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Artemisia annua

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https://www.readbyqxmd.com/read/28209917/artesunate-suppresses-the-viability-and-mobility-of-prostate-cancer-cells-through-uca1-the-sponge-of-mir-184
#1
Yan Zhou, Xiuju Wang, Jianjun Zhang, Aina He, Ya Ling Wang, Kun Han, Yang Su, Junyi Yin, Xiaobin Lv, Haiyan Hu
Artesunate (ART) is a sesquiterpene lactone isolated from the leafy portions of the Chinese herb Artemisia annua. Here, we evaluated the effect of ART on the prostate cancer (PCa) cell lines DU145 and LNCaP and explored its potential mechanisms. ART inhibited the viability and mobility of DU145 and LNCaP cells. Mechanistically, we found that UCA1, one of the most important lncRNAs in malignancies of the urinary system, may be a potential mediator contributing to the tumor suppressor function of ART. First, the UCA1 level was reduced significantly after being exposed to ART...
February 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28207974/aamyb1-and-its-orthologue-atmyb61-affect-terpene-metabolism-and-trichome-development-in-artemisia-annua-and-arabidopsis-thaliana
#2
Luis Matías-Hernández, Weimin Jiang, Ke Yang, Kexuan Tang, Peter E Brodelius, Soraya Pelaz
The effective anti-malarial drug artemisinin (AN) isolated from Artemisia annua is relatively expensive due to the low content in the plant as it is only synthesized within the glandular trichomes. Therefore, genetic engineering of A. annua is one of the most promising approaches to improve AN yield. In this work, AaMYB1 transcription factor has been identified and characterized. When AaMYB1 is overexpressed in A. annua, either exclusively in trichomes or in the whole plant, essential AN biosynthetic genes are also overexpressed and consequently AN amount significantly increased...
February 16, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28197158/overexpression-and-suppression-of-artemisia-annua-4-hydroxy-3-methylbut-2-enyl-diphosphate-reductase-1-gene-aahdr1-differentially-regulate-artemisinin-and-terpenoid-biosynthesis
#3
Dongming Ma, Gui Li, Yue Zhu, De-Yu Xie
4-Hydroxy-3-methylbut-2-enyl diphosphate reductase (HDR) catalyzes the last step of the 2-C-methyl-D-erythritol 4- phosphate (MEP) pathway to synthesize isopentenyl pyrophosphate (IPP) and dimethylallyl diphosphate (DMAPP). To date, little is known regarding effects of an increase or a decrease of a HDR expression on terpenoid and other metabolite profiles in plants. In our study, an Artemisia annua HDR cDNA (namely AaHDR1) was cloned from leaves. Expression profiling showed that it was highly expressed in leaves, roots, stems, and flowers with different levels...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28193253/artemisia-spp-essential-oils-against-the-disease-carrying-blowfly-calliphora-vomitoria
#4
Stefano Bedini, Guido Flamini, Francesca Cosci, Roberta Ascrizzi, Maria Cristina Echeverria, Lucia Guidi, Marco Landi, Andrea Lucchi, Barbara Conti
BACKGROUND: Synanthropic flies play a considerable role in the transmission of pathogenic and non-pathogenic microorganisms. In this work, the essential oil (EO) of two aromatic plants, Artemisia annua and Artemisia dracunculus, were evaluated for their abilities to control the blowfly Calliphora vomitoria. Artemisia annua and A. dracunculus EOs were extracted, analysed and tested in laboratory bioassays. Besides, the physiology of EOs toxicity and the EOs antibacterial and antifungal properties were evaluated...
February 13, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28115979/application-of-3d-printing-to-prototype-and-develop-novel-plant-tissue-culture-systems
#5
Mukund R Shukla, Amritpal S Singh, Kevin Piunno, Praveen K Saxena, A Maxwell P Jones
BACKGROUND: Due to the complex process of designing and manufacturing new plant tissue culture vessels through conventional means there have been limited efforts to innovate improved designs. Further, development and availability of low cost, energy efficient LEDs of various spectra has made it a promising light source for plant growth in controlled environments. However, direct replacement of conventional lighting sources with LEDs does not address problems with uniformity, spectral control, or the challenges in conducting statistically valid experiments to assess the effects of light...
2017: Plant Methods
https://www.readbyqxmd.com/read/28052518/effects-of-enzymatically-treated-artemisia-annua-l-on-growth-performance-and-some-blood-parameters-of-broilers-exposed-to-heat-stress
#6
Xiaoli Wan, Luyi Jiang, Haoran Zhong, Yufang Lu, Lili Zhang, Tian Wang
To evaluate the effects of enzymatically treated Artemisia annua L. (EA) on growth performance and some blood parameters of broilers exposed to heat stress (HS), 320 22-day-old Arbor Acres male broilers were randomly allotted into five groups with eight replicates of eight birds each. Broilers in the control group were housed at 22 ± 1°C and fed the basal diet. Broilers in the HS, HS-EA0.75 , HS-EA1.00 and HS-EA1.25 groups were reared under HS (34 ± 1°C for 8 h/day and 22 ± 1°C for 16 h/day), and fed basal diet with 0, 0...
January 4, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28049347/strategies-to-enhance-biologically-active-secondary-metabolites-in-cell-cultures-of-artemisia-current-trends
#7
Mohammad Ali, Bilal Haider Abbasi, Nisar Ahmad, Haji Khan, Gul Shad Ali
The genus Artemisia has been utilized worldwide due to its immense potential for protection against various diseases, especially malaria. Artemisia absinthium, previously renowned for its utilization in the popular beverage absinthe, is gaining resurgence due to its extensive pharmacological activities. Like A. annua, this species exhibits strong biological activities like antimalarial, anticancer and antioxidant. Although artemisinin was found to be the major metabolite for its antimalarial effects, several flavonoids and terpenoids are considered to possess biological activities when used alone and also to synergistically boost the bioavailability of artemisinin...
January 3, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/28035541/effect-of-artemisia-annua-extract-on-treating-active-rheumatoid-arthritis-a-randomized-controlled-trial
#8
Min Yang, Ming-Yang Guo, Yong Luo, Ming-Dong Yun, Jiao Yan, Tao Liu, Chang-Hong Xiao
OBJECTIVE: To investigate the effect and safety of the complementary use of the extract of Artemisia annua L. (EAA) on treating active rheumatoid arthritis (RA). METHODS: A randomized controlled clinical trial was performed. All the 159 participates with active RA were randomly assigned to the control group (80 cases) and EAA group (79 cases). In the control group, patients were medicated with leflflunomide and methotrexate for 48 weeks; and patients in the EAA group were administrated with leflflunomide, methotrexate plus EAA (30 g/d)...
December 29, 2016: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28001315/glandular-trichome-specific-wrky-1-promotes-artemisinin-biosynthesis-in-artemisia-annua
#9
Minghui Chen, Tingxiang Yan, Qian Shen, Xu Lu, Qifang Pan, Youran Huang, Yueli Tang, Xueqing Fu, Meng Liu, Weimin Jiang, Zongyou Lv, Pu Shi, Ya-Nan Ma, Xiaolong Hao, Lida Zhang, Ling Li, Kexuan Tang
Artemisinin is a type of sesquiterpene lactone well known as an antimalarial drug, and is specifically produced in glandular trichomes of Artemisia annua. However, the regulatory network for the artemisinin biosynthetic pathway remains poorly understood. Exploration of trichome-specific transcription factors would facilitate the elucidation of regulatory mechanism of artemisinin biosynthesis. The WRKY transcription factor GLANDULAR TRICHOME-SPECIFIC WRKY 1 (AaGSW1) was cloned and analysed in A. annua. AaGSW1 exhibited similar expression patterns to the trichome-specific genes of the artemisinin biosynthetic pathway and AP2/ERF transcription factor AaORA...
December 21, 2016: New Phytologist
https://www.readbyqxmd.com/read/28000518/artemisinin-inhibits-inflammatory-response-via-regulating-nf-%C3%AE%C2%BAb-and-mapk-signaling-pathways
#10
Ke Si Wang, Junbo Li, Zhe Wang, Chunliu Mi, Juan Ma, Lian Xun Piao, Guang Hua Xu, Xuezheng Li, Xuejun Jin
Artemisinin, isolated from the Chinese plant Artemisia annua, has been used for many years to treat different forms of malarial parasites. In this study, we explored the anti-inflammatory activity of artemisinin and the underlying mechanism of this action. We demonstrated that the anti-inflammatory effects of artemisinin in TPA-induced skin inflammation in mice. Then the artemisinin significantly inhibited the expression of NF-κB reporter gene induced by TNF-α in a dose-dependent manner. Artemisinin also inhibited TNF-α induced phosphorylation and degradation of IκBα, p65 nuclear translocation...
December 21, 2016: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/27976219/development-of-membrane-by-electrospinning-containing-semi-synthetic-derivatives-of-artemisia-annua-linnaeus
#11
F V Zanutto, Jdpm Segundo, Thc Salles, L Servat-Medina, I M Oliveira Sousa, M Chorilli, M A d'Ávila, M A Foglio
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27976017/role-of-impurities-in-purification-of-artemisinin-from-artemisia-annua-extracts
#12
C Malwade, H Qu, B G Rong, L P Christensen
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27975985/artemisia-annua-cell-cultures-as-tools-for-investigating-the-production-of-bioactive-compounds
#13
S Caretto, F Rizzello, M Durante, M S Lenucci, A De Paolis, F Blando, G Mita
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27975546/quantitative-and-qualitative-variation-of-volatile-oil-in-artemisia-annua-and-a-absinthium-species-from-wild-populations-in-republic-of-moldova
#14
C P Stefanache, A Spac, O C Bujor, D Danila, N Ciocarlan, C Carlen, X Simonnet
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27975545/comparative-phytochemical-study-on-the-phenolic-compounds-content-of-artemisia-annua-l-from-wild-populations-in-republic-of-moldova
#15
C P Stefanache, O C Bujor, R Necula, V Ghendov, A Trifan, C Carlen, X Simonnet
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27957318/a-systematic-review-of-anti-malarial-properties-immunosuppressive-properties-anti-inflammatory-properties-and-anti-cancer-properties-of-artemisia-annua
#16
REVIEW
Samira Alesaeidi, Sepide Miraj
Artemisia annua belongs to the asteraceae family, indigenous to the mild climate of Asia. The aim of this study was to overview its anti-malarial properties, immunosuppressive properties, anti-inflammatory properties and anti-cancer properties. This systematic review was carried out by searching studies in PubMed, Medline, Web of Science, and IranMedex databases. The initial search strategy identified approximately ninety eight references. In this study, forty six studies were accepted for further screening and met all of our inclusion...
October 2016: Electronic Physician
https://www.readbyqxmd.com/read/27930305/artemisia-annua-mutant-impaired-in-artemisinin-synthesis-demonstrates-importance-of-nonenzymatic-conversion-in-terpenoid-metabolism
#17
Tomasz Czechowski, Tony R Larson, Theresa M Catania, David Harvey, Geoffrey D Brown, Ian A Graham
Artemisinin, a sesquiterpene lactone produced by Artemisia annua glandular secretory trichomes, is the active ingredient in the most effective treatment for malaria currently available. We identified a mutation that disrupts the amorpha-4,11-diene C-12 oxidase (CYP71AV1) enzyme, responsible for a series of oxidation reactions in the artemisinin biosynthetic pathway. Detailed metabolic studies of cyp71av1-1 revealed that the consequence of blocking the artemisinin biosynthetic pathway is the redirection of sesquiterpene metabolism to a sesquiterpene epoxide, which we designate arteannuin X...
December 27, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27928651/effects-of-different-doses-of-cadmium-on-secondary-metabolites-and-gene-expression-in-artemisia-annua-l
#18
Liangyun Zhou, Guang Yang, Haifeng Sun, Jinfu Tang, Jian Yang, Yizhan Wang, Thomas Avery Garran, Lanping Guo
This study aims to elucidate the underlying molecular mechanisms of artemisinin accumulation induced by Cd. The effects of different Cd concentrations (0, 20, 60, and 120 μmol/L) on the biosynthesis of Artemisia annua L. were examined. Intermediate and end products were quantified by HPLC-ESI-MS/MS analysis. The expression of key biosynthesis enzymes was also determined by qRT-PCR. The results showed that the application of treatment with 60 and 120 μmol/L Cd for 3 days significantly improved the biosynthesis of artemisinic acid, arteannuin B, and artemisinin...
December 8, 2016: Frontiers of Medicine
https://www.readbyqxmd.com/read/27884407/-activity-of-artemisia-annua-infusions-on-epimastigotes-of-trypanosoma-cruzi
#19
Mariolga Berrizbeitia de Morgado, Yusmaris Cariaco Sifontes, José Imery Buiza, Pierre Lutgen
No abstract text is available yet for this article.
November 21, 2016: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/27867026/artemisinin-and-its-derivatives-in-treating-protozoan-infections-beyond-malaria
#20
REVIEW
Cecilia Shi Ni Loo, Nelson Siu Kei Lam, Deying Yu, Xin-Zhuan Su, Fangli Lu
Parasitic protozoan diseases continue to rank among the world's greatest global health problems, which are also common among poor populations. Currently available drugs for treatment present drawbacks, urging the need for more effective, safer, and cheaper drugs. Artemisinin (ART) and its derivatives are some of the most important classes of antimalarial agents originally derived from Artemisia annua L. However, besides the outstanding antimalarial and antischistosomal activities, ART and its derivatives also possess activities against other parasitic protozoa...
November 17, 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
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