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https://www.readbyqxmd.com/read/28734188/the-effects-of-neurologic-assessment-e-learning-in-nurses
#1
Ji Yeon Shin, S Barry Issenberg, Young Sook Roh
BACKGROUND: A firm understanding of the preliminary assessment of a patient with neurological disorders is needed for ensuring optimal patient outcomes. OBJECTIVES: The purpose of this study is to evaluate the effects of using e-learning on neurologic assessment knowledge, ability, and self-confidence among nurses. DESIGN: This study used a non-equivalent control group pretest-posttest design. SETTINGS: Nurses working in the neurology and neurosurgery wards, Republic of Korea PARTICIPANTS: A convenience sample of 50 nurses was assigned to either the experimental group (n=24) or the control group (n=26)...
July 15, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/28732280/evaluation-of-a-novel-median-power-spectrogram-for-seizure-detection-by-non-neurophysiologists
#2
Peter Yan, Tamar Melman, Sherry Yan, Munkhzul Otgonsuren, Zachary Grinspan
PURPOSE: (1) To evaluate how well resident physicians use a novel EEG spectral analysis tool (the median power spectrogram; MPS) to detect seizures. (2) To assess the capability of the MPS to identify different seizure types. METHODS: 120 EEG records from children with intractable seizures were converted to MPS by taking the median power across leads and using multi-taper spectral estimation. Twelve blinded neurology residents were trained to interpret the spectrogram with a five-minute video tutorial and post-test...
June 15, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28731517/mental-steps-differential-activation-of-internal-pacemakers-in-motor-imagery-and-in-mental-imitation-of-gait
#3
Lucia Maria Sacheli, Laura Zapparoli, Carlo De Santis, Matteo Preti, Catia Pelosi, Nicola Ursino, Alberto Zerbi, Giuseppe Banfi, Eraldo Paulesu
Gait imagery and gait observation can boost the recovery of locomotion dysfunctions; yet, a neurologically justified rationale for their clinical application is lacking as much as a direct comparison of their neural correlates. Using functional magnetic resonance imaging, we measured the neural correlates of explicit motor imagery of gait during observation of in-motion videos shot in a park with a steady cam (Virtual Walking task). In a 2 × 2 factorial design, we assessed the modulatory effect of gait observation and of foot movement execution on the neural correlates of the Virtual Walking task: in half of the trials, the participants were asked to mentally imitate a human model shown while walking along the same route (mental imitation condition); moreover, for half of all the trials, the participants also performed rhythmic ankle dorsiflexion as a proxy for stepping movements...
July 21, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28731489/sexual-health-adherence-to-mediterranean-diet-body-weight-physical-activity-and-mental-state-factors-correlated-to-each-other
#4
Pier A Della Camera, Simone Morselli, Gianmartin Cito, Giovanni Tasso, Andrea Cocci, Nicola Laruccia, Fabrizio Travaglini, Dario Del Fabbro, Antonio R Mottola, Mauro Gacci, Sergio Serni, Marco Carini, Alessandro Natali
INTRODUCTION: Mediterranean diet has shown a protective role against cardiovascular disease, diabetes, cancer onset, microvascular damage and dementia in many trials. Our purpose is the assessment of a correlation between physical activity, Mediterranean diet, body mass index (BMI), depression and erection disorder (ED). METHODS: After having signed disclaimer to the study participation, we administered the IIEF 15 questionnaire (International Index of Erectil Function), the Hamilton questionnaire for major depression, the Med-Diet Questionnaire, the Ipaq Questionnaire (International Index of Physical Activity) to 245 patients and calculated the BMI...
July 14, 2017: Urologia
https://www.readbyqxmd.com/read/28731401/intraoperative-perception-and-estimates-on-extent-of-resection-during-awake-glioma-surgery-overcoming-the-learning-curve
#5
Darryl Lau, Shawn L Hervey-Jumper, Seunggu J Han, Mitchel S Berger
OBJECTIVE There is ample evidence that extent of resection (EOR) is associated with improved outcomes for glioma surgery. However, it is often difficult to accurately estimate EOR intraoperatively, and surgeon accuracy has yet to be reviewed. In this study, the authors quantitatively assessed the accuracy of intraoperative perception of EOR during awake craniotomy for tumor resection. METHODS A single-surgeon experience of performing awake craniotomies for tumor resection over a 17-year period was examined...
July 21, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28731207/polyclonal-and-monoclonal-antibodies-for-treating-acute-rejection-episodes-in-kidney-transplant-recipients
#6
REVIEW
Angela C Webster, Sunny Wu, Krishna Tallapragada, Min Young Park, Jeremy R Chapman, Sue J Carr
BACKGROUND: Registry data shows that the incidence of acute rejection has been steadily falling. Approximately 10% to 35% of kidney recipients will undergo treatment for at least one episode of acute rejection within the first post-transplant year. Treatment options include pulsed steroid therapy, the use of an antibody preparation, the alteration of background immunosuppression, or combinations of these options. Over recent years, new treatment strategies have evolved, and in many parts of the world there has been an increase in use of tacrolimus and mycophenolate and a reduction in the use of cyclosporin and azathioprine use as baseline immunosuppression to prevent acute rejection...
July 20, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28730861/comparative-outcomes-in-children-and-adults-with-anti-n-methyl-d-aspartate-anti-nmda-receptor-encephalitis
#7
Eliza Gordon-Lipkin, Anusha K Yeshokumar, Deanna Saylor, Ana Arenivas, John C Probasco
This study compared neurologic disability and adaptive function in children and adults >1 year following anti- N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis diagnosis. Retrospective record review identified 12 patients with anti-NMDAR encephalitis. At last follow-up, all surviving patients had "good" modified Rankin Score (0-2). Four children, 6 adults, and their families participated in a telephone interview. Median duration since diagnosis was similar for children (2.42 years, interquartile range 2...
January 1, 2017: Journal of Child Neurology
https://www.readbyqxmd.com/read/28730563/functional-connectivity-and-cognitive-impairment-in-migraine-with-and-without-aura
#8
Viviana Lo Buono, Lilla Bonanno, Francesco Corallo, Laura Rosa Pisani, Riccardo Lo Presti, Rosario Grugno, Giuseppe Di Lorenzo, Placido Bramanti, Silvia Marino
BACKGROUND: Several fMRI studies in migraine assessed resting state functional connectivity in different networks suggesting that this neurological condition was associated with brain functional alteration. The aim of present study was to explore the association between cognitive functions and cerebral functional connectivity, in default mode network, in migraine patients without and with aura, during interictal episodic attack. METHODS: Twenty-eight migraine patients (14 without and 14 with aura) and 14 matched normal controls, were consecutively recruited...
December 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28730313/derivatization-free-lc-ms-ms-method-for-estrogen-quantification-in-mouse-brain-highlights-a-local-metabolic-regulation-after-oral-versus-subcutaneous-administration
#9
Ecaterina Lozan, Svitlana Shinkaruk, Shaam Alice Al Abed, Valérie Lamothe, Mylène Potier, Aline Marighetto, Jean-Marie Schmitter, Catherine Bennetau-Pelissero, Corinne Buré
17β-Estradiol (17β-E2) is a steroid with pleiotropic actions. In addition to being a sexual hormone, it is also produced in the brain where it modulates the reproductive axis. It has been shown that 17β-E2 also acts on synaptic plasticity and plays a role in neurological pathways and in neurodegenerative diseases. Assaying this steroid in the brain is thus interesting to improve our knowledge of 17β-E2 effects in the brain. However, 17β-E2 concentration in the central nervous system has been reported to be of a few nanograms per gram wet weight (nanomolar range concentration); therefore, its quantification requires both an efficient extraction process and a sensitive detection method...
July 20, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28730152/zebrafish-get-connected-investigating-neurotransmission-targets-and-alterations-in-chemical-toxicity
#10
Katharine A Horzmann, Jennifer L Freeman
Neurotransmission is the basis of neuronal communication and is critical for normal brain development, behavior, learning, and memory. Exposure to drugs and chemicals can alter neurotransmission, often through unknown pathways and mechanisms. The zebrafish (Danio rerio) model system is increasingly being used to study the brain and chemical neurotoxicity. In this review, the major neurotransmitter systems, including glutamate, GABA, dopamine, norepinephrine, serotonin, acetylcholine, histamine, and glutamate are surveyed and pathways of synthesis, transport, metabolism, and action are examined...
September 2016: Toxics
https://www.readbyqxmd.com/read/28729927/fatigue-and-cognition-pupillary-responses-to-problem-solving-in-early-multiple-sclerosis-patients
#11
Sigrid A de Rodez Benavent, Gro O Nygaard, Hanne F Harbo, Siren Tønnesen, Piotr Sowa, Nils I Landrø, Marte Wendel-Haga, Lars Etholm, Kristian B Nilsen, Liv Drolsum, Emilia Kerty, Elisabeth G Celius, Bruno Laeng
INTRODUCTION: In early multiple sclerosis (MS) patients, cognitive changes and fatigue are frequent and troublesome symptoms, probably related to both structural and functional brain changes. Whether there is a common cause of these symptoms in MS is unknown. In theory, an altered regulation of central neuropeptides can lead to changes in regulation of autonomic function, cognitive difficulties, and fatigue. Direct measurements of central neuropeptides are difficult to perform, but measurements of the eye pupil can be used as a reliable proxy of function...
July 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28729849/nerve-decompression-and-restless-legs-syndrome-a-retrospective-analysis
#12
James C Anderson, Megan L Fritz, John-Michael Benson, Brian L Tracy
INTRODUCTION: Restless legs syndrome (RLS) is a prevalent sleep disorder affecting quality of life and is often comorbid with other neurological diseases, including peripheral neuropathy. The mechanisms related to RLS symptoms remain unclear, and treatment options are often aimed at symptom relief rather than etiology. RLS may present in distinct phenotypes often described as "primary" vs. "secondary" RLS. Secondary RLS is often associated with peripheral neuropathy. Nerve decompression surgery of the common and superficial fibular nerves is used to treat peripheral neuropathy...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28729823/administration-of-tauroursodeoxycholic-acid-attenuates-early-brain-injury-via-akt-pathway-activation
#13
Dongdong Sun, Gang Gu, Jianhao Wang, Yan Chai, Yueshan Fan, Mengchen Yang, Xin Xu, Weiwei Gao, Fei Li, Dongpei Yin, Shuai Zhou, Xin Chen, Jianning Zhang
Traumatic brain injury (TBI) is one of the leading causes of trauma-induced mortality and disability, and emerging studies have shown that endoplasmic reticulum (ER) stress plays an important role in the pathophysiology of TBI. Tauroursodeoxycholic acid (TUDCA), a hydrophilic bile acid, has been reported to act as an ER stress inhibitor and chemical chaperone and to have the potential to attenuate apoptosis and inflammation. To study the effects of TUDCA on brain injury, we subjected mice to TBI with a controlled cortical impact (CCI) device...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28729755/social-cognition-deficits-current-position-and-future-directions-for-neuropsychological-interventions-in-cerebrovascular-disease
#14
REVIEW
Progress Njomboro
Neuropsychological assessments of cognitive dysfunction in cerebrovascular illness commonly target basic cognitive functions involving aspects of memory, attention, language, praxis, and number processing. Here, I highlight the clinical importance of often-neglected social cognition functions. These functions recruit a widely distributed neural network, making them vulnerable in most cerebrovascular diseases. Sociocognitive deficits underlie most of the problematic social conduct observed in patients and are associated with more negative clinical outcomes (compared to nonsocial cognitive deficits)...
2017: Behavioural Neurology
https://www.readbyqxmd.com/read/28729143/the-prognostic-impact-of-ventricular-opening-in-glioblastoma-surgery-a-retrospective-single-center-analysis
#15
Felix Behling, Marlene Kaltenstadler, Susan Noell, Jens Schittenhelm, Benjamin Bender, Franziska Eckert, Ghazaleh Tabatabai, Marcos Tatagiba, Marco Skardelly
OBJECTIVE: Ventricular opening during glioblastoma (GBM) resection is controversial. Sufficient evidence regarding its prognostic role is missing. We investigated the impact of ventricular opening on overall survival (OS), hydrocephalus development and postoperative morbidity in GBM patients. METHODS: Patients who underwent primary GBM resection between 2006 and 2013 were assessed retrospectively. Established predictors for overall survival (age, Karnofsky performance status, extent of resection (EOR), O-6-methylguanine-DNA methyltransferase promoter methylation status, isocitrate dehydrogenase mutation status) and further clinical data (postoperative status, further treatment, preoperative tumor volume, proximity to the ventricle) were included in univariate and multivariate analyses...
July 17, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28728503/facilitators-and-barriers-to-international-collaboration-in-spinal-cord-injury-results-from-a-survey-of-clinicians-and-researchers
#16
Vanessa K Noonan, Elaine Chan, Kent Bassett-Spiers, David J Berlowitz, Fin Biering-Sørensen, Susan Charlifue, Marnie Graco, Keith C Hayes, Jane Horsewell, Phalgun Joshi, Debora Markelis, Verna Smith, Zeina Waheed, Doug J Brown
International collaboration in spinal cord injury (SCI) clinical research is necessary to overcome the challenges often encountered by clinicians and researchers including participant recruitment, high cost and the need for highly specialized expertise. However, international collaboration poses its own obstacles. The objective of this study was to conduct an international online survey to assess barriers and facilitators to international SCI clinical research, potential initiatives to facilitate future collaborations and the use of SCI-specific data sets and standards...
July 20, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28727883/corneal-confocal-microscopy-is-emerging-as-a-powerful-diagnostic-tool-for-assessing-systemic-neurologic-disease
#17
Nathan Efron
No abstract text is available yet for this article.
July 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28727882/corneal-confocal-microscopy-an-imaging-endpoint-for-axonal-degeneration-in-multiple-sclerosis
#18
Ioannis N Petropoulos, Saadat Kamran, Yi Li, Adnan Khan, Georgios Ponirakis, Naveed Akhtar, Dirk Deleu, Ashfaq Shuaib, Rayaz A Malik
Purpose: To evaluate whether corneal confocal microscopy (CCM) detects axonal degeneration and whether this is associated with retinal nerve fiber degeneration and clinical disability in patients with multiple sclerosis (MS). Methods: Twenty-five patients with MS and 25 healthy control subjects underwent CCM, optical coherence tomography (OCT), and assessment of neurological disability using the expanded disability status scale (EDSS) and MS severity score (MSSS)...
July 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28727834/systematic-review-outcome-reporting-bias-is-a-problem-in-high-impact-factor-neurology-journals
#19
Benjamin Howard, Jared T Scott, Mark Blubaugh, Brie Roepke, Caleb Scheckel, Matt Vassar
BACKGROUND: Selective outcome reporting is a significant methodological concern. Comparisons between the outcomes reported in clinical trial registrations and those later published allow investigators to understand the extent of selection bias among trialists. We examined the possibility of selective outcome reporting in randomized controlled trials (RCTs) published in neurology journals. METHODS: We searched PubMed for randomized controlled trials from Jan 1, 2010 -Dec 31, 2015 published in the top 3 impact factor neurology journals...
2017: PloS One
https://www.readbyqxmd.com/read/28727832/neurosurgeon-academic-impact-is-associated-with-clinical-outcomes-after-clipping-of-ruptured-intracranial-aneurysms
#20
Naif M Alotaibi, George M Ibrahim, Justin Wang, Daipayan Guha, Muhammad Mamdani, Tom A Schweizer, R Loch Macdonald
BACKGROUND: Surgeon-dependent factors such as experience and volume are associated with patient outcomes. However, it is unknown whether a surgeon's research productivity could be related to outcomes. The main aim of this study is to investigate the association between the surgeon's academic productivity and clinical outcomes following neurosurgical clipping of ruptured aneurysms. METHODS: We performed a post-hoc analysis of 3567 patients who underwent clipping of ruptured intracranial aneurysms in the randomized trials of tirilazad mesylate from 1990 to 1997...
2017: PloS One
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