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https://www.readbyqxmd.com/read/28231077/association-of-genetic-variation-in-the-tachykinin-receptor-3-locus-with-hot-flashes-and-night-sweats-in-the-women-s-health-initiative-study
#1
Carolyn J Crandall, JoAnn E Manson, Chancellor Hohensee, Steve Horvath, Jean Wactawski-Wende, Erin S LeBlanc, Mara Z Vitolins, Rami Nassir, Janet S Sinsheimer
OBJECTIVE: Vasomotor symptoms (VMS, ie, hot flashes or night sweats) are reported by many, but not all, women. The extent to which VMS are genetically determined is unknown. We evaluated the relationship of genetic variation and VMS. METHODS: In this observational study, we accessed data from three genome-wide association studies (GWAS) (SNP Health Association Resource cohort [SHARe], WHI Memory Study cohort [WHIMS+], and Genome-Wide Association Studies of Treatment Response in Randomized Clinical Trials [GARNET] studies, total n = 17,695) of European American, African American, and Hispanic American postmenopausal women aged 50 to 79 years at baseline in the Women's Health Initiative Study...
March 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28176488/association-between-nighttime-sleep-duration-sleep-timing-and-falls-among-middle-aged-and-older-chinese-population-a-cross-sectional-analysis-from-the-dongfeng-tongji-cohort-study-china
#2
Yi Wang, Wending Li, Lijun Shen, Lulu Song, Hui Li, Bingqing Liu, Jing Yuan, Youjie Wang
AIM: To examine the association between nighttime sleep duration, sleep timing, and their interactive effect on falls among middle-aged and older Chinese adults. METHODS: The study sample of 35,465 (mean age 64.5 years) subjects were from the Dongfeng-Tongji cohort. All subjects completed baseline questionnaires and medical examinations. Participants were classified into five groups based on nighttime sleep duration: <7 h, 7- ≤ 8 h, 8- ≤ 9 h, 9- ≤ 10 h, ≥10 h, and three groups based on sleep timing: <21:00, 21:00- ≤ 23:00, ≥23:00...
February 8, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28165909/intentional-weight-loss-and-endometrial-cancer-risk
#3
Juhua Luo, Rowan T Chlebowski, Michael Hendryx, Thomas Rohan, Jean Wactawski-Wende, Cynthia A Thomson, Ashley S Felix, Chu Chen, Wendy Barrington, Mace Coday, Marcia Stefanick, Erin LeBlanc, Karen L Margolis
Purpose Although obesity is an established endometrial cancer risk factor, information about the influence of weight loss on endometrial cancer risk in postmenopausal women is limited. Therefore, we evaluated associations among weight change by intentionality with endometrial cancer in the Women's Health Initiative (WHI) observational study. Patients and Methods Postmenopausal women (N = 36,794) ages 50 to 79 years at WHI enrollment had their body weights measured and body mass indices calculated at baseline and at year 3...
February 6, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28157938/investigation-of-magneto-induced-linear-dichroism-of-magnetic-fluid
#4
Bobo Du, Dexing Yang, Yang Bai, Yuan Yuan, Dong Mao, Wending Zhang, Xiaoyang She
A fiber-optic component is fabricated with etched fiber coated by magnetic fluid (MF) for its evanescent field to be modulated by the MF. The magneto-induced linear dichroism of the MF is investigated under different temperatures with the component. The experimental results show that the MF possesses weak linear dichroism (maximum of 2.37% at 25°C) caused by its sparse magneto-induced chains. Considering the relationships between the linear dichroisms and temperature, there is a transition point of magnetic field at ∼4  mT...
January 20, 2017: Applied Optics
https://www.readbyqxmd.com/read/28148500/the-influence-of-genetic-susceptibility-and-calcium-plus-vitamin-d-supplementation-on-fracture-risk
#5
Youjin Wang, Jean Wactawski-Wende, Lara E Sucheston-Campbell, Leah Preus, Kathleen M Hovey, Jing Nie, Rebecca D Jackson, Samuel K Handelman, Rami Nassir, Carolyn J Crandall, Heather M Ochs-Balcom
BACKGROUND: Fracture is a complex trait, affected by both genetic and environmental factors. A meta-analysis of genome-wide association studies (GWASs) identified multiple bone mineral density (BMD) and fracture-associated loci. OBJECTIVE: We conducted a study to evaluate whether fracture genetic risk score (Fx-GRS) and bone mineral density genetic risk score (BMD-GRS) modify the association between the intake of calcium with vitamin D (CaD) and fracture risk. DESIGN: Data from 5823 white postmenopausal women from the Women's Health Initiative CaD randomized trial were included...
February 1, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28146500/generation-of-femtosecond-optical-vortex-pulse-in-fiber-based-on-an-acoustically-induced-fiber-grating
#6
Wending Zhang, Keyan Wei, Dong Mao, Heng Wang, Feng Gao, Ligang Huang, Ting Mei, Jianlin Zhao
We proposed a method for generation of a femtosecond optical vortex pulse in a two-mode fiber based on an acoustically induced fiber grating (AIFG) driven by a radio frequency source. Theoretical analysis and experimental results demonstrated that the left- and right-handed circular polarization fundamental modes of the femtosecond optical pulse could be converted to the linearly polarized ±1-order optical vortex modes through the AIFG with the mode conversion efficiency of ∼95%. The off-axial interference experiment and the polarization angle-dependent intensity examination were performed to verify the topological charge and the polarization state of the femtosecond optical vortex, respectively...
February 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28114701/-genome-editing-tools-and-their-application-in-experimental-ophthalmology
#7
M Yanik, W Wende, K Stieger
New genome editing tools in molecular biology are revolutionising precise genome surgery and have greatly influenced experimental ophthalmology too. Aside from the commonly used nuclease-based platforms, such as the zinc-finger nucleases (ZFN) and transcription activator-like effector nucleases (TALEN), CRISPR/Cas systems, clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) genes, perform very efficiently in site-specific DNA cleavage within living cells. DNA double strand breaks (DSB) are repaired through two different conserved repair pathways: NHEJ (non-homologous end joining) and HDR (homology directed repair)...
January 23, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28074862/hypoxia-activates-wnt-%C3%AE-catenin-signaling-by-regulating-the-expression-of-bcl9-in-human-hepatocellular-carcinoma
#8
Wei Xu, Wang Zhou, Mo Cheng, Jing Wang, Zhian Liu, Shaohui He, Xiangji Luo, Wending Huang, Tianrui Chen, Wangjun Yan, Jianru Xiao
The Wnt/β-catenin signaling is abnormally activated in the progression of hepatocellular carcinoma (HCC). BCL9 is an essential co-activator in the Wnt/β-catenin signaling. Importantly, BCL9 is absent from tumors originating from normal cellular counterparts and overexpressed in many cancers including HCC. But the mechanism for BCL9 overexpression remains unknown. Ample evidence indicates that hypoxia inducible factors (HIFs) play a role in the development of HCC. It was found in our study that BCL9 was overexpressed in both primary HCC and bone metastasis specimens; loss of BCL9 inhibited the proliferation, migration and angiogenesis of HCC; and that that hypoxia mechanically induced the expression of BCL9...
January 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28039445/aromatase-inhibitor-induced-bone-loss-increases-the-progression-of-estrogen-receptor-negative-breast-cancer-in-bone-and-exacerbates-muscle-weakness-in-vivo
#9
Laura E Wright, Ahmed A Harhash, Wende M Kozlow, David L Waning, Jenna N Regan, Yun She, Sutha K John, Sreemala Murthy, Maryla Niewolna, Andrew R Marks, Khalid S Mohammad, Theresa A Guise
Aromatase inhibitors (AIs) cause muscle weakness, bone loss, and joint pain in up to half of cancer patients. Preclinical studies have demonstrated that increased osteoclastic bone resorption can impair muscle contractility and prime the bone microenvironment to accelerate metastatic growth. We hypothesized that AI-induced bone loss could increase breast cancer progression in bone and exacerbate muscle weakness associated with bone metastases. Female athymic nude mice underwent ovariectomy (OVX) or sham surgery and were treated with vehicle or AI (letrozole; Let)...
January 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/28019686/dietary-inflammatory-index-bone-mineral-density-and-risk-of-fracture-in-postmenopausal-women-results-from-the-women-s-health-initiative
#10
Tonya Orchard, Vedat Yildiz, Susan E Steck, James R Hébert, Yunsheng Ma, Jane A Cauley, Wenjun Li, Yasmin Mossavar-Rahmani, Karen C Johnson, Maryam Sattari, Meryl LeBoff, Jean Wactawski-Wende, Rebecca D Jackson
Previous studies suggest that bone loss and fracture risk are associated with higher inflammatory milieu, potentially modifiable by diet. The primary objective of this analysis was to evaluate the association of the dietary inflammatory index (DII(TM) ), a measure of the inflammatory potential of diet, with risk of hip, lower-arm and total fracture using longitudinal data from the Women's Health Initiative Observational Study and Clinical Trials. Secondarily, we evaluated changes in bone mineral density (BMD) and DII scores...
December 26, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28007567/global-phylogeography-of-oithona-similis-s-l-crustacea-copepoda-oithonidae-a-cosmopolitan-plankton-species-or-a-complex-of-cryptic-lineages
#11
Astrid Cornils, Britta Wend-Heckmann, Christoph Held
Traditionally, many small-sized copepod species are considered to be widespread, bipolar or cosmopolitan. However, these large-scale distribution patterns need to be re-examined in view of increasing evidence of cryptic and pseudo-cryptic speciation in pelagic copepods. Here, we present a phylogeographic study of Oithona similis s.l. populations from the Arctic Ocean, the Southern Ocean and its northern boundaries, the North Atlantic and the Mediterrranean Sea. O. similis s.l. is considered as one of the most abundant species in temperate to polar oceans and acts as an important link in the trophic network between the microbial loop and higher trophic levels such as fish larvae...
December 19, 2016: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/27989460/touch-receptor-derived-sensory-information-alleviates-acute-pain-signaling-and-fine-tunes-nociceptive-reflex-coordination
#12
Alice Arcourt, Louise Gorham, Rahul Dhandapani, Vincenzo Prato, Francisco J Taberner, Hagen Wende, Vijayan Gangadharan, Carmen Birchmeier, Paul A Heppenstall, Stefan G Lechner
Painful mechanical stimuli activate multiple peripheral sensory afferent subtypes simultaneously, including nociceptors and low-threshold mechanoreceptors (LTMRs). Using an optogenetic approach, we demonstrate that LTMRs do not solely serve as touch receptors but also play an important role in acute pain signaling. We show that selective activation of neuropeptide Y receptor-2-expressing (Npy2r) myelinated A-fiber nociceptors evokes abnormally exacerbated pain, which is alleviated by concurrent activation of LTMRs in a frequency-dependent manner...
January 4, 2017: Neuron
https://www.readbyqxmd.com/read/27987864/1d-nmr-methods-for-determination-of-degree-of-cross-linking-and-bdde-substitution-positions-in-ha-hydrogels
#13
Frida J Wende, Suresh Gohil, Lars I Nord, Anne Helander Kenne, Corine Sandström
Hyaluronic acid polymers cross-linked with BDDE are today among the most used hydrogels for biomedical applications. The physical properties of the hydrogels depend, among other parameters, on the degree of cross-linking of HA. Another parameter likely to affect the physical properties is the substitution position of the linker on the HA functional groups. A NMR-based method for the determination of these parameters in hyaluronic acid hydrogels is presented. The method is based on the degradation of HA cross linked hydrogels by chondroitinase ABC followed by one-dimensional (1)H and (13)C NMR analysis...
February 10, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27965573/7-8-dihydroxyflavone-ameliorates-cognitive-impairment-by-inhibiting-expression-of-tau-pathology-in-apoe-knockout-mice
#14
Yang Tan, Shuke Nie, Wende Zhu, Fang Liu, Hailong Guo, Jiewen Chu, Xue B Cao, Xingjun Jiang, Yunjian Zhang, Yuzhen Li
7,8-Dihydroxyflavone (7,8-DHF), a tyrosine kinase B agonist that mimics the neuroprotective properties of brain-derived neurotrophic factor, which can not efficiently deliver into the brain, has been reported to be useful in ameliorating cognitive impairment in many diseases. Researches have indicated that apolipoprotein E-knockout (ApoE-KO) mouse was associated with cognitive alteration via various mechanisms. Our present study investigated the possible mechanisms of cognitive impairment of ApoE-KO mouse fed with western type diet and the protective effects of 7,8-DHF in improving spatial learning and memory in ApoE-KO mouse...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27934055/sub-10-fs-time-resolved-vibronic-optical-microscopy
#15
Christoph Schnedermann, Jong Min Lim, Torsten Wende, Alex S Duarte, Limeng Ni, Qifei Gu, Aditya Sadhanala, Akshay Rao, Philipp Kukura
We introduce femtosecond wide-field transient absorption microscopy combining sub-10 fs pump and probe pulses covering the complete visible (500-650 nm) and near-infrared (650-950 nm) spectrum with diffraction-limited optical resolution. We demonstrate the capabilities of our system by reporting the spatially- and spectrally-resolved transient electronic response of MAPbI3-xClx perovskite films and reveal significant quenching of the transient bleach signal at grain boundaries. The unprecedented temporal resolution enables us to directly observe the formation of band-gap renormalization, completed in 25 fs after photoexcitation...
December 1, 2016: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/27932054/changes-in-physical-activity-sedentary-time-and-risk-of-falling-the-women-s-health-initiative-observational-study
#16
Jennifer W Bea, Cynthia A Thomson, Robert B Wallace, Chunyuan Wu, Rebecca A Seguin, Scott B Going, Andrea LaCroix, Charles Eaton, Judith K Ockene, Michael J LaMonte, Rebecca Jackson, W Jerry Mysiw, Jean Wactawski-Wende
Falling significantly affects quality of life, morbidity, and mortality among older adults. We sought to evaluate the prospective association between sedentary time, physical activity, and falling among post-menopausal women aged 50-79years recruited to the Women's Health Initiative Observational Study between 1993 and 1998 from 40 clinical centers across the United States. Baseline (B) and change in each of the following were evaluated at year 3 (Y3) and year 6 (Y6; baseline n=93,676; Y3 n=76,598; Y6 n=75,428): recreational physical activity (MET-h/wk), sitting, sleeping (min/day), and lean body mass by dual energy X-ray absorptiometry (subset N=6475)...
February 2017: Preventive Medicine
https://www.readbyqxmd.com/read/27900430/visible-and-red-emissive-molecular-beacons-for-optical-temperature-measurements-and-quality-control-in-diagnostic-assays-utilizing-temperature-dependent-amplification-reactions
#17
Zerrin Fidan, Andy Wende, Ute Resch-Genger
Quality control requirements imposed on assays used in clinical diagnostics and point-of-care-diagnostic testing (POCT), utilizing amplification reactions performed at elevated temperatures of 35 to 95 °C are very stringent. As the temperature of a reaction vessel has a large impact on the specificity and sensitivity of the amplification reaction, simple tools for local in situ temperature sensing and monitoring are required for reaction and assay control. We describe here a platform of stem-and-loop structured DNA hairpins (molecular beacons, MBs), absorbing and emitting in the visible and red spectral region, rationally designed for precise temperature measurements in microfluidic assays for POCT, and their application for temperature measurements in a common DNA-based molecular biological assay utilizing thermophilic helicase-dependent amplification (tHDA)...
November 29, 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27881593/dairy-food-intake-is-associated-with-reproductive-hormones-and-sporadic-anovulation-among-healthy-premenopausal-women
#18
Keewan Kim, Jean Wactawski-Wende, Kara A Michels, Torie C Plowden, Ellen N Chaljub, Lindsey A Sjaarda, Sunni L Mumford
BACKGROUND: Dairy food intake has been associated with infertility; however, little is known with regard to associations with reproductive hormones or anovulation. OBJECTIVE: We investigated whether intakes of dairy foods and specific nutrients were associated with reproductive hormone concentrations across the cycle and the risk of sporadic anovulation among healthy women. METHODS: We prospectively measured serum reproductive hormones ≤8 times/menstrual cycle for 2 cycles from 259 regularly menstruating women (mean age: 27...
February 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/27879043/uncovering-key-structural-features-of-an-enantioselective-peptide-catalyzed-acylation-utilizing-advanced-nmr-techniques
#19
Eliška Procházková, Andreas Kolmer, Julian Ilgen, Mira Schwab, Lukas Kaltschnee, Maic Fredersdorf, Volker Schmidts, Raffael C Wende, Peter R Schreiner, Christina M Thiele
We report on a detailed NMR spectroscopic study of the catalyst-substrate interaction of a highly enantioselective oligopeptide catalyst that is used for the kinetic resolution of trans-cycloalkane-1,2-diols via monoacylation. The extraordinary selectivity has been rationalized by molecular dynamics as well as density functional theory (DFT) computations. Herein we describe the conformational analysis of the organocatalyst studied by a combination of nuclear Overhauser effect (NOE) and residual dipolar coupling (RDC)-based methods that resulted in an ensemble of four final conformers...
December 19, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27872138/micrornas-103-107-coordinately-regulate-macropinocytosis-and-autophagy
#20
Jong Kook Park, Han Peng, Julia Katsnelson, Wending Yang, Nihal Kaplan, Ying Dong, Joshua Z Rappoport, CongCong He, Robert M Lavker
Macropinocytosis, by which cells ingest large amounts of fluid, and autophagy, the lysosome-based catabolic process, involve vesicular biogenesis (early stage) and turnover (end stage). Much is known about early-stage events; however, our understanding of how the end stages of these processes are governed is incomplete. Here we demonstrate that the microRNA-103/107(miR-103/107) family, which is preferentially expressed in the stem cell-enriched limbal epithelium, coordinately regulates aspects of both these activities...
December 5, 2016: Journal of Cell Biology
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