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https://www.readbyqxmd.com/read/28530095/rational-design-of-bacillus-coagulans-nl01-l-arabinose-isomerase-and-using-its-f279i-variant-in-d-tagatose-production
#1
Zhaojuan Zheng, Wending Mei, Meijuan Xia, Qin He, Jia Ouyang
D-tagatose is a prospective functional sweetener that can be produced by L-arabinose isomerase (AI) from D-galactose. To improve the activity of AI toward D-galactose, the AI of Bacillus coagulans was rationally designed based on molecular modeling and docking. After alanine scanning and site-saturation mutagenesis, variant F279I that exhibited improved activity toward D-galactose was obtained. The optimal temperature and pH of F279I were determined to be 50°C and 8.0, respectively. This variant possessed 1...
May 22, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28511792/mechanisms-of-hemispheric-lateralization-a-replication-study
#2
Kim C Wende, Catherine Thiel, Jens Sommer, Frieder M Paulus, Sören Krach, Andreas Jansen
It has been shown, using functional magnetic resonance imaging (fMRI), that hemispheric lateralization of brain activity depends on the requirements of the cognitive task performed during the processing of a sensory stimulus rather than on the intrinsic characteristics of that stimulus [Stephan et al., 2003, Science 301 (5631): 384-6]. Task-dependent increase in the coupling of the anterior cingulate cortex (ACC), a region involved in cognitive control, and brain areas in the left prefrontal and right parietal cortex, respectively, regions involved in task execution, was proposed as the mechanism underlying this task-dependency of hemispheric lateralization...
April 22, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28496326/gold-nanoparticles-attenuate-metastasis-by-tumor-vasculature-normalization-and-epithelial-mesenchymal-transition-inhibition
#3
Wei Li, Xin Li, Shuhao Liu, Wende Yang, Fan Pan, Xiao-Yan Yang, Bin Du, Li Qin, Yunlong Pan
Angiogenesis is a process by which vessels are formed through preexisting ones, and this plays a key role in the progression of solid tumors. However, tumor vessels are influenced by excessive pro-angiogenic factors, resulting in deformed structures that facilitate the intravasation of tumor cells into the circulation and subsequent metastasis. Moreover, abnormal tumor vessels have low blood perfusion and thereby decreased oxygen infusion into tumors. This results in a hostile microenvironment that promotes epithelial-mesenchymal transition (EMT), a process in which epithelial cells lose their polarity and gain increased motility, which is associated with metastasis and invasion...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28472845/-utility-analysis-of-oncological-centre-building-in-the-field-of-colorectal-cancer
#4
Ines Weinhold, Tobias Keck, Axel Merseburger, Achim Rody, Barbara Wollenberg, Danny Wende, Dennis Häckl, Christian Elsner
Background In the field of colorectal cancer and other cancer entities, there is an ongoing trend to establish multidisciplinary treatment in specialised cancer centres. Little is known by now about the outcomes of this centralised and quality-driven treatment approach. In light of the increasing cost-benefit discussions, assessments of their impact seem to be necessary. This paper discusses positive effects of cancer centres with a particular focus on the multidisciplinary approach and its potential impact on survival outcomes of colorectal cancer patients...
May 4, 2017: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/28469020/trophic-level-successional-age-and-trait-matching-determine-specialization-of-deadwood-based-interaction-networks-of-saproxylic-beetles
#5
Beate Wende, Martin M Gossner, Ingo Grass, Tobias Arnstadt, Martin Hofrichter, Andreas Floren, Karl Eduard Linsenmair, Wolfgang W Weisser, Ingolf Steffan-Dewenter
The specialization of ecological networks provides important insights into possible consequences of biodiversity loss for ecosystem functioning. However, mostly mutualistic and antagonistic interactions of living organisms have been studied, whereas detritivore networks and their successional changes are largely unexplored. We studied the interactions of saproxylic (deadwood-dependent) beetles with their dead host trees. In a large-scale experiment, 764 logs of 13 tree species were exposed to analyse network structure of three trophic groups of saproxylic beetles over 3 successional years...
May 17, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28417334/sleep-quality-duration-and-breast-cancer-aggressiveness
#6
Allison Soucise, Caila Vaughn, Cheryl L Thompson, Amy E Millen, Jo L Freudenheim, Jean Wactawski-Wende, Amanda I Phipps, Lauren Hale, Lihong Qi, Heather M Ochs-Balcom
PURPOSE: Epidemiological studies suggest that short sleep duration and poor sleep quality may increase breast cancer risk. However, whether sleep is associated with breast tumor aggressiveness characteristics has largely been unexplored. METHODS: The study included 4171 non-Hispanic whites (NHW) and 235 African Americans (AA) diagnosed with incident, primary, invasive breast cancer in the Women's Health Initiative (WHI) Observational Study (1994-2013). We used logistic regression to examine the association of baseline sleep (sleep duration, sleep quality, WHI Insomnia Rating Scale) with tumor grade, stage, hormone receptor status, HER2 status...
April 17, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28408494/o-glcnacylation-and-cardiovascular-disease
#7
REVIEW
JaLessa N Wright, Helen E Collins, Adam R Wende, John C Chatham
The post-translational modification of serine and threonine residues of proteins found in numerous subcellular locations by O-linked N-acetylglucosamine (O-GlcNAc) is emerging as a key mediator of many cardiovascular pathophysiological processes. Early studies implicated increased protein O-GlcNAcylation as contributing to the cardiovascular complications associated with diabetes, whereas subsequent studies demonstrated that acute increases in O-GlcNAc levels were protective against ischemia/reperfusion injury...
April 15, 2017: Biochemical Society Transactions
https://www.readbyqxmd.com/read/28376922/epidemiological-characteristics-of-primary-spinal-osseous-tumors-in-eastern-china
#8
Zhenhua Zhou, Xudong Wang, Zhipeng Wu, Wending Huang, Jianru Xiao
BACKGROUND: Primary spinal osseous tumors are rare, yet they represent a difficult treatment paradigm because of the complexities of tumor resection and significant resistance to chemotherapy and radiation therapy. The geographic distribution of primary spinal osseous tumors throughout the world appears to be quite variable, with a very low incidence reported in Asian countries. METHODS: Data on 1209 cases of primary spinal osseous malignant and benign tumor cases diagnosed during the 20-year period of 1995 through 2015 in eastern China were analyzed...
April 4, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28376149/mammographic-density-change-with-estrogen-and-progestin-therapy-and-breast-cancer-risk
#9
Celia Byrne, Giske Ursin, Christopher F Martin, Jennifer D Peck, Elodia B Cole, Donglin Zeng, Eunhee Kim, Martin D Yaffe, Norman F Boyd, Gerardo Heiss, Anne McTiernan, Rowan T Chlebowski, Dorothy S Lane, JoAnn E Manson, Jean Wactawski-Wende, Etta D Pisano
Background: Estrogen plus progestin therapy increases both mammographic density and breast cancer incidence. Whether mammographic density change associated with estrogen plus progestin initiation predicts breast cancer risk is unknown. Methods: We conducted an ancillary nested case-control study within the Women's Health Initiative trial that randomly assigned postmenopausal women to daily conjugated equine estrogen 0.625 mg plus medroxyprogesterone acetate 2...
September 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28373972/in-vivo-efficacy-and-pharmacokinetics-of-optimized-apidaecin-analogs
#10
Rico Schmidt, Daniel Knappe, Elisabeth Wende, Eszter Ostorházi, Ralf Hoffmann
Proline-rich antimicrobial peptides (PrAMPs) represent promising alternative therapeutic options for the treatment of multidrug-resistant bacterial infections. PrAMPs are predominantly active against Gram-negative bacteria by inhibiting protein expression via at least two different modes of action, i.e., blocking the ribosomal exit tunnel of 70S ribosomes (oncocin-type binding) or inhibiting the assembly of the 50S ribosomal subunit (apidaecin-type binding). The in vivo efficacy and favorable biodistribution of oncocins confirmed the therapeutic potential of short PrAMPs for the first time, whereas the in vivo evaluation of apidaecins is still limited despite the promising efficacy of apidaecin-analog Api88 in an intraperitoneal murine infection model...
2017: Frontiers in Chemistry
https://www.readbyqxmd.com/read/28369063/tablet-computer-enhanced-training-improves-internal-medicine-exam-performance
#11
Daniel C Baumgart, Ilja Wende, Ulrike Grittner
BACKGROUND: Traditional teaching concepts in medical education do not take full advantage of current information technology. We aimed to objectively determine the impact of Tablet PC enhanced training on learning experience and MKSAP® (medical knowledge self-assessment program) exam performance. METHODS: In this single center, prospective, controlled study final year medical students and medical residents doing an inpatient service rotation were alternatingly assigned to either the active test (Tablet PC with custom multimedia education software package) or traditional education (control) group, respectively...
2017: PloS One
https://www.readbyqxmd.com/read/28366425/osteoporosis-in-the-women-s-health-initiative-another-treatment-gap
#12
Maryam Sattari, Jane A Cauley, Cynthia Garvan, Karen C Johnson, Michael J LaMonte, Wenjun Li, Marian Limacher, Todd Manini, Gloria E Sarto, Shannon D Sullivan, Jean Wactawski-Wende, Rebecca J Beyth
BACKGROUND: Osteoporotic fractures are associated with high morbidity, mortality, and cost. METHODS: We performed a post hoc analysis of the Women's Health Initiative (WHI) clinical trials (CT) data to assess osteoporosis treatment and identify participant characteristics associated with utilization of osteoporosis medication(s) after new diagnoses of osteoporosis and/or fracture. Information from visits prior to and immediately subsequent to the first fracture event or osteoporosis diagnosis were evaluated for medication use...
March 30, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28365791/elasticity-and-tumorigenic-characteristics-of-cells-in-a-monolayer-after-nanosecond-pulsed-electric-field-exposure
#13
A Steuer, K Wende, P Babica, J F Kolb
Nanosecond pulsed electric fields (nsPEFs) applied to cells can induce different biological effects depending on pulse duration and field strength. One known process is the induction of apoptosis whereby nsPEFs are currently investigated as a novel cancer therapy. Another and probably related change is the breakdown of the cytoskeleton. We investigated the elasticity of rat liver epithelial cells WB-F344 in a monolayer using atomic force microscopy (AFM) with respect to the potential of cells to undergo malignant transformation or to develop a potential to metastasize...
April 1, 2017: European Biophysics Journal: EBJ
https://www.readbyqxmd.com/read/28356279/history-of-periodontitis-diagnosis-and-edentulism-as-predictors-of-cardiovascular-disease-stroke-and-mortality-in-postmenopausal-women
#14
Michael J LaMonte, Robert J Genco, Kathleen M Hovey, Robert B Wallace, Jo L Freudenheim, Dominique S Michaud, Xiaodan Mai, Lesley F Tinker, Christian R Salazar, Christopher A Andrews, Wenjun Li, Charles B Eaton, Lisa W Martin, Jean Wactawski-Wende
BACKGROUND: Few studies have reported associations between periodontitis and cardiovascular disease (CVD) risk in older women, which is the objective of the present investigation. METHODS AND RESULTS: Participants were 57 001 postmenopausal women ages 55 to 89 years (mean 68 years; >85% 60 and older) who were enrolled (1993-1998) in the Women's Health Initiative Observational Study, and were without known CVD when history of periodontitis and edentulism was assessed by questionnaire at study Year-5 (1998-2003)...
March 29, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28355222/transaldolase-inhibition-impairs-mitochondrial-respiration-and-induces-a-starvation-like-longevity-response-in-caenorhabditis-elegans
#15
Christopher F Bennett, Jane J Kwon, Christine Chen, Joshua Russell, Kathlyn Acosta, Nikolay Burnaevskiy, Matthew M Crane, Alessandro Bitto, Helen Vander Wende, Marissa Simko, Victor Pineda, Ryan Rossner, Brian M Wasko, Haeri Choi, Shiwen Chen, Shirley Park, Gholamali Jafari, Bryan Sands, Carissa Perez Olsen, Alexander R Mendenhall, Philip G Morgan, Matt Kaeberlein
Mitochondrial dysfunction can increase oxidative stress and extend lifespan in Caenorhabditis elegans. Homeostatic mechanisms exist to cope with disruptions to mitochondrial function that promote cellular health and organismal longevity. Previously, we determined that decreased expression of the cytosolic pentose phosphate pathway (PPP) enzyme transaldolase activates the mitochondrial unfolded protein response (UPRmt) and extends lifespan. Here we report that transaldolase (tald-1) deficiency impairs mitochondrial function in vivo, as evidenced by altered mitochondrial morphology, decreased respiration, and increased cellular H2O2 levels...
March 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28333301/preconception-maternal-lipoprotein-levels-in-relation-to-fecundability
#16
Sarah J Pugh, Enrique F Schisterman, Richard W Browne, Anne M Lynch, Sunni L Mumford, Neil J Perkins, Robert Silver, Lindsey Sjaarda, Joseph B Stanford, Jean Wactawski-Wende, Brian Wilcox, Katherine L Grantz
STUDY QUESTION: Are maternal preconception lipid levels associated with fecundability? SUMMARY ANSWER: Fecundability was reduced for all abnormal female lipid levels including total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and total triglyceride levels. WHAT IS KNOWN ALREADY: Subfecundity affects 7-15% of the population and lipid disorders are hypothesized to play a role since cholesterol acts as a substrate for the synthesis of steroid hormones...
May 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28329873/-incentive-for-regional-risk-selection-in-the-german-risk-structure-compensation-scheme
#17
Danny Wende
The introduction of the new law GKV-FQWG strengthens the competition between statutory health insurance. If incentives for risk selection exist, they may force a battle for cheap customers. This study aims to document and discuss incentives for regional risk selection in the German risk structure compensation scheme. Identify regional autocorrelation with Moran's l on financial parameters of the risk structure compensation schema. Incentives for regional risk selection do indeed exist. The risk structure compensation schema reduces 91% of the effect and helps to reduce risk selection...
March 22, 2017: Das Gesundheitswesen
https://www.readbyqxmd.com/read/28324062/gene-hormone-therapy-interaction-and-fracture-risk-in-postmenopausal-women
#18
Youjin Wang, Jean Wactawski-Wende, Lara E Sucheston-Campbell, Leah Preus, Kathleen M Hovey, Jing Nie, Rebecca D Jackson, Samuel K Handelman, Rami Nassir, Carolyn J Crandall, Heather M Ochs-Balcom
Context: Evidence supports a protective effect of menopausal hormone therapy (HT) on bone. However, whether genetic susceptibility modifies the association of HT and fracture risk is not sufficiently explored. Objective: The objective was to test an interaction between genetic susceptibility and HT on fracture risk. Design: We constructed two weighted genetic risk scores (GRSs) based on 16 fracture-associated variants (Fx-GRS) and 50 bone mineral density (BMD) variants (BMD-GRS)...
March 6, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28324031/sex-steroid-hormones-and-fracture-in-a-multiethnic-cohort-of-women-the-women-s-health-initiative-study-whi
#19
Jane A Cauley, Michelle E Danielson, Guru Rajesh Jammy, Doug C Bauer, Rebecca Jackson, Jean Wactawski-Wende, Rowan T Chlebowski, Kristine E Ensrud, Robert Boudreau
Context: We hypothesize that endogenous sex steroids are associated with fracture risk independent of race/ethnicity. Design and Setting: We performed a nested case-control study within the prospective Women's Health Initiative Observational Study. Incident nonspine fractures were identified in 381 black, 192 Hispanic, 112 Asian, and 46 Native American women over an average of 8.6 years. A random sample of 400 white women who experienced an incident fracture was chosen...
May 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28323989/preconception-low-dose-aspirin-restores-diminished-pregnancy-and-live-birth-rates-in-women-with-low-grade-inflammation-a-secondary-analysis-of-a-randomized-trial
#20
Lindsey A Sjaarda, Rose G Radin, Robert M Silver, Emily Mitchell, Sunni L Mumford, Brian Wilcox, Noya Galai, Neil J Perkins, Jean Wactawski-Wende, Joseph B Stanford, Enrique F Schisterman
Context: Inflammation is linked to causes of infertility. Low-dose aspirin (LDA) may improve reproductive success in women with chronic, low-grade inflammation. Objective: To investigate the effect of preconception-initiated LDA on pregnancy rate, pregnancy loss, live birth rate, and inflammation during pregnancy. Design: Stratified secondary analysis of a multicenter, block-randomized, double-blind, placebo-controlled trial. Setting: Four US academic medical centers, 2007 to 2012...
May 1, 2017: Journal of Clinical Endocrinology and Metabolism
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