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https://www.readbyqxmd.com/read/28074862/hypoxia-activates-wnt-%C3%AE-catenin-signaling-by-regulating-the-expression-of-bcl9-in-human-hepatocellular-carcinoma
#1
Wei Xu, Wang Zhou, Mo Cheng, Jing Wang, Zhian Liu, Shaohui He, Xiangji Luo, Wending Huang, Tianrui Chen, Wangjun Yan, Jianru Xiao
The Wnt/β-catenin signaling is abnormally activated in the progression of hepatocellular carcinoma (HCC). BCL9 is an essential co-activator in the Wnt/β-catenin signaling. Importantly, BCL9 is absent from tumors originating from normal cellular counterparts and overexpressed in many cancers including HCC. But the mechanism for BCL9 overexpression remains unknown. Ample evidence indicates that hypoxia inducible factors (HIFs) play a role in the development of HCC. It was found in our study that BCL9 was overexpressed in both primary HCC and bone metastasis specimens; loss of BCL9 inhibited the proliferation, migration and angiogenesis of HCC; and that that hypoxia mechanically induced the expression of BCL9...
January 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28039445/aromatase-inhibitor-induced-bone-loss-increases-the-progression-of-estrogen-receptor-negative-breast-cancer-in-bone-and-exacerbates-muscle-weakness-in-vivo
#2
Laura E Wright, Ahmed A Harhash, Wende M Kozlow, David L Waning, Jenna N Regan, Yun She, Sutha K John, Sreemala Murthy, Maryla Niewolna, Andrew R Marks, Khalid S Mohammad, Theresa A Guise
Aromatase inhibitors (AIs) cause muscle weakness, bone loss, and joint pain in up to half of cancer patients. Preclinical studies have demonstrated that increased osteoclastic bone resorption can impair muscle contractility and prime the bone microenvironment to accelerate metastatic growth. We hypothesized that AI-induced bone loss could increase breast cancer progression in bone and exacerbate muscle weakness associated with bone metastases. Female athymic nude mice underwent ovariectomy (OVX) or sham surgery and were treated with vehicle or AI (letrozole; Let)...
December 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/28019686/dietary-inflammatory-index-bone-mineral-density-and-risk-of-fracture-in-postmenopausal-women-results-from-the-women-s-health-initiative
#3
Tonya Orchard, Vedat Yildiz, Susan E Steck, James R Hébert, Yunsheng Ma, Jane A Cauley, Wenjun Li, Yasmin Mossavar-Rahmani, Karen C Johnson, Maryam Sattari, Meryl LeBoff, Jean Wactawski-Wende, Rebecca D Jackson
Previous studies suggest that bone loss and fracture risk are associated with higher inflammatory milieu, potentially modifiable by diet. The primary objective of this analysis was to evaluate the association of the dietary inflammatory index (DII(TM) ), a measure of the inflammatory potential of diet, with risk of hip, lower-arm and total fracture using longitudinal data from the Women's Health Initiative Observational Study and Clinical Trials. Secondarily, we evaluated changes in bone mineral density (BMD) and DII scores...
December 26, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28007567/global-phylogeography-of-oithona-similis-s-l-crustacea-copepoda-oithonidae-a-cosmopolitan-plankton-species-or-a-complex-of-cryptic-lineages
#4
Astrid Cornils, Britta Wend-Heckmann, Christoph Held
Traditionally, many small-sized copepod species are considered to be widespread, bipolar or cosmopolitan. However, these large-scale distribution patterns need to be re-examined in view of increasing evidence of cryptic and pseudo-cryptic speciation in pelagic copepods. Here, we present a phylogeographic study of Oithona similis s.l. populations from the Arctic Ocean, the Southern Ocean and its northern boundaries, the North Atlantic and the Mediterrranean Sea. O. similis s.l. is considered as one of the most abundant species in temperate to polar oceans and acts as an important link in the trophic network between the microbial loop and higher trophic levels such as fish larvae...
December 19, 2016: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/27989460/touch-receptor-derived-sensory-information-alleviates-acute-pain-signaling-and-fine-tunes-nociceptive-reflex-coordination
#5
Alice Arcourt, Louise Gorham, Rahul Dhandapani, Vincenzo Prato, Francisco J Taberner, Hagen Wende, Vijayan Gangadharan, Carmen Birchmeier, Paul A Heppenstall, Stefan G Lechner
Painful mechanical stimuli activate multiple peripheral sensory afferent subtypes simultaneously, including nociceptors and low-threshold mechanoreceptors (LTMRs). Using an optogenetic approach, we demonstrate that LTMRs do not solely serve as touch receptors but also play an important role in acute pain signaling. We show that selective activation of neuropeptide Y receptor-2-expressing (Npy2r) myelinated A-fiber nociceptors evokes abnormally exacerbated pain, which is alleviated by concurrent activation of LTMRs in a frequency-dependent manner...
January 4, 2017: Neuron
https://www.readbyqxmd.com/read/27987864/1d-nmr-methods-for-determination-of-degree-of-cross-linking-and-bdde-substitution-positions-in-ha-hydrogels
#6
Frida J Wende, Suresh Gohil, Lars I Nord, Anne Helander Kenne, Corine Sandström
Hyaluronic acid polymers cross-linked with BDDE are today among the most used hydrogels for biomedical applications. The physical properties of the hydrogels depend, among other parameters, on the degree of cross-linking of HA. Another parameter likely to affect the physical properties is the substitution position of the linker on the HA functional groups. A NMR-based method for the determination of these parameters in hyaluronic acid hydrogels is presented. The method is based on the degradation of HA cross linked hydrogels by chondroitinase ABC followed by one-dimensional (1)H and (13)C NMR analysis...
February 10, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27965573/7-8-dihydroxyflavone-ameliorates-cognitive-impairment-by-inhibiting-expression-of-tau-pathology-in-apoe-knockout-mice
#7
Yang Tan, Shuke Nie, Wende Zhu, Fang Liu, Hailong Guo, Jiewen Chu, Xue B Cao, Xingjun Jiang, Yunjian Zhang, Yuzhen Li
7,8-Dihydroxyflavone (7,8-DHF), a tyrosine kinase B agonist that mimics the neuroprotective properties of brain-derived neurotrophic factor, which can not efficiently deliver into the brain, has been reported to be useful in ameliorating cognitive impairment in many diseases. Researches have indicated that apolipoprotein E-knockout (ApoE-KO) mouse was associated with cognitive alteration via various mechanisms. Our present study investigated the possible mechanisms of cognitive impairment of ApoE-KO mouse fed with western type diet and the protective effects of 7,8-DHF in improving spatial learning and memory in ApoE-KO mouse...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27934055/sub-10-fs-time-resolved-vibronic-optical-microscopy
#8
Christoph Schnedermann, Jong Min Lim, Torsten Wende, Alex S Duarte, Limeng Ni, Qifei Gu, Aditya Sadhanala, Akshay Rao, Philipp Kukura
We introduce femtosecond wide-field transient absorption microscopy combining sub-10 fs pump and probe pulses covering the complete visible (500-650 nm) and near-infrared (650-950 nm) spectrum with diffraction-limited optical resolution. We demonstrate the capabilities of our system by reporting the spatially- and spectrally-resolved transient electronic response of MAPbI3-xClx perovskite films and reveal significant quenching of the transient bleach signal at grain boundaries. The unprecedented temporal resolution enables us to directly observe the formation of band-gap renormalization, completed in 25 fs after photoexcitation...
December 1, 2016: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/27932054/changes-in-physical-activity-sedentary-time-and-risk-of-falling-the-women-s-health-initiative-observational-study
#9
Jennifer W Bea, Cynthia A Thomson, Robert B Wallace, Chunyuan Wu, Rebecca A Seguin, Scott B Going, Andrea LaCroix, Charles Eaton, Judith K Ockene, Michael J LaMonte, Rebecca Jackson, W Jerry Mysiw, Jean Wactawski-Wende
Falling significantly affects quality of life, morbidity, and mortality among older adults. We sought to evaluate the prospective association between sedentary time, physical activity, and falling among post-menopausal women aged 50-79years recruited to the Women's Health Initiative Observational Study between 1993 and 1998 from 40 clinical centers across the United States. Baseline (B) and change in each of the following were evaluated at year 3 (Y3) and year 6 (Y6; baseline n=93,676; Y3 n=76,598; Y6 n=75,428): recreational physical activity (MET-h/wk), sitting, sleeping (min/day), and lean body mass by dual energy X-ray absorptiometry (subset N=6475)...
December 6, 2016: Preventive Medicine
https://www.readbyqxmd.com/read/27900430/visible-and-red-emissive-molecular-beacons-for-optical-temperature-measurements-and-quality-control-in-diagnostic-assays-utilizing-temperature-dependent-amplification-reactions
#10
Zerrin Fidan, Andy Wende, Ute Resch-Genger
Quality control requirements imposed on assays used in clinical diagnostics and point-of-care-diagnostic testing (POCT), utilizing amplification reactions performed at elevated temperatures of 35 to 95 °C are very stringent. As the temperature of a reaction vessel has a large impact on the specificity and sensitivity of the amplification reaction, simple tools for local in situ temperature sensing and monitoring are required for reaction and assay control. We describe here a platform of stem-and-loop structured DNA hairpins (molecular beacons, MBs), absorbing and emitting in the visible and red spectral region, rationally designed for precise temperature measurements in microfluidic assays for POCT, and their application for temperature measurements in a common DNA-based molecular biological assay utilizing thermophilic helicase-dependent amplification (tHDA)...
November 29, 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27881593/dairy-food-intake-is-associated-with-reproductive-hormones-and-sporadic-anovulation-among-healthy-premenopausal-women
#11
Keewan Kim, Jean Wactawski-Wende, Kara A Michels, Torie C Plowden, Ellen N Chaljub, Lindsey A Sjaarda, Sunni L Mumford
BACKGROUND: Dairy food intake has been associated with infertility; however, little is known with regard to associations with reproductive hormones or anovulation. OBJECTIVE: We investigated whether intakes of dairy foods and specific nutrients were associated with reproductive hormone concentrations across the cycle and the risk of sporadic anovulation among healthy women. METHODS: We prospectively measured serum reproductive hormones ≤8 times/menstrual cycle for 2 cycles from 259 regularly menstruating women (mean age: 27...
November 23, 2016: Journal of Nutrition
https://www.readbyqxmd.com/read/27879043/uncovering-key-structural-features-of-an-enantioselective-peptide-catalyzed-acylation-utilizing-advanced-nmr-techniques
#12
Eliška Procházková, Andreas Kolmer, Julian Ilgen, Mira Schwab, Lukas Kaltschnee, Maic Fredersdorf, Volker Schmidts, Raffael C Wende, Peter R Schreiner, Christina M Thiele
We report on a detailed NMR spectroscopic study of the catalyst-substrate interaction of a highly enantioselective oligopeptide catalyst that is used for the kinetic resolution of trans-cycloalkane-1,2-diols via monoacylation. The extraordinary selectivity has been rationalized by molecular dynamics as well as density functional theory (DFT) computations. Herein we describe the conformational analysis of the organocatalyst studied by a combination of nuclear Overhauser effect (NOE) and residual dipolar coupling (RDC)-based methods that resulted in an ensemble of four final conformers...
December 19, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27872138/micrornas-103-107-coordinately-regulate-macropinocytosis-and-autophagy
#13
Jong Kook Park, Han Peng, Julia Katsnelson, Wending Yang, Nihal Kaplan, Ying Dong, Joshua Z Rappoport, CongCong He, Robert M Lavker
Macropinocytosis, by which cells ingest large amounts of fluid, and autophagy, the lysosome-based catabolic process, involve vesicular biogenesis (early stage) and turnover (end stage). Much is known about early-stage events; however, our understanding of how the end stages of these processes are governed is incomplete. Here we demonstrate that the microRNA-103/107(miR-103/107) family, which is preferentially expressed in the stem cell-enriched limbal epithelium, coordinately regulates aspects of both these activities...
December 5, 2016: Journal of Cell Biology
https://www.readbyqxmd.com/read/27846573/a-pathogenic-role-for-t-cell-derived-il-22bp-in-inflammatory-bowel-disease
#14
Penelope Pelczar, Mario Witkowski, Laura Garcia Perez, Jan Kempski, Anna G Hammel, Leonie Brockmann, Dörte Kleinschmidt, Sandra Wende, Cathleen Haueis, Tanja Bedke, Marco Witkowski, Susanne Krasemann, Stefan Steurer, Carmen J Booth, Philipp Busch, Alexandra König, Ursula Rauch, Daniel Benten, Jakob R Izbicki, Thomas Rösch, Ansgar W Lohse, Till Strowig, Nicola Gagliani, Richard A Flavell, Samuel Huber
Intestinal inflammation can impair mucosal healing, thereby establishing a vicious cycle leading to chronic inflammatory bowel disease (IBD). However, the signaling networks driving chronic inflammation remain unclear. Here we report that CD4(+) T cells isolated from patients with IBD produce high levels of interleukin-22 binding protein (IL-22BP), the endogenous inhibitor of the tissue-protective cytokine IL-22. Using mouse models, we demonstrate that IBD development requires T cell-derived IL-22BP. Lastly, intestinal CD4(+) T cells isolated from IBD patients responsive to treatment with antibodies against tumor necrosis factor-α (anti-TNF-α), the most effective known IBD therapy, exhibited reduced amounts of IL-22BP expression but still expressed IL-22...
October 21, 2016: Science
https://www.readbyqxmd.com/read/27846053/inaccurate-self-report-of-height-and-its-impact-on-misclassification-of-body-mass-index-in-postmenopausal-women
#15
Xiaodan Mai, Jill N Sperrazza, Britt A Marshall, Kathleen M Hovey, Jean Wactawski-Wende
OBJECTIVE: Self-reported height is commonly used in population obesity research. Evidence has also shown a positive association between depression and obesity. We examined the extent of height misreporting and its impact on body mass index (BMI) calculations and classification, and explored whether depression is associated with height misreporting. METHODS: The Buffalo Osteoporosis and Periodontal Disease Follow-up Study enrolled 1,015 postmenopausal women between 2002 and 2006...
November 14, 2016: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/27828315/wide-band-dispersionless-slow-light-in-hetero-mim-plasmonic-waveguide
#16
Dacheng Li, Kang Du, Shuhai Liang, Wending Zhang, Ting Mei
A flat slow-light band over a wide frequency range is obtained in the hetero-MIM (metal-insulator-metal) waveguide with zero group velocity dispersion (GVD). The zero GVD originates from dispersion compensation by the photonic mode and the plasmonic mode, the mechanism of which does not exist in the homo-MIM structure. By changing dielectric permittivity of the insulator or the difference of two different metallic plasma frequencies, the group index and the bandwidth can be tuned. The dispersionless slow light characteristic in the hetero-MIM waveguide may be useful in the new design of plasmonic devices...
October 3, 2016: Optics Express
https://www.readbyqxmd.com/read/27825105/mir-184-exhibits-angiostatic-properties-via-regulation-of-akt-and-vegf-signaling-pathways
#17
Jong Kook Park, Han Peng, Wending Yang, Julia Katsnelson, Olga Volpert, Robert M Lavker
Corneal avascularity is critical for achieving transparency necessary for proper transmission of light to the lens and visual acuity. Although much is known about angiogenesis and angiostasis, the precise regulation of these processes in the cornea is unclear. MicroRNA (miR)-184, the most abundant corneal epithelial miRNA, has been suggested to function in corneal angiostasis by altering VEGF signaling; however, the mechanism(s) underlying this regulation have not been addressed. Using a combination of in vitro and in vivo assays to evaluate angiogenesis, we demonstrated that human limbal epithelial keratinocytes (HLEKs) engineered to overexpress miR-184 secreted lower amounts of angiogenic mitogens...
January 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/27821202/food-composition-tables-in-resource-poor-settings-exploring-current-limitations-and-opportunities-with-a-focus-on-animal-source-foods-in-sub-saharan-africa
#18
Julia de Bruyn, Elaine Ferguson, Margaret Allman-Farinelli, Ian Darnton-Hill, Wende Maulaga, John Msuya, Robyn Alders
Animal-source foods (ASF) have the potential to enhance the nutritional adequacy of cereal-based diets in low- and middle-income countries, through the provision of high-quality protein and bioavailable micronutrients. The development of guidelines for including ASF in local diets requires an understanding of the nutrient content of available resources. This article reviews food composition tables (FCT) used in sub-Saharan Africa, examining the spectrum of ASF reported and exploring data sources for each reference...
November 8, 2016: British Journal of Nutrition
https://www.readbyqxmd.com/read/27820659/no-increase-in-fractures-after-stopping-hormone-therapy-results-from-the-women-s-health-initiative
#19
Nelson B Watts, Jane A Cauley, Rebecca D Jackson, Andrea Z LaCroix, Cora E Lewis, JoAnn E Manson, Joan Neuner, Lawrence S Phillips, Marcia L Stefanick, Jean Wactawski-Wende, Carolyn Crandall
CONTEXT: The Women's Health Initiative (WHI) hormone therapy (HT) trials showed protection against hip and total fractures but a later observational report suggested loss of benefit and a rebound increased risk after stopping. OBJECTIVE: To examine fractures after discontinuation of HT Design and Setting: Two placebo-controlled randomized trials Patients: 15,187 WHI participants who continued active HT or placebo through the intervention period and did not take HT in the post-intervention period Interventions: Conjugated equine estrogen + medroxyprogesterone acetate (CEE+MPA) in naturally menopausal women and conjugated equine estrogen (CEE) alone in women with prior hysterectomy Main Outcome Measures: Total and hip fractures through 5 years after discontinuation Results: Hip fractures were infrequent (∼2...
November 7, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27805691/high-order-optical-vortex-generation-in-a-few-mode-fiber-via-cascaded-acoustically-driven-vector-mode-conversion
#20
Wending Zhang, Ligang Huang, Keyan Wei, Peng Li, Biqiang Jiang, Dong Mao, Feng Gao, Ting Mei, Guoquan Zhang, Jianlin Zhao
We propose a method to generate the high-order optical vortex in a few-mode fiber via cascaded acoustically driven vector mode conversion. Theoretical analysis showed that the vector mode conversion induced by the acoustically induced fiber grating (AIFG) could occur between two HE modes with adjacent azimuthal numbers. In the experiment conducted at 532 nm, two AIFGs were simultaneously induced in the same segment of the fiber by a radio frequency source containing two different frequency components. One AIFG was used to convert the left- and right-handed circular polarization fundamental modes to the ±1-order vortex modes, which were then further converted to the ±2-order vortex modes by the other AIFG...
November 1, 2016: Optics Letters
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