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RANDOMIZED CONTROLLED TRIAL
Haidar M Al-Khazali, Rune H Christensen, Basit Ali Chaudhry, Anna G Melchior, Messoud Ashina, Rami Burstein, Håkan Ashina
BACKGROUND: Phosphodiesterase 3 (PDE-3) inhibition have been implicated in the neurobiologic underpinnings of migraine. Considering the clinical similarities between migraine and persistent post-traumatic headache (PPTH), we aimed to ascertain whether PDE-3 inhibition can elicit migraine-like headache in persons with PPTH. METHODS: We tested cilostazol, which inhibits PDE-3, in a randomized, double-blind, placebo-controlled, two-way crossover study involving persons with PPTH attributed to mild traumatic brain injury...
April 17, 2024: Journal of Headache and Pain
#2
REVIEW
Jia Chen, Yuanwei Dong, Hong Guo, Tianyu Zhao, Di Zhang, Song Jin
Post-traumatic brain injury cognitive disorder(PTBICD) is one of the common symptoms of TBI survivors, severely limiting their life and rehabilitation progress. Repetitive transcranial magnetic stimulation (rTMS) has been shown to modulate cognition in a non-invasive manner while there are inconsistencies in previous studies. A comprehensive systematic review of rTMS treatment in patients with PTBICD is warranted. To evaluate the efficacy and safety of rTMS + cognitive training(CT) in enhancing cognitive function among PTBICD patients...
April 16, 2024: Neurological Sciences
#3
REVIEW
Abdullah Nadeem, Tasmiyah Siddiqui, Taruba Rais, Rabbia Munsab, Ashna Habib, Eesha Khan Afridi, Fariha Shariq
INTRODUCTION: Acute subdural hematomas (SDH) pose a significant health risk, often resulting from traumatic head injuries. The choice between surgical interventions, craniotomy, and decompressive craniectomy, remains a subject of debate. This meta-analysis aims to compare outcomes and guide clinical decision-making. METHODS: Following PRISMA guidelines, a comprehensive literature search was conducted in databases such as Ovid Medline, PubMed, and Cochrane, up to December 2023...
July 2024: World neurosurgery: X
#4
JOURNAL ARTICLE
H E Hinson, Hannah Radabaugh, Nincheng Li, Toshinori Fukuda, Jeffrey M Pollock, Martin Schreiber, Susan Rowell, Adam R Ferguson
Progression of intracranial hemorrhage is a common, potentially devastating complication after moderate/severe traumatic brain injury (TBI). Clinicians have few tools to predict which patients with traumatic intracranial hemorrhage on their initial head computed tomographic scan (hCT) scan will progress. The objective of this investigation was to identify clinical, imaging, and/or protein biomarkers associated with progression of intracranial hemorrhage (PICH) after moderate/severe TBI and to create an accurate predictive model of PICH based on clinical features available at presentation...
April 15, 2024: Journal of Neurotrauma
#5
JOURNAL ARTICLE
Asanthi M Ratnasekera, Sirivan S Seng, Daniel Kim, Wenyan Ji, Christina L Jacovides, Elinore J Kaufman, Hannah M Sadek, Lindsey L Perea, Christina Monaco Poloni, Ilya Shnaydman, Alexandra Jeongyoon Lee, Victoria Sharp, Angela Miciura, Eric Trevizo, Martin G Rosenthal, Lawrence Lottenberg, William Zhao, Alicia Keininger, Michele Hunt, John Cull, Chassidy Balentine, Tanya Egodage, Aleem T Mohamed, Michelle Kincaid, Stephanie Doris, Robert Cotterman, Sara Seegert, Lewis E Jacobson, Jamie Williams, Melissa Moncrief, Brandi Palmer, Caleb Mentzer, Nichole Tackett, Tjasa Hranjec, Thomas Dougherty, Shawna Morrissey, Lauren Donatelli-Seyler, Amy Rushing, Leah C Tatebe, Tiffany J Nevill, Michel B Aboutanos, David Hamilton, Diane Redmond, Daniel C Cullinane, Carolyne Falank, Mark McMellen, Chris Duran, Jennifer Daniels, Shana Ballow, Kevin M Schuster, Paula Ferrada
BACKGROUND: In patients with severe traumatic brain injury (TBI), clinicians must balance preventing venous thromboembolism (VTE) with the risk of intracranial hemorrhagic expansion (ICHE). We hypothesized that low molecular weight heparin (LMWH) would not increase risk of ICHE or VTE as compared to unfractionated heparin (UH) in patients with severe TBI. METHODS: Patients ≥ 18 years of age with isolated severe TBI (AIS ≥ 3), admitted to 24 level I and II trauma centers between January 1, 2014 to December 31, 2020 and who received subcutaneous UH and LMWH injections for chemical venous thromboembolism prophylaxis (VTEP) were included...
April 9, 2024: Injury
#6
JOURNAL ARTICLE
Catherine B Fortier, Alexandra Kenna, Dylan Katz, Sahra Kim, Colleen Hursh, Brigitta Beck, Caroline A Sablone, Alyssa Currao, Adam Lebas, Ricardo E Jorge, Jennifer R Fonda
BACKGROUND: Many post-9/11 U.S. combat Veterans experience difficulty readjusting to civilian life after military service, including relationship problems, reduced work productivity, substance misuse, and increased anger control problems. Mental health problems are frequently cited as causing these difficulties, driven by unparalleled rates of mild traumatic brain injury, posttraumatic stress, and other co-occurring emotional and physical conditions. Given the high prevalence of multimorbidity in this cohort, acceptable, non-stigmatizing, transdiagnostic interventions targeting reintegration are needed...
April 11, 2024: Contemporary Clinical Trials
#7
REVIEW
Kenya Kawakita, Hajime Shishido, Yasuhiro Kuroda
Therapeutic hypothermia (TH) for severe traumatic brain injury has seen restricted application due to the outcomes of randomized controlled trials (RCTs) conducted since 2000. In contrast with earlier RCTs, recent trials have implemented active normothermia management in control groups, ensuring comparable intensities of non-temperature-related therapeutic interventions, such as neurointensive care. This change in approach may be a contributing factor to the inability to establish the efficacy of TH. Currently, an active temperature management method using temperature control devices is termed "targeted temperature management (TTM)"...
April 8, 2024: Journal of Clinical Medicine
#8
JOURNAL ARTICLE
Hemang Doshi, Kush Deshpande
BACKGROUND: Fever has been shown to be associated with poor outcomes in patients with traumatic brain injury. Earlier studies have used peak daily temperature to derive the burden of fever. The association between hospital mortality and fever burden calculated as the area under the temperature-time curve for the entire duration of intensive care unit (ICU) stay has not been studied before. OBJECTIVES: The objective of this study was to investigate the association between the burden of fever and hospital mortality in patients with isolated traumatic brain injury admitted to the ICU...
April 10, 2024: Australian Critical Care: Official Journal of the Confederation of Australian Critical Care Nurses
#9
JOURNAL ARTICLE
Molly J Sullan, Adam R Kinney, Kelly A Stearns-Yoder, Daniel J Reis, Emerald G Saldyt, Jeri E Forster, Chelsea M Cogan, Nazanin H Bahraini, Lisa A Brenner
BACKGROUND: Individuals with a history of moderate-severe traumatic brain injury (TBI) experience a significantly higher prevalence of insomnia compared to the general population. While individuals living with TBI have been shown to benefit from traditional insomnia interventions (e.g., face-to-face [F2F]), such as Cognitive Behavioral Therapy for Insomnia (CBTI), many barriers exist that limit access to F2F evidence-based treatments. Although computerized CBT-I (CCBT-I) is efficacious in terms of reducing insomnia symptoms, individuals with moderate-severe TBI may require support to engage in such treatment...
April 9, 2024: Contemporary Clinical Trials
#10
JOURNAL ARTICLE
Andrée-Anne Ledoux, Roger Zemek, Molly Cairncross, Noah Silverberg, Veronik Sicard, Nicholas Barrowman, Gary Goldfield, Clare Gray, Ashley D Harris, Natalia Jaworska, Nick Reed, Bechara J Saab, Andra Smith, Lisa Walker
BACKGROUND: Concussion in children and adolescents is a significant public health concern, with 30% to 35% of patients at risk for prolonged emotional, cognitive, sleep, or physical symptoms. These symptoms negatively impact a child's quality of life while interfering with their participation in important neurodevelopmental activities such as schoolwork, socializing, and sports. Early psychological intervention following a concussion may improve the ability to regulate emotions and adapt to postinjury symptoms, resulting in the greater acceptance of change; reduced stress; and recovery of somatic, emotional, and cognitive symptoms...
April 11, 2024: JMIR Research Protocols
#11
RANDOMIZED CONTROLLED TRIAL
Victoriia B Misiura, Larysa A Ruban, Oleksii H Honcharov, Pavlo B Yefimenko, Andriy V Litovchenko
OBJECTIVE: Aim: To study the results of the quality of life, the state of vestibular disorders and the nature of walking of amateur athletes with the consequences of a combat craniocerebral injury after rehabilitation treatment according to a correctional program. PATIENTS AND METHODS: Materials and Methods: The study was conducted on the basis of the Ukrainian Scientific Research Institute of Prosthetics in Kharkov. Under observation were 38 men aged 25-42 years with long-term consequences of a closed craniocerebral injury in the late long-term period...
2024: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
#12
JOURNAL ARTICLE
Kevin K W Wang, David J Barton, Leah McQuillan, Firas Kobeissy, Guangzheng Cai, Haiyan Xu, Zhihui Yang, Erin Trifilio, John B Williamson, Richard Rubenstein, Claudia S Robertson, Amy K Wagner
Neurofilament-light chain (NF-L) and phosphorylated neurofilament-heavy chain (pNF-H) are axonal proteins that have been reported as potential diagnostic and prognostic biomarkers in traumatic brain injury (TBI). However, detailed temporal profiles for these proteins in blood, and interrelationships in the acute and chronic time periods post-TBI have not been established. Our objectives were 1) to characterize acute-to-chronic serum NF-L and pNF-H profiles after moderate-severe TBI, as well as acute cerebrospinal fluid (CSF) levels, 2) to evaluate CSF and serum NF-L and pNF-H associations with each other, and 3) to assess biomarker associations with global patient outcome using both the Glasgow Outcome Scale-Extended (GOS-E) and Disability Rating Scale (DRS)...
April 8, 2024: Journal of Neurotrauma
#13
JOURNAL ARTICLE
Matthew Pease, Adi Mittal, Sara Merkaj, David O Okonkwo, Jorge A Gonzalez-Martinez, Jonathan Elmer, Wen-Shyong Liou, Valeria Pingue, Flora M Hammond, Sergiu Abramovici, James Castellano, Niravkumar Barot
IMPORTANCE: Guidelines recommend seizure prophylaxis for early posttraumatic seizures (PTS) after severe traumatic brain injury (TBI). Use of antiseizure medications for early seizure prophylaxis after mild or moderate TBI remains controversial. OBJECTIVE: To determine the association between seizure prophylaxis and risk reduction for early PTS in mild and moderate TBI. DATA SOURCES: PubMed, Google Scholar, and Web of Science (January 1, 1991, to April 18, 2023) were systematically searched...
April 8, 2024: JAMA Neurology
#14
JOURNAL ARTICLE
D Bark, M Boman, B Depreitere, D W Wright, A Lewén, P Enblad, A Hånell, E Rostami
Outcome after traumatic brain injury (TBI) is typically assessed using the Glasgow outcome scale extended (GOSE) with levels from 1 (death) to 8 (upper good recovery). Outcome prediction has classically been dichotomized into either dead/alive or favorable/unfavorable outcome. Binary outcome prediction models limit the possibility of detecting subtle yet significant improvements. We set out to explore different machine learning methods with the purpose of mapping their predictions to the full 8 grade scale GOSE following TBI...
April 5, 2024: Scientific Reports
#15
JOURNAL ARTICLE
Armin Karamian, Hana Farzaneh, Mojtaba Taheri, Ali Seifi
OBJECTIVE: Traumatic brain injury (TBI) and the subsequent Post-traumatic seizure (PTS) is a growing public health concern. Generally, anti-seizure drugs (ASDs) are recommended for PTS prophylaxis and treatment. This meta-analysis aimed to review the current state of knowledge and the evidence for the efficacy and safety of Levetiracetam (LEV) on the incidence of seizure in TBI patients compared to Phenytoin (PHT). METHODS: A search was carried out based on PubMed, MEDLINE, Europe PMC database, and Cochrane Library up to November 2023...
March 20, 2024: Clinical Neurology and Neurosurgery
#16
Keisuke Kawata, Devin J Rettke, Christopher Thompson, Rebekah Mannix, Jeffrey J Bazarian, Dibyadyuti Datta
Traumatic brain injury (TBI), in any form and severity, can pose risks for developing chronic symptoms that can profoundly hinder patients' work/academic, social, and personal lives. In the past 3 decades, a multitude of pharmacological, stimulation, and exercise-based interventions have been proposed to ameliorate symptoms, memory impairment, mental fatigue, and/or sleep disturbances. However, most research is preliminary, thus limited influence on clinical practice. This review aims to systematically appraise the evidence derived from randomized controlled trials (RCT) regarding the effectiveness of pharmacological, stimulation, and exercise-based interventions in treating chronic symptoms due to TBI...
2024: Frontiers in Neurology
#17
Masato Mitsuhashi, Akihiro Hirata, Yuko Oguma, Hiroyuki Ishida, Keisuke Kawata
The myelin sheath surrounding axons is vulnerable to mechanical stresses after head injuries, as well as autoimmune attacks and degeneration in neurological disorders. Unfortunately, there is currently no effective method to assess these axonal conditions in individual patients. We have developed a sandwich immunoassay detecting dual signals of myelin oligodendrocyte glycoprotein (MOG) and interleukin 1B (IL1B) in human plasma ([IL1B on MOG]). While IL1B is one of common inflammation markers, its lack of tissue specificity is addressed by identifying IL1B on extracellular vesicles from oligodendrocytes isolated using anti-MOG, suggesting inflammation around axons...
March 13, 2024: Research Square
#18
JOURNAL ARTICLE
Shaurya Taran, Bastien Perrot, Federico Angriman, Raphael Cinotti
OBJECTIVES: To evaluate the association between the pre-extubation sum of eye and motor components of the Glasgow Coma Score (GCS-EM) and odds of extubation failure in patients with acute brain injury being liberated from mechanical ventilation. DESIGN: Secondary analysis of a prospective, multicenter observational study (ClinicalTrials.gov identifier NCT03400904). SETTING: Sixty-three hospital sites worldwide, with patient recruitment from January 2018 to November 2020...
April 1, 2024: Critical Care Medicine
#19
JOURNAL ARTICLE
Kavita Kaushik, Nidhi Sharma, Parveen Kumar, Simranjeet Kaur, Gaurav Kapoor, Ajay Gehlot
OBJECTIVES: The study aimed to compare the effect of cranial electrical stimulation (CES) and transcranial direct current stimulation (tDCS) in improving cognition among individuals with mild traumatic brain injury. PATIENTS AND METHODS: The pretest-posttest randomized controlled study was conducted between November 2020 and March 2022. Seventy-two patients (64 males, 8 females; mean age: 40.5±9.5 years; range, 18 to 45 years) experiencing cognitive impairment within three months of traumatic brain injury were recruited...
March 2024: Turkish journal of physical medicine and rehabilitation
#20
JOURNAL ARTICLE
Tingting An, Zibei Dong, Xiangyang Li, Yifan Ma, Jie Jin, Liqing Li, Lanjuan Xu
BACKGROUND: Both the International Mission for Prognosis and Analysis of Clinical Trials (IMPACT) and the Corticosteroid randomization after significant head injury (CRASH) models are globally acknowledged prognostic algorithms for assessing traumatic brain injury (TBI) outcomes. The aim of this study is to externalize the validation process and juxtapose the prognostic accuracy of the CRASH and IMPACT models in moderate-to-severe TBI patients in the Chinese population. METHODS: We conducted a retrospective study encompassing a cohort of 340 adult TBI patients (aged > 18 years), presenting with Glasgow Coma Scale (GCS) scores ranging from 3 to 12...
January 1, 2024: Translational Neuroscience
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