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Marburg virus

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https://www.readbyqxmd.com/read/29774854/marburg-virus-infection-in-egyptian-rousette-bats-south-africa-2013-2014-1
#1
Janusz T Pawęska, Petrus Jansen van Vuren, Alan Kemp, Nadia Storm, Antoinette A Grobbelaar, Michael R Wiley, Gustavo Palacios, Wanda Markotter
We detected a high seroprevalence of Marburg virus (MARV) antibodies in fruit bats in South Africa; 19.1% of recaptured bats seroconverted. The MARV RNA isolated closely resembled the 1975 Ozolin strain. These findings indicate endemic MARV circulation in bats in South Africa and should inform policies on MARV disease risk reduction.
June 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29725132/post-exposure-treatments-for-ebola-and-marburg-virus-infections
#2
Robert W Cross, Chad E Mire, Heinz Feldmann, Thomas W Geisbert
This corrects the article DOI: 10.1038/nrd.2017.251.
May 4, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/29719780/establishment-of-pseudovirus-infection-mouse-models-for-in-vivo-pharmacodynamics-evaluation-of-filovirus-entry-inhibitors
#3
Qing Chen, Ke Tang, Xiaoyu Zhang, Panpan Chen, Ying Guo
Filoviruses cause severe and fatal viral hemorrhagic fever in humans. Filovirus research has been extensive since the 2014 Ebola outbreak. Due to their high pathogenicity and mortality, live filoviruses require Biosafety Level-4 (BSL-4) facilities, which have restricted the development of anti-filovirus vaccines and drugs. An HIV-based pseudovirus cell infection assay is widely used for viral entry studies in BSL-2 conditions. Here, we successfully constructed nine in vitro pseudo-filovirus models covering all filovirus genera and three in vivo pseudo-filovirus-infection mouse models using Ebola virus, Marburg virus, and Lloviu virus as representative viruses...
March 2018: Acta Pharmaceutica Sinica. B
https://www.readbyqxmd.com/read/29706541/the-egyptian-rousette-genome-reveals-unexpected-features-of-bat-antiviral-immunity
#4
Stephanie S Pavlovich, Sean P Lovett, Galina Koroleva, Jonathan C Guito, Catherine E Arnold, Elyse R Nagle, Kirsten Kulcsar, Albert Lee, Françoise Thibaud-Nissen, Adam J Hume, Elke Mühlberger, Luke S Uebelhoer, Jonathan S Towner, Raul Rabadan, Mariano Sanchez-Lockhart, Thomas B Kepler, Gustavo Palacios
Bats harbor many viruses asymptomatically, including several notorious for causing extreme virulence in humans. To identify differences between antiviral mechanisms in humans and bats, we sequenced, assembled, and analyzed the genome of Rousettus aegyptiacus, a natural reservoir of Marburg virus and the only known reservoir for any filovirus. We found an expanded and diversified KLRC/KLRD family of natural killer cell receptors, MHC class I genes, and type I interferons, which dramatically differ from their functional counterparts in other mammals...
April 18, 2018: Cell
https://www.readbyqxmd.com/read/29698959/lectin-affinity-plasmapheresis-for-middle-east-respiratory-syndrome-coronavirus-and-marburg-virus-glycoprotein-elimination
#5
Benjamin Koch, Patricia Schult-Dietrich, Stefan Büttner, Bijan Dilmaghani, Dario Lohmann, Patrick C Baer, Ursula Dietrich, Helmut Geiger
BACKGROUND/AIMS: Middle East respiratory syndrome coronavirus (MERS-CoV) and Marburg virus (MARV) are among the World Health Organization's top 8 emerging pathogens. Both zoonoses share nonspecific early symptoms, a high lethality rate, and a reduced number of specific treatment options. Therefore, we evaluated extracorporeal virus and glycoprotein (GP) elimination by lectin affinity plasmapheresis (LAP). METHODS: For both MERS-CoV (pseudovirus) as well as MARV (GPs), 4 LAP devices (Mini Hemopurifiers, Aethlon Medical, San Diego, CA, USA) and 4 negative controls were tested...
April 26, 2018: Blood Purification
https://www.readbyqxmd.com/read/29685158/ebolavirus-diagnosis-made-simple-comparable-and-faster-than-molecular-detection-methods-preparing-for-the-future
#6
Ameh S James, Shawn Todd, Nina M Pollak, Glenn A Marsh, Joanne Macdonald
BACKGROUND: The 2014/2015 Ebolavirus outbreak resulted in more than 28,000 cases and 11,323 reported deaths, as of March 2016. Domestic transmission of the Guinea strain associated with the outbreak occurred mainly in six African countries, and international transmission was reported in four countries. Outbreak management was limited by the inability to rapidly diagnose infected cases. A further fifteen countries in Africa are predicted to be at risk of Ebolavirus outbreaks in the future as a consequence of climate change and urbanization...
April 23, 2018: Virology Journal
https://www.readbyqxmd.com/read/29584652/identification-of-ellagic-acid-from-plant-rhodiola-rosea-l-as-an-anti-ebola-virus-entry-inhibitor
#7
Qinghua Cui, Ruikun Du, Manu Anantpadma, Adam Schafer, Lin Hou, Jingzhen Tian, Robert A Davey, Han Cheng, Lijun Rong
The recent 2014-2016 West African Ebola virus epidemic underscores the need for the development of novel anti-Ebola therapeutics, due to the high mortality rates of Ebola virus infections and the lack of FDA-approved vaccine or therapy that is available for the prevention and treatment. Traditional Chinese medicines (TCMs) represent a huge reservoir of bioactive chemicals and many TCMs have been shown to have antiviral activities. 373 extracts from 128 TCMs were evaluated using a high throughput assay to screen for inhibitors of Ebola virus cell entry...
March 27, 2018: Viruses
https://www.readbyqxmd.com/read/29554213/scotch-subtype-a-coreceptor-tropism-classification-in-hiv-1
#8
Hannah F Löchel, Mona Riemenschneider, Dmitrij Frishman, Dominik Heider
Motivation: The V3 loop of the gp120 glycoprotein of the Human Immunodeficiency Virus 1 (HIV-1) is considered to be responsible for viral coreceptor tropism. gp120 interacts with the CD4 receptor of the host cell and subsequently V3 binds either CCR5 or CXCR4. Due to the fact that the CCR5 coreceptor is targeted by entry inhibitors, a reliable prediction of the coreceptor usage of HIV-1 is of great interest for antiretroviral therapy. Although several methods for the prediction of coreceptor tropism are available, almost all of them have been developed based on only subtype B sequences, and it has been shown in several studies that the prediction of non-B sequences, in particular subtype A sequences, are less reliable...
March 15, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29551136/filoviruses-ecology-molecular-biology-and-evolution
#9
Jackson Emanuel, Andrea Marzi, Heinz Feldmann
The Filoviridae are a family of negative-strand RNA viruses that include several important human pathogens. Ebola virus (EBOV) and Marburg virus are well-known filoviruses which cause life-threatening viral hemorrhagic fever in human and nonhuman primates. In addition to severe pathogenesis, filoviruses also exhibit a propensity for human-to-human transmission by close contact, posing challenges to containment and crisis management. Past outbreaks, in particular the recent West African EBOV epidemic, have been responsible for thousands of deaths and vaulted the filoviruses into public consciousness...
2018: Advances in Virus Research
https://www.readbyqxmd.com/read/29511143/development-and-characterization-of-a-guinea-pig-model-for-marburg-virus
#10
Gary Wong, Wen-Guang Cao, Shi-Hua He, Zi-Rui Zhang, Wen-Jun Zhu, Estella Moffat, Hideki Ebihara, Carissa Embury-Hyatt, Xiang-Guo Qiu
The Angolan strain of Marburg virus (MARV/Ang) can cause lethal disease in humans with a case fatality rate of up to 90%, but infection of immunocompetent rodents do not result in any observable symptoms. Our previous work includes the development and characterization of a MARV/Ang variant that can cause lethal disease in mice (MARV/Ang-MA), with the aim of using this tool to screen for promising prophylactic and therapeutic candidates. An intermediate animal model is needed to confirm any findings from mice studies before testing in the gold-standard non-human primate (NHP) model...
January 18, 2018: Zoological Research
https://www.readbyqxmd.com/read/29500195/design-and-evaluation-of-bi-and-trispecific-antibodies-targeting-multiple-filovirus-glycoproteins
#11
Elisabeth K Nyakatura, Samantha E Zak, Anna Z Wec, Daniel Hofmann, Sergey Shulenin, Russell R Bakken, M Javad Aman, Kartik Chandran, John M Dye, Jonathan R Lai
Filoviruses (family Filoviridae) include five ebolaviruses and Marburg virus. These pathogens cause a rapidly progressing and severe viral disease with high mortality rates (generally 30-90%). Outbreaks of filovirus disease are sporadic and, until recently, were limited to less than 500 cases. However, the 2013-2016 epidemic in western Africa, caused by Ebola virus (EBOV), illustrated the potential of filovirus outbreaks to escalate to a much larger scale (over 28,000 suspected cases). mAbs against the envelope glycoprotein represent a promising therapeutic platform for managing filovirus infections...
April 20, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29494844/discovery-and-evolution-of-aloperine-derivatives-as-novel-anti-filovirus-agents-through-targeting-entry-stage
#12
Xin Zhang, Qiang Liu, Na Zhang, Qian-Qian Li, Zhan-Dong Liu, Ying-Hong Li, Li-Mei Gao, You-Chun Wang, Hong-Bin Deng, Dan-Qing Song
Preventing filoviruses in the entry stage is an attractive antiviral strategy. Taking aloperine, a Chinese natural herb with an endocyclic skeleton, as the lead, 23 new aloperine derivatives were synthesized and evaluated for their anti-filovirus activities including ebola virus (EBOV) and marburg virus (MARV) using pseudotyped virus model. Structure-activity relationship (SAR) analysis indicated that the introduction of a 12N-dichlorobenzyl group was beneficial for the potency. Compound 2e exhibited the most potent anti-EBOV and anti-MARV effects both in vitro and in vivo...
April 10, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29462200/a-prophylactic-multivalent-vaccine-against-different-filovirus-species-is-immunogenic-and-provides-protection-from-lethal-infections-with-ebolavirus-and-marburgvirus-species-in-non-human-primates
#13
Benoit Callendret, Jort Vellinga, Kerstin Wunderlich, Ariane Rodriguez, Robin Steigerwald, Ulrike Dirmeier, Cedric Cheminay, Ariane Volkmann, Trevor Brasel, Ricardo Carrion, Luis D Giavedoni, Jean L Patterson, Chad E Mire, Thomas W Geisbert, Jay W Hooper, Mo Weijtens, Jutta Hartkoorn-Pasma, Jerome Custers, Maria Grazia Pau, Hanneke Schuitemaker, Roland Zahn
The search for a universal filovirus vaccine that provides protection against multiple filovirus species has been prompted by sporadic but highly lethal outbreaks of Ebolavirus and Marburgvirus infections. A good prophylactic vaccine should be able to provide protection to all known filovirus species and as an upside potentially protect from newly emerging virus strains. We investigated the immunogenicity and protection elicited by multivalent vaccines expressing glycoproteins (GP) from Ebola virus (EBOV), Sudan virus (SUDV), Taï Forest virus (TAFV) and Marburg virus (MARV)...
2018: PloS One
https://www.readbyqxmd.com/read/29457711/small-animal-models-for-evaluating-filovirus-countermeasures
#14
Logan Banadyga, Gary Wong, Xiangguo Qiu
The development of novel therapeutics and vaccines to treat or prevent disease caused by filoviruses, such as Ebola and Marburg viruses, depends on the availability of animal models that faithfully recapitulate clinical hallmarks of disease as it is observed in humans. In particular, small animal models (such as mice and guinea pigs) are historically and frequently used for the primary evaluation of antiviral countermeasures, prior to testing in nonhuman primates, which represent the gold-standard filovirus animal model...
February 26, 2018: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29454637/tools-to-study-pathogen-host-interactions-in-bats
#15
REVIEW
Arinjay Banerjee, Vikram Misra, Tony Schountz, Michelle L Baker
Bats are natural reservoirs for a variety of emerging viruses that cause significant disease in humans and domestic animals yet rarely cause clinical disease in bats. The co-evolutionary history of bats with viruses has been hypothesized to have shaped the bat-virus relationship, allowing both to exist in equilibrium. Progress in understanding bat-virus interactions and the isolation of bat-borne viruses has been accelerated in recent years by the development of susceptible bat cell lines. Viral sequences similar to severe acute respiratory syndrome corona virus (SARS-CoV) have been detected in bats, and filoviruses such as Marburg virus have been isolated from bats, providing definitive evidence for the role of bats as the natural host reservoir...
March 15, 2018: Virus Research
https://www.readbyqxmd.com/read/29439384/antibody-responses-to-marburg-virus-in-egyptian-rousette-bats-and-their-role-in-protection-against-infection
#16
Nadia Storm, Petrus Jansen Van Vuren, Wanda Markotter, Janusz T Paweska
Egyptian rousette bats (ERBs) are reservoir hosts for the Marburg virus (MARV). The immune dynamics and responses to MARV infection in ERBs are poorly understood, and limited information exists on the role of antibodies in protection of ERBs against MARV infection. Here, we determine the duration of maternal immunity to MARV in juvenile ERBs, and evaluate the duration of the antibody response to MARV in bats naturally or experimentally infected with the virus. We further explore whether antibodies in previously naturally exposed bats is fully protective against experimental reinfection with MARV...
February 10, 2018: Viruses
https://www.readbyqxmd.com/read/29375139/post-exposure-treatments-for-ebola-and-marburg-virus-infections
#17
REVIEW
Robert W Cross, Chad E Mire, Heinz Feldmann, Thomas W Geisbert
The filoviruses - Ebola virus and Marburg virus - cause lethal haemorrhagic fever in humans and non-human primates (NHPs). Filoviruses present a global health threat both as naturally acquired diseases and as potential agents of bioterrorism. In the recent 2013-2016 outbreak of Ebola virus, the most promising therapies for post-exposure use with demonstrated efficacy in the gold-standard NHP models of filovirus disease were unable to show statistically significant protection in patients infected with Ebola virus...
January 29, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/29369776/successful-treatment-of-marburg-virus-with-orally-administrated-t-705-favipiravir-in-a-mouse-model
#18
Wenjun Zhu, Zirui Zhang, Shihua He, Gary Wong, Logan Banadyga, Xiangguo Qiu
Filoviruses, such as Marburg and Ebola viruses, cause severe disease in humans with high case fatality rates and are therefore considered biological threat agents. To date, no licensed vaccine or therapeutic exists for their treatment. T-705 (favipiravir) is a pyrazinecarboxamide derivative that has shown broad antiviral activity against a number of viruses and is clinically licenced in Japan to treat influenza. Here we report the efficacy of T-705 against Marburg virus infection in vitro and in vivo. Notably, oral administration of T-705 beginning one or two days post-infection and continuing for eight days resulted in complete survival of mice that had been intraperitoneally infected with mouse-adapted Marburg virus (variant Angola)...
March 2018: Antiviral Research
https://www.readbyqxmd.com/read/29305306/filovirus-proteins-for-antiviral-drug-discovery-structure-function-of-proteins-involved-in-assembly-and-budding
#19
REVIEW
Baptiste Martin, Olivier Reynard, Viktor Volchkov, Etienne Decroly
There are no approved medications for the treatment of Marburg or Ebola virus infection. In two previous articles (Martin et al., 2016, Martin et al., 2017), we reviewed surface glycoprotein and replication proteins structure/function relationship to decipher the molecular mechanisms of filovirus life cycle and identify antiviral strategies. In the present article, we recapitulate knowledge about the viral proteins involved in filovirus assembly and budding. First we describe the structural data available for viral proteins associated with virus assembly and virion egress and then, we integrate the structural features of these proteins in the functional context of the viral replication cycle...
February 2018: Antiviral Research
https://www.readbyqxmd.com/read/29299527/a-single-amino-acid-change-in-the-marburg-virus-glycoprotein-arises-during-serial-cell-culture-passages-and-attenuates-the-virus-in-a-macaque-model-of-disease
#20
Kendra J Alfson, Laura E Avena, Jenny Delgado, Michael W Beadles, Jean L Patterson, Ricardo Carrion, Anthony Griffiths
Marburg virus (MARV) causes disease with high case fatality rates, and there are no approved vaccines or therapies. Licensing of MARV countermeasures will likely require approval via the FDA's Animal Efficacy Rule, which requires well-characterized animal models that recapitulate human disease. This includes selection of the virus used for exposure and ensuring that it retains the properties of the original isolate. The consequences of amplification of MARV for challenge studies are unknown. Here, we serially passaged and characterized MARV through 13 passes from the original isolate...
January 2018: MSphere
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