Yong Ma, Garima Singhal, Suzanne S Chan, Chaoqun Wang, Hongjun Yu, Bing Yin, Jing Pang, Grace Malvar, Imad Nasser, Marie L Mather, Eleftheria Maratos-Flier
BACKGROUND: Liver ischaemia/reperfusion (I/R) injury, which is an inevitable clinical problem of liver resection, liver transplantation and haemorrhagic shock. Fibroblast growth factor 21 (FGF21) was intimately coupled with multiple metabolic processes and proved to protect against apoptosis and inflammatory response in hepatocytes during hepatic I/R injury. However, the regulatory mechanisms of FGF21 in hepatic I/R injury remains unknown. Therefore, we hypothesize that FGF21 protects hepatic tissues from I/R injury...
March 30, 2024: Liver International: Official Journal of the International Association for the Study of the Liver