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retinal angiomatous proliferation

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https://www.readbyqxmd.com/read/29768269/long-term-results-of-combination-treatment-with-single-dose-ranibizumab-plus-photodynamic-therapy-for-retinal-angiomatous-proliferation
#1
Panagiotis Malamos, Ioannis Tservakis, Menelaos Kanakis, Chrysoula Koutsiouki, Evita Kiskira, Georgios Mylonas, John Lakoumentas, Ilias Georgalas
PURPOSE: To present functional and anatomic outcomes of combination therapy with ranibizumab and photodynamic therapy (PDT) in a series of retinal angiomatous proliferation (RAP) cases. METHODS: A total of 17 eyes of 17 patients with RAP were included. Thirteen eyes were treatment naïve and 4 were already on ranibizumab monotherapy. Combined treatment with single-dose ranibizumab and PDT was performed on all treatment-naïve cases. Follow-up was performed every month for 6-38 months, using optical coherence tomography and indocyanine green angiography when necessary...
May 16, 2018: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/29768266/subfoveal-choroidal-thickness-in-eyes-with-neovascular-age-related-macular-degeneration-treated-with-anti-vascular-endothelial-growth-factor-agents
#2
Tereza Cristina Moreira Kanadani, Carlos Eduardo Veloso, Márcio B Nehemy
PURPOSE: We aimed to assess the subfoveal choroidal thickness (SFChT) and the effect of treatment with anti-vascular endothelial growth factor (anti-VEGF) agents on the SFChT in age-related macular degeneration (AMD) subtypes. METHODS: We enrolled 128 eyes of 107 patients with neovascular AMD (60 women; 47 men; mean age, 73.6 ± 8.9 years), and prospectively evaluated the best-corrected visual acuity (BCVA) and SFChT at baseline and at 3, 6, and 12 months after treatment with anti-VEGF agents...
May 16, 2018: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/29755818/retinal-angiomatous-proliferation-multimodal-imaging-characteristics-and-follow-up-with-eye-tracked-spectral-domain-optical-coherence-tomography-of-precursor-lesions
#3
Zafer Öztaş, Jale Menteş
Objectives: To present the multimodal imaging characteristics of precursor retinal angiomatous proliferation (RAP) lesions and follow-up results with eye-tracked spectral-domain optical coherence tomography (SD-OCT). Materials and Methods: Six eyes of 6 patients aged 77.5±5.9 years diagnosed with precursor RAP lesion were included in this prospective observational case series. Best corrected visual acuity (BCVA) measurement and complete ophthalmologic examination were performed for all subjects, as well as fundus photography (FP), fundus autofluorescence (FAF), SD-OCT, fluorescein angiography (FA), indocyanine green angiography (ICGA), optical coherence tomography angiography (OCTA), and their long-term follow-up results are presented...
April 2018: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/29721942/the-role-of-hypoxia-hypoxia-inducible-factor-hif-and-vegf-in-retinal-angiomatous-proliferation
#4
Maya Barben, Marijana Samardzija, Christian Grimm
In industrialized countries, age-related macular degeneration (AMD) is the leading cause of blindness in elderly people. Hallmarks of the non-neovascular (dry) form of AMD are the formation of drusen and geographic atrophy, whereas the exudative (wet) form of the disease is characterized by invading blood vessels. In retinal angiomatous proliferation (RAP), a special form of wet AMD, intraretinal vessels grow from the deep plexus into the subretinal space. Little is known about the mechanisms leading to intraretinal neovascularization, but age-related changes such as reduction of choroidal blood flow, accumulation of drusen, and thickening of the Bruch's membrane may lead to reduced oxygen availability in photoreceptors...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29594794/case-series-of-coexistence-of-polypoidal-choroidal-vasculopathy-with-other-rare-fundus-diseases
#5
Chengguo Zuo, Xiongze Zhang, Miaoling Li, Yuting Peng, Lan Mi, Bing Liu, Feng Wen
PURPOSE: To record the coexistence of polypoidal choroidal vasculopathy (PCV) with other rare fundus diseases in a Chinese population. METHOD: In this retrospective hospital-based study, a chart review of 861 patients with newly diagnosed PCV was performed. The clinical features of rare fundus comorbidities of PCV were recorded. RESULTS: Five eyes of 5 patients aged 63.4 ± 11.22 years (0.58%) had PCV coexisting with other fundus diseases in the same eye...
March 28, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29575941/treatment-outcomes-of-conventional-or-high-dose-ranibizumab-for-vascularized-pigment-epithelial-detachment-based-on-lesion-subtypes
#6
Clement K Chan, David Sarraf, Prema Abraham
INTRODUCTION: A post hoc study was conducted to compare visual and anatomic outcomes of vascularized serous pigment epithelial detachment (Group 1) with fibrovascular pigment epithelial detachment (Group 2) due to age-related macular degeneration treated with either 0.5 or 2.0 mg ranibizumab injections. METHODS: A prospective, randomized trial was performed with the following regimens for 12 months: (1) 0.5 mg monthly, (2) 0.5 mg monthly for 4 months followed by pro re nata injections, (3) 2...
February 1, 2018: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/29370035/macular-atrophy-incidence-in-anti-vascular-endothelial-growth-factor-treated-neovascular-age-related-macular-degeneration-risk-factor-evaluation-for-individualized-treatment-need-of-ranibizumab-or-aflibercept-according-to-an-observe-and-plan-regimen
#7
Irmela Mantel, Ali Dirani, Marta Zola, Parmis Parvin, Sophie De Massougnes, Ciara Bergin
PURPOSE: To investigate factors associated with macular atrophy (MA) incidence in neovascular age-related macular degeneration treated with either ranibizumab or aflibercept in an Observe-and-Plan variable dosing regimen. METHODS: Information was obtained from two identical prospective treatment protocols using ranibizumab or aflibercept in a variable dosing regimen termed "Observe and Plan." Eyes without MA at baseline were included. New atrophy at the final 2-year visit was investigated with univariate and multivariate analysis to identify associated risk factors, focusing on treatment factors...
January 23, 2018: Retina
https://www.readbyqxmd.com/read/29326855/all-types-of-age-related-macular-degeneration-in-one-patient
#8
Zafer Cebeci, Nur Kır
Herein, we describe a neovascular age-related macular degeneration patient with retinal angiomatous proliferation (RAP) and polypoidal choroidal vasculopathy (PCV) coexisting in the same eye at the time of diagnosis. A 55-year-old woman presented with a history of decreased vision in her left eye. Fundoscopy, fluorescein and indocyanine green angiography, and optical coherence tomography imaging revealed RAP and PCV lesions in her left eye at first diagnosis. The patient received intravitreal ranibizumab therapy but developed tachyphylaxis after the first dose despite having three monthly doses...
December 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/29260118/projection-resolved-optical-coherence-tomography-angiography-exhibiting-early-flow-prior-to-clinically-observed-retinal-angiomatous-proliferation
#9
Kavita V Bhavsar, Yali Jia, Jie Wang, Rachel C Patel, Andreas K Lauer, David Huang, Steven T Bailey
Purpose: The purpose of this study is to analyze early retinal angiomatous proliferation (RAP) utilizing a novel imaging modality, Projection-Resolved Optical Coherence Tomography Angiography (PR-OCTA). Observations: Five months prior to the diagnosis of a RAP lesion, cross-sectional PR-OCTA demonstrated flow in the outer retina contiguous with the deep retinal capillary plexus (DCP) and adjacent to a small pigment epithelial detachment. After development of a clinically visible RAP lesion, cross-sectional PR-OCTA demonstrated the RAP lesion connecting DCP and sub-retinal pigment epithelial neovascularization...
December 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29169154/development-of-age-related-macular-degeneration-amd-in-the-fellow-eye-of-patients-with-amd-treated-by-treat-and-extend-intravitreal-therapy-with-aflibercept
#10
Kensuke Mimura, Hidetaka Matsumoto, Masahiro Morimoto, Hideo Akiyama
PURPOSE: To evaluate the development of neovascular age-related macular degeneration (nAMD) in the fellow eye in patients with unilateral nAMD treated by a treat-and-extend (TAE) regimen with intravitreal aflibercept injections. METHODS: We retrospectively studied 104 patients with treatment-naïve unilateral nAMD. We assessed best-corrected visual acuity (BCVA) and exudative changes in the treated eyes and development of nAMD in the fellow eye for 2 years. RESULTS: The subjects included 46 patients with typical AMD (tAMD), 44 with polypoidal choroidal vasculopathy (PCV), and 14 with retinal angiomatous proliferation (RAP)...
2018: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/29130626/age-related-macular-degeneration-using-morphological-predictors-to-modify-current-treatment-protocols
#11
REVIEW
Mohammed Ashraf, Ahmed Souka, Ron A Adelman
To assess predictors of treatment response in neovascular age-related macular degeneration (AMD) in an attempt to develop a patient-centric treatment algorithm. We conducted a systematic search using PubMed, EMBASE and Web of Science for prognostic indicators/predictive factors with the key words: 'age related macular degeneration', 'neovascular AMD', 'choroidal neovascular membrane (CNV)', 'anti-vascular endothelial growth factor (anti-VEGF)', 'aflibercept', 'ranibizumab', 'bevacizumab', 'randomized clinical trials', 'post-hoc', 'prognostic', 'predictive', 'response' 'injection frequency, 'treat and extend (TAE), 'pro re nata (PRN)', 'bi-monthly' and 'quarterly'...
March 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29065425/multimodal-evaluation-of-the-fellow-eye-of-patients-with-retinal-angiomatous-proliferation
#12
Amélia Martins, Cláudia Farinha, Miguel Raimundo, Marta Lopes, Ana Rita Santos, Pedro Melo, Marco Marques, João Pedro Marques, Patrícia Barreto, Maria Luz Cachulo, Catarina Neves, José Cunha-Vaz, Rufino Silva
INTRODUCTION: We conducted a multimodal, cross-sectional evaluation. METHODS: Eyes were divided into 4 study groups: controls, early/intermediate age-related macular degeneration (AMD), fellow eyes of retinal angiomatous proliferation (RAP), and RAP eyes. Patients were evaluated with spectral-domain optical coherence tomography (OCT), enhanced depth imaging-OCT, and OCT angiography (OCTA). OCTA images were processed to generate maps of the vessel density and perfusion density of the superficial and deep retinal layers (SRL and DRL) and the choriocapillaris level (CL)...
2018: Ophthalmic Research
https://www.readbyqxmd.com/read/29023498/incidence-and-risk-factors-of-massive-subretinal-hemorrhage-in-retinal-angiomatous-proliferation
#13
Jae Hyung Lee, Mee Yon Lee, Won Ki Lee
OBJECTIVE: To evaluate the incidence and associated risk factors of massive subretinal hemorrhage (SRH) in patients with retinal angiomatous proliferation (RAP). METHODS: A total of 187 eyes of 135 treatment-naıve patients diagnosed with RAP were evaluated retrospectively. Clinical records including the time between the initial visit, last anti-vascular endothelial growth factor (VEGF) treatment, last stable examination, and the date of massive SRH were reviewed...
2017: PloS One
https://www.readbyqxmd.com/read/29019795/difference-in-treatment-outcomes-according-to-optical-coherence-tomography-based-stages-in-type-3-neovascularization-retinal-angiomatous-proliferation
#14
Jae Hui Kim, Young Suk Chang, Jong Woo Kim, Chul Gu Kim, Dong Won Lee, Soo Yeon Cho
PURPOSE: To compare 12-month treatment outcomes of Type 3 neovascularization among its different stages as classified using an optical coherence tomography-based method. METHODS: This retrospective observational study included 40 patients (40 eyes) who were newly diagnosed with Type 3 neovascularization. The patients were initially administered 3 monthly anti-vascular endothelial growth factor injections. Repeat treatment was performed when recurrence of fluid was noted...
October 10, 2017: Retina
https://www.readbyqxmd.com/read/28971633/anti-vegf-therapy-for-neovascular-amd-and-polypoidal-choroidal-vasculopathy
#15
REVIEW
Gemmy Chui Ming Cheung, Timothy Y Y Lai, Fumi Gomi, Paisan Ruamviboonsuk, Adrian Koh, Won Ki Lee
Anti-vascular endothelial growth factor (anti-VEGF) therapy has revolutionized the treatment of neovascular age-related macular degeneration (AMD). This review will summarize the current evidence of anti-VEGF therapy in neovascular AMD, including subtypes of retinal angiomatous proliferation and polypoidal choroidal vasculopathy (PCV). Importantly, 2 large multicenter randomized clinical trials evaluating the safety and efficacy of anti-VEGF monotherapy and combination with photodynamic therapy (PDT) have recently reported initial first-year outcomes...
November 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28905541/the-role-of-new-imaging-methods-in-managing-age-related-macular-degeneration
#16
REVIEW
Stephen James Talks, Akhunzada Muhammad Aftab, Imran Ashfaq, Taha Soomro
The use of imaging for age-related macular degeneration (AMD) depends on how it benefits clinical management and on reimbursement. The latter should relate to the former. This review assesses how different forms of AMD can be imaged and what information this provides. For nonneovascular AMD high-resolution optical coherence tomography (OCT), autofluorescence, and near infrared imaging can identify the type of drusen, such as reticular pseudodrusen, which influences prognosis, and the amount of atrophy, for which phase 3 trials are underway...
November 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28810842/erratum-to-short-term-efficacy-of-intravitreal-aflibercept-injections-for-retinal-angiomatous-proliferation
#17
Hung-Da Chou, Wei-Chi Wu, Nan-Kai Wang, Lan-Hsin Chuang, Kuan-Jen Chen, Chi-Chun Lai
No abstract text is available yet for this article.
August 15, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28810047/optical-coherence-tomography-angiography-of-retinal-cavernous-hemangioma
#18
Luisa Pierro, Alessandro Marchese, Marco Gagliardi, Francesco Bandello
Retinal cavernous hemangioma is a rare, benign, retinal tumor characterized by angiomatous proliferation of vessels within the inner retina or the optic disc.1 Here we report a case of retinal cavernous hemangioma on the margin of the optic disc in the right eye of a 61-year-old asymptomatic female. The lesion was studied with multimodal imaging which included structural optical coherence tomography, fluorescein angiography, blue fundus auto-fluorescence, optical coherence tomography angiography (OCTA) (DRI OCT Triton; Topcon, Tokyo, Japan) and visual field examination...
August 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28766278/oct-angiography-demonstrates-retinal-angiomatous-proliferation-and-chorioretinal-anastomosis-of-type-3-neovascularization
#19
Reema Bansal, Varshitha Hemanth, Samyak Mulkutkar, Ramandeep Singh, Vishali Gupta, Mangat R Dogra, Amod Gupta
PURPOSE: To report the OCT angiography findings of type 3 neovascularization. METHODS: Two cases (one each with retinal angiomatous proliferation and chorioretinal anastomosis) are reported, in which the conventional fundus fluorescein angiography and spectral-domain optical coherence tomography findings were inconclusive. RESULTS: OCT angiography demonstrated flow within the abnormal anastomotic network and delineated the extent of the lesion with respect to the retinal layers...
August 1, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28721006/incidence-of-outer-retinal-tubulation-in-eyes-with-choroidal-neovascularization-under-intravitreal-anti-vascular-endothelial-growth-factor-therapy-in-a-japanese-population
#20
Seiji Takagi, Michiko Mandai, Noriko Miyamoto, Akihiro Nishida, Yasuhiko Hirami, Hirofumi Uyama, Midori Yamamoto, Masayo Takahashi, Goji Tomita, Yasuo Kurimoto
PURPOSE: The purpose of this study was to investigate the occurrence of outer retinal tubulation (ORT) among patients with different types of choroidal neovascularization (CNV) over time. MATERIALS AND METHODS: In this retrospective chart review, disease type was classified as typical age-related macular degeneration (t-AMD), polypoidal choroidal vasculopathy (PCV), retinal angiomatous proliferation (RAP), or myopic CNV (mCNV). Spectral domain-optical coherence tomography (SD-OCT) images were evaluated for the appearance of ORT and subretinal fibrosis and fluid...
2017: Clinical Ophthalmology
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