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Ebola vaccine

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https://www.readbyqxmd.com/read/28207078/emerging-infectious-diseases-animals-and-future-epidemics
#1
Herbert L DuPont
Emerging and reemerging infections have become prevalent in the United States since the 1970s, causing illness, death, and fear among the public. The published literature was reviewed to offer a perspective on risk factors for disease acquisition and to allow a prediction of the next microbial assault after Ebola and Zika. Four well-integrated factors likely will contribute simultaneously: animals colonized or infected by pathogens capable of human transmission, microbes recurrently changing their virulence, a growing number of susceptible people, and climatic and environmental factors encouraging disease transmission...
February 1, 2017: Texas Medicine
https://www.readbyqxmd.com/read/28193382/persistence-of-immune-responses-induced-by-ebola-virus-vaccines
#2
Matthew D Snape
No abstract text is available yet for this article.
March 2017: Lancet Global Health
https://www.readbyqxmd.com/read/28187911/what-kaplan-meier-survival-curves-don-t-tell-us-about-cns-disease
#3
Katelyn D Miller, Glenn F Rall
Central nervous system consequences of viral infections are rare, but when they do occur, they are often serious and clinically challenging to manage. Our awareness of the perils of neuroinvasion by viruses is growing: the recently appreciated impact of Ebola and Zika virus infections on CNS integrity, decreases in vaccination coverage for potentially neurotropic viruses such as measles, and increased neurovirulence of some influenza strains collectively highlight the need for a better understanding of the viral-neural interaction...
February 3, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/28185595/exploring-pathways-for-building-trust-in-vaccination-and-strengthening-health-system-resilience
#4
Sachiko Ozawa, Ligia Paina, Mary Qiu
BACKGROUND: Trust is critical to generate and maintain demand for vaccines in low and middle income countries. However, there is little documentation on how health system insufficiencies affect trust in vaccination and the process of re-building trust once it has been compromised. We reflect on how disruptions to immunizations systems can affect trust in vaccination and can compromise vaccine utilization. We then explore key pathways for overcoming system vulnerabilities in order to restore trust, to strengthen the resilience of health systems and communities, and to promote vaccine utilization...
November 15, 2016: BMC Health Services Research
https://www.readbyqxmd.com/read/28179007/global-research-trends-of-world-health-organization-s-top-eight-emerging-pathogens
#5
Waleed M Sweileh
BACKGROUND: On December 8(th), 2015, World Health Organization published a priority list of eight pathogens expected to cause severe outbreaks in the near future. To better understand global research trends and characteristics of publications on these emerging pathogens, we carried out this bibliometric study hoping to contribute to global awareness and preparedness toward this topic. METHOD: Scopus database was searched for the following pathogens/infectious diseases: Ebola, Marburg, Lassa, Rift valley, Crimean-Congo, Nipah, Middle Eastern Respiratory Syndrome (MERS), and Severe Respiratory Acute Syndrome (SARS)...
February 8, 2017: Globalization and Health
https://www.readbyqxmd.com/read/28170379/corrigendum-human-antibody-repertoire-after-vsv-ebola-vaccination-identifies-novel-targets-and-virus-neutralizing-igm-antibodies
#6
Surender Khurana, Sandra Fuentes, Elizabeth M Coyle, Supriya Ravichandran, Richard T Davey, John H Beigel
No abstract text is available yet for this article.
February 7, 2017: Nature Medicine
https://www.readbyqxmd.com/read/28167539/chemically-modified-human-serum-albumin-potently-blocks-entry-of-ebola-pseudoviruses-and-virus-like-particles
#7
Haoyang Li, Fei Yu, Shuai Xia, Yufeng Yu, Qian Wang, Ming Lv, Yan Wang, Shibo Jiang, Lu Lu
Ebola virus (EBOV), causative pathogen of the deadly Ebola virus disease (EVD), can be transmitted via contact with EVD patients, including sexual contact with EVD survivors. At present, no licensed vaccine or therapeutic is available. In this study, we compared eight anhydride-modified proteins for their inhibitory activity against entry of the pseudovirus (PsV) carrying the envelope glycoprotein (GP) of EBOV Zaire or Sudan species. We found that 3-hydroxyphthalic anhydride-modified human serum albumin (HP-HSA) was most effective in inhibiting entry of both Zaire-PsV and Sudan-PsV, with EC50 at nanomolar level, more potent than EBOV-neutralizing antibody, MIL77-2 (4G7)...
February 6, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28161420/comparison-of-platform-technologies-for-assaying-antibody-to-ebola-virus
#8
Dianna E Wilkinson, Mark Page, Giada Mattiuzzo, Mark Hassall, Thomas Dougall, Peter Rigsby, Lindsay Stone, Philip Minor
BACKGROUND: The recent Ebola outbreak in West Africa led to the use of a variety of different platform technologies for assaying antibodies because of the difficulties of handling the live virus. The same types of method could be applied rapidly to other infections when they emerge. There is a need to compare quantitative results of different assays, which means that the assays must measure similar parameters and give comparable results. METHODS: A collaborative study was carried out to establish an International Reference Reagent through WHO...
February 1, 2017: Vaccine
https://www.readbyqxmd.com/read/28159028/the-health-impact-of-the-2014-15-ebola-outbreak
#9
REVIEW
J W T Elston, C Cartwright, P Ndumbi, J Wright
OBJECTIVES: The 2014-15 outbreak in West Africa was the largest and deadliest Ebola outbreak recorded; however, there remains uncertainty over its wider health consequences. Our objective was to provide a comprehensive overview of the impact of the Ebola outbreak on population health in the three most affected countries: Sierra Leone, Liberia and Guinea. STUDY DESIGN: Narrative review. METHODS: A narrative overview of the peer-reviewed and grey literature related to the impact and consequences of the Ebola outbreak was conducted, synthesizing the findings of literature retrieved from a structured search of biomedical databases, the Web and references of reviewed articles...
February 2017: Public Health
https://www.readbyqxmd.com/read/28152326/safety-and-immunogenicity-of-gamevac-combi-a-heterologous-vsv-and-ad5-vectored-ebola-vaccine-an-open-phase-i-ii-trial-in-healthy-adults-in-russia
#10
I V Dolzhikova, O V Zubkova, A I Tukhvatulin, A S Dzharullaeva, N M Tukhvatulina, D V Shcheblyakov, M M Shmarov, E A Tokarskaya, Y V Simakova, D A Egorova, D N Scherbinin, I L Tutykhina, A A Lysenko, A V Kostarnoy, P G Gancheva, T A Ozharovskaya, B V Belugin, L V Kolobukhina, V B Pantyukhov, S I Syromyatnikova, I V Shatokhina, T V Sizikova, I G Rumyantseva, A F Andrus, N V Boyarskaya, A N Voytyuk, V F Babira, S V Volchikhina, D A Kutaev, A N Bel'skih, K V Zhdanov, S M Zakharenko, S V Borisevich, D Y Logunov, B S Naroditsky, A L Gintsburg
Ebola hemorrhagic fever, also known as Ebola virus disease or EVD, is one of the most dangerous viral diseases in humans and animals. In this open-label, dose-escalation clinical trial, we assessed the safety, side effects, and immunogenicity of a novel, heterologous prime-boost vaccine against Ebola, which was administered in 2 doses to 84 healthy adults of both sexes between 18 and 55 years. The vaccine consists of live-attenuated recombinant vesicular stomatitis virus (VSV) and adenovirus serotype-5 (Ad5) expressing Ebola envelope glycoprotein...
February 2, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28148944/ebola-vaccine-success
#11
Asher Mullard
No abstract text is available yet for this article.
February 2, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28146366/cdc-s-evolving-approach-to-emergency-response
#12
Stephen C Redd, Thomas R Frieden
The Centers for Disease Control and Prevention (CDC) transformed its approach to preparing for and responding to public health emergencies following the anthrax attacks of 2001. The Office of Public Health Preparedness and Response, an organizational home for emergency response at CDC, was established, and 4 programs were created or greatly expanded after the anthrax attacks: (1) an emergency management program, including an Emergency Operations Center; (2) increased support of state and local health department efforts to prepare for emergencies; (3) a greatly enlarged Strategic National Stockpile of medicines, vaccines, and medical equipment; and (4) a regulatory program to assure that work done on the most dangerous pathogens and toxins is done as safely and securely as possible...
January 2017: Health Security
https://www.readbyqxmd.com/read/28109709/the-effect-of-gamma-irradiation-conditions-on-the-immunogenicity-of-whole-inactivated-influenza-a-virus-vaccine
#13
Shannon C David, Josyane Lau, Eve V Singleton, Rachelle Babb, Justin Davies, Timothy R Hirst, Shaun R McColl, James C Paton, Mohammed Alsharifi
Gamma-irradiation, particularly an irradiation dose of 50kGy, has been utilised widely to sterilise highly pathogenic agents such as Ebola, Marburg Virus, and Avian Influenza H5N1. We have reported previously that intranasal vaccination with a gamma-irradiated Influenza A virus vaccine (γ-Flu) results in cross-protective immunity. Considering the possible inclusion of highly pathogenic Influenza strains in future clinical development of γ-Flu, an irradiation dose of 50kGy may be used to enhance vaccine safety beyond the internationally accepted Sterility Assurance Level (SAL)...
January 18, 2017: Vaccine
https://www.readbyqxmd.com/read/28107867/an-update-on-the-2014-ebola-outbreak-in-western-africa
#14
REVIEW
Haaris A Shiwani, Rebabonye B Pharithi, Barkat Khan, Christian Binoun-A Egom, Peter Kruzliak, Vincent Maher, Emmanuel Eroume-A Egom
The recent Ebola outbreak in Western Africa was the most devastating outbreak witnessed in recent times. There have been remarkable local and international efforts to control the crisis. Ebola Virus Disease is the focus of immense research activity. The progression of events in the region has been evolving swiftly and it is of paramount importance to the medical community to be acquainted with the situation. Over 28000 people were inflicted with the condition, over 11000 have died. Novel data has emerged regarding modes of transmission, providing rationale for recent flare-ups...
January 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28091625/mplex-a-method-for-simultaneous-pathogen-inactivation-and-extraction-of-samples-for-multi-omics-profiling
#15
Kristin E Burnum-Johnson, Jennifer E Kyle, Amie J Eisfeld, Cameron P Casey, Kelly G Stratton, Juan F Gonzalez, Fabien Habyarimana, Nicholas M Negretti, Amy C Sims, Sadhana Chauhan, Larissa B Thackray, Peter J Halfmann, Kevin B Walters, Young-Mo Kim, Erika M Zink, Carrie D Nicora, Karl K Weitz, Bobbie-Jo M Webb-Robertson, Ernesto S Nakayasu, Brian Ahmer, Michael E Konkel, Vladimir Motin, Ralph S Baric, Michael S Diamond, Yoshihiro Kawaoka, Katrina M Waters, Richard D Smith, Thomas O Metz
The continued emergence and spread of infectious agents is of great concern, and systems biology approaches to infectious disease research can advance our understanding of host-pathogen relationships and facilitate the development of new therapies and vaccines. Molecular characterization of infectious samples outside of appropriate biosafety containment can take place only subsequent to pathogen inactivation. Herein, we describe a modified Folch extraction using chloroform/methanol that facilitates the molecular characterization of infectious samples by enabling simultaneous pathogen inactivation and extraction of proteins, metabolites, and lipids for subsequent mass spectrometry-based multi-omics measurements...
January 26, 2017: Analyst
https://www.readbyqxmd.com/read/28081225/fighting-ebola-a-window-for-vaccine-re-evaluation
#16
Keith J Chappell, Daniel Watterson
No abstract text is available yet for this article.
January 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28075069/ebola-vaccination-using-a-dna-vaccine-coated-on-plga-pll-%C3%AE-pga-nanoparticles-administered-using-a-microneedle-patch
#17
Hung-Wei Yang, Ling Ye, Xin Dong Guo, Chinglai Yang, Richard W Compans, Mark R Prausnitz
Ebola DNA vaccine is incorporated into PLGA-PLL/γPGA nanoparticles and administered to skin using a microneedle (MN) patch. The nanoparticle delivery system increases vaccine thermostability and immunogenicity compared to free vaccine. Vaccination by MN patch produces stronger immune responses than intramuscular administration.
January 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28057259/modified-vaccinia-virus-ankara-history-value-in-basic-research-and-current-perspectives-for-vaccine-development
#18
REVIEW
A Volz, G Sutter
Safety tested Modified Vaccinia virus Ankara (MVA) is licensed as third-generation vaccine against smallpox and serves as a potent vector system for development of new candidate vaccines against infectious diseases and cancer. Historically, MVA was developed by serial tissue culture passage in primary chicken cells of vaccinia virus strain Ankara, and clinically used to avoid the undesirable side effects of conventional smallpox vaccination. Adapted to growth in avian cells MVA lost the ability to replicate in mammalian hosts and lacks many of the genes orthopoxviruses use to conquer their host (cell) environment...
2017: Advances in Virus Research
https://www.readbyqxmd.com/read/28042619/beating-the-odds-successful-establishment-of-a-phase-ii-iii-clinical-research-trial-in-resource-poor-liberia-during-the-largest-ever-ebola-outbreak
#19
J Doe-Anderson, B Baseler, P Driscoll, M Johnson, J Lysander, L McNay, W S Njoh, M Smolskis, L Wehrlen, J Zuckerman
It has been argued that a country such as Liberia, not fully recovered from the devastation of decades of civil unrest, lacked the appropriate ethical and regulatory framework, basic human and health care services, and infrastructure to carry out clinical trials according to international standards of quality during a public health emergency. However, as Liberia, Sierra Leone, and Guinea were being ravaged by the largest and most devastating Ebola Virus Disease (EVD) outbreak ever recorded, the topic of conducting clinical trials of experimental vaccine and treatment candidates in these resource-poor countries generated the keen interest and concern of scientists, researchers, physicians, bioethicists, philanthropists, and even politicians...
December 15, 2016: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/28040206/interest-in-an-ebola-vaccine-among-a-u-s-national-sample-during-the-height-of-the-2014-2016-ebola-outbreak-in-west-africa
#20
Julia E Painter, Ralph J DiClemente, Michael E von Fricken
To better understand the association between Ebola-related attitudes and interest in receiving an Ebola virus vaccine, a survey was administered to a U.S. national sample using GfK's KnowledgePanel®. Among participants (N=1417), 34.1% expressed interest in an Ebola vaccine for themselves. In the subset of participants with children aged 0-17 (N=410), 38.1% expressed interest in an Ebola vaccine for their child. In multivariable analyses, vaccine interest for oneself was associated with perceived susceptibility to Ebola (p=0...
December 28, 2016: Vaccine
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