxygen (HBO₂) or sham intervention. This study's objectives were to identify outcomes for future efficacy trials and describe changes by intervention. Methods: This Phase II, randomized, double-blind, sham-controlled trial enrolled military personnel with mild TBI and persistent post-concussive symptoms...
March 2018: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
https://www.readbyqxmd.com/read/29730104/feasibility-of-online-traumatic-brain-injury-prognostic-crash-as-a-predictor-of-mortality
#8
Ahmad Faried, Ferry C Satriawan, Muhammad Z Arifin
INTRODUCTION: Traumatic brain injury (TBI) is a major cause of mortality in many countries. According to the World Health Organization, traffic crashes have become a leading cause of death, with as many as 1.25 million deaths worldwide in 2013. Further, a 2013 global road safety report listed 68 low-to-middle income countries that had an increased mortality rate due to traffic accidents. The aim of this study is to analyze the feasibility of an online prognostic model from the Medical Research Council (MRC) Corticosteroids Randomization after Significant Head Injury (CRASH) trial collaborators to be used in our center...
May 3, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29729380/effect-of-infusion-speed-of-7-5-hypertonic-saline-on-brain-edema-in-patients-with-craniocerebral-injury-an-experimental-study
#9
Zhenzhen Jiang, Hongmei Xu, Meilin Wang, Zefu Li, Xinyang Su, Xiaoli Li, Zhenzhu Li, Xuexin Han
This study firstly used a rat traumatic brain injury model to compare the therapeutic effects of different intravenous infusion speed of 7.5% hypertonic saline (HS). Then the authors applied different delivery rate of 7.5% HS to two groups of patients to figure out the optimal infusion rates. A total of 100 rats were randomly divided into control group, group A (7.5% HS 6 ml/h), group B (7.5% HS 3 ml/h), and group C (7.5% HS 2 ml/h). All rats were established for the brain injury model. A total of 30 patients were selected and randomly divided into group A (250 ml/h) and group B (125 ml/h), with 15 cases in each group...
May 2, 2018: Gene
https://www.readbyqxmd.com/read/29725828/comparison-of-effect-of-dexmedetomidine-and-lidocaine-on-intracranial-and-systemic-hemodynamic-response-to-chest-physiotherapy-and-tracheal-suctioning-in-patients-with-severe-traumatic-brain-injury
#10
Shalendra Singh, Rajendra Singh Chouhan, Ashish Bindra, Nayani Radhakrishna
PURPOSE: Chest physiotherapy and tracheal suction cause sympathetic stimulation and increase heart rate (HR), mean arterial pressure (MAP) and intracranial pressure (ICP) which may have deleterious effect in the head injured. We planned to compare the effect of intravenous dexmedetomidine and lidocaine on intracerebral and systemic hemodynamic response to chest physiotherapy (CP) and tracheal suctioning (TS) in patients with severe traumatic brain injury (sTBI). METHODS: Prospective, randomized study in patients with sTBI, 18-60 years of age, undergoing mechanical ventilation and intraparenchymal ICP monitoring...
May 3, 2018: Journal of Anesthesia
https://www.readbyqxmd.com/read/29720544/advantages-of-virtual-reality-in-the-rehabilitation-of-balance-and-gait-systematic-review
#11
REVIEW
Desiderio Cano Porras, Petra Siemonsma, Rivka Inzelberg, Gabriel Zeilig, Meir Plotnik
BACKGROUND: Virtual reality (VR) has emerged as a therapeutic tool facilitating motor learning for balance and gait rehabilitation. The evidence, however, has not yet resulted in standardized guidelines. The aim of this study was to systematically review the application of VR-based rehabilitation of balance and gait in 6 neurologic cohorts, describing methodologic quality, intervention programs, and reported efficacy. METHODS: This study follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses...
May 2, 2018: Neurology
https://www.readbyqxmd.com/read/29713142/ketamine-ameliorates-oxidative-stress-induced-apoptosis-in-experimental-traumatic-brain-injury-via-the-nrf2-pathway
#12
Jinwei Liang, Shanhu Wu, Wenxi Xie, Hefan He
Background: Ketamine can act as a multifunctional neuroprotective agent by inhibiting oxidative stress, cellular dysfunction, and apoptosis. Although it has been proven to be effective in various neurologic disorders, the mechanism of the treatment of traumatic brain injury (TBI) is not fully understood. The aim of this study was to investigate the neuroprotective function of ketamine in models of TBI and the potential role of the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway in this putative protective effect...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29710314/auditory-perceptual-assessment-of-fluency-in-typical-and-neurologically-disordered-speech
#13
Nelly Penttilä, Anna-Maija Korpijaakko-Huuhka, Ray D Kent
Purpose: The aim of this study is to investigate how speech fluency in typical and atypical speech is perceptually assessed by speech-language pathologists (SLPs). Our research questions were as follows: (a) How do SLPs rate fluency in speakers with and without neurological communication disorders? (b) Do they differentiate the speaker groups? and (c) What features do they hear impairing speech fluency? Method: Ten SLPs specialized in neurological communication disorders volunteered as expert judges to rate 90 narrative speech samples on a Visual Analogue Scale (see Kempster, Gerratt, Verdolini Abbott, Barkmeier-Kraemer, & Hillman, 2009; p...
April 18, 2018: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/29707422/modafinil-for-the-improvement-of-patient-outcomes-following-traumatic-brain-injury
#14
REVIEW
Amne Borghol, Michael Aucoin, Ifeanyichukwu Onor, Dana Jamero, Fadi Hawawini
Objective : The authors sought to assess the literature evidence on the efficacy of modafinil use in patients with fatigue or excessive daytime sleepiness (EDS) secondary to traumatic brain injury (TBI). Method of Research : A literature search of Medline and PubMed was performed using the EBSCOhost database. Primary literature, observational studies, meta-analyses, case reports, and systematic reviews were assessed for content regarding modafinil and psychostimulant use in patients with TBI. Of the 23 articles collected, three randomized, controlled studies, three observational studies, one case report, and two systematic reviews gave a description of modafinil use in TBI patients...
April 1, 2018: Innovations in Clinical Neuroscience
https://www.readbyqxmd.com/read/29701561/granulocyte-colony-stimulating-factor-administration-for-neurological-improvement-in-patients-with-postrehabilitation-chronic-incomplete-traumatic-spinal-cord-injuries-a-double-blind-randomized-controlled-clinical-trial
#15
Nazi Derakhshanrad, Hooshang Saberi, Mir Saeed Yekaninejad, Mohammad Taghi Joghataei, Abdolreza Sheikhrezaei
OBJECTIVE Granulocyte-colony stimulating factor (G-CSF) is a major growth factor for activation and differentiation of granulocyte colonies in the bone marrow. This cytokine has been widely and safely employed in different conditions over many years. The purpose of this study was to investigate the efficacy of G-CSF administration for traumatic spinal cord injury (TSCI). METHODS This double-blind parallel randomized, placebo-controlled, clinical trial, a phase III study, was performed from June 2013 to June 2016 in the Brain and Spinal Cord Injury Research (BASIR) center at Tehran University of Medical Sciences (TUMS)...
April 27, 2018: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29693126/neuroprotective-effects-of-dexmedetomidine-on-traumatic-brain-injury-involvement-of-neuronal-apoptosis-and-hsp70-expression
#16
Man-He Zhang, Xiu-Min Zhou, Jian-Zhong Cui, Kai-Jie Wang, Yan Feng, Hong-Ao Zhang
The aim of the present study was to investigate the protective effect of dexmedetomidine (Dex) on traumatic brain injury (TBI), and further evaluate whether the underlying neuroprotective mechanisms are associated with neurological apoptosis and the expression of 70 kDa heat shock protein (HSP70) in the hippocampus. A total of 90 adult male Sprague‑Dawley rats were randomly assigned into 3 groups (n=30/group): Sham, TBI and Dex groups. The rat models of TBI were established using a modified weight‑drop device and Dex (15 µg/kg) was intravenously administered immediately following TBI...
April 19, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29690927/effects-of-transcranial-led-therapy-on-the-cognitive-rehabilitation-for-diffuse-axonal-injury-due-to-severe-acute-traumatic-brain-injury-study-protocol-for-a-randomized-controlled-trial
#17
João Gustavo Rocha Peixoto Dos Santos, Ana Luiza Costa Zaninotto, Renato Amaro Zângaro, Ana Maria Costa Carneiro, Iuri Santana Neville, Almir Ferreira de Andrade, Manoel Jacobsen Teixeira, Wellingson Silva Paiva
BACKGROUND: Photobiomodulation describes the use of red or near-infrared light to stimulate or regenerate tissue. It was discovered that near-infrared wavelengths (800-900 nm) and red (600 nm) light-emitting diodes (LED) are able to penetrate through the scalp and skull and have the potential to improve the subnormal cellular activity of compromised brain tissue. Different experimental and clinical studies were performed to test LED therapy for traumatic brain injury (TBI) with promising results...
April 24, 2018: Trials
https://www.readbyqxmd.com/read/29690837/neutralization-of-interleukin-1%C3%AE-following-diffuse-traumatic-brain-injury-in-the-mouse-attenuates-the-loss-of-mature-oligodendrocytes
#18
Johanna Flygt, Karsten Ruscher, Amanda Norberg, Anis Mir, Hermann Gram, Fredrik Clausen, Niklas Marklund
Traumatic brain injury (TBI) commonly results in injury to the components of the white matter tracts, causing post-injury cognitive deficits. The myelin-producing oligodendrocytes (OLs) are vulnerable to TBI although may plausibly be replaced by proliferating oligodendrocyte progenitor cells (OPCs). The cytokine interleukin-1β (IL-1β) is a key mediator of the complex inflammatory response, and when neutralized in experimental TBI behavioral outcome was improved. To evaluate the role of IL-1β on OL cell death and OPC proliferation, 116 adult male mice subjected to sham injury or the central fluid percussion injury (cFPI) model of traumatic axonal injury, were analyzed at 2, 7 and 14 days post-injury...
April 25, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29683728/healthcare-providers-attitudes-and-behaviours-related-to-paediatric-mild-traumatic-brain-injury-results-from-the-2014-docstyles-survey
#19
Kelly Sarmiento, Zoe Donnell, Rosanne Hoffman, Bethany Tennant
OBJECTIVE: Explore healthcare providers' experiences managing mTBI and better understand their use of mTBI assessment tools and guidelines. Cross-sectional Methods: A random sample of 1,760 healthcare providers responded to the web-based DocStyles survey between June 18 and 30, 2014. The sample included family/general practitioners, internists, pediatricians, and nurse practitioners who reported seeing pediatric patients. We examined their experiences with mTBI to identify opportunities to increase preparedness and improve management of mTBI...
April 23, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29676680/midline-central-fluid-percussion-model-of-traumatic-brain-injury-in-pediatric-and-adolescent-rats
#20
Rachel K Rowe, Jordan L Harrison, Timothy W Ellis, P David Adelson, Jonathan Lifshitz
OBJECTIVE Experimental traumatic brain injury (TBI) models hold significant validity to the human condition, with each model replicating a subset of clinical features and symptoms. TBI is the leading cause of mortality and morbidity in children and teenagers; thus, it is critical to develop preclinical models of these ages to test emerging treatments. Midline fluid percussion injury (FPI) might best represent mild and diffuse clinical brain injury because of the acute behavioral deficits, the late onset of behavioral morbidities, and the absence of gross histopathology...
April 20, 2018: Journal of Neurosurgery. Pediatrics
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