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Artemisia annua

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https://www.readbyqxmd.com/read/29332277/efficient-degradation-of-triclosan-by-an-endophytic-fungus-penicillium-oxalicum-b4
#1
Hao Tian, Yan Jun Ma, Wan Yi Li, Jian Wen Wang
Triclosan (TCS), a widely used antimicrobial and preservative agent, is an emerging contaminant in aqueous and soil environment. Microbial degradation of TCS has not been reported frequently because of its inhibition of microbe growth. To explore the new microbial resources for TCS biodegradation, fungal endophytes were isolated and screened for the degradation potential. The endophytic strain B4 isolated from Artemisia annua L. showed higher degradation efficiency and was identified as Penicillium oxalicum based on its morphology and ITS sequences of ribosomal DNA...
January 13, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29318820/-detection-and-analysis-of-effect-of-geographical-environmental-factors-on-spatial-distribution-of-artemisinic-acid-in-artemisia-annua
#2
Ting-Ting Shi, Xiao-Bo Zhang, Lan-Ping Guo, Hui Wang, Zhi-Xian Jing, Lu-Qi Huang
Dao-di herbs are preferred by long-term clinical application of Chinese medicine, they are produced in a specific area and affected by the specific production and processing methods. Dao-di herbs have a high reputation, compared with other regions produced by the same kind of herbs with good quality, good efficacy and stable quality characteristics. Geo-herbal is a unique concept that has been formed by the history of Chinese civilization for thousands of years and the history of Chinese medicine. According to the definition of geo-herbal, it can be seen that there are some differences in the quality and efficacy of the same kind of medicinal herbs in different regions, and there is some similarity in the specific area...
November 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29318819/-analysis-of-spatial-distribution-of-artemisinin-in-artemisia-annua-in-china
#3
Xiao-Bo Zhang, Lan-Ping Guo, Zhi-Dong Qiu, Xiao-Bo Qu, Hui Wang, Zhi-Xian Jing, Lu-Qi Huang
Geo-herbals are preferred by long-term clinical application of Chinese medicine, they are produced in a specific area and affected by the specific production and processing methods. Geo-herbals have a high reputation, compared with other regions produced by the same kind of herbs with good quality, efficacy and stable quality characteristics. Geo-herbal is a unique concept that has been formed by the history of Chinese civilization for thousands of years and the history of Chinese medicine. According to the definition of geo-herbal, it can be seen that there are some differences in the quality and efficacy of the same kind of medicinal herbs in different regions, and there is some similarity in the specific area...
November 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29317241/influence-of-artemisia-annua-l-on-toll-like-receptor-expression-in-brain-of-mice-infected-with-acanthamoeba-sp
#4
Agnieszka Wojtkowiak-Giera, Monika Derda, Danuta Kosik-Bogacka, Agnieszka Kolasa-Wołosiuk, Piotr Solarczyk, Marcin Cholewiński, Elżbieta Wandurska-Nowak, Paweł P Jagodziński, Edward Hadaś
The treatment of acanthamoebiasis is a still a problem. Our previous studies showed that the application of extracts from Artemisia annua L. significantly prolonged the survival of mice infected by Acanthamoeba. This plant has medicinal properties in the treatment of human parasitic diseases. The aim of this study was to evaluate the effects of A. annua on expression of Toll-like receptors (TLRs) 2 and 4 in brain of mice with Acanthamoeba infection. Mice were infected with Acanthamoeba sp. strain Ac309 (KY203908) by intranasal inoculation without and after application of A...
January 6, 2018: Experimental Parasitology
https://www.readbyqxmd.com/read/29315586/dietary-enzymatically-treated-artemisia-annua-l-improves-meat-quality-antioxidant-capacity-and-energy-status-of-breast-muscle-in-heat-stressed-broilers
#5
Xiaoli Wan, Hussain Ahmad, Lili Zhang, Zhiyue Wang, Tian Wang
BACKGROUND: Heat stress (HS) is detrimental to animal origin food production. Artemisia annua L., a natural source of phenolic compounds and flavonoids, exhibits antioxidant property. This study was conducted to evaluate the effects of dietary enzymatically treated Artemisia annua L. (EA) supplementation on meat quality, antioxidant capacity and energy status of breast muscle in heat-stressed broilers. RESULTS: The EA inclusion increased the redness value, reduced drip loss, decreased reactive oxygen metabolites and thiobarbituric acid-reactive substances, increased antioxidant enzyme activities, and reduced the ferric reducing antioxidant power and free radical scavenging abilities of breast muscle in heat-treated broilers...
January 9, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29301383/increasing-the-strength-and-production-of-artemisinin-and-its-derivatives
#6
REVIEW
Syed Lal Badshah, Asad Ullah, Nasir Ahmad, Zainab M Almarhoon, Yahia Mabkhot
Artemisinin is a natural sesquiterpene lactone obtained from the Artemisia annua herb. It is widely used for the treatment of malaria. In this article, we have reviewed the role of artemisinin in controlling malaria, spread of resistance to artemisinin and the different methods used for its large scale production. The highest amount of artemisinin gene expression in tobacco leaf chloroplast leads to the production of 0.8 mg/g of the dry weight of the plant. This will revolutionize the treatment and control of malaria in third world countries...
January 3, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29301032/artemisinin-biosynthesis-promoting-kinase-1-positively-regulates-artemisinin-biosynthesis-through-phosphorylating-aabzip1
#7
Fangyuan Zhang, Lien Xiang, Qin Yu, Haoxing Zhang, Taixin Zhang, Junlan Zeng, Chen Geng, Ling Li, Xueqing Fu, Qian Shen, Chunxian Yang, Xiaozhong Lan, Min Chen, Kexuan Tang, Zhihua Liao
The plant Artemisia annua produces the anti-malarial compound artemisinin. Although the transcriptional regulation of artemisinin biosynthesis has been extensively studied, its post-translational regulatory mechanisms, especially that of protein phosphorylation, remain unknown. Here, we report that an ABA-responsive kinase (AaAPK1), a member of the SnRK2 family, is involved in regulating artemisinin biosynthesis. The physical interaction of AaAPK1 with AabZIP1 was confirmed by multiple assays, including yeast two-hybrid, bimolecular fluorescence complementation, and pull-down...
December 28, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29300490/dimeric-cadinane-sesquiterpenoid-derivatives-from-artemisia-annua
#8
Da-Peng Qin, Da-Bo Pan, Wei Xiao, Hai-Bo Li, Biao Yang, Xiao-Jun Yao, Yi Dai, Yang Yu, Xin-Sheng Yao
Arteannoide A (1), an unusual cadinane dimer featuring a rare fused 6,8-dioxabicyclo[3.2.l]octan-7-one ring system, arteannoides B and C (2 and 3), two novel heterodimers incorporating a rearranged cadinene sesquiterpenoid and a phenylpropanoid, together with two new rearranged cadinene sesquiterpenoids 4 and 5, were isolated from Artemisia annua L. Their structures were determined by a combination of NMR spectroscopy, electronic circular dichroism calculations, and X-ray diffraction analyses. Compounds 2 and 3 showed inhibition of nitric oxide production in lipopolysaccharide-induced RAW 264...
January 4, 2018: Organic Letters
https://www.readbyqxmd.com/read/29259649/chloroform-extract-of-artemisia-annua-l-relaxes-mouse-airway-smooth-muscle
#9
Jun Huang, Li-Qun Ma, Yongle Yang, Nana Wen, Wan Zhou, Congli Cai, Qing-Hua Liu, Jinhua Shen
Artemisia annua L. belongs to the Asteraceae family, which is indigenous to China. It has valuable pharmacological properties, such as antimalarial, anti-inflammatory, and anticancer properties. However, whether it possesses antiasthma properties is unknown. In the current study, chloroform extract of Artemisia annua L. (CEAA) was prepared, and we found that CEAA completely eliminated acetylcholine (ACh) or high K+-elicited (80 mM) contractions of mouse tracheal rings (TRs). Patch-clamp technique and ion channel blockers were employed to explore the underlying mechanisms of the relaxant effect of CEAA...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29258280/four-new-compounds-obtained-from-cultured-cells-of-artemisia-annua
#10
Jianhua Zhu, Peijie Xiao, Minghua Qian, Chang Chen, Chuxin Liang, Jiachen Zi, Rongmin Yu
Four new compounds obtained from cultured cells of Artemisia annua were reported. Products were detected by HPLC-ELSD/GC-MS and isolated by chromatographic methods. The structures of four new compounds, namely 6-hydroxy arteannuin I (1), 1-hydroxy arteannuin I (2), 2-hydroxy arteannuin J (3), and 14-hydroxy arteannuin J (4), were elucidated using their physico-chemical properties by NMR and MS data analyses. The results from the spontaneous oxidative experiment indicated that the biosynthesis of the new compounds was enzyme-catalyzed...
December 18, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29230013/artemisia-annua-extract-prevents-ovariectomy-induced-bone-loss-by-blocking-receptor-activator-of-nuclear-factor-kappa-b-ligand-induced-differentiation-of-osteoclasts
#11
Sun Kyoung Lee, Hyungkeun Kim, Junhee Park, Hyun-Jeong Kim, Ki Rim Kim, Seung Hwa Son, Kwang-Kyun Park, Won-Yoon Chung
The activities of osteoclasts and osteoblasts are balanced to maintain normal bone density. Many pathological conditions cause osteoclastic bone resorption in excess of osteoblastic bone formation, resulting in osteoporosis. We found that oral administration of Artemisia annua ethanol extract (AaE) or major components, artemisinin and arteannuin B, to ovariectomized (OVX) mice prevented bone loss, as verified by examining three-dimensional images and bone morphometric parameters derived from microcomputed tomography analysis, as well as serum levels of bone turnover markers and proinflammatory cytokines...
December 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29220102/identification-of-a-62-kda-major-allergen-from-artemisia-pollen-as-a-putative-galactose-oxidase
#12
Wanyi Fu, Zhongshan Gao, Ling Gao, Jing Jin, Meiling Liu, Yuemei Sun, Shandong Wu, Lingying Wu, Hongshan Ma, Yimin Dong, Xuefeng Wang, Biyuan Gao, Huiying Wang, Jaap H Akkerdaas, Serge A Versteeg, Ronald van Ree
BACKGROUND: Around 20 years ago, a 60-70 kDa protein was reported as a major allergen of mugwort (Artemisia vulgaris) pollen. This study was to identify and characterize its molecular properties. METHODS: Sera from 113 Chinese and 20 Dutch Artemisia allergic/sensitized subjects (and pools thereof) were used to identify the 60-70 kDa allergen. Pollen extracts of seven Artemisia species were compared by immunoblotting. Transcriptomics and proteomics (mass spectrometry) of A...
December 8, 2017: Allergy
https://www.readbyqxmd.com/read/29187859/a-review-of-biotechnological-artemisinin-production-in-plants
#13
REVIEW
Nur K B K Ikram, Henrik T Simonsen
Malaria is still an eminent threat to major parts of the world population mainly in sub-Saharan Africa. Researchers around the world continuously seek novel solutions to either eliminate or treat the disease. Artemisinin, isolated from the Chinese medicinal herb Artemisia annua, is the active ingredient in artemisinin-based combination therapies used to treat the disease. However, naturally artemisinin is produced in small quantities, which leads to a shortage of global supply. Due to its complex structure, it is difficult chemically synthesize...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29077887/effects-of-dietary-supplementation-with-enzymatically-treated-artemisia-annua-on-growth-performance-intestinal-morphology-digestive-enzyme-activities-immunity-and-antioxidant-capacity-of-heat-stressed-broilers
#14
Z H Song, K Cheng, X C Zheng, H Ahmad, L L Zhang, T Wang
The gastrointestinal tract is considered as one of the main target organs affected by heat stress. Phytogenic feed additives containing phenolics and flavonoids can improve the resistance of broilers to heat stress. This study was conducted to investigate the effects of dietary supplementation with enzymatically treated Artemisia annua (EA) on growth performance, intestinal morphology, digestive enzyme activities, immunity and antioxidant capacity of broilers challenged with heat stress. One hundred and forty-four 21-day-old male Arbor Acres broilers were randomly distributed into 3 treatments: 1) non-challenged control (CON); 2) heat-stress-challenged control (HS); and 3) heat-stress-challenged group + 1 g EA/kg diet (HS-EA)...
October 25, 2017: Poultry Science
https://www.readbyqxmd.com/read/29062278/artemisinin-derivatives-target-topoisomerase-1-and-cause-dna-damage-in-silico-and-in-vitro
#15
Onat Kadioglu, Ariel Chan, Alena Cong Ling Qiu, Vincent Kam Wai Wong, Vanessa Colligs, Sabine Wecklein, Halima Freund-Henni Rached, Thomas Efferth, Wen-Luan Wendy Hsiao
DNA topoisomerases 1 and 2 are enzymes that maintain DNA topology and play important essential genome functions, including DNA replication and transcription. Aberrant topoisomerases cause genome instability and a wide range of diseases, cancer in particular. Both Topo 1 and 2 are the targets of valuable anticancer drugs, such as camptothecin. It has been previously shown that artemisinin, a sesquiterpene lactone from Artemisia annua L. also known as qinghaosu, possesses anti-cancer effects and one of its derivatives, artesunate inhibits Topo 2...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29061778/anticancer-activity-of-artemisinin-and-its-derivatives
#16
REVIEW
Silvia Slezakova, Jana Ruda-Kucerova
Artemisinin is an extract from the plant Artemisia annua. With its semi-synthetic derivatives, they form a group of well-known and efficacious antimalarial drugs. Recent studies have documented the potential anticancer effect of artemisinin and its derivatives (ARTs). This review summarizes results of preclinical studies, documenting mechanisms of anticancer actions of ARTs and clinical studies focused mainly on efficacy, safety and dose-ranging of ARTs as anticancer chemotherapeutics. The main mechanisms of action of ARTs is the production of reactive oxygen species, inhibition of cell cycle in G0/G1 phase, induction of apoptosis and inhibition of angiogenesis...
November 2017: Anticancer Research
https://www.readbyqxmd.com/read/29052405/-its2-sequence-analysis-and-identification-of-medicinal-artemisia-plants
#17
Yao-Yao Ren, Nan-Ping Jiang, Rui-Ying Liu, Liang-Ke Song, Rui Tan, Jian Gu
Artemisia hedinii occupies an important position in the Tibetan medicine. Plants in Artemisia vary a lot and are widely distributed in the Qinghai-Tibet Plateau, many plants in Artemisia look similar, making traditional identification methods laborious. In this article, ITS2 sequences were used as DNA barcoding to identify four kinds of confusable Tibetan medicine plants in Artemisia, aiming to establish a rapid and accurate identification methods. Twenty-one samples in Artemisia were collected from the Qinghai-Tibet Plateau, ITS2 sequence PCR amplification and sequencing were conducted after the extraction of DNA...
April 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29037381/dietary-supplementation-of-enzymatically-treated-artemisia-annua-could-alleviate-the-intestinal-inflammatory-response-in-heat-stressed-broilers
#18
Zhihua Song, Kang Cheng, Lili Zhang, Tian Wang
The study was undertaken to evaluate the effects of enzymatically treated Artemisia annua (EA) on the intestinal inflammatory response of heat-stressed broilers. A total of 144 male Arbor Acres broilers aged 21 days were randomly divided into 3 groups with 6 replicates per group and 8 broilers in each replicate. The 3 treatment groups were as follows: the control group, in which broiler chickens were raised at 22 ± 1°C and fed basal diets, the heat stress (HS) and HS-EA groups, in which broiler chickens were raised at 34 ± 1°C for 8h (0900-1700h) and 22 ± 1°C for 16h, and fed basal diets supplemented with 0 or 1g/kg EA, respectively...
October 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/28945019/-molecular-mechanism-of-artemisinin-biosynthesis-and-regulation-in-artemisia-annua
#19
REVIEW
He-Xin Tan, Ling Xiao, Zheng Zhou, Lei Zhang, Wan-Sheng Chen
Artemisinin-based combination therapy (ACT) is the best available treatment, particularly for Plasmodium falciparum malaria. Artemisinin, whose main source is Artemisia annua, has large demand and shortsupply every year.Artemisininis synthesized,stored, and secreted by the glandular secretory trichomes of A. annua(AaGSTs).In general, the population and morphology of AaGSTs are often positively correlated with artemisinin content.This review article introduces the molecular mechanism of biosynthesis and regulation of artemisininin A...
January 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28940606/the-roles-of-aamixta1-in-regulating-the-initiation-of-glandular-trichomes-and-cuticle-biosynthesis-in-artemisia-annua
#20
Pu Shi, Xueqing Fu, Qian Shen, Meng Liu, Qifang Pan, Yueli Tang, Weimin Jiang, Zongyou Lv, Tingxiang Yan, Yanan Ma, Minghui Chen, Xiaolong Hao, Pin Liu, Ling Li, Xiaofen Sun, Kexuan Tang
The glandular secretory trichomes (GSTs) on Artemisia annua leaves have the capacity to secrete and store artemisinin, a compound which is the most effective treatment for uncomplicated malaria. An effective strategy to improve artemisinin content is therefore to increase the density of GSTs in A. annua. However, the formation mechanism of GSTs remains poorly understood. To explore the mechanisms of GST initiation in A. annua, we screened myeloblastosis (MYB) transcription factor genes from a GST transcriptome database and identified a MIXTA transcription factor, AaMIXTA1, which is expressed predominantly in the basal cells of GST in A...
September 20, 2017: New Phytologist
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