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Brimonidine

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https://www.readbyqxmd.com/read/29310481/nanostructured-lipid-carriers-for-intraocular-brimonidine-localization-development-in-vitro-and-in-vivo-evaluation
#1
Noha S El-Salamouni, Ragwa M Farid, Amal H El-Kamel, Safaa S El-Gamal
Brimonidine ocular hypotensive effect can be enhanced by increasing residence time and corneal penetration. The current work aimed to formulate, evaluate and compare nanostructured lipid carriers (NLCs) to solid lipid nanoparticles (SLNs) and commercial eye drops for controlled brimonidine delivery. NLCs prepared by modified high shear homogenization were spherical with a mean size of 151.97 ±1.98 nm, negative zeta potential (ZP) of -44.2± 7.81 mV, % entrapment efficiency (EE) of 83.631 ±0.495% and low crystallinity index (CI) (17...
January 9, 2018: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29297751/the-efficacy-and-safety-of-the-fixed-combination-of-brinzolamide-1-and-brimonidine-0-2-in-normal-tension-glaucoma-an-18-month-retrospective-study
#2
Sang Wook Jin, Sae Mi Lee
PURPOSE: To evaluate efficacy and safety of brinzolamide (1%)/brimonidine (0.2%) fixed combination (BBFC) in normal tension glaucoma (NTG). METHODS: This retrospective study included NTG patients treated with BBFC as their primary therapy, NTG patients who had changed their medication to BBFC from brinzolamide or brimonidine, and NTG patients who had changed their medication to BBFC from concomitantly using brinzolamide and brimonidine. The intraocular pressure (IOP), mean deviation value, and adverse drug reactions were evaluated...
January 3, 2018: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29228819/formulation-and-ex-vivo-in-vivo-evaluation-of-ph-triggered-brimonidine-tartrate-in-situ-gel-for-the-glaucoma-treatment-using-application-of-32-factorial-design
#3
Rohan K Barse, Amol A Tagalpallewar, Chandrakant R Kokare, Jaya P Sharma, Pankaj K Sharma
CONTEXT: Short residence time, poor bioavailability and poor permeability are the major problems for conventional eye drops treatment. OBJECTIVE: The aim of this article is to develop, optimize and ex vivo-in vivo investigation of brimonidine tartrate in situ gel as compare to marketed eye drops for the treatment of glaucoma. MATERIALS AND METHODS: The effect of independent variables viz. concentrations of polymers, on various dependent variables like viscosity at physiological pH and in vitro drug release were studied by using 32 factorial design...
December 12, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29204068/%C3%AE-adrenergic-agonist-brimonidine-control-of-experimentally-induced-myopia-in-guinea-pigs-a-pilot-study
#4
Yan Liu, Yuexin Wang, Huibin Lv, Xiaodan Jiang, Mingzhou Zhang, Xuemin Li
Purpose: To investigate the efficacy of α-adrenergic agonist brimonidine either alone or combined with pirenzepine for inhibiting progressing myopia in guinea pig lens-myopia-induced models. Methods: Thirty-six guinea pigs were randomly divided into six groups: Group A received 2% pirenzepine, Group B received 0.2% brimonidine, Group C received 0.1% brimonidine, Group D received 2% pirenzepine + 0.2% brimonidine, Group E received 2% pirenzepine + 0.1% brimonidine, and Group F received the medium...
2017: Molecular Vision
https://www.readbyqxmd.com/read/29164631/effects-of-selective-%C3%AE-2-adrenergic-receptor-agonists-on-electrical-field-stimulated-contractions-of-isolated-bronchi-in-horses
#5
A Menozzi, C Pozzoli, E Poli, C Colla, G Placenza, S Bertini
We investigated the effects of different selective α2 -adrenergic receptor (AR) agonists (detomidine, medetomidine, xylazine, and brimonidine) on the contractions of horse-isolated bronchi induced by electrical field stimulation (EFS) and by carbachol. No effects were observed on the contraction induced by carbachol, while α2 -AR agonists reduced EFS-evoked contractions in a concentration-related fashion. The rank order of potency (pD2 ) was brimonidine (7.40 ± 0.20) >medetomidine (7.09 ± 0.24) >detomidine (6...
November 21, 2017: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29159432/comparison-of-the-neuroprotective-effects-of-brimonidine-tartrate-and-melatonin-on-retinal-ganglion-cells
#6
Deniz Marangoz, Elif Guzel, Signem Eyuboglu, Asli Gumusel, Ismail Seckin, Ferda Ciftci, Bayram Yilmaz, Ilgaz Yalvac
PURPOSE: We aimed to compare the neuroprotective effects of brimonidine tartrate (BRT) and melatonin (MEL) on retinal ganglion cells (RGCs) in a rat glaucoma model. METHODS: Thirty-six adult Wistar albino rats were allocated into six groups: control (C), glaucoma (G), BRT, MEL, G + BRT and G + MEL. After establishing the glaucoma model, intraocular pressure (IOP) of all animals measured at day 4 and day 30 was compared statistically with day 0 and day 4, respectively...
November 20, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/29152562/fast-dissolving-dendrimer-nanofiber-mats-as-alternative-to-eye-drops-for-more-efficient-antiglaucoma-drug-delivery
#7
Michael G Lancina, Sudha Singh, Uday B Kompella, Shahid Husain, Hu Yang
Polyamidoamine (PAMAM) dendrimers have been investigated as a potential platform for a number of ocular drugs, but only in aqueous solution. In this work we have developed fast dissolving dendrimer-based nanofibers (DNF) as a topical delivery vehicle for the glaucoma drug brimonidine tartrate (BT). The safety and drug release kinetics of these nanofiber mats were evaluated in vitro and in vivo. DNF caused no toxicity at therapeutic levels in cultured cells or ocular irritation in animal tests using a normotensive rat model...
August 14, 2017: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/29151684/glaucoma-medication-preferences-among-glaucoma-specialists-in-mexico
#8
Gabriel Lazcano-Gomez, Daniela Alvarez-Ascencio, Cindy Haro-Zuno, Mauricio Turati-Acosta, Magdalena Garcia-Huerta, Jesus Jimenez-Arroyo, Rafael Castañeda-Diez, Armando Castillejos-Chevez, Roberto Gonzalez-Salinas, Francisca Dominguez-Dueñas, Jesus Jimenez-Roman
Aim: To determine the glaucoma specialists' preferences for the different brands of topical glaucoma medications available in Mexico. Materials and methods: A web-based survey was sent to 150 board-certified glaucoma specialists in Mexico, with 14 questions related to brand preferences for all glaucoma medications available in Mexico. Participants were asked to select each glaucoma medication class by brand and to state the factors leading to their choice. Results: Data from 111 (74%) glaucoma specialists were collected...
September 2017: Journal of Current Glaucoma Practice
https://www.readbyqxmd.com/read/29135708/high-permeability-and-intercellular-space-widening-with-brimonidine-tartrate-eye-drops-in-cultured-stratified-human-corneal-epithelial-sheets
#9
Yumi Hashimoto, Seiichi Yokoo, Tomohiko Usui, Yukiko Tsubota, Satoru Yamagami
PURPOSE: To investigate the toxicity of topical glaucoma medications using cultured stratified human corneal epithelial sheets (HCES). METHODS: HCES were exposed for 30 minutes to the following glaucoma medications: 0.1% brimonidine with sodium chlorite as the preservative, 0.005% latanoprost with 0.02% benzalkonium chloride (BAC) as the preservative, and 0.5% timolol with 0.005% BAC as the preservative. Then, cell viability and barrier function were tested by the WST-1 assay and carboxyfluorescein permeability assay, respectively...
November 13, 2017: Cornea
https://www.readbyqxmd.com/read/29120262/evaluation-of-efficacy-and-safety-of-brimonidine-tartrate-ophthalmic-solution-0-025-for-treatment-of-ocular-redness
#10
Gail L Torkildsen, Christine M Sanfilippo, Heleen H DeCory, Paul J Gomes
Purpose/Aims: This study assessed the efficacy and safety of brimonidine tartrate ophthalmic solution, 0.025% for treating ocular redness in adult subjects. MATERIALS AND METHODS: This was a single-center, double-masked, randomized, vehicle-controlled, parallel-group study in subjects ≥40 years, with ocular redness. Subjects were randomized 2:1 to brimonidine or vehicle, instilled QID for four weeks. Subjects completed four visits, the last occurring one week after treatment discontinuation...
November 9, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29104721/topical-a-agonist-therapy-for-persistent-facial-erythema-of-rosacea-and-the-addition-of-oxmetazoline-to-the-treatment-armamentarium-where-are-we-now
#11
REVIEW
James Q Del Rosso
The presence of vasoactivity in rosacea-affected skin led to the development of two topical α-adrenergic receptor agonists, brimonidine tartrate 0.5% gel and oxymetazoline hydrochloride 1% cream, both approved by the United States Food and Drug Administration for treatment of persistent facial erythema of rosacea. In this article, the author discusses challenges related to the treatment of persistent facial erythema of rosacea and the use of a-agonist therapy. The author also discusses cases of worsening of facial erythema after the application of brimonidine, as well as briefly reviews recently reported clinical data on oxymetazoline...
July 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29094614/role-of-topical-oxymetazoline-for-management-of-erythematotelangiectatic-rosacea
#12
Rebecca M Hoover, John Erramouspe
OBJECTIVE: To review and summarize topical oxymetazoline's pharmacology, pharmacokinetics, efficacy, safety, cost, and place in therapy for persistent redness associated with erythematotelangiectatic rosacea. DATA SOURCES: Literature searches of MEDLINE (1975 to September 2017), International Pharmaceutical Abstracts (1975 to September 2017), and Cochrane Database (publications through September 2017) using the terms rosacea, persistent redness, α -agonist, and oxymetazoline...
November 1, 2017: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29077635/topical-brimonidine-tartrate-0-33-gel-on-postlaser-erythema-our-experience-and-review-of-the-literature
#13
Sang Ju Lee, Hyeree Kim, Hei Sung Kim
No abstract text is available yet for this article.
October 26, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29057117/a-masked-randomized-phase-3-comparison-of-triple-fixed-combination-bimatoprost-brimonidine-timolol-versus-fixed-combination-brimonidine-timolol-for-lowering-intraocular-pressure
#14
Curt Hartleben, Juan Camilo Parra, Amy Batoosingh, Paula Bernstein, Margot Goodkin
OBJECTIVE: To evaluate the efficacy and safety of triple fixed-combination bimatoprost 0.01%/brimonidine 0.15%/timolol 0.5% (TFC) versus dual fixed-combination brimonidine 0.2%/timolol 0.5% (DFC) in primary open-angle glaucoma and ocular hypertension. METHODS: Patients with intraocular pressure (IOP) ≥23 and ≤34 mmHg were randomized to twice-daily TFC or DFC. The primary variable is the change in worse eye mean IOP from baseline at week 12 (modified intent-to-treat (mITT) population)...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29031658/randomized-controlled-pilot-study-of-the-preoperative-use-of-brimonidine-0-33-topical-gel-for-hemostasis-in-mohs-micrographic-surgery
#15
Edward Chen, Raj Ajay Patel, Young Jin Kwak, Conway C Huang
BACKGROUND: Brimonidine topical gel may be useful in cutaneous surgical procedures because of its vasoconstricting properties. OBJECTIVE: Assess the hemostatic effect of topically applied brimonidine in patients being treated with anticoagulants and undergoing Mohs micrographic surgery (MMS). METHODS: Subjects undergoing MMS were randomly assigned to the control (n = 10) or study arm (n = 14). Controls received standard-of-care MMS, whereas the study arm received the same and preoperative application of brimonidine...
December 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29026287/ocular-pharmacokinetics-and-tolerability-of-bimatoprost-ophthalmic-solutions-administered-once-or-twice-daily-in-rabbits-and-clinical-dosing-implications
#16
Jie Shen, Margot L Goodkin, Warren Tong, Mayssa Attar
PURPOSE: Fixed-combination medications can benefit patients requiring multiple agents to lower their intraocular pressure (IOP), but combining agents with complementary mechanisms of action is challenging if their dosing frequency differs. This study compares in vivo pharmacokinetic and ocular tolerability of bimatoprost 0.01% ophthalmic solutions dosed once or twice daily. Reports of twice-daily dosing in glaucoma patients are also reviewed. METHODS: New Zealand White rabbits were administered bimatoprost 0...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28938378/severe-corneal-disorders-developed-after-brimonidine-tartrate-ophthalmic-solution-use
#17
Yuko Maruyama, Yoko Ikeda, Norihiko Yokoi, Kazuhiko Mori, Hiroaki Kato, Morio Ueno, Shigeru Kinoshita, Chie Sotozono
PURPOSE: The primary side effects associated with 0.1% brimonidine tartrate (BT) ophthalmic solution with sodium chlorite are allergic conjunctivitis, blepharitis, and conjunctival hyperemia. However, cornea-related side effects are rare. In this study, we report 2 similar cases in which corneal neovascularization, corneal infiltration, and corneal opacity developed after BT eye-drop use. METHODS: Retrospective report of 2 cases of corneal infiltration after BT eye-drop use...
December 2017: Cornea
https://www.readbyqxmd.com/read/28915286/treatment-of-rosacea-with-concomitant-use-of-topical-ivermectin-1-cream-and-brimonidine-0-33-gel-a-randomized-vehicle-controlled-study
#18
Linda Stein Gold, Kim Papp, Charles Lynde, Edward Lain, Melinda Gooderham, Sandra Johnson, Nabil Kerrouche
BACKGROUND: There is currently a lack of data on the simultaneous treatment of different features of rosacea. Individually, ivermectin 1% (IVM) cream and brimonidine 0.33% (BR) gel have demonstrated efficacy on inflammatory lesions and persistent erythema, respectively. OBJECTIVE: To evaluate the efficacy, safety, patient satisfaction, and optimal timing of administration of IVM associated with BR (IVM+BR) versus their vehicles in rosacea (investigator global assessment [IGA] ≥3)...
September 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28900607/de-novo-intraocular-amyloid-deposition-after-hepatic-transplantation-in-familial-amyloidotic-polyneuropathy
#19
Ivo Filipe Gama, Leonor Duarte Almeida
The familiar amyloid polyneuropathy (FAP) is a rare autosomal-dominant systemic amyloidosis. Amyloid deposition occurs more frequently and extensively in the vitq. The increase in intraocular pressure (IOP) is a result of deposition of transthyretin (TTR) in trabecular meshwork. Rarely, the amyloid deposition in anterior segment can be more exuberant than in posterior segment. A 42 years old man, with FAP (Val30Met mutation), liver transplantation in 1997. He was asymptomatic, without any significant ocular abnormality until 2011...
August 24, 2017: World Journal of Transplantation
https://www.readbyqxmd.com/read/28889348/treatment-of-erythemato-telangiectatic-rosacea-with-brimonidine-alone-or-combined-with-vascular-laser-based-on-preliminary-instrumental-evaluation-of-the-vascular-component
#20
Giuseppe Micali, Federica Dall'Oglio, Anna Elisa Verzì, Ivano Luppino, Karishma Bhatt, Francesco Lacarrubba
The purpose of this study is to evaluate the outcome of a series of patients with erythematotelangiectatic rosacea (ETR) affected by persistent erythema and varying degree of telangiectasias being treated with brimonidine alone or combined with a vascular laser based on the type of vascular components preliminarily evaluated by clinical and instrumental observation. Ten patients affected by ETR were enrolled in a pilot, open study. Instrumental evaluation included erythema-directed digital photography by VISIA-CR™ system and X10 dermoscopy...
September 9, 2017: Lasers in Medical Science
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