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Haemangioma

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https://www.readbyqxmd.com/read/29774538/oral-propranolol-in-the-treatment-of-proliferating-infantile-haemangiomas-the-british-society-for-paediatric-dermatology-consensus-guidelines
#1
L Solman, M Glover, P E Beattie, H Buckley, S Clark, J E Gach, A Giardini, I Helbling, R J Hewitt, B Laguda, S M Langan, A E Martinez, R Murphy, L Proudfoot, J Ravenscroft, H Shahidullah, L Shaw, S B Syed, L Wells, C Flohr
BACKGROUND: Infantile haemangiomas (IH) are the most common vascular tumours of infancy. Despite their frequency and potential complications, there are currently no unified UK guidelines for the treatment of IH with propranolol. There are still uncertainties and diverse opinions regarding indications, pre-treatment investigations, its use in PHACES syndrome, and cessation of treatment. METHODS: This study used a modified Delphi technique, which involved an international treatment survey, a systematic evidence review of the literature, a face-to-face multidisciplinary panel meeting and anonymous voting...
May 17, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29774221/magnetic-resonance-imaging-findings-for-differential-diagnosis-of-perianal-plexiform-schwannoma-case-report-and-review-of-the-literature
#2
Xue-Liang Sun, Ke Wen, Zhi-Zhong Xu, Xiao-Peng Wang
Plexiform schwannoma is an extremely rare variant of schwannoma, accounting for approximately 5% of cases. Due to the rarity and lack of typical symptoms, signs and radiological images, a definite diagnosis of plexiform schwannoma may not be made by clinicians prior to biopsy. In the present study, we report the first case (to our knowledge) of perianal plexiform schwannoma arising from the overlapped skin of the ischioanal fossa, and we propose an intratumorally nonenhanced circumferential capsule dividing the tumour into multiple homogeneously enhanced nodules as a magnetic resonance imaging feature to aid in the differential diagnosis of plexiform schwannoma from ancient schwannoma, cavernous haemangioma, liposarcoma and plexiform neurofibroma...
May 16, 2018: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/29754133/solitary-calvarial-haemangioma-presenting-as-metastatic-renal-cell-carcinoma
#3
Calver Pang, Yew Loong Loo, Robert Corns, Rasheed Mohammed
Renal cell carcinoma is the most common renal tumour in adult that often metastasises to the lung, liver or bone. Head and neck lesions are uncommon with no early warning signs and presents with overt metastases at primary presentation in 25%-30% of reported cases. The incidence of haemangiomas that suggest malignancy are similar to that of bone metastasis. Calvarial haemangiomas usually present as asymptomatic and discovered incidentally on imaging or postmortem examination. We report a case where an initial diagnosis of benign tumour of the skull was made based on clinical presentation and calvarial haemangioma on CT head but was confirmed as metastatic clear cell carcinoma of the kidney after histopathological results...
May 12, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29740524/fractionated-external-beam-radiation-therapy-for-incompletely-resected-intracranial-extra-axial-cavernous-haemangioma-a-case-report
#4
Kiat Huat Ooi, Shiong Wen Low
We report a case of a cavernous haemangioma arising from the left trigeminal nerve causing mass effect, midline shift and hydrocephalus. Surgical resection was attempted after immediate insertion of bilateral extra-ventricular drains, but complete resection was not achieved, with residual disease at the superior orbital fissure and cavernous sinus. Stereotactic radiosurgery was deemed unsuitable in view of proximity to the left optic nerve and optic chiasm, and the patient was hence treated with fractionated external-beam radiation therapy (RT) to a total dose of 40 Gy in 20 daily fractions over four weeks...
March 7, 2018: Curēus
https://www.readbyqxmd.com/read/29703666/combining-midfacial-degloving-lefort-i-osteotomy-and-inferiorly-extended-lateral-orbitotomy-kr%C3%A3-nlein-for-removal-of-an-orbital-cavernous-haemangioma-a-new-approach
#5
M Schwaiger, J Wallner, W Zemann, M Feichtinger
Orbital tumours, located in the medial extraconal and intraconal compartment of the orbit, represent a challenge, with regard to surgical exposure. In the present paper removal of a cavernous haemangioma, located in the medial intraconal compartment was accomplished by combining lateral orbitotomy, midfacial degloving and LeFort-I osteotomy. Resection of the tumour could be performed under direct vision. Surgical exposure and removal of the lesion were obtained, without causing damage to surrounding tissues...
April 24, 2018: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29692735/mequindox-induced-genotoxicity-and-carcinogenicity-in-mice
#6
Qianying Liu, Zhixin Lei, Qin Wu, Deyu Huang, Shuyu Xie, Xu Wang, Yuanhu Pan, Zonghui Yuan
Mequindox (MEQ), acting as an inhibitor of deoxyribonucleic acid (DNA) synthesis, is a synthetic heterocyclic N -oxides. To investigate the potential carcinogenicity of MEQ, four groups of Kun-Ming (KM) mice (50 mice/sex/group) were fed with diets containing MEQ (0, 25, 55, and 110 mg/kg) for one and a half years. The result showed adverse effects on body weights, feed consumption, hematology, serum chemistry, organ weights, relative organ weights, and incidence of tumors during most of the study period. Treatment-related changes in hematology, serum chemistry, relative weights and histopathological examinations revealed that the hematological system, liver, kidneys, and adrenal glands, as well as the developmental and reproductive system, were the main targets after MEQ administration...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29671057/accurate-ivim-model-based-liver-lesion-characterisation-can-be-achieved-with-only-three-b-value-dwi
#7
P Mürtz, A M Sprinkart, M Reick, C C Pieper, A-H Schievelkamp, R König, H H Schild, W A Willinek, G M Kukuk
OBJECTIVE: The objective of this study was to evaluate a simplified intravoxel incoherent motion (IVIM) approach of diffusion-weighted imaging (DWI) with four b-values for liver lesion characterisation at 1.5 T. METHODS: DWI data from a respiratory-gated MRI sequence with b = 0, 50, 250, 800 s/mm2 were retrospectively analysed in 173 lesions and 40 healthy livers. The apparent diffusion coefficient ADC = ADC(0,800) and IVIM-based parameters D1 ' = ADC(50,800), D2 ' =ADC(250,800), f1 ', f2 ', D*', ADClow = ADC(0,50), and ADCdiff =ADClow -D2 ' were calculated voxel-wise without fitting procedures...
April 18, 2018: European Radiology
https://www.readbyqxmd.com/read/29669359/low-ct-attenuation-values-of-sinonasal-benign-tumours-relative-to-the-brainstem-identify-schwannomas
#8
Tomoaki Nakada, Shu Kikuta, Harushi Mori, Yuya Shimizu, Hironobu Nishijima, Kenji Kondo, Tatsuya Yamasoba
OBJECTIVES: On computed tomography (CT), sinonasal schwannoma displays as a soft-tissue mass without any distinctive features. Our aim was to define the radiological criteria for distinguishing schwannoma from other sinonasal benign tumours. METHODS: We retrospectively identified consecutive patients who were pathologically diagnosed with benign sinonasal tumours between 2007 and 2016. CT attenuation values were compared between benign tumours and the brainstem...
April 17, 2018: ORL; Journal for Oto-rhino-laryngology and its related Specialties
https://www.readbyqxmd.com/read/29667726/interventions-for-infantile-haemangiomas-of-the-skin
#9
REVIEW
Monica Novoa, Eulalia Baselga, Sandra Beltran, Lucia Giraldo, Ali Shahbaz, Hector Pardo-Hernandez, Ingrid Arevalo-Rodriguez
BACKGROUND: Infantile haemangiomas (previously known as strawberry birthmarks) are soft, raised swellings of the skin that occur in 3% to 10% of infants. These benign vascular tumours are usually uncomplicated and tend to regress spontaneously. However, when haemangiomas occur in high-risk areas, such as near the eyes, throat, or nose, impairing their function, or when complications develop, intervention may be necessary. This is an update of a Cochrane Review first published in 2011...
April 18, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29666688/synovial-haemangioma-of-the-elbow-a-rare-paediatric-case-and-imaging-dilemma
#10
Han G Hoe, Faizah M Zaki, Abdul H A Rashid
Synovial haemangiomas are rare benign vascular proliferations arising in synovium-lined surfaces. While the knee is by far the joint most commonly involved, this condition can also occur in the elbow. We report an eight-year-old boy who presented to the National University of Malaysia Medical Centre, Kuala Lumpur, Malaysia, in 2016 with a left elbow swelling of one year's duration. Magnetic resonance imaging showed a lobulated intra-articular mass with intermediate signal intensity on T1-weighted imaging and low signal punctate and linear structures within the hyperintense mass on T2-weighted imaging...
February 2018: Sultan Qaboos University Medical Journal
https://www.readbyqxmd.com/read/29666079/oral-superficial-haemosiderotic-lymphovascular-malformation-a-rare-presentation
#11
Manar Alhassani, Vijay Santhanam, Shadi Basyuni
We present an extremely rare case of a 53-year-old woman with an intraoral superficial haemosiderotic lymphovascular malformation (SHLM), also known as hobnail haemangioma. SHLM is a rare, benign, vascular tumour first described as targetoid haemosiderotic haemangioma, with only a handful of cases reported to present in the oral cavity. The diagnosis was established following complete surgical excision of the lesion, and after 14 months, there are still no signs of recurrence. Although SHLM is an uncommon condition, accurate and timely diagnosis is valuable in distinguishing these lesions from their more serious competing differential diagnoses...
April 17, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29665992/role-of-intralesional-bleomycin-and-intralesional-triamcinolone-therapy-in-residual-haemangioma-following-propranolol
#12
V Pandey, P Tiwari, S P Sharma, R Kumar, O P Singh
With the emergence of propranolol as the first choice of treatment for problematic infantile haemangioma at many centres, the number of patients with a partial or non-response to propranolol has also been growing. This study investigated the role of intralesional bleomycin and triamcinolone in patients with residual disease following propranolol therapy for infantile haemangioma. Sixty-seven patients with residual haemangioma were assigned randomly to receive either intralesional bleomycin (group A, n=36) or intralesional triamcinolone (group B, n=31)...
April 14, 2018: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29657122/silent-cardiac-haemangioma-of-left-ventricle-coexisting-with-vertebral-haemangioma-diagnosis-by-cardiac-magnetic-resonance-imaging
#13
Teresa Pinho, Alexandra Sousa, António J Madureira, Jorge Almeida, Mário Jorge Amorim
No abstract text is available yet for this article.
February 13, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29652858/oncosuppressors-and-oncogenes-role-in-haemangioma-genesis-and-potential-for-therapeutic-targeting
#14
REVIEW
Peace Mabeta
Genetic lesions in proto-oncogenes result in the perturbation of angiogenesis, the formation of neovessels from a pre-existing microvasculature. Similarly, the subversion of tumor suppressor genes promotes tumor vascularization. Excessive neovessel formation is associated with various neoplasms such as infantile hemangiomas (IH). Hemangiomas are the most common tumors in pediatric patients and at present have no definitive treatment. The pathogenesis of IH is not well understood; however, both vasculogenesis and angiogenesis are associated with hemangioma genesis...
April 13, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29618868/alveolar-soft-part-sarcoma-of-the-forearm
#15
B Asokan, P Ramanan, M Sundararaj, E Kovarthini
Alveolar soft part sarcoma (ASPS) is a rare form of soft-tissue sarcoma arising from connective tissue. It is most often seen in adolescents and young adults and has high propensity for recurrence and metastasis. Clinically, it mimics haemangioma or arteriovenous malformations. In our case report, an 18-year-old female presented with markedly vascular tumour in the left forearm, for which excision biopsy was done. Histopathological report revealed ASPS. The patient was screened for metastasis. Ultrasound abdomen, computed tomography (CT) chest, CT brain and whole-body skeletal survey was done...
September 2017: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/29599380/basilic-vein-haemangioma-an-unusual-differential-diagnosis-for-cubital-fossa-mass
#16
Albert Abhinay Kota, Darpa Hazra, Andrew Dheepak Selvaraj
Subcutaneous masses along the cubital fossa can be a diagnostic dilemma. Most patients are asymptomatic and usually present for a cosmetic reason. Diagnosis can be confirmed by radiological findings and histopathology. We present a case report of a similar mass that turned out to be a haemangioma arising from the basilic vein with brief review of literature.
March 28, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29594352/analysis-of-membranous-ki-67-staining-in-breast-cancer-and-surrounding-breast-epithelium
#17
Gábor Cserni
Membranous Ki-67 staining with the MIB-1 antibody has been described in hyalinising trabecular adenomas of the thyroid and sclerosing haemangiomas of the lung. Its relatively rare occurrence in breast tumours has also been documented. The aim of the present study was to assess the rate of any membranous MIB-1 staining in breast specimens. The staining was performed at room temperature with 1:100 dilution of the antibody. One hundred four core needle biopsies and 41 operative specimens were analysed. Membranous staining was noted in 36/144 invasive carcinomas, 20/42 in situ carcinomas and 46/99 cases of peritumoural benign/normal breast epithelium...
March 28, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29594078/malignant-melanoma-of-the-external-auditory-canal-a-rare-entity
#18
Yookarin Khonglah, Nabanita Das, Vandana Raphael, Ankit-Kumar Jitani, N Brian Shunyu
Introduction: Although malignant melanomas (MM) are common in the head and neck region; primary malignant melanoma of the external auditory canal (EAC) is rare. Case Report: We present the case of a 50-year-old symptomatic man with a malignant melanoma of the external auditory canal, which clinically masqueraded as a haemangioma. The patient subsequently developed extensive loco-regional metastasis, requiring extensive surgery. We describe the clinical presentation, differential diagnosis, both clinical and pathological in terms of other pigmented lesions in the external auditory canal, detailed histopathology, and literature review...
March 2018: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/29570181/-benign-liver-tumours-current-diagnostics-and-therapeutic-modalities
#19
Gergely Nagy, Katalin Dezsõ, Gergely Kiss, Zsuzsanna Gerlei, Péter Nagy, László Kóbori
The most common benign liver tumours are haemangiomas, focal nodular hyperplasia and hepatocellular adenoma. We perform a review of the literature and show the current diagnostic and therapeutic modalities based on the EASL Clinical Practice Guideline. With the widespread use of ultrasound, the detection of liver lesions is increased. They are usually found in women of childbearing age with atypical abdominal pain or incidentally. Contrast-enhanced US, CT or MRI are usually necessary for differential diagnosis...
March 23, 2018: Magyar Onkologia
https://www.readbyqxmd.com/read/29569772/topical-propranolol-for-infantile-haemangiomas-a-systematic-review
#20
REVIEW
A Price, S Rai, R W J Mcleod, J C Birchall, H A Elhassan
Infantile haemangiomas are the most common tumour of infancy. Whilst the majority are left untreated to involute spontaneously, residual skin changes commonly occur, particularly in superficial haemangiomas. The current first line treatment for problematic lesions is oral propranolol, however due to the risk of systemic adverse effects, the use of off-label topical preparations has recently been investigated. Our systematic review was conducted in accordance with PRISMA guidelines. Four databases were searched to identify original articles evaluating the use of topical propranolol as the primary therapy for infantile haemangiomas...
March 23, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
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