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JOURNAL ARTICLE
Shin Sato, Jyoji Yamate, Yuuka Hori, Asako Hatai, Megumi Nozawa, Masaru Sagai
This study was undertaken to investigate the effect of azuki bean (Vigna angularis) seed coats (ABSC), which contain polyphenols, on the infiltration of macrophages and the progression of diabetic nephropathy in streptozotocin (STZ)-induced diabetic rats. The diabetic rats were divided into three groups with 0% (commercial diet), 0.1% and 1.0% ABSC diets. The vehicle-injected controls were given a commercial diet. At 10 weeks, the macrophage kinetics, the degree of fibrosis in glomeruli and mRNA expression for monocyte chemoattractant protein-1 (MCP-1) were examined...
September 2005: Journal of Nutritional Biochemistry
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JOURNAL ARTICLE
Shin Sato, Yuuka Hori, Jyoji Yamate, Takeshi Saito, Masaaki Kurasaki, Asako Hatai
OBJECTIVE: We investigated the effects of azuki bean (Vigna angularis) seed coats (ABSCs), which mainly contain proanthocyanidins and dietary fibers, on the infiltration of macrophages and the progression of renal interstitial fibrosis induced by cisplatin (CDDP). METHODS: Male rats were divided into two groups: controls received intraperitoneal injections of saline and the other rats were injected intraperitoneally with 3 mg of CDDP per kilogram once a week for 5 wk...
April 2005: Nutrition
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