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Christopher Labos

Robin A Ducas, Christopher Labos, David Allen, Mehrdad Golian, Maya Jeyaraman, Justin Lys, Amrinder Mann, Leslie Copstein, Sherri Vokey, Rasheda Rabbani, Ryan Zarychanski, Ahmed M Abou-Setta, Alan H Menkis
BACKGROUND: Delays in reperfusion for patients with myocardial ischemia leads to increased morbidity and mortality. The objective of this review was to identify, evaluate, and critically appraise the evidence on whether pre-hospital electrocardiography (ECG) reduces patient mortality and improves post-ST-segment myocardial infarction patient-oriented outcomes. METHODS: We searched PubMed/MEDLINE, EMBASE, and Cochrane Library (1990-2015) for controlled clinical studies...
December 2016: Canadian Journal of Cardiology
Waseem Hindieh, Louise Pilote, Asim Cheema, Hatim Al-Lawati, Christopher Labos, Line Dufresne, James C Engert, George Thanassoulis
OBJECTIVE: A genetic risk score (GRS) for coronary artery disease has recently been shown to be independent of family history (FHx) in predicting future cardiovascular events. We sought to determine whether the presence of these risk factors, either individually or together, was associated with a higher burden of angiographic coronary artery disease. APPROACH AND RESULTS: We included 763 patients with premature acute coronary syndrome (median age, 50 [46-53] years; 30...
June 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
Christopher Labos, Sara C Martinez, Rui Hao Leo Wang, Petra A Lenzini, Louise Pilote, Peter Bogaty, James M Brophy, James C Engert, Sharon Cresci, George Thanassoulis
BACKGROUND: Limited evidence exists regarding the utility of genetic risk scores (GRS) in predicting recurrent cardiovascular events after acute coronary syndrome (ACS). We sought to determine whether a GRS would predict early recurrent cardiovascular events within 1 year of ACS. METHODS & RESULTS: Participants admitted with acute coronary syndromes from the RISCA, PRAXY, and TRIUMPH cohorts, were genotyped for 30 single nucleotide polymorphisms (SNPs) associated with coronary artery disease (CAD) or myocardial infarction (MI) in prior genome wide association studies...
September 2015: Atherosclerosis
Christopher Labos, James M Brophy, George Thanassoulis
No abstract text is available yet for this article.
September 15, 2015: International Journal of Cardiology
Riccardo Proietti, Christopher Labos, Mark Davis, George Thanassoulis, Pasquale Santangeli, Vincenzo Russo, Luigi Di Biase, Jean-Francois Roux, Atul Verma, Andrea Natale, Vidal Essebag
BACKGROUND: It is unknown whether implantable cardioverter-defibrillator (ICD) discharges actively contribute to a worse prognosis independent of the underlying arrhythmia. There is considerable variability in the reported risk of mortality after appropriate and inappropriate ICD shocks. The aim of our systematic review was to provide a reliable effect size of the association between ICD shock and mortality for both types of therapies. METHODS: On the basis of a systematic literature search, 10 studies were considered eligible for inclusion in the analysis, and data on the hazard ratio (HR) of mortality after ICD shock were extracted from each study...
March 2015: Canadian Journal of Cardiology
Christopher Labos, Vivian Nguyen, Nadia Giannetti, Thao Huynh
BACKGROUND: Hyperbilirubinemia is associated with increased mortality in heart failure (HF) patients. We evaluated the impact of evidence-based medical therapy, in particular beta-blocker on the survival of patients with HF and hyperbilirubinemia. METHODS AND RESULTS: We reviewed the charts of all patients followed at our tertiary care heart failure clinic. Hyperbilirubinemia was defined as total bilirubin >30 ┬Ámol/L (1.5 times the upper limit of our laboratory value)...
2014: Open Cardiovascular Medicine Journal
Christopher Labos, Rui Hao Leo Wang, Louise Pilote, Peter Bogaty, James M Brophy, James C Engert, George Thanassoulis
OBJECTIVE: To examine the association between traditional risk factors (TRF) and a Genetic Risk Score (GRS) with age of first acute coronary syndrome (ACS). Early onset ACS may occur due to a high burden of TRFs or to genetic factors that accelerate atherosclerosis. Whether recently discovered genetic variants for ACS are more prevalent at earlier age of first ACS remains unknown. METHODS: To construct a multilocus GRS, participants were genotyped for 30 single nucleotide polymorphisms (SNP) identified from prior genome-wide association studies...
October 2014: Heart: Official Journal of the British Cardiac Society
Christopher Labos, Kaberi Dasgupta, Hacene Nedjar, Gustavo Turecki, Elham Rahme
BACKGROUND: Patients prescribed antiplatelet treatment to prevent recurrent acute myocardial infarction are often also given a selective serotonin reuptake inhibitor (SSRI) to treat coexisting depression. Use of either treatment may increase the risk of bleeding. We assessed the risk of bleeding among patients taking both medications following acute myocardial infarction. METHODS: We conducted a retrospective cohort study using hospital discharge abstracts, physician billing information, medication reimbursement claims and demographic data from provincial health services administrative databases...
November 8, 2011: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
Christopher Labos, Shadi Akhtari
No abstract text is available yet for this article.
June 2010: Canadian Journal of Cardiology
Christopher Labos, Kaberi Dasgupta
INTRODUCTION: Pancytopenia secondary to hepatitis viral infection is a rare but noted clinical entity. An acute aplastic crisis usually occurs shortly after viral infection, however, viral serologies are usually negative and the pancytopenia is often fatal if left untreated. CASE PRESENTATION: A 66-year-old woman presented to the emergency department with shortness of breath and palpitations. She was found to have pulmonary edema secondary to a newly diagnosed atrial fibrillation and was treated with rate control and anticoagulation...
2008: Journal of Medical Case Reports
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