keyword
https://read.qxmd.com/read/35456174/subthreshold-exudative-choroidal-neovascularization-cnv-presentation-of-this-uncommon-subtype-and-other-cnvs-in-age-related-macular-degeneration-amd
#21
REVIEW
Vivian Paraskevi Douglas, Itika Garg, Konstantinos A A Douglas, John B Miller
Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss in people over the age of 50 worldwide. Exudative or neovascular AMD is a more severe subset of AMD which is characterized by the presence of choroidal neovascularization (CNV). Recent advancements in multimodal ophthalmic imaging, including optical coherence tomography (OCT) and OCT-angiography (OCT-A), have facilitated the detection and characterization of previously undetectable neovascular lesions and have enabled a more refined classification of CNV in exudative as well as nonexudative AMD patients...
April 7, 2022: Journal of Clinical Medicine
https://read.qxmd.com/read/35408803/transcriptional-and-distributional-profiling-of-microglia-in-retinal-angiomatous-proliferation
#22
JOURNAL ARTICLE
Anja Schlecht, Julian Wolf, Stefaniya Boneva, Gabriele Prinz, Barbara M Braunger, Peter Wieghofer, Hansjürgen Agostini, Günther Schlunck, Clemens Lange
Macular neovascularization type 3, formerly known as retinal angiomatous proliferation (RAP), is a hallmark of age-related macular degeneration and is associated with an accumulation of myeloid cells, such as microglia (MG) and infiltrating blood-derived macrophages (MAC). However, the contribution of MG and MAC to the myeloid cell pool at RAP sites and their exact functions remain unknown. In this study, we combined a microglia-specific reporter mouse line with a mouse model for RAP to identify the contribution of MG and MAC to myeloid cell accumulation at RAP and determined the transcriptional profile of MG using RNA sequencing...
March 22, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/35140257/classifying-neovascular-age-related-macular-degeneration-with-a-deep-convolutional-neural-network-based-on-optical-coherence-tomography-images
#23
COMPARATIVE STUDY
Jinyoung Han, Seong Choi, Ji In Park, Joon Seo Hwang, Jeong Mo Han, Hak Jun Lee, Junseo Ko, Jeewoo Yoon, Daniel Duck-Jin Hwang
Neovascular age-related macular degeneration (nAMD) is among the main causes of visual impairment worldwide. We built a deep learning model to distinguish the subtypes of nAMD using spectral domain optical coherence tomography (SD-OCT) images. Data from SD-OCT images of nAMD (polypoidal choroidal vasculopathy, retinal angiomatous proliferation, and typical nAMD) and normal healthy patients were analyzed using a convolutional neural network (CNN). The model was trained and validated based on 4749 SD-OCT images from 347 patients and 50 healthy controls...
February 9, 2022: Scientific Reports
https://read.qxmd.com/read/35101110/vitrectomy-subretinal-tissue-plasminogen-activator-and-intravitreal-gas-for-submacular-haemorrhage-secondary-to-exudative-age-related-macular-degeneration-tiger-study-protocol-for-a-phase-3-pan-european-two-group-non-commercial-active-control-observer-masked
#24
JOURNAL ARTICLE
Timothy L Jackson, Catey Bunce, Riti Desai, Jost Hillenkamp, Chan Ning Lee, Noemi Lois, Tunde Peto, Barnaby C Reeves, David H Steel, Rhiannon T Edwards, Jan C van Meurs, Hatem Wafa, Yanzhong Wang
BACKGROUND: Neovascular (wet) age-related macular degeneration (AMD) can be associated with large submacular haemorrhage (SMH). The natural history of SMH is very poor, with typically marked and permanent loss of central vision in the affected eye. Practice surveys indicate varied management approaches including observation, intravitreal anti-vascular endothelial growth factor therapy, intravitreal gas to pneumatically displace SMH, intravitreal alteplase (tissue plasminogen activator, TPA) to dissolve the clot, subretinal TPA via vitrectomy, and varying combinations thereof...
January 31, 2022: Trials
https://read.qxmd.com/read/35034215/subfoveal-choroidal-thickness-after-brolucizumab-therapy-for-neovascular-age-related-macular-degeneration-a-short-term-multicenter-study
#25
MULTICENTER STUDY
Tamaki Tamashiro, Koji Tanaka, Kanako Itagaki, Makiko Nakayama, Ichiro Maruko, Sorako Wakugawa, Nobuhiro Terao, Hajime Onoe, Yu Wakatsuki, Masashi Ogasawara, Yukinori Sugano, Akiko Yamamoto, Keiko Kataoka, Takahiko Izumi, Moeko Kawai, Ryusaburo Mori, Tetsuju Sekiryu, Annabelle A Okada, Tomohiro Iida, Hideki Koizumi
BACKGROUND/PURPOSE: Observation of choroidal thickness after anti-vascular endothelial growth factor (VEGF) therapy may be important for the ideal management of neovascular age-related macular degeneration (AMD). This study investigated changes in subfoveal choroidal thickness (SCT) during loading doses of intravitreal injections of brolucizumab in eyes with neovascular AMD. METHODS: This study included 73 eyes of 72 patients with neovascular AMD at five university hospitals in Japan...
June 2022: Graefe's Archive for Clinical and Experimental Ophthalmology
https://read.qxmd.com/read/34905560/long-term-characteristics-of-exudative-age-related-macular-degeneration-in-japanese-patients
#26
JOURNAL ARTICLE
Masaaki Saito, Tomohiro Iida, Kuniharu Saito, Mariko Kano, Kanako Itagaki, Ichiro Maruko, Tetsuju Sekiryu
PURPOSE: The present study aimed to evaluate the clinical characteristics of exudative age-related macular degeneration (AMD) in Japanese patients over a 10-year period and to compare the past our report. METHODS: We retrospectively reviewed 1,600 treatment-naïve patients (1,777 eyes) with exudative AMD. The 10 years were divided into 2-year phases I to V. RESULTS: Of the 1,600 patients, 720 (45.0%), 733 (45.8%), 98 (6.1%), and 49 (3.1%) were diagnosed with typical AMD, polypoidal choroidal vasculopathy (PCV), retinal angiomatous proliferation, and combined subtypes, respectively...
2021: PloS One
https://read.qxmd.com/read/34817809/the-influence-of-covid-19-on-the-stability-of-patients-with-neovascular-age-related-macular-degeneration-with-different-treatment-regimens
#27
JOURNAL ARTICLE
Bo Jiang, Lin Gao, Su Dong, Qingxue Hou, Minghao Sun, Jingjie Zhang, Haotian Yu, Zhongyu Zhang, Dawei Sun
INTRODUCTION: To explore the impact of coronavirus disease 2019 (COVID-19) on the stability of patients with neovascular age-related macular degeneration (nAMD) receiving the treat and extend (T&E) or the pro re nata (PRN) treatment regimen and to identify indicators that may predict the disease stability of nAMD. METHODS: This is a retrospective study of patients with nAMD treated at the Second Affiliated Hospital of Harbin Medical University whose treatment schedule was interrupted at least once between 1 February and 31 May 2020...
April 2022: Advances in Therapy
https://read.qxmd.com/read/34695835/development-of-macular-atrophy-in-patients-with-wet-age-related-macular-degeneration-receiving-anti-vegf-treatment
#28
REVIEW
Alexander Foss, Tryfon Rotsos, Theo Empeslidis, Victor Chong
Age-related macular degeneration (AMD) is a leading cause of blindness. Late AMD can be classified into exudative (commonly known as wet AMD [wAMD]) or dry AMD, both of which may progress to macular atrophy (MA). MA causes irreversible vision loss and currently has no approved pharmacological treatment. The standard of care for wAMD is treatment with anti-vascular endothelial growth factors (VEGFs). However, recent evidence suggests that anti-VEGF treatment may play a role in the development of MA. Therefore, it is important to identify risk factors for the development of MA in patients with wAMD...
2022: Ophthalmologica. Journal International D'ophtalmologie
https://read.qxmd.com/read/34512255/clinical-pathological-features-and-current-animal-models-of-type-3-macular-neovascularization
#29
REVIEW
Wei Qiang, Ran Wei, Yongjiang Chen, Danian Chen
Type 3 macular neovascularization (MNV3), or retinal angiomatous proliferation (RAP), is a distinct type of neovascular age-related macular degeneration (AMD), which is a leading cause of vision loss in older persons. During the past decade, systematic investigation into the clinical, multimodal imaging, and histopathological features and therapeutic outcomes has provided important new insight into this disease. These studies favor the retinal origin of MNV3 and suggest the involvement of retinal hypoxia, inflammation, von Hippel-Lindau (VHL)-hypoxia-inducible factor (HIF)-vascular endothelial growth factor (VEGF) pathway, and multiple cell types in the development and progression of MNV3...
2021: Frontiers in Neuroscience
https://read.qxmd.com/read/34436646/the-rap-study-report-4-morphological-and-topographical-characteristics-of-multifocal-macular-neovascularization-type-3
#30
JOURNAL ARTICLE
Bilal Haj Najeeb, Gabor G Deak, Stefan Sacu, Ursula Schmidt-Erfurth, Bianca S Gerendas
PURPOSE: To report on the morphological characteristics and regional distribution of multifocal macular neovascularization type 3 (mMNV3). METHODS: Twenty-two consecutive eyes of 21 patients with mMNV3 were included using multimodal imaging. The count and stage of lesions of all MNV types and the existence of exudate and hemorrhage were determined. Also, we addressed the regional distribution of MNV3 lesions between the superior-inferior and the nasal-temporal halves of the macula, and the range of the distance of the lesions from the central fovea...
January 2022: Graefe's Archive for Clinical and Experimental Ophthalmology
https://read.qxmd.com/read/34314466/drusen-and-pigment-abnormality-predict-the-development-of-neovascular-age-related-macular-degeneration-in-japanese-patients
#31
JOURNAL ARTICLE
Shoji Notomi, Satomi Shiose, Keijiro Ishikawa, Yosuke Fukuda, Kumiko Kano, Kenichiro Mori, Iori Wada, Yoshihiro Kaizu, Hidetaka Matsumoto, Masato Akiyama, Koh-Hei Sonoda
Drusen are known to be the important hallmark to predict the development of age-related macular degeneration (AMD). The prevalence of drusen is lower in Asians compared with Caucasians so that the role of signs constituting early AMD is not well established in Asian populations as in Western countries. In this study, we retrospectively investigated clinical characteristics and 5-year incidence of neovascular AMD (nAMD) in the fellow eye of unilateral nAMD patients. Of 296 consecutive unilateral nAMD patients who had been followed up more than 5 years, 170 typical AMD, 119 polypoidal choroidal vasculopathy, and 7 retinal angiomatous proliferation were included...
2021: PloS One
https://read.qxmd.com/read/34101693/geographic-atrophy-incidence-and-progression-after-intravitreal-injections-of-anti-vascular-endothelial-growth-factor-agents-for-age-related-macular-degeneration-a-meta-analysis
#32
JOURNAL ARTICLE
Arshia Eshtiaghi, Mariam Issa, Marko M Popovic, Rajeev H Muni, Peter J Kertes
PURPOSE: Geographic atrophy (GA) is a complication of advanced neovascular age-related macular degeneration that can lead to permanent vision loss. We sought to estimate the incidence and progression of GA after intravitreal injections of antivascular endothelial growth factor agents in eyes with neovascular age-related macular degeneration. METHODS: Ovid MEDLINE, EMBASE, and Cochrane CENTRAL were searched from inception to May 2020. Included studies reported on the progression or development of GA in eyes with neovascular age-related macular degeneration after antivascular endothelial growth factor therapy...
December 1, 2021: Retina
https://read.qxmd.com/read/34055256/clinical-and-multimodal-imaging-features-of-subretinal-drusenoid-deposits
#33
JOURNAL ARTICLE
Devesh Kumawat, Srikanta K Padhy, Vinod Kumar
PURPOSE: To describe the multimodal imaging (MMI) features of subretinal drusenoid deposits (SDD) in Indian population. METHODS: Patients diagnosed to have SDD from January 2016 to December 2018 at our tertiary care center were recruited. The diagnosis of SDD was made on the basis of MMI consisting of a combination of color fundus photography (CFP), optical coherence tomography (OCT), red-free (RF) imaging, blue autofluorescence (BAF), and near-infra red reflectance (NIR) imaging...
April 2021: Journal of Ophthalmic & Vision Research
https://read.qxmd.com/read/33927240/distinguishing-retinal-angiomatous-proliferation-from-polypoidal-choroidal-vasculopathy-with-a-deep-neural-network-based-on-optical-coherence-tomography
#34
JOURNAL ARTICLE
Daniel Duck-Jin Hwang, Seong Choi, Junseo Ko, Jeewoo Yoon, Ji In Park, Joon Seo Hwang, Jeong Mo Han, Hak Jun Lee, Joonhong Sohn, Kyu Hyung Park, Jinyoung Han
This cross-sectional study aimed to build a deep learning model for detecting neovascular age-related macular degeneration (AMD) and to distinguish retinal angiomatous proliferation (RAP) from polypoidal choroidal vasculopathy (PCV) using a convolutional neural network (CNN). Patients from a single tertiary center were enrolled from January 2014 to January 2020. Spectral-domain optical coherence tomography (SD-OCT) images of patients with RAP or PCV and a control group were analyzed with a deep CNN. Sensitivity, specificity, accuracy, and area under the receiver operating characteristic curve (AUROC) were used to evaluate the model's ability to distinguish RAP from PCV...
April 29, 2021: Scientific Reports
https://read.qxmd.com/read/33920794/drusenoid-pigment-epithelial-detachment-genetic-and-clinical-characteristics
#35
JOURNAL ARTICLE
Taiyo Shijo, Yoichi Sakurada, Koji Tanaka, Akiko Miki, Seigo Yoneyama, Yumiko Machida, Aya Chubachi, Yu Wakatsuki, Atsushi Sugiyama, Hajime Onoe, Wataru Kikushima, Ryusaburo Mori, Kenji Kashiwagi
Few studies report drusenoid pigment epithelial detachment (DPED) in Asians. In this multicenter study, we report the clinical and genetic characteristics of 76 patients with DPED, and, for comparison, 861 patients with exudative age-related macular degeneration (AMD) were included. On the initial presentation, the mean best-corrected visual acuity was 0.087 ± 0.17 (logMAR unit), and mean DPED height and width were 210 ± 132 and 1633 ± 1114 µm, respectively. Fifty-one (67%) patients showed macular neovascularization in the contralateral eye...
April 15, 2021: International Journal of Molecular Sciences
https://read.qxmd.com/read/33821577/the-rap-study-report-3-discoloration-of-the-macular-region-in-patients-with-macular-neovascularization-type-3
#36
JOURNAL ARTICLE
Bilal Haj Najeeb, Gabor G Deak, Ursula Schmidt-Erfurth, Bianca S Gerendas
BACKGROUND/AIMS: To explore whether the existence and pattern of distribution of macular haemorrhage or exudate can be valuable diagnostic markers for macular neovascularization type 3 (MNV3) in patients with neovascular age-related macular degeneration. METHODS: Eighty-three eyes of 83 consecutive treatment naïve patients with stage 3 MNV3 were enrolled. The diagnosis was based on fluorescein angiography (FA) and optical coherence tomography (OCT). Subretinal and intraretinal haemorrhage and dense exudates were evaluated on colour fundus photography...
April 5, 2021: Acta Ophthalmologica
https://read.qxmd.com/read/33744984/assessing-the-long-term-evolution-of-type-3-neovascularization-in-age-related-macular-degeneration-using-optical-coherence-tomography-angiography
#37
JOURNAL ARTICLE
Han Joo Cho, Soo Hyun Lim, Jaemin Kim, Jihyun Lee, Dong Won Lee, Jong Woo Kim
PURPOSE: To analyze the evolution of type 3 neovascularization in eyes with age-related macular degeneration during anti-vascular endothelial growth factor (VEGF) treatment using optical coherence tomography angiography (OCTA) analysis. METHODS: Forty-one treatment-naïve eyes (37 patients) with type 3 neovascularization were retrospectively included in the study. The growth and morphological changes in the type 3 lesions, which were recorded using OCTA, were compared across time...
March 21, 2021: Graefe's Archive for Clinical and Experimental Ophthalmology
https://read.qxmd.com/read/33613250/efficacy-of-psychiatric-treatment-to-treat-a-specific-phobia-of-intravitreal-injections-in-a-patient-with-neovascular-age-related-macular-degeneration
#38
Atsuta Ozaki, Hisashi Matsubara, Masahiko Sugimoto, Manami Kuze, Mineo Kondo, Takashi Shiroyama
Intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF) is essential for the treatment of macular diseases such as wet age-related macular degeneration and macular edema. Although continued treatment is needed to maintain good vision, some patients cannot continue such injections for various reasons, including specific phobias. Here, we report a case of a patient with a specific phobia of intravitreal injections who could resume treatment after undergoing combined drug and cognitive-behavioral therapy (CBT)...
January 2021: Case Reports in Ophthalmology
https://read.qxmd.com/read/33426922/macular-fibrosis-in-coats-disease-demonstrated-by-optical-coherence-tomography-angiography-new-data-toward-pathophysiology
#39
JOURNAL ARTICLE
Katarzyna Chwiejczak, Susmito Biswas, Emmanouil Tsamis, Irene Siso-Fuertes, Shakti Kasbia, Paulo E Stanga
PURPOSE: To analyze if Segmented Swept-Source Optical Coherence Tomography Angiography (SS OCT-A) can provide additional information on morphology and pathophysiology of macular fibrosis in Coats' patients. METHODS: A consecutive case series of three male patients (5, 7 and 15 years old), with Coats' disease-related macular fibrosis (stage 2b-2 patients, 3b-1 patient). SS OCT-A 3×3 mm macular scans of affected eyes were performed. RESULTS: In all three cases the inner portion of macular fibrosis displayed a dense network of vessels, continuing into deeper layers...
January 9, 2021: European Journal of Ophthalmology
https://read.qxmd.com/read/33404679/difference-in-treatment-burden-of-neovascular-age-related-macular-degeneration-among-different-types-of-neovascularization
#40
JOURNAL ARTICLE
Ji Hyun Lee, Jae Hui Kim, Jong Woo Kim, Chul Gu Kim, Dong Won Lee
PURPOSE: To evaluate the difference in the treatment burden among different types of neovascular age-related macular degeneration (AMD). METHODS: This retrospective, observational study included 431 patients who were diagnosed with neovascular AMD. Patients were divided into three groups: type 1 or 2 neovascularization group (n = 167), type 3 neovascularization group (n = 50), and polypoidal choroidal vasculopathy (PCV) group (n = 214). The number of hospital visits per year and the number of anti-vascular endothelial growth factor (VEGF) injections per year were compared among these groups...
January 6, 2021: Graefe's Archive for Clinical and Experimental Ophthalmology
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