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https://www.readbyqxmd.com/read/27923207/comparing-the-risks-of-hospitalized-heart-failure-associated-with-glinide-sulfonylurea-and-acarbose-use-in-type-2-diabetes-a-nationwide-study
#1
Yen-Chieh Lee, Chia-Hsuin Chang, Yaa-Hui Dong, Jou-Wei Lin, Li-Chiu Wu, Jing-Shiang Hwang, Lee-Ming Chuang
BACKGROUND: Increasing evidence suggests that certain newer anti-diabetic drugs are associated with an increased risk of hospitalized heart failure (HHF). However, the potential risks associated with the use of sulfonylurea and glinide have not been carefully evaluated. METHODS: A retrospective cohort study using the Taiwan National Health Insurance claims database was conducted to examine the risks of HHF among newly diagnosed type 2 diabetic patients who initiated glinide, sulfonylurea, or acarbose therapy during 2006-2012...
November 10, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27909518/symptoms-in-atrial-fibrillation-a-contemporary-review-and-future-directions
#2
REVIEW
Steven T Heidt Bs, Anna Kratz PhD, Kayvan Najarian PhD, Afton L Hassett PsyD, Hakan Oral Md, Richard Gonzalez PhD, Brahmajee K Nallamothu Md Mph, Daniel Clauw Md, Hamid Ghanbari Md Mph
Atrial fibrillation (AF) is the most prevalent arrhythmia leading to hospital admissions in the United States. The majority of patients with AF report symptoms associated with this condition that can lead to a decrease in health related quality of life (HRQOL) and functional status. Therefore, along with reducing the risk of stroke and mortality, improvements in such symptoms are important therapeutic goals in the management of patients with AF. Our current understanding of how AF and symptoms are linked is hampered by the dominant assessment paradigm, where symptoms thought to be associated with AF are measured at a single point in time (frequently at a clinic visit)...
June 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27902412/the-staff-education-to-reducing-ventilator-associated-pneumonia
#3
Gurdal Yilmaz, Hava Aydin, Mustafa Aydin, Sedat Saylan, Hulya Ulusoy, Iftihar Koksal
Mechanical ventilation (MV) is a life-saving invasive procedure performed in intensive care units (ICUs) where critical patients are given advanced support. The purpose of this study was to assess the effect of personnel training on the incidence of ventilator-associated pneumonia (VAP). The study, performed prospectively in the ICU, was planned in two periods. In both periods, patient's characteristics were recorded on patient data forms. In the second period, ICU physicians and assistant health personnel were given regular theoretical and practical training...
October 17, 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27893055/assessment-of-use-vs-discontinuation-of-oral-anticoagulation-after-pulmonary-vein-isolation-in-patients-with-atrial-fibrillation
#4
Sara Själander, Fredrik Holmqvist, J Gustav Smith, Pyotr G Platonov, Milos Kesek, Peter J Svensson, Carina Blomström-Lundqvist, Fariborz Tabrizi, Jari Tapanainen, Dritan Poci, Anders Jönsson, Anders Själander
Importance: Pulmonary vein isolation (PVI) is a recommended treatment for patients with atrial fibrillation, but it is unclear whether it results in a lower risk of stroke. Objectives: To investigate the proportion of patients discontinuing anticoagulation treatment after PVI in association with the CHA2DS2-VASc (congestive heart failure, hypertension, age ≥75 years [doubled], diabetes, stroke [doubled], vascular disease, age 65-74 years, sex category [female]) score, identify factors predicting stroke after PVI, and explore the risk of cardiovascular events after PVI in patients with and without guideline-recommended anticoagulation treatment...
November 23, 2016: JAMA Cardiology
https://www.readbyqxmd.com/read/27881363/association-between-prediabetes-and-risk-of-cardiovascular-disease-and-all-cause-mortality-systematic-review-and-meta-analysis
#5
Yuli Huang, Xiaoyan Cai, Weiyi Mai, Meijun Li, Yunzhao Hu
OBJECTIVES:  To evaluate associations between different definitions of prediabetes and the risk of cardiovascular disease and all cause mortality. DESIGN:  Meta-analysis of prospective cohort studies. DATA SOURCES:  Electronic databases (PubMed, Embase, and Google Scholar). SELECTION CRITERIA:  Prospective cohort studies from general populations were included for meta-analysis if they reported adjusted relative risks with 95% confidence intervals for associations between the risk of composite cardiovascular disease, coronary heart disease, stroke, all cause mortality, and prediabetes...
November 23, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27876214/beneficial-effects-of-plantago-albicans-on-high-fat-diet-induced-obesity-in-rats
#6
Noura Samout, Amani Ettaya, Hafsia Bouzenna, Sana Ncib, Abdelfattah Elfeki, Najla Hfaiedh
Obesity is a one of the main global public health problems associated with chronic diseases such as coronary heart disease, diabetes and cancer. As a solution to obesity, we suggest Plantago albicans, which is a medicinal plant with several biological effects. This study assesses the possible anti-obesity protective properties of Plantago albicans in high fat diet-fed rats. 28 male Wistar rats were divided into 4 groups; a group which received normal diet (C), the second group was fed HDF diet (HDF), the third group was given normal diet supplemented with Plantago albicans (P...
November 18, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27857093/rheumatoid-arthritis-an-update-for-general-dental-practitioners
#7
S de Souza, R K Bansal, J Galloway
Rheumatoid arthritis (RA) is a common chronic inflammatory autoimmune disorder which significantly impacts patients' lives and can lead to permanent disability. Inflammation in RA not only affects joints; but can affect organs including the heart and lungs. Early diagnosis, initiation of intensive drug therapy, and a multidisciplinary care approach have vastly improved the long-term prognosis for those living with the condition. However, RA patients often present with co-morbidities which add to the complexity of clinical management...
November 18, 2016: British Dental Journal
https://www.readbyqxmd.com/read/27846870/oral-health-and-coronary-heart-disease
#8
Marc J Mathews, Edward H Mathews, George E Mathews
BACKGROUND: It is well documented that there is some correlation between poor oral health in the form of periodontal disease and coronary heart disease (CHD). It is unclear whether this correlation is due to a causal relationship or shared underlying disorder such as inflammation. A suitable integrated model of the CHD pathogenetic pathways relevant to periodontal disease may help to elucidate the association. Such a model is currently not available in literature. METHODS: A previously developed integrated model of CHD was used to investigate potential pathogenetic pathways linking periodontal disease to CHD biomarkers...
November 15, 2016: BMC Oral Health
https://www.readbyqxmd.com/read/27846833/oral-health-related-background-factors-and-dental-service-utilisation-among-sudanese-children-with-and-without-a-congenital-heart-defects
#9
H M Ali, M Mustafa, E F Nasir, S A Lie, S Hasabalrasol, O H Elshazali, R W Ali, M S Skeie
BACKGROUND: Sudanese children with congenital heart defects (CHDs) were found to have poorer oral health than those without CHDs. The aims of this study were to: describe the patterns of oral-health-related background factors in children with and without CHD and explore any differences, and to evaluate the effects of background factors on caries and gingivitis prevalence and dental services utilisation. METHODS: In this analytical cross-sectional study, caregivers of children aged 3-12 years with (CHD cases n = 111) and without CHDs (Controls n = 182), underwent face-to-face interviews using a structured questionnaire...
November 15, 2016: BMC Oral Health
https://www.readbyqxmd.com/read/27833985/common-and-unusual-dental-development-abnormalities-in-a-patient-with-bicuspid-aortic-valve
#10
Anca Maria Răducanu, Ion Victor Feraru, Ioana Suciu, Elina Teodorescu, Andreea Cristiana Didilescu, Ileana Ionescu, Ecaterina Ionescu
Bicuspid aortic valve (BAV) is the most common congenital abnormality of the heart. In this condition, instead of three cusps, the aortic valve has two cusps. Children with congenital heart diseases are at increased risk of developing oral diseases, such as: higher number of decayed teeth, developmental anomalies, periodontal disease, malocclusion, dental crowding, as well as susceptibility to develop infective endocarditis from bacteremia caused by chronic poor oral health. However, little information is available regarding oral manifestations and their management in patients with congenital heart defects, despite the importance of these diseases...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27820656/insulinlike-growth-factor-binding-protein-1-and-ghrelin-predict-health-outcomes-among-older-adults-chs-cohort
#11
Robert C Kaplan, Garrett Strizich, Chino Aneke-Nash, Clara Dominguez-Islas, Petra Bůžková, Howard Strickler, Thomas Rohan, Michael Pollak, Lewis Kuller, Jorge R Kizer, Anne Cappola, Christopher I Li, Bruce M Psaty, Anne Newman
CONTEXT: Multiple diseases may explain the association of the growth hormone / insulinlike growth factor-I (GH/IGF-I) axis with longevity. OBJECTIVE: To relate circulating GH/IGF-I system protein levels with major health events. DESIGN: Cohort study Setting: Four US communities Participants: Adults (n=2268) 65 years and older free of diabetes and cardiovascular disease. MEASUREMENTS: We assessed insulinlike growth factor binding protein-1 (IGFBP-1) and ghrelin in fasting and 2-hour oral glucose tolerance test (OGTT) blood samples, as well as fasting IGF-I and IGFBP-3...
November 7, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27816544/low-health-literacy-flashcards-mobile-video-reinforcement-to-improve-medication-adherence-in-patients-on-oral-diabetes-heart-failure-and-hypertension-medications
#12
Denise L Yeung, Kristin S Alvarez, Marissa E Quinones, Christopher A Clark, George H Oliver, Carlos A Alvarez, Adeola O Jaiyeola
OBJECTIVE: To design and investigate a pharmacist-run intervention using low health literacy flashcards and a smartphone-activated quick response (QR) barcoded educational flashcard video to increase medication adherence and disease state understanding. DESIGN: Prospective, matched, quasi-experimental design. SETTING: County health system in Dallas, Texas. PARTICIPANTS: Sixty-eight primary care patients prescribed targeted heart failure, hypertension, and diabetes medications INTERVENTION: Low health literacy medication and disease specific flashcards, which were also available as QR-coded online videos, were designed for the intervention patients...
November 2, 2016: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/27799843/evaluating-the-benefits-of-home-based-management-of-atrial-fibrillation-current-perspectives
#13
REVIEW
Azfar B Sheikh, Jamie R Felzer, Abdullah Bin Munir, Daniel P Morin, Carl J Lavie
Atrial fibrillation (AF) is the most common arrhythmia worldwide, leading to an extensive public health and economic burden. The increasing incidence and prevalence of AF is due to the advancing age of the population, structural heart disease, hypertension, diabetes, and thyroid disease. The majority of costs associated with AF have been attributed to the cost of hospitalization. In order to minimize costs and decrease hospitalizations, counseling on modifiable risk factors contributing to AF has been strongly emphasized...
2016: Pragmatic and Observational Research
https://www.readbyqxmd.com/read/27798047/common-diseases-as-determinants-of-menopausal-age
#14
Jingmei Li, Mikael Eriksson, Kamila Czene, Per Hall, Kenny A Rodriguez-Wallberg
STUDY QUESTION: Can the diagnosis of common diseases before menopause influence age at natural menopause (ANM) onset? SUMMARY ANSWER: Polycystic ovary syndrome (PCOS) and depression were observed to delay menopause. WHAT IS KNOWN ALREADY: It has been observed that women who undergo early menopause experience a higher burden of health problems related to metabolic syndromes, heart disease and depression, but whether ANM can be influenced by common adult diseases has not been studied extensively...
October 18, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27797446/cross-sectional-association-of-endogenous-steroid-hormone-sex-hormone-binding-globulin-and-precursor-steroid-levels-with-hemostatic-factor-levels-in-postmenopausal-women
#15
Laura B Harrington, Brett T Marck, Kerri L Wiggins, Barbara McKnight, Susan R Heckbert, Nancy F Woods, Andrea Z LaCroix, Marc Blondon, Bruce M Psaty, Frits R Rosendaal, Alvin M Matsumoto, Nicholas L Smith
BACKGROUND: Oral use of exogenous estrogen/progestin alters hemostatic factor levels. The influence of endogenous hormones on these levels is incompletely characterized. OBJECTIVES: Our study aimed to test whether, among postmenopausal women, high levels of estradiol (E2), estrone (E1), testosterone (T), dehydroepiandrosterone-sulfate (DHEAS), DHEA, and androstenedione, and low levels of sex hormone-binding globulin (SHBG), are positively associated with measures of thrombin generation (TG), normalized activated protein C sensitivity ratio (nAPCsr), and factor VII activity (FVIIc), and negatively associated with antithrombin activity (ATc) and total protein S antigen (PSAg)...
October 31, 2016: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/27792244/breastfeeding-for-procedural-pain-in-infants-beyond-the-neonatal-period
#16
REVIEW
Denise Harrison, Jessica Reszel, Mariana Bueno, Margaret Sampson, Vibhuti S Shah, Anna Taddio, Catherine Larocque, Lucy Turner
BACKGROUND: Randomised controlled trials (RCTs) show that breastfeeding newborn infants during painful procedures reduces pain. Mechanisms are considered to be multifactorial and include sucking, skin-to-skin contact, warmth, rocking, sound and smell of the mother, and possibly endogenous opiates present in the breast milk. OBJECTIVES: To determine the effect of breastfeeding on procedural pain in infants beyond the neonatal period (first 28 days of life) up to one year of age compared to no intervention, placebo, parental holding, skin-to-skin contact, expressed breast milk, formula milk, bottle feeding, sweet-tasting solutions (e...
October 28, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27792213/insulin-treatment-may-not-be-associated-with-worse-prognosis-in-acute-heart-failure-diabetic-patients
#17
Filipe M Cunha, Pedro Marques, Joana Pereira, Maria J Pinto, Pedro Rodrigues, Helena Moreira, Patrícia Lourenço, Paulo Bettencourt
BACKGROUND: Diabetic patients with heart failure (HF) treated with insulin appear to have a worse prognosis compared to oral anti-diabetic (OAD) agents. Whether insulin is a risk factor or a marker of disease severity is unknown. We studied the prognostic impact of insulin treatment in an acute HF diabetic population. METHODS: From a prospectively recruited population of hospital-admitted acute HF patients we retrospectively selected a convenience sample. Pair-matched analysis: each insulin-treated patient was matched with a diabetic patient with similar glycated haemoglobin (HbA1c±0...
October 28, 2016: Minerva Endocrinologica
https://www.readbyqxmd.com/read/27773799/adverse-effects-of-croton-urucurana-b-exposure-during-rat-pregnancy
#18
Rafaianne Queiroz Moraes-Souza, Thaigra Sousa Soares, Nágilla Orleanne Lima Carmo, Débora Cristina Damasceno, Kleber Eduardo Campos, Gustavo Tadeu Volpato
ETHNOPHARMACOLOGICAL RELEVANCE: Several women often use plant extracts during pregnancy without any concern about its possible toxic effects. The plant effects have been experimentally confirmed in animals and humans, while others require additional investigations. AIM OF STUDY: To evaluated the effect of aqueous extract of Croton urucurana latex on the maternal-fetal repercussions in rats. METHODS: Pregnant rats were randomly distributed into four experimental groups: Control=treated with water (vehicle); Treated 200=treated with a dose 200mg/kg; Treated 400= dose 400mg/kg and; and Treated 800= dose 800mg/kg...
October 20, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27761946/profile-of-diabetes-in-men-aged-79-97-years-the-western-australian-health-in-men-study
#19
M Henze, H Alfonso, L Flicker, J George, S A P Chubb, G J Hankey, O P Almeida, J Golledge, P E Norman, B B Yeap
AIMS: To investigate behavioural, physical and biochemical characteristics associated with diabetes in the oldest age group of elderly men. METHODS: We conducted a cross-sectional analysis of community-dwelling men aged 79-97 years from Perth, Western Australia. Lifestyle behaviours, self-rated health, physical function, and fasting glucose and HbA1c levels were assessed. RESULTS: Of 1426 men, 315 had diabetes (22%). Men with diabetes were of similar age to men without (84...
October 20, 2016: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/27753839/sy-06-3-role-of-surgical-treatment-of-morbid-obesity
#20
Wei-Jei Lee
Obesity is a pan-endemic health problem in both developed and developing countries, in both western and eastern countries. It increases risk for many common diseases, including type 2 diabetes, dyslipidemia, hypertension, obstructive sleep apnea, heart disease, stroke, asthma, osteoarthritis, cancers and depression etc.. Although the incidence of obesity in Asia is relatively low, Asian patients tend to have similar incidence of obesity related metabolic syndrome at lower BMI level comparing to Caucasians because of central obesity...
September 2016: Journal of Hypertension
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