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Artemisia annua

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https://www.readbyqxmd.com/read/28052518/effects-of-enzymatically-treated-artemisia-annua-l-on-growth-performance-and-some-blood-parameters-of-broilers-exposed-to-heat-stress
#1
Xiaoli Wan, Luyi Jiang, Haoran Zhong, Yufang Lu, Lili Zhang, Tian Wang
To evaluate the effects of enzymatically treated Artemisia annua L. (EA) on growth performance and some blood parameters of broilers exposed to heat stress (HS), 320 22-day-old Arbor Acres male broilers were randomly allotted into five groups with eight replicates of eight birds each. Broilers in the control group were housed at 22 ± 1°C and fed the basal diet. Broilers in the HS, HS-EA0.75 , HS-EA1.00 and HS-EA1.25 groups were reared under HS (34 ± 1°C for 8 h/day and 22 ± 1°C for 16 h/day), and fed basal diet with 0, 0...
January 4, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28049347/strategies-to-enhance-biologically-active-secondary-metabolites-in-cell-cultures-of-artemisia-current-trends
#2
Mohammad Ali, Bilal Haider Abbasi, Nisar Ahmad, Haji Khan, Gul Shad Ali
The genus Artemisia has been utilized worldwide due to its immense potential for protection against various diseases, especially malaria. Artemisia absinthium, previously renowned for its utilization in the popular beverage absinthe, is gaining resurgence due to its extensive pharmacological activities. Like A. annua, this species exhibits strong biological activities like antimalarial, anticancer and antioxidant. Although artemisinin was found to be the major metabolite for its antimalarial effects, several flavonoids and terpenoids are considered to possess biological activities when used alone and also to synergistically boost the bioavailability of artemisinin...
January 3, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/28035541/effect-of-artemisia-annua-extract-on-treating-active-rheumatoid-arthritis-a-randomized-controlled-trial
#3
Min Yang, Ming-Yang Guo, Yong Luo, Ming-Dong Yun, Jiao Yan, Tao Liu, Chang-Hong Xiao
OBJECTIVE: To investigate the effect and safety of the complementary use of the extract of Artemisia annua L. (EAA) on treating active rheumatoid arthritis (RA). METHODS: A randomized controlled clinical trial was performed. All the 159 participates with active RA were randomly assigned to the control group (80 cases) and EAA group (79 cases). In the control group, patients were medicated with leflflunomide and methotrexate for 48 weeks; and patients in the EAA group were administrated with leflflunomide, methotrexate plus EAA (30 g/d)...
December 29, 2016: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28001315/glandular-trichome-specific-wrky-1-promotes-artemisinin-biosynthesis-in-artemisia-annua
#4
Minghui Chen, Tingxiang Yan, Qian Shen, Xu Lu, Qifang Pan, Youran Huang, Yueli Tang, Xueqing Fu, Meng Liu, Weimin Jiang, Zongyou Lv, Pu Shi, Ya-Nan Ma, Xiaolong Hao, Lida Zhang, Ling Li, Kexuan Tang
Artemisinin is a type of sesquiterpene lactone well known as an antimalarial drug, and is specifically produced in glandular trichomes of Artemisia annua. However, the regulatory network for the artemisinin biosynthetic pathway remains poorly understood. Exploration of trichome-specific transcription factors would facilitate the elucidation of regulatory mechanism of artemisinin biosynthesis. The WRKY transcription factor GLANDULAR TRICHOME-SPECIFIC WRKY 1 (AaGSW1) was cloned and analysed in A. annua. AaGSW1 exhibited similar expression patterns to the trichome-specific genes of the artemisinin biosynthetic pathway and AP2/ERF transcription factor AaORA...
December 21, 2016: New Phytologist
https://www.readbyqxmd.com/read/28000518/artemisinin-inhibits-inflammatory-response-via-regulating-nf-%C3%AE%C2%BAb-and-mapk-signaling-pathways
#5
Ke Si Wang, Junbo Li, Zhe Wang, Chunliu Mi, Juan Ma, Lian Xun Piao, Guang Hua Xu, Xuezheng Li, Xuejun Jin
Artemisinin, isolated from the Chinese plant Artemisia annua, has been used for many years to treat different forms of malarial parasites. In this study, we explored the anti-inflammatory activity of artemisinin and the underlying mechanism of this action. We demonstrated that the anti-inflammatory effects of artemisinin in TPA-induced skin inflammation in mice. Then the artemisinin significantly inhibited the expression of NF-κB reporter gene induced by TNF-α in a dose-dependent manner. Artemisinin also inhibited TNF-α induced phosphorylation and degradation of IκBα, p65 nuclear translocation...
December 21, 2016: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/27976219/development-of-membrane-by-electrospinning-containing-semi-synthetic-derivatives-of-artemisia-annua-linnaeus
#6
F V Zanutto, Jdpm Segundo, Thc Salles, L Servat-Medina, I M Oliveira Sousa, M Chorilli, M A d'Ávila, M A Foglio
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27976017/role-of-impurities-in-purification-of-artemisinin-from-artemisia-annua-extracts
#7
C Malwade, H Qu, B G Rong, L P Christensen
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27975985/artemisia-annua-cell-cultures-as-tools-for-investigating-the-production-of-bioactive-compounds
#8
S Caretto, F Rizzello, M Durante, M S Lenucci, A De Paolis, F Blando, G Mita
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27975546/quantitative-and-qualitative-variation-of-volatile-oil-in-artemisia-annua-and-a-absinthium-species-from-wild-populations-in-republic-of-moldova
#9
C P Stefanache, A Spac, O C Bujor, D Danila, N Ciocarlan, C Carlen, X Simonnet
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27975545/comparative-phytochemical-study-on-the-phenolic-compounds-content-of-artemisia-annua-l-from-wild-populations-in-republic-of-moldova
#10
C P Stefanache, O C Bujor, R Necula, V Ghendov, A Trifan, C Carlen, X Simonnet
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27957318/a-systematic-review-of-anti-malarial-properties-immunosuppressive-properties-anti-inflammatory-properties-and-anti-cancer-properties-of-artemisia-annua
#11
REVIEW
Samira Alesaeidi, Sepide Miraj
Artemisia annua belongs to the asteraceae family, indigenous to the mild climate of Asia. The aim of this study was to overview its anti-malarial properties, immunosuppressive properties, anti-inflammatory properties and anti-cancer properties. This systematic review was carried out by searching studies in PubMed, Medline, Web of Science, and IranMedex databases. The initial search strategy identified approximately ninety eight references. In this study, forty six studies were accepted for further screening and met all of our inclusion...
October 2016: Electronic Physician
https://www.readbyqxmd.com/read/27930305/artemisia-annua-mutant-impaired-in-artemisinin-synthesis-demonstrates-importance-of-nonenzymatic-conversion-in-terpenoid-metabolism
#12
Tomasz Czechowski, Tony R Larson, Theresa M Catania, David Harvey, Geoffrey D Brown, Ian A Graham
Artemisinin, a sesquiterpene lactone produced by Artemisia annua glandular secretory trichomes, is the active ingredient in the most effective treatment for malaria currently available. We identified a mutation that disrupts the amorpha-4,11-diene C-12 oxidase (CYP71AV1) enzyme, responsible for a series of oxidation reactions in the artemisinin biosynthetic pathway. Detailed metabolic studies of cyp71av1-1 revealed that the consequence of blocking the artemisinin biosynthetic pathway is the redirection of sesquiterpene metabolism to a sesquiterpene epoxide, which we designate arteannuin X...
December 27, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27928651/effects-of-different-doses-of-cadmium-on-secondary-metabolites-and-gene-expression-in-artemisia-annua-l
#13
Liangyun Zhou, Guang Yang, Haifeng Sun, Jinfu Tang, Jian Yang, Yizhan Wang, Thomas Avery Garran, Lanping Guo
This study aims to elucidate the underlying molecular mechanisms of artemisinin accumulation induced by Cd. The effects of different Cd concentrations (0, 20, 60, and 120 μmol/L) on the biosynthesis of Artemisia annua L. were examined. Intermediate and end products were quantified by HPLC-ESI-MS/MS analysis. The expression of key biosynthesis enzymes was also determined by qRT-PCR. The results showed that the application of treatment with 60 and 120 μmol/L Cd for 3 days significantly improved the biosynthesis of artemisinic acid, arteannuin B, and artemisinin...
December 8, 2016: Frontiers of Medicine
https://www.readbyqxmd.com/read/27884407/-activity-of-artemisia-annua-infusions-on-epimastigotes-of-trypanosoma-cruzi
#14
Mariolga Berrizbeitia de Morgado, Yusmaris Cariaco Sifontes, José Imery Buiza, Pierre Lutgen
No abstract text is available yet for this article.
November 21, 2016: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/27867026/artemisinin-and-its-derivatives-in-treating-protozoan-infections-beyond-malaria
#15
REVIEW
Cecilia Shi Ni Loo, Nelson Siu Kei Lam, Deying Yu, Xin-Zhuan Su, Fangli Lu
Parasitic protozoan diseases continue to rank among the world's greatest global health problems, which are also common among poor populations. Currently available drugs for treatment present drawbacks, urging the need for more effective, safer, and cheaper drugs. Artemisinin (ART) and its derivatives are some of the most important classes of antimalarial agents originally derived from Artemisia annua L. However, besides the outstanding antimalarial and antischistosomal activities, ART and its derivatives also possess activities against other parasitic protozoa...
November 17, 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27857535/effect-of-gaeddongssuk-artemisia-annua-l-powder-on-quality-and-shelf-stability-of-emulsion-sausages-during-refrigerated-storage
#16
Hyoung-Joo Ham, Geun-Ho Kang, Yun-Sang Choi, Tae-Jun Jeong, Ko-Eun Hwang, Cheon-Jei Kim
The objective of this study was to evaluate effects of Gaeddongssuk powder (GP) on quality characteristics and shelf stability of emulsion sausages during storage. Proximate composition properties showed no significant differences in all treatment (p>0.05). Control showed the highest cooking loss while the treatment with GP showed decreased cooking loss depending on increasing GP content (p<0.05). Apparent viscosity of batter was increased as the amount of GP increased, whereas hardness of emulsion sausages was decreased with increasing GP level...
October 31, 2016: Korean Journal for Food Science of Animal Resources
https://www.readbyqxmd.com/read/27813878/antimalarial-drugs-as-immune-modulators-new-mechanisms-for-old-drugs
#17
Jie An, Mark Minie, Tomikazu Sasaki, Joshua J Woodward, Keith B Elkon
The best known of the naturally occurring antimalarial compounds are quinine, extracted from cinchona bark, and artemisinin (qinghao), extracted from Artemisia annua in China. These and other derivatives are now chemically synthesized and remain the mainstay of therapy to treat malaria. The beneficial effects of several of the antimalarial drugs (AMDs) on clinical features of autoimmune disorders were discovered by chance during World War II. In this review, we discuss the chemistry of AMDs and their mechanisms of action, emphasizing how they may impact multiple pathways of innate immunity...
January 14, 2017: Annual Review of Medicine
https://www.readbyqxmd.com/read/27806033/an-open-label-six-month-extension-study-to-investigate-the-safety-and-efficacy-of-an-extract-of-artemisia-annua-for-managing-pain-stiffness-and-functional-limitation-associated-with-osteoarthritis-of-the-hip-and-knee
#18
Sheena Hunt, Simon Stebbings, Debra McNamara
AIMS: This six-month single-centre open-label extension study, conducted at the University of Otago, Dunedin, follows from a previously published 12-week pilot double-blind randomised placebo-controlled study of dietary supplement, Arthrem® (ART) in patients with osteoarthritis (OA) of the hip or knee. The pilot double-blind study showed that treatment with ART 150 mg twice-daily was associated with clinically relevant pain reduction. The extension study aims were to assess longer-term safety and efficacy during six months' treatment following the pilot trial...
October 28, 2016: New Zealand Medical Journal
https://www.readbyqxmd.com/read/27781497/solvents-effects-on-crystallinity-and-dissolution-of-%C3%AE-artemether
#19
Jianghui Xu, Vikramjeet Singh, Xianzhen Yin, Parbeen Singh, Li Wu, Xiaonan Xu, Tao Guo, Lixin Sun, Shuangying Gui, Jiwen Zhang
β-artemether (ARM) is a widely used anti-malarial drug isolated from the Chinese antimalarial plant, Artemisia annua. The solvent effects on crystal habits and dissolution of ARM were thoroughly investigated and discussed herein. The ARM was recrystallized in nine different solvents of varied polarity, namely, methanol, ethanol, isopropanol, tetrahydrofuran, dichloromethane, trichloromethane, ethyl acetate, acetone and hexane by solvent evaporation method. The obtained crystals were morphologically characterized using scanning electron microscope (SEM)...
November 14, 2016: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/27773616/compartmentalized-metabolic-engineering-for-artemisinin-biosynthesis-and-effective-malaria-treatment-by-oral-delivery-of-plant-cells
#20
Karan Malhotra, Mayavan Subramaniyan, Khushboo Rawat, Md Kalamuddin, M Irfan Qureshi, Pawan Malhotra, Asif Mohmmed, Katrina Cornish, Henry Daniell, Shashi Kumar
Artemisinin is highly effective against drug-resistant malarial parasites, which affects nearly half of the global population and kills >500 000 people each year. The primary cost of artemisinin is the very expensive process used to extract and purify the drug from Artemisia annua. Elimination of this apparently unnecessary step will make this potent antimalarial drug affordable to the global population living in endemic regions. Here we reported the oral delivery of a non-protein drug artemisinin biosynthesized (∼0...
November 7, 2016: Molecular Plant
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