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https://www.readbyqxmd.com/read/28915286/treatment-of-rosacea-with-concomitant-use-of-topical-ivermectin-1-cream-and-brimonidine-0-33-gel-a-randomized-vehicle-controlled-study
#1
Linda Stein Gold, Kim Papp, Charles Lynde, Edward Lain, Melinda Gooderham, Sandra Johnson, Nabil Kerrouche
BACKGROUND: There is currently a lack of data on the simultaneous treatment of different features of rosacea. Individually, ivermectin 1% (IVM) cream and brimonidine 0.33% (BR) gel have demonstrated efficacy on inflammatory lesions and persistent erythema, respectively. OBJECTIVE: To evaluate the efficacy, safety, patient satisfaction, and optimal timing of administration of IVM associated with BR (IVM+BR) versus their vehicles in rosacea (investigator global assessment [IGA] ≥3)...
September 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28900607/de-novo-intraocular-amyloid-deposition-after-hepatic-transplantation-in-familial-amyloidotic-polyneuropathy
#2
Ivo Filipe Gama, Leonor Duarte Almeida
The familiar amyloid polyneuropathy (FAP) is a rare autosomal-dominant systemic amyloidosis. Amyloid deposition occurs more frequently and extensively in the vitq. The increase in intraocular pressure (IOP) is a result of deposition of transthyretin (TTR) in trabecular meshwork. Rarely, the amyloid deposition in anterior segment can be more exuberant than in posterior segment. A 42 years old man, with FAP (Val30Met mutation), liver transplantation in 1997. He was asymptomatic, without any significant ocular abnormality until 2011...
August 24, 2017: World Journal of Transplantation
https://www.readbyqxmd.com/read/28889348/treatment-of-erythemato-telangiectatic-rosacea-with-brimonidine-alone-or-combined-with-vascular-laser-based-on-preliminary-instrumental-evaluation-of-the-vascular-component
#3
Giuseppe Micali, Federica Dall'Oglio, Anna Elisa Verzì, Ivano Luppino, Karishma Bhatt, Francesco Lacarrubba
The purpose of this study is to evaluate the outcome of a series of patients with erythematotelangiectatic rosacea (ETR) affected by persistent erythema and varying degree of telangiectasias being treated with brimonidine alone or combined with a vascular laser based on the type of vascular components preliminarily evaluated by clinical and instrumental observation. Ten patients affected by ETR were enrolled in a pilot, open study. Instrumental evaluation included erythema-directed digital photography by VISIA-CR™ system and X10 dermoscopy...
September 9, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28889125/brimonidine-protects-auditory-hair-cells-from-in-vitro-induced-toxicity-of-gentamicin
#4
Maurizio Cortada, Soledad Levano, Daniel Bodmer
Brimonidine, an alpha-2 adrenergic receptor (α2-AR) agonist, has neuroprotective effects in the visual system and in spiral ganglion neurons. Auditory hair cells (HCs) express all 3 α2-AR subtypes, but their roles in HCs remain unknown. This study investigated the effects of brimonidine on auditory HCs that were also exposed to gentamicin, which is toxic to HCs. Organ of Corti explants were exposed to gentamicin in the presence or absence of brimonidine, and the α2-AR protein expression levels and Erk1/2 and Akt phosphorylation levels were determined...
September 9, 2017: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/28874390/brimonidine-gel-and-adverse-cardiovascular-effects
#5
(no author information available yet)
No abstract text is available yet for this article.
September 5, 2017: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/28865952/sedative-and-physiological-effects-of-brimonidine-tartrate-ophthalmic-solution-in-healthy-cats
#6
Niwako Ogata, Teppei Kanda, Mizuki Kawahata, Takayasu Ichikawa, Yuki Matsumoto, Waka Morimitsu, Yukiko Nishino, Takamasa Itoi, Kayo Furumoto
OBJECTIVE: To determine the effects of brimonidine tartrate ophthalmic solution on sedation, heart rate (HR), respiratory frequency (fR), rectal temperature (RT) and noninvasive mean arterial pressure (MAP) in healthy cats. STUDY DESIGN: Randomized, blinded crossover study, with 1 week washout between treatments. ANIMALS: Six healthy purpose-bred cats. METHODS: Brimonidine tartrate ophthalmic solution 0.1% (one or two drops; 58...
July 3, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/28859698/validated-hplc-dad-method-for-the-simultaneous-determination-of-six-selected-drugs-used-in-the-treatment-of-glaucoma
#7
Mostafa M Baker, Tarek S Belal
This work presents a simple, sensitive, and generic HPLC–diode-array detection method for the simultaneous determination of six drugs prescribed for the treatment of open-angle glaucoma and ocular hypertension. The investigated drugs include brimonidine tartarate (BMN), acetazolamide (AZA), brinzomaide (BZA), dorzolamide HCl (DZA), levobunolol HCl (LVB), and timolol maleate (TIM). Efficient chromatographic separation was achieved using a Thermo Hypersil BDS C18 column (4.6 × 250 mm, 5 µm) with a mobile phase consisting of phosphate buffer pH 5 and acetonitrile in a ratio of 78 + 22...
September 1, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28856599/erratum-to-multicenter-randomized-investigator-masked-study-comparing-brimonidine-tartrate-0-1-and-timolol-maleate-0-5-as-adjunctive-therapies-to-prostaglandin-analogues-in-normal-tension-glaucoma
#8
Shiro Mizoue, Koji Nitta, Motohiro Shirakashi, Akiyoshi Nitta, Shigeki Yamabayashi, Tairo Kimura, Toshihiko Ueda, Ryuji Takeda, Shun Matsumoto, Keiji Yoshikawa
No abstract text is available yet for this article.
August 30, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28837365/oxymetazoline-hydrochloride-cream-for-facial-erythema-associated-with-rosacea
#9
Nupur U Patel, Shweta Shukla, Jessica Zaki, Steven R Feldman
Rosacea is a chronic skin condition characterized by transient and persistent erythema of the central face. The symptom of persistent erythema can be particularly frustrating for both patients and physicians as it is difficult to treat. Areas covered: Current treatment options for the treatment of rosacea include metronidazole, azelaic acid, sodium sulfacetamide-sulfur, and brimonidine. Until recently, brimonidine gel was the only option approved specifically for the treatment of facial erythema. However, oxymetazoline hydrochloride 1% cream is a newly FDA approved topical medication for adult rosacea patients...
August 24, 2017: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/28825921/pure-glaucoma-drugs-are-toxic-to-immortalized-human-corneal-epithelial-cells-but-they-do-not-destabilize-lipid-membranes
#10
Alexandra Robciuc, Joanna Witos, Suvi-Katriina Ruokonen, Antti H Rantamäki, Pierre-Jean Pisella, Susanne K Wiedmer, Juha M Holopainen
PURPOSE: Most pure glaucoma drugs (pGDs) are hydrophobic substances intended to reduce elevated intraocular pressure. The aims of our study were to determine the toxicity of pGDs (brimonidine tartrate, brinzolamide, latanoprost, timolol maleate, and pilocarpine hydrochloride) on ocular surface cells and to establish whether their toxicity is subsequent to cellular membrane destabilization. METHODS: The toxicity of clinically efficient doses of pGDs was measured at different time points in a cell culture of human corneal epithelial cells using a redox indicator...
October 2017: Cornea
https://www.readbyqxmd.com/read/28819134/long-term-glaucoma-drug-delivery-using-a-topically-retained-gel-microsphere-eye-drop
#11
Morgan V Fedorchak, Ian P Conner, Joel S Schuman, Anthony Cugini, Steven R Little
The purpose of this study was to characterize and determine the efficacy of a long-term, non-invasive gel/microsphere (GMS) eye drop for glaucoma. This novel drug delivery system is comprised of a thermoresponsive hydrogel carrier and drug-loaded polymer microspheres. In vitro release of brimonidine from the GMS drops and gel properties were quantified. A single brimonidine-loaded GMS drop was administered to 5 normotensive rabbits and intraocular pressure (IOP) was monitored for 28 days. Here we report that IOP reduction in rabbits receiving a single brimonidine GMS drop was comparable to that of rabbits receiving twice daily, standard brimonidine drops...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28794954/cationic-supramolecular-hydrogels-for-overcoming-the-skin-barrier-in-drug-delivery
#12
David Limón, Claire Jiménez-Newman, Mafalda Rodrigues, Arántzazu González-Campo, David B Amabilino, Ana C Calpena, Lluïsa Pérez-García
A cationic bis-imidazolium-based amphiphile was used to form thermoreversible nanostructured supramolecular hydrogels incorporating neutral and cationic drugs for the topical treatment of rosacea. The concentration of the gelator and the type and concentration of the drug incorporated were found to be factors that strongly influenced the gelling temperature, gel-formation period, and overall stability and morphology. The incorporation of brimonidine tartrate resulted in the formation of the most homogeneous material of the three drugs explored, whereas the incorporation of betamethasone resulted in a gel with a completely different morphology comprising linked particles...
August 2017: ChemistryOpen
https://www.readbyqxmd.com/read/28774517/normal-tension-glaucoma-management-a-survey-of-contemporary-practice
#13
Richard J Symes, Frederick S Mikelberg
OBJECTIVE: The aim of this study was to investigate contemporary practice patterns with respect to normal tension glaucoma (NTG) management and to determine whether the 2 largest NTG trials have influenced ophthalmologists' clinical practice. METHODS: A survey questionnaire was sent to ophthalmologists via the American Glaucoma Society, the Canadian Glaucoma Society, and the Canadian Ophthalmological Society. The questionnaire was designed to investigate ophthalmologists' usual practice with respect to NTG and the extent to which practice has been influenced by the Collaborative Normal Tension Glaucoma Study (CNTGS) and the Low pressure Glaucoma Treatment Study (LoGTS)...
August 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28761569/efficacy-and-safety-of-switching-from-prostaglandin-analog-therapy-to-prostaglandin-timolol-fixed-combination-or-prostaglandin-brimonidine-therapy
#14
Kenji Inoue, Mieko Masumoto, Kyoko Ishida, Goji Tomita
BACKGROUND: To compare the safety and efficacy between switching to prostaglandin/timolol fixed combination eye drops (PG/timolol FCs) and adding brimonidine to PG analogue monotherapy. METHODS: Eyes of 53 patients with primary open-angle glaucoma or ocular hypertension who were receiving PG analogue monotherapy were included. Participants were randomly divided into two treatment groups: one was prescribed PG/timolol FCs (switched group), and for the other, 0.1% brimonidine was added to the PG analogue (added group)...
2017: Open Ophthalmology Journal
https://www.readbyqxmd.com/read/28740369/spotlight-on-brimonidine-topical-gel-0-33-for-facial-erythema-of-rosacea-safety-efficacy-and-patient-acceptability
#15
REVIEW
Michael S Anderson, Anish Nadkarni, Leah A Cardwell, Hossein Alinia, Steven R Feldman
BACKGROUND: Brimonidine tartrate is a highly selective alpha 2 agonist that induces direct vasoconstriction of small arteries and veins, thereby reducing vasodilation and edema. OBJECTIVE: To review the current literature regarding the safety, efficacy, and patient acceptability of brimonidine 0.33% gel. METHODS: A PubMed search was performed using the terms brimonidine 0.33% gel, rosacea, safety, efficacy, and acceptability. Peer-reviewed clinical trials and case reports from 2012 to 2016 were screened for inclusion of safety, efficacy, and/or patient acceptability data...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28727804/effects-of-pre-surgical-administration-of-prostaglandin-analogs-on-the-outcome-of-trabeculectomy
#16
Takako Miki, Tomoko Naito, Miyuki Fujiwara, Ryoichi Araki, Rieko Kiyoi, Yusuke Shiode, Atsushi Fujiwara, Yuki Morizane, Fumio Shiraga
For primary open angle glaucoma (POAG), laser treatment or surgery is used when the target intraocular pressure (IOP) cannot be achieved by pharmacological agents, such as prostaglandin (PG) analogs; these drugs also have varied effects. We retrospectively reviewed the medical records of 74 POAG patients (74 eyes) whose IOP was inadequately controlled by PG analogs (bimatoprost [13 eyes], latanoprost [34 eyes], tafluprost [11 eyes], and travoprost [16 eyes]) and underwent primary trabeculectomy. The proportion of patients with no recurrent IOP elevation within 24 months post-trabeculectomy was significantly (P < 0...
2017: PloS One
https://www.readbyqxmd.com/read/28692596/inadvertent-cyclodialysis-cleft-and-hypotony-following-ab-interno-trabeculotomy-using-the-trabectome-device-requiring-surgical-repair
#17
Thomas A Berk, Jella A An, Iqbal Ike K Ahmed
PURPOSE: To report the first case of inadvertent cyclodialysis cleft and hypotony requiring surgical repair following ab-interno trabeculotomy (AIT) using the Trabectome device, and the postoperative clinical results following direct suture cyclopexy. METHODS: A 55-year-old man with hypotonous maculopathy secondary to cyclodialysis cleft inadvertently created 3 years earlier during AIT using the Trabectome device was referred for repair. Direct suture cyclopexy was performed and topical homatropine and dexamethasone drops were prescribed postoperatively...
July 7, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28674856/brimonidine-timolol-versus-brinzolamide-timolol-for-treatment-of-elevated-intraocular-pressure-after-phacoemulsification-surgery
#18
Selahattin Balsak, Ayhan Kaydu, Seyfettin Erdem, M Fuat Alakus, Zeynep Gursel Ozkurt
PURPOSE: To compare the efficacy of the fixed combination of brimonidine-timolol (FCBT) and the fixed combination of brinzolamide-timolol (FCBZT) treatments for elevated intraocular pressure (IOP) after phacoemulsification cataract surgery. METHODS: A randomised, prospective, double-blinded study was conducted on 277 eyes of 257 patients who underwent phacoemulsification cataract surgery. Patients were divided into three groups based on the medication administered after cataract surgery as follows: FCBT, FCBZT and a control group where no antiglaucoma medications were used...
July 3, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28662278/topical-brimonidine-gel-for-extended-duration-local-anesthesia
#19
Hyun Jung Kwon, Sang Ju Lee, Jae Min Kim, Kui Young Park
Clinicians have been increasingly using topical anesthetic agents to diminish the pain associated with dermatologic and cosmetic procedures. Among the developed topical anesthetics, lidocaine-based products are the most widely used due to their ample pain relief and minimal side effects.(1) Many local anesthetics and additional techniques have been developed, but the limited duration of local anesthesia is still challenging to the practitioners. This article is protected by copyright. All rights reserved.
June 29, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28656780/brimonidine-and-brinzolamide-for-treating-glaucoma-and-ocular-hypertension-a-safety-evaluation
#20
REVIEW
Jed Asher Lusthaus, Ivan Goldberg
Brimonidine tartrate and brinzolamide eye drops are often used as third and fourth line treatment options to reduce intraocular pressure (IOP) in the management of glaucoma and ocular hypertension. Better tolerated, more effective topical agents requiring once daily instillation including prostaglandin analogues and beta-blockers usually are preferred as initial therapy, unless there are contraindications. Brimonidine and brinzolamide are often required owing to progressive glaucoma or intolerances to or ineffectiveness of front-line agents...
September 2017: Expert Opinion on Drug Safety
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