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Hemorrhagic Fever viruses

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https://www.readbyqxmd.com/read/28086865/rnai-reveals-proteins-for-metabolism-and-protein-processing-associated-with-langat-virus-infection-in-ixodes-scapularis-black-legged-tick-ise6-cells
#1
Jeffrey M Grabowski, Monika Gulia-Nuss, Richard J Kuhn, Catherine A Hill
BACKGROUND: Tick-borne flaviviruses (TBFs) cause thousands of human cases of encephalitis worldwide each year, with some TBF infections progressing to hemorrhagic fever. TBFs are of medical and veterinary importance and strategies to reduce flavivirus transmission by the tick vector may have significant application. Analyses of the proteome of ISE6 cells derived from the black legged tick, Ixodes scapularis infected with the TBF, Langat virus (LGTV), have provided insights into proteins and cellular processes involved with LGTV infection...
January 13, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28077582/severity-of-plasma-leakage-is-associated-with-high-levels-of-interferon-%C3%AE-inducible-protein-10-hepatocyte-growth-factor-matrix-metalloproteinase-2-mmp-2-and-mmp-9-during-dengue-virus-infection
#2
Zhisheng Her, Yiu-Wing Kam, Victor C Gan, Bernett Lee, Tun-Linn Thein, Jeslin J L Tan, Linda K Lee, Katja Fink, David C Lye, Laurent Rénia, Yee-Sin Leo, Lisa F P Ng
BACKGROUND:  Dengue virus infection typically causes mild dengue fever, but, in severe cases, life-threatening dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) occur. The pathophysiological hallmark of DHF and DSS is plasma leakage that leads to enhanced vascular permeability, likely due to a cytokine storm. METHODS:  Ninety patients with dengue during 2010-2012 in Singapore were prospectively recruited and stratified according to their disease phase, primary and secondary infection status, and disease severity, measured by plasma leakage...
January 1, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28076420/chaperone-mediated-autophagy-protein-bag3-negatively-regulates-ebola-and-marburg-vp40-mediated-egress
#3
Jingjing Liang, Cari A Sagum, Mark T Bedford, Sachdev S Sidhu, Marius Sudol, Ziying Han, Ronald N Harty
Ebola (EBOV) and Marburg (MARV) viruses are members of the Filoviridae family which cause outbreaks of hemorrhagic fever. The filovirus VP40 matrix protein is essential for virus assembly and budding, and its PPxY L-domain motif interacts with WW-domains of specific host proteins, such as Nedd4 and ITCH, to facilitate the late stage of virus-cell separation. To identify additional WW-domain-bearing host proteins that interact with VP40, we used an EBOV PPxY-containing peptide to screen an array of 115 mammalian WW-domain-bearing proteins...
January 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28065855/tyrosine-kinase-phosphatase-inhibitors-decrease-dengue-virus-production-in-hepg2-cells
#4
Thawornchai Limjindaporn, Jutatip Panaampon, Shilu Malakar, Sansanee Noisakran, Pathai Yenchitsomanus
Dengue virus is the causative agent of dengue fever, dengue hemorrhagic fever, and dengue shock syndrome. High rates of dengue virus replication and virion production are related to disease severity. To identify anti-DENV compounds, we performed cell-based ELISA testing to detect the level of DENV E protein expression. Among a total of 83 inhibitors, eight were identified as inhibitors with antiviral activity. Epidermal growth factor receptor inhibitor II (EGFR/ErbB-2/ErbB-4 inhibitor II) and protein tyrosine phosphatase inhibitor IV (PTP inhibitor IV) significantly inhibited dengue virus production and demonstrated low toxicity in hepatocyte cell lines...
January 5, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28053107/domain-organization-and-evolution-of-the-highly-divergent-5-coding-region-of-genomes-of-arteriviruses-including-the-novel-possum-nidovirus
#5
Anastasia Gulyaeva, Magdalena Dunowska, Erik Hoogendoorn, Julia Giles, Dmitry Samborskiy, Alexander E Gorbalenya
: In five experimentally characterized arterivirus species, the 5' -end genome coding region comprises most divergent nonstructural proteins (nsp) 1 and 2 that include papain-like proteases (PLPs) and other poorly characterized domains. They are involved in regulation of transcription, polyprotein processing, and virus-host interaction. Here, we present results of bioinformatics analysis of this region of 14 arterivirus species, including that of the most distantly related wobbly possum disease virus (WPDV), determined by a modified 5' RACE protocol...
January 4, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28051834/interferon-%C3%AE-induced-protein-10-in-dengue-virus-infection
#6
P Fallahi, G Elia
Dengue virus (DENV) infection causes dengue fever, dengue hemorrhagic fever, or dengue shock syndrome. Interferons (IFNs), and IFN-γ dependent chemokines, chemokine (C-X-C motif) ligand (CXCL)10/IFN-γ-induced protein 10 (IP-10), CXCL9/MIG and CXCL11/I-TAC, and their common receptor chemokine (C-X-C motif) receptor (CXCR)3 are induced by DENV infection; however it has been shown that the latter two could not compensate for the absence of IP-10. This paper reviews studies about DENV and IP-10. Evidences show the importance of IP-10 induction during DENV infection, in macrophages, lymphocytes, hepatic cells, denritic cells, in skin and in the brain...
November 2016: La Clinica Terapeutica
https://www.readbyqxmd.com/read/28051359/electron-microscopy-of-alkhumra-hemorrhagic-fever-virus
#7
Tariq A Madani, El-Tayb M E Abuelzein, Sawsan M Jalalah, Huda Abu-Araki, Esam I Azhar, Ahmed M Hassan, Hussein M S Al-Bar
Alkhumra hemorrhagic fever virus (AHFV) is a newly described zoonotic flavivirus that was first isolated during 1994-1995 from the Alkhumra district south of Jeddah, Saudi Arabia. Subsequently, the virus was also isolated from Makkah city (2001-2003) and Najran (2008-2009), Saudi Arabia. The virus causes acute febrile illness with hepatitis, hemorrhagic manifestations, and encephalitis. A case fatality rate of 25% was reported among hospitalized patients. Although several biological and molecular characteristics of the virus have been published, no data are available on electron microscopic features of the virus...
January 4, 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28033261/elevated-thrombopoietin-and-platelet-indices-confirm-active-thrombopoiesis-but-fail-to-predict-clinical-severity-of-puumala-hantavirus-infection
#8
Outi Laine, Lotta Joutsi-Korhonen, Riitta Lassila, Heini Huhtala, Antti Vaheri, Satu Mäkelä, Jukka Mustonen
We evaluated the mechanisms of thrombocytopenia and procoagulant changes in relation with clinical variables in a cohort of patients with acute hantavirus disease.Blood samples of 33 prospectively recruited, consecutive, hospitalized patients with acute Puumala virus-induced hemorrhagic fever with renal syndrome (HFRS) were collected acutely and at the recovery visit (control). Serum thrombopoietin (TPO) and activity of plasma microparticles (MPs) from various cell sources were measured with enzyme-linked immunosorbent assay-based methods...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28031723/economic-report-on-the-cost-of-dengue-fever-in-vietnam-case-of-a-provincial-hospital
#9
Luyen Dinh Pham, Nhat Huy Tran Phung, Nguyen Tu Dang Le, Trung Quang Vo
BACKGROUND: Dengue is a mosquito-borne viral illness with the world's fastest rate of infection. In 2014, Vietnam had recorded 43,000 cases in 53 provinces, with 28 deaths. MATERIALS AND METHODS: A 6-month cross-sectional study was conducted from September 2015 to March 2016 at Cu Chi General Hospital. Cost of illness in this study was estimated under the incidence-based approach from the societal perspective. RESULTS: The average cost per case was US$139...
2017: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/28031369/mapping-the-human-memory-b-cell-and-serum-neutralizing-antibody-responses-to-denv4-infection-and-vaccination
#10
Usha K Nivarthi, Nurgun Kose, Gopal Sapparapu, Douglas Widman, Emily Gallichotte, Jennifer M Pfaff, Benjamin J Doranz, Daniela Weiskopf, Alessandro Sette, Anna P Durbin, Steve S Whitehead, Ralph Baric, James E Crowe, Aravinda M de Silva
: The four dengue virus (DENV) serotypes are mosquito-borne flaviviruses responsible for dengue fever and dengue hemorrhagic fever. People exposed to DENV develop antibodies that strongly neutralize the serotype responsible for infection. Historically, infection with DENV serotype 4 (DENV4) has been less common and understudied in comparison to the other three serotypes. However, DENV4 has been responsible for recent large and sustained epidemics in Asia and Latin America. The neutralizing antibody responses and the epitopes targeted against DENV4 are not characterized in human infection...
December 28, 2016: Journal of Virology
https://www.readbyqxmd.com/read/28000060/a-new-strategy-for-full-length-ebola-virus-glycoprotein-expression-in-e-coli
#11
Junjie Zai, Yinhua Yi, Han Xia, Bo Zhang, Zhiming Yuan
Ebola virus (EBOV) causes severe hemorrhagic fever in humans and non-human primates with high rates of fatality. Glycoprotein (GP) is the only envelope protein of EBOV, which may play a critical role in virus attachment and entry as well as stimulating host protective immune responses. However, the lack of expression of full-length GP in Escherichia coli hinders the further study of its function in viral pathogenesis. In this study, the vp40 gene was fused to the full-length gp gene and cloned into a prokaryotic expression vector...
December 2016: Virologica Sinica
https://www.readbyqxmd.com/read/27999160/25-hydroxycholesterol-inhibition-of-lassa-virus-infection-through-aberrant-gp1-glycosylation
#12
Punya Shrivastava-Ranjan, Éric Bergeron, Ayan K Chakrabarti, César G Albariño, Mike Flint, Stuart T Nichol, Christina F Spiropoulou
: Lassa virus (LASV) infection is a major public health concern due to high fatality rates and limited effective treatment. The interferon-stimulated gene cholesterol 25-hydroxylase (CH25H) encodes an enzyme that catalyzes the production of 25-hydroxycholesterol (25HC). 25HC is involved in regulating cholesterol biosynthesis and has recently been identified as a potent antiviral targeting enveloped virus entry. Here, we show a previously unrecognized role of CH25H in inhibiting LASV glycoprotein glycosylation and the production of infectious virus...
December 20, 2016: MBio
https://www.readbyqxmd.com/read/27996292/activation-of-dengue-virus-specific-t-cells-modulates-vascular-endothelial-growth-factor-receptor-2-expression
#13
Jittraporn Rattanamahaphoom, Pornsawan Leaungwutiwong, Kriengsak Limkittikul, Nathamon Kosoltanapiwat, Anon Srikaitkhachorn
BACKGROUND: The pathogenic mechanisms underlying the increased vascular permeability in dengue hemorrhagic fever (DHF) are not well understood. Enhanced cellular immune activation, especially activation of serotype-cross reactive T cells, has been implicated in plasma leakage in DHF. Changes in several biological markers and mediators including cytokines, chemokines, angiogenic factors and their receptors have been shown to correlate with disease severity. A decline in plasma levels of a soluble form of vascular endothelial growth factor receptor 2 (VEGFR2), a receptor of vascular endothelial growth factor (VEGF), has been associated with plasma leakage in dengue patients...
December 12, 2016: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/27984785/comparison-of-n-and-o-linked-glycosylation-patterns-of-ebolavirus-glycoproteins
#14
Amanda L Collar, Elizabeth C Clarke, Eduardo Anaya, Denise Merrill, Sarah Yarborough, Scott M Anthony, Jens H Kuhn, Christine Merle, Manfred Theisen, Steven B Bradfute
Ebolaviruses are emerging pathogens that cause severe and often fatal viral hemorrhagic fevers. Four distinct ebolaviruses are known to cause Ebola virus disease in humans. The ebolavirus envelope glycoprotein (GP1,2) is heavily glycosylated, but the precise glycosylation patterns of ebolaviruses are largely unknown. Here we demonstrate that approximately 50 different N-glycan structures are present in GP1,2 derived from the four pathogenic ebolaviruses, including high mannose, hybrid, and bi-, tri-, and tetra-antennary complex glycans with and without fucose and sialic acid...
December 13, 2016: Virology
https://www.readbyqxmd.com/read/27981424/backbone-chemical-shift-assignments-and-secondary-structure-analysis-of-the-u1-protein-from-the-bas-congo-virus
#15
Garry W Buchko, Matthew C Clifton, Ellen G Wallace, Kateri A Atkins, Peter J Myler
The Bas-Congo virus (BASV) is the first rhabdovirus associated with a human outbreak of acute hemorrhagic fever. The single-stranded, negative-sense RNA genome of BASV contains the five core genes present in all rhabdoviral genomes plus an additional three genes, annotated U1, U2, and U3, with weak (<21%) sequence similarity only to a handful of genes observed in a few other rhabdoviral genomes. The function of the rhabdoviral U proteins is unknown, but, they are hypothesized to play a role in viral infection or replication...
December 15, 2016: Biomolecular NMR Assignments
https://www.readbyqxmd.com/read/27976688/a-hamster-model-for-marburg-virus-infection-accurately-recapitulates-marburg-hemorrhagic-fever
#16
Andrea Marzi, Logan Banadyga, Elaine Haddock, Tina Thomas, Kui Shen, Eva J Horne, Dana P Scott, Heinz Feldmann, Hideki Ebihara
Marburg virus (MARV), a close relative of Ebola virus, is the causative agent of a severe human disease known as Marburg hemorrhagic fever (MHF). No licensed vaccine or therapeutic exists to treat MHF, and MARV is therefore classified as a Tier 1 select agent and a category A bioterrorism agent. In order to develop countermeasures against this severe disease, animal models that accurately recapitulate human disease are required. Here we describe the development of a novel, uniformly lethal Syrian golden hamster model of MHF using a hamster-adapted MARV variant Angola...
December 15, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27974564/within-host-evolution-of-simian-arteriviruses-in-crab-eating-macaques
#17
Louise H Moncla, Andrea M Weiler, Gabrielle Barry, Jason T Weinfurter, Jorge M Dinis, Olivia Charlier, Michael Lauck, Adam L Bailey, Victoria Wahl-Jensen, Chase W Nelson, Joshua C Johnson, Yíngyún Caì, Tony L Goldberg, David H O'Connor, Peter B Jahrling, Jens H Kuhn, Thomas C Friedrich
: Simian arteriviruses are a diverse clade of viruses infecting captive and wild nonhuman primates. We recently reported that Kibale red colobus virus 1 (KRCV-1) causes a mild and self-limiting disease in experimentally infected crab-eating macaques, while simian hemorrhagic fever virus (SHFV) causes lethal viral hemorrhagic fever. Here we characterize how these viruses evolved during replication in cell culture and in experimentally infected macaques. During passage in cell culture, 68 substitutions became fixed in the KRCV-1 genome that were localized in open reading frames (ORFs) likely associated with host cell entry and exit...
December 14, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27959626/the-pathogenesis-of-ebola-virus-disease
#18
Laura Baseler, Daniel S Chertow, Karl M Johnson, Heinz Feldmann, David M Morens
For almost 50 years, ebolaviruses and related filoviruses have been repeatedly reemerging across the vast equatorial belt of the African continent to cause epidemics of highly fatal hemorrhagic fever. The 2013-2015 West African epidemic, by far the most geographically extensive, most fatal, and longest lasting epidemic in Ebola's history, presented an enormous international public health challenge, but it also provided insights into Ebola's pathogenesis and natural history, clinical expression, treatment, prevention, and control...
December 7, 2016: Annual Review of Pathology
https://www.readbyqxmd.com/read/27956656/transverse-myelitis-as-an-unusual-complication-of-dengue-fever
#19
Mânlio Tasso de Oliveira Mota, Cássia Fernanda Estofolete, Nathalia Zini, Ana Carolina Bernardes Terzian, Delzi Vinha Nunes Gongora, Irineu Luiz Maia, Maurício Lacerda Nogueira
Dengue fever is the most common arbovirus disease, and presents with a large spectrum of clinical manifestations ranging from asymptomatic disease through to the development of dengue hemorrhagic fever. These extreme cases can lead to dengue shock syndrome, and sometimes death. Spinal cord involvement in dengue virus (DENV) infections is rare. Here, we report a case in which the patient developed acute transverse myelitis (TM) without paraparesis following a DENV infection. This case highlights the importance of physicians' awareness of the possible link between DENV and TM in endemic areas...
December 12, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27943332/cytokine-response-to-hantaan-virus-infection-in-patients-with-hemorrhagic-fever-with-renal-syndrome
#20
Jing Guo, Xuli Guo, Yong Wang, Fang Tian, Weiguang Luo, Yizhou Zou
Hantaan virus (HTNV) infection of the human body causes a severe acute infectious disease known as hemorrhagic fever renal syndrome (HFRS). The aim of this study was to correlate patient cytokine profiles to HFRS severity. In this study, we discuss the clinical significance of evaluating HFRS treatment outcomes using cytokine information. The levels of 18 cytokines were quantitatively determined in three groups: 34 HTNV IgM+ cases, 63 HTNV IgM- negative cases, and 78 healthy volunteers. The level of 14 serum cytokines were higher in the patient group than that in the healthy control group...
December 12, 2016: Journal of Medical Virology
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