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https://www.readbyqxmd.com/read/29057688/rock-as-a-therapeutic-target-for-ischemic-stroke
#1
Nikola Sladojevic, Brian Yu, James K Liao
Stroke is a major cause of disability and the fifth leading cause of death. Currently, the only approved acute medical treatment of ischemic stroke is tissue plasminogen activator (tPA), but its effectiveness is greatly predicated upon early administration of the drug. There is, therefore, an urgent need to find new therapeutic options for acute stroke. Areas covered: In this review, we summarize the role of Rho-associated coiled-coil containing kinase (ROCK) and its potential as a therapeutic target in stroke pathophysiology...
October 23, 2017: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/29057550/in-vitro-magnetic-resonance-imaging-evaluation-of-fragmented-open-coil-percutaneous-peripheral-nerve-stimulation-leads
#2
Frank G Shellock, Armaan Zare, Brian M Ilfeld, John Chae, Robert B Strother
OBJECTIVE: Percutaneous peripheral nerve stimulation (PNS) is an FDA-cleared pain treatment. Occasionally, fragments of the lead (MicroLead, SPR Therapeutics, LLC, Cleveland, OH, USA) may be retained following lead removal. Since the lead is metallic, there are associated magnetic resonance imaging (MRI) risks. Therefore, the objective of this investigation was to evaluate MRI-related issues (i.e., magnetic field interactions, heating, and artifacts) for various lead fragments. METHODS: Testing was conducted using standardized techniques on lead fragments of different lengths (i...
October 23, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29057414/salt-induced-thermochromism-of-a-conjugated-polyelectrolyte
#3
Lisa Peterhans, Elisa Alloa, Yauhen Sheima, Laurent Vannay, Mario Leclerc, Clémence Corminboeuf, Sophia C Hayes, Natalie Banerji
We report here the photophysical properties of a water-soluble conjugated polythiophene with cationic side-chains. When dissolved in aqueous buffer solution (PBS, phosphate buffered saline), there is ordering of the polymer chains due to the presence of the salts, in contrast to pure water, where a random-coil conformation is adopted at room temperature. The ordering leads to a pronounced colour change of the solution (the absorption maximum shifts from 400 nm to 525 nm). Combining resonance Raman spectroscopy with density functional theory computations, we show a significant backbone planarization in the ordered phase...
October 23, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29056483/structure-and-misfolding-of-the-flexible-tripartite-coiled-coil-domain-of-glaucoma-associated-myocilin
#4
Shannon E Hill, Elaine Nguyen, Rebecca K Donegan, Athéna C Patterson-Orazem, Anthony Hazel, James C Gumbart, Raquel L Lieberman
Glaucoma-associated myocilin is a member of the olfactomedins, a protein family involved in neuronal development and human diseases. Molecular studies of the myocilin N-terminal coiled coil demonstrate a unique tripartite architecture: a Y-shaped parallel dimer-of-dimers with distinct tetramer and dimer regions. The structure of the dimeric C-terminal 7-heptad repeats elucidates an unexpected repeat pattern involving inter-strand stabilization by oppositely charged residues. Molecular dynamics simulations reveal an alternate accessible conformation in which the terminal inter-strand disulfide limits the extent of unfolding and results in a kinked configuration...
October 12, 2017: Structure
https://www.readbyqxmd.com/read/29056256/glibenclamide-inhibits-nlrp3-inflammasome-mediated-il-1%C3%AE-secretion-in-human-trophoblasts
#5
Kazuhiro Tamura, Gen Ishikawa, Mikihiro Yoshie, Wakana Ohneda, Akihito Nakai, Toshiyuki Takeshita, Eiichi Tachikawa
Infection-associated pregnancy complications cause premature delivery. Caspase-1 is involved in the maturation of interleukin (IL)-1β, which is activated by the NLRP3 inflammasome. To characterize the significance of the NLRP3 inflammasome pathway in the placenta, the effects of activators and inhibitors on NLRP3-related molecules were examined using isolated primary trophoblasts. Caspase-1 and IL-1β mRNA expression was markedly increased in response to lipopolysaccharide (LPS), a toll-like receptor (TLR)4 ligand...
October 6, 2017: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/29055853/morphology-and-phylogeny-of-ameson-portunus-n-sp-microsporidia-infecting-the-swimming-crab-portunus-trituberculatus-from-china
#6
Yuan Wang, Xin-Cang Li, Guihong Fu, Shu Zhao, Yuange Chen, Hao Wang, Tiantian Chen, Junfang Zhou, Wenhong Fang
Ameson portunus n. sp. is a new microsporidian species that infects the skeletal muscle of Portunus trituberculatus, a pond-reared swimming crab from China. This parasite was characterized using morphological and molecular phylogenetic data. Light and transmission electron microscopy revealed that this microsporidian experienced disporogonic and polysporogonic (chain-like) life cycles. Mature uninucleate spores appeared ovoid, measured 1.4±0.06×1.0±0.07μm on ultrathin sections, and exhibited no dimorphism...
September 27, 2017: European Journal of Protistology
https://www.readbyqxmd.com/read/29054956/indirect-carotid-cavernous-fistula-mimicking-ocular-myasthenia
#7
Lakshmi Leishangthem, Sudhakar Reddy Satti
71-year-old woman with progressive left-sided, monocular diplopia and ptosis. Her symptoms mimicked ocular myasthenia, but she had an indirect carotid cavernous fistula (CCF). She was diagnosed with monocular myasthenia gravis (negative acetylcholinesterase antibody) after a positive ice test and started on Mestinon and underwent a thymectomy complicated by a brachial plexus injury. Months later, she developed left-sided proptosis and ocular bruit. She was urgently referred to neuro-interventional surgery and was diagnosed with an indirect high-flow left CCF, which was treated with Onyx liquid and platinum coil embolisation...
October 19, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29054773/microsurgical-vs-endovascular-treatments-for-blood-blister-aneurysms-of-the-internal-carotid-artery-a-retrospective-study-of-83-patients-in-a-single-center
#8
Yanming Ren, Lunxin Liu, Hong Sun, Yi Liu, Hao Li, Lu Ma, Chang-Wei Zhang, Xiao-Dong Xie, Min He, Chao You, Jin Li
BACKGROUND: Blood-blister aneurysms (BBAs) of the internal carotid artery (ICA) are challenging lesions with high morbidity and mortality. Currently, both surgical and endovascular approaches have been used to treat the BBAs; however, little is known about their safety and efficacy. OBJECTIVE: To review our experience with the treatment of BBAs and explore the optimal treatment strategy. METHODS: A total of 83 patients with BBAs were reviewed retrospectively...
October 17, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29053913/morphological-changes-of-the-internal-carotid-artery-prevalence-and-characteristics-a-clinic-and-ultrasonographic-study-in-a-series-of-19-804-patients-over-25-years-old
#9
Hugo F G Martins, Alexandra Mayer, Paulo Batista, Fátima Soares, Vanessa Almeida, Ana Júlia Pedro, Victor Oliveira
BACKGROUND: Morphological changes of the internal carotid arteries (McICA) are frequently found during cervical ultrasound studies. However, McICA's etiology remains controversial. During this study, the prevalence and demographic characteristics of McICA such as kinking, coiling or looping, identified by Doppler ultrasound, were analysed and its relationship with vascular risk factors and stroke was assessed. METHODS: A retrospective study was performed by analysing 19,804 patients between Jan 2000 and Jun 2012 who were submitted to cervical ultrasonographic study...
October 20, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29053449/thermo-acoustic-ultrasound-for-detection-of-rf-induced-device-lead-heating-in-mri
#10
Neerav Dixit, Pascal P Stang, John M Pauly, Greig C Scott
Patients who have implanted medical devices with long conductive leads are often restricted from receiving MRI scans due to the danger of RF-induced heating near the lead tips. Phantom studies have shown that this heating varies significantly on a case-by-case basis, indicating that many patients with implanted devices can receive clinically useful MRI scans without harm. However, the difficulty of predicting RF-induced lead tip heating prior to scanning prevents numerous implant recipients from being scanned...
October 17, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/29053444/an-em-simulation-based-design-flow-for-custom-built-mr-coils-incorporating-signal-and-noise
#11
Andreas Horneff, Michael Eder, Erich Hell, Johannes Ulrici, Jorg Felder, Volker Rasche, Jens Anders
Developing custom-built MR coils is a cumbersome task, in which an a priori prediction of the coils' SNR performance, their sensitivity pattern and their depth of penetration helps to greatly speed up the design process by reducing the required hardware manufacturing iterations. The simulationbased design flow presented in this paper takes the entire MR imaging process into account. That is, it includes all geometric and material properties of the coil and the phantom, the thermal noise as well as the target MR sequences...
October 17, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/29053074/clinical-improvement-associated-with-targeted-interruption-of-the-cerebellothalamic-tract-following-mr-guided-focused-ultrasound-for-essential-tremor
#12
J Levi Chazen, Harini Sarva, Philip E Stieg, Robert J Min, Douglas J Ballon, Kane O Pryor, Paul M Riegelhaupt, Michael G Kaplitt
OBJECTIVE The objective of this study was to evaluate the utility of diffusion tensor imaging (DTI) tractography-based targeting of the dentatorubrothalamic tract (DRT) for magnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy in patients with essential tremor (ET) and correlate postprocedural tract disruption with clinical outcomes. METHODS Four patients received preprocedural and immediate postprocedural DTI in addition to traditional anatomical MRI sequences for MRgFUS thalamotomy. Optimal ablation sites were selected based on the patient-specific location of the DRT as demonstrated by DTI (direct targeting) and correlated with traditional atlas-based measurements for thalamic ventral intermediate nucleus (Vim) lesioning (indirect targeting)...
October 20, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29053070/relationship-between-patient-safety-indicator-events-and-comprehensive-stroke-center-volume-status-in-the-treatment-of-unruptured-cerebral-aneurysms
#13
Chad W Washington, L Ian Taylor, Robert J Dambrino, Paul R Clark, Gregory J Zipfel
OBJECTIVE The Agency of Healthcare Research and Quality (AHRQ) has defined Patient Safety Indicators (PSIs) for assessments in quality of inpatient care. The hypothesis of this study is that, in the treatment of unruptured cerebral aneurysms (UCAs), PSI events are less likely to occur in hospitals meeting the volume thresholds defined by The Joint Commission for Comprehensive Stroke Center (CSC) certification. METHODS Using the 2002-2011 National (Nationwide) Inpatient Sample, patients treated electively for a nonruptured cerebral aneurysm were selected...
October 20, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29053032/a-mouse-model-of-subcortical-vascular-dementia-reflecting-degeneration-of-cerebral-white-matter-and-microcirculation
#14
Eek-Sung Lee, Jin-Hui Yoon, Jiye Choi, Faris R Andika, Taekwan Lee, Yong Jeong
Subcortical vascular dementia(SVaD) is associated with white matter damage, lacunar infarction, and degeneration of cerebral microcirculation. Currently available mouse models can mimic only partial aspects of human SVaD features. Here, we combined bilateral common carotid artery stenosis (BCAS) with a hyperlipidaemia model in order to develop a mouse model of SVaD; 10- to 12-week-old apolipoprotein E (ApoE)-deficient or wild-type C57BL/6J mice were subjected to sham operation or chronic cerebral hypoperfusion with BCAS using micro-coils...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29052976/engineering-enhanced-pore-sizes-using-fhua-%C3%AE-1-160-from-e-coli-outer-membrane-as-template
#15
Zhanzhi Liu, Ishan Ghai, Mathias Winterhalter, Ulrich Schwaneberg
Biological membranes are the perfect example of a molecular filter using membrane channels to control the permeability of small water-soluble molecules. To allow filtering of larger hydrophilic molecules we started from the known mutant channel FhuA Δ1-160 in which the ´´cork´´ domain closing the channel had been removed. Here we further expand the pore diameter by copying the amino acid sequence of two ß-strands in a step-wise manner increasing the total number of ß-strands from 22 to 34. The pore size of the respective expanded channel protein was characterized by single-channel conductance...
October 20, 2017: ACS Sensors
https://www.readbyqxmd.com/read/29052912/clinicopathologic-significance-of-rock2-expression-in-oral-squamous-cell-carcinomas
#16
Mauricio Rocha Dourado, Carine Ervolino de Oliveira, Iris Sawazaki-Calone, Elias Sundquist, Ricardo D Coletta, Tuula Salo
BACKGROUND: Rho-associated coiled-coil kinase 2 (ROCK2) is an oncoprotein that controls cytoskeleton organization and acts as prognostic marker in different types of solid tumors. ROCK2 overexpression is also observed in cancer-associated fibroblasts (CAF), which suggests its relevance within the tumor microenvironment. This study aimed to access the prognostic value of ROCK2 in oral squamous cell carcinomas (OSCC) and its association with CAF density. METHODS: ROCK2 immunohistochemical analysis was applied in 93 OSCC samples from 2 centers in Brazil and Finland...
October 20, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29051205/two-center-experience-in-the-endovascular-treatment-of-ruptured-and-unruptured-intracranial-aneurysms-using-the-web-device-a-retrospective-analysis
#17
J Popielski, A Berlis, W Weber, S Fischer
BACKGROUND AND PURPOSE: The safety and efficacy of the Woven EndoBridge (WEB) device for the treatment of cerebral aneurysms has been investigated in several studies. Our objective was to report the experience of 2 neurovascular centers with the WEB device in the treatment of broad-based intracranial aneurysms, including the technical feasibility and safety as well as short- and midterm angiographic and clinical follow-up-results. MATERIALS AND METHODS: We performed a retrospective analysis of all ruptured and unruptured aneurysms treated with a WEB device (WEB Single-Layer and Single-Layer Sphere) between August 2014 and February 2017...
October 19, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29049750/spontaneous-intra-abdominal-haemorrhage-due-to-segmental-arterial-mediolysis-following-oesophagocolojejunostomy
#18
Jonggeun Lee, Hyo Yeong Ahn, Hoseok I, Chang Won Kim
Segmental arterial mediolysis is a rare vascular disease that leads to spontaneous intra-abdominal haemorrhage, which causes shock and bowel ischaemia, and is associated with a high mortality rate. Here, we present a case of spontaneous intra-abdominal haemorrhage due to segmental arterial mediolysis in a patient who underwent oesophagocolojejunostomy for synchronous triple primary cancer, which was treated successfully by coil embolization. We conclude that a preoperative angiogram is necessary to detect vascular abnormalities, and in cases with severe haemorrhage, an urgent endovascular procedure is the treatment of choice...
July 20, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29048583/comparative-efficacy-of-commercial-mosquito-coils-against-aedes-aegypti-diptera-culicidae-in-malaysia-a-nationwide-report
#19
A C Chin, C D Chen, V L Low, H L Lee, A A Azidah, K W Lau, M Sofian-Azirun
This study was conducted using the glass chamber method to determine the susceptibility status of the dengue vector, Aedes aegypti (L.) from 11 states in Malaysia to commercial mosquito coils containing four different active ingredients, namely metofluthrin, d-allethrin, d-trans allethrin, and prallethrin. Aedes aegypti exhibited various knockdown rates, ranging from 14.44% to 100.00%, 0.00% to 61.67%, 0.00% to 90.00%, and 0.00% to 13.33% for metofluthrin, d-allethrin, d-trans allethrin, and prallethrin, respectively...
October 1, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/29047702/symmetry-evaluation-for-an-interferometric-fiber-optic-gyro-coil-utilizing-a-bidirectional-distributed-polarization-measurement-system
#20
Feng Peng, Chuang Li, Jun Yang, Chengcheng Hou, Haoliang Zhang, Zhangjun Yu, Yonggui Yuan, Hanyang Li, Libo Yuan
We propose a dual-channel measurement system for evaluating the optical path symmetry of an interferometric fiber optic gyro (IFOG) coil. Utilizing a bidirectional distributed polarization measurement system, the forward and backward transmission performances of an IFOG coil are characterized simultaneously by just a one-time measurement. The simple but practical configuration is composed of a bidirectional Mach-Zehnder interferometer and multichannel transmission devices connected to the IFOG coil under test...
July 10, 2017: Applied Optics
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