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Artemisia annua

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https://www.readbyqxmd.com/read/27884407/-activity-of-artemisia-annua-infusions-on-epimastigotes-of-trypanosoma-cruzi
#1
Mariolga Berrizbeitia de Morgado, Yusmaris Cariaco Sifontes, José Imery Buiza, Pierre Lutgen
No abstract text is available yet for this article.
November 21, 2016: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/27867026/artemisinin-and-its-derivatives-in-treating-protozoan-infections-beyond-malaria
#2
REVIEW
Cecilia Shi Ni Loo, Nelson Siu Kei Lam, Deying Yu, Xin-Zhuan Su, Fangli Lu
Many parasitic protozoan diseases continue to rank among the world's greatest global health problems, which are also common among poor populations. Currently available drugs for treatment present drawbacks, urging the need for more effective, safer, and cheaper drugs. Artemisinin (ART) and its derivatives are some of the most important classes of antimalarial agents originally derived from Artemisia annua L. However, besides the outstanding antimalarial and antischistosomal activities, ART and its derivatives also possess activities against other parasitic protozoa...
November 17, 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27857535/effect-of-gaeddongssuk-artemisia-annua-l-powder-on-quality-and-shelf-stability-of-emulsion-sausages-during-refrigerated-storage
#3
Hyoung-Joo Ham, Geun-Ho Kang, Yun-Sang Choi, Tae-Jun Jeong, Ko-Eun Hwang, Cheon-Jei Kim
The objective of this study was to evaluate effects of Gaeddongssuk powder (GP) on quality characteristics and shelf stability of emulsion sausages during storage. Proximate composition properties showed no significant differences in all treatment (p>0.05). Control showed the highest cooking loss while the treatment with GP showed decreased cooking loss depending on increasing GP content (p<0.05). Apparent viscosity of batter was increased as the amount of GP increased, whereas hardness of emulsion sausages was decreased with increasing GP level...
October 31, 2016: Korean Journal for Food Science of Animal Resources
https://www.readbyqxmd.com/read/27813878/antimalarial-drugs-as-immune-modulators-new-mechanisms-for-old-drugs
#4
Jie An, Mark Minie, Tomikazu Sasaki, Joshua J Woodward, Keith B Elkon
The best known of the naturally occurring antimalarial compounds are quinine, extracted from cinchona bark, and artemisinin (qinghao), extracted from Artemisia annua in China. These and other derivatives are now chemically synthesized and remain the mainstay of therapy to treat malaria. The beneficial effects of several of the antimalarial drugs (AMDs) on clinical features of autoimmune disorders were discovered by chance during WorldWar II. In this review, we discuss the chemistry of AMDs and their mechanisms of action, emphasizing how they may impact multiple pathways of innate immunity...
October 21, 2016: Annual Review of Medicine
https://www.readbyqxmd.com/read/27806033/an-open-label-six-month-extension-study-to-investigate-the-safety-and-efficacy-of-an-extract-of-artemisia-annua-for-managing-pain-stiffness-and-functional-limitation-associated-with-osteoarthritis-of-the-hip-and-knee
#5
Sheena Hunt, Simon Stebbings, Debra McNamara
AIMS: This six-month single-centre open-label extension study, conducted at the University of Otago, Dunedin, follows from a previously published 12-week pilot double-blind randomised placebo-controlled study of dietary supplement, Arthrem® (ART) in patients with osteoarthritis (OA) of the hip or knee. The pilot double-blind study showed that treatment with ART 150 mg twice-daily was associated with clinically relevant pain reduction. The extension study aims were to assess longer-term safety and efficacy during six months' treatment following the pilot trial...
October 28, 2016: New Zealand Medical Journal
https://www.readbyqxmd.com/read/27781497/solvents-effects-on-crystallinity-and-dissolution-of-%C3%AE-artemether
#6
Jianghui Xu, Vikramjeet Singh, Xianzhen Yin, Parbeen Singh, Li Wu, Xiaonan Xu, Tao Guo, Lixin Sun, Shuangying Gui, Jiwen Zhang
β-artemether (ARM) is a widely used anti-malarial drug isolated from the Chinese antimalarial plant, Artemisia annua. The solvent effects on crystal habits and dissolution of ARM were thoroughly investigated and discussed herein. The ARM was recrystallized in nine different solvents of varied polarity, namely, methanol, ethanol, isopropanol, tetrahydrofuran, dichloromethane, trichloromethane, ethyl acetate, acetone and hexane by solvent evaporation method. The obtained crystals were morphologically characterized using scanning electron microscope (SEM)...
November 14, 2016: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/27773616/compartmentalized-metabolic-engineering-for-artemisinin-biosynthesis-and-effective-malaria-treatment-by-oral-delivery-of-plant-cells
#7
Karan Malhotra, Mayavan Subramaniyan, Khushboo Rawat, Md Kalamuddin, M Irfan Qureshi, Pawan Malhotra, Asif Mohmmed, Katrina Cornish, Henry Daniell, Shashi Kumar
Artemisinin is highly effective against drug-resistant malarial parasites, which affects nearly half of the global population and kills >500 000 people each year. The primary cost of artemisinin is the very expensive process used to extract and purify the drug from Artemisia annua. Elimination of this apparently unnecessary step will make this potent antimalarial drug affordable to the global population living in endemic regions. Here we reported the oral delivery of a non-protein drug artemisinin biosynthesized (∼0...
November 7, 2016: Molecular Plant
https://www.readbyqxmd.com/read/27773251/extraction-mechanism-of-ultrasound-assisted-extraction-and-its-effect-on-higher-yielding-and-purity-of-artemisinin-crystals-from-artemisia-annua-l-leaves
#8
Smain Chemat, Abdallah Aissa, Abdenour Boumechhour, Omar Arous, Hamid Ait-Amar
This study proposes an ultrasound-horn system for the extraction of a natural active compound "artemisinin" from Artemisia annua L. leaves as an alternative to hot maceration technique. Ultrasound leaching improves artemisinin recovery at all temperatures where only ten minutes is required to recover 70% (4.42mgg(-1)) compared to 60min of conventional hot leaching for the same yield. For instance, ultrasound treatment at 30°C produced a higher yield than the one obtained by conventional maceration at 40°C...
January 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/27726019/effects-of-oral-administration-of-whole-plants-of-artemisia-annua-on-ichthyophthirius-multifiliis-and-aeromonas-hydrophila-after-parasitism-by-i-multifiliis
#9
Zhibin Wu, Fei Ling, Chenguang Song, Weichao Chen, Gaoxue Wang
Since the use of malachite green was banned, it is desirable to search for alternative drug to control Ichthyophthirius multifiliis infection. Moreover, route of administration which is easy to implement and less stressful to fish is important to treat infection of fish with this parasite. It is also important to enhance protective effect against Aeromonas hydrophila infection after parasitism by I. multifiliis. The present study evaluated the protective effect of diet supplemented with Artemisia annua against I...
October 10, 2016: Parasitology Research
https://www.readbyqxmd.com/read/27721819/si-accumulation-in-artemisia-annua-glandular-trichomes-increases-artemisinin-concentration-but-does-not-interfere-in-the-impairment-of-toxoplasma-gondii-growth
#10
Cristina Rostkowska, Caroline M Mota, Taísa C Oliveira, Fernanda M Santiago, Lilian A Oliveira, Gaspar H Korndörfer, Regina M Q Lana, Monica L Rossi, Neusa L Nogueira, Xavier Simonnet, Tiago W P Mineo, Deise A O Silva, José R Mineo
Artemisia annua is used as a source of artemisinin, a potent therapeutic agent used for the treatment of infectious diseases, chiefly malaria. However, the low concentration (from 0.01 to 1.4% of dried leaf matter) of artemisinin in the plant obtained with the traditional cropping system makes it a relatively expensive drug, especially in developing countries. Considering that artemisinin and silicon (Si) are both stored in A. annua glandular trichomes, and that Si accumulation has never been investigated, this study aimed to look into Si effects on A...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27706602/characterization-and-comparison-of-transgenic-artemisia-annua-gyr-and-wild-type-non-gyr-plants-in-an-environmental-release-trial
#11
H Liu, G G Wu, J B Wang, X Wu, L Bai, W Jiang, B B Lv, A H Pan, J W Jia, P Li, K Zhao, L X Jiang, X M Tang
The anti-malarial drug, artemisinin, is quite expensive as a result of its slow content in Artemisia annua. Recent investigations have suggested that genetic engineering of A. annua is a promising approach to improve the yield of artemisinin. In this study, the transgenic A. annua strain GYR, which has high artemisinin content, was evaluated in an environmental release trial. First, GYR plants were compared with the wild-type variety NON-GYR, with regard to phenotypic characters (plant height, crown width, stem diameter, germination rate, leaf dry weight, 1000-seed weight, leave shape)...
August 26, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27698485/applying-high-resolution-melting-hrm-technology-to-identify-five-commonly-used-artemisia-species
#12
Ming Song, Jingjian Li, Chao Xiong, Hexia Liu, Junsong Liang
Many members of the genus Artemisia are important for medicinal purposes with multiple pharmacological properties. Often, these herbal plants sold on the markets are in processed forms so it is difficult to authenticate. Routine testing and identification of these herbal materials should be performed to ensure that the raw materials used in pharmaceutical products are suitable for their intended use. In this study, five commonly used Artemisia species included Artemisia argyi, Artemisia annua, Artemisia lavandulaefolia, Artemisia indica, and Artemisia atrovirens were analyzed using high resolution melting (HRM) analysis based on the internal transcribed spacer 2 (ITS2) sequences...
October 4, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27659595/homeodomain-protein-1-is-required-for-jasmonate-mediated-glandular-trichome-initiation-in-artemisia-annua
#13
Tingxiang Yan, Minghui Chen, Qian Shen, Ling Li, Xueqing Fu, Qifang Pan, Yueli Tang, Pu Shi, Zongyou Lv, Weimin Jiang, Ya-Nan Ma, Xiaolong Hao, Xiaofen Sun, Kexuan Tang
Glandular trichomes are generally considered biofactories that produce valuable chemicals. Increasing glandular trichome density is a very suitable way to improve the productivity of these valuable metabolites, but little is known about the regulation of glandular trichome formation. Phytohormone jasmonate (JA) promotes glandular trichome initiation in various plants, but its mechanism is also unknown. By searching transcription factors regulated by JA in Artemisia annua, we identified a novel homeodomain-leucine zipper transcription factor, HOMEODOMAIN PROTEIN 1 (AaHD1), which positively controls both glandular and nonglandular trichome initiations...
September 23, 2016: New Phytologist
https://www.readbyqxmd.com/read/27652098/anti-inflammatory-and-acetylcholinesterase-activity-of-extract-fractions-and-five-compounds-isolated-from-the-leaves-and-twigs-of-artemisia-annua-growing-in-cameroon
#14
Rosine D K Chougouo, Yves M M Nguekeu, Jean P Dzoyem, Maurice D Awouafack, Jonas Kouamouo, Pierre Tane, Lyndy J McGaw, Jacobus N Eloff
BACKGROUND: Natural products, including those derived from higher plants have, over the years, contributed greatly to the development of modern therapeutic drugs. Due to the medicinal importance in traditional practice and the diversified biology and chemistry of the constituents from Artemisia spp., the genus has been receiving growing attention. The aim of this study was to investigate the ability of the ethanol extract, four fractions (F1-F4) and five compounds namely artemisinin (1), scopoletin (2), chrysosplenetin (3), eupatin (4) and 3-O-β-d-glucopyranoside of sitosterol (5) isolated from A...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27610371/corrigendum-to-type-2c-phosphatase-1-of-artemisia-annua-l-is-a-negative-regulator-of-aba-signaling
#15
Fangyuan Zhang, Xueqing Fu, Zongyou Lv, Qian Shen, Tingxian Yan, Weimin Jiang, Guofeng Wang, Xiaofen Sun, Kexuan Tang
[This corrects the article DOI: 10.1155/2014/521794.].
2016: BioMed Research International
https://www.readbyqxmd.com/read/27608659/evaluation-of-enzymatically-treated-artemisia-annua-l-on-growth-performance-meat-quality-and-oxidative-stability-of-breast-and-thigh-muscles-in-broilers
#16
X L Wan, Z H Song, Y Niu, K Cheng, J F Zhang, H Ahmad, L L Zhang, T Wang
An experiment was conducted to evaluate the effects of including enzymatically treated Artemisia annua L. (EA) in broiler diets on growth performance, meat quality, and oxidative stability of breast and thigh muscles. A total of 256 one-d-old Arbor Acres broiler chicks were randomly allotted into four groups with eight replicates of eight birds each. Broilers in the four groups were offered basal diet supplemented with 0.0, 0.5, 1.0, and 1.5 g/kg EA during the 42-d experiment, respectively. The ADG, ADFI, and feed/gain ratio (F:G) were measured at 42 d of age...
September 8, 2016: Poultry Science
https://www.readbyqxmd.com/read/27607516/evaluation-of-dna-barcode-candidates-for-the-discrimination-of-artemisia-l
#17
Geyu Liu, Huixia Ning, Nurbolati Ayidaerhan, Haji Akber Aisa
Because of the very similar morphologies and wide diversity of Artemisia L. varieties, they are difficult to identify, and there have been many arguments about the systematic classification Artemisia L., especially concerning the division of species. DNA barcode technology is used to rapidly identify species based on standard short DNA sequences. To evaluate seven candidate DNA barcodes (ITS, ITS2, psbA-trnH, rbcL, matK, rpoB, and rpoC1) regarding their ability to identify closely related species of the Artemisia genus in Xinjiang...
September 8, 2016: Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis
https://www.readbyqxmd.com/read/27590023/pharmacokinetics-and-disposition-of-circulating-iridoids-and-organic-acids-in-rats-intravenously-receiving-reduning-injection
#18
Chen Cheng, Feifei Du, Ke Yu, Fang Xu, Fengqing Wang, Li Li, Olajide E Olaleye, Junling Yang, Feng Chen, Chenchun Zhong, Qiongwei Liu, Jing Li, Zhenzhong Wang, Chuan Li, Wei Xiao
ReDuNing injection, prepared from a combination of Gardenia Jasminoides fruits, Lonicera japonica flower buds, and the Artemisia annua aerial part, is extensively used for treatment of viral upper respiratory tract infections in China. Iridoids, organic acids, and flavonoids are likely important compounds of the herbal injection because of their reported pharmacological properties. This study was designed to characterize pharmacokinetics and disposition of the major circulating herbal compounds in rats that received the injection intravenously...
November 2016: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/27582332/dna-barcode-for-identifying-folium-artemisiae-argyi-from-counterfeits
#19
Quanxi Mei, Xiaolu Chen, Li Xiang, Yue Liu, Yanyan Su, Yuqiao Gao, Weibo Dai, Pengpeng Dong, Shilin Chen
Folium Artemisiae Argyi is an important herb in traditional Chinese medicine. It is commonly used in moxibustion, medicine, etc. However, identifying Artemisia argyi is difficult because this herb exhibits similar morphological characteristics to closely related species and counterfeits. To verify the applicability of DNA barcoding, ITS2 and psbA-trnH were used to identify A. argyi from 15 closely related species and counterfeits. Results indicated that total DNA was easily extracted from all the samples and that both ITS2 and psbA-trnH fragments can be easily amplified...
2016: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27565777/cumulative-role-of-bioinoculants-on-growth-antioxidant-potential-and-artemisinin-content-in-artemisia-annua-l-under-organic-field-conditions
#20
Rupali Gupta, Akanksha Singh, M M Gupta, Rakesh Pandey
Artemisia annua L. is mostly known for a bioactive metabolite, artemisinin, an effective sesquiterpene lactone used against malaria without any reputed cases of resistance. In this experiment, bioinoculants viz., Streptomyces sp. MTN14, Bacillus megaterium MTN2RP and Trichoderma harzianum Thu were applied as growth promoting substances to exploit full genetic potential of crops in terms of growth, yield, nutrient uptake and particularly artemisinin content. Further, multi-use of the bioinoculants singly and in combinations for the enhancement of antioxidant potential and therapeutic value was also undertaken which to our knowledge has never been investigated in context with microbial application...
October 2016: World Journal of Microbiology & Biotechnology
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