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asthma and bronchiectasis

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https://www.readbyqxmd.com/read/29420096/gamma-globulin-replacement-therapy-in-uncontrolled-severe-asthma-associated-with-humoral-immunodeficiency-a-series-of-five-case-reports
#1
Angelica Tiotiu, Yves Martinet, Roger Jankowski, Philippe Devillier
We report on five adult cases of the rare association of asthma with humoral immunodeficiency (huID). All patients had uncontrolled asthma related to recurrent respiratory infections. Asthma was diagnosed according to the Global Initiative for Asthma (GINA) guidelines, and bronchiectasis was ruled out by a CT chest scan. Two men (aged 28 and 60) presented with pollen allergies, chronic rhinosinusitis, and IgG deficiency (7.8 and 7.6 g/L, respectively). Both patients underwent surgery for nasal polyposis but relapsed with acute sinusitis and severe asthma exacerbations requiring treatment with oral corticosteroids and antibiotics...
February 8, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29411860/self-management-for-bronchiectasis
#2
REVIEW
Carol Kelly, Seamus Grundy, Dave Lynes, David Jw Evans, Sharada Gudur, Stephen J Milan, Sally Spencer
BACKGROUND: Bronchiectasis is a long term respiratory condition with an increasing rate of diagnosis. It is associated with persistent symptoms, repeated infective exacerbations, and reduced quality of life, imposing a burden on individuals and healthcare systems. The main aims of therapeutic management are to reduce exacerbations and improve quality of life. Self-management interventions are potentially important for empowering people with bronchiectasis to manage their condition more effectively and to seek care in a timely manner...
February 7, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29361809/-the-prevalence-of-nontuberculous-mycobacterial-lung-disease-with-orwithout-reflux-esophagitis
#3
Jae Bin Kang, Dong Ho Lee, Soo Hoon Kwon, Nayoung Kim, Young Soo Park, Hyuk Yoon, Cheol Min Shin, Yoon Jin Choi
Background/Aims: Gastrointestinal reflux disease (GERD) is defined as 'a condition that develops when the reflux of stomach contents causes troublesome symptoms and/or complications'. It is associated with various lung diseases, including bronchial asthma, chronic bronchitis, and bronchiectasis. GERD may also affect nontuberculous mycobacterial (NTM) lung disease. We presumed that the normal mucosal barrier of the bronchial epithelium is broken due to the aspiration of gastric juice and consequent chronic bronchial inflammation...
January 25, 2018: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/29314357/vitamin-d-levels-in-asthmatic-patients-with-and-without-allergic-bronchopulmonary-aspergillosis
#4
Ritesh Agarwal, Inderpaul S Sehgal, Sahajal Dhooria, Ashutosh N Aggarwal, Naresh Sachdeva, Sanjay K Bhadada, Mandeep Garg, Digambar Behera, Arunaloke Chakrabarti
Vitamin D deficiency is believed to a pathogenetic factor in patients with allergic bronchopulmonary aspergillosis (ABPA) and cystic fibrosis. Whether vitamin D deficiency is also prevalent in ABPA complicating asthma, remains unknown. Herein, we evaluate vitamin D levels in asthmatic patients with and without ABPA. In a prospective study, plasma vitamin D (25[OH]D) levels were measured in consecutive subjects with asthma (n=75), ABPA (n=158) and healthy volunteers (n=50). Vitamin D levels <20 ng/mL were considered as vitamin D deficiency...
January 4, 2018: Mycoses
https://www.readbyqxmd.com/read/29245242/different-evolution-in-the-treatment-of-a-severe-persistent-asthma-in-2-twins-case-report-and-review-of-the-literature
#5
REVIEW
Ileana Ioniuc, Ingrith Miron, Ancuta Ignat, Vasile Valeriu Lupu, Cristina Gavrilovici, Magdalena Starcea, Elena Cristina Mitrofan, Alina Murgu
RATIONALE: Asthma is a multifactorial disease with complex genetic inheritance. In children under the age of 5 years, the diagnosis of asthma is a challenge. PATIENT CONCERN: We present the case of twin sisters under the same treatment for persistent asthma, but with different evolution over the time. DIAGNOSES: One of the sister is diagnosed with severe persistent bronchial asthma associated with bronchiectasis and dyslipidemia and the other one only with mild persistent asthma...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29164080/the-incidence-and-short-term-outcomes-of-acute-respiratory-illness-with-cough-in-children-from-a-socioeconomically-disadvantaged-urban-community-in-australia-a-community-based-prospective-cohort-study
#6
Kerry K Hall, Anne B Chang, Jennie Anderson, Daniel Arnold, Vikas Goyal, Melissa Dunbar, Michael Otim, Kerry-Ann F O'Grady
Background: Acute respiratory illnesses with cough (ARIwC) are predominant causes of morbidity in Australian Indigenous children; however, data on disease burden in urban communities are scarce. This study aimed to determine the incidence of ARIwC, the predictors of recurrent (≥4 episodes) ARIwC, and development of chronic cough following an ARIwC in urban, predominantly Indigenous, children aged <5 years from northern Brisbane, Australia. Methods: Prospective cohort study of children aged <5 years registered with a primary healthcare center...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29132121/the-therapeutic-potential-of-cftr-modulators-for-copd-and-other-airway-diseases
#7
REVIEW
George M Solomon, Lianwu Fu, Steven M Rowe, James F Collawn
Airways diseases, especially chronic obstructive pulmonary disease (COPD) and asthma, are common causes of morbidity and mortality worldwide. There is an ongoing unmet need for novel and effective therapies. There is an established pathophysiological link and phenotypic similarity between the chronic bronchitis phenotype of COPD and cystic fibrosis (CF). New evidence suggests that CFTR dysfunction may play a role in other common airways diseases such as COPD, non-atopic asthma and non-CF bronchiectasis. Newly approved and investigational drugs that target both mutant and wild-type CFTR channels have provided a new treatment opportunity addressing the mucus defect in pulmonary diseases that share the same pathophysiology with CF...
June 2017: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/29128130/spanish-guidelines-on-the-evaluation-and-diagnosis-of-bronchiectasis-in-adults
#8
Miguel Ángel Martínez-García, Luis Máiz, Casilda Olveira, Rosa María Girón, David de la Rosa, Marina Blanco, Rafael Cantón, Montserrat Vendrell, Eva Polverino, Javier de Gracia, Concepción Prados
In 2008, the Spanish Society of Pulmonology (SEPAR) published the first guidelines in the world on the diagnosis and treatment of bronchiectasis. Almost 10 years later, considerable scientific advances have been made in both the treatment and the evaluation and diagnosis of this disease, and the original guidelines have been updated to include the latest scientific knowledge on bronchiectasis. These new recommendations have been drafted following a strict methodological process designed to ensure the quality of content, and are linked to a large amount of online information that includes a wealth of references...
November 8, 2017: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/29069930/long-term-health-effects-of-chemical-warfare-agents-on-children-following-a-single-heavy-exposure
#9
J M Talabani, A I Ali, A M Kadir, R Rashid, F Samin, D Greenwood, Awm Hay
In the 1980s, villages in the Kurdistan region of Iraq were exposed to chemical weapons (CWs), which killed and injured thousands of civilians. There has been no clinical assessment of the long-term effects of CWs exposure on those injured. We report the first such evaluation of CW effects on long-term health of children. Patients from the CW-exposed areas were interviewed to assess previous and current clinical history and underwent clinical examination. The status of organs known to be targets of CWs, including skin, eyes, respiratory and neuromuscular systems, was assessed...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/29066918/asthma-with-bronchial-hypersecretion-expression-of-mucins-and-toll-like-receptors-in-sputum-and-blood
#10
Astrid Crespo-Lessmann, Eder Mateus, Montserrat Torrejón, Alicia Belda, Jordi Giner, Silvia Vidal, Oriol Sibila, Vicente Plaza
Asthma with bronchial hypersecretion is a type of asthma that is poorly studied. Its pathogenesis is not well understood, but is probably related to innate impaired immunity, particularly with toll-like receptors (TLRs) and secretory mucins (MUC). OBJECTIVES: 1) Define the clinical and inflammatory phenotype of asthma with bronchial hypersecretion of mucus. 2) Compare the type of mucin present in induced sputum (IS) of patients with and without bronchial hypersecretion. 3) Determine the expression of TLRs in IS and blood of asthmatics with and without bronchial hypersecretion...
2017: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/29035608/f508del-cftr-gene-mutation-in-patients-with-allergic-bronchopulmonary-aspergillosis
#11
Maria N Gamaletsou, Gemma Hayes, Chris Harris, Joanna Brock, Eavan G Muldoon, David W Denning
OBJECTIVE: The F508del mutation occurs in approximately 3.5% of Caucasian population of Northern Europe. Heterozygotes have increased risk for asthma and reduced pulmonary function. Allergic bronchopulmonary aspergillosis (ABPA) is more common in patients with cystic fibrosis (CF). We aimed to establish the frequency of F508del mutation in adult patients with ABPA. METHODS: A retrospective matched case-control study of CF genotyped patients with ABPA seen at the National Aspergillosis Centre was undertaken...
October 16, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28975014/the-relative-burden-of-menopausal-and-postmenopausal-symptoms-versus-other-major-conditions-a-retrospective-analysis-of-the-medical-expenditure-panel-survey-data
#12
Annlouise R Assaf, Andrew G Bushmakin, Nina Joyce, Michael J Louie, Michael Flores, Margaret Moffatt
BACKGROUND: The direct costs associated with menopausal and postmenopausal symptoms (hereafter "menopausal symptoms") may include the costs of physician and emergency department visits, medications, laboratory testing, and the management of side effects. However, much remains unknown about the costs related to menopausal symptoms, including how they compare with the costs of other diseases that are common among menopausal women. OBJECTIVE: To compare the economic burden of menopausal symptoms with other select prevalent chronic conditions among a nationally representative sample of US menopausal women aged 45 to 65 years...
September 2017: American Health & Drug Benefits
https://www.readbyqxmd.com/read/28956954/hiv-related-chronic-lung-disease-in-adolescents-are-we-prepared-for-the-future
#13
Pierre Goussard, Robert P Gie
Chronic lung diseases (CLD) are the most chronic disease occurring in adolescents living with human immunodeficiency virus (ALHIV). In ALHIV who received antiretroviral therapy (ART) late in childhood, bronchiectasis, bronchiolitis obliterans and interstitial pneumonitis are common. In adolescents who received ART early in life the spectrum of CLD has changed with asthma and chronic obstructive pulmonary disease being common. Areas covered: The aim of this paper was to review CLD in ALHIV. We conducted a literature review of electronic databases focusing on CLD that were common prior to the introduction of ART (1996-2004), the present situation where ART is widely available (2005 to 2016), and articles which aided us speculating on the impact of HIV-related CLD in adolescents transitioning to adult HIV-clinics...
December 2017: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/28894479/the-european-multicentre-bronchiectasis-audit-and-research-collaboration-embarc-experiences-from-a-successful-ers-clinical-research-collaboration
#14
REVIEW
James D Chalmers, Megan Crichton, Pieter C Goeminne, Michael R Loebinger, Charles Haworth, Marta Almagro, Montse Vendrell, Anthony De Soyza, Raja Dhar, Lucy Morgan, Francesco Blasi, Stefano Aliberti, Jeanette Boyd, Eva Polverino
In contrast to airway diseases like chronic obstructive pulmonary disease or asthma, and rare diseases such as cystic fibrosis, there has been little research and few clinical trials in bronchiectasis. Guidelines are primarily based on expert opinion and treatment is challenging because of the heterogeneous nature of the disease. In an effort to address decades of underinvestment in bronchiectasis research, education and clinical care, the European Multicentre Bronchiectasis Audit and Research Collaboration (EMBARC) was established in 2012 as a collaborative pan-European network to bring together bronchiectasis researchers...
September 2017: Breathe
https://www.readbyqxmd.com/read/28863927/the-role-of-non-invasive-modalities-for-assessing-inflammation-in-patients-with-non-cystic-fibrosis-bronchiectasis
#15
Stamatoula Tsikrika, Katerina Dimakou, Andriana I Papaioannou, Georgios Hillas, Loukas Thanos, Kostantinos Kostikas, Stelios Loukides, Spyros Papiris, Nickolaos Koulouris, Petros Bakakos
INTRODUCTION: Bronchiectasis is a heterogeneous entity, taking into account clinical characteristics, inflammatory response, effectiveness of treatment and frequency of exacerbations. In stable state non-cystic fibrosis (non-CF) bronchiectasis, little is known about non-invasive techniques used for evaluating airway inflammation in obstructive airway diseases. OBJECTIVES: We sought to evaluate the associations between induced sputum and clinical/radiologic characteristics, and the differences between biomarkers expressing Th1 and Th2 response in patients with non-CF bronchiectasis and to compare our findings with a previously studied population of patients with asthma and COPD...
August 29, 2017: Cytokine
https://www.readbyqxmd.com/read/28834349/extramedullary-plasmacytoma-in-the-airway-of-an-hiv-positive-child
#16
Pierre Goussard, Alexia Kappos, Jacques Janson
We describe a case of an extramedullary plasmacytoma (EMP) in an HIV-positive child. An 11- year-old, HIV-infected female patient, on antiretroviral therapy since 2010, was referred with difficult to control asthma and bronchiectasis. The lesion was identified on CT chest following persisting reduced air entry and unilateral wheezing on the right. Rigid bronchoscopy identified a large pedunculated fleshy mass in the right main bronchus. Biopsy revealed it to be a plasmacytoma. Right main bronchus sleeve resection was done with complete removal of the tumor...
August 18, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28814783/mycoplasma-pneumoniae-associated-bronchiolitis-obliterans-following-acute-bronchiolitis
#17
Chengsong Zhao, Jinrong Liu, Haiming Yang, Li Xiang, Shunying Zhao
The characteristics of Mycoplasma pneumonia (M. pneumoniae)-associated bronchiolitis obliterans (BO) are not well known. We retrospectively reviewed 17 patients with M. pneumoniae-associated BO. All patients had M. pneumoniae-associated acute bronchiolitis prior to the development of BO. In the acute bronchiolitis stage, all patients had fever and cough; six patients also had wheezing and dyspnoea. BO was diagnosed approximately 1.5-8 months later based on clinical manifestations and chest high-resolution computed tomography (HRCT) findings...
August 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28807087/allergic-bronchopulmonary-mycosis-due-to-exposure-to-eurotium-herbariorum-after-the-great-east-japan-earthquake
#18
Chiyako Oshikata, Maiko Watanabe, Akemi Saito, Masatsugu Ishida, Seiichi Kobayashi, Rumi Konuma, Yoichi Kamata, Jun Terajima, Junichi Cho, Masaru Yanai, Naomi Tsurikisawa
BACKGROUND: Indoor mold levels typically increase after natural disasters, flooding, and water damage. Eurotium herbariorum is the sexual stage of Aspergillus glaucus. Case Presentation A 66-year-old, Japanese male, ex-smoker had been diagnosed with bronchial asthma when he was five years old; he achieved remission at the age of 13 years. He was displaced from his home during the Great East Japan Earthquake on March 11, 2011 and moved to temporary housing in Miyagi Prefecture in June 2011...
August 15, 2017: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/28765819/a-review-of-42-asthmatic-children-with-allergic-bronchopulmonary-aspergillosis
#19
Ashok Shah, Shekhar Kunal
BACKGROUND: Allergic bronchopulmonary aspergillosis (ABPA) in children with asthma, not associated with cystic fibrosis, is yet to receive the recognition it deserves. OBJECTIVE: To highlight the presentation of ABPA in children with asthma. METHODS: This retrospective review documents the occurrence of pediatric ABPA over a period of 31 years in one unit. Children with asthma, eosinophilia and infiltrates on chest radiograph were screened for ABPA...
July 2017: Asia Pacific Allergy
https://www.readbyqxmd.com/read/28748310/long-term-outcome-of-adenosine-deaminase-deficient-patients-a-single-center-experience
#20
Ori Scott, Vy Hong-Diep Kim, Brenda Reid, Anne Pham-Huy, Adelle R Atkinson, Alessandro Aiuti, Eyal Grunebaum
PURPOSE: Inherited defects in the adenosine deaminase (ADA) enzyme can cause severe combined immune deficiency (SCID) and systemic abnormalities. Management options for ADA-deficient patients include enzyme replacement therapy (ERT), hematopoietic stem cell transplantation (HSCT), and gene therapy (GT). Here, we describe the long-term benefits of these treatments. METHODS: Survival, infections, systemic sequelae, and laboratory assessments were recorded for all ADA-deficient SCID patients, managed at a single center since 1985, who survived 5 or more years following treatment...
July 26, 2017: Journal of Clinical Immunology
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