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https://www.readbyqxmd.com/read/28934743/early-electroencephalography-suppression-and-postnatal-morbidities-correlate-with-cerebral-volume-at-term-equivalent-age-in-very-preterm-infants
#1
Sverre Wikström, Holger Hövel, Ingrid Hansen Pupp, Vineta Fellman, Petra S Hüppi, David Ley, Lena Hellström-Westas
BACKGROUND: Early brain activity is associated with long-term outcome. Establishing a relation also with postnatal brain growth may increase our understanding of early life influences on preterm brain development. OBJECTIVES: The aim of this study was to investigate whether early electroencephalography (EEG) activity in infants born very preterm is associated with brain volumes at term, and whether postnatal morbidity affects this association. METHODS: Very preterm infants (n = 38) with a median gestational age (GA) of 25...
September 22, 2017: Neonatology
https://www.readbyqxmd.com/read/28934363/sex-related-differences-in-the-risk-factors-for-in-hospital-mortality-and-outcomes-of-ischemic-stroke-patients-in-rural-areas-of-taiwan
#2
Cheung-Ter Ong, Yi-Sin Wong, Sheng-Feng Sung, Chi-Shun Wu, Yung-Chu Hsu, Yu-Hsiang Su, Ling-Chien Hung
BACKGROUND AND PURPOSE: Sex-related differences in the clinical presentation and outcomes of stroke patients are issues that have attracted increased interest from the scientific community. The present study aimed to investigate sex-related differences in the risk factors for in-hospital mortality and outcome in ischemic stroke patients. METHODS: A total of 4278 acute ischemic stroke patients admitted to a stroke unit between January 1, 2007 and December 31, 2014 were included in the study...
2017: PloS One
https://www.readbyqxmd.com/read/28933957/the-upright-body-position-increases-translaminar-pressure-gradient-in-normotensive-and-hypertensive-rats
#3
Janusz Skrzypecki, Marcin Ufnal
AIM: Several lines of evidence suggest that the pathogenesis of glaucoma may depend on an increased translaminar pressure gradient (TPG), the difference between intraocular and intracranial pressure (ICP), rather than on intraocular pressure (IOP) itself. It has also been suggested that high blood pressure might correlate with the incidence of glaucoma; however, the data are contradictory. Here, we studied the effect of arterial blood pressure and changes in body position on TPG in rats...
September 21, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28933335/re-evaluating-ttf-1-immunohistochemistry-in-diffuse-gliomas-expression-is-clonedependent-and-associated-with-tumor-location
#4
Drew Pratt, Nina Afsar, Michael Allgauer, Patricia Fetsch, Maryknoll Palisoc, Stefania Pittaluga, Martha Quezado
TTF-1 is widely used as a marker in routine surgical pathology in the work-up of malignancy. Aberrant expression of TTF-1 in extrapulmonary and extrathyroidal malignancies is a frequently reported phenomenon. In addition to the recently characterized pituicyte-derived tumors of the sella, immunoreactivity has been reported in diffuse gliomas with the SPT24 clone. Here, we sought to evaluate TTF-1 expression with three commercially available clones in a large series of gliomas. Expression was compared across the newly defined diagnostic entities in the 2016 WHO Classification of CNS Tumors...
September 21, 2017: Clinical Neuropathology
https://www.readbyqxmd.com/read/28933214/magnetic-enhancement-of-stem-cell-targeted-delivery-into-the-brain-following-mr-guided-focused-ultrasound-for-opening-the-blood-brain-barrier
#5
Wei-Bin Shen, Pavlos Anastasiadis, Ben Nguyen, Deborah Yarnell, Paul J Yarowsky, Victor Frenkel, Paul S Fishman
Focused ultrasound (FUS)-mediated blood-brain barrier disruption (BBBD) can enable even large therapeutics such as stem cells to enter the brain from the bloodstream. However, the efficiency is relatively low. Our previous study showed that human neural progenitor cells (hNPCs) loaded with superparamagnetic iron oxide nanoparticles (SPIONs) in culture were attracted by an external magnetic field. In vivo, enhanced brain retention was observed near a magnet mounted on the skull in a rat model of traumatic brain injury, where BBBD also occurs...
July 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28933201/glioma-and-microenvironment-dual-targeted-nanocarrier-for-improved-antiglioblastoma-efficacy
#6
Xiuzhen Wang, Qing Zhang, Lingyan Lv, Junjie Fu, Yan Jiang, Hongliang Xin, Qizheng Yao
Drug delivery systems based on nanoparticles (nano-DDS) have aroused attentions for the treatment of glioblastoma (GBM), the most malignant brain cancer with a dismal prognosis. However, there are still numerous unmet challenges for traditional nano-DDS, such as the poor nanoparticle penetration, short retention in the GBM parenchyma and low glioma targeting ability. Herein, we used Pep-1 and CREKA peptides to construct a novel multifunctional GBM targeting nano-DDS (PC-NP). Pep-1 was used to overcome the blood-brain tumor barrier (BBTB) and home to glioma cells via interleukin-13 receptor-α2-mediated endocytosis, and CREKA was used to bind to fibrin-fibronectin complexes abundantly expressed in tumor microenvironment for enhanced retention in the GBM...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28932993/oxygen-therapy-with-high-flow-nasal-cannula-as-an-effective-treatment-for-perioperative-pneumocephalus-case-illustrations-and-pathophysiological-review
#7
Jason L Siegel, Karen Hampton, Alejandro A Rabinstein, Diane McLaughlin, Jose L Diaz-Gomez
Pneumocephalus (PNC) is a condition in which when air is trapped inside the intracranial vault. The causes are varied, but include trauma and intracranial surgery. Treatment of PNC typically consists of augmenting patient oxygenation with the attempt of washing out pulmonary nitrogen, creating a gradient in which nitrogen in the intracranial air bubble diffuses out of the lungs via the blood. Though several high flow methods have been tested, the ideal mode of oxygenation has not fully been investigated. Here we present 3 cases of post-operative PNC who we felt were symptomatic from PNC...
September 20, 2017: Neurocritical Care
https://www.readbyqxmd.com/read/28932923/dual-energy-bone-removal-computed-tomography-brct-preliminary-report-of-efficacy-of-acute-intracranial-hemorrhage-detection
#8
Norihito Naruto, Hidenori Tannai, Kazuma Nishikawa, Kentaro Yamagishi, Masahiko Hashimoto, Hideto Kawabe, Yuichi Kamisaki, Hisashi Sumiya, Satoshi Kuroda, Kyo Noguchi
PURPOSE: One of the major applications of dual-energy computed tomography (DECT) is automated bone removal (BR). We hypothesized that the visualization of acute intracranial hemorrhage could be improved on BRCT by removing bone as it has the highest density tissue in the head. This preliminary study evaluated the efficacy of a DE BR algorithm for the head CT of trauma patients. METHODS: Sixteen patients with acute intracranial hemorrhage within 1 day after head trauma were enrolled in this study...
September 20, 2017: Emergency Radiology
https://www.readbyqxmd.com/read/28932730/aorto-carotid-bypass-in-patients-with-takayasu-arteritis
#9
Hong Seok Han, Kyoung Won Yoon, Seon-Hee Heo, Yang Jin Park, Young-Wook Kim, Dong-Ik Kim
PURPOSE: Takayasu arteritis is an indication for bypass surgery when this condition results in severe cerebrovascular ischemia due to occlusion of the carotid arteries. We reviewed the patients with Takayasu arteritis who received aorto-carotid bypass due to cerebrovascular ischemia. METHODS: A retrospective review was performed on 19 patients with Takayasu arteritis who underwent aorto-carotid bypass from March 2002 to April 2015. RESULTS: All patients were female and the mean of their age was 40...
September 2017: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/28932186/da-negatively-regulates-igf-i-actions-implicated-in-cognitive-function-via-interaction-of-psd95-and-nnos-in-minimal-hepatic-encephalopathy
#10
Saidan Ding, Weishan Zhuge, Xuebao Wang, Jianjing Yang, Yuanshao Lin, Chengde Wang, Jiangnan Hu, Qichuan Zhuge
Insulin-like growth factor I (IGF-I) has been positively correlated with cognitive ability. Cognitive decline in minimal hepatic encephalopathy (MHE) was shown to be induced by elevated intracranial dopamine (DA). The beneficial effect of IGF-I signaling in MHE remains unknown. In this study, we found that IGF-I content was reduced in MHE rats and that IGF-I administration mitigated cognitive decline of MHE rats. A protective effect of IGF-I on the DA-induced interaction between postsynaptic density protein 95 (PSD95) and neuronal nitric oxide synthase (nNOS) was found in neurons...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28931766/differences-in-the-genotype-frequency-of-the-rnf213-variant-in-patients-with-familial-moyamoya-disease-in-kyushu-japan
#11
Yuichiro Takamatsu, Ken Higashimoto, Toshiyuki Maeda, Masatou Kawashima, Muneaki Matsuo, Tatsuya Abe, Toshio Matsushima, Hidenobu Soejima
The p.R4810K (rs11273543, c.14429G > A) variant of the RNF213 gene is associated with increased risk of Moyamoya disease (MMD), which is an idiopathic progressive intracranial vascular steno-occlusive disease, in Asian populations. Numerous variant association studies for this MMD variant have been performed in Japan to date. Since another genetic study that utilized approximately 140,000 single nucleotide polymor (SNPs) has indicated that there still are genetic differences among mainland Japanese, there is a possibility that the variant distribution in patients with MMD and normal individuals varies between different Japanese regions...
September 21, 2017: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/28931684/zika-virus-encoding-non-glycosylated-envelope-protein-is-attenuated-and-defective-in-neuroinvasion
#12
Arun S Annamalai, Aryamav Pattnaik, Bikash R Sahoo, Ezhumalai Muthukrishnan, Sathish Kumar Natarajan, David Steffen, Hiep L X Vu, Gustavo Delhon, Fernando A Osorio, Thomas M Petro, Shi-Hua Xiang, Asit K Pattnaik
Zika virus (ZIKV), a mosquito-transmitted flavivirus, responsible for sporadic outbreaks of mild and febrile illness in Africa and Asia, re-emerged in the last decade causing serious human diseases including microcephaly, congenital malformations, and Guillain-Barré syndrome. Although genomic and phylogenetic analyses suggest that genetic evolution may have led to enhanced virulence of ZIKV, experimental evidence supporting the role of specific genetic changes in virulence is currently outstanding. One sequence motif, VNDT, containing an N-linked glycosylation site in the envelope (E) protein, is polymorphic, being absent in many of the African isolates while present in all isolates from the recent outbreaks...
September 20, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28931426/effects-of-dosimetric-inadequacy-on-local-control-and-toxicities-in-the-patients-with-t4-nasopharyngeal-carcinoma-extending-into-the-intracranial-space-and-treated-with-intensity-modulated-radiotherapy-plus-chemotherapy
#13
Fen Xue, Chao-Su Hu, Xia-Yun He
BACKGROUND: To protect neurological tissues, underdosing occurs in most cases of T4 nasopharyngeal carcinoma (NPC) with intracranial extension. In this study, we aimed to evaluate the effect of dosimetric inadequacy on local control and late neurological toxicities for patients treated with intensity-modulated radiotherapy (IMRT) plus chemotherapy. METHODS: We prospectively enrolled patients who had non-metastatic T4 NPC with intracranial extension treated between January 2009 and November 2013...
September 20, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28931297/-intracranial-pressure-evaluation-by-ophthalmologist
#14
J Čmelo, R Illéš, J Šteňo
The value of ICT is important in diagnosis of the diseases of the eye and orbit Methods for direct measurement of intracranial pressure (ICT) are exact, but they are invasive and there is some risk of infection and damage of the tissue. Currently there are 2 valid indirect methods of mesurement of IKT. Digital Ophthalmodynamometry (D-ODM) and Transcranial Doppler ultrasonography (TDU). D-ODM is a non-invasive method for measuring of the Pulsating Venous Pressure (VPT). We can measure VPT by the pulse phenomena...
2017: Ceská a Slovenská Oftalmologie
https://www.readbyqxmd.com/read/28931296/-translaminar-gradient-and-glaucoma
#15
J Čmelo
OBJECTIVE: The cribriform plate is a threshold of the intraocular pressure (VOT) and of the intracranial pressure (IKT). The difference between the VOT and IKT is referred to as translaminar gradient (TLG). The goal was to evaluate the Glaucoma progression (visual field, fundus examination, HRT) with / without topical anti-glaucomatous therapy) in relation to the TLG. PATIENTS AND METHODS: the significance of TLG has been studied in two groups. I. Group: 57 patients diagnosed and treatment of Primary Open-Angle Glaucoma (PGOU), 10 patients with Ocular hypertension (OH), 7 patients with Normal-Tension Glaucoma (NTG), and 75 healthy without glaucoma...
2017: Ceská a Slovenská Oftalmologie
https://www.readbyqxmd.com/read/28931264/assessment-of-the-accuracy-and-errors-of-head-up-display-by-an-optical-neuronavigation-system-in-brain-tumor-surgery
#16
Kenichiro Asano, Kosuke Katayama, Kiyohide Kakuta, Kanae Oyama, Hiroki Ohkuma
BACKGROUND: A head-up display (HUD) in which navigational information is projected into the microscope view may enable surgeons to perform operations more efficiently. Projecting depictions of both tumor and important intracranial structures on the HUD may facilitate safe surgery. OBJECTIVE: To investigate accuracy and errors regarding important intracranial structures, errors due to brain shifts, and preservation rates for important intracranial structures. METHODS: A total of 184 surgeries in 172 patients were performed using this operation system...
February 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28931257/morphometric-analysis-of-the-middle-clinoid-process-using-maxillofacial-computed-tomography-scans
#17
Christopher Miller, Roukoz Chamoun, David Beahm
BACKGROUND: The interest in detailed anatomy of the sella and parasellar regions has resurged recently due to the wide clinical applications of the expanded endoscopic approaches to the skull base. The middle clinoid process (MCP) is a bony structure that can affect wide endoscopic exposure of the sella and parasellar region. OBJECTIVE: To study and analyze the anatomic variations of the MCP in the general population using computed tomography scans. METHODS: A total of 150 maxillofacial computed tomography scans were reviewed to characterize the MCP...
February 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28931252/a-simplified-method-of-accurate-postprocessing-of-diffusion-tensor-imaging-for-use-in-brain-tumor-resection
#18
Phillip A Bonney, Andrew K Conner, Lillian B Boettcher, Ahmed A Cheema, Chad A Glenn, Adam D Smitherman, Nathan A Pittman, Michael E Sughrue
BACKGROUND: Use of diffusion tensor imaging (DTI) in brain tumor resection has been limited in part by a perceived difficulty in implementing the techniques into neurosurgical practice. OBJECTIVE: To demonstrate a simple DTI postprocessing method performed without a neuroscientist and to share results in preserving patient function while aggressively resecting tumors. METHODS: DTI data are obtained in all patients with tumors located within presumed eloquent cortices...
February 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28931218/aberrant-humoral-immune-responses-in-neurosyphilis-cxcl13-cxcr5-play-a-pivotal-role-for-b-cell-recruitment-to-the-cerebrospinal-fluid
#19
Qian Yu, Yuanyuan Cheng, Yuanyuan Wang, Cuini Wang, Haikong Lu, Zhifang Guan, Jian Huang, Weiming Gong, Mei Shi, Liyan Ni, Juan Wu, Ruirui Peng, Pingyu Zhou
Background: Previous studies documented that humoral immune responses participated in neurological damage in neurosyphilis patients. However, the mechanisms that trigger and maintain humoral immunity involved in neurosyphilis remain unknown. Methods: Using flow cytometry, expression of B cells was measured in neurosyphilis and non-neurosyphilis. Expression of immunoglobulin indices and chemokine ligand CXCL13 was detected by enzyme-linked immunosorbent assay. The migration and inhibition assays were evaluated by modified chamber assays...
September 1, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28930970/screening-of-critical-genes-and-micrornas-in-blood-samples-of-patients-with-ruptured-intracranial-aneurysms-by-bioinformatic-analysis-of-gene-expression-data
#20
Lijuan Bo, Bo Wei, Zhanfeng Wang, Daliang Kong, Zheng Gao, Zhuang Miao
BACKGROUND This study aimed to identify more potential genes and miRNAs associated with the pathogenesis of intracranial aneurysms (IAs). MATERIAL AND METHODS The dataset of GSE36791 (accession number) was downloaded from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) were screened for in the blood samples from patients with ruptured IAs and controls, followed by functional and pathway enrichment analyses. In addition, gene co-expression network was constructed and significant modules were extracted from the network by WGCNA R package...
September 20, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
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