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https://www.readbyqxmd.com/read/28513500/rescue-vitrectomy-with-blocked-artery-massage-and-bloodletting-for-branch-retinal-artery-occlusion
#1
Chun-Ju Lin, Cheng-Wen Su, Huan-Sheng Chen, Wen-Lu Chen, Jane-Ming Lin, Yi-Yu Tsai
A 61-year-old male suffered from sudden blurred vision and superior visual field defect oculus dexter. His vision was counting fingers at 20 cm. Fundoscopy demonstrated inferior pale retina and a large embolus located at the proximal inferior retinal artery. Branch retinal artery occlusion (BRAO) was diagnosed. Initial paracentesis, topical brimonidine tartrate, oral pentoxifylline, and hyperbaric oxygen therapy were performed but showed limited improvement. Hence, he received 25-gauge vitrectomy, artificial posterior vitreous detachment, blocked retinal artery massage, and bloodletting 5 days after onset...
April 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28508306/multicenter-randomized-investigator-masked-study-comparing-brimonidine-tartrate-0-1-and-timolol-maleate-0-5-as-adjunctive-therapies-to-prostaglandin-analogues-in-normal-tension-glaucoma
#2
Shiro Mizoue, Koji Nitta, Motohiro Shirakashi, Akiyoshi Nitta, Shigeki Yamabayashi, Tairo Kimura, Toshihiko Ueda, Ryuji Takeda, Shun Matsumoto, Keiji Yoshikawa
INTRODUCTION: This study compared the efficacy and safety of adjunctive brimonidine tartrate 0.1% ophthalmic solution (brimonidine) and timolol maleate 0.5% ophthalmic solution (timolol) in prostaglandin analogue (PGA)-treated normal-tension glaucoma (NTG), assessing the non-inferiority of brimonidine in terms of intraocular pressure (IOP) reduction. METHODS: In this multicenter, randomized, investigator-masked, parallel-group, clinical study, adjunctive brimonidine or timolol was administered twice daily for 12 weeks in eyes with NTG that had been treated with PGA for at least 90 days and required additional treatment despite an IOP of 16 mmHg or less...
May 15, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28488447/increasing-efficacy-and-reducing-systemic-absorption-of-brimonidine-tartrate-ophthalmic-gels-in-rabbits
#3
Xiaochen Pang, Jiawei Li, Jiaxin Pi, Dongli Qi, Pan Guo, Nan Li, Yumei Wu, Zhidong Liu
Systemic absorption of ocularly administered Brimonidine Tartrate has been reported to give rise to several side-effects. Hence, it has become crucial to develop a delivery system that could increase efficacy and reduce systemic absorption. Therefore, the present work aims to develop Brimonidine Tartrate gels with different concentrations (0.05%, 0.1% and 0.2% w/v, respectively) using Carbopol 974P and HPMC E4M, and compare the therapeutic efficacy and systemic absorption with that of eye drop (0.2%, w/v) by UPLC-MS/MS...
May 10, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/28470857/effect-of-0-2-brimonidine-and-0-2-0-5-brimonidine-timolol-on-intraocular-pressure-and-pupil-size-in-normal-equine-eyes
#4
M VonZup, M Lassaline, P H Kass, P E Miller, S M Thomasy
BACKGROUND: Brimonidine is an alpha 2-adrenergic agonist that decreases aqueous humor production and may increase uveoscleral outflow. It has not been evaluated in normal or glaucomatous equine eyes. OBJECTIVES: To evaluate the IOP-lowering efficacy and safety of brimonidine, alone and in conjunction with timolol, as a treatment for equine glaucoma by comparing IOP in normal equine eyes treated with brimonidine and brimonidine-timolol to control eyes. STUDY DESIGN: A balanced crossover design with 16 horses receiving one of two treatments, brimonidine and brimonidine-timolol, during each of two 10-day study phases, was used...
May 4, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/28403392/association-of-central-nervous-system-depression-with-topical-brimonidine-when-used-for-hemostasis-a-serious-adverse-event
#5
Devorah R Shagalov, Drew Taylor, Rachel Schleichert, Jonathan Weiss, Eduardo Weiss
Importance: Minor bleeding is the most common complication of dermatologic surgery. Topical brimonidine, 0.33%, gel has been reported for the use of hemostasis in dermatologic surgery. The safety profile and risk of systemic toxic effects when brimonidine is used topically for hemostasis is unknown. Objective: To determine the risk of systemic toxic effects of topical brimonidine, 0.33%, gel when used for hemostasis. Design, Setting, and Participants: In this case series from a private practice (Hollywood Dermatology), 2 patients presented for dermatologic procedures, complicated by persistent bleeding...
April 12, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28368997/use-of-ocular-hypotensive-medications-in-portugal-pem-study-a-cross-sectional-nationwide-analysis
#6
David Cordeiro Sousa, Inês Leal, Nilton Nascimento, Carlos Marques-Neves, Anja Tuulonen, Luís Abegão Pinto
PURPOSE: There is scarcity of European data about intraocular pressure (IOP)-lowering prescribing patterns. We aimed to describe and discuss the nationwide prescription of these medications in Portugal. MATERIALS AND METHODS: This was a cross-sectional study including all patients who were prescribed at least 1 IOP-lowering medication in 2015 in Portugal. All ocular hypotensive drug prescriptions were gathered from the common electronic drug prescription system used by all hospitals and clinics in Portugal...
April 10, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28297016/bradycardia-in-a-child-after-using-brimonidine-as-toothpaste
#7
Abby J Montague, Stacey Bangh, Jon B Cole
No abstract text is available yet for this article.
April 1, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28251075/intraocular-pressure-with-rebound-tonometry-and-effects-of-topical-intraocular-pressure-reducing-medications-in-guinea-pigs
#8
Yue Di, Xiu-Mei Luo, Tong Qiao, Na Lu
AIM: To investigate the intraocular pressure (IOP) of adult guinea pig eyes with rebound tonometry (RBT), and assess the effects of four distinctive topical IOP reducing medications including Carteolol, Brimonidine, Brinzolamide and Latanoprost. METHODS: The IOPs of twenty-four 12-week-old guinea pigs (48 eyes) were measured every two hours in one day with RBT as baselines. All the animals were then divided into four groups (Carteolol, Brimonidine, Brinzolamide and Latanaprost groups, n=6)...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28231380/perioperative-medications-for-preventing-temporarily-increased-intraocular-pressure-after-laser-trabeculoplasty
#9
REVIEW
Linda Zhang, Jennifer S Weizer, David C Musch
BACKGROUND: Glaucoma is the international leading cause of irreversible blindness. Intraocular pressure (IOP) is the only currently known modifiable risk factor; it can be reduced by medications, incisional surgery, or laser trabeculoplasty (LTP). LTP reduces IOP by 25% to 30% from baseline, but early acute IOP elevation after LTP is a common adverse effect. Most of these IOP elevations are transient, but temporarily elevated IOP may cause further optic nerve damage, worsening of glaucoma requiring additional therapy, and permanent vision loss...
February 23, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28217551/cost-effectiveness-of-glaucoma-management-with-monotherapy-medications-in-egypt
#10
Amal Abd-Elaal El-Khamery, Amir Ibrahim Mohamed, Hassan Eisa Hassan Swify, Alaa Ibrahim Mohamed
Glaucoma is a serious chronic ophthalmic disease since it causes irreversible visual disability if untreated can lead to blindness. Treatment options include medications (classified into five major classes of drugs which are muscarinic cholinergic agonists, alpha-2 adrenergic agonists, beta-1 adrenergic antagonists, prostaglandins [PGs], and carbonic anhydrase inhibitors); use of laser therapy or conventional surgery. Pharmacoeconomic analysis helps in choosing among this variety of treatments. There is a great need for such analysis in Egypt since undergoing of it in different countries or societies may produce different results...
January 2017: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/28198606/sustained-release-of-brimonidine-from-a-new-composite-drug-delivery-system-for-treatment-of-glaucoma
#11
Jianguo Sun, Yuan Lei, Zhaoxing Dai, Xi Liu, Taomin Huang, Jihong Wu, Zhi Ping Xu, Xinghuai Sun
A novel layered double hydroxide (LDH) nanoparticle/thermogel composite drug delivery system (DDS) for sustained release of brimonidine (Bri) has been designed, prepared, and characterized in this study for treatment of severe glaucoma. Brimonidine is first loaded onto LDH (Bri@LDH) nanoparticles, which are then dispersed in the thermogel consisting of plenty of micelles based on poly(dl-lactic acid-co-coglycolic acid)-polyethylene glycol-poly(dl-lactic acid-co-coglycolic acid) (PLGA-PEG-PLGA) copolymer. The Bri@LDH/Thermogel DDS containing 125...
February 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28151873/bimatoprost-induced-late-onset-choroidal-detachment-after-trabeculectomy-a-case-report-and-review-of-the-literature
#12
Shunsuke Nakakura, Asuka Noguchi, Hitoshi Tabuchi, Yoshiaki Kiuchi
BACKGROUND: Choroidal detachment (CD) is often observed at an early period particularly after trabeculectomy and glaucoma drainage implant surgery. However, topical antiglaucoma eye drop-induced CD is a rare complication. Here, we report a case of topical bimatoprost-induced late-onset CD after trabeculectomy and review the literature. CASE REPORT: A 74-year-old man who suffered from primary open-angle glaucoma underwent his initial trabeculectomy with mitomycin-C in the right eye...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28139145/a-case-report-of-combination-treatment-with-potassium-titanyl-phosphate-laser-and-brimonidine-topical-gel-in-erythematotelangiectatic-rosacea
#13
M A Hofmann, G Kokolakis
Laser therapies have been shown to provide symptom improvement in patients with erythema and telangiectasia of rosacea; however, they are associated with side effects such as erythema. Combinatorial treatment with pharmacological agents and laser have demonstrated better efficacy, fewer side effects and continued long-term remission compared with monotherapies. A case of moderate facial erythema that responded well to combination treatment with brimonidine 3 mg/g gel and a treatment course of potassium-titanyl phosphate (KTP) laser therapy is presented, showing a reduction from baseline, maintained after final laser session, by applying brimonidine 3 mg/g gel daily...
January 31, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/28129020/the-24-hour-effects-of-brinzolamide-brimonidine-fixed-combination-and-timolol-on-intraocular-pressure-and-ocular-perfusion-pressure
#14
Leonard K Seibold, Peter E DeWitt, Miranda E Kroehl, Malik Y Kahook
PURPOSE: To determine the 24-h effects of brinzolamide/brimonidine tartrate 1%/0.2% fixed combination (BBFC) on intraocular pressure (IOP), ocular perfusion pressure (OPP), blood pressure (BP), and heart rate (HR). METHODS: Sixty subjects with open angle glaucoma (OAG) or ocular hypertension (OHTN) were admitted overnight for 24-h monitoring of IOP, BP, and HR. All subjects underwent the first, baseline 24-h study after washout of all medications, if necessary. Subjects were then randomized to receive either (1) timolol maleate 0...
April 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28122126/neuroprotection-for-treatment-of-glaucoma-in-adults
#15
REVIEW
Dayse F Sena, Kristina Lindsley
BACKGROUND: Glaucoma is a heterogeneous group of conditions involving progressive damage to the optic nerve, deterioration of retinal ganglion cells, and ultimately visual field loss. It is a leading cause of blindness worldwide. Open angle glaucoma (OAG), the most common form of glaucoma, is a chronic condition that may or may not present with increased intraocular pressure (IOP). Neuroprotection for glaucoma refers to any intervention intended to prevent optic nerve damage or cell death...
January 25, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28089013/brimonidine-tartrate-0-33-gel-for-the-management-of-posttreatment-erythema-induced-by-laser-skin-resurfacing
#16
Stephan Alexander Braun, Ofir Artzi, Peter Arne Gerber
No abstract text is available yet for this article.
February 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28034861/dtb-select-1-january-2017
#17
(no author information available yet)
Brimonidine gel: risk of exacerbation of rosacea ● Metformin for patients with moderately reduced kidney function ● Effect of an optimal cranberry dose on bacteriuria ● Amitriptyline and topiramate ineffective for paediatric migraine prophylaxis ● Etoricoxib: 60mg dose for RA and ankylosing spondylitis ● CRP and diagnosis of CAP ● International travel and antimicrobial resistance ● Effect of telemedicine on diabetes control.
January 2017: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/27995209/respiratuvar-depression-after-accidental-nasal-ingestion-of-brimonidine-eye-drops-in-infant
#18
Ali Gunes, Hasan Balik, Servet Yel, Halil Kocamaz, Mehmet Bosnak
OBJECTIVES: Brimonidine tartrate is an alpha-2 agonist used for glaucoma treatment. It can lead to serious poisoning symptoms when misused by children. CASE REPORT: In this case report, 3 months-old male patient with severe central nervous system depression and respiratory arrest as a result of accidentally nasal instillation of 1 cc brimonidine tartrate that benefited from mechanic ventilation and naloxone treatment was presented. CONCLUSION: This case report suggested, that misuse of nasal brimonidine eye drop could result in serious respiratory distress and central nervous system depression...
December 2016: Turkish Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27990376/management-of-glaucoma-in-pregnancy-risks-or-choices-a-dilemma
#19
REVIEW
Harinder Singh Sethi, Mayuresh Naik, Vishnu Swarup Gupta
The treatment of glaucoma in and around pregnancy offers the unique challenge of balancing the risk of vision loss to the mother as against the potential harm to the fetus or newborn. Most anti-glaucoma drugs (i.e. beta-blockers, prostaglandin analogues, carbonic anhydrase inhibitors topical and systemic, cholinergics, anticholinesterases, and apraclonidine) are considered category C agents and ophthalmologists are usually limited to treating patients with the category B drugs of brimonidine and dipivefrin...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/27930371/effect-of-low-concentration-nonmydriatic-selective-alpha-adrenergic-agonist-eyedrops-on-upper-eyelid-position
#20
Taís B Mendonça, Atauíne P Lummertz, Francisco J L Bocaccio, Fernando Procianoy
BACKGROUND: Ptosis after botulinum toxin injection is a disturbing complication. Decongestant and antiglaucoma eyedrops are frequently prescribed for temporary improvement of eyelid ptosis. Although frequently cited on informal communications, the effect of these drugs on eyelid position has never been compared in a formal study. OBJECTIVE: To measure the effect of low-concentration, nonmydriatic selective alpha agonist eyedrops on upper eyelid position. METHODS AND MATERIALS: This nonrandomized clinical trial enrolled 20 healthy subjects aged 18 to 50 years...
February 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
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