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Hemorrhagic Fever viruses

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https://www.readbyqxmd.com/read/29774860/importation-of-human-seoul-virus-infection-to-germany-from-indonesia
#1
Jörg Hofmann, Sabrina Weiss, Martin Kuhns, Annekathrin Zinke, Heike Heinsberger, Detlev H Kruger
Seoul hantavirus-associated hemorrhagic fever with renal syndrome cases are rare outside Asia and have not yet been found in Germany. We report clinical and molecular evidence for a Seoul virus infection in a patient in Germany. The infection was most likely acquired during a stay in Sulawesi, Indonesia.
June 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29768655/let-7e-inhibits-tnf-%C3%AE-expression-by-targeting-the-methyl-transferase-ezh2-in-denv2-infected-thp-1-cells
#2
Yingke Zhang, Qianqian Zhang, Lian Gui, Yan Cai, Xiaohong Deng, Cheukfai Li, Qi Guo, Xiaoshun He, Junqi Huang
Tumor necrosis factor α (TNFα), an important inflammatory cytokine, is associated with dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS), a severe pathological manifestation of dengue virus (DENV) infection. However, the regulatory mechanism of microRNA on TNFα is currently unknown. Our study showed that the TNFα expression increased immediately and then later decreased, while a marked increase for the miRNA let-7e was detected in dengue virus type 2 (DENV2)-infected peripheral blood mononuclear cells (PBMCs)...
May 16, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29765118/ifn-%C3%AE-s-inhibit-hantaan-virus-infection-through-the-jak-stat-pathway-and-expression-of-mx2-protein
#3
Ning Li, Fan Luo, Qingzhou Chen, Ni Zhu, Hui Wang, Linlin Xie, Hairong Xiong, Ming Yue, Yun Zhang, Yong Feng, Wei Hou
Hantaan virus (HTNV), member of the newly defined Hantaviridae family, within the order Bunyavirales, can cause a hemorrhagic fever with renal syndrome with high fatality rates in humans. However, no specific antiviral agents are currently available for HTNV infection approved by the US Food and Drug Administration. Although interferon lambdas (IFN-λs) have been shown to induce an antiviral state against HTNV, the molecular mechanisms remain to be determined. In this study, we found that IFN-λs exerted its anti-HTNV effect by activating Janus kinase/signal transducers and activators of transcription (JAK-STAT) pathway-mediated antiviral immunity in A549 cells...
May 15, 2018: Genes and Immunity
https://www.readbyqxmd.com/read/29765019/relationship-between-circulating-vascular-endothelial-growth-factor-and-its-soluble-receptor-in-patients-with-hemorrhagic-fever-with-renal-syndrome
#4
Emil Pal, Misa Korva, Katarina Resman Rus, Nataša Kejžar, Petra Bogovič, Franc Strle, Tatjana Avšič-Županc
Hemorrhagic fever with renal syndrome (HFRS) is characterized by endothelial dysfunction with capillary leakage without obvious cytopathology in the capillary endothelium. The aim of the study was to analyze the kinetics of vascular endothelial growth factor (VEGF) and its soluble receptor (sVEGFR-2) in HFRS patients infected with Dobrava (DOBV) or Puumala virus (PUUV). VEGF and sVEGFR-2 levels were measured in daily plasma and urine samples of 73 patients with HFRS (58 with PUUV, 15 with DOBV) and evaluated in relation to clinical and laboratory variables...
May 16, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29760382/vaccine-elicited-receptor-binding-site-antibodies-neutralize-two-new-world-hemorrhagic-fever-arenaviruses
#5
Lars E Clark, Selma Mahmutovic, Donald D Raymond, Taleen Dilanyan, Takaaki Koma, John T Manning, Sundaresh Shankar, Silvana C Levis, Ana M Briggiler, Delia A Enria, Kai W Wucherpfennig, Slobodan Paessler, Jonathan Abraham
While five arenaviruses cause human hemorrhagic fevers in the Western Hemisphere, only Junin virus (JUNV) has a vaccine. The GP1 subunit of their envelope glycoprotein binds transferrin receptor 1 (TfR1) using a surface that substantially varies in sequence among the viruses. As such, receptor-mimicking antibodies described to date are type-specific and lack the usual breadth associated with this mode of neutralization. Here we isolate, from the blood of a recipient of the live attenuated JUNV vaccine, two antibodies that cross-neutralize Machupo virus with varying efficiency...
May 14, 2018: Nature Communications
https://www.readbyqxmd.com/read/29753850/role-of-mitogen-activated-protein-kinase-signaling-in-the-pathogenesis-of-dengue-virus-infection
#6
REVIEW
Gopinathan Pillai Sreekanth, Pa-Thai Yenchitsomanus, Thawornchai Limjindaporn
Dengue virus (DENV) infection is a disease that is endemic to many parts of the world, and its increasing prevalence ranks it among the diseases considered to be a significant threat to public health. The clinical manifestations of DENV infection range from mild dengue fever (DF) to more severe dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). Increased proinflammatory cytokines and vascular permeability, both of which cause organ injury, are the hallmarks of severe dengue disease. Signs of liver injury were observed in studies using hepatic cell lines, mouse models, and autopsy specimens from DENV-infected patients, and these signs substantiated the effects of inflammatory responses and hepatic cell apoptosis...
May 10, 2018: Cellular Signalling
https://www.readbyqxmd.com/read/29751873/acute-viral-hepatitis-beyond-a-b-and-c
#7
REVIEW
Venancio Avancini Ferreira Alves
From the standpoint of the surgical pathologist "hepatitis" is defined as the set of histologic patterns of lesions found in livers infected by hepatotropic viruses, by non-hepatotrophic viruses leading to liver inflammation in the context of systemic infection, or due to an autoimmune disease, drug, or toxin involving the liver. This article is centered on the histologic patterns of injury in acute viral hepatitis, encompassing the hepatotropic viruses A, B, C, D, and E and the "icteric hemorrhagic fevers" (dengue, hantavirus, yellow fever)...
June 2018: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/29745301/comparative-genome-analysis-of-alkhumra-hemorrhagic-fever-virus-with-kyasanur-forest-disease-and-tick-borne-encephalitis-viruses-by-the-in-silico-approach
#8
Navaneethan Palanisamy, Dario Akaberi, Johan Lennerstrand, Åke Lundkvist
Alkhumra hemorrhagic fever virus (AHFV), a relatively new member of the Flaviviruses, was discovered in Saudi Arabia 23 years ago. AHFV is classified in the tick-borne encephalitis virus serocomplex, along with the Kyasanur forest disease virus (KFDV) and tick-borne encephalitis virus (TBEV). Currently, very little is known about the pathologies of AHFV. In this study, using the available genome information of AHFV, KFDV and TBEV, we have predicted and compared the following aspects of these viruses: evolution, nucleotide and protein compositions, recombination, codon frequency, substitution rate, N- and O-glycosylation sites, signal peptide and cleavage site, transmembrane region, secondary structure of 5' and 3' UTRs and RNA-RNA interactions...
May 10, 2018: Pathogens and Global Health
https://www.readbyqxmd.com/read/29743115/geographical-distribution-and-relative-risk-of-anjozorobe-virus-thailand-orthohantavirus-infection-in-black-rats-rattus-rattus-in-madagascar
#9
Vololoniaina Raharinosy, Marie-Marie Olive, Fehivola Mandanirina Andriamiarimanana, Soa Fy Andriamandimby, Jean-Pierre Ravalohery, Seta Andriamamonjy, Claudia Filippone, Danielle Aurore Doll Rakoto, Sandra Telfer, Jean-Michel Heraud
BACKGROUND: Hantavirus infection is a zoonotic disease that is associated with hemorrhagic fever with renal syndrome and cardiopulmonary syndrome in human. Anjozorobe virus, a representative virus of Thailand orthohantavirus (THAIV), was recently discovered from rodents in Anjozorobe-Angavo forest in Madagascar. To assess the circulation of hantavirus at the national level, we carried out a survey of small terrestrial mammals from representative regions of the island and identified environmental factors associated with hantavirus infection...
May 9, 2018: Virology Journal
https://www.readbyqxmd.com/read/29727450/rift-valley-fever-viral-load-correlates-with-the-human-inflammatory-response-and-coagulation-pathway-abnormalities-in-humans-with-hemorrhagic-manifestations
#10
Annabelle de St Maurice, Jessica Harmon, Luke Nyakarahuka, Stephen Balinandi, Alex Tumusiime, Jackson Kyondo, Sophia Mulei, Annemarion Namutebi, Barbara Knust, Trevor Shoemaker, Stuart T Nichol, Anita K McElroy, Christina F Spiropoulou
Rift Valley fever virus is an arbovirus that affects both livestock and humans throughout Africa and in the Middle East. Despite its endemicity throughout Africa, it is a rare event to identify an infected individual during the acute phase of the disease and an even rarer event to collect serial blood samples from the affected patient. Severely affected patients can present with hemorrhagic manifestations of disease. In this study we identified three Ugandan men with RVFV disease that was accompanied by hemorrhagic manifestations...
May 4, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29724035/involvement-of-pro-inflammatory-macrophages-in-liver-pathology-of-pirital-virus-infected-syrian-hamsters
#11
Corey L Campbell, Aaron T Phillips, Amber Rico, Amanda McGuire, Tawfik A Aboellail, Sandra Quackenbush, Ken E Olson, Tony Schountz
New World arenaviruses cause fatal hemorrhagic disease in South America. Pirital virus (PIRV), a mammarenavirus hosted by Alston’s cotton rat ( Sigmodon alstoni ), causes a disease in Syrian golden hamsters ( Mesocricetus auratus ) (biosafety level-3, BSL-3) that has many pathologic similarities to the South American hemorrhagic fevers (BSL-4) and, thus, is considered among the best small-animal models for human arenavirus disease. Here, we extend in greater detail previously described clinical and pathological findings in Syrian hamsters and provide evidence for a pro-inflammatory macrophage response during PIRV infection...
May 2, 2018: Viruses
https://www.readbyqxmd.com/read/29720525/antibodies-to-the-glycoprotein-gp2-subunit-cross-react-between-old-and-new-world-arenaviruses
#12
Fatima Amanat, James Duehr, Lisa Oestereich, Kathryn M Hastie, Erica Ollmann Saphire, Florian Krammer
Arenaviruses pose a major public health threat and cause numerous infections in humans each year. Although most viruses belonging to this family do not cause disease in humans, some arenaviruses, such as Lassa virus and Machupo virus, are the etiological agents of lethal hemorrhagic fevers. The absence of a currently licensed vaccine and the highly pathogenic nature of these viruses both make the necessity of developing viable vaccines and therapeutics all the more urgent. Arenaviruses have a single glycoprotein on the surface of virions, the glycoprotein complex (GPC), and this protein can be used as a target for vaccine development...
June 27, 2018: MSphere
https://www.readbyqxmd.com/read/29719780/establishment-of-pseudovirus-infection-mouse-models-for-in-vivo-pharmacodynamics-evaluation-of-filovirus-entry-inhibitors
#13
Qing Chen, Ke Tang, Xiaoyu Zhang, Panpan Chen, Ying Guo
Filoviruses cause severe and fatal viral hemorrhagic fever in humans. Filovirus research has been extensive since the 2014 Ebola outbreak. Due to their high pathogenicity and mortality, live filoviruses require Biosafety Level-4 (BSL-4) facilities, which have restricted the development of anti-filovirus vaccines and drugs. An HIV-based pseudovirus cell infection assay is widely used for viral entry studies in BSL-2 conditions. Here, we successfully constructed nine in vitro pseudo-filovirus models covering all filovirus genera and three in vivo pseudo-filovirus-infection mouse models using Ebola virus, Marburg virus, and Lloviu virus as representative viruses...
March 2018: Acta Pharmaceutica Sinica. B
https://www.readbyqxmd.com/read/29718685/vector-competence-of-certain-culex-and-aedes-mosquitoes-for-the-chittoor-virus-the-indian-variant-of-batai-virus
#14
Anakkathil Balan Sudeep, Neda Shaikh, Youwaraj Ghodke, Viswas Ingale, Mangesh Gokhale
Chittoor virus (CHITV), a mosquito-borne bunyavirus (Orthobunyavirus: Bunyaviridae) isolated in India, has been found to be antigenically close to the Batai virus (BATV),which has a wide distribution across Asia, Europe and Africa. The latter causes influenza-like illness in humans and mild illness in sheep and goats. BATV has been involved in genetic reassortment with other bunyaviruses, generating novel genome combinations and causing severe clinical manifestations including hemorrhagic fever. Conversely, CHITV has never been associated with any major outbreaks in India, although neutralizing antibodies have been detected in humans and domestic animals...
May 2, 2018: Canadian Journal of Microbiology
https://www.readbyqxmd.com/read/29715287/multisectoral-prioritization-of-zoonotic-diseases-in-uganda-2017-a-one-health-perspective
#15
Musa Sekamatte, Vikram Krishnasamy, Lilian Bulage, Christine Kihembo, Noelina Nantima, Fred Monje, Deo Ndumu, Juliet Sentumbwe, Betty Mbolanyi, Robert Aruho, Winyi Kaboyo, David Mutonga, Colin Basler, Sarah Paige, Casey Barton Behravesh
BACKGROUND: Zoonotic diseases continue to be a public health burden globally. Uganda is especially vulnerable due to its location, biodiversity, and population. Given these concerns, the Ugandan government in collaboration with the Global Health Security Agenda conducted a One Health Zoonotic Disease Prioritization Workshop to identify zoonotic diseases of greatest national concern to the Ugandan government. MATERIALS AND METHODS: The One Health Zoonotic Disease Prioritization tool, a semi-quantitative tool developed by the U...
2018: PloS One
https://www.readbyqxmd.com/read/29709562/novel-cyclo-peptides-inhibit-ebola-pseudotyped-virus-entry-by-targeting-primed-gp-protein
#16
Quanjie Li, Ling Ma, Dongrong Yi, Han Wang, Jing Wang, Yongxin Zhang, Ying Guo, Xiaoyu Li, Jinming Zhou, Yi Shi, George F Gao, Shan Cen
Ebola virus (EBOV) causes fatal hemorrhagic fever with high death rates in human. Currently, there are no available clinically-approved prophylactic or therapeutic treatments. The recently solved crystal structure of cleavage-primed EBOV glycoprotein (GPcl) in complex with the C domain of endosomal protein Niemann-Pick C1 (NPC1) provides a new target for the development of EBOV entry inhibitors. In this work, a computational approach using docking and molecular dynamic simulations is carried out for the rational design of peptide inhibitors...
April 27, 2018: Antiviral Research
https://www.readbyqxmd.com/read/29706314/dengue-haemorrhagic-fever-an-emerging-disease-in-nigeria-west-africa
#17
REVIEW
Ademola Hezekiah Fagbami, Anyebe Bernard Onoja
INTRODUCTION: In Nigeria, dengue fever caused by dengue virus, types 1 and 2 has been diagnosed for many years. Although, seroepidemiological surveys have shown that dengue virus activity is, widespread in the country, there is scanty information on dengue, hemorrhagic fever with little attention paid to dengue fever largely, because it presents as classical dengue fever characterized by fever, myalgia, headache, arthralgia, retro-orbital pain, gastro intestinal, symptoms and skin rash...
April 26, 2018: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/29705070/novel-insights-into-cell-entry-of-emerging-human-pathogenic-arenaviruses
#18
REVIEW
Chiara Fedeli, Hector Moreno, Stefan Kunz
Viral hemorrhagic fevers (VHF) caused by emerging RNA viruses of the Arenavirus family are among the most devastating human diseases. Climate change, global trade, and increasing urbanization promote the emergence and re-emergence of these human pathogenic viruses. Emerging pathogenic arenaviruses are of zoonotic origin and reservoir-to-human transmission is crucial for spillover into human populations. Host cell attachment and entry are the first and most fundamental steps of every virus infection and represent major barriers for zoonotic transmission...
April 26, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29692780/genome-wide-analysis-to-identify-hla-factors-potentially-associated-with-severe-dengue
#19
Sudheer Gupta, Ankita Agarwal, Amod Kumar, Debasis Biswas
The pathogenesis of dengue hemorrhagic fever (DHF), following dengue virus (DENV) infection, is a complex and poorly understood phenomenon. In view of the clinical need of identifying patients with higher likelihood of developing this severe outcome, we undertook a comparative genome-wide association analysis of epitope variants from sequences available in the ViPR database that have been reported to be differentially related to dengue fever and DHF. Having enumerated the incriminated epitope variants, we determined the corresponding HLA alleles in the context of which DENV infection could potentially precipitate DHF...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29691416/virus-encoded-mirnas-in-ebola-virus-disease
#20
Janice Duy, Anna N Honko, Louis A Altamura, Sandra L Bixler, Suzanne Wollen-Roberts, Nadia Wauquier, Aileen O'Hearn, Eric M Mucker, Joshua C Johnson, Joshua D Shamblin, Justine Zelko, Miriam A Botto, James Bangura, Moinya Coomber, M Louise Pitt, Jean-Paul Gonzalez, Randal J Schoepp, Arthur J Goff, Timothy D Minogue
Ebola virus (EBOV) is a negative-strand RNA virus that replicates in the cytoplasm and causes an often-fatal hemorrhagic fever. EBOV, like other viruses, can reportedly encode its own microRNAs (miRNAs) to subvert host immune defenses. miRNAs are short noncoding RNAs that can regulate gene expression by hybridizing to multiple mRNAs, and viral miRNAs can enhance viral replication and infectivity by regulating host or viral genes. To date, only one EBOV miRNA has been examined in human infection. Here, we assayed mouse, rhesus macaque, cynomolgus macaque, and human samples infected with three EBOV variants for twelve computationally predicted viral miRNAs using RT-qPCR...
April 24, 2018: Scientific Reports
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