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https://www.readbyqxmd.com/read/29316944/car-t-cells-targeting-cll-1-as-an-approach-to-treat-acute-myeloid-leukemia
#1
Jinghua Wang, Siyu Chen, Wei Xiao, Wende Li, Liang Wang, Shuo Yang, Weida Wang, Liping Xu, Shuangye Liao, Wenjian Liu, Yang Wang, Nawei Liu, Jianeng Zhang, Xiaojun Xia, Tiebang Kang, Gong Chen, Xiuyu Cai, Han Yang, Xing Zhang, Yue Lu, Penghui Zhou
BACKGROUND: Acute myeloid leukemia (AML) is one of the most common types of adult acute leukemia. Standard chemotherapies can induce complete remission in selected patients; however, a majority of patients eventually relapse and succumb to the disease. Thus, the development of novel therapeutics for AML is urgently needed. Human C-type lectin-like molecule-1 (CLL-1) is a type II transmembrane glycoprotein, and its expression is restricted to myeloid cells and the majority of AML blasts...
January 10, 2018: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/29300466/amorphous-metal-free-room-temperature-phosphorescent-small-molecules-with-multicolor-photoluminescence-via-a-host-guest-and-dual-emission-strategy
#2
Dengfeng Li, Feifei Lu, Jie Wang, Wende Hu, Xiao-Ming Cao, Xiang Ma, He Tian
Metal-free room-temperature phosphorescence (RTP) materials offer unprecedented potentials for photoelectric and biochemical materials due to their unique advantages of long lifetime and low-toxicity. However, the achievements of phosphorescence at ambient condition so far have been mainly focused on ordered crystal lattice or on embedding into rigid matrices, where the preparation process might bring out poor repeatability and limited application. In this research, a series of amorphous organic small molecular compounds were developed with efficient room-temperature phosphorescence (RTP) emission through conveniently modifying phosphor moieties to β-cyclodextrin (β-CD)...
January 4, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29288409/gene-expression-analysis-to-identify-mechanisms-underlying-heart-failure-susceptibility-in-mice-and-humans
#3
Christoph Koentges, Mark E Pepin, Carolyn Müsse, Katharina Pfeil, Sonia V Viteri Alvarez, Natalie Hoppe, Michael M Hoffmann, Katja E Odening, Samuel Sossalla, Andreas Zirlik, Lutz Hein, Christoph Bode, Adam R Wende, Heiko Bugger
Genetic factors are known to modulate cardiac susceptibility to ventricular hypertrophy and failure. To determine how strain influences the transcriptional response to pressure overload-induced heart failure (HF) and which of these changes accurately reflect the human disease, we analyzed the myocardial transcriptional profile of mouse strains with high (C57BL/6J) and low (129S1/SvImJ) susceptibility for HF development, which we compared to that of human failing hearts. Following transverse aortic constriction (TAC), C57BL/6J mice developed overt HF while 129S1/SvImJ did not...
December 29, 2017: Basic Research in Cardiology
https://www.readbyqxmd.com/read/29286412/basic-research-in-plasma-medicine-a-throughput-approach-from-liquids-to-cells
#4
Sander Bekeschus, Anke Schmidt, Felix Niessner, Torsten Gerling, Klaus-Dieter Weltmann, Kristian Wende
In plasma medicine, ionized gases with temperatures close to that of vertebrate systems are applied to cells and tissues. Cold plasmas generate reactive species known to redox regulate biological processes in health and disease. Pre-clinical and clinical evidence points to beneficial effects of plasma treatment in the healing of chronic ulcer of the skin. Other emerging topics, such as plasma cancer treatment, are receiving increasing attention. Plasma medical research requires interdisciplinary expertise in physics, chemistry, and biomedicine...
November 17, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29223446/structural-and-functional-conservation-of-cis-acting-rna-elements-in-coronavirus-5-terminal-genome-regions
#5
Ramakanth Madhugiri, Nadja Karl, Daniel Petersen, Kevin Lamkiewicz, Markus Fricke, Ulrike Wend, Robina Scheuer, Manja Marz, John Ziebuhr
Structure predictions suggest a partial conservation of RNA structure elements in coronavirus terminal genome regions. Here, we determined the structures of stem-loops (SL) 1 and 2 of two alphacoronaviruses, human coronavirus (HCoV) 229E and NL63, by RNA structure probing and studied the functional relevance of these putative cis-acting elements. HCoV-229E SL1 and SL2 mutants generated by reverse genetics were used to study the effects on viral replication of single-nucleotide substitutions predicted to destabilize the SL1 and SL2 structures...
December 6, 2017: Virology
https://www.readbyqxmd.com/read/29213349/oxidants-and-redox-signaling-perspectives-in-cancer-therapy-inflammation-and-plasma-medicine
#6
EDITORIAL
Sander Bekeschus, Lars Bräutigam, Kristian Wende, Eva-Maria Hanschmann
No abstract text is available yet for this article.
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29210429/probing-magnetic-coupling-between-lnpc2-ln-tb-er-molecules-and-the-graphene-ni-111-substrate-with-and-without-au-intercalation-role-of-the-dipolar-field
#7
V Corradini, A Candini, D Klar, R Biagi, V De Renzi, A Lodi Rizzini, N Cavani, U Del Pennino, S Klyatskaya, M Ruben, E Velez-Fort, K Kummer, N B Brookes, P Gargiani, H Wende, M Affronte
Lanthanides (Ln) bis-phthalocyanine (Pc), the so-called LnPc2double decker, are a promising class of molecules with a well-defined magnetic anisotropy. In this work, we investigate the magnetic properties of LnPc2 molecules UHV-deposited on a graphene/Ni(111) substrate and how they modify when an Au layer is intercalated between Ni and graphene. X-ray absorption spectroscopy (XAS), and linear and magnetic circular dichroism (XLD and XMCD) were used to characterize the systems and probe the magnetic coupling between LnPc2 molecules and the Ni substrate through graphene, both gold-intercalated and not...
December 6, 2017: Nanoscale
https://www.readbyqxmd.com/read/29205603/selective-profiling-of-saponins-from-gypsophila-trichotoma-wend-by-hilic-separation-and-hrms-detection
#8
Reneta Gevrenova, Ventzislav Bardarov, Krum Bardarov, Laurence Voutquenne-Nazabadioko, Max Henry
INTRODUCTION: Roots of Gypsophila trichotoma Wend. (Caryophyllaceae) are rich sources of glucuronide oleanane-type triterpenoid carboxylic acid 3,28-O-bidesmosides (GOTCABs). These saponins have been reported to possess synergistic cytotoxicity in combination with type I ribosome-inactivating protein saporin. OBJECTIVE: To develop ultra high-performance liquid chromatography - electrospray ionisation/high resolution mass spectrometry (UHPLC-ESI/HRMS) acquisition strategy for the recognition of Gypsophila GOTCAB saponins...
December 4, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/29198300/sleep-and-breast-cancer-in-the-western-new-york-exposures-and-breast-cancer-web-study
#9
Caila B Vaughn, Jo L Freudenheim, Jing Nie, Lara Sucheston-Campbell, Jean Wactawski-Wende, Catalin Marian, Peter G Shields, Bhaskar V Kallakury, Maurizio Trevisan, Heather M Ochs-Balcom
STUDY OBJECTIVES: Night shift work is associated with increased breast cancer risk, possibly from altered sleep. Epidemiologic evidence is sparse regarding sleep disturbances and breast cancer tumor markers. We examined sleep disturbance in association with breast tumor aggressiveness and mortality following diagnosis. METHODS: We analyzed associations of measures of sleep disturbance in a sample of 1,122 incident breast cancer cases from the Western New York Exposures and Breast Cancer (WEB) Study...
November 29, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29145463/the-chicken-or-the-egg-exploring-bi-directional-associations-between-newcastle-disease-vaccination-and-village-chicken-flock-size-in-rural-tanzania
#10
Julia de Bruyn, Peter C Thomson, Brigitte Bagnol, Wende Maulaga, Elpidius Rukambile, Robyn G Alders
Newcastle disease (ND) is a viral disease of poultry with global importance, responsible for the loss of a potential source of household nutrition and economic livelihood in many low-income food-deficit countries. Periodic outbreaks of this endemic disease result in high mortality amongst free-ranging chicken flocks and may serve as a disincentive for rural households to invest time or resources in poultry-keeping. Sustainable ND control can be achieved through vaccination using a thermotolerant vaccine administered via eyedrop by trained "community vaccinators"...
2017: PloS One
https://www.readbyqxmd.com/read/29135897/is-bmi-a-valid-measure-of-obesity-in-postmenopausal-women
#11
Hailey R Banack, Jean Wactawski-Wende, Kathleen M Hovey, Andrew Stokes
OBJECTIVE: Body mass index (BMI) is a widely used indicator of obesity status in clinical settings and population health research. However, there are concerns about the validity of BMI as a measure of obesity in postmenopausal women. Unlike BMI, which is an indirect measure of obesity and does not distinguish lean from fat mass, dual-energy x-ray absorptiometry (DXA) provides a direct measure of body fat and is considered a gold standard of adiposity measurement. The goal of this study is to examine the validity of using BMI to identify obesity in postmenopausal women relative to total body fat percent measured by DXA scan...
November 13, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29126231/irrigation-management-and-phosphorus-addition-alter-the-abundance-of-carbon-dioxide-fixing-autotrophs-in-phosphorus-limited-paddy-soil
#12
Xiaohong Wu, Tida Ge, Wende Yan, Juan Zhou, Xiaomeng Wei, Liang Chen, Xiangbi Chen, Paolo Nannipieri, Jinshui Wu
In this study, we assessed the interactive effects of phosphorus (P) application and irrigation methods on the abundances of marker genes (cbbL, cbbM, accA, and aclB) of CO2-fixing autotrophs. We conducted rice-microcosm experiments using a P-limited paddy soil, with and without the addition of P fertiliser (P versus CK), and using two irrigation methods, namely alternate wetting and drying (AWD) and continuous flooding (CF). The abundances of bacterial 16S rRNA, archaeal 16S rRNA, cbbL, cbbM, accA, and aclB genes in the rhizosphere soil (RS) and bulk soil (BS) were quantified...
November 8, 2017: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/29116125/erratum-large-meta-analysis-of-genome-wide-association-studies-identifies-five-loci-for-lean-body-mass
#13
M Carola Zillikens, Serkalem Demissie, Yi-Hsiang Hsu, Laura M Yerges-Armstrong, Wen-Chi Chou, Lisette Stolk, Gregory Livshits, Linda Broer, Toby Johnson, Daniel L Koller, Zoltán Kutalik, Jian'an Luan, Ida Malkin, Janina S Ried, Albert V Smith, Gudmar Thorleifsson, Liesbeth Vandenput, Jing Hua Zhao, Weihua Zhang, Ali Aghdassi, Kristina Åkesson, Najaf Amin, Leslie J Baier, Inês Barroso, David A Bennett, Lars Bertram, Rainer Biffar, Murielle Bochud, Michael Boehnke, Ingrid B Borecki, Aron S Buchman, Liisa Byberg, Harry Campbell, Natalia Campos Obanda, Jane A Cauley, Peggy M Cawthon, Henna Cederberg, Zhao Chen, Nam H Cho, Hyung Jin Choi, Melina Claussnitzer, Francis Collins, Steven R Cummings, Philip L De Jager, Ilja Demuth, Rosalie A M Dhonukshe-Rutten, Luda Diatchenko, Gudny Eiriksdottir, Anke W Enneman, Mike Erdos, Johan G Eriksson, Joel Eriksson, Karol Estrada, Daniel S Evans, Mary F Feitosa, Mao Fu, Melissa Garcia, Christian Gieger, Thomas Girke, Nicole L Glazer, Harald Grallert, Jagvir Grewal, Bok-Ghee Han, Robert L Hanson, Caroline Hayward, Albert Hofman, Eric P Hoffman, Georg Homuth, Wen-Chi Hsueh, Monica J Hubal, Alan Hubbard, Kim M Huffman, Lise B Husted, Thomas Illig, Erik Ingelsson, Till Ittermann, John-Olov Jansson, Joanne M Jordan, Antti Jula, Magnus Karlsson, Kay-Tee Khaw, Tuomas O Kilpeläinen, Norman Klopp, Jacqueline S L Kloth, Heikki A Koistinen, William E Kraus, Stephen Kritchevsky, Teemu Kuulasmaa, Johanna Kuusisto, Markku Laakso, Jari Lahti, Thomas Lang, Bente L Langdahl, Lenore J Launer, Jong-Young Lee, Markus M Lerch, Joshua R Lewis, Lars Lind, Cecilia Lindgren, Yongmei Liu, Tian Liu, Youfang Liu, Östen Ljunggren, Mattias Lorentzon, Robert N Luben, William Maixner, Fiona E McGuigan, Carolina Medina-Gomez, Thomas Meitinger, Håkan Melhus, Dan Mellström, Simon Melov, Karl Michaëlsson, Braxton D Mitchell, Andrew P Morris, Leif Mosekilde, Anne Newman, Carrie M Nielson, Jeffrey R O'Connell, Ben A Oostra, Eric S Orwoll, Aarno Palotie, Stephen C J Parker, Munro Peacock, Markus Perola, Annette Peters, Ozren Polasek, Richard L Prince, Katri Räikkönen, Stuart H Ralston, Samuli Ripatti, John A Robbins, Jerome I Rotter, Igor Rudan, Veikko Salomaa, Suzanne Satterfield, Eric E Schadt, Sabine Schipf, Laura Scott, Joban Sehmi, Jian Shen, Chan Soo Shin, Gunnar Sigurdsson, Shad Smith, Nicole Soranzo, Alena Stančáková, Elisabeth Steinhagen-Thiessen, Elizabeth A Streeten, Unnur Styrkarsdottir, Karin M A Swart, Sian-Tsung Tan, Mark A Tarnopolsky, Patricia Thompson, Cynthia A Thomson, Unnur Thorsteinsdottir, Emmi Tikkanen, Gregory J Tranah, Jaakko Tuomilehto, Natasja M van Schoor, Arjun Verma, Peter Vollenweider, Henry Völzke, Jean Wactawski-Wende, Mark Walker, Michael N Weedon, Ryan Welch, H-Erich Wichmann, Elisabeth Widen, Frances M K Williams, James F Wilson, Nicole C Wright, Weijia Xie, Lei Yu, Yanhua Zhou, John C Chambers, Angela Döring, Cornelia M van Duijn, Michael J Econs, Vilmundur Gudnason, Jaspal S Kooner, Bruce M Psaty, Timothy D Spector, Kari Stefansson, Fernando Rivadeneira, André G Uitterlinden, Nicholas J Wareham, Vicky Ossowski, Dawn Waterworth, Ruth J F Loos, David Karasik, Tamara B Harris, Claes Ohlsson, Douglas P Kiel
A correction to this article has been published and is linked from the HTML version of this article.
November 7, 2017: Nature Communications
https://www.readbyqxmd.com/read/29098763/characterising-infant-and-young-child-feeding-practices-and-the-consumption-of-poultry-products-in-rural-tanzania-a-mixed-methods-approach
#14
Julia De Bruyn, Brigitte Bagnol, Ian Darnton-Hill, Wende Maulaga, Peter C Thomson, Robyn Alders
Suboptimal breastfeeding practices, early initiation of complementary feeding, and monotonous cereal-based diets have been implicated as contributors to continuing high rates of child undernutrition in sub-Saharan Africa. Nutrition-sensitive interventions, including agricultural programs that increase access to nutrient-rich vegetables, legumes, and animal-source foods, have the potential to achieve sustainable improvements in children's diets. In the quest to evaluate the efficacy of such programs in improving growth and development in the first 2 years of life, there is a role for mixed methods research to better understand existing infant and young child feeding practices...
November 2, 2017: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/29098029/synergistic-anti-proliferative-and-pro-apoptotic-activities-of-5f-and-cisplatin-in-human-non-small-cell-lung-cancer-nci-h23-cells
#15
Yuchan Li, Wende Li, Wusheng Deng, Yuhong Gan, Kefeng Wu, Jie Sun
Two-drug combination chemotherapy, often including cisplatin and one other drug, remains the standard of care for patients with advanced non-small cell lung cancer (NSCLC). To improve the treatment of late-stage NSCLC and decrease the toxicity of combination chemotherapy, the search for novel drugs remains vigorous. Ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic acid (5F), a bioactive compound isolated from the herb Pteris semipinnata L., has previously been shown to induce apoptosis and inhibit proliferation in various cancer cells...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29092894/mitochondrial-reactive-oxygen-species-in-lipotoxic-hearts-induces-post-translational-modifications-of-akap121-drp1-and-opa1-that-promote-mitochondrial-fission
#16
Kensuke Tsushima, Heiko Bugger, Adam R Wende, Jamie Soto, Gregory A Jenson, Austin R Tor, Rose McGlauflin, Helena C Kenny, Yuan Zhang, Rhonda Souvenir, Xiao X Hu, Crystal L Black, Renata O Pereira, Vitor A Lira, Kenneth Spitzer, Terry L Sharp, Kooresh I Shoghi, Genevieve C Sparagna, Eva A Rog-Zielinska, Peter Kohl, Oleh Khalimonchuk, Jean E Schaffer, E Dale Abel
Rationale: Cardiac lipotoxicity, characterized by increased uptake, oxidation and accumulation of lipid intermediates, contributes to cardiac dysfunction in obesity and diabetes. However, mechanisms linking lipid overload and mitochondrial dysfunction are incompletely understood. Objective: To elucidate the mechanisms for mitochondrial adaptations to lipid overload in postnatal hearts in vivo. Methods and Results: Using a transgenic mouse model of cardiac lipotoxicity overexpressing long-chain acyl-CoA synthetase 1 in cardiomyocytes, we show that modestly increased myocardial fatty acid uptake leads to mitochondrial structural remodeling with significant reduction in minimum diameter...
November 1, 2017: Circulation Research
https://www.readbyqxmd.com/read/29092231/tunable-dual-wavelength-fiber-laser-with-unique-gain-system-based-on-in-fiber-acousto-optic-mach-zehnder-interferometer
#17
Na Yan, Xiaofang Han, Pengfa Chang, Ligang Huang, Feng Gao, Xuanyi Yu, Wending Zhang, Ze Zhang, Guoquan Zhang, Jingjun Xu
A fast tunable dual-wavelength laser based on in-fiber acousto-optic Mach-Zehnder interferometer (AO-MZI) with new fabrication process is proposed. Not only could the center wavelength of the output laser be optimized with enhanced tuning range about 30 nm by tuning the polarization and the driving frequency of the radio frequency (RF) signal accordingly, but also the spectral spacing between the two output wavelengths could be tuned from ~0 nm to 2.65 nm by controlling the power of the RF signal. The tuning mechanism was also discussed...
October 30, 2017: Optics Express
https://www.readbyqxmd.com/read/29081036/microrna-378-enhances-radiation-response-in-ectopic-and-orthotopic-implantation-models-of-glioblastoma
#18
Wende Li, Yujiao Liu, Weining Yang, Xiaoxing Han, Sen Li, Hao Liu, Leo E Gerweck, Dai Fukumura, Jay S Loeffler, Burton B Yang, Rakesh K Jain, Peigen Huang
Glioblastoma multiforme (GBM) is the most common and highly malignant primary brain tumor, which is virtually incurable due to its therapeutic resistance to radiation and chemotherapy. To develop novel therapeutic approaches for treatment of GBM, we examined the role of miR-378 on tumor growth, angiogenesis, and radiation response in ectopic and orthotopic U87 glioblastoma models. Cell and tumor growth rates, in vitro and in vivo radiation sensitivities, and tumor vascular density were evaluated in U87-GFP and U87-miR-378 tumor lines...
October 28, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29071440/reduction-of-the-relative-centrifugal-force-influences-cell-number-and-growth-factor-release-within-injectable-prf-based-matrices
#19
Simon Wend, Alica Kubesch, Anna Orlowska, Sarah Al-Maawi, Niklas Zender, Andre Dias, Richard J Miron, Robert Sader, Patrick Booms, C James Kirkpatrick, Joseph Choukroun, Shahram Ghanaati
Platelet rich fibrin (PRF) is a blood concentrate system obtained by centrifugation of peripheral blood. First PRF matrices exhibited solid fibrin scaffold, more recently liquid PRF-based matrix was developed by reducing the relative centrifugation force and time. The aim of this study was to systematically evaluate the influence of RCF (relative centrifugal force) on cell types and growth factor release within injectable PRF- in the range of 60-966 g using consistent centrifugation time. Numbers of cells was analyzed using automated cell counting (platelets, leukocytes, neutrophils, lymphocytes and monocytes) and histomorphometrically (CD 61, CD- 45, CD-15+, CD-68+, CD-3+ and CD-20)...
October 25, 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/29067752/recent-attempted-and-actual-weight-change-in-relation-to-pregnancy-loss-a-prospective-cohort-study
#20
R G Radin, S L Mumford, L A Sjaarda, R M Silver, J Wactawski-Wende, A M Lynch, N J Perkins, L L Lesher, B D Wilcox, S N Hinkle, T C Plowden, K Kim, E F Schisterman
OBJECTIVE: To assess weight change and attempted weight loss during the 12-18 months before spontaneous conception in relation to the risk of pregnancy loss. DESIGN: Prospective cohort study. SETTING: United States, 2007-2011. METHODS: Women (n = 629) who were attempting pregnancy reported at baseline any weight loss attempts over the past 12 months, and their minimum and maximum weights during that time. Follow up lasted one to six menstrual cycles and throughout pregnancy...
October 25, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
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