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Traumatic brain injury randomized

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https://www.readbyqxmd.com/read/27919428/anxiety-and-comorbid-depression-following-traumatic-brain-injury-in-a-community-based-sample-of-young-middle-aged-and-older-adults
#1
A J Osborn, J L Mathias, A K Fairweather-Schmidt, K J Anstey
BACKGROUND: Anxiety is common following a traumatic brain injury (TBI), but who is most at risk, and to what extent, is not well understood. METHODS: Longitudinal data from a randomly-selected community sample (Wave 1: 7397, Wave 2: 6621 and Wave 3: 6042) comprising three adult cohorts (young: 20-24 years of age, middle-aged: 40-44, older: 60-64), were analysed. The association between TBI history, anxiety and comorbid depression was assessed, controlling for age, sex, marital/employment status, medical conditions, recent life events, alcohol consumption, social support and physical activity...
October 5, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27913796/a-randomized-controlled-trial-of-assisted-intention-monitoring-for-the-rehabilitation-of-executive-impairments-following-acquired-brain-injury
#2
Fergus Gracey, Jessica E Fish, Eve Greenfield, Andrew Bateman, Donna Malley, Gemma Hardy, Jessica Ingham, Jonathan J Evans, Tom Manly
BACKGROUND: Acquired brain injury (ABI) can impair executive function, impeding planning and attainment of intentions. Research shows promise for some goal-management rehabilitation interventions. However, evidence that alerts assist monitoring and completion of day-to-day intentions is limited. OBJECTIVE: To examine the efficacy of brief goal-directed rehabilitation paired with periodic SMS text messages designed to enhance executive monitoring of intentions (assisted intention monitoring [AIM])...
December 2, 2016: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/27911325/autonomic-nervous-system-dysfunctions-as-a-basis-for-a-predictive-model-of-risk-of%C3%A2-neurological-disorders-in-subjects-with%C3%A2-prior-history-of-traumatic-brain-injury-implications-in-alzheimer-s-disease
#3
Lap Ho, Marc Legere, Tongbin Li, Samara Levine, Ke Hao, Breanna Valcarcel, Giulio M Pasinetti
Autonomic dysfunction is very common in patients with dementia, and its presence might also help in differential diagnosis among dementia subtypes. Various central nervous system structures affected in Alzheimer's disease (AD) are also implicated in the central autonomic nervous system (ANS) regulation. For example, deficits in central cholinergic function in AD could likely lead to autonomic dysfunction. We recently developed a simple, readily applicable evaluation for monitoring ANS disturbances in response to traumatic brain injury (TBI)...
December 1, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27910267/the-impact-of-patient-characteristics-on-nurse-practitioners-assessment-and-management-of-adolescent-concussion
#4
Janessa M Graves, Tracy A Klein
BACKGROUND AND PURPOSE: To evaluate the effect of patient sex and type of activity on concussion assessment and management recommendations. METHODS: We administered a web-based survey to all nurse practitioners (NPs) actively licensed in Washington and Oregon. Participants were randomized to view one of four standardized patient scenario videos of an adolescent seeking care for a concussion, portraying the same symptomology but differing by sex and activity (soccer/hiking)...
December 2, 2016: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/27907969/neuroprotection-in-critical-care-neurology
#5
Menno R Germans, Hieronymus D Boogaarts, R Loch Macdonald
Ischemic stroke, intracerebral hemorrhage, subarachnoid hemorrhage, and traumatic brain injury-all have in common early brain injury due to brain tissue destruction, reduced cerebral blood flow and oxygen delivery, and overall substantial morbidity and mortality. The pathophysiology of brain tissue damage likely includes common cellular mechanisms. Neuroprotection has seldom, if ever, been shown to reduce early brain injury. Secondary brain injury develops after these conditions due to macroscopic events such as increased intracranial pressure and reduced cerebral blood flow, as well as cellular processes including vascular damage, inflammation, and apoptotic/necrotic cell death...
December 2016: Seminars in Neurology
https://www.readbyqxmd.com/read/27904759/a-review-of-sub-acute-subdural-hematoma-sasdh-with-our-institutional-experience-and-its-management-by-double-barrel-technique-dbt-a-novel-technique
#6
Soubhagya R Tripathy, Pankaj K Swarnakar, Sanjib Mishra, Sudhanshu S Mishra, Manmath K Dhir, Sanjay K Behera, Pratap C Nath, Somnath P Jena, Itibrata Mohanta, Deepak Das, Mani C Satapathy, Sitansu K Rout, Bikash R Behera, Deepak K Parida, Tanushree S Rath
BACKGROUND: Subacute subdural hematoma (SASDH) is an entity which is yet to capture the popular imagination among the neurosurgeons. Its management is often equated clinically to that of the chronic subdural hematoma (CSDH). However, their neurological deterioration is usually rapid, which seems to align them with acute subdural hematoma (ASDH). We proceed for their epidemiological evaluation. The advantages of a novel "double barrel technique (DbT)" over the conventional burrhole drainage are also presented...
2016: Surgical Neurology International
https://www.readbyqxmd.com/read/27893618/early-resuscitation-with-lyophilized-plasma-provides-equal-neuroprotection-compared-with-fresh-frozen-plasma-in-a-large-animal-survival-model-of-traumatic-brain-injury-and-hemorrhagic-shock
#7
Ihab Halaweish, Ted Bambakidis, Vahagn C Nikolian, Patrick Georgoff, Peter Bruhn, Patryk Piascik, Lisa Buckley, Ashok Srinivasan, Baoling Liu, Yongqing Li, Hasan B Alam
BACKGROUND: Combined traumatic brain injury (TBI) and hemorrhagic shock (HS) is highly lethal. In previous models of combined TBI + HS, we showed that early resuscitation with fresh frozen plasma (FFP) improves neurologic outcomes. Delivering FFP, however, in austere environments is difficult. Lyophilized plasma (LP) is a logistically superior alternative to FFP, but data are limited regarding its efficacy for treatment of TBI. We conducted this study to determine the safety and long-term outcomes of early treatment with LP in a large animal model of TBI + HS...
December 2016: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/27891355/the-effect-of-continuous-enteral-nutrition-on-nutrition-indices-compared-to-the-intermittent-and-combination-enteral-nutrition-in-traumatic-brain-injury-patients
#8
Sakine Mazaherpur, Alireza Khatony, Alireza Abdi, Yahia Pasdar, Farid Najafi
INTRODUCTION: Nutrition support is one of the most common care, which is undertaken for patients who suffered from Traumatic Brain Injury (TBI) and are admitted in intensive care units. Literature indicates some controversies regarding the appropriate method of nutrition support in these patients. AIM: This study was conducted for determining the effect of continuous enteral nutrition on nutrition indices, compared to the intermittent enteral and combination nutrition in TBI patients...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27874023/methylphenidate-and-memory-and-attention-adaptation-training-for-persistent-cognitive-symptoms-after-traumatic-brain-injury-a-randomized-placebo-controlled-trial
#9
Brenna C McDonald, Laura A Flashman, David B Arciniegas, Robert J Ferguson, Li Xing, Jaroslaw Harezlak, Gwen C Sprehn, Flora M Hammond, Arthur C Maerlender, Carrie L Kruck, Karen L Gillock, Kim Frey, Rachel N Wall, Andrew J Saykin, Thomas W McAllister
The purpose of this multicenter, prospective, randomized, placebo-controlled study was to evaluate and compare the efficacy of two cognitive rehabilitation interventions (Memory and Attention Adaptation Training (MAAT) and Attention Builders Training (ABT)), with and without pharmacologic enhancement (ie, with methylphenidate (MPH) or placebo), for treating persistent cognitive problems after traumatic brain injury (TBI). Adults with a history of TBI at least four months prior to study enrollment with either objective cognitive deficits or subjective cognitive complaints were randomized to receive MPH or placebo and MAAT or ABT, yielding four treatment combinations: MAAT/MPH (N=17), ABT/MPH (N=19), MAAT/placebo (N=17), and ABT/placebo (N=18)...
November 22, 2016: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27868069/early-inflammatory-response-following-traumatic-brain-injury-in-rabbits-using-uspio-and-gd-enhanced-mri
#10
Lin Ouyang, Si Zeng, Gang Zheng, Guang Ming Lu
Purpose. To monitor the inflammatory response (IR) following traumatic brain injury (TBI) before and after the rehabilitation of the blood-brain barrier (BBB) in rabbits using USPIO- and Gd-enhanced MRI. Materials and Methods. Twenty white big-eared rabbits with mild TBI (mTBI) were randomly and equally divided into four groups. Rabbits were sacrificed for the brain specimens immediately after the last MRI-monitoring. Sequences were tse-T1WI, tse-T2WI, Gd-T1WI, and USPIO-T1WI. Dynamical MRI presentations were evaluated and compared with pathological findings for each group...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27865153/efficient-multi-scale-3d-cnn-with-fully-connected-crf-for-accurate-brain-lesion-segmentation
#11
Konstantinos Kamnitsas, Christian Ledig, Virginia F J Newcombe, Joanna P Simpson, Andrew D Kane, David K Menon, Daniel Rueckert, Ben Glocker
We propose a dual pathway, 11-layers deep, three-dimensional Convolutional Neural Network for the challenging task of brain lesion segmentation. The devised architecture is the result of an in-depth analysis of the limitations of current networks proposed for similar applications. To overcome the computational burden of processing 3D medical scans, we have devised an efficient and effective dense training scheme which joins the processing of adjacent image patches into one pass through the network while automatically adapting to the inherent class imbalance present in the data...
October 29, 2016: Medical Image Analysis
https://www.readbyqxmd.com/read/27859797/in-vitro-and-in-vivo-effects-of-a-novel-dimeric-inhibitor-of-psd-95-on-excitotoxicity-and-functional-recovery-after-experimental-traumatic-brain-injury
#12
Jens Bak Sommer, Anders Bach, Hana Malá, Kristian Strømgaard, Jesper Mogensen, Darryl Scott Pickering
PSD-95 inhibitors have been shown to be neuroprotective in stroke, but have only to a very limited extent been evaluated in the treatment of traumatic brain injury (TBI) that has pathophysiological mechanisms in common with stroke. The aims of the current study were to assess the effects of a novel dimeric inhibitor of PSD-95, UCCB01-147, on histopathology and long-term cognitive outcome after controlled cortical impact (CCI) in rats. As excitotoxic cell death is thought to be a prominent part of the pathophysiology of TBI, we also investigated the neuroprotective effects of UCCB01-147 and related compounds on NMDA-induced cell death in cultured cortical neurons...
November 17, 2016: European Journal of Neuroscience
https://www.readbyqxmd.com/read/27855720/pharmacological-interventions-for-agitation-in-patients-with-traumatic-brain-injury-protocol-for-a-systematic-review-and-meta-analysis
#13
David R Williamson, Anne Julie Frenette, Lisa Burry, Marc M Perreault, Emmanuel Charbonney, François Lamontagne, Marie-Julie Potvin, Jean-François Giguère, Sangeeta Mehta, Francis Bernard
BACKGROUND: Traumatic brain injury (TBI) is a worldwide leading cause of mortality and disability. Among TBI complications, agitation is a frequent behavioural problem. Agitation causes potential harm to patients and caregivers, interferes with treatments, leads to unnecessary chemical and physical restraints, increases hospital length of stay, delays rehabilitation, and impedes functional independence. Pharmacological treatments are often considered for agitation management following TBI...
November 17, 2016: Systematic Reviews
https://www.readbyqxmd.com/read/27852302/early-electroacupuncture-treatment-ameliorates-neuroinflammation-in-rats-with-traumatic-brain-injury
#14
Wei-Chen Tang, Yao-Chin Hsu, Che-Chuan Wang, Chiao-Ya Hu, Chung-Ching Chio, Jinn-Rung Kuo
BACKGROUND: Neuroinflammation is the leading cause of neurological sequelae after traumatic brain injury (TBI). The aim of the present study was to investigate whether the neuroprotective effects of electroacupuncture (EA) are mediated by anti-neuroinflammatory effects in a rat model of TBI. METHODS: Male Sprague-Dawley rats were randomly divided into three groups: sham-operated, TBI control, and EA-treated. The animals in the sham-operated group underwent a sham operation, those in the TBI control group were subjected to TBI, but not EA, and those in the EA group were treated with EA for 60 min immediately after TBI, daily for 3 consecutive days...
November 16, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27834541/supervised-learning-technique-for-the-automated-identification-of-white-matter-hyperintensities-in-traumatic-brain-injury
#15
James R Stone, Elisabeth A Wilde, Brian A Taylor, David F Tate, Harvey Levin, Erin D Bigler, Randall S Scheibel, Mary R Newsome, Andrew R Mayer, Tracy Abildskov, Garrett M Black, Michael J Lennon, Gerald E York, Rajan Agarwal, Jorge DeVillasante, John L Ritter, Peter B Walker, Stephen T Ahlers, Nicholas J Tustison
BACKGROUND: White matter hyperintensities (WMHs) are foci of abnormal signal intensity in white matter regions seen with magnetic resonance imaging (MRI). WMHs are associated with normal ageing and have shown prognostic value in neurological conditions such as traumatic brain injury (TBI). The impracticality of manually quantifying these lesions limits their clinical utility and motivates the utilization of machine learning techniques for automated segmentation workflows. METHODS: This study develops a concatenated random forest framework with image features for segmenting WMHs in a TBI cohort...
2016: Brain Injury: [BI]
https://www.readbyqxmd.com/read/27834471/efficacy-and-safety-of-botulinum-toxin-type-a-for-upper-limb-spasticity-after-stroke-or-traumatic-brain-injury-a-systematic-review-with-meta-analysis-and-trial-sequential-analysis
#16
Yan Dong, Tao Wu, Xiaohua Hu, Tong Wang
INTRODUCTION: Muscle spasticity is a positive symptom after stroke and traumatic brain injury. Botulinum Toxin type A injection is widely used for treating post stroke and traumatic brain injury spasticity. This study aimed to evaluate efficacy and safety of Botulinum Toxin type A for upper limb spasticity after stroke and traumatic brain injury and investigate reliability and conclusiveness of available evidence for Botulinum Toxin type A intervention. EVIDENCE ACQUISITION: We searched electronic databases from inception to September 10 of 2016...
November 11, 2016: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27833541/cognitive-training-for-post-acute-traumatic-brain-injury-a-systematic-review-and-meta-analysis
#17
Harry Hallock, Daniel Collins, Amit Lampit, Kiran Deol, Jennifer Fleming, Michael Valenzuela
Objective: To quantitatively aggregate effects of cognitive training (CT) on cognitive and functional outcome measures in patients with traumatic brain injury (TBI) more than 12-months post-injury. Design: We systematically searched six databases for non-randomized and randomized controlled trials of CT in TBI patients at least 12-months post-injury reporting cognitive and/or functional outcomes. Main Measures: Efficacy was measured as standardized mean difference (Hedges' g) of post-training change. We investigated heterogeneity across studies using subgroup analyses and meta-regressions...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27831729/a-randomized-problem-solving-trial-for-adolescent-brain-injury-changes-in-social-competence
#18
Sarah J Tlustos, Michael W Kirkwood, H Gerry Taylor, Terry Stancin, Tanya M Brown, Shari L Wade
PURPOSE/OBJECTIVE: Traumatic brain injury (TBI) in adolescence has well documented effects on social competence. Few studies have examined the effects of behavioral interventions on social competence or identified factors associated with changes in social competence after injury. Research Method/Design: Adolescents with moderate to severe TBI ages 12-17 years were randomized within 6 months of injury to either a problem solving and communication (CAPS) group that received online counseling (n = 65) or an Internet resources comparison (IRC) group (n = 67) for a comparative effectiveness trial...
November 2016: Rehabilitation Psychology
https://www.readbyqxmd.com/read/27829310/traumatic-brain-injury-and-alcohol-substance-abuse-a-bayesian-meta-analysis-comparing-the-outcomes-of-people-with-and-without-a-history-of-abuse
#19
David J Unsworth, Jane L Mathias
Alcohol and substance (drugs and/or alcohol) abuse are major risk factors for traumatic brain injury (TBI); however, it remains unclear whether outcomes differ for those with and without a history of preinjury abuse. A meta-analysis was performed to examine this issue. The PubMed, Embase, and PsycINFO databases were searched for research that compared the neuroradiological, cognitive, or psychological outcomes of adults with and without a documented history of alcohol and/or substance abuse who sustained nonpenetrating TBIs...
November 10, 2016: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/27821129/traumatic-brain-injury-patient-volume-and-mortality-in-neurosurgical-intensive-care-units-a-finnish-nationwide-study
#20
Rahul Raj, Stepani Bendel, Matti Reinikainen, Sanna Hoppu, Teemu Luoto, Tero Ala-Kokko, Sami Tetri, Ruut Laitio, Timo Koivisto, Jaakko Rinne, Riku Kivisaari, Jari Siironen, Markus B Skrifvars
BACKGROUND: Differences in outcomes after traumatic brain injury (TBI) between neurosurgical centers exist, although the reasons for this are not clear. Thus, our aim was to assess the association between the annual volume of TBI patients and mortality in neurosurgical intensive care units (NICUs). METHODS: We collected data on all patients treated in the five Finnish university hospitals to examine all patients with TBI treated in NICUs in Finland from 2009 to 2012...
November 8, 2016: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
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