keyword
https://read.qxmd.com/read/37869901/diabetes-antidiabetic-medications-and-risk-of-dementia-a-systematic-umbrella-review-and-meta-analysis
#1
REVIEW
Alvin Kuate Defo, Veselko Bakula, Alessandro Pisaturo, Christopher Labos, Simon S Wing, Stella S Daskalopoulou
AIMS: The objective of this umbrella review and meta-analysis was to evaluate the effect of diabetes on risk of dementia, as well as the mitigating effect of antidiabetic treatments. MATERIALS AND METHODS: We conducted a systematic umbrella review on diabetes and its treatment, and a meta-analysis focusing on treatment. We searched MEDLINE/PubMed, Embase, PsycINFO, CINAHL and the Cochrane Library for systematic reviews and meta-analyses assessing the risk of cognitive decline/dementia in individuals with diabetes until 2 July 2023...
February 2024: Diabetes, Obesity & Metabolism
https://read.qxmd.com/read/36340488/synchronizing-systolic-calcium-release-with-azumolene-in-an-experimental-model
#2
JOURNAL ARTICLE
Daoyuan Si, Praloy Chakraborty, Mohammed Ali Azam, Madhav Krishna Kumar Nair, Stéphane Massé, Patrick F H Lai, Christopher Labos, Sheila Riazi, Kumaraswamy Nanthakumar
Background: Post-defibrillation myocardial contractile dysfunction adversely affects the survival of patients after cardiac arrest. Attenuation of diastolic calcium (Ca2+ ) overload by stabilization of the cardiac ryanodine receptor (RyR2) is found to reduce refibrillation after long-duration ventricular fibrillation (LDVF). Objective: In the present study, we explored the effects of RyR2 stabilization by azumolene on systolic Ca2+ release synchrony and myocardial contractility...
October 2022: Heart rhythm O2
https://read.qxmd.com/read/35118371/arterial-stiffness-measurements-in-pregnancy-as-a-predictive-tool-for-hypertensive-disorders-of-pregnancy-and-preeclampsia-protocol-for-a-systematic-review-and-meta-analysis
#3
JOURNAL ARTICLE
Mekayla Forrest, Sophia Bourgeois, Émilie Pichette, Sarah Caughlin, Alvin Kuate Defo, Lindsay Hales, Christopher Labos, Stella S Daskalopoulou
Hypertensive disorders of pregnancy (HDPs) are a leading cause of maternal morbidity and mortality worldwide. Unfortunately, accurate early clinical screening methods for the development of these disorders are lacking. Arterial stiffness (AS) is an important hemodynamic indicator of vascular health that has shown promising results for the prediction of HDP onset. Past systematic reviews in the field have reported an increase in AS indices in women who develop HDPs and have highlighted the potential of AS measurements as a predictive tool early in pregnancy...
January 2022: European journal of obstetrics & gynecology and reproductive biology: X
https://read.qxmd.com/read/34987917/chronic-pediatric-pain-and-mental-illness-during-the-covid-19-era-a-case-series-from-inpatient-child-psychiatry-unit
#4
Ankit Jain, Sage Gee, Srikrishna V Malayala, Christopher W Laboe
Chronic pain is defined as pain that persists following tissue injury or disease processes and is believed to have taken place after healing. It is a functional impairment that causes discomfort and leads to the inability to perform various essential daily activities. Chronic pain in pediatrics can be of various types, the most commonly prevalent types being headaches, abdominal pain, and limb pain. Adolescents with chronic pain have been found to have generalized anxiety scores twice that of the average population, along with significant impairment of family dynamics...
November 2021: Curēus
https://read.qxmd.com/read/34900487/physician-suicide-in-the-era-of-the-covid-19-pandemic
#5
EDITORIAL
Christopher W Laboe, Ankit Jain, Krishna Priya Bodicherla, Meenal Pathak
Physician burnout is a common problem among US physicians. Burnout has been associated with absenteeism, mood disorders, and medical errors. Over the last several decades, physician burnout has become more prevalent because of increasing workloads, increasing administrative burden, and time spent on electronic medical records, among several other reasons. The rate of suicidal ideation in physicians is almost twice as high as the general population. In addition, studies on mortality related to suicide show that the rates of suicides in physicians are consistently higher than in the general population...
November 2021: Curēus
https://read.qxmd.com/read/34646694/persistent-raynaud-s-phenomenon-following-methylphenidate-hydrochloride-use-during-the-covid-19-pandemic
#6
Christopher Laboe, Emma Batchelder, Deepa Vasireddy
Raynaud's phenomenon (RP) is a medical condition characterized by vasospasm of the digital vessels in the fingers and toes. The prevalence of RP in the general population is estimated at 3-5% and can vary based on climate. It is classified into primary and secondary RP based on causality. RP has been reported in some cases diagnosed with coronavirus disease 2019 (COVID-19) infection. We report the case of a 14-year-old Caucasian female who presented during the pandemic with chief complaints of suicidal ideations and attempted suicide and had a history of attention-deficit hyperactivity disorder (ADHD) and persistent RP after a stimulant trial...
September 2021: Curēus
https://read.qxmd.com/read/34540401/masked-tardive-dyskinesia-in-the-coronavirus-disease-2019-era
#7
Christopher Laboe, Ankit Jain, Hector Cardiel Sam
The universal donning of masks during the coronavirus disease 2019 pandemic led to a decreased ability to read people's facial expressions. In this context, it is prudent to think about how diagnoses can be missed or worsened by the practice of mandatory masking. Here, we report the case of an adolescent white male who presented with new-onset agitation, akathisia, and orofacial dyskinesia in the context of chronic stimulant use for the treatment of attention-deficit hyperactivity disorder and antipsychotic use for oppositional defiant disorder...
August 2021: Curēus
https://read.qxmd.com/read/34388371/philippine-ayta-possess-the-highest-level-of-denisovan-ancestry-in-the-world
#8
JOURNAL ARTICLE
Maximilian Larena, James McKenna, Federico Sanchez-Quinto, Carolina Bernhardsson, Carlo Ebeo, Rebecca Reyes, Ophelia Casel, Jin-Yuan Huang, Kim Pullupul Hagada, Dennis Guilay, Jennelyn Reyes, Fatima Pir Allian, Virgilio Mori, Lahaina Sue Azarcon, Alma Manera, Celito Terando, Lucio Jamero, Gauden Sireg, Renefe Manginsay-Tremedal, Maria Shiela Labos, Richard Dian Vilar, Acram Latiph, Rodelio Linsahay Saway, Erwin Marte, Pablito Magbanua, Amor Morales, Ismael Java, Rudy Reveche, Becky Barrios, Erlinda Burton, Jesus Christopher Salon, Ma Junaliah Tuazon Kels, Adrian Albano, Rose Beatrix Cruz-Angeles, Edison Molanida, Lena Granehäll, Mário Vicente, Hanna Edlund, Jun-Hun Loo, Jean Trejaut, Simon Y W Ho, Lawrence Reid, Kurt Lambeck, Helena Malmström, Carina Schlebusch, Phillip Endicott, Mattias Jakobsson
Multiple lines of evidence show that modern humans interbred with archaic Denisovans. Here, we report an account of shared demographic history between Australasians and Denisovans distinctively in Island Southeast Asia. Our analyses are based on ∼2.3 million genotypes from 118 ethnic groups of the Philippines, including 25 diverse self-identified Negrito populations, along with high-coverage genomes of Australopapuans and Ayta Magbukon Negritos. We show that Ayta Magbukon possess the highest level of Denisovan ancestry in the world-∼30%-40% greater than that of Australians and Papuans-consistent with an independent admixture event into Negritos from Denisovans...
July 29, 2021: Current Biology: CB
https://read.qxmd.com/read/34333028/multi-axes-lead-with-tetrahedral-electrode-tip-for-cardiac-implantable-devices-creative-concept-for-pacing-and-sensing-technology
#9
REVIEW
Abhishek Bhaskaran, Timothy Liang, Ahmed Niri, Mohammed Ali Azam, Stéphane Massé, John Asta, Karl Magtibay, Patrick F H Lai, Christopher Labos, Andrew C T Ha, Kumaraswamy Nanthakumar
BACKGROUND: We developed a multi-axes lead (MaxLead ) incorporating 4 electrodes arranged at the lead-tip, organized in an equidistant tetrahedron. Here, we studied MaxLead performance in sensing, pacing, and activation wavefront-direction analysis. METHODS: Sixteen explanted animal hearts (from 7 pigs, 7 sheep, and 2 rabbits) were used. Pacing threshold was tested from all axes of MaxLead from right-ventricular (RV) apex before and after simulated dislodgement...
November 2021: Canadian Journal of Cardiology
https://read.qxmd.com/read/34176289/association-of-hiv-infection-and-antiretroviral-therapy-with-arterial-stiffness-a-systematic-review-and-meta-analysis
#10
JOURNAL ARTICLE
Alvin Kuate Defo, Mhd Diaa Chalati, Christopher Labos, Lesley K Fellows, Nancy E Mayo, Stella S Daskalopoulou
[Figure: see text].
August 2021: Hypertension
https://read.qxmd.com/read/33753512/multiple-migrations-to-the-philippines-during-the-last-50-000-years
#11
JOURNAL ARTICLE
Maximilian Larena, Federico Sanchez-Quinto, Per Sjödin, James McKenna, Carlo Ebeo, Rebecca Reyes, Ophelia Casel, Jin-Yuan Huang, Kim Pullupul Hagada, Dennis Guilay, Jennelyn Reyes, Fatima Pir Allian, Virgilio Mori, Lahaina Sue Azarcon, Alma Manera, Celito Terando, Lucio Jamero, Gauden Sireg, Renefe Manginsay-Tremedal, Maria Shiela Labos, Richard Dian Vilar, Acram Latiph, Rodelio Linsahay Saway, Erwin Marte, Pablito Magbanua, Amor Morales, Ismael Java, Rudy Reveche, Becky Barrios, Erlinda Burton, Jesus Christopher Salon, Ma Junaliah Tuazon Kels, Adrian Albano, Rose Beatrix Cruz-Angeles, Edison Molanida, Lena Granehäll, Mário Vicente, Hanna Edlund, Jun-Hun Loo, Jean Trejaut, Simon Y W Ho, Lawrence Reid, Helena Malmström, Carina Schlebusch, Kurt Lambeck, Phillip Endicott, Mattias Jakobsson
Island Southeast Asia has recently produced several surprises regarding human history, but the region's complex demography remains poorly understood. Here, we report ∼2.3 million genotypes from 1,028 individuals representing 115 indigenous Philippine populations and genome-sequence data from two ∼8,000-y-old individuals from Liangdao in the Taiwan Strait. We show that the Philippine islands were populated by at least five waves of human migration: initially by Northern and Southern Negritos (distantly related to Australian and Papuan groups), followed by Manobo, Sama, Papuan, and Cordilleran-related populations...
March 30, 2021: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/33694221/unipolar-electrogram-based-voltage-mapping-with-far-field-cancellation-to-improve-detection-of-abnormal-atrial-substrate-during-atrial-fibrillation
#12
JOURNAL ARTICLE
Don Ragot, Sachin Nayyar, Sophia Z Massin, Andrew C T Ha, Sheldon M Singh, Christopher Labos, Adrian Suszko, Rupin Dalvi, Vijay S Chauhan
INTRODUCTION: An important substrate for AF is fibrotic atrial myopathy. Identifying low-voltage, myopathic regions during AF using traditional bipolar voltage mapping is limited by the directional-dependency of wave propagation. Our objective was to evaluate directionally-independent unipolar voltage mapping, but with far-field cancellation, to identify low-voltage regions during AF. METHODS: In 12 patients undergoing pulmonary vein isolation for AF, high-resolution voltage mapping was performed in the left atrium during sinus rhythm and AF using a roving 20-pole circular catheter...
March 11, 2021: Journal of Cardiovascular Electrophysiology
https://read.qxmd.com/read/32806990/microvolt-qrs-alternans-without-microvolt-t-wave-alternans-in-human-cardiomyopathy-a-novel-risk-marker-of-late-ventricular-arrhythmias
#13
JOURNAL ARTICLE
Adrian Suszko, Sachin Nayyar, Christopher Labos, Kumaraswamy Nanthakumar, Arnold Pinter, Eugene Crystal, Vijay S Chauhan
Background Action potential alternans can induce ventricular tachyarrhythmias and manifest on the surface ECG as T-wave alternans (TWA) and QRS alternans (QRSA). We sought to evaluate microvolt QRSA in cardiomyopathy patients in relation to TWA and ventricular tachyarrhythmia outcomes. Methods and Results Prospectively enrolled cardiomyopathy patients (n=100) with prophylactic defibrillators had 12-lead ECGs recorded during ventricular pacing from 100 to 120 beats/min. QRSA and TWA were quantified in moving 128-beat segments using the spectral method...
September 2020: Journal of the American Heart Association
https://read.qxmd.com/read/32360195/bayesian-clinical-trials-the-art-of-moving-forward-while-looking-back
#14
EDITORIAL
Christopher Labos, George Thanassoulis
No abstract text is available yet for this article.
April 28, 2020: Canadian Journal of Cardiology
https://read.qxmd.com/read/32325106/outcomes-in-young-adults-with-tetralogy-of-fallot-and-pulmonary-annular-preserving-or-transannular-patch-repairs
#15
JOURNAL ARTICLE
Robin A Ducas, Louise Harris, Christopher Labos, Govind Krishna Kumar Nair, Rachel M Wald, Edward J Hickey, Candice K Silversides
BACKGROUND: Early surgical tetralogy of Fallot (ToF) repair involved patching across the pulmonic annulus (TAP), which resulted in severe pulmonic regurgitation. Long-term outcome improvements were anticipated with modifications that preserved the pulmonic annulus (AP). The objective of the present study was to evaluate need for late reintervention in adults with AP repair and those with TAP repair. METHODS: We conducted a retrospective review of adults (born 1981-1996) with childhood intra-cardiac ToF repairs at a tertiary care center...
April 20, 2020: Canadian Journal of Cardiology
https://read.qxmd.com/read/32169929/sex-differences-in-the-efficacy-of-antihypertensive-treatment-in-preventing-cardiovascular-outcomes-and-reducing-blood-pressure-protocol-for-a-systematic-review-and-meta-analysis
#16
JOURNAL ARTICLE
Karina Gasbarrino, Christopher Labos, Victoria Mastropietro, Lindsay Hales, Nadia Khan, Doreen Rabi, Stella S Daskalopoulou
INTRODUCTION: Hypertension is a leading cause of mortality worldwide and its prevalence is expected to rise over the next decade. Sex differences exist in the epidemiology and pathophysiology of hypertension. It is well established that antihypertensive treatment can significantly reduce the risk for stroke and other cardiovascular disease events. However, it remains unclear whether this effect is dependent on sex. In this protocol, we outlined a systematic review and meta-analysis to evaluate the effects of antihypertensive therapy in (1) reducing blood pressure and (2) preventing cardiovascular morbidity and mortality outcomes for each sex separately...
March 12, 2020: BMJ Open
https://read.qxmd.com/read/31599200/mortality-benefit-of-alirocumab-a-bayesian-perspective
#17
JOURNAL ARTICLE
Christopher Labos, James M Brophy, Allan Sniderman, George Thanassoulis
Background The ODYSSEY OUTCOMES (Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome) trial demonstrated that alirocumab reduced major cardiovascular events. However, because of the hierarchical testing strategy used for the multiple outcomes examined, the observed reduction in all-cause mortality was labeled "nominally significant" which has clouded its interpretation. Methods and Results We re-analyzed data from ODYSSEY OUTCOMES using Bayesian methods and generated various prior probabilities by incorporating mortality data from previous similar PCSK9 (proprotein convertase subtilisin-kexin type 9) inhibitor trials...
October 15, 2019: Journal of the American Heart Association
https://read.qxmd.com/read/31403078/systematic-review-and-meta-analysis-of-cardiac-involvement-in-mitochondrial-myopathy
#18
JOURNAL ARTICLE
Asfia Quadir, Carly Sabine Pontifex, Helen Lee Robertson, Christopher Labos, Gerald Pfeffer
Objective: Our goal was to perform a systematic review of the literature to demonstrate the prevalence of cardiac abnormalities identified using cardiac investigations in patients with mitochondrial myopathy (MM). Methods: This systematic review surveys the available evidence for cardiac investigations in MM from a total of 21 studies including 825 participants. Data were stratified by genetic mutation and clinical syndrome. Results: We identified echocardiogram and ECG as the principal screening modalities that identify cardiac structural (29%) and conduction abnormalities (39%) in various MM syndromes...
August 2019: Neurology. Genetics
https://read.qxmd.com/read/30089555/multicenter-study-of-ischemic-ventricular-tachycardia-ablation-with-decrement-evoked-potential-deep-mapping-with-extra-stimulus
#19
JOURNAL ARTICLE
Andreu Porta-Sánchez, Nicholas Jackson, Peter Lukac, Steen Buus Kristiansen, Jan Moller Nielsen, Sigfus Gizurarson, Stéphane Massé, Christopher Labos, Karthik Viswanathan, Benjamin King, Andrew C T Ha, Eugene Downar, Kumaraswamy Nanthakumar
OBJECTIVES: The authors conducted a multicenter study of decrement-evoked potential (DEEP)-based functional ventricular tachycardia (VT) substrate modification to evaluate if such a mechanistic and physiological strategy is feasible and efficient in clinical practice and provides reduction in the VT burden. BACKGROUND: Only a fraction of the myocardium targeted in current VT substrate modification procedures is involved in the initiation and perpetuation of VT. The physiological basis of the DEEP strategy for identification of areas of initiation and maintenance of VT was recently established...
March 2018: JACC. Clinical Electrophysiology
https://read.qxmd.com/read/30054146/long-term-outcomes-among-adults-post-transcatheter-atrial-septal-defect-closure-systematic-review-and-meta-analysis
#20
JOURNAL ARTICLE
Sami Alnasser, Douglas Lee, Peter C Austin, Christopher Labos, Mark Osten, David T Lightfoot, Shelby Kutty, Ashish Shah, Lukas Meier, Lee Benson, Eric Horlick
BACKGROUND: Transcatheter Closure (TC) has become the main stay therapy for many secundum atrial septal defects (ASD) based on short and intermediate term outcome data. Long-term safety and efficacy of this approach among adult patients however, is not well established. METHODS AND RESULTS: A comprehensive search of major electronic databases for studies reporting the long-term (≥5 year) outcomes post TC among adults yielded 114 studies, 9 of which had met the inclusion criteria...
November 1, 2018: International Journal of Cardiology
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