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Rose G Radin, Lindsey A Sjaarda, Neil J Perkins, Robert M Silver, Zhen Chen, Laurie L Lesher, Noya Galai, Jean Wactawski-Wende, Sunni L Mumford, Enrique F Schisterman
CONTEXT: Among women with a single, recent pregnancy loss, daily preconception low-dose aspirin (LDA) increased the live birth rate with no effect on pregnancy loss. The mechanism underlying this effect is unclear, but it may work through ovulation. OBJECTIVE: We estimated the effect of LDA on the per-cycle risk of anovulation among eumenorrheic women. DESIGN: The Effects of Aspirin in Gestation and Reproduction trial, a multi-center, randomized, double-blind, placebo-controlled trial of daily LDA on reproductive outcomes...
October 18, 2016: Journal of Clinical Endocrinology and Metabolism
G C Kabat, Wy-Y Wu, J W Bea, C Chen, L Qi, M L Stefanick, R T Chlebowski, D S Lane, J Wactawski-Wende, S Wassertheil-Smoller, T E Rohan
OBJECTIVE: The possibility that a subset of persons who are obese may be metabolically healthy-referred to as the 'metabolically healthy obese' (MHO) phenotype -- has attracted attention recently. However, few studies have followed individuals with MHO or other obesity phenotypes over time to assess change in their metabolic profiles. The aim of the present study was to examine transitions over a 6-year period among different states defined simultaneously by body mass index and presence/absence of the metabolic syndrome...
October 17, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
Peter T Campbell, Christina C Newton, Neal D Freedman, Jill Koshiol, Michael C Alavanja, Laura E Beane Freeman, Julie E Buring, Andrew T Chan, Dawn Q Chong, Mridul Datta, Mia M Gaudet, J Michael Gaziano, Edward L Giovannucci, Barry I Graubard, Albert R Hollenbeck, Lindsey King, I-Min Lee, Martha S Linet, Julie R Palmer, Jessica L Petrick, Jenny N Poynter, Mark P Purdue, Kim Robien, Lynn Rosenberg, Vikrant V Sahasrabuddhe, Catherine Schairer, Howard D Sesso, Alice J Sigurdson, Victoria L Stevens, Jean Wactawski-Wende, Anne Zeleniuch-Jacquotte, Andrew G Renehan, Katherine A McGlynn
Incidence rates for liver cancer have increased 3-fold since the mid-1970s in the United States in parallel with increasing trends for obesity and type II diabetes mellitus. We conducted an analysis of baseline body mass index (BMI), waist circumference (WC), and type II diabetes mellitus with risk of liver cancer. The Liver Cancer Pooling Project maintains harmonized data from 1.57 million adults enrolled in 14 U.S.-based prospective studies. Cox regression estimated HRs and 95% confidence intervals (CI) adjusted for age, sex, study center, alcohol, smoking, race, and BMI (for WC and type II diabetes mellitus)...
October 15, 2016: Cancer Research
Motti Ratmansky, Amir Minerbi, Leonid Kalichman, John Kent, Osnat Wende, Aharon S Finestone, Simon Vulfsons
OBJECTIVE: To develop consensus on a position paper on the use of intramuscular stimulation (IMS) for the treatment of myofascial pain syndrome (MPS) by physicians in Israel. METHODS: The Israeli Society of Musculoskeletal Medicine ran a modified Delphi process to gather opinions from a multidisciplinary expert panel. Eight experts in the treatment of MPS were chosen and asked to participate, and six participated. The position paper was iterated three times. RESULTS: After three iterations, general consensus was reached by all six experts...
October 14, 2016: Pain Practice: the Official Journal of World Institute of Pain
Simone Marocchi, Andrea Candini, David Klar, Willem Van den Heuvel, Haibei Huang, Filippo Troiani, Valdis Corradini, Roberto Biagi, Valentina De Renzi, Svetlana Klyatskaya, Kurt Kummer, Nicholas B Brookes, Mario Ruben, Heiko Wende, Umberto Del Pennino, Alessandro Soncini, Marco Affronte, Valerio Bellini
We investigate the electronic and magnetic properties of \ce{TbPc2} single ion magnets adsorbed on a graphene/Ni(111) substrate, by density-functional theory (DFT), ab-initio complete active space self-consistent field calculations, and x-ray magnetic circular dichroism (XMCD) experiments. Despite the presence of the graphene decoupling layer a sizable antiferromagnetic coupling between Tb and Ni is observed in the XMCD experiments. The molecule-surface interaction is rationalized by the DFT analysis and is found to follow a relay-like communication pathway, where the radical spin on the organic Pc ligands mediates the interaction between Tb ion and Ni substrate spins...
October 11, 2016: ACS Nano
Mert Yanik, Brigitte Müller, Fei Song, Jacqueline Gall, Franziska Wagner, Wolfgang Wende, Birgit Lorenz, Knut Stieger
In vivo genome editing represents an emerging field in the treatment of monogenic disorders, as it may constitute a solution to the current hurdles in classic gene addition therapy, which are the low levels and limited duration of transgene expression. Following the introduction of a double strand break (DSB) at the mutational site by highly specific endonucleases, such as TALENs (transcription activator like effector nucleases) or RNA based nucleases (clustered regulatory interspaced short palindromic repeats - CRISPR-Cas), the cell's own DNA repair machinery restores integrity to the DNA strand and corrects the mutant sequence, thus allowing the cell to produce protein levels as needed...
September 10, 2016: Progress in Retinal and Eye Research
Mingfeng Zhang, Zhaoming Wang, Ofure Obazee, Jinping Jia, Erica J Childs, Jason Hoskins, Gisella Figlioli, Evelina Mocci, Irene Collins, Charles C Chung, Christopher Hautman, Alan A Arslan, Laura Beane-Freeman, Paige M Bracci, Julie Buring, Eric J Duell, Steven Gallinger, Graham G Giles, Gary E Goodman, Phyllis J Goodman, Aruna Kamineni, Laurence N Kolonel, Matthew H Kulke, Núria Malats, Sara H Olson, Howard D Sesso, Kala Visvanathan, Emily White, Wei Zheng, Christian C Abnet, Demetrius Albanes, Gabriella Andreotti, Lauren Brais, H Bas Bueno-de-Mesquita, Daniela Basso, Sonja I Berndt, Marie-Christine Boutron-Ruault, Maarten F Bijlsma, Hermann Brenner, Laurie Burdette, Daniele Campa, Neil E Caporaso, Gabriele Capurso, Giulia Martina Cavestro, Michelle Cotterchio, Eithne Costello, Joanne Elena, Ugo Boggi, J Michael Gaziano, Maria Gazouli, Edward L Giovannucci, Michael Goggins, Myron Gross, Christopher A Haiman, Manal Hassan, Kathy J Helzlsouer, Nan Hu, David J Hunter, Elzbieta Iskierka-Jazdzewska, Mazda Jenab, Rudolf Kaaks, Timothy J Key, Kay-Tee Khaw, Eric A Klein, Manolis Kogevinas, Vittorio Krogh, Juozas Kupcinskas, Robert C Kurtz, Maria T Landi, Stefano Landi, Loic Le Marchand, Andrea Mambrini, Satu Mannisto, Roger L Milne, Rachel E Neale, Ann L Oberg, Salvatore Panico, Alpa V Patel, Petra H M Peeters, Ulrike Peters, Raffaele Pezzilli, Miquel Porta, Mark Purdue, J Ramón Quiros, Elio Riboli, Nathaniel Rothman, Aldo Scarpa, Ghislaine Scelo, Xiao-Ou Shu, Debra T Silverman, Pavel Soucek, Oliver Strobel, Malin Sund, Ewa Małecka-Panas, Philip R Taylor, Francesca Tavano, Ruth C Travis, Mark Thornquist, Anne Tjønneland, Geoffrey S Tobias, Dimitrios Trichopoulos, Yogesh Vashist, Pavel Vodicka, Jean Wactawski-Wende, Nicolas Wentzensen, Herbert Yu, Kai Yu, Anne Zeleniuch-Jacquotte, Charles Kooperberg, Harvey A Risch, Eric J Jacobs, Donghui Li, Charles Fuchs, Robert Hoover, Patricia Hartge, Stephen J Chanock, Gloria M Petersen, Rachael S Stolzenberg-Solomon, Brian M Wolpin, Peter Kraft, Alison P Klein, Federico Canzian, Laufey T Amundadottir
Genome-wide association studies (GWAS) have identified common pancreatic cancer susceptibility variants at 13 chromosomal loci in individuals of European descent. To identify new susceptibility variants, we performed imputation based on 1000 Genomes (1000G) Project data and association analysis using 5,107 case and 8,845 control subjects from 27 cohort and case-control studies that participated in the PanScan I-III GWAS. This analysis, in combination with a two-staged replication in an additional 6,076 case and 7,555 control subjects from the PANcreatic Disease ReseArch (PANDoRA) and Pancreatic Cancer Case-Control (PanC4) Consortia uncovered 3 new pancreatic cancer risk signals marked by single nucleotide polymorphisms (SNPs) rs2816938 at chromosome 1q32...
August 1, 2016: Oncotarget
Dan Zhu, Houxiang Kang, Zhiqiang Li, Minghao Liu, Xiaoli Zhu, Yue Wang, Dan Wang, Zhilong Wang, Wende Liu, Guo-Liang Wang
BACKGROUND: Breeding of rice cultivars with long-lasting resistance to the rice blast fungus Magnaporthe oryzae is difficult, and identification of new resistance genes is essential. Most of the loci associated with blast resistance against M. oryzae in rice have been identified in controlled environments and with single isolates, and such loci may confer resistance to only a small faction of the M. oryzae strains. In the field, however, rice is commonly attacked by multiple strains. Research is therefore needed to identify loci that confer resistance in the field, i...
December 2016: Rice
Anna Z Pollack, Neil J Perkins, Lindsey Sjaarda, Sunni L Mumford, Kurunthachalam Kannan, Claire Philippat, Jean Wactawski-Wende, Enrique F Schisterman
BACKGROUND: Human exposure to phenols and parabens is widespread. Within-person variability of urinary concentrations in healthy women is not well characterized. OBJECTIVES: To characterize the variability of urinary phenol and paraben concentrations across two months and evaluate the ability of a single spot urine sample to characterize exposure. METHODS: 143 women provided 509 spot urine samples collected across two months of study (3-5 samples/woman)...
August 24, 2016: Environmental Research
Jane A Cauley, Stephen F Smagula, Kathleen M Hovey, Jean Wactawski-Wende, Christopher A Andrews, Carolyn J Crandall, Meryl S LeBoff, Wenjun Li, Mace Coday, Maryam Sattari, Hilary A Tindle
Traits of optimism and cynical hostility are features of personality that could influence the risk of falls and fractures by influencing risk taking behaviors, health behaviors or inflammation. To test the hypothesis that personality influences falls and fracture risk, we studied 87,342 women enrolled in WHI-OS. Optimism was assessed by the Life Orientation Test - Revised and cynical hostility, the cynicism subscale of the Cook-Medley questionnaire. Higher scores indicate greater optimism and hostility. Optimism and hostility were correlated at r = -0...
August 27, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Kun Song, Hong Wang, Gretel B Kamm, Jörg Pohle, Fernanda de Castro Reis, Paul Heppenstall, Hagen Wende, Jan Siemens
Body temperature homeostasis is critical for survival and requires precise regulation by the nervous system. The hypothalamus serves as the principal thermostat that detects and regulates internal temperature. We demonstrate that the ion channel TRPM2 [of the transient receptor potential (TRP) channel family] is a temperature sensor in a subpopulation of hypothalamic neurons. TRPM2 limits the fever response and may detect increased temperatures to prevent overheating. Furthermore, chemogenetic activation and inhibition of hypothalamic TRPM2-expressing neurons in vivo decreased and increased body temperature, respectively...
September 23, 2016: Science
Wending Zhang, Keyan Wei, Ligang Huang, Dong Mao, Biqiang Jiang, Feng Gao, Guoquan Zhang, Ting Mei, Jianlin Zhao
We presented a method to actualize the optical vortex generation with wavelength tunability via an acoustically-induced fiber grating (AIFG) driven by a radio frequency source. The circular polarization fundamental mode could be converted to the first-order optical vortex through the AIFG, and its topological charges were verified by the spiral pattern of coaxial interference between the first-order optical vortex and a Gaussian-reference beam. A spectral tuning range from 1540 nm to 1560 nm was demonstrated with a wavelength tunability slope of 4...
August 22, 2016: Optics Express
M Naveed-Ul-Haq, Vladimir V Shvartsman, Soma Salamon, Heiko Wende, Harsh Trivedi, Arif Mumtaz, Doru C Lupascu
The lead-free ferroelectric 0.5Ba(Zr0.2Ti0.8)O3 - 0.5(Ba0.7Ca0.3)TiO3 (BCZT) is a promising component for multifunctional multiferroics due to its excellent room temperature piezoelectric properties. Having a composition close to the polymorphic phase boundary between the orthorhombic and tetragonal phases, it deserves a case study for analysis of its potential for modern electronics applications. To obtain magnetoelectric coupling, the piezoelectric phase needs to be combined with a suitable magnetostrictive phase...
2016: Scientific Reports
Georgios Athanasiadis, Jade Y Cheng, Bjarni J Vilhjálmsson, Frank G Jørgensen, Thomas D Als, Stephanie Le Hellard, Thomas Espeseth, Patrick F Sullivan, Christina M Hultman, Peter C Kjærgaard, Mikkel H Schierup, Thomas Mailund
Denmark has played a substantial role in the history of Northern Europe. Through a nationwide scientific outreach initiative, we collected genetic and anthropometrical data from ∼800 high school students and used them to elucidate the genetic makeup of the Danish population, as well as to assess polygenic predictions of phenotypic traits in adolescents. We observed remarkable homogeneity across different geographic regions, although we could still detect weak signals of genetic structure reflecting the history of the country...
October 2016: Genetics
Theodore M Brasky, Emily White, Jean Wactawski-Wende
No abstract text is available yet for this article.
October 1, 2016: JAMA Oncology
Rui Xiao, Xuhui Zhang, Zhen Rong, Bingshui Xiu, Xiqin Yang, Chongwen Wang, Wende Hao, Qi Zhang, Zhiqiang Liu, Cuimi Duan, Kai Zhao, Xu Guo, Yawen Fan, Yanfeng Zhao, Heather Johnson, Yan Huang, Xiaoyan Feng, Xiaohong Xu, Heqiu Zhang, Shengqi Wang
The present study aims to identify distinctive Raman spectrum metabolic peaks to predict hepatocellular carcinoma (HCC). We performed a label-free, non-invasive surface-enhanced Raman spectroscopy (SERS) test on 230 serum samples including 47 HCC, 60 normal controls (NC), 68 breast cancer (BC) and 55 lung cancer (LC) by mixing Au@AgNRs with serum directly. Based on the observed SERS spectra, discriminative metabolites including tryptophan, phenylalanine, and etc. were found in HCC, when compared with BC, LC, and NC (P<0...
August 9, 2016: Nanomedicine: Nanotechnology, Biology, and Medicine
Anke Schmidt, Sander Bekeschus, Kristian Wende, Brigitte Vollmar, Thomas von Woedtke
Cold plasma has been successfully applied in several fields of medicine that require, e.g. pathogen inactivation, implant functionalization, or alteration of cellular activity. Previous studies have provided evidence that plasma supports the healing of wounds owing to its beneficial mixtures of reactive species and modulation of inflammation in cells and tissues. To investigate the wound-healing activity of an atmospheric pressure plasma jet in vivo, we examined the cold plasma's efficacy on dermal regeneration in a murine model of dermal full-thickness ear-wound...
August 5, 2016: Experimental Dermatology
Kefeng Wu, Xiang Gao, Baoyan Shi, Shiyu Chen, Xin Zhou, Zhidong Li, Yuhong Gan, Liao Cui, Jing Xuan Kang, Wende Li, Ren Huang
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that accompanied by memory deficits and neuropsychiatric dysfunction. Omega-3 polyunsaturated fatty acids (n-3 PUFAs) have seemly therapeutic potential in AD, but the benefit of n-3 PUFAs is still in debates. Here, we employed a transgenic mice carry fat-1 gene to encode n-3 desaturase from Caenorhabditis elegans, which increase endogenous n-3 PUFAs by converting n-6 PUFAs to n-3 PUFAs crossed with amyloid precursor protein (APP) Tg mice to evaluate the protective effects of endogenous n-3 PUFAs on cognitive and behavioral deficits of APP Tg mice...
October 1, 2016: Neuroscience
Wei Li, Xiaoxu Zhao, Bin Du, Xin Li, Shuhao Liu, Xiao-Yan Yang, Hui Ding, Wende Yang, Fan Pan, Xiaobo Wu, Li Qin, Yunlong Pan
Tumour vasculature is generally disordered because of the production of excessive angiogenic factors by tumour cells, which results in tumour progression and reduces the effectiveness of radiotherapy or chemotherapy. Transient anti-angiogenic therapies that regulate tumour vascular morphology and function and improve the efficiency of antitumour therapy are under investigation. Recombinant human endostatin (Endostar/rhES) is a vascular angiogenesis-disrupting agent that has been used to treat non-small cell lung cancer (NSCLC) in the clinical setting...
2016: Scientific Reports
Ange Wang, FeiFei Qin, Haley Hedlin, Manisha Desai, Rowan Chlebowski, Scarlett Gomez, Charles B Eaton, Karen C Johnson, Lihong Qi, Jean Wactawski-Wende, Catherine Womack, Heather A Wakelee, Marcia L Stefanick
Physical activity has been associated with lower lung cancer incidence and mortality in several populations. We investigated these relationships in the Women's Health Initiative Observational Study (WHI-OS) and Clinical Trial (WHI-CT) prospective cohort of postmenopausal women. The WHI study enrolled 161,808 women aged 50-79 years between 1993 and 1998 at 40 U.S. clinical centers; 129,401 were eligible for these analyses. Cox proportional hazards models were used to assess the association of baseline physical activity levels [metabolic equivalent (MET)-min/week: none <100 (reference), low 100 to <500, medium 500 to <1,200, high 1,200+] and sedentary behavior with total lung cancer incidence and mortality...
November 15, 2016: International Journal of Cancer. Journal International du Cancer
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