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Hemorrhagic Fever viruses

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https://www.readbyqxmd.com/read/28640917/human-hantavirus-infection-elicits-pronounced-redistribution-of-mononuclear-phagocytes-in-peripheral-blood-and-airways
#1
Saskia Scholz, Faezzah Baharom, Gregory Rankin, Kimia T Maleki, Shawon Gupta, Sindhu Vangeti, Jamshid Pourazar, Andrea Discacciati, Jonas Höijer, Matteo Bottai, Niklas K Björkström, Johan Rasmuson, Magnus Evander, Anders Blomberg, Hans-Gustaf Ljunggren, Jonas Klingström, Clas Ahlm, Anna Smed-Sörensen
Hantaviruses infect humans via inhalation of virus-contaminated rodent excreta. Infection can cause severe disease with up to 40% mortality depending on the viral strain. The virus primarily targets the vascular endothelium without direct cytopathic effects. Instead, exaggerated immune responses may inadvertently contribute to disease development. Mononuclear phagocytes (MNPs), including monocytes and dendritic cells (DCs), orchestrate the adaptive immune responses. Since hantaviruses are transmitted via inhalation, studying immunological events in the airways is of importance to understand the processes leading to immunopathogenesis...
June 22, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28636653/the-ebola-virus-vp35-protein-binds-viral-immunostimulatory-and-host-rnas-identified-through-deep-sequencing
#2
Kari A Dilley, Alexander A Voorhies, Priya Luthra, Vinita Puri, Timothy B Stockwell, Hernan Lorenzi, Christopher F Basler, Reed S Shabman
Ebola virus and Marburg virus are members of the Filovirdae family and causative agents of hemorrhagic fever with high fatality rates in humans. Filovirus virulence is partially attributed to the VP35 protein, a well-characterized inhibitor of the RIG-I-like receptor pathway that triggers the antiviral interferon (IFN) response. Prior work demonstrates the ability of VP35 to block potent RIG-I activators, such as Sendai virus (SeV), and this IFN-antagonist activity is directly correlated with its ability to bind RNA...
2017: PloS One
https://www.readbyqxmd.com/read/28630325/convergent-immunological-solutions-to-argentine-hemorrhagic-fever-virus-neutralization
#3
Antra Zeltina, Stefanie A Krumm, Mehmet Sahin, Weston B Struwe, Karl Harlos, Jack H Nunberg, Max Crispin, Daniel D Pinschewer, Katie J Doores, Thomas A Bowden
Transmission of hemorrhagic fever New World arenaviruses from their rodent reservoirs to human populations poses substantial public health and economic dangers. These zoonotic events are enabled by the specific interaction between the New World arenaviral attachment glycoprotein, GP1, and cell surface human transferrin receptor (hTfR1). Here, we present the structural basis for how a mouse-derived neutralizing antibody (nAb), OD01, disrupts this interaction by targeting the receptor-binding surface of the GP1 glycoprotein from Junín virus (JUNV), a hemorrhagic fever arenavirus endemic in central Argentina...
June 19, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28622346/flavivirus-and-filovirus-evoprinters-new-alignment-tools-for-the-comparative-analysis-of-viral-evolution
#4
Thomas Brody, Amarendra S Yavatkar, Dong Sun Park, Alexander Kuzin, Jermaine Ross, Ward F Odenwald
BACKGROUND: Flavivirus and Filovirus infections are serious epidemic threats to human populations. Multi-genome comparative analysis of these evolving pathogens affords a view of their essential, conserved sequence elements as well as progressive evolutionary changes. While phylogenetic analysis has yielded important insights, the growing number of available genomic sequences makes comparisons between hundreds of viral strains challenging. We report here a new approach for the comparative analysis of these hemorrhagic fever viruses that can superimpose an unlimited number of one-on-one alignments to identify important features within genomes of interest...
June 16, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28613285/dengue-hemorrhagic-fever-in-the-northwest-of-mexico-a-two-decade-analysis
#5
Vania Serrano-Pinto, Manuel Moreno-Legorretara
BACKGROUND: In Baja California Sur, Mexico, there are no records of dengue hemorrhagic fever in the state before 1995. Until now, there have been no published reports on the incidence rate. OBJECTIVE: To assess the incidence rate of dengue hemorrhagic fever in Baja California Sur in the last two decades. METHODS: We analyzed data on the total number of cases in the general population, incidence rate, age groups, gender, serotypes, and mortality data...
May 2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/28612239/dengue-hemorrhagic-fever-a-state-of-the-art-review-focused-in-pulmonary-involvement
#6
REVIEW
Renata Rocha de Almeida, Bernardo Paim, Solange Artimos de Oliveira, Arthur Soares Souza, Antônio Carlos Portugal Gomes, Dante Luiz Escuissato, Gláucia Zanetti, Edson Marchiori
Dengue fever is an arboviral disease transmitted to humans through the bites of infected female Aedes mosquitoes. Dengue virus is a member of the Flaviviridae family, and human infection can be caused by any of the four antigenically distinct serotypes (DENV 1-4). The infection has become recognized as the most important and prevalent arboviral disease in humans, endemic in almost 100 countries worldwide. Nearly 3 billion people live in areas with transmission risk. Autochthonous transmission of the virus in previously disease-free areas, increased incidence in endemic areas, and epidemic resurgence in controlled regions could increase the risk of contracting more severe forms of the disease, such as dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS)...
June 13, 2017: Lung
https://www.readbyqxmd.com/read/28611428/deep-sequencing-of-marburg-virus-genome-during-sequential-mouse-passaging-and-cell-culture-adaptation-reveals-extensive-changes-over-time
#7
Haiyan Wei, Jonathan Audet, Gary Wong, Shihua He, Xueyong Huang, Todd Cutts, Steven Theriault, Bianli Xu, Gary Kobinger, Xiangguo Qiu
Marburg virus (MARV) has caused outbreaks of filoviral hemorrhagic fever since its discovery in 1967. The largest and deadliest outbreak occurred in Angola in 2005, with 252 cases and 227 deaths. In 2014, we developed a mouse-adapted MARV, Angola variant through serial passaging in mice. The mouse-adapted MARV exhibits many of the hallmarks of MARV disease in humans. By applying deep-sequencing to every passage of the virus, we are able to study virus evolution in this host with surprising precision. We show that two regions go through substantial changes: the intergenic region between NP and VP35, as well as the first 100 amino acids of the VP40 protein...
June 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28605299/crimean-congo-hemorrhagic-fever-virus-specific-antibody-detection-in-cattle-in-mauritania
#8
Miriam A Sas, Marc Mertens, Ekaterina Isselmou, Nicole Reimer, Bezeid O El Mamy, Baba Doumbia, Martin H Groschup
BACKGROUND: Crimean-Congo hemorrhagic fever virus (CCHFV) was detected for the first time in Mauritania in 1983 and several CCHFV outbreaks were reported in the following years. The last human case was diagnosed in 2015. However, no recent data exist about the prevalence of CCHFV in animals, although it is already described that prevalence studies in animals serve as good risk indicators. CCHFV can cause a severe hemorrhagic fever with a high case fatality rate in humans. Therefore, a precise risk assessment on the basis of updated data is very important...
June 12, 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28603698/crimean-congo-hemorrhagic-fever-tick-host-virus-interactions
#9
REVIEW
Anna Papa, Katerina Tsergouli, Katerina Tsioka, Ali Mirazimi
Crimean-Congo hemorrhagic fever virus (CCHFV) is transmitted to humans by bite of infected ticks or by direct contact with blood or tissues of viremic patients or animals. It causes to humans a severe disease with fatality up to 30%. The current knowledge about the vector-host-CCHFV interactions is very limited due to the high-level containment required for CCHFV studies. Among ticks, Hyalomma spp. are considered the most competent virus vectors. CCHFV evades the tick immune response, and following its replication in the lining of the tick's midgut, it is disseminated by the hemolymph in the salivary glands and reproductive organs...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28603449/filoviruses-and-bats
#10
Amy J Schuh, Brian R Amman, Jonathan S Towner
While Reston and Lloviu viruses have never been associated with human disease, the other filoviruses cause outbreaks of hemorrhagic fever characterised by person-to-person transmission and high case fatality ratios. Cumulative evidence suggests that bats are the most likely reservoir hosts of the filoviruses. Ecological investigations following Marburg virus disease outbreaks associated with entry into caves inhabited by Rousettus aegyptiacus bats led to the identification of this bat species as the natural reservoir host of the marburgviruses...
March 2017: Microbiology Australia
https://www.readbyqxmd.com/read/28596387/draft-genome-sequences-of-eight-crimean-congo-hemorrhagic-fever-virus-strains
#11
J W Koehler, K L Delp, B J Kearney, T A Conrad, R J Schoepp, A R Garrison, L A Altamura, C A Rossi, T D Minogue
Crimean-Congo hemorrhagic fever virus (CCHFV) is a geographically widespread RNA virus with a high degree of genomic diversity that complicates sequence-based diagnostics. Here, we sequenced eight CCHFV strains for improved assay design and deposition into FDA-ARGOS, the FDA's pathogen database for development and verification of next generation sequencing assays.
June 8, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28591408/decrease-in-dengue-virus-2-infection-and-reduction-of-cytokine-chemokine-production-by-uncaria-guianensis-in-human-hepatocyte-cell-line-huh-7
#12
Cíntia da Silva Mello, Ligia Maria Marino Valente, Thiago Wolff, Raimundo Sousa Lima-Junior, Luciana Gomes Fialho, Cintia Ferreira Marinho, Elzinandes Leal Azeredo, Luzia Maria Oliveira-Pinto, Rita de Cássia Alves Pereira, Antonio Carlos Siani, Claire Fernandes Kubelka
BACKGROUND: Dengue fever may present hemorrhages and cavitary effusions as result of exacerbated immune responses. We investigated hydro-alcoholic extracts from leaves (UGL) and bark (UGB) of the medicinal species Uncaria guinanensis with respect to antiviral effects in Dengue virus (DENV) infection and in immunological parameters associated with in vivo physiopathological features. METHODS: Chemical profiles from UGB or UGL were compared in thin layer chromatography and 1H nuclear magnetic resonance using flavonoid compounds and a pentacyclic oxindole alkaloid-enriched fraction as references...
June 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28580138/plasma-membrane-association-facilitates-conformational-changes-in-the-marburg-virus-protein-vp40-dimer
#13
Nisha Bhattarai, Jeevan B Gc, Bernard S Gerstman, Robert V Stahelin, Prem P Chapagain
Filovirus infections cause hemorrhagic fever in humans and non-human primates that often results in high fatality rates. The Marburg virus is a lipid-enveloped virus from the Filoviridae family and is closely related to the Ebola virus. The viral matrix layer underneath the lipid envelope is formed by the matrix protein VP40 (VP40), which is also involved in other functions during the viral life-cycle. As in the Ebola virus VP40 (eVP40), the recently determined X-ray crystal structure of the Marburg virus VP40 (mVP40) features loops containing cationic residues that form a lipid binding basic patch...
April 26, 2017: RSC Advances
https://www.readbyqxmd.com/read/28579441/the-role-of-ticks-in-the-maintenance-and-transmission-of-crimean-congo-hemorrhagic-fever-virus-a-review-of-published-field-and-laboratory-studies
#14
REVIEW
Aysen Gargili, Agustin Estrada-Peña, Jessica R Spengler, Alexander Lukashev, Patricia A Nuttall, Dennis A Bente
This manuscript is part of a series of reviews that aim to cover published research on Crimean-Congo hemorrhagic fever (CCHF) and its etiological agent, CCHF virus (CCHFV). The virus is maintained and transmitted in a vertical and horizontal transmission cycle involving a variety of wild and domestic vertebrate species that act as amplification hosts, without showing signs of illness. These vertebrates have traditionally been considered reservoirs of CCHFV, but in fact they develop only a transient viremia, while the virus can persist in ticks for their entire lifespan, and can also be transmitted vertically to the next generation...
June 1, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28575000/clinical-and-virological-characteristics-of-dengue-in-surabaya-indonesia
#15
Puspa Wardhani, Aryati Aryati, Benediktus Yohan, Hidayat Trimarsanto, Tri Y Setianingsih, Dwiyanti Puspitasari, Muhammad Vitanata Arfijanto, Bramantono Bramantono, Suharto Suharto, R Tedjo Sasmono
Dengue disease is still a major health problem in Indonesia. Surabaya, the second largest city in the country, is endemic for dengue. We report here on dengue disease in Surabaya, investigating the clinical manifestations, the distribution of dengue virus (DENV) serotypes, and the relationships between clinical manifestations and the genetic characteristics of DENV. A total of 148 patients suspected of having dengue were recruited during February-August 2012. One hundred one (68%) of them were children, and 47 (32%) were adults...
2017: PloS One
https://www.readbyqxmd.com/read/28574091/macrocyclic-peptide-inhibitors-for-the-protein-protein-interaction-of-zaire-ebola-virus-protein-24-and-karyopherin-alpha-5
#16
Xiao Song, Lu-Yi Lu, Toby Passioura, Hiroaki Suga
Ebola virus infection leads to severe hemorrhagic fever in human and non-human primates with an average case fatality rate of 50%. To date, numerous potential therapies are in development, but FDA-approved drugs or vaccines are yet unavailable. Ebola viral protein 24 (VP24) is a multifunctional protein that plays critical roles in the pathogenesis of Ebola virus infection, e.g. innate immune suppression by blocking the interaction between KPNA and PY-STAT1. Here we report macrocyclic peptide inhibitors of the VP24-KPNA5 protein-protein interaction (PPI) by means of the RaPID (Random non-standard Peptides Integrated Discovery) system...
June 21, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28573620/luciferase-expressing-ebolaviruses-as-tools-for-screening-of-antivirals
#17
Thomas Hoenen
Ebolaviruses cause severe hemorrhagic fever with high case fatality rates. Despite recent progress, there is a continued need for the development of antivirals against these viruses. Reporter-expressing ebolaviruses, which can be generated using reverse genetics systems, are powerful tools for antiviral screening. While viruses expressing fluorescent reporters are amenable for this purpose and can be used for high-content imaging-type screens, as an alternative, luciferase-expressing reporter viruses have recently been developed and have the advantages of being extremely easy to use and having short assay times...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28573615/modeling-the-ebolavirus-life-cycle-with-transcription-and-replication-competent-viruslike-particle-assays
#18
Nadine Biedenkopf, Thomas Hoenen
Ebolaviruses are the causative agent of a severe hemorrhagic fever with high case fatality rates, for which no approved specific therapy is available. As biosafety level 4 (BSL4) agents, work with live ebolaviruses is restricted to maximum containment laboratories. Transcription and replication-competent viruslike particle (trVLP) systems are reverse genetics-based life cycle modeling systems that allow researchers to model virtually the entire ebolavirus life cycle outside of a maximum containment laboratory...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28573609/ebolavirus-an-overview-of-molecular-and-clinical-pathogenesis
#19
Veronica Vine, Dana P Scott, Heinz Feldmann
Ebolaviruses cause severe, often fatal hemorrhagic fever in Central, East, and West Africa. Until recently, they have been viewed as rare but highly pathogenic infections with regional, but limited, global public health impact. This view has changed with the emergence of the first epidemic of Ebola hemorrhagic fever in West Africa. In this chapter we provide an introduction of the pathogenesis of ebolaviruses as well as a description of clinical disease features. We also describe the current animal models used in ebolavirus research, detailing each model's unique strengths and weaknesses...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28572804/serum-cytokine-profiles-differentiating-hemorrhagic-fever-with-renal-syndrome-and-hantavirus-pulmonary-syndrome
#20
Svetlana F Khaiboullina, Silvana Levis, Sergey P Morzunov, Ekaterina V Martynova, Vladimir A Anokhin, Oleg A Gusev, Stephen C St Jeor, Vincent C Lombardi, Albert A Rizvanov
Hantavirus infection is an acute zoonosis that clinically manifests in two primary forms, hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). HFRS is endemic in Europe and Russia, where the mild form of the disease is prevalent in the Tatarstan region. HPS is endemic in Argentina, as well as other countries of North and South American. HFRS and HPS are usually acquired via the upper respiratory tract by inhalation of virus-contaminated aerosol. Although the pathogenesis of HFRS and HPS remains largely unknown, postmortem tissue studies have identified endothelial cells as the primary target of infection...
2017: Frontiers in Immunology
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