keyword
https://read.qxmd.com/read/38523610/complications-of-oropharyngeal-dysphagia-in-older-individuals-and-patients-with-neurological-disorders-insights-from-matar%C3%A3-hospital-catalonia-spain
#21
JOURNAL ARTICLE
Tennekoon B Karunaratne, Pere Clavé, Omar Ortega
BACKGROUND: Oropharyngeal dysphagia (OD) significantly impacts older individuals and neurologically compromised patients, hindering safe ingestion of food and liquids. Despite its prevalence, OD remains underdiagnosed and undertreated, leading to severe complications such as malnutrition, dehydration, respiratory infections, and aspiration pneumonia (AP), and increases hospital readmissions. OBJECTIVES: This study analyzes the intricate relationship between OD and various clinical complications in older individuals and patients with neurological disorders...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38523419/expert-consensus-recommendations-for-improving-and-standardising-the-assessment-of-patients-with-generalised-myasthenia-gravis
#22
JOURNAL ARTICLE
Andreas Meisel, Francesco Saccà, Jennifer Spillane, John Vissing
BACKGROUND: Regular and consistent disease assessment could provide a clearer picture of burden in generalised myasthenia gravis (gMG) and improve patient care; however, the use of assessment tools in practice lacks standardisation. This modified Delphi approach was taken to review current evidence on assessment tool use in gMG and develop expert-derived consensus recommendations for good practice. METHODS: A European expert panel of 15 experienced gMG neurologists contributed to development of this consensus, four of whom formed a lead Sub-committee...
March 24, 2024: European Journal of Neurology
https://read.qxmd.com/read/38522911/the-clinical-practice-guideline-for-the-management-of-amyotrophic-lateral-sclerosis-in-japan-update-2023
#23
JOURNAL ARTICLE
Makoto Urushitani, Hitoshi Warita, Naoki Atsuta, Yuishin Izumi, Osamu Kano, Toshio Shimizu, Yuki Nakayama, Yugo Narita, Hiroyuki Nodera, Takuji Fujita, Koichi Mizoguchi, Mitsuya Morita, Masashi Aoki
Amyotrophic lateral sclerosis (ALS) is an adult-onset intractable motor neuron disease characterized by selective degeneration of cortical neurons in the frontotemporal lobe and motor neurons in the brainstem and spinal cord. Impairment of these neural networks causes progressive muscle atrophy and weakness that spreads throughout the body, resulting in life-threatening bulbar palsy and respiratory muscle paralysis. However, no therapeutic strategy has yet been established to halt ALS progression. Although evidence for clinical practice in ALS remains insufficient, novel research findings have steadily accumulated in recent years...
March 23, 2024: Rinshō Shinkeigaku, Clinical Neurology
https://read.qxmd.com/read/38522390/development-reliability-and-validity-of-the-mobility-assessment-scale-in-hospitalized-patients-hmob
#24
JOURNAL ARTICLE
Isis Resende Ramos, Joice Sousa Santos, Maria Cecilia Pires Dos Santos, Daruane Ferreira da Silva, Iura Gonzalez Nogueira Alves, Mansueto Gomes Neto, Bruno Prata Martinez
BACKGROUND: Existing mobility scales for hospitalized patients do not include assessment of tasks for the right and left side, ability to transfer from sitting to lying and from standing to sitting, ability to climbing steps and pick up an object from the floor in the same instrument. OBJECTIVE: Evaluate the reliability and validity of the hospital mobility assessment scale (HMob) according to the Consensus-based standards for the selection of health measurement instruments (COSMIN)...
March 7, 2024: Brazilian Journal of Physical Therapy
https://read.qxmd.com/read/38522245/remote-pulmonary-function-testing-allows-for-early-identification-of-need-for-non-invasive-ventilation-in-a-subset-of-persons-with-als
#25
JOURNAL ARTICLE
Andrew Geronimo, Zachary Simmons
The traditional ALS multidisciplinary clinical practice of quarterly respiratory assessment may leave some individuals in danger of developing untreated respiratory insufficiency between visits or beginning non-invasive ventilation (NIV) later than would be optimal. Remote, or home-based, pulmonary function testing (rPFT) allows patients with ALS to perform regular respiratory testing at more frequent intervals in the home. The aim of this study was to determine the clinical benefit of weekly rPFT compared to standard, quarterly in-clinic respiratory assessments: the number of individuals with earlier identification of NIV need, the magnitude of this advance notice, and the individual factors predicting benefit...
March 19, 2024: Journal of the Neurological Sciences
https://read.qxmd.com/read/38521932/cryopreservation-of-cerebrospinal-fluid-cells-preserves-the-transcriptional-landscape-for-single-cell-analysis
#26
JOURNAL ARTICLE
Mahesh Chandra Kodali, Jerry Antone, Eric Alsop, Rojashree Jayakumar, Khushi Parikh, Aude Chiot, Paula Sanchez-Molina, Bahareh Ajami, Steven E Arnold, Kendall Jensen, Sudeshna Das, Marc S Weinberg
Cerebrospinal fluid (CSF) matrix biomarkers have become increasingly valuable surrogate markers of neuropsychiatric diseases in research and clinical practice. In contrast, CSF cells have been rarely investigated due to their relative scarcity and fragility, and lack of common collection and cryopreservation protocols, with limited exceptions for neurooncology and primary immune-based diseases like multiple sclerosis. the advent of a microfluidics-based multi-omics approach to studying individual cells has allowed for the study of cellular phenotyping, intracellular dynamics, and intercellular relationships that provide multidimensionality unable to be obtained through acellular fluid-phase analyses...
March 23, 2024: Journal of Neuroinflammation
https://read.qxmd.com/read/38520645/granulocytes-in-cerebrospinal-fluid-of-adults-suspected-of-a-central-nervous-system-infection-a-prospective-study-of-diagnostic-accuracy
#27
JOURNAL ARTICLE
Steven L Staal, Sabine E Olie, Liora Ter Horst, Ingeborg E van Zeggeren, Diederik van de Beek, Matthijs C Brouwer
PURPOSE: Cerebrospinal fluid (CSF) granulocytes are associated with bacterial meningitis, but information on its diagnostic value is limited and primarily based on retrospective studies. Therefore, we assessed the diagnostic accuracy of CSF granulocytes. METHODS: We analyzed CSF granulocytes (index test) from all consecutive patients in two prospective cohort studies in the Netherlands. Both studies included patients ≥ 16 years, suspected of a central nervous system (CNS) infection, who underwent a diagnostic lumbar puncture...
March 23, 2024: Infection
https://read.qxmd.com/read/38520381/digital-neuropsychology-beyond-computerized-cognitive-assessment-applications-of-novel-digital-technologies
#28
JOURNAL ARTICLE
Che Harris, Yingfei Tang, Eliana Birnbaum, Christine Cherian, Dinesh Mendhe, Michelle H Chen
Compared with other health disciplines, there is a stagnation in technological innovation in the field of clinical neuropsychology. Traditional paper-and-pencil tests have a number of shortcomings, such as low-frequency data collection and limitations in ecological validity. While computerized cognitive assessment may help overcome some of these issues, current computerized paradigms do not address the majority of these limitations. In this paper, we review recent literature on the applications of novel digital health approaches, including ecological momentary assessment, smartphone-based assessment and sensors, wearable devices, passive driving sensors, smart homes, voice biomarkers, and electronic health record mining, in neurological populations...
March 22, 2024: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://read.qxmd.com/read/38519849/an-individualized-yoga-intervention-for-people-with-functional-neurological-disorder-case-series
#29
JOURNAL ARTICLE
Danielle Kipnis, Sally Leung, Abigail R Schreier, Kimberly Kwei, Hiral Shah, Lori Quinn
Functional neurological disorder (FND) is a heterogeneous condition of neurological symptoms that cannot be linked to a specific neurological cause. Yoga combines movement, breathing, and meditation and has established mind-body effects for people who are managing both psychological and neurological conditions. This case series describes key components of a yoga program for people with FND, evaluating feasibility, acceptability, and efficacy via self-report surveys, clinical assessments, and postintervention interview...
March 1, 2024: International Journal of Yoga Therapy
https://read.qxmd.com/read/38518925/abnormal-brachial-plexus-differentiation-from-routine-magnetic-resonance-imaging-an-ai-based-approach
#30
JOURNAL ARTICLE
Weiguo Cao, Benjamin M Howe, Darryl E Wright, Sumana Ramanathan, Nicholas G Rhodes, Panagiotis Korfiatis, Kimberly K Amrami, Robert J Spinner, Timothy L Kline
Automatic abnormality identification of brachial plexus (BP) from normal magnetic resonance imaging to localize and identify a neurologic injury in clinical practice (MRI) is still a novel topic in brachial plexopathy. This study developed and evaluated an approach to differentiate abnormal BP with artificial intelligence (AI) over three commonly used MRI sequences, i.e. T1, FLUID sensitive and post-gadolinium sequences. A BP dataset was collected by radiological experts and a semi-supervised artificial intelligence method was used to segment the BP (based on nnU-net)...
March 20, 2024: Neuroscience
https://read.qxmd.com/read/38518279/language-discordant-care-in-pediatric-neurosurgery-parent-and-provider-perspectives-on-challenges-and-multilevel-solutions-to-reduce-disparities
#31
JOURNAL ARTICLE
Gabriela D Ruiz Colón, Sylvia Bereknyei Merrell, Diana C Poon, Kelly B Mahaney, Cormac O Maher, Laura M Prolo
OBJECTIVE: In the United States, Spanish is the second most spoken language, with nearly 42 million individuals speaking Spanish at home. Spanish speakers have been noted to have higher rates of unfavorable neurosurgical outcomes; however, to the authors' knowledge, no study has explored the experiences of patients, caregivers, and providers receiving or delivering neurosurgical care in language-discordant settings. In this study, the authors sought to identify challenges faced by pediatric neurosurgery providers and Spanish-speaking parents communicating with a language barrier and propose solutions to address those challenges...
March 22, 2024: Journal of Neurosurgery. Pediatrics
https://read.qxmd.com/read/38517685/the-impact-of-refined-nursing-intervention-on-neurological-function-recovery-and-prognosis-improvement-in-patients-undergoing-intracranial-aneurysm-intervention
#32
JOURNAL ARTICLE
Wenfang Ma, Shixing Li, Xiuhua Wang, Zukuan Chang, Jing Ma
BACKGROUND: This study aims to explore the application of refined nursing intervention in patients undergoing unruptured intracranial aneurysm intervention, evaluating its impact on neurological function recovery and prognosis improvement. METHODS: Patients diagnosed with intracranial aneurysms and undergoing treatment at our hospital from February 2022 to June 2023 were included in this study. After applying complete inclusion and exclusion criteria to ensure sample representativeness, a total of 92 patients were enrolled...
March 22, 2024: International Journal of Neuroscience
https://read.qxmd.com/read/38517586/the-role-of-123-i-mibg-cardiac-scintigraphy-in-the-differential-diagnosis-between-dementia-with-lewy-bodies-and-alzheimer-s-disease
#33
REVIEW
Giacomo Monzio Compagnoni, Ildebrando Appollonio, Carlo Ferrarese
Although detailed diagnostic guidelines are available, differentiating dementia with Lewy bodies from Alzheimer's disease is often difficult. 123-I-MIBG cardiac scintigraphy is one of the tools which have been proposed for the diagnostic procedure. The present review is aimed at evaluating the available literature about this topic. Studies assessing the use of this technique to differentiate between the two diseases have been examined and reported. Overall, despite a certain study-to-study variability, the available literature suggests that 123-I-MIBG cardiac scintigraphy is an effective tool in differentiating between the two diseases, with high sensitivity and specificity values...
March 22, 2024: Neurological Sciences
https://read.qxmd.com/read/38516474/fluoroquinolones-neurological-complications-and-side-effects-in-clinical-practice
#34
REVIEW
Ahmed I Anwar, Lei Lu, Connor J Plaisance, Charles P Daniel, Chelsi J Flanagan, Danielle M Wenger, David McGregor, Giustino Varrassi, Adam M Kaye, Shahab Ahmadzadeh, Elyse M Cornett, Sahar Shekoohi, Alan D Kaye
Fluoroquinolones, a popular antibiotic class that inhibits nucleic acid synthesis of bacteria by disrupting the activity of the enzyme's topoisomerase IV and DNA gyrase, are used to treat bacterial infections. However, the widespread use of these drugs has allowed for the development of microbial resistance in recent years. Quinolones also have many clinically relevant side effects, including psychosis, confusion, seizures, headaches, dizziness, and nausea. Common side effects include tendinitis, myopathy, depression, and fatigue...
February 2024: Curēus
https://read.qxmd.com/read/38516342/an-improvement-project-in-reducing-after-visit-phone-calls-in-a-community-pediatric-neurology-clinic-too-much-communication
#35
JOURNAL ARTICLE
Thara R Bala
BACKGROUND AND OBJECTIVE: Physicians strive to provide high-quality clinical care, yet after-visit patient telephone calls create extra demands on a clinician's time. Pediatric neurologists are particularly affected by this challenge given the number of patients with chronic illnesses they serve and the volume of worried parents they support. Added workload coupled with a busy office practice increases the likelihood of early physician burnout, which can have downstream effects on the quality of patient care and patient satisfaction...
April 2024: Neurology. Clinical Practice
https://read.qxmd.com/read/38515838/pharmacological-effects-and-target-analysis-of-guipi-wan-in-the-treatment-of-cerebral-ischemia-reperfusion-injury
#36
JOURNAL ARTICLE
Jianfeng Zhang, Li Luo, Yanyan Guo, An Liu, Mengjia Zhang, Wei Jiang, Xi Li, Qingqing Liu, Jiaoyan Yu
Guipi wan (GPW) is a traditional Chinese medicine commonly used in clinical practice, typically to treat neurological diseases such as neurasthenia and traumatic brain injury. It may have positive effects on cerebral ischemia‒reperfusion injury (cI/R). This study aimed to assess the effects of GPW in a mouse model of cI/R and find its possible targets. C57BL/6J mice were used to establish the cI/R model, and the laser speckle doppler was used to determine the success of the model. GPW was administered intragastrically for 7 days, brain tissue sections were stained with TTC, HE, and TUNEL, Western blot assay was performed to detect the effect of apoptosis-related proteins...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38515429/misdiagnosis-of-functional-neurological-symptom-disorders-in-paediatrics-narrative-review-and-relevant-case-report
#37
JOURNAL ARTICLE
Valentina Baglioni, Dario Esposito, Katerina Bernardi, Maria Novelli, Valerio Zaccaria, Serena Galosi, Francesco Pisani
Functional neurological symptom disorders (FNSD) pose a common challenge in clinical practice, particularly in pediatric cases where the clinical phenotypes can be intricate and easily confused with structural disturbances. The frequent coexistence of FNSDs with other medical disorders often results in misdiagnosis. In this review, we highlight the distinctions between FNSD and various psychiatric and neurological conditions. Contrary to the misconception that FNSD is a diagnosis of exclusion, we underscore its nature as a diagnosis of inclusion, contingent upon recognizing specific clinical features...
March 22, 2024: Clinical Child Psychology and Psychiatry
https://read.qxmd.com/read/38514090/large-single-center-experience-with-short-term-follow-up-of-neqstent-assisted-coiling
#38
JOURNAL ARTICLE
Fathallah Ismail Islim, Nayyar Saleem, Tufail Patankar
BACKGROUND AND PURPOSE: Endovascular treatment of wide-neck bifurcation aneurysms has historically proved difficult with variable outcomes. Different endovascular techniques such as balloon-assisted coiling, stent-assisted coiling, or intrasaccular devices provide a varied range of efficacy and safety. Neqstent-assisted coiling is a new device and technique that aim to provide a maximum of both. We analyzed the early clinical and radiologic outcomes after the use of this new technique and device in our practice...
March 21, 2024: AJNR. American Journal of Neuroradiology
https://read.qxmd.com/read/38514034/triglyceride-glucose-index-and-prognosis-of-patients-with-subarachnoid-hemorrhage
#39
JOURNAL ARTICLE
Zhijie Xie, Jun Wang, Suijun Zhu, Min Zhang, Xuan Lv
OBJECTIVE: The triglyceride glucose index (TyG) is regarded as a reliable alternative indicator for measuring insulin resistance. We investigated the association between the prognosis of SAH patients and the TyG, explored the potential of the TyG as a new biomarker for forecasting the outcomes of SAH patients, explored independent risk factors for predicting the condition of SAH patients. METHOD: A retrospective analysis was carried out to look into the patients who were admitted to the first Linping District People's Hospital because of subarachnoid hemorrhage from January 1, 2021 to December 1, 2023...
March 19, 2024: World Neurosurgery
https://read.qxmd.com/read/38512735/performance-of-the-action-observation-based-brain-computer-interface-in-stroke-patients-and-gaze-metrics-analysis
#40
JOURNAL ARTICLE
Xin Zhang, Lin He, Qiang Gao, Ning Jiang
Brain-computer interfaces (BCIs) are anticipated to improve the efficacy of rehabilitation for people with motor disabilities. However, applying BCI in clinical practice is still a challenge due to the great diversity of patients. In the current study, a novel action observation (AO) based BCI was proposed and tested on stroke patients. Ten non-hemineglect patients and ten hemineglect patients were recruited. Four AO stimuli were designed, each presenting a decomposed action to complete the reach-and-grasp task...
March 21, 2024: IEEE Transactions on Neural Systems and Rehabilitation Engineering
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