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Traumatic brain injury randomized

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https://www.readbyqxmd.com/read/29343158/placebo-effects-in-traumatic-brain-injury
#1
Ginger Polich, Mary Alexis Iaccarino, Ted J Kaptchuk, Leon Morales-Quezada, Ross Zafonte
In recent years, several randomized controlled trials evaluating pharmaceutical treatments for traumatic brain injury (TBI) have failed to demonstrate efficacy over placebo, with both active and placebo arms improving at comparable rates. These findings could be viewed in opposing ways, suggesting on the one hand failure of the tested outcome, but representing on the other, evidence of robust placebo effects in TBI. In this article, we examine several of the primary psychological processes driving placebo effects (verbal suggestion, cognitive re-framing, interpersonal interactions, conditioning, therapeutic alliance, anxiety reduction) as well as placebo neurobiology (top-down cortical regulation, reward system activation, dopaminergic and serotonergic neurotransmission)...
January 17, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29337171/is-early-tracheostomy-better-for-severe-traumatic-brain-injury-a-meta-analysis
#2
Qin Lu, Yonglin Xie, Xunchen Qi, Xinwei Li, Shuxu Yang, Yirong Wang
OBJECTIVE: Tracheotomy have been proven to be benefit for the patients requiring prolonged mechanical ventilation. However, whether early tracheotomy (less than 10 days) could also improve the outcome of severe traumatic brain injury (TBI) patient (GCS≤8) remains controversial. The aim of this study was trying to clarify this question. METHODS: We searched four databases (PubMed, Web of Science, Elsevier and Cochrane Library) for articles comparing the outcome of early tracheostomy with late tracheostomy or prolonged intubation on the severe TBI patients...
January 11, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29327125/icariin-improves-cognitive-impairment-after-traumatic-brain-injury-by-enhancing-hippocampal-acetylation
#3
Zi-Gang Zhang, Xin Wang, Jin-Hai Zai, Cai-Hua Sun, Bing-Chun Yan
OBJECTIVE: To examine the effect of icariin (ICA) on the cognitive impairment induced by traumatic brain injury (TBI) in mice and the underlying mechanisms related to changes in hippocampal acetylation level. METHODS: The modifified free-fall method was used to establish the TBI mouse model. Mice with post-TBI cognitive impairment were randomly divided into 3 groups using the randomised block method (n=7): TBI (vehicle-treated), low-dose (75 mg/kg) and high-dose (150 mg/kg) of ICA groups...
January 9, 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29325484/risk-of-erectile-dysfunction-after-traumatic-brain-injury-a-nationwide-population-based-cohort-study-in-taiwan
#4
Yun-Ju Yang, Wu-Chien Chien, Chi-Hsiang Chung, Kun-Ting Hong, Yi-Lin Yu, Dueng-Yuan Hueng, Yuan-Hao Chen, Hsin-I Ma, Hsin-An Chang, Yu-Chen Kao, Hui-Wen Yeh, Nian-Sheng Tzeng
INTRODUCTION: In our study, we aimed to investigate the association between a traumatic brain injury (TBI) and subsequent erectile dysfunction (ED). This is a population-based study using the claims dataset from The National Health Insurance Research Database. METHODS: We included 72,642 patients with TBI aged over 20 years, retrospectively, selected from the longitudinal health insurance database during 2000-2010, according to the ICD-9-CM. The control group consisted of 217,872 patients without TBI that were randomly chosen from the database at a ratio of 1:3, with age- and index year matched...
January 1, 2018: American Journal of Men's Health
https://www.readbyqxmd.com/read/29324173/the-risk-of-deterioration-in-gcs13-15-patients-with-traumatic-brain-injury-identified-by-computed-tomography-imaging-a-systematic-review-and-meta-analysis
#5
Carl Marincowitz, Fiona E Lecky, William Townend, Aditya Borakati, Andrea Fabbri, Trevor A Sheldon
The optimal management of mild traumatic brain injury (TBI) patients with injuries identified by computed tomography (CT) brain scan is unclear. Some guidelines recommend hospital admission for an observation period of at least 24 h. Others argue that selected lower-risk patients can be discharged from the Emergency Department (ED). The objective of our review and meta-analysis was to estimate the risk of death, neurosurgical intervention, and clinical deterioration in mild TBI patients with injuries identified by CT brain scan, and assess which patient factors affect the risk of these outcomes...
January 11, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29310710/photobiomodulation-using-low-level-laser-therapy-lllt-for-patients-with-chronic-traumatic-brain-injury-a-randomized-controlled-trial-study-protocol
#6
Guilherme da Cruz Ribeiro Poiani, Ana Luiza Zaninotto, Ana Maria Costa Carneiro, Renato Amaro Zangaro, Afonso Shiguemi Inoue Salgado, Rodolfo Borges Parreira, Almir Ferreira de Andrade, Manoel Jacobsen Teixeira, Wellingson Silva Paiva
BACKGROUND: Photobiomodulation using low-level laser therapy (LLLT) has been tested as a new technique to optimize recovery of patients with traumatic brain injury (TBI). The aim of this study is to evaluate inhibitory attentional control after 18 sessions of active LLLT and compare with the placebo group (sham LLLT). Our exploratory analysis will evaluate the efficacy of the active LLLT on verbal and visuospatial episodic memory, executive functions (working memory, verbal and visuospatial fluency, attentional processes), and anxiety and depressive symptoms compared to the sham group...
January 8, 2018: Trials
https://www.readbyqxmd.com/read/29303450/subcutaneous-bone-flap-storage-after-emergency-craniectomy-cost-effectiveness-and-rate-of-resorption
#7
Griffin Ernst, Fares Qeadan, Andrew P Carlson
OBJECTIVE Decompressive craniectomy is used for uncontrolled intracranial pressure in traumatic brain injury and malignant hemispheric stroke. Subcutaneous preservation of the autologous bone flap in the abdomen is a simple, portable technique but has largely been abandoned due to perceived concerns of resorption. The authors sought to characterize their experience with subcutaneous preservation of the bone flap and cranioplasty. METHODS The authors performed a retrospective single-institution review of subcutaneous preservation of the autologous bone flap after decompressive craniectomy from 2005 to 2015...
January 5, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29303438/prospective-randomized-blinded-and-placebo-controlled-study-of-cerebrolysin-dose-response-effects-on-long-term-functional-outcomes-in-a-rat-model-of-mild-traumatic-brain-injury
#8
Yanlu Zhang, Michael Chopp, Zheng Gang Zhang, Yi Zhang, Li Zhang, Mei Lu, Talan Zhang, Stefan Winter, Hemma Brandstätter, Asim Mahmood, Ye Xiong
OBJECTIVE Cerebrolysin is a neuropeptide preparation that mimics the properties of neurotrophic factors and has had beneficial effects in the treatment of neurodegenerative diseases, stroke, and traumatic brain injury (TBI). To further evaluate treatment schemes, the authors assessed the dose-response of Cerebrolysin on functional improvement in a rat model of mild TBI (mTBI). METHODS This dose-response study was a prospective, randomized, blinded, and placebo-controlled preclinical experiment. Male Wistar adult rats, subjected to mTBI induced by a closed head impact, were treated randomly with 0 (saline as placebo), 0...
January 5, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29284857/to-compare-the-effect-of-two-different-doses-of-dexmedetomidine-on-the-attenuation-of-airway-and-pressor-response-during-tracheostomy-tube-change-in-traumatic-brain-injury-patients
#9
Abdul Alim Khan, Neeraj Kumar, Yashpal Singh, Atul Kumar Singh, Sharad Kumar Mathur
Background: Tracheostomy tube (TT) change is the common procedure in trauma Intensive Care Unit (ICU) and almost always associated with cough reflex, increase in blood pressure, and heart rate. Dexmedetomidine (DEX) is a selective α2-adrenergic receptor agonist well studied for the prevention of pressor response during laryngoscopy and extubation, but literature on prevention of pressor response during TT change is lacking. Aims: The aim of this study is to compare two doses (0...
October 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/29275788/a-systematic-review-of-anxiety-interventions-in-stroke-and-acquired-brain-injury-efficacy-and-trial-design
#10
Ho-Yan Yvonne Chun, Richard Newman, William N Whiteley, Martin Dennis, Gillian E Mead, Alan J Carson
OBJECTIVE: There is little randomized controlled trial (RCT) evidence to guide treatment for anxiety after stroke. We systematically reviewed RCTs of anxiety interventions in acquired brain injury (ABI) conditions including stroke and traumatic brain injury (TBI) in order to summarize efficacy and key aspects of trial design to help guide future RCTs. METHODS: We searched the Cochrane trial register, Medline, Embase, PsychInfo and CINAHL systematically up to August 2017...
January 2018: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/29251711/beta-blockers-in-critically-ill-patients-with-traumatic-brain-injury-results-from-a-multi-center-prospective-observational-aast-study
#11
Eric J Ley, Samuel D Leonard, Galinos Barmparas, Navpreet K Dhillon, Kenji Inaba, Ali Salim, Karen R OʼBosky, Danielle Tatum, Hooman Azmi, Chad G Ball, Paul T Engels, Julie A Dunn, Matthew M Carrick, Jonathan P Meizoso, Sarah Lombardo, Bryan A Cotton, Thomas J Schroeppel, Sandro Rizoli, David S J Chang, Luis Alejandro de León, Joao Rezende-Neto, Tomas Jacome, Jimmy Xiao, Gina Mallory, Krishnamurti Rao, Lars Widdel, Samuel Godin, Angela Coates, Leo Andrew Benedict, Raminder Nirula, Sanjeev Kaul, Tong Li
BACKGROUND: Beta blockers, a class of medications that inhibit endogenous catecholamines interaction with beta adrenergic receptors, are often administered to patients hospitalized after traumatic brain injury (TBI). We tested the hypothesis that beta blocker use after TBI is associated with lower mortality, and secondarily compared propranolol to other beta blockers. METHODS: The AAST Clinical Trial Group conducted a multi-institutional, prospective, observational trial in which adult TBI patients who required ICU admission were compared based on beta blocker administration...
December 14, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29251706/valproic-acid-induces-pro-survival-transcriptomic-changes-in-swine-subjected-to-traumatic-injury-and-hemorrhagic-shock
#12
Patrick E Georgoff, Vahagn C Nikolian, Gerald Higgins, Kiril Chtraklin, Hassan Eidy, Mohamed H Ghandour, Aaron Williams, Brian Athey, Hasan B Alam
BACKGROUND: Valproic acid (VPA) is a histone deacetylase inhibitor that improves outcomes in large animal models of trauma. However, its protective mechanism of action is not completely understood. We sought to characterize the genetic changes induced by VPA treatment following traumatic injuries. METHODS: Six female Yorkshire swine were subjected to traumatic brain injury (TBI, controlled cortical impact), polytrauma (liver and splenic laceration, rib fracture, rectus crush), and hemorrhagic shock (HS, 40% total blood volume)...
December 14, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29251705/human-adipose-derived-stem-cell-asc-treatment-modulates-cellular-protection-in-both-in-vitro-and-in-vivo-traumatic-brain-injury-models
#13
Nikolas S Kappy, Shaohua Chang, William M Harris, Michael Plastini, Telisha Ortiz, Ping Zhang, Joshua P Hazelton, Jeffrey P Carpenter, Spencer A Brown
BACKGROUND: Traumatic brain injury (TBI) is a common cause of morbidity and mortality in the civilian population. The purpose of this study is to examine the effect(s) of ASC treatment on cellular and functional recovery in TBI via both in vitro and in vivo methods. METHODS: Cultured neuroblastoma cells, SH-SY5Y, were scratched to mimic TBI in an in vitro model. The effect of ASC conditioned medium on cell death, mitochondrial function, and expression of inflammatory cytokines (TNF-α, IL-1β and IL-6) as well as apoptosis marker FAS was measured...
December 14, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29250027/derivation-of-a-three-biomarker-panel-to-improve-diagnosis-in-patients-with-mild-traumatic-brain-injury
#14
W Frank Peacock, Timothy E Van Meter, Nazanin Mirshahi, Kyle Ferber, Robert Gerwien, Vani Rao, Haris Iqbal Sair, Ramon Diaz-Arrastia, Frederick K Korley
Background: Nearly 5 million emergency department (ED) visits for head injury occur each year in the United States, of which <10% of patients show abnormal computed tomography (CT) findings. CT negative patients frequently suffer protracted somatic, behavioral, and neurocognitive dysfunction. Our goal was to evaluate biomarkers to identify mild TBI (mTBI) in patients with suspected head injury. Methods: An observational ED study of head-injured and control patients was conducted at Johns Hopkins University (HeadSMART)...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29248884/use-of-general-practice-before-and-after-mild-traumatic-brain-injury-a-nationwide-population-based-cohort-study-in-denmark
#15
Stine Fjendbo Galili, Bodil Hammer Bech, Claus Vestergaard, Morten Fenger-Gron, Jakob Christensen, Mogens Vestergaard, Jette Ahrensberg
OBJECTIVES: Traumatic brain injury (TBI) is commonly seen in the emergency department (ED). Approximately 85%-90% of TBIs are mild (mTBI). Some cause symptoms such as headache, dizziness, anxiety, blurred vision, insomnia and concentration difficulties, collectively known as postconcussion syndrome (PCS). Some studies suggest that recovery from mTBI is complete. Others find that symptoms persist for months, even years. The aim of this study was to describe the use of general practice, before and after mTBI, as a proxy for symptoms in a large cohort...
December 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/29238428/does-red-cell-distribution-width-predict-outcome-in-traumatic-brain-injury-comparison-to-corticosteroid-randomization-after-significant-head-injury
#16
Farid Sadaka, Nicholas Doctors, Tallia Pearson, Brian Snyders, Jacklyn O'Brien
Background: Traumatic brain injury (TBI) is a leading cause of death and disability. The role of red cell distribution width (RDW) as a prognostic biomarker for outcome in TBI patients is unknown. Based on the corticosteroid randomization after significant head injury (CRASH) trial database, a prognosis calculator (CRASH) has been developed for outcome prediction in TBI. The objectives of this study are to investigate the association between RDW on day 1 of TBI and outcome, and to compare outcome prediction from RDW to that from CRASH...
January 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29229396/albeit-nocturnal-rats-subjected-to-traumatic-brain-injury-do-not-differ-in-neurobehavioral-performance-whether-tested-during-the-day-or-night
#17
Peter J Niesman, Jiahui Wei, Megan J LaPorte, Lauren J Carlson, Kileigh L Nassau, Gina C Bao, Jeffrey P Cheng, Patricia de la Tremblaye, Naima Lajud, Corina O Bondi, Anthony E Kline
Behavioral assessments in rats are overwhelmingly conducted during the day, albeit that is when they are least active. This incongruity may preclude optimal performance. Hence, the goal of this study was to determine if differences in neurobehavior exist in traumatic brain injured (TBI) rats when assessed during the day vs. night. The hypothesis was that the night group would perform better than the day group on all behavioral tasks. Anesthetized adult male rats received either a cortical impact or sham injury and then were randomly assigned to either Day (1:00-3:00p...
December 8, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29229352/the-outcome-of-severe-traumatic-brain-injury-in-latin-america
#18
Robert H Bonow, Jason Barber, Nancy R Temkin, Walter Videtta, Carlos Rondina, Gustavo Petroni, Silvia Lujan, Victor Alanis, Gustavo La Fuente, Arturo Lavadenz, Roberto Merida, Manuel Jibaja, Luis Gonzáles, Antonio Falcao, Ricardo Romero, Sureyya Dikmen, James Pridgeon, Randall M Chesnut
Traumatic brain injury (TBI) disproportionately affects lower and middle income countries (LMIC). The factors influencing outcomes in LMIC have not been examined as rigorously as in higher-income countries (HIC). This study was conducted to examine clinical and demographic factors influencing TBI outcomes in Latin American LMIC. Data were prospectively collected during a randomized trial of intracranial pressure monitoring in severe TBI and a companion observational study. Participants were aged ≥ 13 years and admitted to study hospitals with GCS ≤ 8...
December 8, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29212562/a-randomised-controlled-trial-of-the-monoaminergic-stabiliser-osu6162-in-treatment-of-myalgic-encephalomyelitis-chronic-fatigue-syndrome
#19
Marie Karin Lena Nilsson, Olof Zachrisson, Carl-Gerhard Gottfries, Michael Matousek, Birgitta Peilot, Sara Forsmark, Robert Christiaan Schuit, Maria Lizzie Carlsson, Angelica Kloberg, Arvid Carlsson
OBJECTIVE: The monoaminergic stabiliser (-)-OSU6162 has in previous studies shown promising effects on mental fatigue after stroke and traumatic brain injury. This study investigated the safety and effectiveness of (-)-OSU6162 in patients with myalgic encephalomyelitis/chronic fatigue syndrome. METHODS: A total of 62 patients were randomly assigned to placebo or (-)-OSU6162. Primary outcomes were assessment on the mental fatigue scale (MFS) and the clinical global impression of change (CGI-C) scale...
December 7, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29212462/pharmacological-targeting-of-secondary-brain-damage-following-ischemic-or-hemorrhagic-stroke-traumatic-brain-injury-and-bacterial-meningitis-a-systematic-review-and-meta-analysis
#20
Thomas Beez, Hans-Jakob Steiger, Nima Etminan
BACKGROUND: The effectiveness of pharmacological strategies exclusively targeting secondary brain damage (SBD) following ischemic stroke, aneurysmal subarachnoid hemorrhage, aSAH, intracerebral hemorrhage (ICH), traumatic brain injury (TBI) and bacterial meningitis is unclear. This meta-analysis studied the effect of SBD targeted treatment on clinical outcome across the pathological entities. METHODS: Randomized, controlled, double-blinded trials on aforementioned entities with 'death' as endpoint were identified...
December 7, 2017: BMC Neurology
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