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Hemorrhagic Fever viruses

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https://www.readbyqxmd.com/read/29135337/dna-vaccines-elicit-durable-protective-immunity-against-individual-or-simultaneous-infections-with-lassa-and-ebola-viruses-in-guinea-pigs
#1
Kathleen A Cashman, Eric R Wilkinson, Suzanne E Wollen, Joshua D Shamblin, Justine M Zelko, Jeremy J Bearss, Xiankun Zeng, Kate E Broderick, Connie S Schmaljohn
We previously developed optimized DNA vaccines against both Lassa fever and Ebola hemorrhagic fever viruses and demonstrated that they were protective individually in guinea pig and nonhuman primate models. In this study, we vaccinated groups of strain 13 guinea pigs two times, four weeks apart with 50 µg of each DNA vaccine or a mock vaccine at discrete sites by intradermal electroporation. Five weeks following the second vaccinations, guinea pigs were exposed to lethal doses of Lassa virus, Ebola virus, or a combination of both viruses simultaneously...
November 14, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29128378/ebola-virus-disease-report-from-the-task-force-on-tropical-diseases-by-the-world-federation-of-societies-of-intensive-and-critical-care-medicine
#2
REVIEW
Guy A Richards, Tim Baker, Pravin Amin
Ebola virus is a filovirus that can cause fatal hemorrhagic fever (HF) and five distinct species exist that vary in terms of geographical distribution and virulence. Once the more virulent forms enter the human population, transmission occurs primarily through direct contact with infected body fluids and may result in significant outbreaks. The devastating has been the recent West African outbreak. Clinically, signs and symptoms are similar to those of the other VHFs [4]. The incubation period is 2-21days, followed by fever, headache, myalgia, diarrhoea, vomiting and dehydration; thereafter, there may be recovery or deterioration with collapse, neurological manifestations and bleeding, that can lead to a fatal outcome...
November 3, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/29128377/viral-hemorrhagic-fever-in-the-tropics-report-from-the-task-force-on-tropical-diseases-by-the-world-federation-of-societies-of-intensive-and-critical-care-medicine
#3
REVIEW
Jorge Luis Hidalgo Marroquin, Guy A Richards, Juan Ignacio Silesky Jiménez, Tim Baker, Pravin Amin
Viral hemorrhagic fevers (VHFs) are a group of illnesses caused by four families of viruses namely Arenaviruses, Filoviruses, Bunyaviruses, and Flaviviruses. Humans are not the natural reservoir for any of these organisms and acquire the disease through vectors from animal reservoirs. In some conditions human to human transmission is possible increasing the risk to healthy individuals in the vicinity, more so to Health Care Workers (HCW). The pathogenesis of VHF, though poorly understood, varies according to the viruses involved...
November 4, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/29120740/breaking-the-barrier-host-cell-invasion-by-lujo-virus
#4
Stefan Kunz, Juan Carlos de la Torre
Lujo virus (LUJV) is an arenavirus that emerged in 2008 associated with a cluster of human cases of severe hemorrhagic fever. In this issue of Cell Host & Microbe, Raaben et al. (2017) identify neuropilin (NRP)-2 as cell surface receptor and the tetraspannin protein CD63 as intracellular entry factor for LUJV.
November 8, 2017: Cell Host & Microbe
https://www.readbyqxmd.com/read/29118655/the-burden-of-dengue-source-reduction-measures-and-serotype-patterns-in-myanmar-2011-to-2015-r2
#5
Pwint Mon Oo, Khin Thet Wai, Anthony D Harries, Hemant Deepak Shewade, Tin Oo, Aung Thi, Zaw Lin
Background: Myanmar is currently classified as a high burden dengue country in the Asian Pacific region. The Myanmar vector-borne diseases control (VBDC) program has collected data on dengue and source reduction measures since 1970, and there is a pressing need to collate, analyze, and interpret this information. The aim of this study was to describe the burden of hospital-based dengue disease, dengue control measures, and serotype patterns in Myanmar between 2011 and 2015. Methods: This was a cross-sectional study using annual records from the Dengue Fever/Dengue Hemorrhagic Fever Prevention and Control Project in Myanmar...
2017: Tropical Medicine and Health
https://www.readbyqxmd.com/read/29117665/application-of-therapeutic-plasma-exchange-in-patients-having-severe-fever-with-thrombocytopenia-syndrome
#6
Jeong Rae Yoo, Sun Hyung Kim, Young Ree Kim, Keun Hwa Lee, Won Sup Oh, Sang Taek Heo
Background/Aims: Severe fever with thrombocytopenia syndrome (SFTS) is a viral hemorrhagic fever with a high fatality rate. However, effective treatments for SFTS cases not responded to supportive therapy have not been established. Herein, we introduced the therapeutic plasma exchange (TPE) in SFTS patients in a tertiary hospital between 2013 and 2015. Methods: TPE was performed in patients with rapidly progressing SFTS. Clinical, laboratory, and virological parameters were compared before and after TPE...
November 10, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29105052/differences-in-activation-and-tissue-homing-markers-of-natural-killer-cell-subsets-during-acute-dengue-infection
#7
Rassamon Keawvichit, Ladawan Khowawisetsut, Sakaorat Lertjuthaporn, Kanchana Tangnararatchakit, Nopporn Apiwattanakul, Sutee Yoksan, Ampaiwan Chuansumrit, Kulkanya Chokephaibulkit, Aftab A Ansari, Nattawat Onlamoon, Kovit Pattanapanyasat
Dengue virus (DENV) infection is considered as one of the most important mosquito-borne diseases. It causes a spectrum of illness that could be due to qualitative and/or quantitative difference(s) of the natural killer (NK)-cell responses during acute DENV infection. This view prompted us to perform a detailed phenotypic comparative characterization of NK cell subsets from DENV-infected patients with dengue fever (DF), dengue hemorrhagic fever (DHF) and healthy controls. The activation/differentiation molecules, CD69 and CD57 and a variety of tissue homing molecules were analyzed on the CD56(hi) CD16(-) and CD56(lo) CD16(+) NK cells...
November 4, 2017: Immunology
https://www.readbyqxmd.com/read/29103866/-an-uncommon-complication-of-dengue
#8
Manan Mehta, Praveen Kumar Sharma, Ravindra Kumar Garg
Intracranial hemorrhage is an uncommon complication of dengue fever, which is caused by a flavivirus and transmitted via Aedes mosquito. We present here bilateral cerebellar bleed because of dengue virus infection.
November 2, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29103686/pathogenicity-of-a-newly-emerged-recombined-porcine-reproductive-and-respiratory-syndrome-virus-strain-subgenotype-iii-in-china
#9
Jianguo Dong, Yanwu Wang, Linyang Yu, Pengfei Zhang, Xiangcong Liu, Leyi Zhang, Yanling Liu, Pengshuai Liang, Lei Wang, Changxu Song
Porcine reproductive and respiratory syndrome virus (PRRSV) is a severe pathogen that causes enormous economic losses to the swine industry worldwide. Since its first report in the 1980s, PRRSV has undergone extensive variation. In the previous study, we demonstrated that the GDsg strain was a new recombined virus between the low pathogenic field strain QYYZ and the vaccine strain JXA1-P80, belonging to the newly emerging type 2 PRRSV subgenotype III. In this study, the pathogenicity of a new recombined strain GDsg for pigs was analyzed...
October 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/29093311/experiences-of-response-measures-against-the-4-suspected-cases-of-ebola-virus-disease-from-west-africa-in-the-national-center-for-global-health-and-medicine-tokyo-japan
#10
Satoshi Kutsuna, Kei Yamamoto, Nozomi Takeshita, Kayoko Hayakawa, Yasuyuki Kato, Shuzo Kanagawa, Yuko Sugiki, Norio Ohmagari
In Japan, infectious diseases are classified into 4 types based on how contagious and severe the pathogens are, and Ebola virus disease (EVD) is categorized as a category 1 infectious disease. National Center for Global Health and Medicine in Tokyo, Japan, is designated as a specified hospital for category 1 infectious disease patients, and has experienced 4 probable cases of EVD from West Africa. Even after the end of the outbreak in West Africa, we should continue to pay attention for new EVD outbreaks. To increase the number of the infectious disease specialist with the proper knowledge of viral hemorrhagic fever including EVD is a common problem for infectious disease physicians working in Japan, the academic society, and the government...
October 31, 2017: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29091325/dynamics-of-viral-load-in-crimean-congo-hemorrhagic-fever
#11
Imran Hasanoglu, Rahmet Guner, Ahmet Carhan, Zeliha Kocak Tufan, Dilek Yagci Caglayik, Gul Ruhsar Yilmaz, Mehmet Akin Tasyaran
Crimean Congo hemorrhagic fever (CCHF) is a viral zoonotic disease with high mortality rate. There are only a few studies on viral load in CCHF. In our study, we revealed the dynamics of viral load and its relationship with mortality in early phase of the disease. A total of 138 serum samples were collected from 23 patients. All patients had positive PCR for CCHF on admission. Serum samples were obtained daily from all patients for the first 6 days of hospitalization and stored at -80°C for viral load measurement...
November 1, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/29081359/apoptosis-during-arenavirus-infection-mechanisms-and-evasion-strategies
#12
REVIEW
Bjoern Meyer, Allison Groseth
In recent years there has been a greatly increased interest in the interactions of arenaviruses with the apoptotic machinery, and particularly the extent to which these interactions may be an important contributor to pathogenesis. Here we summarize the current state of our knowledge on this subject and address the potential for interplay with other immunological mechanisms known to be regulated by these viruses. We also compare and contrast what is known for arenavirus-induced apoptosis with observations from other segmented hemorrhagic fever viruses...
October 28, 2017: Microbes and Infection
https://www.readbyqxmd.com/read/29078811/dengue-hemorrhagic-fever-complicated-with-transient-diabetic-ketoacidosis-a-case-report
#13
Chamara Dalugama, Indika Bandara Gawarammana
BACKGROUND: The increasing global prevalence of both dengue and diabetes may warrant closer observation for glycemic control and adapted fluid management to diminish the risk for a severe clinical presentation of dengue. Dengue illness is rarely known to precipitate diabetic ketoacidosis among diabetic patients. Both type 1 and type 2 diabetes increase the release of pro-inflammatory cytokines by various mechanisms and increase the risk of plasma leak in dengue fever. Acute pancreatitis is an atypical and rare presentation of dengue fever...
October 28, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29073030/expanded-subgenomic-mrna-transcriptome-and-coding-capacity-of-a-nidovirus
#14
Han Di, Joseph C Madden, Esther K Morantz, Hsin-Yao Tang, Rachel L Graham, Ralph S Baric, Margo A Brinton
Members of the order Nidovirales express their structural protein ORFs from a nested set of 3' subgenomic mRNAs (sg mRNAs), and for most of these ORFs, a single genomic transcription regulatory sequence (TRS) was identified. Nine TRSs were previously reported for the arterivirus Simian hemorrhagic fever virus (SHFV). In the present study, which was facilitated by next-generation sequencing, 96 SHFV body TRSs were identified that were functional in both infected MA104 cells and macaque macrophages. The abundance of sg mRNAs produced from individual TRSs was consistent over time in the two different cell types...
October 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29070682/epistastic-interactions-within-the-jun%C3%A3-n-virus-envelope-glycoprotein-complex-provide-an-evolutionary-barrier-to-reversion-in-the-live-attenuated-candid-1-vaccine
#15
Joanne York, Jack H Nunberg
The Candid#1 strain of Junín virus was developed using a conventional attenuation strategy of serial passage in non-host animals and cultured cells. The live-attenuated Candid#1 vaccine is used in Argentina to protect at-risk individuals against Argentine hemorrhagic fever, but has not been licensed in the United States. Recent studies have revealed that Candid#1 attenuation is entirely dependent on a phenylalanine-to-isoleucine substitution at position 427 in the fusion subunit (GP2) of the viral envelope glycoprotein complex (GPC), thereby raising concerns regarding the potential for reversion to virulence...
October 25, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29070018/hemorrhagic-hypopyon-as-presenting-feature-of-intravascular-lymphoma-a-case-report
#16
Andrew Winegarner, Noriyasu Hashida, Shizuka Koh, Kohji Nishida
BACKGROUND: Herpes uveitis has been previously reported to present with hyphema, but hemorrhagic hypopyon is rarely reported as a herpetic uveitis manifestation. We report a case of herpes simplex virus (HSV) presenting with hemorrhagic hypopyon, and speculate on the underlying pathophysiology with relation to an intravascular lymphoma which was subsequently diagnosed as a result. CASE PRESENTATION: We present a case wherein a 62-year-old Japanese rheumatoid arthritis woman, with HSV uveitis, presented with hemorrhagic hypopyon in the anterior chamber and a fever with photophobia...
October 25, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/29054571/associations-of-dc-sign-cd209-promoter-336g-a-polymorphism-rs4804803-with-dengue-infection-a-systematic-review-and-meta-analysis
#17
Noel Pabalan, Suwit Chaisri, Sompong Tabunhan, Achara Phumyen, Hamdi Jarjanazi, Theodore S Steiner
BACKGROUND AND AIM: Dengue virus entry into a host is associated with a cell surface protein, DC-SIGN (dendritic cell-specific intercellular adhesion molecule-3 grabbing non-integrin). A common CD209-336G/A (rs4804803) polymorphism in DC-SIGN may affect severity of dengue virus infection (DEN) and incidence of dengue fever (DF) or the more severe dengue hemorrhagic fever (DHF). However, the reported associations of these two outcomes and CD-209 have been inconsistent, which prompted a meta-analysis to obtain more precise estimates...
October 18, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29051241/genome-sequences-of-crimean-congo-hemorrhagic-fever-virus-strains-isolated-in-south-africa-namibia-and-turkey
#18
Marko Zivcec, Cesar G Albarino, Lisa I W Guerrero, Thomas G Ksiazek, Stuart T Nichol, Robert Swanepoel, Pierre E Rollin, Christina F Spiropoulou
We report here the full-length sequences of 16 historical isolates of Crimean-Congo hemorrhagic fever orthonairovirus (CCHFV) obtained in Turkey, Namibia, and South Africa. The strains may be useful for future work to develop molecular diagnostics or viral evolution studies.
October 19, 2017: Genome Announcements
https://www.readbyqxmd.com/read/29045192/a-dna-vaccine-delivered-by-dermal-electroporation-fully-protects-cynomolgus-macaques-against-lassa-fever
#19
Kathleen A Cashman, Eric R Wilkinson, Carl I Shaia, Paul R Facemire, Todd M Bell, Jeremy J Bearss, Joshua D Shamblin, Suzanne E Wollen, Kate E Broderick, Niranjan Y Sardesai, Connie S Schmaljohn
Lassa virus (LASV) is an ambisense RNA virus in the Arenaviridae family and is the etiological agent of Lassa fever, a severe hemorrhagic disease endemic to West and Central Africa. (1,2) There are no US Food and Drug Administration (FDA)-licensed vaccines available to prevent Lassa fever. (1,2) in our previous studies, we developed a gene-optimized DNA vaccine that encodes the glycoprotein precursor gene of LASV (Josiah strain) and demonstrated that 3 vaccinations accompanied by dermal electroporation protected guinea pigs from LASV-associated illness and death...
October 18, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29044009/-stability-of-candid-1-vaccine-to-prevent-argentine-hemorrhagic-fever
#20
María Del Carmen Saavedra, Laura M Riera, Alejandro J Bottale, Mauricio A Mariani, Andrea S Maiza, Ana María Ambrosio
Candid#1 is the first live attenuated vaccine produced and registered in Argentina. Produced since 2003 at the INEVH to prevent Argentine hemorrhagic fever, it is obtained by harvesting supernatants of diploid cells infected with an attenuated strain of Junin virus and subsequent lyophilization. The stability of this vaccine is crucial to ensure its effectiveness. This study was aimed to evaluate the stability of Candid#1 by exposing it to different time and temperature conditions. Three vaccine batches produced in 2003 were analysed according to the following storage scheme: (a) reconstituted vaccine at 2 °C to 8 °C for 8 days; (b) lyophilized vaccine at 2 °C to 8 °C for 6 months; (c) lyophilized vaccine at -18 °C to -20 °C for 10 years...
2017: Medicina
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