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https://www.readbyqxmd.com/read/29769633/chemical-fingerprints-of-cold-physical-plasmas-an-experimental-and-computational-study-using-cysteine-as-tracer-compound
#1
J-W Lackmann, K Wende, C Verlackt, J Golda, J Volzke, F Kogelheide, J Held, S Bekeschus, A Bogaerts, V Schulz-von der Gathen, K Stapelmann
Reactive oxygen and nitrogen species released by cold physical plasma are being proposed as effectors in various clinical conditions connected to inflammatory processes. As these plasmas can be tailored in a wide range, models to compare and control their biochemical footprint are desired to infer on the molecular mechanisms underlying the observed effects and to enable the discrimination between different plasma sources. Here, an improved model to trace short-lived reactive species is presented. Using FTIR, high-resolution mass spectrometry, and molecular dynamics computational simulation, covalent modifications of cysteine treated with different plasmas were deciphered and the respective product pattern used to generate a fingerprint of each plasma source...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29767694/shorter-time-to-pregnancy-with-increasing-preconception-carotene-concentrations-among-women-with-1-to-2-previous-pregnancy-losses
#2
Keewan Kim, Enrique F Schisterman, Robert M Silver, Brian D Wilcox, Anne M Lynch, Neil J Perkins, Richard W Browne, Laurie L Lesher, Joseph B Stanford, Aijun Ye, Jean Wactawski-Wende, Sunni L Mumford
Although maternal nutrition may impact fecundity, associations between preconception micronutrients and time to pregnancy (TTP) has not been examined. We assessed the relationship between preconception fat-soluble micronutrient concentrations and TTP among women with 1-2 prior pregnancy losses. This is a prospective cohort study of 1,228 women set in the EAGeR Trial (US, 2007-2011), which assessed the effect of preconception-initiated daily low dose aspirin on reproductive outcomes. We measured preconception zeaxanthin, cryptoxanthin, lycopene, α- and β-carotene, and α- and γ-tocopherol in serum...
May 14, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29762199/physical-activity-modifies-genetic-susceptibility-to-obesity-in-postmenopausal-women
#3
Heather M Ochs-Balcom, Leah Preus, Jing Nie, Jean Wactawski-Wende, Linda Agyemang, Marian L Neuhouser, Lesley Tinker, Cheng Zheng, Rasa Kazlauskaite, Lihong Qi, Lara E Sucheston-Campbell
OBJECTIVE: We conducted a gene-environment interaction study to evaluate whether the association of body mass index (BMI) associated meta genome-wide association study single-nucleotide polymorphisms (SNPs) (as a genetic risk score) and BMI is modified by physical activity and age. METHODS: In 8,206 women of European ancestry from the Women's Health Initiative (WHI), we used linear regression to examine main effects of the 95 SNP BMI genetic risk score (GRS) and physical activity on BMI, and evaluated whether genetic associations are modified by physical activity (two-way interaction) and age (three-way interaction)...
May 14, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29748249/maf-links-neuregulin1-signaling-to-cholesterol-synthesis-in-myelinating-schwann-cells
#4
Minchul Kim, Hagen Wende, Jan Walcher, Johannes Küehnemund, Cyril Cheret, Stefan Kempa, Erik McShane, Matthias Selbach, Gary R Lewin, Carmen Birchmeier
Cholesterol is a major constituent of myelin membranes, which insulate axons and allow saltatory conduction. Therefore, Schwann cells, the myelinating glia of the peripheral nervous system, need to produce large amounts of cholesterol. Here, we define a crucial role of the transcription factor Maf in myelination and cholesterol biosynthesis and show that Maf acts downstream from Neuregulin1 (Nrg1). Maf expression is induced when Schwann cells begin myelination. Genetic ablation of Maf resulted in hypomyelination that resembled mice with defective Nrg1 signaling...
May 10, 2018: Genes & Development
https://www.readbyqxmd.com/read/29743121/high-frequency-oscillatory-ventilation-guided-by-transpulmonary-pressure-in-acute-respiratory-syndrome-an-experimental-study-in-pigs
#5
Philipp Klapsing, Onnen Moerer, Christoph Wende, Peter Herrmann, Michael Quintel, Annalen Bleckmann, Jan Florian Heuer
BACKGROUND: Recent clinical studies have not shown an overall benefit of high-frequency oscillatory ventilation (HFOV), possibly due to injurious or non-individualized HFOV settings. We compared conventional HFOV (HFOVcon ) settings with HFOV settings based on mean transpulmonary pressures (PLmean ) in an animal model of experimental acute respiratory distress syndrome (ARDS). METHODS: ARDS was induced in eight pigs by intrabronchial installation of hydrochloric acid (0...
May 9, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29738411/risk-factors-for-5-year-prospective-height-loss-among-postmenopausal-women
#6
Xiaodan Mai, Britt Marshall, Kathleen M Hovey, Jill Sperrazza, Jean Wactawski-Wende
OBJECTIVE: Height loss is common in older women and has been associated with increased morbidity and mortality. In this study, we identified factors that could predict prospective height loss in postmenopausal women. METHODS: Height was measured in 1,024 postmenopausal women, enrolled in the Buffalo Osteoporosis and Periodontal Disease Study, at baseline and 5 years later using a fixed stadiometer. Demographics, lifestyle, medical history, and medication use were assessed at baseline...
May 7, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29732979/cold-physical-plasma-treated-buffered-saline-solution-as-effective-agent-against-pancreatic-cancer-cells
#7
Sander Bekeschus, Andre Kading, Tim Schroder, Kristian Wende, Christine Hackbarth, Kim Rouven Liedtke, Julia van der Linde, Thomas von Woedtke, Claus-Dieter Heidecke, Lars-Ivo Partecke
Cold physical plasma has been suggested as a new anticancer tool recently. However, direct use of plasma is limited to visible tumors and in some clinical situations not feasible. This includes repetitive treatment of peritoneal metastases which commonly occur in advanced gastrointestinal cancer and in pancreatic cancer in particular. In case of diffuse intraperitoneal metastatic spread Hyperthermic Intraperitoneal Intraoperative Chemotherapy (HIPEC) is used as therapeutic approach. Plasma treated solutions may combine their suspected systemic non-toxic characteristics with the anticancer effects of HIPEC...
May 7, 2018: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29731256/antiretroviral-therapy-potentiates-high-fat-diet-induced-obesity-and-glucose-intolerance
#8
Mark E Pepin, Lindsey E Padgett, Ruth E McDowell, Ashley R Burg, Manoja K Brahma, Cassie Holleman, Teayoun Kim, David Crossman, Olaf Kutsch, Hubert M Tse, Adam R Wende, Kirk M Habegger
OBJECTIVE: Breakthroughs in HIV treatment, especially combination antiretroviral therapy (ART), have massively reduced AIDS-associated mortality. However, ART administration amplifies the risk of non-AIDS defining illnesses including obesity, diabetes, and cardiovascular disease, collectively known as metabolic syndrome. Initial reports suggest that ART-associated risk of metabolic syndrome correlates with socioeconomic status, a multifaceted finding that encompasses income, race, education, and diet...
April 20, 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/29673411/dietary-minerals-reproductive-hormone-levels-and-sporadic-anovulation-associations-in-healthy-women-with-regular-menstrual-cycles
#9
Keewan Kim, Jean Wactawski-Wende, Kara A Michels, Karen C Schliep, Torie C Plowden, Ellen N Chaljub, Sunni L Mumford
Although minerals are linked to several reproductive outcomes, it is unknown whether dietary minerals are associated with ovulatory function. We hypothesised that low intakes of minerals would be associated with an increased risk of anovulation. We investigated associations between dietary mineral intake and both reproductive hormones and anovulation in healthy women in the BioCycle Study, which prospectively followed up 259 regularly menstruating women aged 18-44 years who were not taking mineral supplements for two menstrual cycles...
April 20, 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29662170/c-maf-controls-immune-responses-by-regulating-disease-specific-gene-networks-and-repressing-il-2-in-cd4-t-cells
#10
Leona Gabryšová, Marisol Alvarez-Martinez, Raphaëlle Luisier, Luke S Cox, Jan Sodenkamp, Caroline Hosking, Damián Pérez-Mazliah, Charlotte Whicher, Yashaswini Kannan, Krzysztof Potempa, Xuemei Wu, Leena Bhaw, Hagen Wende, Michael H Sieweke, Greg Elgar, Mark Wilson, James Briscoe, Vicki Metzis, Jean Langhorne, Nicholas M Luscombe, Anne O'Garra
The transcription factor c-Maf induces the anti-inflammatory cytokine IL-10 in CD4+ T cells in vitro. However, the global effects of c-Maf on diverse immune responses in vivo are unknown. Here we found that c-Maf regulated IL-10 production in CD4+ T cells in disease models involving the TH 1 subset of helper T cells (malaria), TH 2 cells (allergy) and TH 17 cells (autoimmunity) in vivo. Although mice with c-Maf deficiency targeted to T cells showed greater pathology in TH 1 and TH 2 responses, TH 17 cell-mediated pathology was reduced in this context, with an accompanying decrease in TH 17 cells and increase in Foxp3+ regulatory T cells...
April 16, 2018: Nature Immunology
https://www.readbyqxmd.com/read/29617712/oral-bisphosphonate-use-and-lung-cancer-incidence-among-postmenopausal-women
#11
M H Tao, S Chen, J L Freudenheim, J A Cauley, K C Johnson, X Mai, G E Sarto, H Wakelee, P Boffetta, J Wactawski-Wende
Background: Bisphosphonates are common medications for the treatment of osteoporosis in older populations. Several studies, including the Women's Health Initiative (WHI), have found inverse associations of bisphosphonate use with risk of breast and endometrial cancer, but little is known about its association with other common malignancies. The objective of this study was to evaluate the association of bisphosphonate use on the incidence of lung cancer in the WHI. Patients and methods: The association between oral bisphosphonate use and lung cancer risk was examined in 151,432 postmenopausal women enrolled into the WHI in 1993-1998...
March 29, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29601037/all-fiber-radially-azimuthally-polarized-lasers-based-on-mode-coupling-of-tapered-fibers
#12
Dong Mao, Zhiwen He, Hua Lu, Mingkun Li, Wending Zhang, Xiaoqi Cui, Biqiang Jiang, Jianlin Zhao
We demonstrate a mode converter with an insertion loss of 0.36 dB based on mode coupling of tapered single-mode and two-mode fibers, and realize all-fiber flexible cylindrical vector lasers at 1550 nm. Attributing to the continuous distribution of a tangential electric field at taper boundaries, the laser is switchable between the radially and azimuthally polarized states by adjusting the input polarization. In the temporal domain, the operation is controllable among continuous-wave, Q-switched, and mode-locked statuses by changing the saturable absorber or pump strength...
April 1, 2018: Optics Letters
https://www.readbyqxmd.com/read/29576481/the-monocot-specific-receptor-like-kinase-sds2-controls-cell-death-and-immunity-in-rice
#13
Jiangbo Fan, Pengfei Bai, Yuese Ning, Jiyang Wang, Xuetao Shi, Yehui Xiong, Kai Zhang, Feng He, Chongyang Zhang, Ruyi Wang, Xiangzong Meng, Jinggeng Zhou, Mo Wang, Gautam Shirsekar, Chan Ho Park, Maria Bellizzi, Wende Liu, Jong-Seong Jeon, Ye Xia, Libo Shan, Guo-Liang Wang
Programmed cell death (PCD) plays critical roles in plant immunity but must be regulated to prevent excessive damage. The E3 ubiquitin ligase SPL11 negatively regulates PCD and immunity in plants. We show that SPL11 cell-death suppressor 2 (SDS2), an S-domain receptor-like kinase, positively regulates PCD and immunity in rice by engaging and regulating SPL11 and related kinases controlling defense responses. An sds2 mutant shows reduced immune responses and enhanced susceptibility to the blast fungus Magnaporthe oryzae...
March 20, 2018: Cell Host & Microbe
https://www.readbyqxmd.com/read/29539430/data-driven-modeling-of-intracellular-auxin-fluxes-indicates-a-dominant-role-of-the-er-in-controlling-nuclear-auxin-uptake
#14
Alistair M Middleton, Cristina Dal Bosco, Phillip Chlap, Robert Bensch, Hartmann Harz, Fugang Ren, Stefan Bergmann, Sabrina Wend, Wilfried Weber, Ken-Ichiro Hayashi, Matias D Zurbriggen, Rainer Uhl, Olaf Ronneberger, Klaus Palme, Christian Fleck, Alexander Dovzhenko
In plants, the phytohormone auxin acts as a master regulator of developmental processes and environmental responses. The best characterized process in the auxin regulatory network occurs at the subcellular scale, wherein auxin mediates signal transduction into transcriptional programs by triggering the degradation of Aux/IAA transcriptional repressor proteins in the nucleus. However, whether and how auxin movement between the nucleus and the surrounding compartments is regulated remain elusive. Using a fluorescent auxin analog, we show that its diffusion into the nucleus is restricted...
March 13, 2018: Cell Reports
https://www.readbyqxmd.com/read/29535422/the-her4-yap1-axis-promotes-trastuzumab-resistance-in-her2-positive-gastric-cancer-by-inducing-epithelial-and-mesenchymal-transition
#15
Jiaolong Shi, Fengping Li, Xingxing Yao, Tingyu Mou, Zhijun Xu, Zheng Han, Siyu Chen, Wende Li, Jiang Yu, Xiaolong Qi, Hao Liu, Guoxin Li
Trastuzumab is the only target to be approved as the first-line treatment of HER2 positive metastatic gastric cancer, but ubiquitous resistance decreases its therapeutic benefit. In this study, we found HER4, phosphorylation HER4 (p-HER4) and the mesenchymal marker Vimentin increased in trastuzumab-resistant cells (MKN45TR and NCI-N87TR), while epithelial markers expressions in trastuzumab-resistant cell lines and animal models decreased. Additionally, silencing HER4 prevented the epithelial-mesenchymal transition and led to decreased proliferation and migration in vitro and in vivo...
March 14, 2018: Oncogene
https://www.readbyqxmd.com/read/29526753/mfap5-promotes-tumor-progression-and-bone-metastasis-by-regulating-erk-mmp-signaling-pathways-in-breast-cancer
#16
Zhiqiang Wu, Ting Wang, Meng Fang, Wending Huang, Zhengwang Sun, Jianru Xiao, Wangjun Yan
Breast cancer accounts for about 30% of all cancers in women, while approximately 70% breast cancer patients developed bone metastases throughout the course of their disease, highlighting the importance of exploring new therapeutic targets. Microfibrillar-associated protein 5 (MFAP5) is a component of extracellular elastic microfibril which has been confirmed to function in tissue development and cancer progression. But the role of MFAP5 in breast cancer remains unclear. The present study demonstrated that MFAP5 was up-regulated in breast cancers compared with that in normal breast tissues, and further increased in breast cancer bone metastasis...
April 6, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29520041/tobacco-alcohol-use-and-risk-of-hepatocellular-carcinoma-and-intrahepatic-cholangiocarcinoma-the-liver-cancer-pooling-project
#17
Jessica L Petrick, Peter T Campbell, Jill Koshiol, Jake E Thistle, Gabriella Andreotti, Laura E Beane-Freeman, Julie E Buring, Andrew T Chan, Dawn Q Chong, Michele M Doody, Susan M Gapstur, John Michael Gaziano, Edward Giovannucci, Barry I Graubard, I-Min Lee, Linda M Liao, Martha S Linet, Julie R Palmer, Jenny N Poynter, Mark P Purdue, Kim Robien, Lynn Rosenberg, Catherine Schairer, Howard D Sesso, Rashmi Sinha, Meir J Stampfer, Marcia Stefanick, Jean Wactawski-Wende, Xuehong Zhang, Anne Zeleniuch-Jacquotte, Neal D Freedman, Katherine A McGlynn
BACKGROUND: While tobacco and alcohol are established risk factors for hepatocellular carcinoma (HCC), the most common type of primary liver cancer, it is unknown whether they also increase the risk of intrahepatic cholangiocarcinoma (ICC). Thus, we examined the association between tobacco and alcohol use by primary liver cancer type. METHODS: The Liver Cancer Pooling Project is a consortium of 14 US-based prospective cohort studies that includes data from 1,518,741 individuals (HCC n = 1423, ICC n = 410)...
April 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29518953/a-neutrophil-proteomic-signature-in-surgical-trauma-wounds
#18
Sander Bekeschus, Jan-Wilm Lackmann, Denis Gümbel, Matthias Napp, Anke Schmidt, Kristian Wende
Non-healing wounds continue to be a clinical challenge for patients and medical staff. These wounds have a heterogeneous etiology, including diabetes and surgical trauma wounds. It is therefore important to decipher molecular signatures that reflect the macroscopic process of wound healing. To this end, we collected wound sponge dressings routinely used in vacuum assisted therapy after surgical trauma to generate wound-derived protein profiles via global mass spectrometry. We confidently identified 311 proteins in exudates...
March 7, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29499003/the-impact-of-stroke-nurse-navigation-on-patient-compliance-postdischarge
#19
Tonya Deen, Theresa Terna, Elizabeth Kim, Brian Leahy, Wende Fedder
PURPOSE: The purpose of this study was to describe the impact a stroke nurse navigation program has on concurrent chart reviews and patient compliance postdischarge. DESIGN: Phase I: Concurrent chart review of The Joint Commission Primary Stroke Center core measures for ischemic stroke patients. Phase II: Longitudinal study of 100 ischemic stroke patients discharged to home. METHODS: Telephone surveys were conducted at prescribed intervals posthospital discharge (Phase II)...
March 2018: Rehabilitation Nursing: the Official Journal of the Association of Rehabilitation Nurses
https://www.readbyqxmd.com/read/29485408/surface-enhanced-raman-spectroscopy-with-au-nanoparticle-substrate-fabricated-by-using-femtosecond-pulse
#20
Wending Zhang, Cheng Li, Kun Gao, Fanfan Lu, Min Liu, Xin Li, Lu Zhang, Dong Mao, Feng Gao, Ligang Huang, Ting Mei, Jianlin Zhao
Au-nanoparticle (Au-NP) substrates for surface-enhanced Raman spectroscopy (SERS) were fabricated by grid-like scanning a Au-film using a femtosecond pulse. The Au-NPs were directly deposited on the Au-film surface due to the scanning process. The experimentally obtained Au-NPs presented local surface plasmon resonance effect in the visible spectral range, as verified by finite difference time domain simulations and measured reflection spectrum. The SERS experiment using the Au-NP substrates exhibited high activity and excellent substrate reproducibility and stability, and a clearly present Raman spectra of target analytes, e...
May 18, 2018: Nanotechnology
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