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https://www.readbyqxmd.com/read/29783067/motor-retraining-more-for-functional-movement-disorders-outcomes-from-a-one-week-multidisciplinary-rehabilitation-program
#1
Alexandra Jacob, Darryl Kaelin, Abbey Roach, Craig Ziegler, Kathrin LaFaver
BACKGROUND: Functional Movement Disorders (FMD) are conditions of abnormal motor control thought to be caused by psychological factors. These disorders are commonly seen in neurological practice and prognosis is often poor. No consensus treatment guidelines have been established, however the role of physical therapy in addition to psychotherapy has increasingly been recognized. This study reports patient outcomes from a multidisciplinary FMD treatment program using motor retraining (MoRe) strategies...
May 18, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29782953/electrodermal-reactivity-to-emotional-stimuli-in-healthy-subjects-and-patients-with-disorders-of-consciousness
#2
Jacques Luauté, Anne Dubois, Lizette Heine, Chloé Guironnet, Ariane Juliat, Valérie Gaveau, Barbara Tillmann, Fabien Perrin
OBJECTIVES: After a coma, one major challenge is the detection of awareness in patients with disorders of consciousness. In some patients, the only manifestation indicative of awareness is an appropriate emotional response. Preferred music is a powerful medium to elicit emotions and auto-biographical memory. Furthermore, music has been shown to improve cognitive functions both in healthy subjects and patients with neurological impairment. We hypothesized that signs of awareness could be enhanced in some patients with disorders of consciousness under appropriate emotional stimulation such as preferred music and also probably preferred odors...
May 18, 2018: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29782356/acute-neurologic-complications-during-extracorporeal-membrane-oxygenation-a-systematic-review
#3
Raoul Sutter, Kai Tisljar, Stephan Marsch
OBJECTIVES: We determine the frequency, risk factors, and mortality of neurologic complications in adults on extracorporeal membrane oxygenation and propose an algorithm for preventive strategies. DATA SOURCES: PubMed, Embase, and Cochrane databases. STUDY SELECTION: Screening was performed using predefined search terms to identify cohort studies reporting neurologic complications in adults during extracorporeal membrane oxygenation from 1990 to 2017...
May 18, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29781732/role-of-positive-lifestyle-activities-on-mood-cognition-well-being-and-disease-characteristics-in-multiple-sclerosis
#4
Lauren B Strober, Alexandra Becker, John J Randolph
Multiple sclerosis (MS) is a neurological condition associated with a wide variety of physical, cognitive, and mood-related symptoms. While disease-modifying treatment has been shown to reduce the severity and frequency of MS symptom relapses, engagement in certain daily activities holds promise as an adjunctive treatment to better manage disease sequelae. The present study sought to determine whether healthy nutritional choices, exercise, and social/intellectual engagement impacts functioning in individuals with MS...
July 2018: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/29781583/altered-white-matter-connectivity-associated-with-visual-hallucinations-following-occipital-stroke
#5
Sara A Rafique, John R Richards, Jennifer K E Steeves
INTRODUCTION: Visual hallucinations that arise following vision loss stem from aberrant functional activity in visual cortices and an imbalance of activity across associated cortical and subcortical networks subsequent to visual pathway damage. We sought to determine if structural changes in white matter connectivity play a role in cases of chronic visual hallucinations associated with visual cortical damage. METHODS: We performed diffusion tensor imaging (DTI) and probabilistic fiber tractography to assess white matter connectivity in a patient suffering from continuous and disruptive phosphene (simple) visual hallucinations for more than 2 years following right occipital stroke...
May 21, 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29781569/pediatric-superior-vena-cava-syndrome-an-evidence-based-systematic-review-of-the-literature
#6
REVIEW
Fadi Nossair, Peter Schoettler, Joanne Starr, Anthony K C Chan, Ivan Kirov, Bosco Paes, Arash Mahajerin
Superior vena cava syndrome (SVCS) results in vascular, respiratory, and neurologic compromise. A systematic search was conducted to determine the prevalence of pediatric SVCS subtypes and identify clinical characteristics/treatment strategies that may influence overall outcomes. Data from 101 case reports/case series (142 patients) were analyzed. Morbidity (30%), mortality (18%), and acute complications (55%) were assessed as outcomes. Thrombosis was present in 36%, with multi-modal anticoagulation showing improved outcome by >50% (P = 0...
May 21, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29781197/efficacy-and-safety-of-levetiracetam-for-migraine-prophylaxis-a-systematic-review
#7
REVIEW
A K Watkins, M E Gee, J N Brown
WHAT IS KNOWN AND OBJECTIVE: Migraine is a common and costly neurological disorder that affects approximately 1 of every 7 people annually. Pharmacological therapy for prevention of migraine is warranted when patients experience at least 6 headache days, 4 headache days with at least some impairment or 3 headache days with severe impairment or requiring bed rest in a month. Levetiracetam is an antiepileptic drug that has the potential to be beneficial for migraine prophylaxis. The objective of this review was to assess the safety and efficacy of levetiracetam for migraine prophylaxis...
May 20, 2018: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29781075/effectiveness-of-gabapentin-pharmacotherapy-in-chemotherapy-induced-peripheral-neuropathy
#8
Magdalena Magnowska, Natalia Iżycka, Joanna Kapoła-Czyż, Anna Romała, Jakub Lorek, Marek Spaczyński, Ewa Nowak-Markwitz
OBJECTIVES: Chemotherapy-induced peripheral neuropathy (CIPN) is a common chemotherapy side effect, but its prevention and treatment remains a challenge. Neurotoxicity may lead to dose limitation or even treatment discontinuation, and therefore potentially affect the efficacy of anticancer treatment and long term outcomes. The practice to administer gabapentin for neuropathy may be applicable, but is limited by insufficient studies. The aim of our study was to assess the presence of chemotherapy-induced peripheral neuropathy in ovarian cancer patients treated with first-line paclitaxel and carboplatin chemotherapy and evaluate the effectiveness of gabapentin in treatment of this condition...
2018: Ginekologia Polska
https://www.readbyqxmd.com/read/29780293/serial-changes-of-cytokines-in-children-with-cerebral-palsy-who-received-intravenous-granulocyte-colony-stimulating-factor-followed-by-autologous-mobilized-peripheral-blood-mononuclear-cells
#9
Hani Koh, Wee-Jin Rah, Yong-Joo Kim, Jin-Hwa Moon, Mi-Jung Kim, Young-Ho Lee
Background: This study was performed to assess serial cytokine changes and their clinical impact in children with cerebral palsy (CP) who received granulocyte-colony stimulating factor (G-CSF) followed by infusion of autologous mobilized peripheral blood mononuclear cells (mPBMCs). Methods: Peripheral blood (PB) samples were collected from 16 CP children at enrollment, and 1 month and 7 months after G-CSF infusion as well as at the end of the study. Cytokine levels were measured by enzyme-linked immunosorbent assays with plasma samples...
May 21, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29780231/predictors-of-shunt-dependent-hydrocephalus-following-aneurysmal-subarachnoid-hemorrhage-a-pilot-study-in-a-single-egyptian-institute
#10
Hashem M Aboul-Ela, Ahmed M Salah El-Din, Ahmed A Zaater, Mohamed Shehab, Ossama A El Shahawy
Background: Acute hydrocephalus can cause neurological deterioration after aneurysmal subarachnoid hemorrhage (aSAH). Predicting which patient would require shunting is challenging. Methods: This prospective study was conducted upon twenty patients who suffered acute hydrocephalus due to subarachnoid hemorrhage of ruptured aneurysms. Surgical or non-surgical management of hydrocephalus was conducted. Glasgow Coma scale (GCS) was assessed, and hydrocephalus was graded by bicaudate index...
2018: Egypt J Neurol Psychiatr Neurosurg
https://www.readbyqxmd.com/read/29780226/cerebral-border-zone-infarction-an-etiological-study
#11
Tarek Mohammed El-Gammal, Wafik Said Bahnasy, Osama Abd Allah Ragab, Ayman Mohammed Al-Malt
Background: Border zone infarcts (BZI) are ischemic lesions at the junction between two main arterial territories which may be either cortical or internal BZI. Methods: This study was conducted on 76 cerebral BZI patients and 20 healthy control subjects. Patients were divided to group I included 26 internal BZI, group II included 19 cortical BZI and group III included 21 mixed internal/cortical BZI patients. Included subjects were submitted to neurological examination, laboratory investigations, ECG, echocardiogram, brain CT and/or MRI and extra and intracranial blood vessels imaging by duplex and CT angiography...
2018: Egypt J Neurol Psychiatr Neurosurg
https://www.readbyqxmd.com/read/29780224/correlative-study-between-c-reactive-protein-clinical-severity-and-nerve-conduction-studies-in-guillain-barr%C3%A3-syndrome
#12
Yosria A Altaweel, Sawsan Abdelaziz, Hala A Fathy, Shimaa AbdelBadea
Background: Guillain-Barre' syndrome (GBS) is a serious autoimmune disorder in which the immune system attacks healthy nerve cells of the peripheral nervous system causing polyradiculoneuropathy which leads to weakness, numbness, and tingling, and can eventually cause paralysis. Autoimmune conditions like GBS can induce a high level of inflammation resulting in an increase in the C-reactive protein( CRP) production. The aim of this study is to assess the relationship between CRP level and the clinical severity as well as the electrophysiological findings of nerve conduction studies in patients with GBS...
2018: Egypt J Neurol Psychiatr Neurosurg
https://www.readbyqxmd.com/read/29779968/one-stage-posterior-debridement-and-fusion-combined-with-irrigation-and-drainage-for-the-treatment-of-postoperative-lumbar-spondylodiscitis
#13
Tao Zhang, Jianzhong Hu, Jianhuang Wu, Jinyang Liu, Shuangfei Ni, Chunyue Duan
OBJECTIVE: The aim of this study was to evaluate the clinical outcomes of one-stage posterior debridement, interbody fusion, and instrumentation, combined with irrigation and drainage, for treating lumbar spondylodiscitis. METHODS: The study included 23 patients (13 male and 10 female, mean age: 45 years) who had posterior debridement, interbody fusion, and instrumentation, followed by continuous closed irrigation and drainage for lumbar postoperative spondylodiscitis...
May 17, 2018: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/29778535/lysophosphatidic-acid-receptor-lpa-6-regulates-endothelial-blood-brain-barrier-function-implication-of-hepatic-encephalopathy
#14
Kayo Masago, Yasuyuki Kihara, Keisuke Yanagida, Fumie Hamano, Shinsuke Nakagawa, Masami Niwa, Takao Shimizu
Cerebral edema is a life-threatening neurological condition characterized by brain swelling due to accumulation of excess fluid both intracellularly and extracellularly. Fulminant hepatic failure (FHF) develops cerebral edema by disrupting blood brain barrier (BBB). However, the mechanisms by which mediator induces brain edema in FHF remain to be elucidated. Here, we assessed a linkage between brain edema and lysophosphatidic acid (LPA) signaling by utilizing an animal model of FHF and in vitro BBB model. Azoxymethane-treated mice developed FHF and hepatic encephalopathy, associated with higher autotaxin (ATX) activities in serum than controls...
May 17, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29778429/outcomes-following-severe-hand-foot-and-mouth-disease-a-systematic-review-and-meta-analysis
#15
Eben Jones, Timesh D Pillay, Fengfeng Liu, Li Luo, Juan Carlos Bazo-Alvarez, Chen Yuan, Shanlu Zhao, Qi Chen, Yu Li, Qiaohong Liao, Hongjie Yu, H Rogier van Doorn, Saraswathy Sabanathan
BACKGROUND: Hand, foot and mouth disease (HFMD) caused by enterovirus A71 (EV-A71) is associated with acute neurological disease in children. This study aimed to estimate the burden of long-term sequelae and death following severe HFMD. METHODS: This systematic review and meta-analysis pooled all reports from English and Chinese databases including MEDLINE and Wangfang on outbreaks of clinically diagnosed HFMD and/or laboratory-confirmed EV-A71 with at least 7 days' follow-up published between 1st January 1966 and 19th October 2015...
April 20, 2018: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/29778327/an-unusual-etiology-of-vocal-tremor-in-a-professional-singer
#16
REVIEW
Bridget L Hopewell, Cristen Paige, David O Francis
Vocal tremor is a neurologic disorder with myriad etiologies (eg, Parkinson disease, medications, or essential tremor). Vocal tremor can limit intelligibility and social interaction and can result in isolation in nonprofessional voice users. In a professional singer whose entire career is based on voice quality, onset of a vocal tremor is devastating. We report a case of sudden-onset vocal tremor that impeded a young professional singer's ability to perform and record her album. The etiology was determined to be a medication side effect of lamotrigine; a reaction that has not been previously reported...
May 16, 2018: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/29778030/retrospective-genotype-phenotype-analysis-in-a-305-patient-cohort-referred-for-testing-of-a-targeted-epilepsy-panel
#17
Andrew N Hesse, Jennifer Bevilacqua, Kritika Shankar, Honey V Reddi
PURPOSE: Epilepsy is a diverse neurological condition with extreme genetic and phenotypic heterogeneity. The introduction of next-generation sequencing into the clinical laboratory has made it possible to investigate hundreds of associated genes simultaneously for a patient, even in the absence of a clearly defined syndrome. This has resulted in the detection of rare and novel mutations at a rate well beyond our ability to characterize their effects. This retrospective study reviews genotype data in the context of available phenotypic information on 305 patients spanning the epileptic spectrum to identify established and novel patterns of correlation...
May 16, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29777940/curcumin-attenuates-cerebral-ischemia-injury-in-sprague-dawley-rats-and-pc12-cells-by-suppressing-overactivated-autophagy
#18
Yan Zhang, Ming Fang, Yameng Sun, Ting Zhang, Nan Shi, Jinfeng Li, Lei Jin, Kangyong Liu, Jianliang Fu
The present study assessed whether the protective effects of curcumin against cerebral ischemia injury were due to the suppression of overactivated autophagy. Curcumin is a well-known natural polyphenolic compound that effectively counteracts oxidation, inflammation, and various types of cancer. Several studies have demonstrated the protective effects of curcumin against ischemia-reperfusion injury in tissues from the lungs, cardiomyocytes, and liver. The present study employed brain injury models induced by middle cerebral artery occlusion (MCAO) in rats and PC12 oxygen-glucose-deprived (OGD) cells...
May 7, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29777886/stereotactic-radiosurgery-for-high-grade-intracranial-dural-arteriovenous-fistulas
#19
Ching-Jen Chen, Thomas J Buell, Joshua Diamond, Dale Ding, Jeyan S Kumar, Davis G Taylor, Cheng-Chia Lee, Jason P Sheehan
OBJECTIVE: Factors associated with favorable outcome following stereotactic radiosurgery (SRS) for dural arteriovenous fistulas (DAVFs) with cortical venous reflux (CVR) are incompletely understood. The aim of this retrospective cohort study is to assess the outcomes after SRS for high-grade DAVFs and identify predictors. METHODS: We performed a retrospective review of consecutive patients with high-grade DAVFs, defined as the presence of CVR, who underwent SRS between 1989 and 2017...
May 16, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29777884/neurosurgical-management-of-self-inflicted-cranial-crossbow-injury
#20
Charles G Kulwin, Andrew DeNardo, Saad Khairi, Troy Payner
BACKGROUND: While gun-related penetrating traumatic brain injuries make up the majority of cranial missile injuries, low-velocity penetrating injuries present significant clinical difficulties that cannot necessarily be identically managed. Bow hunting is an increasingly popular pastime, and a crossbow allows a unique mechanism to cause a self-inflicted cranial injury with a large, low-velocity projectile. Historically, arrow removal is described in an operating room setting, which provides limited knowledge of the location of vascular injury in the setting of post-removal hemorrhage, and may represent an inefficient use of operating room availability...
May 16, 2018: World Neurosurgery
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