Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#21
JOURNAL ARTICLE
Marios Theologou, Panagiotis Varoutis
Objective Anterior cervical discectomy with fusion (ACDF) is the treatment of choice for cervical radiculopathy/myelopathy; however, it presents various complications. Endoscopic procedures may provide similar results and minimize adverse events. This review aimed to assess and compare the efficacy of anterior endoscopic cervical discectomy (AECD) and ACDF. Methods Major databases, registries, and other relevant material were screened for prospective trials directly comparing AECD and ACDF. No restrictions were imposed...
August 1, 2023: Turkish Neurosurgery
#22
JOURNAL ARTICLE
Elizaveta Ermakova, Kseniia Shaidullova, Oleg Gafurov, Alsu Kabirova, Dinara Nurmieva, Guzel Sitdikova
OBJECTIVES: Investigation of chronic homocysteine action on the excitability and N-methyl-D-aspartate (NMDA) sensitivity of the peripheral trigeminovascular system of rats. BACKGROUND: Migraine is a neurological disease that affects 15%-20% of the general population. Epidemiological observations show that an increase of the sulfur-containing amino acid homocysteine in plasma-called hyperhomocysteinemia-is associated with a high risk of migraine, especially migraine with aura...
April 22, 2024: Headache
#23
JOURNAL ARTICLE
Majid Rezvani, Ali Ahmadvand, Taravat Yazdanian, Parisa Azimi, Navid Askariardehjani
STUDY DESIGN: This was a retrospective study. PURPOSE: This study aimed to assess the value of the Spinal Infection Treatment Evaluation (SITE) score, Brighton Spondylodiscitis Score (BSDS), and Pola classification to predict the need for surgical intervention in patients with spondylodiscitis. OVERVIEW OF LITERATURE: Spondylodiscitis is a rare disease, and the prediction of its outcome is crucial in the decision-making process. METHODS: All case records were assessed to extract information on the American Spinal Injury Association (ASIA), Visual Analog Scale (VAS), and Japanese Orthopedic Association Back Pain Evaluation Questionnaire (JOABPEQ) scores before and after surgery...
April 23, 2024: Asian Spine Journal
#24
JOURNAL ARTICLE
Myungjin Kim, Jun Yong Kim, Won-Kyu Rhim, Gloria Cimaglia, Andrew Want, James E Morgan, Pete A Williams, Chun Gwon Park, Dong Keun Han, Seungsoo Rho
The progressive and irreversible degeneration of retinal ganglion cells (RGCs) and their axons is the major characteristic of glaucoma, a leading cause of irreversible blindness worldwide. Nicotinamide adenine dinucleotide (NAD) is a cofactor and metabolite of redox reaction critical for neuronal survival. Supplementation with nicotinamide (NAM), a precursor of NAD, can confer neuroprotective effects against glaucomatous damage caused by an age-related decline of NAD or mitochondrial dysfunction, reflecting the high metabolic activity of RGCs...
April 22, 2024: Acta Neuropathologica Communications
#25
JOURNAL ARTICLE
Carl A Gold, Rachel Jensen, Marzena Sasnal, Heather S Day, Rebecca K Miller-Kuhlmann, Rebecca L Blankenburg, Caroline E Rassbach, Arden M Morris, James R Korndorffer, Aussama K Nassar
BACKGROUND: While communication is an essential skill for providing effective medical care, it is infrequently taught or directly assessed, limiting targeted feedback and behavior change. We sought to evaluate the impact of a multi-departmental longitudinal residency communication coaching program. We hypothesized that program implementation would result in improved confidence in residents' communication skills and higher-quality faculty feedback. METHODS: The program was implemented over a 3-year period (2019-2022) for surgery and neurology residents at a single institution...
April 22, 2024: BMC Medical Education
#26
JOURNAL ARTICLE
Zhao Li, Shenghui Yu, Lin Li, Chao Zhou, Lin Wang, Shuang Tang, Nina Gu, Zhaosi Zhang, Zhijian Huang, Hong Chen, Wei Tang, Yingwen Wang, Xiaomin Yang, Xiaochuan Sun, Jin Yan
BACKGROUND: White matter injury (WMI) is an important pathological process after traumatic brain injury (TBI). The correlation between white matter functions and the myeloid cells expressing triggering receptor-2 (TREM2) has been convincingly demonstrated. Moreover, a recent study revealed that microglial sterol metabolism is crucial for early remyelination after demyelinating diseases. However, the potential roles of TREM2 expression and microglial sterol metabolism in WMI after TBI have not yet been explored...
April 2024: Clinical and Translational Medicine
#27
JOURNAL ARTICLE
Jonathan Z Pan, Zhanqiang Wang, Wei Sun, Peipei Pan, Wei Li, Yongtao Sun, Shoulin Chen, Amity Lin, Wulin Tan, Liangliang He, Jacob Greene, Virginia Yao, Lijun An, Rich Liang, Qifeng Li, Jessica Yu, Lingyi Zhang, Nikolaos Kyritsis, Xuan Duong Fernandez, Sara Moncivais, Esmeralda Mendoza, Pamela Fung, Gongming Wang, Xinhuan Niu, Qihang Du, Zhaoyang Xiao, Yuwen Chang, Peiyuan Lv, J Russell Huie, Abel Torres-Espin, Adam R Ferguson, Debra D Hemmerle, Jason F Talbott, Philip R Weinstein, Lisa U Pascual, Vineeta Singh, Anthony M DiGiorgio, Rajiv Saigal, William D Whetstone, Geoffrey T Manley, Sanjay S Dhall, Jacqueline C Bresnahan, Mervyn Maze, Xiangning Jiang, Neel S Singhal, Michael S Beattie, Hua Su, Zhonghui Guan
BACKGROUND: Although many molecules have been investigated as biomarkers for spinal cord injury (SCI) or ischemic stroke, none of them are specifically induced in central nervous system (CNS) neurons following injuries with low baseline expression. However, neuronal injury constitutes a major pathology associated with SCI or stroke and strongly correlates with neurological outcomes. Biomarkers characterized by low baseline expression and specific induction in neurons post-injury are likely to better correlate with injury severity and recovery, demonstrating higher sensitivity and specificity for CNS injuries compared to non-neuronal markers or pan-neuronal markers with constitutive expressions...
April 2024: Clinical and Translational Medicine
#28
REVIEW
Jacopo Proietti, Geraldine B Boylan, Brian H Walsh
Early induced therapeutic hypothermia represents the cornerstone treatment in neonates with probable hypoxic-ischemic encephalopathy. The selection of patients for treatment usually involves meeting criteria indicating evidence of perinatal hypoxia-ischemia and the presence of moderate or severe encephalopathy. In this review, we highlight the variability that exists between some of the different regional and national eligibility guidelines. Determining the potential presence of perinatal hypoxia-ischemia may require either one, two or three signs amongst history of acute perinatal event, prolonged resuscitation at delivery, abnormal blood gases and low Apgar score, with a range of cutoff values...
April 22, 2024: Pediatric Research
#29
JOURNAL ARTICLE
S Chakithandy, H Nazzal, M Matoug-Elwerfelli, S Narasimhan, S Uddin, K S Prabhu, L Zarif, N Mumtaz, A Sharma, M Al-Khelaifi
PURPOSE: Neurotoxicity concerns have been raised over general anesthesia and sedation medication use in children. Such concerns are largely based on animal studies, historical anesthetic agents, and assessment tools, thus warranting further investigations. Blood biomarkers in detecting neuronal inflammation and apoptosis are novel methods for detecting neuronal damage. Therefore, the aim of this feasibility study was to assess the usefulness of the levels of four plasma biomarkers in dental general anesthesia (DGA) as surrogate markers of neurotoxicity in children...
April 22, 2024: European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry
#30
REVIEW
Gabriel Verly, Thiffany Delfino, Leonardo de Barros Oliveira, Sávio Batista, Marcelo Porto Sousa, Rodrigo Schevz, Marcio Yuri Ferreira, Raphael Bertani
The treatment for peripheral nerve sheath tumors (PNSTs) is based on surgical excision and the primary goal is to improve symptoms whilst preserving neurological function. In order to improve this technique, surgeons may use sodium fluorescein (SF) to help visualize the neoplasm and, consequently, facilitate its removal. Aiming to assess the efficacy of this emerging surgical strategy, we conducted a systematic review and single-arm meta-analysis. We conducted a systematic search on the PubMed, Embase, and Web of Science databases, following the PRISMA guidelines...
April 23, 2024: Neurosurgical Review
#31
JOURNAL ARTICLE
Guedi Ali Barreh, Ikram Sghaier, Youssef Abida, Alya Gharbi, Amina Nasri, Saloua Mrabet, Amira Souissi, Mouna Ben Djebara, Sameh Trabelsi, Imen Kacem, Amina Gargouri-Berrachi, Riadh Gouider
BACKGROUND: LRRK2-G2019S is the most frequent mutation in North African Parkinson's disease (PD) patients.Data on its impact on disease progression and treatment response remains elusive.Therefore, we aimed to explore the clinical features,treatments,and complications through the disease course of PD Tunisian patients according to their LRRK2-G2019S profile. METHODS: Longitudinal retrospective study conducted in the department of Neurology,Razi University Hospital...
April 23, 2024: Journal of Movement Disorders
#32
JOURNAL ARTICLE
Rei Murakami, Hirotaka Watanabe, Hideko Hashimoto, Mayu Kashiwagi-Hakozaki, Tadafumi Hashimoto, Celeste M Karch, Takeshi Iwatsubo, Hideyuki Okano
Genetic variants in the apolipoprotein E ( APOE ) gene affect the onset and progression of Alzheimer's disease (AD). The APOE Christchurch ( APOE Ch) variant has been identified as the most prominent candidate for preventing the onset and progression of AD. In this study, we generated isogenic APOE3 Ch/ 3 Ch human induced pluripotent stem cells (iPSCs) from APOE3 / 3 healthy control female iPSCs and induced them into astrocytes. RNA expression analysis revealed the inherent resilience of APOE3 Ch/ 3 Ch astrocytes to induce a reactive state in response to inflammatory cytokines...
April 22, 2024: Journal of Neuroscience
#33
JOURNAL ARTICLE
Nicole Yun Ching Chen, Melissa Yi Ling Tan, Jing Xu, Lijun Zuo, Yanhong Dong
INTRODUCTION: Vascular diseases, such as stroke and heart failure (HF), are associated with cognitive decline. Vascular cognitive impairment (CI) is commonly found in patients who had a stroke and with HF, ranging from mild CI to dementia. Early detection of CI is crucial for effective management and rehabilitation. This study aimed to develop the VasCog Screen test, a screening tool to detect CI in patients who had a stroke and with HF. METHOD: 427 patients who had a stroke and with HF were assessed using cognitive measures including Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA) and a formal neuropsychological battery...
April 22, 2024: Stroke and Vascular Neurology
#34
JOURNAL ARTICLE
The effectiveness of hesperidin on bisphenol A-induced spinal cord toxicity in a diabetic rat model.
Ahmad Yahyazadeh
The potential health risks of bisphenol A (BS) and diabetes (DI) has sparked public concern due to be ubiquitous worldwide. The purpose of this study was to investigate the detrimental impact of BS (200 mg/kg) on the spinal cord tissue in a rat diabetic model. We also evaluated the antioxidant capacity of hesperidin (HS) (100 mg/kg) on spinal cord in BS-treated diabetic rat. Seventy male Wistar albino rats, weighing 180-230 g and 8 weeks old, were randomly chosen, and assigned into seven groups of 10 rats: Control (KON), BS, DI, BS+DI, HS+BS, HS+DI, HS+BS+DI...
April 20, 2024: Toxicon: Official Journal of the International Society on Toxinology
#35
JOURNAL ARTICLE
Ana Flavia F Ferreira, Henning Ulrich, Zhong-Ping Feng, Hong-Shuo Sun, Luiz Roberto Britto
Parkinson's disease (PD) is a neurodegenerative disease characterized by dopaminergic neuron death and neuroinflammation. Emerging evidence points to the involvement of the transient receptor potential melastatin 2 (TRPM2) channel in neuron death and glial activation in several neurodegenerative diseases. However, the involvement of TRPM2 in PD and specifically its relation to the neuroinflammation aspect of the disease remains poorly understood. Here, we hypothesized that AG490, a TRPM2 inhibitor, can be used as a treatment in a mouse model of PD...
April 20, 2024: Experimental Neurology
#36
JOURNAL ARTICLE
Nawaf Yassi, Henry Zhao, Leonid Churilov, Teddy Y Wu, Henry Ma, Huy-Thang Nguyen, Andrew Cheung, Atte Meretoja, Duy Ton Mai, Timothy Kleinig, Jiann-Shing Jeng, Philip M C Choi, Phuc Dang Duc, Helen Brown, Annemarei Ranta, Neil Spratt, Geoffrey C Cloud, Hao-Kuang Wang, Rohan Grimley, Karim Mahawish, Der-Yang Cho, Darshan Shah, Thai My Phuong Nguyen, Gagan Sharma, Vignan Yogendrakumar, Bernard Yan, Emma L Harrison, Michael Devlin, Dennis Cordato, Nicolas Martinez-Majander, Daniel Strbian, Vincent Thijs, Lauren M Sanders, David Anderson, Mark W Parsons, Bruce C V Campbell, Geoffrey A Donnan, Stephen M Davis
BACKGROUND: Tranexamic acid, an antifibrinolytic agent, might attenuate haematoma growth after an intracerebral haemorrhage. We aimed to determine whether treatment with intravenous tranexamic acid within 2 h of an intracerebral haemorrhage would reduce haematoma growth compared with placebo. METHODS: STOP-MSU was an investigator-led, double-blind, randomised, phase 2 trial conducted at 24 hospitals and one mobile stroke unit in Australia, Finland, New Zealand, Taiwan, and Viet Nam...
April 19, 2024: Lancet Neurology
#37
JOURNAL ARTICLE
Jingyi Tong, Tingting Ji, Nan Liu, Yibin Chen, Zongjun Li, Xuejuan Lin, Yi Xing, Qifu Li
OBJECTIVE: Acute ischemic stroke (AIS) stands as a leading cause of death and disability globally. This study aimed to investigate the risk factors linked with AIS in patients undergoing maintenance hemodialysis (MHD) and to create and validate nomogram models. METHODS: We examined the medical records of 314 patients with stage 5 chronic kidney disease (CKD5) undergoing MHD, who sought neurology outpatient department consultation for suspected AIS symptoms between January 2018 and December 2023...
April 22, 2024: Cerebrovascular Diseases Extra
#38
JOURNAL ARTICLE
Robert J Fox, Bruce A C Cree, Jérôme de Sèze, Ralf Gold, Hans-Peter Hartung, Douglas Jeffery, Ludwig Kappos, Xavier Montalban, Bianca Weinstock-Guttman, Carol M Singh, Arman Altincatal, Nicholas Belviso, Robin L Avila, Pei-Ran Ho, Ray Su, Robert Engle, Dipen Sangurdekar, Carl de Moor, Elizabeth Fisher, Bernd C Kieseier, Richard A Rudick
BACKGROUND AND OBJECTIVES: Serum neurofilament light chain (sNfL) levels correlate with multiple sclerosis (MS) disease activity, but the dynamics of this correlation are unknown. We evaluated the relationship between sNfL levels and radiologic MS disease activity through monthly assessments during the 24-week natalizumab treatment interruption period in RESTORE (NCT01071083). METHODS: In the RESTORE trial, participants with relapsing forms of MS who had received natalizumab for ≥12 months were randomized to either continue or stop natalizumab and followed with MRI and blood draws every 4 weeks to week 28 and again at week 52 The sNfL was measured, and its dynamics were correlated with the development of gadolinium-enhancing (Gd+) lesions...
May 14, 2024: Neurology
#39
JOURNAL ARTICLE
Nils Skajaa, Kristina Laugesen, Julie C Lauffenburger, Lee H Schwamm, Henrik T Sørensen, Elisabetta Patorno
BACKGROUND AND OBJECTIVES: Understanding trends in the use of medications for secondary stroke prevention is crucial for identifying areas for improvement in stroke care. We examined the use of lipid-lowering, antihypertensive, glucose-lowering, oral anticoagulant, and antiplatelet medications after ischemic stroke hospitalization, from 2005 to 2021. METHODS: Using nationwide registries in Denmark, we identified a cohort of patients discharged from hospital with a first-time or recurrent ischemic stroke (N = 150,744)...
May 14, 2024: Neurology
#40
JOURNAL ARTICLE
Abdul Aziz Hulleck, Aamna Alshehhi, Marwan El Rich, Raviha Khan, Rateb Katmah, Mahdi Mohseni, Navid Arjmand, Kinda Khalaf
Evaluation of human gait through smartphone-based pose estimation algorithms provides an attractive alternative to costly lab-bound instrumented assessment and offers a paradigm shift with real time gait capture for clinical assessment. Systems based on smart phones, such as OpenPose and BlazePose have demonstrated potential for virtual motion assessment but still lack the accuracy and repeatability standards required for clinical viability. Seq2seq architecture offers an alternative solution to conventional deep learning techniques for predicting joint kinematics during gait...
April 22, 2024: IEEE Transactions on Neural Systems and Rehabilitation Engineering
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
