keyword
https://read.qxmd.com/read/38529946/patterns-of-sleep-duration-and-metabolic-biomarkers-across-the-menstrual-cycle
#1
JOURNAL ARTICLE
Galit Levi Dunietz, Kerby Shedden, Xiru Lyu, Ronald D Chervin, Ana Baylin, Louise M O'Brien, Erica C Jansen, Jean Wactawski-Wende, Enrique F Schisterman, Sunni L Mumford
CONTEXT: Along the menstrual cycle, associations between inconsistent sleep duration and levels of metabolic biomarkers are uncertain and could involve fluctuations in estrogen concentrations. OBJECTIVE: To examine associations between patterns of sleep duration and metabolic biomarkers across two menstrual cycles within a cohort of premenopausal women. METHODS: The BioCycle Study was conducted in New York between 2005-2007, enrolling 259 premenopausal women over two menstrual cycles...
March 26, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38529607/gene-therapy-for-skin-aging
#2
JOURNAL ARTICLE
Fawzy A Saad
Extrinsic and intrinsic factors contribute to skin aging; nonetheless, they are intertwined. Moreover, intrinsic skin aging mirrors age-related declines in the entire human body's internal organs. There is evidence that skin appearance is an indicator of the general health of somebody. Earlier, it was apparent that the intrinsic factors are unalterable, but the sparkling of skin aging gene therapy on the horizon is changing this narrative. Skin aging gene therapy offers tools for skin rejuvenation and, natural beauty restoration, and therapy for diseases affecting the entire skin...
March 25, 2024: Current Gene Therapy
https://read.qxmd.com/read/38524357/implementation-of-a-prehospital-whole-blood-program-lessons-learned
#3
JOURNAL ARTICLE
Matthew J Levy, Eric M Garfinkel, Robert May, Eric Cohn, Zachary Tillett, Christopher Wend, Robert A Sikorksi, Ruben Troncoso, J Lee Jenkins, Timothy P Chizmar, Asa M Margolis
Early blood administration by Emergency Medical Services (EMS) to patients suffering from hemorrhagic shock improves outcomes. Prehospital blood programs represent an invaluable resuscitation capability that directly addresses hemorrhagic shock and mitigates subsequent multiple organ dysfunction syndrome. Prehospital blood programs must be thoughtfully planned, have multiple safeguards, ensure adequate training and credentialing processes, and be responsible stewards of blood resources. According to the 2022 best practices model by Yazer et al, the four key pillars of a successful prehospital program include the following: (1) the rationale for the use and a description of blood products that can be transfused in the prehospital setting, (2) storage of blood products outside the hospital blood bank and how to move them to the patient in the prehospital setting, (3) prehospital transfusion criteria and administration personnel, and (4) documentation of prehospital transfusion and handover to the hospital team...
April 2024: Journal of the American College of Emergency Physicians open
https://read.qxmd.com/read/38519521/a-fungal-core-effector-exploits-the-ospux8b-2-oscdc48-6-module-to-suppress-plant-immunity
#4
JOURNAL ARTICLE
Xuetao Shi, Xin Xie, Yuanwen Guo, Junqi Zhang, Ziwen Gong, Kai Zhang, Jie Mei, Xinyao Xia, Haoxue Xia, Na Ning, Yutao Xiao, Qing Yang, Guo-Liang Wang, Wende Liu
Proteins containing a ubiquitin regulatory X (UBX) domain are cofactors of Cell Division Cycle 48 (CDC48) and function in protein quality control. However, whether and how UBX-containing proteins participate in host-microbe interactions remain unclear. Here we show that MoNLE1, an effector from the fungal pathogen Magnaporthe oryzae, is a core virulence factor that suppresses rice immunity by specifically interfering with OsPUX8B.2. The UBX domain of OsPUX8B.2 is required for its binding to OsATG8 and OsCDC48-6 and controls its 26 S proteasome-dependent stability...
March 22, 2024: Nature Communications
https://read.qxmd.com/read/38517735/determining-ultra-low-organic-molecular-odor-thresholds-in-air-helps-identify-the-most-potent-fungal-aroma-compound
#5
JOURNAL ARTICLE
Fabio F Brescia, Jan Passinger, Raffael C Wende, Peter R Schreiner, Holger Zorn, Marco A Fraatz
The determination of odor threshold values can be performed in various matrices, including air, and serves as a parameter to compare the potencies of odorous compounds. Typically, the odor thresholds in air are determined by gas chromatography-olfactory (GC-O) and referenced to an internal standard, most often ( E )-dec-2-enal. Herein, a direct gas chromatography-flame ionization detector-olfactory analysis method for the determination of odor thresholds in air is reported. As model substrates for this novel approach, naturally occurring substances ( R )-1- p -menthene-8-thiol as well as (3 S ,3a S ,6 R ,7a S )-3,6-dimethyl-3a,4,5,6,7,7a-hexahydro-3 H -1-benzofuran-2-one were used...
March 22, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38509321/nonlinear-pharmacokinetics-of-topical-flurbiprofen-gel-in-a-phase-i-study-among-chinese-healthy-adults
#6
JOURNAL ARTICLE
Wending Xiao, Zhihong Zhu, Feifan Xie, Feiyan Liu, Zeneng Cheng
INTRODUCTION: PDX-02 (Flurbiprofen sodium) is a topical nonsteroidal anti-inflammatory drug in gel formulation for local analgesia and anti-inflammation. A Phase I clinical trial was conducted to assess the safety, tolerability, and pharmacokinetics of single and multiple doses of PDX-02 gel in Chinese healthy adults. METHODS: The trial comprised three parts: (1) a single-dose ascending study with three dose levels (0.5%, 1% to 2% PDX-02 gel) applied on a 136 cm2 skin area; (2) a multiple-dose study with either 1% or 2% PDX-02 gel applied on a 136 cm2 skin area for 7 consecutive days; and (3) a high dose group with 2% PDX-02 gel on an 816 cm2 skin area and a frequent multiple dose group with 2% PDX-02 gel on a 272 cm2 skin area four times a day for 7 consecutive days...
March 20, 2024: Pharmaceutical Research
https://read.qxmd.com/read/38488788/a-verticillium-dahliae-exoglucanase-as-potential-higs-target-interacts-with-a-cotton-cysteine-protease-to-confer-resistance-to-cotton-verticillium-wilt
#7
JOURNAL ARTICLE
Xiaofeng Su, Qi Wang, Tao Zhang, Xiaoyang Ge, Wende Liu, Huiming Guo, Xingfen Wang, Zhengwen Sun, Zhiqiang Li, Hongmei Cheng
No abstract text is available yet for this article.
March 15, 2024: Plant Biotechnology Journal
https://read.qxmd.com/read/38488458/online-and-offline-effects-of-parietal-10%C3%A2-hz-repetitive-transcranial-magnetic-stimulation-on-working-memory-in-healthy-controls
#8
JOURNAL ARTICLE
Xinping Deng, Xiongying Chen, Yang Li, Bofan Zhang, Wending Xu, Jue Wang, Yu-Feng Zang, Qi Dong, Chuansheng Chen, Jun Li
Parietal alpha activity shows a specific pattern of phasic changes during working memory. It decreases during the encoding and recall phases but increases during the maintenance phase. This study tested whether online rTMS delivered to the parietal cortex during the maintenance phase of a working memory task would increase alpha activity and hence improve working memory. Then, 46 healthy volunteers were randomly assigned to two groups to receive 3-day parietal 10 Hz online rTMS (either real or sham, 3600 pulses in total) that were time-locked to the maintenance phase of a spatial span task (180 trials in total)...
March 2024: Human Brain Mapping
https://read.qxmd.com/read/38485747/defining-porphyromonas-gingivalis-strains-associated-with-periodontal-disease
#9
JOURNAL ARTICLE
Vijaya Murugaiyan, Simran Utreja, Kathleen M Hovey, Yijun Sun, Michael J LaMonte, Jean Wactawski-Wende, Patricia I Diaz, Michael J Buck
Porphyromonas gingivalis, a Gram-negative anaerobic bacterium commonly found in human subgingival plaque, is a major etiologic agent for periodontitis and has been associated with multiple systemic pathologies. Many P. gingivalis strains have been identified and different strains possess different virulence factors. Current oral microbiome approaches (16S or shotgun) have been unable to differentiate P. gingivalis strains. This study presents a new approach that aims to improve the accuracy of strain identification, using a detection method based on sequencing of the intergenic spacer region (ISR) which is variable between P...
March 14, 2024: Scientific Reports
https://read.qxmd.com/read/38484967/assessing-the-accessibility-engagement-and-value-of-the-virtual-global-spine-conference-as-an-educational-platform-for-spine-a-three-year-review
#10
JOURNAL ARTICLE
Amna Hussein, Khoi Than, Wende Gibbs, Jonathan Rasouli, Nader S Dahdaleh, Michael Selby, Michael Galgano, Alexander Mameghani, Matthew L Goodwin, John Shin, Alfredo Guiroy, Ali Baaj
INTRODUCTION: The COVID-19 pandemic ushered a paradigm shift in medical education, accelerating the transition to virtual learning in select cases. The Virtual Global Spine Conference (VGSC), launched at the height of the pandemic, is a testament to this evolution, providing an independent educational series for spine care professionals worldwide. This study assesses VGSC's three-year performance, focusing on accessibility, engagement, and educational value. METHODOLOGY: Through retrospective data analysis from April 2020 to August 2023, we examined our social media metrics to measure VGSC's reach and impact...
March 12, 2024: World Neurosurgery
https://read.qxmd.com/read/38475531/endophytic-fungal-diversity-of-mangrove-ferns-acrostichum-speciosum-and-a-aureum-in-china
#11
JOURNAL ARTICLE
Hongjuan Zhu, Wending Zeng, Manman Chen, Dan He, Xialan Cheng, Jing Yu, Ya Liu, Yougen Wu, Dongmei Yang
Microbial communities are an important component of mangrove ecosystems. In order to reveal the diversity of endophytic fungi in the mangrove ferns Acrostichum speciosum and A. aureum in China, the internal transcribed spacer (ITS) regions of endophytic fungi in four plant tissues (leaves, petioles, roots, and rhizomes) from three locations (Zhanjiang, Haikou, and Wenchang) were sequenced. The richness, species composition, and community similarity were analyzed. The main results are as follows: the dominant fungi in A...
February 29, 2024: Plants (Basel, Switzerland)
https://read.qxmd.com/read/38468348/liquid-liquid-phase-separation-of-h3k27me3-reader-bp1-regulates-transcriptional-repression
#12
JOURNAL ARTICLE
Guangfei Tang, Haoxue Xia, Yufei Huang, Yuanwen Guo, Yun Chen, Zhonghua Ma, Wende Liu
BACKGROUND: Bromo-adjacent homology-plant homeodomain domain containing protein 1 (BP1) is a reader of histone post-translational modifications in fungi. BP1 recognizes trimethylation of lysine 27 in histone H3 (H3K27me3), an epigenetic hallmark of gene silencing. However, whether and how BP1 participates in transcriptional repression remains poorly understood. RESULTS: We report that BP1 forms phase-separated liquid condensates to modulate its biological function in Fusarium graminearum...
March 11, 2024: Genome Biology
https://read.qxmd.com/read/38467003/long-term-effect-of-randomization-to-calcium-and-vitamin-d-supplementation-on-health-in-older-women-postintervention-follow-up-of-a-randomized-clinical-trial
#13
JOURNAL ARTICLE
Cynthia A Thomson, Aaron K Aragaki, Ross L Prentice, Marcia L Stefanick, JoAnn E Manson, Jean Wactawski-Wende, Nelson B Watts, Linda Van Horn, James M Shikany, Thomas E Rohan, Dorothy S Lane, Robert A Wild, Rogelio Robles-Morales, Aladdin H Shadyab, Nazmus Saquib, Jane Cauley
BACKGROUND: Although calcium and vitamin D (CaD) supplementation may affect chronic disease in older women, evidence of long-term effects on health outcomes is limited. OBJECTIVE: To evaluate long-term health outcomes among postmenopausal women in the Women's Health Initiative CaD trial. DESIGN: Post hoc analysis of long-term postintervention follow-up of the 7-year randomized intervention trial of CaD. (ClinicalTrials.gov: NCT00000611). SETTING: A multicenter ( n = 40) trial across the United States...
March 12, 2024: Annals of Internal Medicine
https://read.qxmd.com/read/38459975/physical-function-trajectory-after-wrist-or-lower-arm-fracture-in-postmenopausal-women-results-from-the-women-s-health-initiative-study
#14
JOURNAL ARTICLE
Carolyn J Crandall, Joseph Larson, Aladdin H Shadyab, Meryl S LeBoff, Jean Wactawski-Wende, Julie C Weitlauf, Nazmus Saquib, Jane A Cauley, Juliann Saquib, Kristine E Ensrud
UNLABELLED: Long-term physical functioning trajectories following distal forearm fracture are unknown. We found that women with versus those without distal forearm fracture were more likely to experience a 5-year decline in physical functioning, independent of initial physical functioning level. This association was most evident among women 80 years and older. INTRODUCTION: Physical functioning trajectory following lower arm or wrist fracture is not well understood...
March 9, 2024: Osteoporosis International
https://read.qxmd.com/read/38455012/probing-the-stability-of-metal-organic-frameworks-by-structure-responsive-mass-spectrometry-imaging
#15
JOURNAL ARTICLE
Yue Lin, Ke Min, Wende Ma, Xuezhi Yang, Dawei Lu, Zhenyu Lin, Qian Liu, Guibin Jiang
The widespread application of metal-organic frameworks (MOFs) is seriously hindered by their structural instability and it is still very challenging to probe the stability of MOFs during application by current techniques. Here, we report a novel structure-responsive mass spectrometry (SRMS) imaging technique to probe the stability of MOFs. We discovered that intact CuBTC (as a model of MOFs) could generate the characteristic peaks of organic ligands and carbon cluster anions in laser desorption/ionization mass spectrometry, but these peaks were significantly changed when the structure of CuBTC was dissociated, thus enabling a label-free probing of the stability...
March 6, 2024: Chemical Science
https://read.qxmd.com/read/38453301/prehospital-trauma-care
#16
REVIEW
Christopher M Wend, Ryan B Fransman, Elliott R Haut
Prehospital trauma evaluation begins with the primary assessment of airway, breathing, circulation, disability, and exposure. This is closely followed by vital signs and a secondary assessment. Key prehospital interventions include management and resuscitation according to the aforementioned principles with a focus on major hemorrhage control, airway compromise, and invasive management of tension pneumothorax. Determining the appropriate time and method for transportation (eg, ground ambulance, helicopter, police, private vehicle) to the hospital or when to terminate resuscitation are also important decisions to be made by emergency medical services clinicians...
April 2024: Surgical Clinics of North America
https://read.qxmd.com/read/38451003/rethinking-the-tiered-trauma-team-response-a-case-series-study-in-a-regional-trauma-centre
#17
JOURNAL ARTICLE
Kate Curtis, Benjamin Clark, Mary K Lam, Ryan Huckle, Geoffrey Melville, Simon Binks, Ms Wende Ryan, Trevor Gardner, Ms Brooke Parsons, Bruce Ashford
OBJECTIVE: To reduce perceived unnecessary resource use, we modified our tiered trauma response. If a patient was not physiologically compromised, surgical registrar attendance was not mandated. We investigated the effect of this change on missed injury, unplanned representation to ED, diagnostic imaging rates and staff satisfaction. METHODS: A retrospective case series study assessing the 3-month period before and after the intervention was conducted. Logistic regression analyses were used to examine the association between ordering of computerised tomography (CT) and ED length of stay (LOS), injury severity (ISS), age, surgical review and admission...
March 7, 2024: Emergency Medicine Australasia: EMA
https://read.qxmd.com/read/38443593/neuron-astrocyte-metabolic-coupling-facilitates-spinal-plasticity-and-maintenance-of-inflammatory-pain
#18
JOURNAL ARTICLE
Sebastián Marty-Lombardi, Shiying Lu, Wojciech Ambroziak, Katrin Schrenk-Siemens, Jialin Wang, Anna A DePaoli-Roach, Anna M Hagenston, Hagen Wende, Anke Tappe-Theodor, Manuela Simonetti, Hilmar Bading, Jürgen G Okun, Rohini Kuner, Thomas Fleming, Jan Siemens
Long-lasting pain stimuli can trigger maladaptive changes in the spinal cord, reminiscent of plasticity associated with memory formation. Metabolic coupling between astrocytes and neurons has been implicated in neuronal plasticity and memory formation in the central nervous system, but neither its involvement in pathological pain nor in spinal plasticity has been tested. Here we report a form of neuroglia signalling involving spinal astrocytic glycogen dynamics triggered by persistent noxious stimulation via upregulation of the Protein Targeting to Glycogen (PTG) in spinal astrocytes...
March 5, 2024: Nature metabolism
https://read.qxmd.com/read/38440430/unusual-intra-tracheal-migration-of-a-corrosive-esophageal-foreign-body
#19
JOURNAL ARTICLE
Richard Wend-Lasida Ouédraogo, Ibraïma Traore, Mathieu Millogo
Introduction : intra-tracheal migration of esophageal foreign body is very uncommon and dangerous. It is most often caused by a vulnerable foreign body accidentally swallowed. We report the first observation of intra-tracheal migration of corrosive battery in our practice, with review of the literature. Observation : It was a three-years-old girl received in ENT with dyspnea occurred on a chronic dysphagia. The chest x-ray revealed an endotracheal opacity. This proved to be a button battery that migrated into the trachea through an eso-tracheal perforation...
February 2024: Indian Journal of Otolaryngology and Head and Neck Surgery
https://read.qxmd.com/read/38428809/imaging-of-adult-malignant-soft-tissue-tumors-of-the-spinal-canal-a-guide-for-spine-surgeons
#20
REVIEW
Gaelle Haddad, Charbel Moussalem, Marie Christelle Saade, Mario El Hayek, Elie Massaad, Wende N Gibbs, John Shin
BACKGROUND: Interpretation of malignant soft tissue spinal canal tumors imaging is essential in guiding spine surgeons to establish a differential diagnosis. This task is intricate due to a great radiologic pattern overlap among entities. We present in this manuscript a step-by-step strategy that can guide spine surgeons identify a likely malignant soft tissue lesion in the spinal canal based on imaging features. In addition, we provide a review of the radiologic features of malignant soft tissue spinal canal tumors, assisting spine surgeons refining their diagnostic approach based on several essential imaging characteristics...
February 28, 2024: World Neurosurgery
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