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Traumatic brain injury randomized

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https://www.readbyqxmd.com/read/28429354/the-role-of-the-hippocampus-and-the-function-of-calcitonin-gene-related-peptide-in-the-mechanism-of-traumatic-brain-injury-accelerating-fracture-healing
#1
Y Song, G-X Han, L Chen, Y-Z Zhai, J Dong, W Chen, T-S Li, H-Y Zhu
OBJECTIVE: This research attempts to identify the part the hippocampus plays in accelerated fracture-healing after traumatic brain injury as well as to test functions of calcitonin gene-related peptide (CGRP) during this process. MATERIALS AND METHODS: Experiments were carried out on Male Sprague-Dawley rats that were split into four groups at random: TBI-fracture group, fracture-only group, TBI-only group, and control group. In the first week, blood specimen would be drawn from rats among the groups except those of the control group at three-time points (24, 72 and 168 hours) post-damage...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28422894/impact-of-telephone-based-problem-solving-treatment-on-the-use-of-medical-and-psychological-services-in-the-military
#2
John S Richardson, Jesse R Fann, Kathleen R Bell, Nancy Temkin
OBJECTIVE: To explore the impact of problem-solving treatment (PST) for mild traumatic brain injury in active duty service members on the use of medical and psychological services. PARTICIPANTS: Service members who had a mild traumatic brain injury during their last deployment and enrolled in the CONcussion Treatment After Combat Trauma (CONTACT) study. DESIGN: Secondary analysis of a randomized clinical trial. Participants were assigned to telephone-based PST, or e-mailed or mailed education only over the course of 6 months...
April 18, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28421863/a-meta-analysis-of-task-related-influences-in-prospective-memory-in-traumatic-brain-injury
#3
Daniela Wong Gonzalez, Lori Buchanan
Prospective memory is the ability to remember to do something in the future and it is essential to every-day functional independence. Traumatic brain injury is associated with frequent and persistent prospective memory deficits. This study presents a review and meta-analysis investigating the effects of task parameters on prospective memory performance of individuals with TBI. Individual studies using continuous behavioural measures of prospective memory with a sample of adults with TBI and matched controls were included...
April 19, 2017: Neuropsychological Rehabilitation
https://www.readbyqxmd.com/read/28420282/exploring-predictors-of-treatment-outcome-in-cognitive-behavior-therapy-for-sleep-disturbance-following-acquired-brain-injury
#4
Sylvia Nguyen, Dean McKenzie, Adam McKay, Dana Wong, Shantha M W Rajaratnam, Gershon Spitz, Gavin Williams, Darren Mansfield, Jennie Ponsford
PURPOSE: To identify predictors of treatment response to cognitive behavior therapy (CBT) for sleep disturbance following acquired brain injury (ABI). METHODS: Classification and regression tree (CART) analysis was conducted on individual patient data from two pilot randomized controlled trials (RCTs): one in traumatic brain injury (TBI), the other in stroke. The combined sample comprised 32 participants; 15 receiving CBT and 17 allocated to treatment as usual (TAU)...
April 19, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28412305/memantine-improves-outcomes-after-repetitive-traumatic-brain-injury
#5
Zhengrong Mei, Jianhua Qiu, Sasha Alcon, Jumana Hashim, Alexander Rotenberg, Yan Sun, William P Meehan, Rebekah Mannix
Repetitive mild traumatic brain injury (rmTBI; e.g., sports concussions) is common and results in significant cognitive impairment. Targeted therapies for rmTBI are lacking, though evidence from other injury models indicates that targeting N-methyl-d-aspartate (NMDA) receptor (NMDAR)-mediated glutamatergic toxicity might mitigate rmTBI-induced neurologic deficits. However, there is a paucity of preclinical or clinical data regarding NMDAR antagonist efficacy in the rmTBI setting. To test whether NMDAR antagonist therapy improves outcomes after rmTBI, mice were subjected to rmTBI injury (4 injuries in 4 days) and randomized to treatment with the NMDA antagonist memantine or with vehicle...
April 12, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28407334/time-to-cranial-computerised-tomography-for-acute-traumatic-brain-injury-in-paediatric-patients-effect-of-the-shorter-stays-in-emergency-departments-target-in-new-zealand
#6
Peter G Jones, Bridget Kool, Stuart Dalziel, Michael Shepherd, James Le Fevre, Alana Harper, Susan Wells, Joanna Stewart, Elana Curtis, Papaarangi Reid, Shanthi Ameratunga
AIM: Timely access to computerised tomography (CT) for acute traumatic brain injuries (TBIs) facilitates rapid diagnosis and surgical intervention. In 2009, New Zealand introduced a mandatory target for emergency department (ED) stay such that 95% of patients should leave ED within 6 h of arrival. This study investigated whether this target influenced the timeliness of cranial CT scanning in children who presented to ED with acute TBI. METHODS: We retrospectively reviewed a random sample of charts of children <15 years with acute TBI from 2006 to 2012...
April 13, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/28406438/u-s-trends-of-ed-visits-for-pediatric-traumatic-brain-injuries-implications-for-clinical-trials
#7
Cheng Chen, Junxin Shi, Rachel M Stanley, Eric A Sribnick, Jonathan I Groner, Henry Xiang
Our goal in this paper was to use the 2006-2013 Nationwide Emergency Department Sample (NEDS) database to describe trends of annual patient number, patient demographics and hospital characteristics of pediatric traumatic brain injuries (TBI) treated in U.S. emergency departments (EDs); and to use the same database to estimate the available sample sizes for various clinical trials of pediatric TBI cases. National estimates of patient demographics and hospital characteristics were calculated for pediatric TBI...
April 13, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28400181/cognitive-behavior-therapy-to-treat-sleep-disturbance-and-fatigue-following-traumatic-brain-injury-a-pilot-randomized-controlled-trial
#8
Sylvia Nguyen, Adam McKay, Dana Wong, S M Rajaratnam, Gershon Spitz, Gavin Williams, Darren Mansfield, Jennie L Ponsford
OBJECTIVE: To evaluate the efficacy of adapted cognitive behavioral therapy (CBT) for sleep disturbance and fatigue in individuals with traumatic brain injury (TBI). DESIGN: Parallel two-group randomized controlled trial. SETTING: Outpatient therapy in the Melbourne metropolitan area. PARTICIPANTS: Twenty-four adults with history of TBI and clinically significant sleep and/or fatigue complaints were randomly allocated to an eight-session adapted CBT intervention or a treatment as usual (TAU) condition...
April 8, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28389109/problem-solving-following-traumatic-brain-injury-in-adolescence-associations-with-functional-outcomes
#9
Shari L Wade, Amy E Cassedy, Lauren E Fulks, H Gerry Taylor, Terry Stancin, Michael W Kirkwood, Keith O Yeates, Brad G Kurowski
OBJECTIVE: To examine the association of problem solving with functioning in youth with traumatic brain injury (TBI). DESIGN: Cross-sectional evaluation of pre-treatment data from a randomized clinical trial. SETTING: Four children's hospitals and one general hospital, with level 1 trauma units. PARTICIPANTS: Youth, ages 11 to 18, who sustained moderate or severe TBI in the past 18 months (n = 133). MAIN OUTCOME AND MEASURES: Problem-solving skills were assessed using the Social Problem Solving Inventory (SPSI) and the Dodge Social Information Processing Short Stories (SIP-SR)...
April 4, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28383947/the-effect-of-education-type-on-common-misconceptions-of-traumatic-brain-injury
#10
Monica L De Iorio, Susan A Nolan, Susan Teague
PURPOSE: In the current study, we investigated the effects of existing education materials-either a Traumatic Brain Injury (TBI) factsheet or personal stories of people with TBI-on undergraduate students' misconceptions and attributions about the causes of TBI-related behavior. METHOD: Undergraduate students (N = 164) were recruited through the university participant pool. The participants were randomly assigned to receive either a factsheet about TBI, personal stories of people with TBI, or a control reading...
April 6, 2017: Rehabilitation Psychology
https://www.readbyqxmd.com/read/28383475/alterations-in-bdnf-and-igf-1-protein-levels-following-penetrating-ballistic-like-brain-injury-in-rats
#11
Sindhu K Madathil, Ying Deng-Bryant, Bernard S Wilfred, Lai Yee Leung, Janice S Gilsdorf, Deborah A Shear
BACKGROUND: Brain derived neurotrophic factor (BDNF) and Insulin-like growth factor-1 (IGF-1) are essential for neuroplasticity and neuronal survival. Despite the importance of these endogenous factors in mediating post-traumatic recovery, little is known about their response after penetrating type traumatic brain injury (TBI). The objective of this study was to quantify the expression levels BDNF and IGF-1, two well-known neuroplasticity mediators, following penetrating ballistic-like brain injury (PBBI)...
April 5, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28382306/apolipoprotein-e-mimetic-peptide-cn-105-improves-outcomes-in-ischemic-stroke
#12
Tian Ming Tu, Brad J Kolls, Erik J Soderblom, Viviana Cantillana, Paul Durham Ferrell, M Arthur Moseley, Haichen Wang, Hana N Dawson, Daniel T Laskowitz
OBJECTIVE: At present, the absence of a pharmacological neuroprotectant represents an important unmet clinical need in the treatment of ischemic and traumatic brain injury. Recent evidence suggests that administration of apolipoprotein E mimetic therapies represent a viable therapeutic strategy in this setting. We investigate the neuroprotective and anti-inflammatory properties of the apolipoprotein E mimetic pentapeptide, CN-105, in a microglial cell line and murine model of ischemic stroke...
April 2017: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/28377323/brain-injury-results-in-lower-levels-of-melatonin-receptors-subtypes-mt1-and-mt2
#13
Nicole D Osier, Lan Pham, Bunny J Pugh, Ava Puccio, Dianxu Ren, Yvette P Conley, Sheila Alexander, C Edward Dixon
BACKGROUND: Traumatic brain injury (TBI) is a devastating and costly acquired condition that affects individuals of all ages, races, and geographies via a number of mechanisms. The effects of TBI on melatonin receptors remain unknown. PURPOSE: The purpose of this study is to explore whether endogenous changes in two melatonin receptor subtypes (MT1 and MT2) occur after experimental TBI. SAMPLE: A total of 25 adult male Sprague Dawley rats were used with 6 or 7 rats per group...
April 2, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28377252/impact-of-increased-football-field-width-on-player-high-speed-collision-rate
#14
Jacob R Joseph, Siri S Khalsa, Brandon W Smith, Paul Park
BACKGROUND: High-acceleration head impact is a known risk for mild traumatic brain injury (mTBI) based on studies using helmet accelerometry. In football, offensive and defensive players are at higher risk of mTBI due to increased speed of play. Other collision sport studies suggest that increased playing surface size may contribute to reductions in high-speed collisions. We hypothesized that wider football fields lead to a decreased rate of high-speed collisions. METHODS: Computer football game simulation was developed using MATLAB...
April 1, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28376667/environmental-enrichment-mitigates-deficits-after-repetitive-mild-tbi
#15
Xiaxia Liu, Jianhua Qiu, Sasha Alcon, Jumana Hashim, William Meehan, Rebekah Mannix
While environmental enrichment has been shown to improve functional and histologic outcomes in preclinical moderate-severe traumatic brain injury (TBI), there is a paucity of preclinical data regarding enrichment strategies in the setting of repetitive mild traumatic brain injury (rmTBI). Given the vast numbers of athletes who sustain rmTBI, the mounting evidence of the long-term and progressive sequelae of rmTBI, and the lack of targeted therapies to mitigate these sequelae, successful enrichment interventions in rmTBI could have large public health significance...
April 4, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28362914/understanding-hospital-volume-outcome-relationship-in-severe-traumatic-brain-injury
#16
Aziz S Alali, David Gomez, Victoria McCredie, Todd G Mainprize, Avery B Nathens
BACKGROUND: The hospital volume-outcome relationship in severe traumatic brain injury (TBI) population remains unclear. OBJECTIVE: To examine the relationship between volume of patients with severe TBI per hospital and in-hospital mortality, major complications, and mortality following a major complication (ie, failure to rescue). METHODS: In a multicenter cohort study, data on 9255 adults with severe TBI were derived from 111 hospitals participating in the American College of Surgeons Trauma Quality Improvement Program over 2009-2011...
April 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28353579/intensive-insulin-therapy-for-preventing-postoperative-infection-in-patients-with-traumatic-brain-injury-a-randomized-controlled-trial
#17
RANDOMIZED CONTROLLED TRIAL
Yan Wang, Jin-Ping Li, Ying-Lun Song, Qi-Huang Zhao
OBJECTIVE: To assess the effect of intensive insulin therapy (IIT) for preventing postoperative infection in patients with traumatic brain injury (TBI). METHODS: In total, 88 patients with TBI were randomly divided into 2 groups, 44 in each group. One group (group ITT) received IIT and the other group (group CIT) received conventional insulin therapy (CIT). This study was conducted between February 2013 and January 2016. Outcomes included infection rate, mortality, and neurological outcome (measured by the Glasgow Outcome Scale [GOS])...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28350181/effects-of-hemoglobin-level-on-the-early-postsurgical-cerebral-metabolism-in-patients-with-severe-to-traumatic-brain-injury
#18
Zhi-Yuan Xia, Yan-Jun Che, Jie-Min Luo, Ke Zhou, Wei Yang, Wen-Qing Zhang, Chun-Ming Sun
OBJECTIVE: The study aims to explore the effects of different levels of haemoglobin (Hb) on early cerebral metabolism in patients with postoperative severe traumatic brain injury (TBI) . METHOD: Fifty-nine patients were randomly divided into catheter oxygen group and ventilator-assisted respiratory group. Each group was subsequently divided into three subgroups basing on different Hb level: Hb ≤ 70 g/L subgroup, 71 g/L ≤ Hb≤90 g/L subgroup and Hb ≥ 91 g/L subgroup...
March 28, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28343797/early-brain-edema-is-a-predictor-of-in-hospital-mortality-in-traumatic-brain-injury
#19
Brian Tucker, Jill Aston, Megan Dines, Elena Caraman, Marianne Yacyshyn, Mary McCarthy, James E Olson
BACKGROUND: Identifying patients who may progress to a poor clinical outcome will encourage earlier appropriate therapeutic interventions. Brain edema may contribute to secondary injury in traumatic brain injury (TBI) and thus, may be a useful prognostic indicator. OBJECTIVE: We determined whether the presence of brain edema on the initial computed tomography (CT) scan of TBI patients would predict poor in-hospital outcome. METHODS: We performed a retrospective review of all trauma patients with nonpenetrating head trauma at a Level I Trauma Center...
March 23, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28338437/contralateral-peripheral-neurotization-for-a-hemiplegic-hindlimb-after-central-neurological-injury
#20
Mou-Xiong Zheng, Xu-Yun Hua, Su Jiang, Yan-Qun Qiu, Yun-Dong Shen, Wen-Dong Xu
OBJECTIVE Contralateral peripheral neurotization surgery has been successfully applied to rescue motor function of the hemiplegic upper extremity in patients with central neurological injury (CNI). It may contribute to strengthened neural pathways between the contralesional cortex and paretic limbs. However, the effect of this surgery in the lower extremities remains unknown. In the present study the authors explored the effectiveness and safety of contralateral peripheral neurotization in treating a hemiplegic lower extremity following CNI in adult rats...
March 24, 2017: Journal of Neurosurgery
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